title: Nonregenerative anemia: mechanisms of decreased or ineffective erythropoiesis.
abstract: In veterinary medicine, anemia without an appropriate compensatory hematopoietic response is termed nonregenerative. Nonregenerative anemia is a common clinical entity, occurring as a result of diminished or ineffective erythropoiesis in association with many types of pathology. This article reviews nonregenerative anemia in domestic animals, emphasizing mechanisms of disease, and also covers other conditions associated with nonregenerative anemia in people. Many aspects of nonregenerative anemia in animals are worthy of further investigation, from molecular mechanisms of disease to epidemiologic impacts.
authors.affiliation: Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
authors.forename: C N
authors.initials: CN
authors.lastname: Grimes
authors.affiliation: Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA mfry@utk.edu.
authors.forename: M M
authors.initials: MM
authors.lastname: Fry
mesh_terms: D000740:Anemia / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D004920:Erythropoiesis; D009928:Organ Specificity
keywords: anemia; erythropoiesis; hematology; nonregenerative; reticulocyte; veterinary