title: Predicting infant neurodevelopmental outcomes using the placenta?
abstract: Identifying those infants most at risk for poor neurodevelopmental outcomes is crucial to allow for targeted surveillance or preventative interventions to be instigated from birth. One intriguing possibility is to use the molecular characteristics of the placenta at birth as a 'molecular barometer' of the in utero experience to predict future infant neurodevelopmental outcomes. Here we highlight the recent advances in the field and discuss the possibilities for an integrated approach across the '-omics' categories.
authors.affiliation: Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland; Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland. Electronic address: g.okeeffe@ucc.ie.
authors.forename: Gerard W
authors.initials: GW
authors.lastname: O'Keeffe
authors.affiliation: Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland; Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, Cork, Ireland. Electronic address: l.kenny@ucc.ie.
authors.forename: Louise C
authors.initials: LC
authors.lastname: Kenny
mesh_terms: D001321:Autistic Disorder / Q000209:etiology; D002657:Child Development; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D007236:Infant, Small for Gestational Age; D020738:Leptin / Q000378:metabolism; D008745:Methylation; D010920:Placenta / Q000502:physiology / Q000503:physiopathology*; D011247:Pregnancy
chemical_list: D020738:Leptin
keywords: integrated ‘-omics’; neurodevelopment; placenta; screening