title: Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice.
abstract: Inflammation plays a crucial role in the pathogenesis of obesity. Purple sweet potato color (PSPC) has potential anti-inflammation efficacy. We evaluated the effect of PSPC on kidney injury induced by high fat diet (HFD) and explored the mechanism underlying these effects. The results showed that PSPC (700 mg/kg per day) reduced body weight, ratio of urine albumin to creatinine, inflammatory cell infiltration, and Collagen IV accumulation in mice fed an HFD (60% fat food) for 20 weeks. PSPC significantly reduced the expression level of kidney NLRP3 inflammasome including NLRP3 and ASC and Caspase-1, and resulted in decline of IL-1β. Moreover, PSPC inhibited the activation of I kappa B kinase β (IKKβ) and the nuclear translocation of nuclear factor kappa beta (NF-κB). Additionally, PSPC decreased the expression level of oxidative stress-associated AGE receptor (RAGE) and thioredoxin interacting protein (TXNIP) in the upstream of NLRP3 inflammasome. These data imply that the beneficial effects of PSPC on HFD-induced kidney dysfunction and damage are mediated through NLRP3 signaling pathways, suggesting a potential target for the prevention of obesity.
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: shanp@jsnu.edu.cn.
authors.forename: Qun
authors.initials: Q
authors.lastname: Shan
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: ylzheng@jsnu.edu.cn.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: lu-jun75@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: zhangzifengsuper@jsnu.edu.cn.
authors.forename: Zifeng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: wdm8610@jsnu.edu.cn.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: fshfly@126.com.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Fan
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: hubin@jsnu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: caixiangjun1@163.com.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Cai
authors.affiliation: Kewen College, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: caihao9107@163.cm.
authors.forename: Hao
authors.initials: H
authors.lastname: Cai
authors.affiliation: Kewen College, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: lpl221700@163.com.
authors.forename: Peilong
authors.initials: P
authors.lastname: Liu
authors.affiliation: Kewen College, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, PR China. Electronic address: liufan_001@hotmail.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
mesh_terms: D000419:Albuminuria / Q000188:drug therapy; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D002352:Carrier Proteins / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects*; D058847:Inflammasomes / Q000378:metabolism; D007333:Insulin Resistance; D027723:Ipomoea batatas / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008813:Mice, Inbred ICR; D016328:NF-kappa B / Q000378:metabolism; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013879:Thioredoxins / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D002352:Carrier Proteins; D058847:Inflammasomes; D016328:NF-kappa B; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; C445672:Txnip protein, mouse; D013879:Thioredoxins
keywords: HFD; Kidney damage; NLRP3 inflammasome; Oxidative stress; PSPC