title: fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies.
abstract: Cognitive fluctuations are a core symptom in dementia with Lewy bodies (DLB) and may relate to pathological alterations in distributed brain networks. To test this we analysed resting state fMRI changes in a cohort of fluctuating DLB patients (n = 16) compared with age matched controls (n = 17) with the aim of finding functional connectivity (FC) differences between these two groups and whether these associate with cognitive fluctuations in DLB. Resting state networks (RSNs) were estimated using independent component analysis and FC between the RSN maps and the entirety of the brain was assessed using dual regression. The default mode network (DMN) appeared unaffected in DLB compared to controls but significant cluster differences between DLB and controls were found for the left fronto-parietal, temporal, and sensory-motor networks. Desynchronization of a number of cortical and subcortical areas related to the left fronto-parietal network was associated with the severity and frequency of cognitive fluctuations. Our findings provide empirical evidence for the potential role of attention-executive networks in the aetiology of this core symptom in DLB.
authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Peraza
authors.affiliation: School of Computing Science, Newcastle University, Newcastle upon Tyne NE4 5PL, UK ; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK ; Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
authors.forename: Marcus
authors.initials: M
authors.lastname: Kaiser
authors.affiliation: Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Firbank
authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK ; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Graziadio
authors.affiliation: Department of Neuroscience and Imaging, "G. d'Annunzio" University, Chieti, Italy ; Aging Research Centre, Ce. S.I., "G. d'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonanni
authors.affiliation: Department of Neuroscience and Imaging, "G. d'Annunzio" University, Chieti, Italy ; Aging Research Centre, Ce. S.I., "G. d'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Onofrj
authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors.forename: Sean J
authors.initials: SJ
authors.lastname: Colloby
authors.affiliation: Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Blamire
authors.affiliation: Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QC, UK.
authors.forename: John
authors.initials: J
authors.lastname: O'Brien
authors.affiliation: Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
mesh_terms: D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D009473:Neuronal Plasticity; D015203:Reproducibility of Results; D012146:Rest; D012680:Sensitivity and Specificity
keywords: Cognitive fluctuations; Dementia; Lewy bodies; Resting state network; Visual hallucinations