title: Effect of boron neutron capture therapy for recurrent anaplastic meningioma: an autopsy case report.
abstract: A 70-year-old woman died of systemic metastasis from anaplastic meningioma and underwent autopsy. The patient underwent twice total removal of the right sphenoid ridge meningioma 2 years ago. The tumor recurred 3 times, and then stereotactic radiotherapy was employed. Boron neutron capture therapy (BNCT) was performed for the fourth local recurrence and an additional new lesion. Proliferative activity of the newly developed meningioma, which had been treated with BNCT only, was significantly lower than that of untreated metastatic liver tumor, as well as that of the meningioma specimen obtained at the second surgery. Our pathological findings demonstrated, for the first time, the therapeutic effect of BNCT on anaplastic meningioma at an early stage (2.5 months).
authors.affiliation: Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaji
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Miyatake
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shinmura
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tokuyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Namba
mesh_terms: D000368:Aged; D001344:Autopsy; D016754:Boron Neutron Capture Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D008579:Meningioma / Q000473:pathology* / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016896:Treatment Outcome