title: Exploration of paclitaxel (Taxol) as a treatment for malignant tumors in cats: a descriptive case series.
abstract: Paclitaxel, an effective chemotherapeutic agent in human oncology, has received little evaluation in feline patients. The diluent used to solubilize paclitaxel, polyoxyethylated castor oil (Cremophor EL), causes anaphylactoid reactions in human and dogs, which limits enthusiasm for use of this agent in veterinary oncology. Nine feline patients with measurable malignant tumors were treated with paclitaxel at a dosage of 80 mg/m(2) intravenously every 21 days for up to two doses. Adverse effects, including evidence of toxicity and anaphylactoid reactions, were assessed. Tumor response, progression and patient time to progression (TTP) were also recorded. Adverse effects included grade III and IV thrombocytopenia, grade III gastrointestinal signs (vomiting and constipation) and hypersensitivity reactions, seen in a total of five patients. Anaphylactoid reactions resolved with appropriate management. Stable disease and partial response were observed in 56% of feline patients. Median TTP was 28 days (range 15-45 days). Intravenous paclitaxel is a safe treatment option for feline malignant tumor patients. Future investigation is warranted to explore the effectiveness and appropriate application of this agent for specific tumor types.
authors.affiliation: NorthStar VETS, Robbinsville, NJ, USA jkim@northstarvets.com.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kim
authors.affiliation: Michigan State University, East Lansing, MI, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Doerr
authors.affiliation: VCA Veterinary Care Animal Hospital and Referral Center, Albuquerque, NM, USA.
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Kitchell
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003967:Diarrhea / Q000662:veterinary; D004334:Drug Administration Schedule; D007262:Infusions, Intravenous / Q000662:veterinary; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D009503:Neutropenia / Q000662:veterinary; D017239:Paclitaxel / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000662:veterinary; D014839:Vomiting / Q000662:veterinary
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel