title: Corneal biomechanical properties measured by the ocular response analyzer in acromegalic patients.
abstract: OBJECTIVE
  To investigate the effect of acromegaly on corneal biomechanical parameters.
  
  
  METHODS
  This cross-sectional, comparative clinical study included 34 acromegalic patients and 30 age-matched and sex-matched healthy controls. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated and corneal-compensated intraocular pressure (IOPg and IOPcc, respectively) were measured using the Ocular Response Analyzer. Central corneal thickness (CCT) was determined with the ultrasonic pachymeter.
  
  
  RESULTS
  The mean duration of disease for the acromegalic patients was 5.3 years. There was no significant difference between the groups regarding mean CH, CRF, IOPg and IOPcc values. The respective mean values in patients with acromegaly and controls were 10.3 ± 2.2 and 9.5 ± 1.5 mmHg (p = 0.13) for CH; 10.5 ± 2.4 and 9.7 ± 1.7 mmHg (p = 0.16) for CRF, 16.1 ± 3.6 and 15.5 ± 2.9 mmHg (p = 0.49) for IOPg, 16.8 ± 3.4 and 17.0 ± 2.8 mmHg (p = 0.82) for IOPcc, and 544.8 ± 32.2 and 530.7 ± 22.9 μm (p = 0.05) for CCT. A significant moderate correlation was detected between the duration of acromegaly and IOPg OD (r = 0.430, p = 0.01). There was no significant correlation between other ocular parameters and levels of GH and IGF-1 at the time of diagnosis, the status of control, adenoma type, radiotherapy treatment, and drug usage.
  
  
  CONCLUSIONS
  In acromegalic patients, the duration of disease was correlated with IOPg OD level. Corneal biomechanical parameters and CCT values were not significantly different than those in age-matched and sex-matched healthy individuals.
authors.affiliation: Ulucanlar Eye Education and Research Hospital, Altındag, Ankara, Turkey, eminesentr@yahoo.com.
authors.forename: Emine
authors.initials: E
authors.lastname: Sen
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tutuncu
authors.forename: Melike
authors.initials: M
authors.lastname: Balikoglu-Yilmaz
authors.forename: Ufuk
authors.initials: U
authors.lastname: Elgin
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozturk
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000172:Acromegaly / Q000503:physiopathology*; D000328:Adult; D001696:Biomechanical Phenomena; D003315:Cornea / Q000502:physiology*; D063171:Corneal Pachymetry; D003430:Cross-Sectional Studies; D004548:Elasticity / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D015592:Immunoradiometric Assay; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014065:Tonometry, Ocular; D055815:Young Adult
chemical_list: D013006:Growth Hormone