title: Preoperative computed tomography does not predict resectability in peritoneal carcinomatosis.
abstract: BACKGROUND
  Obtaining a complete cytoreduction in patients with peritoneal carcinomatosis (PC) is one of the most significant prognostic variables for long-term survival. This study explored features on preoperative computed tomography (CT) to predict unresectability.
  
  
  METHODS
  A retrospective case-control study was conducted of 15 patients with unresectable PC and 15 patients with completely resected PC matched by intraoperative peritoneal cancer index (PCI) and pathology type. Two surgical oncologists blindly analyzed all abdominopelvic CT scans.
  
  
  RESULTS
  PCI estimated on imaging was not higher in unresectable patients (P = .851) and significantly underestimated intraoperative PCI measurement (P = .003). No single concerning feature was associated with unresectability. However, patients with 2 or more concerning features were more likely to be unresectable (87.5% vs 36.4%, P = .035).
  
  
  CONCLUSIONS
  Two or more concerning CT imaging features appear to be associated with a higher risk of unresectability in patients with PC. However, no specific imaging feature should exclude a patient from an attempted cytoreduction.
authors.affiliation: Department of Surgery and Oncology, University of Calgary, Calgary, Alberta, Canada. Electronic address: Justin.Rivard@albertahealthservices.ca.
authors.forename: Justin D
authors.initials: JD
authors.lastname: Rivard
authors.affiliation: Department of Surgery and Oncology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Walley J
authors.initials: WJ
authors.lastname: Temple
authors.affiliation: Department of Surgery and Oncology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Yarrow J
authors.initials: YJ
authors.lastname: McConnell
authors.affiliation: Department of Surgery and Oncology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Hisham
authors.initials: H
authors.lastname: Sultan
authors.affiliation: Department of Surgery and Oncology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Lloyd A
authors.initials: LA
authors.lastname: Mack
mesh_terms: D001063:Appendiceal Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000601:surgery; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000473:pathology; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008654:Mesothelioma / Q000473:pathology; D008875:Middle Aged; D018579:Patient Selection; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000601:surgery; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
keywords: Computed tomography; Cytoreduction; Peritoneal carcinomatosis; Resectability