title: Prognostic analysis and comparison of colon cancer in Han and Hui patients.
abstract: OBJECTIVE
  To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region.
  
  
  METHODS
  A retrospective analysis of 880 patients diagnosed with CRC at Xuanwu Hospital, Capital Medical University between September 2001 and September 2011 was performed. Among the 880 patients, 398 and 482 were Hui and Han, respectively. Characteristics including sex, age, diet, tumor size, primary tumor site, Dukes' stage and degree of differentiation were analyzed for their influence on prognosis. Data on dietary structures were recorded through a questionnaire survey conducted during the patient's first visit, return visit or follow-up checkups.
  
  
  RESULTS
  Among patients with colon cancer, the 5-year survival rate for patients of Hui ethnicity was lower than that for Han patients (P = 0.025). Six risk factors (age of onset, dietary structure, tumor size, Dukes' stage, location of cancer and degree of differentiation) in both Han and Hui patients were identified as prognostic factors (P < 0.05). Multivariate analysis showed that age of onset (P = 0.002), diet (P = 0.000), Dukes' stage (P = 0.000) and degree of differentiation (P = 0.000) are prognostic factors affecting both ethnic groups. Comparison of prognostic factors between Han and Hui patients with CRC showed that dietary structure was a statistically significant factor, and diet varied significantly between the two ethnic groups.
  
  
  CONCLUSIONS
  Dietary structure has a significant influence on colon cancer prognosis among Han and Hui patients with colon cancer in Beijing, which may cause a difference in their survival rates.
authors.affiliation: Mei Zhang, Qu-Chuan Zhao, Yan-Peng Liu, Lei Yang, Hong-Ming Zhu, Jagadish K Chhetri, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Mei Zhang, Qu-Chuan Zhao, Yan-Peng Liu, Lei Yang, Hong-Ming Zhu, Jagadish K Chhetri, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Qu-Chuan
authors.initials: QC
authors.lastname: Zhao
authors.affiliation: Mei Zhang, Qu-Chuan Zhao, Yan-Peng Liu, Lei Yang, Hong-Ming Zhu, Jagadish K Chhetri, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Yan-Peng
authors.initials: YP
authors.lastname: Liu
authors.affiliation: Mei Zhang, Qu-Chuan Zhao, Yan-Peng Liu, Lei Yang, Hong-Ming Zhu, Jagadish K Chhetri, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: Mei Zhang, Qu-Chuan Zhao, Yan-Peng Liu, Lei Yang, Hong-Ming Zhu, Jagadish K Chhetri, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Zhu
authors.affiliation: Mei Zhang, Qu-Chuan Zhao, Yan-Peng Liu, Lei Yang, Hong-Ming Zhu, Jagadish K Chhetri, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Jagadish K
authors.initials: JK
authors.lastname: Chhetri
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002454:Cell Differentiation; D002681:China / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000208:ethnology* / Q000401:mortality / Q000473:pathology*; D004032:Diet / Q000009:adverse effects / Q000208:ethnology*; D005247:Feeding Behavior / Q000208:ethnology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D047368:Tumor Burden
keywords: Colon cancer; Colorectal cancer; Han patients; Hui patients; Multivariate analysis; Prognosis