title: Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
abstract: Bio-based high elastic polyurethanes were prepared from hexamethylene diisocyanate and various ratios of isosorbide to poly(tetramethylene glycol) as a diol by a simple one-shot bulk polymerization without a catalyst. Successful synthesis of the polyurethanes was confirmed by Fourier transform-infrared spectroscopy and (1)H nuclear magnetic resonance. Thermal properties were determined by differential scanning calorimetry and thermogravimetric analysis. The glass transition temperature was -47.8℃. The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers. The static and dynamic properties of the polyether/isosorbide-based thermoplastic elastomer were more suitable for dynamic applications. Moreover, such rigid diols impart biocompatible and bioactive properties to thermoplastic polyurethane elastomers. Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss. These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.
authors.forename: Min-Sil
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea msgong@dankook.ac.kr.
authors.forename: Myoung-Seon
authors.initials: MS
authors.lastname: Gong
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D007547:Isosorbide / Q000737:chemistry*; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D011092:Polyethylene Glycols; D007547:Isosorbide
keywords: Isosorbide; biocompatibility; biopolymer; polyurethane; thermoplastic elastomer