title: [Chronic myeloid leukemia stem cells: cross-talk with the niche].
abstract: The physiological hematopoietic niche located in bone marrow is a pluricellular structure whose components are now well identified. Within this microenvironment, hematopoietic stem cells are in direct contact with mesenchymal stromal cells, osteoblasts and sinusoidal endothelial cells. These close relationships drive specialized cellular functions (proliferation/quiescence, differentiation/self-renewal) ensuring an efficient hematopoiesis. Chronic myeloid leukemia (CML) is a major model of leukemic hematopoiesis. The BCR-ABL1 tyrosine kinase, constitutively activated in CML, plays a critical role in the pathogenesis of the disease. An intensive cross-talk between CML progenitors and the components of the hematopoietic niche has recently been demonstrated. Consequently, the occurrence of the so-called leukemic niche promotes both the proliferation of myeloid cells and the maintenance of quiescent leukemic stem cells. This bone marrow niche could also protect CML stem cells from tyrosine kinase inhibitors and probably contribute to their resistance towards targeted therapies.
authors.affiliation: Service de cancérologie biologique, CHU de Poitiers, Poitiers, France - Inserm U935, université de Poitiers, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Chomel
authors.affiliation: Inserm U935, université de Poitiers, France.
authors.forename: Djamel
authors.initials: D
authors.lastname: Aggoune
authors.affiliation: Service de cancérologie biologique, CHU de Poitiers, Poitiers, France - Inserm U935, université de Poitiers, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sorel
authors.affiliation: Inserm U935, université de Poitiers, France - hôpitaux universitaires Paris-Sud, le Kremlin Bicêtre, France - Inserm U935, université Paris-Sud 11, Paris, France.
authors.forename: Ali G
authors.initials: AG
authors.lastname: Turhan
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D006413:Hematopoietic System / Q000502:physiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000502:physiology*