title: La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiff's base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA).
abstract: The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiff's bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiff's base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiff's base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiff's base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiff's base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice.
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, Karnataka, India. Electronic address: siddappa_65@rediffmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Siddappa
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, Karnataka, India.
authors.forename: Sunilkumar B
authors.initials: SB
authors.lastname: Mane
authors.affiliation: Department of Microbiology, Gulbarga University, Gulbarga 585 106, Karnataka, India.
authors.forename: Deene
authors.initials: D
authors.lastname: Manikprabhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006358:Hot Temperature; D007194:India; D007811:Lanthanum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D009584:Nitrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D052999:Quinazolinones / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: C000594892:3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one; D000900:Anti-Bacterial Agents; D052999:Quinazolinones; D012545:Schiff Bases; D007811:Lanthanum; D009584:Nitrogen; D010100:Oxygen
keywords: Antimicrobial activity; Methicillin-resistant Staphylococcus aureus; Quinazoline-4(3H)-one