title: The immune landscape of human tumors: Implications for cancer immunotherapy.
abstract: Understanding the spontaneous immune response of cancer patients is critical for the design of efficient anticancer immunotherapies. The power of integrative tumor immunology approaches allowed for a comprehensive view of the immune system evolution in the course of tumor progression and recurrence. We have demonstrated that tumor-infiltrating immune cells are spatiotemporally regulated, a finding that has profound implications for the development of efficient anticancer immunotherapies.
authors.affiliation: INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Bindea
authors.affiliation: INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Mlecnik
authors.affiliation: INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France ; Molecular Pathology Group; AstraZeneca; Alderley Park; Cheshire, UK.
authors.forename: Helen K
authors.initials: HK
authors.lastname: Angell
authors.affiliation: INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Galon
keywords: bioinformatics; cancer; immune landscape; immunoscore; prognosis