title: A 4D dose computation method to investigate motion interplay effects in scanned ion beam prostate therapy.
abstract: In particle therapy, the interplay between beam scanning and target motion during treatment delivery may result in dose deterioration. Interplay effects have been studied for targets exhibiting periodic respiratory motion, however, they are not well understood for irregular motion patterns, such as those exhibited by the prostate. In this note, we propose and validate a 4D dose computation method, which enables estimation of effective dose delivered to the prostate by scanning ion beams in presence of intrafraction motion, as well as facilitates investigation of various motion interplay countermeasures.
authors.forename: F
authors.initials: F
authors.lastname: Ammazzalorso
authors.forename: U
authors.initials: U
authors.lastname: Jelen
mesh_terms: D019583:Dose Fractionation, Radiation; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D008297:Male; D009068:Movement; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D013997:Time Factors