title: Gene-environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men.
abstract: OBJECTIVE
  A single nucleotide polymorphism, rs10486567, in JAZF1 has consistently been associated with increased risk of prostate cancer. The physical interaction of zinc finger proteins, such as JAZF1, with heavy metals may play a role in carcinogenesis. This study assessed potential gene-environment statistical interactions (G×E) between rs10486567 and heavy metals in prostate cancer.
  
  
  METHODS
  In a case-only study of 228 African American prostate cancer cases, G×E between rs10486567 and sources of cadmium and lead (Pb) were assessed. Unconditional logistic regression was used to estimate interaction odds ratios (IORs), and generalized estimating equations were used for models containing nested data. Case-control validation of IORs was performed, using 82 controls frequency matched to cases on age-race.
  
  
  RESULTS
  Among cases, a potential G×E interaction was observed between rs10486567 CC genotype and living in a Census tract with a high proportion of housing built before 1950, a proxy for household Pb exposure, when compared to CT or TT carriers (OR 1.81; 95% CI 1.04-3.16; p = 0.036). A stronger G×E interaction was observed when both housing and occupational Pb exposure were taken into account (OR 2.62; 95% CI 1.03-6.68; p = 0.04). Case-control stratified analyses showed the odds of being a CC carrier were higher in cases compared to controls among men living in areas with older housing (OR 2.03; CI 0.99-4.19; p = 0.05) or having high occupational Pb exposure (OR 2.50; CI 1.01-6.18; p = 0.05).
  
  
  CONCLUSIONS
  In African American men, the association between JAZF1 rs10486567 and prostate cancer may be modified by exposure to heavy metals such as Pb.
authors.affiliation: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA, cdudas1@hfhs.org.
authors.forename: Christine
authors.initials: C
authors.lastname: Neslund-Dudas
authors.forename: Albert M
authors.initials: AM
authors.lastname: Levin
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Beebe-Dimmer
authors.forename: Cathryn H
authors.initials: CH
authors.lastname: Bock
authors.forename: Nora L
authors.initials: NL
authors.lastname: Nock
authors.forename: Andrew
authors.initials: A
authors.lastname: Rundle
authors.forename: Michelle
authors.initials: M
authors.lastname: Jankowski
authors.forename: Richard
authors.initials: R
authors.lastname: Krajenta
authors.forename: Q Ping
authors.initials: QP
authors.lastname: Dou
authors.forename: Bharati
authors.initials: B
authors.lastname: Mitra
authors.forename: Deliang
authors.initials: D
authors.lastname: Tang
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Rybicki
mesh_terms: D001741:Black or African American; D000368:Aged; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007854:Lead / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics
chemical_list: D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; C430460:JAZF1 protein, human; D009363:Neoplasm Proteins; D007854:Lead