title: Synthesis, characterization, and biological activities of two Cu(II) and Zn(II) complexes with one polyquinoline ligand.
abstract: Two new complexes, [CuLCl]ClO4 (1) and [Zn2L2SO4(H2O)2](ClO4)2 (2) [L=N,N-bis(quinolin-2-ylmethyl)quinolin-8-amine], have been synthesized and structurally characterized. The interactions of two complexes with CT-DNA have been investigated by UV absorption, fluorescence spectroscopy, viscosity measurements and gel electrophoresis under physiological conditions. Results show that the complexes bind to CT-DNA with a moderate intercalative mode and exhibit efficient DNA cleavage activity on UV-A light of 365 nm. Furthermore, two complexes could quench the intrinsic fluorescence of BSA in a static quenching process based on BSA binding experiments. Notably, in vitro cytotoxicity study of two complexes on four human tumor cells lines (7404, HeLa, MCF-7, and HepG-2) indicate that both of them have the potential to act as effective anticancer drugs with low IC50 values.
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China.
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Li
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China. Electronic address: liuxin64@nankai.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China. Electronic address: tiant@nankai.edu.cn.
authors.forename: Jin-Lei
authors.initials: JL
authors.lastname: Tian
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, PR China; State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, PR China.
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D002417:Cattle; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007364:Intercalating Agents / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D061986:MCF-7 Cells; D011485:Protein Binding; D011804:Quinolines / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D014466:Ultraviolet Rays; D014783:Viscosity; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007364:Intercalating Agents; D008024:Ligands; D011804:Quinolines; D012710:Serum Albumin, Bovine; D003300:Copper; D004247:DNA; D015032:Zinc
keywords: A static quenching process; Antitumor activity; DNA binding; Photo-induced DNA cleavage; Polyquinoline ligand