title: The Cj0588 protein is a Campylobacter jejuni RNA methyltransferase.
abstract: TlyA proteins belong to 2'-O-methyltransferases. Methylation is a common posttranscriptional RNA modification. The Campylobacter jejuni Cj0588 protein belongs to the TlyA(I) protein family and is a rRNA methyltransferase. Methylation of ribosomal RNA catalyzed by Cj0588 appears to have an impact on the biology of the cell. Presence of the cj0588 gene in bacteria appears to be important for ribosome stability and virulence properties. Absence of the Cj0588 protein causes accumulation of the 50S ribosomal subunits, reduction in the amount of functional 70S ribosomes and confers increase resistance to capreomycin.
authors.affiliation: Division of Microbiology, Department of Pre-Clinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Live Sciences - SGGW, Ciszewskiego 8, 02-786 Warsaw, Poland. Electronic address: agnieszka_salamaszynska_guz@sggw.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sałamaszyńska-Guz
authors.affiliation: Division of Physiology, Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Live Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Taciak
authors.affiliation: Department of Virology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kwiatek
authors.affiliation: Division of Microbiology, Department of Pre-Clinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Live Sciences - SGGW, Ciszewskiego 8, 02-786 Warsaw, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Klimuszko
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016123:Campylobacter jejuni / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D002207:Capreomycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D008745:Methylation; D008780:Methyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011132:Polyribosomes / Q000378:metabolism; D011487:Protein Conformation; D012329:RNA, Bacterial / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D002207:Capreomycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase
keywords: Campylobacter jejuni; Methyltransferase; Ribosome