title: Pregabalin in the treatment of inferior alveolar nerve paraesthesia following overfilling of endodontic sealer.
abstract: A case of orofacial pain and inferior alveolar nerve (IAN) paraesthesia after extrusion of endodontic sealer within the mandibular canal treated with prednisone and pregabalin is described. A 36-year-old woman underwent root canal treatment of the mandibular second right premolar tooth. Post-operative panoramic radiograph revealed the presence of radiopaque canal sealer in the mandibular canal. Damage to IAN consecutive to extrusion of endodontic sealer was diagnosed. Non-surgical management was decided, including: 1 mg/kg/day prednisone 2 times/day, once-daily regimen, and 150 mg/day pregabalin, two doses per day, monitoring the progress with periodic follow-up visits. Six weeks after the incident the signs and symptoms were gone. The complete resolution of paraesthesia and the control of pain achieved suggest that a non-surgical approach, combining prednisone and the GABA analogue pregabalin, is a good option in the management of the IAN damage subsequent to endodontic sealer extrusion. Key words:Endodontics, inferior alveolar nerve, neuropathic pain, orofacial pain, paraesthesia, pregabalin.
authors.affiliation: Associate Professor. Department of Endodontics, School of Dentistry, University of Zaragoza, 22006-Huesca, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Alonso-Ezpeleta
authors.affiliation: Doctoral fellow. Department of Stomatology, School of Dentistry, University of Sevilla, C/ Avicena s/n, 41009-Sevilla, Spain.
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Martín
authors.affiliation: Professor. Department of Odontostomatology, University of Barcelona, Barcelona, Spain.
authors.forename: José
authors.initials: J
authors.lastname: López-López
authors.affiliation: Doctoral fellow. Department of Stomatology, School of Dentistry, University of Sevilla, C/ Avicena s/n, 41009-Sevilla, Spain.
authors.forename: Lizett
authors.initials: L
authors.lastname: Castellanos-Cosano
authors.affiliation: Doctoral fellow. Department of Stomatology, School of Dentistry, University of Sevilla, C/ Avicena s/n, 41009-Sevilla, Spain.
authors.forename: Jenifer
authors.initials: J
authors.lastname: Martín-González
authors.affiliation: Full Professor. Department of Endodontics, School of Dentistry, University of Sevilla, C/ Avicena s/n, 41009-Sevilla, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Segura-Egea