title: ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
abstract: Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL patients were evaluated by DWI and DTI in a large cohort study over a 6-year period. ADC histogram parameters were compared to those derived from mean diffusivity (MD) histograms in 280 patients using intra-class correlation and Bland-Altman plots. Impact of image corrections applied to ADC maps was assessed and a mixed effect model was used for analyzing the effects of scanner upgrades. The results showed that ADC histogram parameters are strongly correlated to MD histogram parameters and that image corrections have only limited influence on these results. Unexpectedly, scanner upgrades were found to have major effects on diffusion measures with DWI or DTI that can be even larger than those related to patients' characteristics. These data support that ADC histograms from daily used DWI can provide relevant parameters for assessing cSVD, but the variability related to scanner upgrades as regularly performed in clinical centers should be determined precisely for longitudinal and multicentric studies using diffusion MRI in cSVD.
authors.affiliation: Department of Neurology, Semmelweis University, Budapest, Hungary; Department of Neurology, CHU Lariboisière, DHU NeuroVasc, APHP and Université Paris Denis-Diderot, Paris, France.
authors.forename: Bence
authors.initials: B
authors.lastname: Gunda
authors.affiliation: Université Paris Descartes, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Porcher
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Duering
authors.affiliation: Department of Neuroradiology, CHU Lariboisière, DHU NeuroVasc, APHP and Université Paris Denis-Diderot, Paris, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Guichard
authors.affiliation: Department of Neurology, CHU Lariboisière, DHU NeuroVasc, APHP and Université Paris Denis-Diderot, Paris, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Mawet
authors.affiliation: INSERM UMR 1161, Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Jouvent
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
authors.affiliation: Department of Neurology, CHU Lariboisière, DHU NeuroVasc, APHP and Université Paris Denis-Diderot, Paris, France; INSERM UMR 1161, Paris, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
mesh_terms: D046589:CADASIL / Q000175:diagnosis*; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008297:Male; D011336:Probability