title: Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors.
abstract: Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.
authors.affiliation: Biomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC, United States; Department of Life Sciences, Winston-Salem State University, Winston Salem, NC, United States; Department of Obstetrics & Gynecology, Wake Forest University School of Medicine, Winston Salem, NC, United States; Hypertension Research & Vascular Center, Wake Forest University School of Medicine, Winston Salem, NC, United States. Electronic address: vpulgar@wakehealth.edu.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Pulgar
authors.affiliation: Biomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC, United States; Department of Life Sciences, Winston-Salem State University, Winston Salem, NC, United States; Physiology & Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, United States.
authors.forename: Jill
authors.initials: J
authors.lastname: Keith Harp
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008638:Mesenteric Arteries / Q000187:drug effects*; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011189:Potassium Chloride / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001559:Benzhydryl Compounds; D018765:Dopamine Uptake Inhibitors; D010880:Piperidines; D011189:Potassium Chloride; D009638:Norepinephrine
keywords: Arterial contraction; Dopamine transporter; Piperidinol-4