title: The effects of nitroglycerin, norepinephrine and aminophylline on intrapulmonary arteriovenous anastomoses in healthy humans at rest.
abstract: We have investigated the effects of the intravenous infusion of nitroglycerin (NTG), norepinephrine (NE) and aminophylline (AMP) on the opening and recruitment of intrapulmonary arteriovenous anastomoses (IPAVA) in healthy humans at rest. In ten volunteers saline contrast echocardiography was performed during administration of two doses of the NTG (3μgkg(-1)min(-1) and 6μgkg(-1)min(-1)) and NE (0.1μgkg(-1)min(-1) and 0.25μgkg(-1)min(-1)) as well as 30min following the administration of AMP at rate of 6mgkg(-1). Echocardiography was used to assign bubble scores (0-5) based on the number and spatial distribution of bubbles in the left ventricle. Doppler ultrasound was used to estimate pulmonary artery systolic pressure. Using a Finometer the following hemodynamic parameters were assessed: heart rate, stroke volume, cardiac output, total peripheral resistance as well as systolic, diastolic and mean arterial pressure. The most important finding from the current study was that nitroglycerin, norepinephrine and aminophylline in the applied doses were not found to promote IPAVA opening in healthy humans at rest.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University Hospital Centre Split, Spinciceva 1, 21000 Split, Croatia.
authors.forename: Mislav
authors.initials: M
authors.lastname: Lozo
authors.affiliation: Department of Anesthesiology, University Hospital Centre Split, Spinciceva 1, 21000 Split, Croatia.
authors.forename: Mihajlo
authors.initials: M
authors.lastname: Lojpur
authors.affiliation: Department of Integrative Physiology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia.
authors.forename: Dennis
authors.initials: D
authors.lastname: Madden
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University Hospital Centre Split, Spinciceva 1, 21000 Split, Croatia.
authors.forename: Petar
authors.initials: P
authors.lastname: Lozo
authors.affiliation: Department of Integrative Physiology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Banic
authors.affiliation: Department of Integrative Physiology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia. Electronic address: zeljko.dujic@mefst.hr.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Dujic
mesh_terms: D000328:Adult; D000628:Aminophylline / Q000494:pharmacology*; D062186:Arterial Pressure / Q000187:drug effects; D001163:Arteriovenous Anastomosis / Q000187:drug effects* / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D004452:Echocardiography; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D012146:Rest; D013318:Stroke Volume / Q000187:drug effects; D018608:Ultrasonography, Doppler; D016276:Ventricular Function
chemical_list: D002317:Cardiovascular Agents; D000628:Aminophylline; D005996:Nitroglycerin; D009638:Norepinephrine
keywords: Aminophylline; Cardiac output; IPAVA; Nitroglycerin; Norepinephrine; Pulmonary artery pressure