title: Genetic of gonadal determination.
abstract: Fetal sexual differentiation results from complex subsequent intracellular signaling and hormonal events that interact together in a definite timing. This process contributes to the setting of gonad determination, internal and external genitalia resulting in a female or male phenotype. Here, we review our current knowledge of gonadal determination drawing on insights from knock-out and transgenic mouse models and analysis of patients with disorders of sex development (DSD).
authors.affiliation: Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France. Electronic address: yves.morel@chu-lyon.fr.
authors.forename: Yves
authors.initials: Y
authors.lastname: Morel
authors.affiliation: Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Roucher
authors.affiliation: Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Mallet
authors.affiliation: Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Plotton
mesh_terms: D000818:Animals; D019070:Cell Lineage; D012734:Disorders of Sex Development / Q000196:embryology / Q000235:genetics / Q000503:physiopathology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010053:Ovary / Q000166:cytology / Q000196:embryology*; D010641:Phenotype; D055758:SOX9 Transcription Factor / Q000502:physiology; D019849:Sex Determination Processes; D012733:Sex Differentiation / Q000502:physiology*; D051876:Sex-Determining Region Y Protein / Q000502:physiology; D013737:Testis / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology
chemical_list: D055758:SOX9 Transcription Factor; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors
keywords: Différenciation sexuelle; Disorders of sex development; Détermination gonadique; Gonad determination; Human gene mutation; Pathologie humaine; Sex determination; Souris transgénique; Transgenic mouse models