title: Long-term clinical outcomes after everolimus- and sirolimus-eluting coronary stent implantation: final 3-year follow-up of the Randomized Evaluation of Sirolimus-Eluting Versus Everolimus-Eluting Stent Trial.
abstract: BACKGROUND
  Long-term clinical outcomes of everolimus-eluting stent (EES) compared with sirolimus-eluting stent (SES) have not been evaluated fully yet, especially whether EES implantation could positively affect late adverse events reported after SES implantation occurring >1 year.
  
  
  RESULTS
  In this all-comer prospective multicenter randomized open-label trial, 3196 patients were assigned randomly to implant either EES (n=1596) or SES (n=1600). At 3 years, EES was noninferior to SES on the primary safety end point (all-cause death or myocardial infarction; 10.1% versus 11.5%; noninferiority P <0.001; and superiority P=0.19). Cumulative incidence of definite stent thrombosis was low and was not significantly different between the 2 groups (0.5% versus 0.6%; P=0.81). There was no significant difference in the efficacy end point of target-lesion revascularization between the EES and SES groups (6.6% versus 7.9%; P=0.16). However, the cumulative incidence of target-lesion failure (cardiac death/target-vessel myocardial infarction/ischemia-driven target-lesion revascularization) was significantly lower in the EES group than in the SES group (8.8% versus 11.4%; P=0.01). By a landmark analysis at 1 year, the cumulative incidence of very late stent thrombosis and late target-lesion revascularization was not significantly different between the 2 groups (0.2% versus 0.2%; P=0.99 and 2.2% versus 2.9%; P=0.21, respectively).
  
  
  CONCLUSIONS
  The efficacy and safety outcomes for this trial after EES implantation remained comparable with those after SES implantation through 3-year follow-up. However, improvement of clinical outcome after EES implantation compared with SES implantation was suggested by the significantly lower cumulative incidences of target-lesion failure, which has been the most widely used primary end point in the stent-versus-stent trials.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov. Unique identifier: NCT01035450.
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shiomi
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Ken
authors.initials: K
authors.lastname: Kozuma
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Keiichi
authors.initials: K
authors.lastname: Igarashi
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kadota
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Kengo
authors.initials: K
authors.lastname: Tanabe
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morino
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Takashi
authors.initials: T
authors.lastname: Akasaka
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Abe
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Satoru
authors.initials: S
authors.lastname: Suwa
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Toshiya
authors.initials: T
authors.lastname: Muramatsu
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Kazuoki
authors.initials: K
authors.lastname: Dai
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakao
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Masaaki
authors.initials: M
authors.lastname: Uematsu
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tarutani
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Kenshi
authors.initials: K
authors.lastname: Fujii
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.).
authors.forename: Charles A
authors.initials: CA
authors.lastname: Simonton
authors.affiliation: From the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (H.S., T.K.); Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma); Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T. Morimoto); Department of Cardiology, Hokkaido Social Insurance Hospital, Sapporo, Japan (K.I.); Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan (K. Kadota); Department of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K.T.); Department of Cardiology, Iwate University Hospital, Morioka, Japan (Y.M.); Department of Cardiovascular Medicine, Wakayama Medical University Hospital, Wakayama, Japan (T.A.); Department of Cardiology, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan (M.A.); Department of Cardiology, Juntendo University Shizuoka Hospital, Nagaoka, Japan (S.S.); Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan (T. Muramatsu); Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan (M.K.); Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan (K.D.); Department of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan (K.N.); Department of Cardiology, Kansai Rosai Hospital, Cardiovascular Center, Hyogo, Japan (M.U.); Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan (Y.T.); Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan (K.F.); and Abbott Vascular, Abbott Park, IL (C.A.S.). taketaka@kuhp.kyoto-ua.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000368:Aged; D023903:Coronary Restenosis / Q000453:epidemiology; D023921:Coronary Stenosis / Q000628:therapy*; D054855:Drug-Eluting Stents; D000068338:Everolimus; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011446:Prospective Studies; D020123:Sirolimus / Q000031:analogs & derivatives*; D013927:Thrombosis / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000068338:Everolimus; D020123:Sirolimus
keywords: coronary restenosis; thrombosis