title: [Effect of byetta on renal osmoregulatory function in patients with diabetes mellitus].
abstract: The renal osmoregulatory function was studied in patients with type 2 diabetes mellitus (DM). The renal response to water loading (0.7% b.w.) and simultaneous exenatide (byetta) injection (5 microg) exhibited variation and was dependent on the degree of hyperglycemia. Effective solute-free water excretion was observed in patients with well-controlled DM (HbAlc 6.0 +/- 0.1%), in which CH20 changed from -0.67 +/- 0.2 mL/min to 0.72 +/- 0.2 mL/min. This reaction was absent in patients with poorly controlled DM (HbAlc 8.8 +/- 0.6%) and the process of solute-free water reabsorption prevailed: -CH20 = -1.06 +/- 0.1 mL/min in control period vs. -0.99 +/- 0.1 mL/min after treatment. Thus, byetta increases the efficiency of osmoregulation and accelerates the excretion of excess water in patients with compensated carbohydrate metabolism.
authors.forename: E I
authors.initials: EI
authors.lastname: Shakhmatova
authors.forename: E V
authors.initials: EV
authors.lastname: Pimenova
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Shchutskaia
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D000077270:Exenatide; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D064587:Osmoregulation / Q000187:drug effects*; D010455:Peptides / Q000627:therapeutic use*; D014688:Venoms / Q000627:therapeutic use*; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D000077270:Exenatide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D010455:Peptides; D014688:Venoms; D014867:Water; C517652:hemoglobin A1c protein, human