title: Changes in current-source density of interictal spikes in benign epilepsy of childhood with centrotemporal spikes following treatment with oxcarbazepine.
abstract: OBJECTIVE
  The aim of this study was to detect clinical variables associated with the extent of change of the irritative zone in benign epilepsy of childhood with centrotemporal spikes (BECTS) after oxcarbazepine monotherapy.
  
  
  METHODS
  BECTS patients receiving oxcarbazepine monotherapy were retrospectively reviewed. Changes in current-source density (CSD) of the maximum negative points of interictal spikes prior to the start of oxcarbazepine treatment were compared with CSD following oxcarbazepine treatment for 6-12 months. CSD was measured using low-resolution brain electromagnetic tomography (LORETA). Patients were divided into two groups based on the change in CSD: increased-extent or decreased-extent. Comparisons were made between the groups based on the age of onset, seizure frequency before treatment, time interval between seizure onset and treatment start, time interval between the two EEGs, oxcarbazepine dosage at the follow-up electroencephalography, occurrence of daytime seizures, and seizure control.
  
  
  RESULTS
  Fourteen patients were enrolled. Seven patients were in the decreased-extent group and six in the increased-extent group; one patient was excluded because she did not demonstrate any change in CSD. We found that seizure control differed significantly between the two groups: seizures were well-controlled in six out of seven patients in the decreased-extent group (85.7%), but in only one of six patients (16.7%) in the increased-extent group (p=0.03). The other variables did not differ between the groups.
  
  
  CONCLUSIONS
  Seizure control may be associated with the extent of changes in the neuronal irritative zones of BECTS patients. We suggest that changes of CSD extent may be used as an imaging modality to evaluate clinical improvement in BECTS patients.
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea; Gyeonsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Jung Sook
authors.initials: JS
authors.lastname: Yeom
authors.affiliation: Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Seokwon
authors.initials: S
authors.lastname: Jung
authors.affiliation: Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea. Electronic address: mnkwon21@daum.net.
authors.forename: Oh-Young
authors.initials: OY
authors.lastname: Kwon
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D058256:Brain Waves / Q000502:physiology*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000078330:Oxcarbazepine; D012189:Retrospective Studies
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine
keywords: Benign epilepsy of childhood with centrotemporal spikes; Current-source analysis; Electroencephalography; Interictal spikes; Oxcarbazepine