title: Noninvasive assessment of cerebral artery stenoses from anatomic computed tomography angiography.
abstract: Trans-stenotic pressure gradient (TSPG) and fractional flow reserve (FFR) are well-validated hemodynamic indices to assess the ischemic severity of arterial stenoses. However, they have significant restrictions in practice due to invasiveness and high cost. Recently, a noninvasive assessment of FFR from computed tomography (CT) angiography has been well validated in evaluating functional coronary stenoses. We present a case of a 65-year-old woman with cerebral artery stenoses demonstrated by clinical symptoms, transcranial Doppler ultrasound and CT angiography, aiming to transplant the noninvasive functional diagnosis, for the first time, to cerebral artery stenoses and test a computational workflow of noninvasive TSPG and FFR.
authors.affiliation: Institute of Digestive Disease, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Qi
authors.affiliation: Institute of Digestive Disease, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Fangyu
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Division of Interventional Radiology, Shanghai Jing'an District Central Hospital, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.affiliation: Division of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Institute of Digestive Disease, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Institute of Digestive Disease, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Division of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Division of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Wanrong
authors.initials: W
authors.lastname: Ma
authors.affiliation: Institute of Digestive Disease, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Ji
authors.affiliation: Institute of Digestive Disease, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Yang
keywords: cerebral artery stenoses; fractional flow reserve; noninvasive; trans-stenotic pressure gradient