title: Haematological parameters and serum trace elements in "healthy" and "unhealthy" morbidly obese patients before and after gastric bypass.
abstract: OBJECTIVE
  We have investigated the differences in plasma parameters and serum trace elements between "healthy" and unhealthy morbidly obese patients before and after Roux-en-Y gastric bypass surgery.
  
  
  METHODS
  A group of 32 morbidly obese patients undergoing bariatric surgery were divided into three groups. Group 1 subjects were free of dyslipidemia and type II diabetes mellitus (defined as "healthy" obese, DM-DL-); Group 2 subjects had only the presence of dyslipidemia (DM-DL+), while group 3 patients demonstrated the presence of both (DM + DL+). In all patients, we studied haematological, haemostasis, anaemia, coagulation plasma and trace elements parameters before and 1, 6 and 12 months after gastric bypass surgery.
  
  
  RESULTS
  We found significant differences in some haematological parameters, including haemostasis (e.g., T-Quick, p = 0.0048) and coagulation (e.g., ATIII and PAI-1, p = 0.001 and p < 0.0001, respectively) and in anaemia parameters (e.g., folate, cobalamin and transferrin, p = 0.0002, p < 0.0001 and p = 0.0001, respectively) but also in serum trace elements between the groups. However, the response to bariatric surgery was similar in the three groups.
  
  
  CONCLUSIONS
  Any healthy morbid obese subject is really metabolically "unhealthy" because he or she has many other haematologic or serum abnormalities that are often not included in the criteria for the definition of "healthy" in these obese subjects.
authors.affiliation: Biochemistry Department, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Ferrer
authors.affiliation: Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028 Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Pardina
authors.affiliation: Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028 Barcelona, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Rossell
authors.affiliation: Arnau de Vilanova University Hospital (UdL), Surgery Unit, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Baena-Fustegueras
authors.affiliation: Endocrinology and Nutrition Department at Arnau de Vilanova University Hospital (UdL) and Diabetes and Metabolism Research Unit (VHIR, UAB) and CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM) at the Instituto de Salud Carlos III, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Lecube
authors.affiliation: Endocrinology Surgery Unit, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Balibrea
authors.affiliation: Endocrinology Surgery Unit, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: Enric
authors.initials: E
authors.lastname: Caubet
authors.affiliation: Endocrinology Surgery Unit, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: González
authors.affiliation: Endocrinology Surgery Unit, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Vilallonga
authors.affiliation: Endocrinology Surgery Unit, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Fort
authors.affiliation: Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028 Barcelona, Spain. Electronic address: jpeinado@ub.edu.
authors.forename: Julia
authors.initials: J
authors.lastname: Peinado-Onsurbe
mesh_terms: D000328:Adult; D000740:Anemia / Q000097:blood; D001779:Blood Coagulation Factors / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000009:adverse effects* / Q000379:methods; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009767:Obesity, Morbid / Q000453:epidemiology / Q000601:surgery*; D013997:Time Factors; D014131:Trace Elements / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; D014131:Trace Elements
keywords: Bariatric surgery; Diabetes; Dyslipidemia; Haematology; Haemostasis; Healthy obese