title: Amiodarone induced hyponatremia masquerading as syndrome of inappropriate antidiuretic hormone secretion by anaplastic carcinoma of prostate.
abstract: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most common causes of hyponatremia. The usual causes are malignancies, central nervous system, pulmonary disorders, and drugs. Amiodarone is a broad spectrum antiarrhythmic agent widely used in the management of arrhythmias. The different side effects include thyroid dysfunction, visual disturbances, pulmonary infiltrates, ataxia, cardiac conduction abnormalities, drug interactions, corneal microdeposits, skin rashes, and gastrointestinal disturbances. SIADH is a rare but lethal side effect of amiodarone. We describe a 62-year-old male who was suffering from advanced prostatic malignancy, taking amiodarone for underlying heart disease. He developed SIADH which was initially thought to be paraneoplastic in etiology, but later histopathology refuted that. This case emphasizes the importance of detailed drug history and the role of immunohistochemistry in establishing the diagnosis and management of hyponatremia due to SIADH.
authors.affiliation: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Nehru Hospital, 4th Floor, F Block, Chandigarh 160012, India.
authors.forename: Pinaki
authors.initials: P
authors.lastname: Dutta
authors.affiliation: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Nehru Hospital, 4th Floor, F Block, Chandigarh 160012, India.
authors.forename: Girish
authors.identifier: 0000-0002-4491-2613
authors.initials: G
authors.lastname: Parthan
authors.affiliation: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Nehru Hospital, 4th Floor, F Block, Chandigarh 160012, India.
authors.forename: Anuradha
authors.identifier: 0000-0003-2698-1823
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Department of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Nandita
authors.initials: N
authors.lastname: Kakkar
authors.affiliation: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Nehru Hospital, 4th Floor, F Block, Chandigarh 160012, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.affiliation: Department of Laboratory Medicine and Surgical Pathology, St. Michael's Hospital, Room 2-101V, 30 Bond Street, Toronto, ON, Canada M5B 1W8.
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.affiliation: Department of Laboratory Medicine and Surgical Pathology, St. Michael's Hospital, Room 2-101V, 30 Bond Street, Toronto, ON, Canada M5B 1W8.
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs