title: State of the art of mechanical circulatory support.
abstract: Mechanical circulatory support of the failing heart has become an important means of treating end-stage heart disease. This rapidly growing therapeutic field has produced impressive clinical outcomes and has great potential to help thousands of otherwise terminal patients worldwide. In this review, we examine the state of the art of mechanical circulatory support: current practice, totally implantable systems of the future, evolving biventricular support mechanisms, the potential for myocardial recovery and adjunctive treatment methods, and miniaturized devices with expanded indications for therapy.
authors.affiliation: Department of Surgery, Baylor College of Medicine; and Center for Cardiac Support, Texas Heart Institute; Houston, Texas 77030.
authors.forename: Hari R
authors.initials: HR
authors.lastname: Mallidi
authors.affiliation: Department of Surgery, Baylor College of Medicine; and Center for Cardiac Support, Texas Heart Institute; Houston, Texas 77030.
authors.forename: Jatin
authors.initials: J
authors.lastname: Anand
authors.affiliation: Department of Surgery, Baylor College of Medicine; and Center for Cardiac Support, Texas Heart Institute; Houston, Texas 77030.
authors.forename: William E
authors.initials: WE
authors.lastname: Cohn
mesh_terms: D001243:Assisted Circulation / Q000266:history / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design / Q000266:history*; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery; D016027:Heart Transplantation / Q000266:history / Q000379:methods; D006353:Heart-Assist Devices / Q000145:classification / Q000266:history; D049673:History, 20th Century; D006801:Humans; D062069:Inventions; D017063:Outcome Assessment, Health Care
keywords: Assisted circulation/instrumentation; device removal; equipment design; heart failure/therapy; heart-assist devices/trends/utilization; patient selection; recovery of function; treatment outcome; ventricular dysfunction, left/therapy; ventricular function/physiology