title: Paclitaxel and carboplatin treatment for advanced ovarian cancer during pregnancy.
abstract: Ovarian carcinoma during pregnancy is a rare event that should be treated. In these cases, due to the lack of information available, doubts about the safety of mother and fetus are present. In this report, a 42-year-old woman who was diagnosed with a stage III ovarian carcinoma received six cycles of chemotherapy with carboplatin and paclitaxel from the 16th until 36th week of gestation. At 38 weeks, a normal male baby was born. There were no abnormalities during birth and during a 2-month follow-up period. This case adds to the available literature and supports the use of these chemotherapy agents during pregnancy, if the risk-benefit balance is appropriate.
authors.affiliation: Pharmacy Department, HUP La Fe, Valencia, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Ruiz Ramos
authors.forename: Eva
authors.initials: E
authors.lastname: Roma
authors.forename: Laura
authors.initials: L
authors.lastname: Palomar
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Poveda
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D011256:Pregnancy Outcome
chemical_list: D016190:Carboplatin; D017239:Paclitaxel