title: BRAF inhibitor resistance can be overcome by blocking autophagy.
abstract: ER stress-induced autophagy confers resistance to BRAF inhibitors in BRAF-mutant melanoma.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001343:Autophagy / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm; D064593:Heterografts; D006801:Humans; D008545:Melanoma; D051379:Mice; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf