title: Oral cavity contains distinct niches with dynamic microbial communities.
abstract: Microbes colonize human oral surfaces within hours after delivery. During postnatal development, physiological changes, such as the eruption of primary teeth and replacement of the primary dentition with permanent dentition, greatly alter the microbial habitats, which, in return, may lead to community composition shifts at different phases in people's lives. By profiling saliva, supragingival and mucosal plaque samples from healthy volunteers at different ages and dentition stages, we observed that the oral cavity is a highly heterogeneous ecological system containing distinct niches with significantly different microbial communities. More importantly, the phylogenetic microbial structure varies with ageing. In addition, only a few taxa were present across the whole populations, indicating a core oral microbiome should be defined based on age and oral niches.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Jinzhi
authors.initials: J
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Keke
authors.initials: K
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.forename: Xianghong
authors.initials: X
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
authors.forename: Mingyun
authors.initials: M
authors.lastname: Li
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Shi
authors.forename: Xuedong
authors.initials: X
authors.lastname: Zhou
mesh_terms: D039903:Actinobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D015373:Bacterial Typing Techniques; D041963:Bacteroidetes / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D003773:Dental Plaque / Q000382:microbiology*; D005260:Female; D045182:Fusobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D054892:Metagenome; D064307:Microbiota / Q000235:genetics*; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D010802:Phylogeny; D020560:Proteobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012463:Saliva / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D013144:Spirochaetales / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D012336:RNA, Ribosomal, 16S