title: First trimester biomarkers in the prediction of later pregnancy complications.
abstract: Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophylactic therapies, institution of an appropriate model and location of care, and recruitment of a truly "high risk" population to clinical trials of interventions to prevent or ameliorate these conditions. To this end, development of adequately sensitive and specific predictive tests for these outcomes has become a significant focus of perinatal research. This paper reviews the biomarkers involved in these multiparametric tests and also outlines the performance of these tests and issues regarding their introduction into clinical practice.
authors.affiliation: Department of Perinatal Medicine, The Royal Women's Hospital, Cnr Grattan Street and Flemington Road, Parkville, VIC 3052, Australia.
authors.forename: Stefan C
authors.initials: SC
authors.lastname: Kane
authors.affiliation: Department of Perinatal Medicine, The Royal Women's Hospital, Cnr Grattan Street and Flemington Road, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, VIC 3010, Australia ; Monash Ultrasound for Women, 15 Murray Street, Clayton, VIC 3170, Australia.
authors.forename: Fabricio da Silva
authors.initials: Fda S
authors.lastname: Costa
authors.affiliation: Department of Perinatal Medicine, The Royal Women's Hospital, Cnr Grattan Street and Flemington Road, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Shaun
authors.identifier: 0000-0003-3070-6971
authors.initials: S
authors.lastname: Brennecke
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D011261:Pregnancy Trimester, First
chemical_list: D015415:Biomarkers