title: Hesperidin and rutin, antioxidant citrus flavonoids, attenuate cisplatin-induced nephrotoxicity in rats.
abstract: This study aimed to assess the protective effect of hesperidin (HES) and rutin (RUT) against cisplatin-induced nephrotoxicity in male rats. Cisplatin (5 mg/kg, intraperitoneal) caused significant increases in serum sodium, blood urea nitrogen, serum creatinine, total sodium and potassium excreted in urine, urine volume, and lipid peroxides measured as the malondialdehyde content of kidney, with significant decreases in serum total protein, creatinine clearance, reduced glutathione content of kidney, and kidney superoxide dismutase activity as compared with the control group. On the other hand, administration of HES (200 mg/kg, per oral [p.o.]) or RUT (30 mg/kg, p.o.) for 14 days with a single cisplatin dose on the tenth day ameliorated the cisplatin-induced nephrotoxicity as indicated by the restoration of kidney function and oxidative stress biomarkers. Furthermore, the test drugs reduced the histopathological changes induced by cisplatin. In conclusion, HES and RUT showed protective effects against cisplatin-induced nephrotoxicity.
authors.affiliation: Pharmacolgy Department, National Organization for Drug Control and Research, Egypt, Cairo. doctorkamelmohamed@gmail.com.
authors.forename: Kamel M
authors.initials: KM
authors.lastname: Kamel
authors.forename: Ola M
authors.initials: OM
authors.lastname: Abd El-Raouf
authors.forename: Salwa A
authors.initials: SA
authors.lastname: Metwally
authors.forename: Hekma A
authors.initials: HA
authors.lastname: Abd El-Latif
authors.forename: Mostafa E
authors.initials: ME
authors.lastname: El-sayed
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects*; D002957:Citrus / Q000737:chemistry*; D006569:Hesperidin / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D012431:Rutin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D012431:Rutin; D006569:Hesperidin; D002945:Cisplatin
keywords: Antioxidant; Cisplatin; Hesperidin; Nephrotoxicity; Rutin