title: Anti-dermatitis, anxiolytic and analgesic effects of Rhazya stricta from Balochistan.
abstract: Current study was carried out on Rhazya stricta. Plant material was collected from Jhalmagsi Dist. Balochistan, Pakistan. Methanolic extract of Rhazya stricta was tested for anti-dermatitis, analgesic, anxiolytic effects, insecticidal activity and Brine shrimp Bioassay. Crude extract showed significant anti-dermatitis activity, as the results of intensity score showed mild Excoriation or erosion, moderate Edema or populations and absence of Erythema or hemorrhage, Scratching time was decreased to 1.45 and histological observations of mice treated with crude extract showed mild changes and few inflammatory cells in several microscopic fields. The results of analgesic activity were significant and the percentage inhibition of writhes were 73.54% and 69.38% at 300mg/kg and 500mg/kg respectively. The overall response of crude extract in anxiolytic activities were depressive and crude extract showed sedative effects. In Brine shrimp (Artemsia salina) lethality bioassay crude extract showed dose depended significant activity, and showed positive lethality with LD(50) 3.3004μg/ml. Insecticidal activity was positive against Callosbruchus analis, the percent mortality was 40%.
authors.affiliation: Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi, Pakistan.
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacy, University of Balochistan, Quetta, Pakistan.
authors.forename: Shafi
authors.initials: S
authors.lastname: Muhammed
authors.affiliation: Department of Pharmacology, Federal Urdu University of Arts, Science & Technology, Karachi, Pakistan.
authors.lastname: Mehjabeen
authors.affiliation: Department of Pharmacology, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Noor
authors.initials: N
authors.lastname: Jahan
authors.affiliation: Department of Pharmacy, University of Balochistan, Quetta, Pakistan.
authors.forename: Syed Umer
authors.initials: SU
authors.lastname: Jan
authors.affiliation: Department of Pharmacology, Jinnah Medical and Dental Collage, Karachi, Pakistan.
authors.forename: Zia-Ul-Rehaman
authors.initials: ZU
authors.lastname: Qureshi
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D029062:Apocynaceae; D001156:Artemia / Q000187:drug effects; D003872:Dermatitis / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D010936:Plant Extracts