title: BNCT for advanced or recurrent head and neck cancer.
abstract: The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-squamous cell carcinoma without malignant melanoma (non-SCC) of the head and neck. Currently, clinical trials of BNCT for head and neck cancers are being conducted in some institutes to verify its the effectiveness. BNCT was performed in 10 patients with recurrent SCC, 7 patients with recurrent non-SCC and 3 patients with newly diagnosed non-SCC in our university between October 2003 and September 2007. Eleven patients showed complete remission and 7 patients showed partial remission of irradiated site. The effective rate [(CR+PR)/total cases] was 90%. No severe acute or chronic normal-tissue reactions were observed in any patients. BNCT is effective and safe in the patients with recurrent SCC and locally advanced non-SCC.
authors.affiliation: Proton Medical Research Centre, University of Tsukuba, Tsukuba, Japan; Departments of Otolaryngology Head and Neck Surgery, Japan. Electronic address: aiteru@med.email.ne.jp.
authors.forename: Teruhito
authors.initials: T
authors.lastname: Aihara
authors.affiliation: Departments of Otolaryngology Head and Neck Surgery, Japan.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Morita
authors.affiliation: Radiation Oncology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kamitani
authors.affiliation: Proton Medical Research Centre, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kumada
authors.affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.affiliation: Radiation Oncology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Hiratsuka
authors.affiliation: Departments of Otolaryngology Head and Neck Surgery, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Harada
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000009:adverse effects / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D018572:Disease-Free Survival; D019317:Evidence-Based Medicine; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D016896:Treatment Outcome
keywords: BNCT; Head and neck cancer; Locally advanced non-SCC; Recurrent SCC