title: Follicular thyroid carcinoma characterized by abundant stromal components with chondroid and osseous metaplasia in a dog.
abstract: A dog developed a cervical mass, and computed tomography verified a mass surrounding the trachea with some pulmonary masses. Histopathologically, the cervical mass was composed of malignant neoplastic cells showing follicular appearance which reacted positive for thyroglobulin on immunohistochemistry. A characteristic feature of the tumor was abundant and metaplastic stromal components. Anastomosed collagenous tissues connecting to capsule of the tumor were abundant in the stroma. In parts of the collagenous tissues, mature cartilages and bones were continuously formed. There was no cellular atypia or invasion in the components. We diagnosed this case as follicular thyroid carcinoma with metaplastic stroma. This is the first case report that characterizes stromal components with chondroid and osseous metaplasia in a canine thyroid carcinoma.
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitamori
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Kitamori
authors.forename: Kazunari
authors.initials: K
authors.lastname: Sato
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Wako
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D001842:Bone and Bones / Q000473:pathology*; D002356:Cartilage / Q000473:pathology*; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006652:Histological Techniques / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D008679:Metaplasia / Q000473:pathology / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary