title: Nickel-catalyzed cross-electrophile coupling of 2-chloropyridines with alkyl bromides.
abstract: The synthesis of 2-alkylated pyridines by the nickel-catalyzed cross-coupling of two different electrophiles, 2-chloropyridines with alkyl bromides, is described. Compared to our previously published conditions for aryl halides, this method uses the different, more rigid bathophenanthroline ligand and is conducted at high concentration in DMF solvent. The method displays promising functional group compatibility and the conditions are orthogonal to the Stille coupling.
authors.affiliation: Department of Chemistry, University of Rochester, Rochester, NY 14627-0216 USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Everson
authors.affiliation: Department of Chemistry, University of Rochester, Rochester, NY 14627-0216 USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Buonomo
authors.affiliation: Department of Chemistry, University of Rochester, Rochester, NY 14627-0216 USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weix
keywords: Nickel; catalysis; cross-coupling; electrophile; pyridine