title: Relationship between pretreatment FDG-PET and diffusion-weighted MRI biomarkers in diffuse large B-cell lymphoma.
abstract: The purpose of this study was to determine the correlation between the (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) standardized uptake value (SUV) and the diffusion-weighted magnetic resonance imaging (MRI) apparent diffusion coefficient (ADC) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). Pretreatment FDG-PET and diffusion-weighted MRI of 21 patients with histologically proven DLBCL were prospectively analyzed. In each patient, maximum, mean and peak standardized uptake value (SUV) was measured in the lesion with visually highest FDG uptake and in the largest lesion. Mean ADC (ADCmean, calculated with b-values of 0 and 1000 s/mm(2)) was measured in the same lesions. Correlations between FDG-PET metrics (SUVmax, SUVmean, SUVpeak) and ADCmean were assessed using Pearson's correlation coefficients. In the lesions with visually highest FDG uptake, no significant correlations were found between the SUVmax, SUVmean, SUVpeak and the ADCmean (P=0.498, P=0.609 and P=0.595, respectively). In the largest lesions, there were no significant correlations either between the SUVmax, SUVmean, SUVpeak and the ADCmean (P=0.992, P=0.843 and P=0.894, respectively). The results of this study indicate that the glycolytic rate as measured by FDG-PET and changes in water compartmentalization and water diffusion as measured by the ADC are independent biological phenomena in newly diagnosed DLBCL. Further studies are warranted to assess the complementary roles of these different imaging biomarkers in the evaluation and follow-up of DLBCL.
authors.affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, The Netherlands.
authors.forename: Antoinette
authors.initials: A
authors.lastname: de Jong
authors.affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, The Netherlands.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Kwee
authors.affiliation: Department of Nuclear Medicine, Meander Medical Center Amersfoort, The Netherlands.
authors.forename: John M H
authors.initials: JM
authors.lastname: de Klerk
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center Amsterdam, The Netherlands ; Department of Radiology, Academic Medical Center Amsterdam, The Netherlands.
authors.forename: Judit A
authors.initials: JA
authors.lastname: Adam
authors.affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, The Netherlands.
authors.forename: Bart
authors.initials: B
authors.lastname: de Keizer
authors.affiliation: Department of Hematology, Meander Medical Center Amersfoort, The Netherlands.
authors.forename: Rob
authors.initials: R
authors.lastname: Fijnheer
authors.affiliation: Department of Hematology, Academic Medical Center Amsterdam, The Netherlands.
authors.forename: Marie José
authors.initials: MJ
authors.lastname: Kersten
authors.affiliation: Department of Hematology, University Medical Center Utrecht Utrecht, The Netherlands.
authors.forename: Inge
authors.initials: I
authors.lastname: Ludwig
authors.affiliation: Department of Hematology, VU University Medical Center Amsterdam, The Netherlands.
authors.forename: Yvonne W S
authors.initials: YW
authors.lastname: Jauw
authors.affiliation: Department of Hematology, VU University Medical Center Amsterdam, The Netherlands.
authors.forename: Josée M
authors.initials: JM
authors.lastname: Zijlstra
authors.affiliation: Department of Radiology, VU University Medical Center Amsterdam, The Netherlands.
authors.forename: Indra C
authors.initials: IC
authors.lastname: Pieters-Van den Bos
authors.affiliation: Department of Radiology, Academic Medical Center Amsterdam, The Netherlands.
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center Amsterdam The Netherlands.
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
authors.affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, The Netherlands.
authors.forename: Rutger A J
authors.initials: RA
authors.lastname: Nievelstein
keywords: FDG-PET; apparent diffusion coefficient; diffuse large B-cell lymphoma; diffusion-weighted MRI; standardized uptake value