title: New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria.
abstract: A series consisting of ianthelliformisamimes A, B, and C as well as its synthetic analogues was prepared in high chemical yield, from 27 to 91%, using peptide coupling as the key step, and the compounds were evaluated for their in vitro antibiotic enhancer properties against resistant Gram-negative bacteria and clinical isolates. The mechanism of action of one of these derivatives against Pseudomonas aeruginosa when combined with doxycycline was precisely evaluated utilizing bioluminescence to measure ATP efflux and fluorescence to evaluate membrane depolarization.
authors.affiliation: Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258, Institut Paoli Calmettes, Aix-Marseille Université , UM 105, Inserm, U1068, F-13009 Marseille, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Pieri
authors.forename: Diane
authors.initials: D
authors.lastname: Borselli
authors.forename: Carole
authors.initials: C
authors.lastname: Di Giorgio
authors.forename: Michel
authors.initials: M
authors.lastname: De Méo
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bolla
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vidal
authors.forename: Sébastien
authors.initials: S
authors.lastname: Combes
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Brunel
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; C574286:ianthelliformisamine A; C574287:ianthelliformisamine B; C574288:ianthelliformisamine C; D014443:Tyrosine