title: Elevated intraocular pressure in patients with acromegaly.
abstract: OBJECTIVE
  To evaluate central corneal thickness (CCT) and intraocular pressure (IOP) in a cohort of acromegalic patients, and to correlate CCT with serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).
  
  
  METHODS
  Consecutive patients affected by acromegaly underwent a comprehensive endocrinological and ophthalmological evaluation, including serum GH and IGF-1 levels, CCT measured with ultrasonic pachymetry and IOP assessed with Goldmann applanation tonometry.
  
  
  RESULTS
  Fourteen patients with acromegaly and 28 healthy controls were included in the study. Acromegalic patients had a statistically higher median CCT (570 μm [range 551.5-638] vs 542.7 μm [range 461.5-610]; p < 0.01) and higher median IOP (17.2 mm Hg [range 14-21] vs 13.7 mm Hg [range 10.5-19]; p < 0.01) than healthy controls. No statistically significant correlation was found among CCT and GH, CCT and IGF-1, IOP and GH, IOP and IGF-1 in the acromegalic group, whereas a statistically significant correlation was documented between CCT and IOP in the entire cohort (Spearman's correlation coefficient: 0.56, p < 0.01). However, when IOP was corrected for CCT no significant difference was found between the two study groups (p = 0.07).
  
  
  CONCLUSIONS
  Our results suggest that acromegaly is associated with an increased CCT, which could lead to an overestimation of IOP readings as determined with Goldmann applanation tonometry.
authors.affiliation: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy, luciano.quaranta@unibs.it.
authors.forename: Luciano
authors.initials: L
authors.lastname: Quaranta
authors.forename: Ivano
authors.initials: I
authors.lastname: Riva
authors.forename: Gherardo
authors.initials: G
authors.lastname: Mazziotti
authors.forename: Teresa
authors.initials: T
authors.lastname: Porcelli
authors.forename: Irene
authors.initials: I
authors.lastname: Floriani
authors.forename: Andreas
authors.initials: A
authors.lastname: Katsanos
authors.forename: Andrea
authors.initials: A
authors.lastname: Giustina
authors.forename: Anastasios G P
authors.initials: AG
authors.lastname: Konstas
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003315:Cornea / Q000473:pathology*; D063171:Corneal Pachymetry; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D014065:Tonometry, Ocular
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone