title: Highly water-soluble, porous, and biocompatible boron nitrides for anticancer drug delivery.
abstract: Developing materials for "Nano-vehicles" with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS) , Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Qunhong
authors.initials: Q
authors.lastname: Weng
authors.forename: Binju
authors.initials: B
authors.lastname: Wang
authors.forename: Xuebin
authors.initials: X
authors.lastname: Wang
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hanagata
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Dequan
authors.initials: D
authors.lastname: Liu
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Xiangfen
authors.initials: X
authors.lastname: Jiang
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Bando
authors.forename: Dmitri
authors.initials: D
authors.lastname: Golberg
mesh_terms: D000327:Adsorption; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D006801:Humans; D006900:Hydroxylation; D051379:Mice; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*; D016062:Porosity; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D001896:Boron Compounds; D004337:Drug Carriers; D014867:Water; C017282:boron nitride; D004317:Doxorubicin