title: Synthesis and radiolabeling of (111)In-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging.
abstract: The objective of this study was the development of a dual-modality imaging device, namely (111)In-core-cross-linked polymeric micelle (CCPM)-octreotide, for neuroendocrine tumor detection, using near-infrared fluoroscopy (NIRF) and single photon emission computed tomography (SPECT). The tumor targeting ability of the (111)In-labeled CCPM-octreotide was evaluated in a tumor mouse model. SPECT/CT, NIRF and gamma imaging results showed high tumor uptake of (111)In-labeled CCPM-octreotide. In contrast, there was a much lower signal in the same mouse model injected with (111)In-labeled CCPM. The high accumulation of (111)In-labeled CCPM-octreotide in U87 tumor was reduced after co-injection with an excess amount of CCPM-octreotide. These results suggested CCPM-octreotide's potential applications in tumor diagnosis, drug delivery and molecular imaging.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, PR China; Isotope Department, China Institute of Atomic Energy, Beijing 102413, PR China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Isotope Department, China Institute of Atomic Energy, Beijing 102413, PR China.
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, PR China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Lin
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Experimental Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, PR China. Electronic address: pekyz@163.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003952:Diagnostic Imaging; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D005471:Fluoroscopy; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D015282:Octreotide / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003432:Cross-Linking Reagents; D008823:Micelles; D011108:Polymers; D019275:Radiopharmaceuticals; D015282:Octreotide
keywords: Dual-modality imaging; Near-infrared fluoroscopy; Octreotide; Single photon emission computed tomography; Tumor detection