title: Characteristics and outcomes of transposition of great arteries in the neonatal period.
abstract: OBJECTIVE
  Transposition of the great arteries is a prevalent congenital heart defect with a high survival rate and a good long-term outcome, especially if managed with early surgical intervention during the neonatal period. In this study, our main objective was to describe patient characteristics and outcomes and to identify possible predictors of early and long-term morbidity and mortality.
  
  
  METHODS
  Retrospective analysis through review of clinical and surgical charts of patients with transposition of the great arteries admitted to the service of neonatology during 2000-2011.
  
  
  RESULTS
  The study included 136 patients; 119 of them had undergone corrective surgery during the neonatal period. Patients were divided into 3 groups: group I, 81 cases of isolated transposition; group II, 24 cases with ventricular septal defect; and group III, 31 with "complex" transposition of the great arteries. The overall postoperative survival was 96.7% (115 of 119 patients); no patients from group I died after surgery. Duration of surgery, intubation, inotropic treatment, and length of stay were higher in patients in groups II and III. The overall survival rate after an average of 6 years of follow-up was 90.4% 123 of 136 patients, with no deaths after discharge in group I. The most frequent residual defect during cardiac follow-up was supravalvular pulmonary stenosis, in 33 of 113 patients that had follow-up data.
  
  
  CONCLUSIONS
  In our study, the survival rate was high in patients with transposition of great arteries and especially in those undergoing arterial switch. The number of subsequent residual heart defects was low.
authors.affiliation: Servicio de Neonatología, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Turon-Viñas
authors.affiliation: Servicio de Neonatología, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. Electronic address: ariverola@hsjdbcn.org.
authors.forename: Ana
authors.initials: A
authors.lastname: Riverola-de Veciana
authors.affiliation: Servicio de Neonatología, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Moreno-Hernando
authors.affiliation: Servicio de Cardiología Pediátrica, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Bartrons-Casas
authors.affiliation: Servicio de Cardiología Pediátrica, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Fredy H
authors.initials: FH
authors.lastname: Prada-Martínez
authors.affiliation: Servicio de Cirugía Cardiovascular, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Mayol-Gómez
authors.affiliation: Servicio de Cirugía Cardiovascular, Unitat Integrada Hospital Clínic-Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Caffarena-Calvar
mesh_terms: D002316:Cardiotonic Agents / Q000627:therapeutic use; D013504:Cardiovascular Surgical Procedures; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D061646:Operative Time; D012189:Retrospective Studies; D014188:Transposition of Great Vessels / Q000401:mortality* / Q000601:surgery*
chemical_list: D002316:Cardiotonic Agents
keywords: Arterial switch operation; Cardiopatía congénita; Cirugía cardiaca neonatal; Congenital heart disease; Neonatal cardiac surgery; Switch arterial; Transposición de grandes vasos; Transposition of the great arteries