title: Iterative breakthrough invasive aspergillosis due to TR(34) /L98H azole-resistant Aspergillus fumigatus and Emericella sublata in a single hematopoietic stem cell transplant patient.
abstract: We report 3 consecutive episodes of invasive aspergillosis in a single hematopoietic stem cell transplant patient successively attributed to TR(34) /L98H azole-resistant Aspergillus fumigatus and to a first occurrence of invasive Emericella sublata infection. This case illustrates potential selection of resistant molds during antifungal therapy in hematological patient.
authors.affiliation: Service d'Hématologie-Greffe de Moelle, Groupe hospitalier Lariboisière-Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France; Sorbonne Paris Cité, Université Paris Diderot, Paris, France.
authors.forename: F S
authors.initials: FS
authors.lastname: de Fontbrune
authors.forename: B
authors.initials: B
authors.lastname: Denis
authors.forename: M
authors.initials: M
authors.lastname: Meunier
authors.forename: D
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.forename: S
authors.initials: S
authors.lastname: Bretagne
authors.forename: A
authors.initials: A
authors.lastname: Alanio
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001393:Azoles / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics; D025141:Drug Resistance, Fungal; D032842:Emericella / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D005656:Fungal Proteins / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D011401:Promoter Regions, Genetic
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D004271:DNA, Fungal; D005656:Fungal Proteins; D003577:Cytochrome P-450 Enzyme System; C465526:cytochrome P-450 CYP51A, Aspergillus
keywords: Aspergillus fumigatus; Emericella sublata; azole resistance; breakthrough infection; invasive aspergillosis