title: Novel water-based antiseptic lotion demonstrates rapid, broad-spectrum kill compared with alcohol antiseptic.
abstract: A novel alcohol-based antiseptic and a novel water-based antiseptic lotion, both with a synergistic combination of antimicrobial ingredients containing 0.2% benzethonium chloride, were evaluated using the standard time-kill method against 25 FDA-specified challenge microorganisms. The purpose of the testing was to determine whether a non-alcohol product could have equivalent rapid and broad-spectrum kill to a traditional alcohol sanitizer. Both the alcohol- and water-based products showed rapid and broad-spectrum antimicrobial activity. The average 15-s kill was 99.999% of the challenge organism for the alcohol-based antiseptic and 99.971% for the water-based antiseptic. The alcohol-based product demonstrated 100% of peak efficacy (60s) within the first 15s, whereas the water-based product showed 99.97%. The novel alcohol-based antiseptic reduced concentrations of 100% of organisms by 99.999%, whereas the water-based antiseptic lotion showed the same reduction for 96% of organisms. A novel water-based antiseptic product demonstrated equivalent rapid, broad-spectrum antimicrobial activity to an alcohol-based sanitizer and provided additional benefits of reduced irritation, persistent effect, and greater efficacy against common viruses. The combination of rapid, broad-spectrum immediate kill and persistent efficacy against pathogens may have significant clinical benefit in limiting the spread of disease.
authors.affiliation: Innovative BioDefense, Inc., 21581 Midcrest Drive, Lake Forest, CA 92630, United States. Electronic address: mrczman@aol.com.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Czerwinski
authors.affiliation: Innovative BioDefense, Inc., 21581 Midcrest Drive, Lake Forest, CA 92630, United States.
authors.forename: Jesse
authors.initials: J
authors.lastname: Cozean
authors.affiliation: Innovative BioDefense, Inc., 21581 Midcrest Drive, Lake Forest, CA 92630, United States.
authors.forename: Colette
authors.initials: C
authors.lastname: Cozean
mesh_terms: D000438:Alcohols; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D018407:Bacterial Physiological Phenomena / Q000187:drug effects; D005658:Fungi / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects; D012997:Solvents; D013997:Time Factors; D014867:Water
chemical_list: D000438:Alcohols; D000891:Anti-Infective Agents, Local; D012997:Solvents; D014867:Water
keywords: Benzethonium chloride; Broad-spectrum antimicrobial activity; Hand sanitizer; Persistence