title: [Rapid detection of extrinsic harmful contaminants using quantum dots-coated probes and their application prospects in traditional Chinese medicine].
abstract: The contamination of extrinsic harmful contaminants including mycotoxins, heavy metals and pesticides, etc, brings serious risks to traditional Chinese medicines (TCMs), further to human health. Due to their unique photoluminescence, chemiluminescence, electrochemical and electrochemiluminescence properties, semiconductor quantum dots (QDs) nanoparticles are widely used to immobilize bioprobes and biosensors, etc. In this review, the luminescence characteristics and specific ligands of QDs probles which are used to determine contaminants were summed up. Then, the applications of QDs-coated novel probes in the determination of mycotoxins, heavy metals and pesticides were discussed in detail. In addition, the contamination levels and characteristics of extrinsic harmful residues in TCMs were investigated. Further, the maximum levels of those contaminants in TCMs were compared with those set by various countries. Finally, the future development trends and problems of QDs-coated probes in the determination of those extrinsic residues in TCMs were prospected.
authors.forename: Xi-Hui
authors.initials: XH
authors.lastname: Yang
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Kong
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ouyang
mesh_terms: D004340:Drug Contamination / Q000517:prevention & control; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D045663:Quantum Dots; D012449:Safety; D013997:Time Factors