title: The health risk of chrysotile asbestos.
abstract: OBJECTIVE
  The word asbestos is a poorly attributed term, as it refers to two very different minerals with very different characteristics. One is the serpentine mineral of which the white asbestos, chrysotile, is the most common. The other is the amphibole asbestos, which includes the blue asbestos crocidolite and the brown asbestos amosite. Although today chrysotile is the only type used commercially, the legacy of past use of amphibole asbestos remains. This review clarifies the differences between the two mineral families referred to as asbestos and summarizes the scientific basis for understanding the important differences in the toxicology and epidemiology of these two minerals.
  
  
  RESULTS
  Biopersistence and sub-chronic inhalation toxicology studies have shown that exposure to chrysotile at up to 5000 times the current threshold limit value (0.1 fibers/cm) produces no pathological response. These studies demonstrate as well that following short-term exposure the longer chrysotile fibers rapidly clear from the lung and are not observed in the pleural cavity. In contrast, short-term exposure to amphibole asbestos results quickly in the initiation of a pathological response in the lung and the pleural cavity.
  
  
  CONCLUSIONS
  Significant progress has been made in understanding the factors that influence inhalation toxicology studies of fibers and epidemiological studies of workers. Evaluation of the toxicology and epidemiology studies of chrysotile indicates that it can be used safely under controlled use. In contrast, even short-term exposure to amphibole asbestos can result in disease.
authors.affiliation: Consultant in Toxicology, Geneva, Switzerland.
authors.forename: David M
authors.initials: DM
authors.lastname: Bernstein
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity*; D017636:Asbestos, Amphibole / Q000032:analysis / Q000633:toxicity*; D017632:Asbestos, Serpentine / Q000032:analysis / Q000633:toxicity*; D001195:Asbestosis / Q000473:pathology*; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000473:pathology*; D019016:Mineral Fibers / Q000009:adverse effects; D009784:Occupational Diseases / Q000139:chemically induced / Q000473:pathology*; D012306:Risk
chemical_list: D000395:Air Pollutants, Occupational; D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine; D019016:Mineral Fibers