title: Recurrent thymoma with stiff-person syndrome and pure red blood cell aplasia.
abstract: Stiff-person syndrome (formerly known as stiff-man syndrome) is a very rare autoimmune and neurogenic disorder, thought to present as a paraneoplastic variant in association with thymoma. Pure red blood cell aplasia is also a paraneoplastic disorder associated with thymoma. Although separate cases of stiff-person syndrome and pure red blood cell aplasia have been reported, we describe here what is to our knowledge the first case of recurrent thymoma with both stiff-person syndrome and pure red blood cell aplasia. We describe the successful treatment of the neurogenic symptoms of stiff-person syndrome and the progressive anemia associated with pure red blood cell aplasia by tumor excision.
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan. Electronic address: chinosenar@gmail.com.
authors.forename: Rei
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kaji
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Horiuchi
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Miyahara
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Hino
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suemasu
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000601:surgery*; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D012086:Reoperation / Q000379:methods; D018570:Risk Assessment; D016750:Stiff-Person Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013934:Thymectomy / Q000379:methods; D013945:Thymoma / Q000175:diagnosis / Q000601:surgery*; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome