title: Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation.
abstract: Ceftazidime is a broad spectrum third generation cephalosporin antibiotic which is effective mainly against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter and Enterobacteriaceae, the pathogens which most often cause ophthalmological infections. Unlike other commonly used beta lactam antibiotics, ceftazidime is resistant to several types of beta lactamases (e.g., TEM, SHV and PSE-1). Because of these advantages, ceftazidime is used in the treatment of eye infections. However, ceftazidime undergoes rapid degradation in aqueous solutions therefore eye drops containing ceftazidime in aqueous solutions are not commercially manufactured. In the present study, liposomal encapsulations of ceftazidime with various lipid compositions, hydrating solutions and pH-values have been studied in order to optimize liposomal composition for a potential eye drop formulation.
authors.affiliation: Department of Chemistry, Sam Houston State University, Huntsville, TX, 77341, USA.
authors.forename: Chamari
authors.initials: C
authors.lastname: Wijesooriya
authors.affiliation: Department of Chemistry, Sam Houston State University, Huntsville, TX, 77341, USA ; Department of Pharmaceutics, Semmelweis University, Hőgyes E. u. 7, Budapest, H-1092, Hungary.
authors.forename: Marianna
authors.initials: M
authors.lastname: Budai
authors.affiliation: Department of Pharmaceutics, Semmelweis University, Hőgyes E. u. 7, Budapest, H-1092, Hungary.
authors.forename: Lívia
authors.initials: L
authors.lastname: Budai
authors.affiliation: Department of Pulmonology, University Clinic Salzburg, Müllner Hauptstraβe 48, Salzburg, A-5020, Austria.
authors.forename: Magdolna E
authors.initials: ME
authors.lastname: Szilasi
authors.affiliation: Department of Chemistry, Sam Houston State University, Huntsville, TX, 77341, USA.
authors.forename: Ilona
authors.initials: I
authors.lastname: Petrikovics
keywords: Ceftazidime; encapsulation; liposome; ophthalmology