title: A rapid entry to amino acid derived diverse 3,4-dihydropyrazines and dihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition.
abstract: An efficient, general and practical synthesis of diverse 3,4-dihydropyrazines, 6,7-dihydro-[1,2,3]triazolopyrazines and 7,8-dihydro-[1,2,3]triazolodiazepines through intramolecular 1,3-dipolar cycloaddition from amino acid derived common intermediates with high yields is described. Moreover, one-pot access to optically active 3-aryl substituted 6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazines in the palladium-copper co-catalytic system has also been achieved in this work. The easy substrate availability and operational simplicity make the process suitable for further exploration.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, B.S. 10/1, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India. gautam.panda@gmail.com gautam_panda@cdri.res.in.
authors.forename: Saurav
authors.initials: S
authors.lastname: Bera
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D010165:Palladium / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010879:Piperazines; D011719:Pyrazines; D014230:Triazoles; D010165:Palladium; D003300:Copper