title: Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2',4,4'-tetrabromodiphenyl ether.
abstract: Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 μg/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 μg/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology.
authors.affiliation: Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS); Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai 264003, PR China; The University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Ji
authors.affiliation: Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS); Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai 264003, PR China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS); Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai 264003, PR China. Electronic address: hfwu@yic.ac.cn.
authors.forename: Huifeng
authors.initials: H
authors.lastname: Wu
mesh_terms: D000818:Animals; D005260:Female; D005411:Flame Retardants / Q000633:toxicity*; D006066:Gonads / Q000187:drug effects* / Q000378:metabolism; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D008297:Male; D055432:Metabolomics; D049878:Mytilus / Q000187:drug effects* / Q000378:metabolism; D012737:Sex Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D014874:Water Pollutants, Chemical; C511295:2,2',4,4'-tetrabromodiphenyl ether
keywords: BDE 47; Metabolomics; Mytilus galloprovincialis; NMR; Toxicological effects