title: Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
abstract: CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. CD157 (-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157 (-/-) mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Lopatina
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yoshihara
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nishimura
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Shirin
authors.initials: S
authors.lastname: Akther
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Azam A K M
authors.initials: AA
authors.lastname: Fakhrul
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Mingkun
authors.initials: M
authors.lastname: Liang
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Higashida
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Sumi
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Furuhara
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inahata
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Jian-Jung
authors.initials: JJ
authors.lastname: Huang
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Koizumi
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yokoyama
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Petugina
authors.affiliation: Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
authors.forename: Andrei
authors.initials: A
authors.lastname: Sumarokov
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
authors.forename: Alla B
authors.initials: AB
authors.lastname: Salmina
authors.affiliation: Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences Kanazawa, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hashida
authors.affiliation: Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences Kanazawa, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kitao
authors.affiliation: Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences Kanazawa, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Hori
authors.affiliation: Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Asano
authors.affiliation: Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Kitamura
authors.affiliation: Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kozaka
authors.affiliation: Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shiba
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhong
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan.
authors.forename: Min-Jue
authors.initials: MJ
authors.lastname: Xie
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan ; Research Center for Child Mental Development, University of Fukui Fukui, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Immunology and Molecular Genetics, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ishihara
authors.affiliation: Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
keywords: BST-1; emotion-related behavior; non-motor symptoms; oxytocin; social behavior