title: Interplay of cell proliferation and cell death in Drosophila tissue regeneration.
abstract: Regeneration is a fascinating process that allows some organisms to reconstruct damaged tissues. In addition to the classical regeneration model of the Drosophila larval imaginal discs, the genetically induced tissue ablation model has promoted the understanding of molecular mechanisms underlying cell death, proliferation, and remodeling for tissue regeneration. Recent studies have also revealed that tissue injury responses occur not only locally but also systemically, even in the uninjured region. Genetic studies in Drosophila have demonstrated the dynamic role of the cell death-induced tissue response in the reconstruction of damaged tissues.
authors.affiliation: Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033.
authors.forename: Soshiro
authors.initials: S
authors.lastname: Kashio
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Obata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miura
mesh_terms: D000818:Animals; D016923:Cell Death; D049109:Cell Proliferation; D004330:Drosophila / Q000166:cytology* / Q000196:embryology / Q000378:metabolism*; D060227:Imaginal Discs / Q000166:cytology / Q000378:metabolism; D023421:Models, Animal; D014945:Wound Healing
keywords: Drosophila; cell death; compensatory proliferation; imaginal disc; regeneration