title: [Stromal exosomes allow cancer cell autoactivation].
abstract: Exosomes are small vesicles derived from endosomes and carrying several constituants of the cell; if captured by other neighbour cell types, they can trigger novel functions in these cells. We illustrate here (through recently published results) how exosomes released by activated tumor-associated fibroblasts are able to induce in cancer cells a signalling pathway key to the acquisition of motility and hence metastatic property.
authors.affiliation: Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5 Toronto, Ontario, Canada.
authors.forename: Frédéric A
authors.initials: FA
authors.lastname: Fellouse
mesh_terms: D000818:Animals; D055354:Exosomes; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D017154:Stromal Cells