title: Induced pluripotent stem cells in hematology: current and future applications.
abstract: Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.
authors.affiliation: Division of Transfusion Medicine and Transplant Biology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Focosi
authors.affiliation: 1] Harvard Medical School, Boston, MA, USA [2] Harvard Stem Cell Institute, Boston, MA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Amabile
authors.affiliation: 1] Harvard Medical School, Boston, MA, USA [2] Harvard Stem Cell Institute, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Di Ruscio
authors.affiliation: Retrovirus Centre and Virology Section, Department of Translational Research, University of Pisa, Pisa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Quaranta
authors.affiliation: 1] Harvard Medical School, Boston, MA, USA [2] Cancer Science Institute, National University of Singapore, Singapore, Singapore.
authors.forename: D G
authors.initials: DG
authors.lastname: Tenen
authors.affiliation: Retrovirus Centre and Virology Section, Department of Translational Research, University of Pisa, Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pistello
mesh_terms: D000818:Animals; D006405:Hematology / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*