title: Effects of taurolidine and chlorhexidine on SaOS-2 cells and human gingival fibroblasts grown on implant surfaces.
abstract: OBJECTIVE
  The purpose of the study was the evaluation of possible cytologic effects of taurolidine to fibroblasts and osteoblast-like cells.
  
  
  METHODS
  Human gingival fibroblasts and SaOS-2 cells were seeded on samples with sand-blasted and acid-etched surfaces. Both groups were treated with taurolidine, chlorhexidine, and pure water with three different treatment times. Three dates of measurements were set to evaluate cell viability, cytotoxicity, and apoptosis.
  
  
  RESULTS
  Highest cytotoxicity was measured in both cell lines in the groups treated with chlorhexidine, while cell viability was lower than in the corresponding taurolidine and pure water groups; on days 3 and 6 these differences were significant. Taurolidine showed similar results to the pure water groups.
  
  
  CONCLUSIONS
  The results of this study indicate that taurolidine is biocompatible and gentle to the tested human cells for the application time of a mouthrinse.
authors.forename: Gordon
authors.initials: G
authors.lastname: John
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor / Q000166:cytology / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002710:Chlorhexidine / Q000494:pharmacology*; D015921:Dental Implants; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005881:Gingiva / Q000166:cytology*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013829:Thiadiazines / Q000494:pharmacology*
chemical_list: D015921:Dental Implants; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine; D002710:Chlorhexidine