title: Electrochemical switching with 3D DNA tetrahedral nanostructures self-assembled at gold electrodes.
abstract: Nanomechanical switching of functional three-dimensional (3D) DNA nanostructures is crucial for nanobiotechnological applications such as nanorobotics or self-regulating sensor and actuator devices. Here, DNA tetrahedral nanostructures self-assembled onto gold electrodes were shown to undergo the electronically addressable nanoswitching due to their mechanical reconfiguration upon external chemical stimuli. That enables construction of robust surface-tethered electronic nanodevices based on 3D DNA tetrahedra. One edge of the tetrahedron contained a partially self-complementary region with a stem-loop hairpin structure, reconfigurable upon hybridization to a complementary DNA (stimulus DNA) sequence. A non-intercalative ferrocene (Fc) redox label was attached to the reconfigurable tetrahedron edge in such a way that reconfiguration of this edge changed the distance between the electrode and Fc.
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Science and Technology, ‡Center for DNA Nanotechnology (CDNA) at iNANO, and §Sino-Danish Centre for Education and Research (SDC) at iNANO, Aarhus University , Gustav Wieds Vej 1590-14, DK-8000 Aarhus C, Denmark.
authors.forename: Alireza
authors.initials: A
authors.lastname: Abi
authors.forename: Meihua
authors.initials: M
authors.lastname: Lin
authors.forename: Hao
authors.initials: H
authors.lastname: Pei
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.forename: Elena E
authors.initials: EE
authors.lastname: Ferapontova
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zuo
mesh_terms: D004247:DNA / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D049329:Nanostructures
chemical_list: D006046:Gold; D004247:DNA