title: Akt-ing up on SRPK1: oncogene or tumor suppressor?
abstract: In this issue of Molecular Cell, Wang et al. (2014) report that the splicing kinase SRPK1 can function as both an oncogene and a tumor suppressor by modulating the activation state of the protein kinase Akt. This is shown to be mediated by the ability of SRPK1 to bind to the Akt phosphatase PHLPP1.
authors.affiliation: Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: atoker@bidmc.harvard.edu.
authors.forename: Alex
authors.initials: A
authors.lastname: Toker
authors.affiliation: Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: rchin1@bidmc.harvard.edu.
authors.forename: Y Rebecca
authors.initials: YR
authors.lastname: Chin
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D009687:Nuclear Proteins; C490215:Srpk1 protein, mouse; D017346:Protein Serine-Threonine Kinases; C519282:PHLPP1 protein, mouse; D010749:Phosphoprotein Phosphatases