title: Primary splenic angiosarcoma associated with anemia, leukocytosis and thrombocytopenia.
abstract: Primary angiosarcoma of the spleen is a rare neoplasm arising from endothelial cells. It is an aggressive neoplasm with a poor prognosis. We report a case of 61-year-old Caucasian man who presented with shortness of breath, anemia, leukocytosis, and thrombocytopenia. Ultrasound Sonogram (US) and Computed Tomography (CT) scans revealed a massively enlarged spleen with numerous enhancing hypodense lesions. The spleen was adherent to the omentum, retroperitoneum, and tail of the pancreas. Image-guided Fine Needle Aspiration (FNA) revealed an atypical spindle cell lesion. Resection of the spleen and attached tail of pancreas was performed. Histological examination and immunohistochemical studies revealed a diffuse vascular malignant neoplasm with features of angiosarcoma. The patient appeared disease free after resection. He died within 5 months of unknown etiology.
authors.affiliation: MD; Department of Pathology, Michael E. DeBakey VA Medical Center, 2002 Holcombe Blvd, Houston, TX, 77030, USA; phone: 713 794 7246; fax: 713 794 7657; slai@bcm.tmc.edu.
authors.forename: Barina
authors.initials: B
authors.lastname: Aqil
authors.forename: Linda K
authors.initials: LK
authors.lastname: Green
authors.forename: Syeling
authors.initials: S
authors.lastname: Lai
mesh_terms: D000740:Anemia / Q000150:complications*; D017809:Fatal Outcome; D006394:Hemangiosarcoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D007964:Leukocytosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011860:Radiography, Abdominal; D013160:Splenic Neoplasms / Q000150:complications* / Q000473:pathology; D013921:Thrombocytopenia / Q000150:complications*; D014057:Tomography, X-Ray Computed