title: Radiation-induced osteosarcoma of the hand: case report.
abstract: Radiation-associated sarcomas represent less than 5% of all sarcomas and can arise from previously irradiated bone or soft tissue. We report a case of radiation-associated osteosarcoma that developed in the hand of a patient who had previously been treated for synovial sarcoma. Despite aggressive, multimodality treatment, the disease progressed rapidly. This case highlights the need for patients and treating physicians to be aware of this potential complication of radiotherapy to the hand.
authors.affiliation: Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI. Electronic address: mark_e_puhaindran@nuhs.edu.sg.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Puhaindran
authors.affiliation: Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI.
authors.forename: Kendall
authors.initials: K
authors.lastname: Hamilton
authors.affiliation: Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI.
authors.forename: Stacy
authors.initials: S
authors.lastname: Schlumbohm
authors.affiliation: Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI.
authors.forename: Maria
authors.initials: M
authors.lastname: Rich
authors.affiliation: Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI.
authors.forename: Deanna
authors.initials: D
authors.lastname: Mitchell
authors.affiliation: Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI.
authors.forename: Matthew
authors.initials: M
authors.lastname: Steensma
mesh_terms: D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006225:Hand; D006801:Humans; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000628:therapy; D012516:Osteosarcoma / Q000209:etiology*; D016879:Salvage Therapy; D013584:Sarcoma, Synovial / Q000532:radiotherapy; D055815:Young Adult
keywords: Radiation; hand; osteosarcoma; sarcoma