title: Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system.
abstract: Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer.
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Ge
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: zhoujiahong@njnu.edu.cn.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing 210029, PR China. Electronic address: huijun_jiang2006@hotmail.com.
authors.forename: Huijun
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers and Institutes Fudan University, Shanghai 200433, PR China.
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001692:Biological Transport; D002166:Camptothecin / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D000077146:Irinotecan; D010087:Oxides / Q000737:chemistry*; D010569:Perylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D019800:Phenol; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010087:Oxides; D017319:Photosensitizing Agents; D011809:Quinones; D026082:Singlet Oxygen; D019800:Phenol; D010569:Perylene; D000077146:Irinotecan; D006108:Graphite; C048388:hypocrellin A; D002166:Camptothecin
keywords: 7-Ethyl-10-hydroxycamptothecin; Combination therapy; Graphene oxide; Hypocrellin A