title: The prevalence of adverse events associated with double-balloon enteroscopy from a single-centre dataset in Japan.
abstract: BACKGROUND
  There are few comprehensive reports detailing the prevalence of major adverse events associated with a double-balloon enteroscopy procedure.
  
  
  METHODS
  We retrospectively investigated the prevalence of major adverse events in 538 patients (262 males and 276 females; median age, 65 years; age range, 12-95 years) who underwent double-balloon enteroscopy at our Institution between April 2008 and October 2011.
  
  
  RESULTS
  Of the 17 adverse events recorded (3.2%), acute pancreatitis (n=5; 0.9%) occurred during both diagnostic (n=3) and therapeutic (n=2) anterograde double-balloon enteroscopy, and all of them were treated conservatively. For these cases, the average duration of the examination was 135 min, which was longer than for the other patients (97 min) (P=0.046). Intestinal bleeding (1.3%) was observed in 6 cases after endoscopic polypectomy and in 1 case following a biopsy procedure during a diagnostic double-balloon enteroscopy. The prevalence rates of intestinal perforation and other complications were 0.2% and 0.7%, respectively.
  
  
  CONCLUSIONS
  The rate of adverse events associated with double-balloon enteroscopy was high compared to that associated with conventional upper/lower gastrointestinal endoscopy (0.042%/0.078%). The occurrence of acute pancreatitis may be significantly dependent on the duration of double-balloon enteroscopy examination.
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Sayoko
authors.initials: S
authors.lastname: Nakayama
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan. Electronic address: tomy@med.osaka-cu.ac.jp.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tominaga
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Obayashi
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Okamoto
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Minamino
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ominami
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Shusei
authors.initials: S
authors.lastname: Fukunaga
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Nagami
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sugimori
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Machida
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Okazaki
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Mitsue
authors.initials: M
authors.lastname: Sogawa
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Yamagami
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanigawa
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Arakawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000009:adverse effects; D002648:Child; D058582:Double-Balloon Enteroscopy / Q000009:adverse effects*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007416:Intestinal Perforation / Q000453:epidemiology* / Q000209:etiology; D007417:Intestinal Polyps / Q000601:surgery; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
keywords: Adverse events; Bleeding; Endoscopy; Pancreatitis; Small intestine