title: Managing coeliac disease in patients with diabetes.
abstract: The association between coeliac disease and type 1 diabetes has long been established. The combination of genetic susceptibility along with a potential role for gluten in the pathogenesis of autoimmunity makes defining gluten's role in type 1 diabetes extremely important. Evidence supporting the role of a gluten-free diet to improve complications associated with type 1 diabetes is not robust. However there is evidence to support improved growth, bone density and potentially the prevention of additional autoimmune diseases in patients with coeliac disease and type 1 diabetes. The gluten free diet is expensive and challenging to adhere to in people already on a modified diet. Early identification of those who have coeliac disease and would benefit from a gluten-free diet is of utmost importance to prevent complications associated with type 1 diabetes and coeliac disease.
authors.affiliation: Center for Celiac Research, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Leonard
authors.forename: P A
authors.initials: PA
authors.lastname: Cureton
authors.forename: A
authors.initials: A
authors.lastname: Fasano
mesh_terms: D000818:Animals; D015551:Autoimmunity; D002446:Celiac Disease / Q000150:complications / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology; D048909:Diabetes Complications / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000178:diet therapy* / Q000276:immunology; D003927:Diet, Diabetic / Q000009:adverse effects; D055050:Diet, Gluten-Free / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006801:Humans; D010349:Patient Compliance; D012720:Severity of Illness Index
keywords: coeliac disease; gluten-free diet; type 1 diabetes