title: The dual role of HLA-G in cancer.
abstract: We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies. For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been proposed to counteract it. Aside from these numerous studies on solid tumors, recent data showed that HLA-G inhibits the proliferation of malignant B cells due to the interaction between HLA-G and its receptor ILT2, which mediates negative signaling on B cell proliferation. These results led to the conjecture that, according to the malignant cell type, HLA-G should be blocked or conversely induced to counteract tumor progression. In this context, we will here present (i) the dual role of HLA-G in solid and liquid tumors with special emphasis on (ii) the HLA-G active structures and their related ILT2 and ILT4 receptors and (iii) the current knowledge on regulatory mechanisms of HLA-G expression in tumors.
authors.affiliation: CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, France ; Université Paris Diderot, Sorbonne Paris Cité, IUH, Hopital Saint-Louis, UMR_E5, 75010 Paris, France.
authors.forename: Nathalie
authors.identifier: 0000-0001-5288-0191
authors.initials: N
authors.lastname: Rouas-Freiss
authors.affiliation: CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, France ; Université Paris Diderot, Sorbonne Paris Cité, IUH, Hopital Saint-Louis, UMR_E5, 75010 Paris, France.
authors.forename: Philippe
authors.identifier: 0000-0002-2868-7401
authors.initials: P
authors.lastname: Moreau
authors.affiliation: CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, France ; Université Paris Diderot, Sorbonne Paris Cité, IUH, Hopital Saint-Louis, UMR_E5, 75010 Paris, France.
authors.forename: Joel
authors.initials: J
authors.lastname: LeMaoult
authors.affiliation: CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, France ; Université Paris Diderot, Sorbonne Paris Cité, IUH, Hopital Saint-Louis, UMR_E5, 75010 Paris, France.
authors.forename: Edgardo D
authors.initials: ED
authors.lastname: Carosella
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism
chemical_list: D059951:HLA-G Antigens; D011971:Receptors, Immunologic