title: Identification and quantitation of the ingredients in a counterfeit Vietnamese herbal medicine against rheumatic diseases.
abstract: Counterfeit and/or illegally manufactured drugs and herbal medicines are becoming an increasing problem throughout the world. Internet sales simplify distribution and payment of these falsified drugs. Here we report on a Vietnamese herbal medicine, which was advertised for treatment of rheumatic disease from a religious Vietnamese healer. By means of NMR and LC/MS we found 863mg acetaminophen, 262mg sulfamethoxazole, 42mg indomethacin and less than 1% trimethoprim in a sachet of 2.617g powder content, in addition to some cinnamon bark and phosphate.
authors.affiliation: Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Wuerzburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Wiest
authors.affiliation: Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Wuerzburg, Germany.
authors.forename: Curd
authors.initials: C
authors.lastname: Schollmayer
authors.affiliation: Pharmaceutical Biology, Julius-von-Sachs-Institute for Biosciences, University of Wuerzburg, Wuerzburg, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Gresser
authors.affiliation: Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Wuerzburg, Germany. Electronic address: u.holzgrabe@pharmazie.uni-wuerzburg.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Holzgrabe
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D002853:Chromatography, Liquid; D002935:Cinnamomum zeylanicum; D058110:Counterfeit Drugs / Q000737:chemistry*; D029001:Herbal Medicine; D007213:Indomethacin / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010710:Phosphates / Q000032:analysis*; D024301:Plant Bark; D012216:Rheumatic Diseases / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000032:analysis*; D014295:Trimethoprim / Q000032:analysis*; D014744:Vietnam
chemical_list: D058110:Counterfeit Drugs; D010710:Phosphates; D000082:Acetaminophen; D014295:Trimethoprim; D013420:Sulfamethoxazole; D007213:Indomethacin
keywords: Antirheumatic herbal medicine; IR; Illegal drug; LC/MS; NMR