title: Understanding the colloidal stability of the mesoporous MIL-100(Fe) nanoparticles in physiological media.
abstract: The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron(III) trimesate MIL-100(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100(Fe) nanoparticles exhibit an appropriate colloidal stability and biodegradability, mainly dependent on both the nature of their physicochemical surface and the media composition, being a priori compatible with their biomedical use.
authors.affiliation: Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines , 45 avenue des Etats-Unis, 78035 Versailles cedex, France.
authors.forename: Elena
authors.initials: E
authors.lastname: Bellido
authors.forename: Mazheva
authors.initials: M
authors.lastname: Guillevic
authors.forename: Tania
authors.initials: T
authors.lastname: Hidalgo
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Santander-Ortega
authors.forename: Christian
authors.initials: C
authors.lastname: Serre
authors.forename: Patricia
authors.initials: P
authors.lastname: Horcajada
mesh_terms: D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D007501:Iron / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D014233:Tricarboxylic Acids / Q000737:chemistry*
chemical_list: D003102:Colloids; D004337:Drug Carriers; D014233:Tricarboxylic Acids; D007501:Iron; C069849:trimesic acid