title: Dendritic cells in autoimmune disorders and cancer of the thyroid.
abstract: Dendritic cells (DCs), considered as one of the crucial immune regulatory populations, are implicated in the immune pathology of various disorders. Also in the thyroid gland, DCs were shown to be involved in early and chronic phases of various types of autoimmunity - including Hashimoto's thyroiditis and Graves' disease. In thyroid malignant processes, DCs are suggested as an important element of both tumour defence and tumour immune evasion mechanisms. Recent findings emphasize a crucial role of interactions between particular DC subsets and other regulatory cell populations (e.g. FoxP3+ regulatory T cells) in thyroid pathology. Additionally, an increasing attention has been paid to the control of DC function by thyrometabolic conditions.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital, Lodz, Poland. alewin@csk.umed.lodz.pl.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lewinski
authors.forename: Przemyslaw Wiktor
authors.initials: PW
authors.lastname: Sliwka
authors.forename: Mariusz
authors.initials: M
authors.lastname: Stasiolek
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000473:pathology* / Q000502:physiology*; D006111:Graves Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D013961:Thyroid Gland / Q000166:cytology / Q000276:immunology; D013964:Thyroid Neoplasms / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000276:immunology* / Q000473:pathology