title: A new triterpenoid saponin and an oligosaccharide isolated from the fruits of Sapindus mukorossi.
abstract: A new triterpenoid saponin (1) and a new oligosaccharide (2), together with three known saponins (3-5), have been isolated from n-BuOH extract of the fruits of Sapindus mukorossi Gaertn. The structures were elucidated using detailed analysis of one- and two-dimensional nuclear magnetic resonance spectra along with their mass spectrometric data and the results of acid hydrolysis. Of the isolated compounds 1 and 3-5 displayed cytotoxic effects against human cancer cell lines in A-549 (lung carcinoma), MDA-231 (breast carcinoma) and PC-3 (prostatic carcinoma).
authors.affiliation: a School of Pharmaceutical Sciences, Sun Yat-sen University , 132 Waihuan Rd East, Panyu, Guangzhou 510006 , P.R. China.
authors.forename: Xuan-Ming
authors.initials: XM
authors.lastname: Zhang
authors.forename: De-Po
authors.initials: DP
authors.lastname: Yang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Xie
authors.forename: Xue
authors.initials: X
authors.lastname: Xue
authors.forename: Long-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032127:Sapindus / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D009844:Oligosaccharides; D012503:Saponins; D014315:Triterpenes; C000592819:alpha-L-rhamnopyranosyl-(1-3)-(alpha-L-rhamnopyranosyl-(1-2))-beta-D-glucopyranosyl-(1-1)-beta-D-glucopyranosyl-((2-1)-alpha-L-rhamnopyranosyl)-(3-1)-alpha-L-rhamnopyranose; C000592818:hederagenin-3-O-beta-D-glucopyranosyl-(1-3)-beta-D-xylopyranosyl-(1-3)-beta-D-xylopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-2)-alpha-L-arabinopyranoside; D009828:Oleanolic Acid
keywords: Sapindus mukorossi; cytotoxicity; oligosaccharide; triterpene saponin