title: Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report.
abstract: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).
authors.affiliation: Department of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Holdener
authors.affiliation: Department of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.
authors.forename: Lacey
authors.initials: L
authors.lastname: Harrington
authors.affiliation: Department of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.
authors.forename: Johnny
authors.initials: J
authors.lastname: Nguyen
authors.affiliation: Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Horna
authors.affiliation: Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sagatys
authors.affiliation: Department of Hematological Malignancies, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.
authors.forename: Bijal
authors.initials: B
authors.lastname: Shah
authors.affiliation: Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000150:complications; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology* / Q000235:genetics*; D035602:Transcriptional Elongation Factors; D014178:Translocation, Genetic / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; C497422:KMT2A protein, human; D009687:Nuclear Proteins; D035602:Transcriptional Elongation Factors; D019938:Cyclin D1; D051788:Myeloid-Lymphoid Leukemia Protein; C081449:AFF1 protein, human; D011495:Histone-Lysine N-Methyltransferase
keywords: Mantle; lymphoma; therapy; transformation; variant