title: Simultaneous magnetic resonance imaging and consolidation measurement of articular cartilage.
abstract: Magnetic resonance imaging (MRI) offers the opportunity to study biological tissues and processes in a non-disruptive manner. The technique shows promise for the study of the load-bearing performance (consolidation) of articular cartilage and changes in articular cartilage accompanying osteoarthritis. Consolidation of articular cartilage involves the recording of two transient characteristics: the change over time of strain and the hydrostatic excess pore pressure (HEPP). MRI study of cartilage consolidation under mechanical load is limited by difficulties in measuring the HEPP in the presence of the strong magnetic fields associated with the MRI technique. Here we describe the use of MRI to image and characterize bovine articular cartilage deforming under load in an MRI compatible consolidometer while monitoring pressure with a Fabry-Perot interferometer-based fiber-optic pressure transducer.
authors.affiliation: Discipline of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology/2 George St., Brisbane 4001, Australia. m.wellard@qut.edu.au.
authors.forename: Robert Mark
authors.initials: RM
authors.lastname: Wellard
authors.affiliation: SonoSite France Sarl, 19, avenue de Norvege, Parc d'activite les Fjords, Immeuble le Vega, 91140 Villebon sur Yvette, France. jp.ravasio@free.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ravasio
authors.affiliation: National Instruments France, 2 rue Hennape, 92735 Nanterre Cédex, France. samuelguesne@hotmail.fr.
authors.forename: Samuel
authors.initials: S
authors.lastname: Guesne
authors.affiliation: Discipline of Biomedical Engineering and Medical Physics, Queensland University of Technology/2 George St., Brisbane 4001, Australia. Christopher.Bell@csiro.au.
authors.forename: Christopher
authors.initials: C
authors.lastname: Bell
authors.affiliation: Discipline of Biomedical Engineering and Medical Physics, Queensland University of Technology/2 George St., Brisbane 4001, Australia. k.oloyede@qut.edu.au.
authors.forename: Adekunle
authors.initials: A
authors.lastname: Oloyede
authors.affiliation: Science and Engineering Faculty, Queensland University of Technology/2 George St., Brisbane 4001, Australia. gregtev@gmail.com.
authors.forename: Greg
authors.initials: G
authors.lastname: Tevelen
authors.affiliation: Discipline of Biomedical Engineering and Medical Physics, Queensland University of Technology/2 George St., Brisbane 4001, Australia. j.pope@qut.edu.au.
authors.forename: James M
authors.initials: JM
authors.lastname: Pope
authors.affiliation: Discipline of Biomedical Engineering and Medical Physics, Queensland University of Technology/2 George St., Brisbane 4001, Australia. k.momot@qut.edu.au.
authors.forename: Konstantin I
authors.initials: KI
authors.lastname: Momot
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000033:anatomy & histology* / Q000502:physiology*; D002417:Cattle; D019245:Compressive Strength / Q000502:physiology; D055119:Elastic Modulus / Q000502:physiology; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D006874:Hydrostatic Pressure; D066298:In Vitro Techniques; D007368:Interferometry / Q000295:instrumentation* / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014160:Transducers, Pressure; D014783:Viscosity; D016474:Weight-Bearing / Q000502:physiology*