title: Interleukin-27 mediates inflammation during chronic disease.
abstract: The interleukin (IL)-12 family cytokine, IL-27 has been implicated in the pathogenesis of many autoimmune inflammatory disorders, including rheumatoid arthritis, psoriasis, multiple sclerosis, Crohn's disease, and ulcerative colitis. Discovered in 2002, IL-27 has been primarily described as an anti-inflammatory cytokine with regulatory roles in multiple sclerosis and experimental autoimmune encephalitis. However, recent studies have demonstrated a pro-inflammatory function of IL-27 in both the adaptive and innate immune responses. This review will focus on the proinflammatory nature of IL-27 in chronic inflammatory skin disease and inflammatory bowel disease.
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University , Kingston, Canada .
authors.forename: Christopher
authors.initials: C
authors.lastname: Wynick
authors.forename: Carlene
authors.initials: C
authors.lastname: Petes
authors.forename: Katrina
authors.initials: K
authors.lastname: Gee
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity; D002908:Chronic Disease; D003872:Dermatitis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D064094:Interleukin-27 / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D064094:Interleukin-27