title: Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency.
abstract: It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.
authors.affiliation: Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University Department of Pediatrics, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Endo
authors.affiliation: Department of Virology, Tokyo Medical and Dental University.
authors.forename: Ken
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Division of Molecular Genetics, Fujita Health University, Toyoake.
authors.forename: Tamae
authors.initials: T
authors.lastname: Ohye
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Matsubara
authors.affiliation: Department of Virology, Tokyo Medical and Dental University.
authors.forename: Norio
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Division of Molecular Genetics, Fujita Health University, Toyoake.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurahashi
authors.affiliation: Department of Pediatrics, Fujita Health University, Toyoake.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Department of Pathology.
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
authors.affiliation: Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
authors.affiliation: Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University.
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Imai
authors.affiliation: Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takagi
authors.affiliation: Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.affiliation: Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University.
authors.forename: Shuki
authors.initials: S
authors.lastname: Mizutani
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002892:Chromosomes, Human, Pair 22 / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005347:Fibroblasts / Q000821:virology; D015654:Herpesvirus 6, Human / Q000302:isolation & purification* / Q000502:physiology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007963:Leukocytes, Mononuclear / Q000821:virology; D008297:Male; D008853:Microscopy; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000821:virology*; D014775:Virus Activation; D053632:X-Linked Combined Immunodeficiency Diseases / Q000150:complications*
chemical_list: D004279:DNA, Viral
keywords: HHV-6; X-SCID; ciHHV-6; hemophagocytic syndrome; thrombotic microangiopathy