title: Unraveling architecture of the pluripotent genome.
abstract: Genomes are folded into sophisticated configurations that both shape, and are shaped by, a diverse range of nuclear functions. High-throughput variations of Chromosome-Conformation-Capture-based technologies now enable analysis of architecture at unprecedented resolution and scale. Here I discuss the complex structure-function relationship of the mammalian genome using the model system of embryonic stem cells, and the progression from pluripotency to terminal differentiation and back again.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19103, USA. Electronic address: jcremins@seas.upenn.edu.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Phillips-Cremins
mesh_terms: D000818:Animals; D019070:Cell Lineage; D002875:Chromosomes / Q000235:genetics; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors