title: A highly sensitive nucleic acid stain based on amino-modified tetraphenylethene: the influence of configuration.
abstract: We designed and synthesized a new amino-functionalized tetraphenylethene (TPE) derivative as a highly sensitive dye for the detection of dsDNA and oligonucleotide in both solution and a gel matrix. We further revealed that the cis configuration dye showed a much higher sensitivity than its trans isomer for the first time.
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan, 430072, People's Republic of China. clyang@whu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Zece
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Jingui
authors.initials: J
authors.lastname: Qin
authors.forename: Chuluo
authors.initials: C
authors.lastname: Yang
mesh_terms: D004247:DNA / Q000032:analysis*; D005030:Ethylenes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D007536:Isomerism; D009841:Oligonucleotides / Q000032:analysis*; D012996:Solutions / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D005030:Ethylenes; D005456:Fluorescent Dyes; D005782:Gels; D009841:Oligonucleotides; D012996:Solutions; D004247:DNA