title: Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: another example of developmental hemostasis?
abstract: Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P = 0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.
authors.affiliation: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Varnell
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Goldstein
authors.forename: Donald L
authors.initials: DL
authors.lastname: Yee
authors.forename: Jun
authors.initials: J
authors.lastname: Teruya
authors.forename: Kirk E
authors.initials: KE
authors.lastname: Guyer
authors.forename: Shakeel
authors.initials: S
authors.lastname: Siddiqui
authors.forename: John L
authors.initials: JL
authors.lastname: Jefferies
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006487:Hemostasis; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000652:urine
chemical_list: D013929:Thromboxane B2; C049235:11-dehydro-thromboxane B2
keywords: aspirin; children; neonates; pediatric; thromboxane