title: How pervasive are circadian oscillations?
abstract: Circadian oscillations play a critical role in coordinating the physiology, homeostasis, and behavior of biological systems. Once thought to only be controlled by a master clock, recent high-throughput experiments suggest many genes and metabolites in a cell are potentially capable of circadian oscillations. Each cell can reprogram itself and select a relatively small fraction of this broad repertoire for circadian oscillations, as a result of genetic, environmental, and even diet changes.
authors.affiliation: Department of Computer Science, University of California - Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Patel
authors.affiliation: Department of Biological Chemistry, University of California - Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, CA 92697, USA.
authors.forename: K
authors.initials: K
authors.lastname: Eckel-Mahan
authors.affiliation: Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California - Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, CA 92697, USA.
authors.forename: P
authors.initials: P
authors.lastname: Sassone-Corsi
authors.affiliation: Department of Computer Science, University of California - Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California - Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, CA 92697, USA. Electronic address: pfbaldi@ics.uci.edu.
authors.forename: P
authors.initials: P
authors.lastname: Baldi
mesh_terms: D000818:Animals; D001683:Biological Clocks; D002940:Circadian Rhythm; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D055442:Metabolome
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins
keywords: circadian metabolome; circadian rhythms; circadian transcriptome; clock; coupled oscillators; oscillatory patterns