title: MiR-718 represses VEGF and inhibits ovarian cancer cell progression.
abstract: Oncogenic activation of VEGF is found in various malignancies, including ovarian cancer. In this study, we investigate the role of microRNA (miRNA) in the regulation of VEGF in ovarian cancer. We find that miR-718 is expressed at low levels and inversely correlates with VEGF expression in ovarian cancer specimens. MiR-718 also directly targets and represses VEGF expression. In addition, miR-718 restoration inhibits ovarian cancer proliferation both in vitro and in vivo. Moreover, VEGF expression could reverse the effect of miR-718 on ovarian cancer by increasing the levels of phosphorylated AKT. These results suggest a new therapeutic strategy in ovarian cancer by restoring miR-718 expression, which is involved in VEGF regulation.
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, People's Republic of China.
authors.forename: Ruobing
authors.initials: R
authors.lastname: Leng
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, People's Republic of China.
authors.forename: Lang
authors.initials: L
authors.lastname: Zha
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, People's Republic of China. Electronic address: tangleng2012@126.com.
authors.forename: Liangdan
authors.initials: L
authors.lastname: Tang
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D055785:Gene Knockdown Techniques; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology*; D034741:RNA, Small Interfering / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000172:deficiency* / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; C000589574:MIRN718 microRNA, human; D035683:MicroRNAs; D034741:RNA, Small Interfering; D042461:Vascular Endothelial Growth Factor A
keywords: Apoptosis; MiR-718; Ovarian cancer; Proliferation; VEGF