title: Interneurons scratch an itch.
abstract: Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
authors.affiliation: Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Postgraduate Program in Cellular and Molecular Biology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil.
authors.forename: Paula Juliana Seadi
authors.initials: PJ
authors.lastname: Pereira
authors.affiliation: Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: elerner@partners.org.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Lerner
mesh_terms: D000818:Animals; D004399:Dynorphins / Q000378:metabolism*; D007395:Interneurons / Q000378:metabolism*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D020671:Posterior Horn Cells / Q000378:metabolism*; D011537:Pruritus / Q000378:metabolism* / Q000517:prevention & control*
chemical_list: D004399:Dynorphins