title: Application of iPS cell-derived macrophages to cancer therapy.
abstract: We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection of iPS-MCs expressing interferon β significantly inhibited the growth of human gastric and pancreatic cancers implanted in the peritoneal cavity of immunocompromised mice.
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Senju
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Koba
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Haruta
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Matsunaga
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsumura
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Haga
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Tokunori
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Takamatsu
authors.affiliation: Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nishimura
keywords: gastric cancer; iPS cells; interferon β; macrophages; pancreatic cancer; peritoneal dissemination