title: Association between higher expression of YB-1 and poor prognosis in early-stage extranodal nasal-type natural killer/T-cell lymphoma.
abstract: OBJECTIVE
  A recent study shows that YB-1-related biomarkers affect the prognosis of patients with natural killer/T-cell lymphoma (NKTCL). The aim of this study was to determine whether there is an association between YB-1 expression and the prognosis of patients with early-stage extranodal nasal-type NKTCL.
  
  
  METHODS
  To clarify the roles of YB-1 in early-stage extranodal nasal-type NKTCL, we used immunohistochemical studies to examine YB-1 expression in 36 early-stage extranodal nasal-type NKTCL specimens.
  
  
  RESULTS
  Subsequently, YB-1 expression was correlated with clinicopathologic parameters. Higher expression of YB-1 was associated with an increased potential for relapse, poor disease-free survival and reduced overall survival.
  
  
  CONCLUSIONS
  Higher expression of YB-1 could be an independent risk factor for poor prognosis in patients with early-stage extranodal nasal-type NKTCL. Understanding the biology of YB-1-mediated pathways may lead to novel therapeutic strategies for early-stage extranodal nasal-type NKTCL.
authors.affiliation: Department of Oncology, Mian Yang Central Hospital, Sichuan, People's Republic of China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhao
authors.forename: Yao
authors.initials: Y
authors.lastname: Liao
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Jingbo
authors.initials: J
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Bangxian
authors.initials: B
authors.lastname: Tan
authors.forename: Surong
authors.initials: S
authors.lastname: Reng
authors.forename: Zhikui
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xioaodong
authors.initials: X
authors.lastname: Feng
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Du
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D019002:CD56 Antigen / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D051840:Y-Box-Binding Protein 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D019002:CD56 Antigen; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human