title: Altering the intratumoral localization of macrophages to inhibit cancer progression.
abstract: Hypoxia confers to macrophages angiogenic and immunosuppressive properties which promote tumor growth and progression. Preventing the migration of macrophages into hypoxic tumor regions hinders angiogenesis and restores the tumor-suppressive properties of these immune cells. We have recently uncovered a neuropilin 1- and semaphorin 3A-dependent signaling pathway that defines the repositioning of macrophages to hypoxic tumor niches, a discovery that generates new options for the development of complementary anticancer treatments.
authors.affiliation: Laboratory of Molecular Oncology and Angiogenesis; Vesalius Research Center; VIB; Leuven, Belgium ; Laboratory of Molecular Oncology and Angiogenesis; Vesalius Research Center; Department of Oncology; K.U. Leuven; Leuven, Belgium.
authors.forename: Andrea
authors.initials: A
authors.lastname: Casazza
authors.affiliation: Laboratory of Molecular Oncology and Angiogenesis; Vesalius Research Center; VIB; Leuven, Belgium ; Laboratory of Molecular Oncology and Angiogenesis; Vesalius Research Center; Department of Oncology; K.U. Leuven; Leuven, Belgium.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mazzone
keywords: angiogenesis; hypoxia; immunity; neuropilin; semaphorin; tumor-associated macrophages