title: Maximal oxygen uptake is associated with allele -202 A of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism and (CA)n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland.
abstract: Physical fitness is a trait determined by multiple genes, and its genetic basis is modified by numerous environmental factors. The present study examines the effects of the (CA)n tandem repeats polymorphism in IGFI gene and SNP Alw21I restriction site -202 A>C polymorphism in IGF1BP3 on VO2max--a physiological index of aerobic capacity of high heritability. The study sample consisted of 239 (154 male and 85 female) students of the University School of Physical Education in Poznań and athletes practicing various sports, including members of the Polish national team. An association was found between -202 A/C polymorphism of IGFBP3 gene with VO2max in men. Higher VO2max values were attained by men with CC genotype, especially male athletes practicing endurance sports and sports featuring energy metabolism of aerobic/anaerobic character. A statistically significant influence of allele 188 and genotype 188/188 of tandem repeats (CA)n polymorphism of IGF1 gene on VO2max was found in women. Also, lower values of maximal oxygen uptake were noted in individuals with allele 186 or genotype 186/186, and higher VO2max values in athletes with allele 194.
authors.affiliation: Department of Physiology, Faculty of Physical Education, Sport and Rehabilitation, The Eugeniusz Piasecki University School of Physical Education, Poznań, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Gronek
authors.affiliation: Department of Physiology, Faculty of Physical Education, Sport and Rehabilitation, The Eugeniusz Piasecki University School of Physical Education, Poznań, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Holdys
authors.affiliation: Department of Physiology, Faculty of Physical Education, Sport and Rehabilitation, The Eugeniusz Piasecki University School of Physical Education, Poznań, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Kryściak
authors.affiliation: Department of Anthropology and Biometrics, Faculty of Physical Education, Sport and Rehabilitation, The Eugeniusz Piasecki University School of Physical Education, Poznań, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wieliński
authors.affiliation: Department of Anthropology and Biometrics, Faculty of Physical Education, Sport and Rehabilitation, The Eugeniusz Piasecki University School of Physical Education, Poznań, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Słomski
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D056352:Athletes; D005260:Female; D005838:Genotype; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D018598:Minisatellite Repeats; D010807:Physical Endurance / Q000235:genetics*; D010809:Physical Fitness; D011044:Poland; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012737:Sex Factors; D014109:Total Lung Capacity / Q000235:genetics*; D044465:White People
chemical_list: C583557:IGF1 protein, human; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I