title: [18F]fluorodeoxyglucose positron emission tomography predicts survival after chemoimmunotherapy for primary mediastinal large B-cell lymphoma: results of the International Extranodal Lymphoma Study Group IELSG-26 Study.
abstract: OBJECTIVE
  To assess the role of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) after rituximab and anthracycline-containing chemoimmunotherapy in patients with primary mediastinal large B-cell lymphoma (PMLBCL).
  
  
  METHODS
  Among 125 patients prospectively enrolled, 115 were eligible for central review of PET/CT scans at the completion of standard chemoimmunotherapy, by using a five-point scale. Consolidation radiotherapy (RT) was permitted and given to 102 patients.
  
  
  RESULTS
  Fifty-four patients (47%) achieved a complete metabolic response (CMR), defined as a completely negative scan or with residual [18F]FDG activity below the mediastinal blood pool (MBP) uptake. In the remaining 61 patients (53%), the residual uptake was higher than MBP uptake but below the liver uptake in 27 (23%), slightly higher than the liver uptake in 24 (21%), and markedly higher in 10 (9%). CMR after chemoimmunotherapy predicted higher 5-year progression-free survival (PFS; 98% v 82%; P=.0044) and overall survival (OS; 100% v 91%; P=.0298). Patients with residual uptake higher than MBP uptake but below liver uptake had equally good outcomes without any recurrence. Using the liver uptake as cutoff for PET positivity (boundary of score, 3 to 4) discriminated most effectively between high or low risk of failure, with 5-year PFS of 99% versus 68% (P<.001) and 5-year OS of 100% versus 83% (P<.001).
  
  
  CONCLUSIONS
  More than 90% of patients are projected to be alive and progression-free at 5 years, despite a low CMR rate (47%) after chemoimmunotherapy. This study provides a basis for using PET/CT to define the role of RT in PMLBCL.
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Martelli
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Luca
authors.initials: L
authors.lastname: Ceriani
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain. ielsg@ticino.com.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Zinzani
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Andrés J M
authors.initials: AJ
authors.lastname: Ferreri
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Umberto
authors.initials: U
authors.lastname: Vitolo
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Caterina
authors.initials: C
authors.lastname: Stelitano
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Ercole
authors.initials: E
authors.lastname: Brusamolino
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Cabras
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Luigi
authors.initials: L
authors.lastname: Rigacci
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Balzarotti
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Flavia
authors.initials: F
authors.lastname: Salvi
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Montoto
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Armando
authors.initials: A
authors.lastname: Lopez-Guillermo
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Erica
authors.initials: E
authors.lastname: Finolezzi
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Pileri
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Andrew
authors.initials: A
authors.lastname: Davies
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Franco
authors.initials: F
authors.lastname: Cavalli
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Luca
authors.initials: L
authors.lastname: Giovanella
authors.affiliation: Maurizio Martelli and Erica Finolezzi, Sapienza University, Rome; Pier Luigi Zinzani and Stefano A. Pileri, Policlinico S. Orsola-Malpighi, Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milan; Umberto Vitolo, Azienda Ospedaliera S. Giovanni Battista, Torino; Caterina Stelitano, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria; Ercole Brusamolino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; Maria Giuseppina Cabras, Ospedale Businco, Cagliari; Luigi Rigacci, Policlinico Careggi, Florence; Monica Balzarotti, IRCCS Humanitas, Rozzano; Flavia Salvi, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Luca Ceriani, Emanuele Zucca, Franco Cavalli, and Luca Giovanella, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; Silvia Montoto, Barts Cancer Institute, London; Andrew Davies and Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom; and Armando Lopez-Guillermo, Hospital Clinic, Barcelona, Spain.
authors.forename: Peter W M
authors.initials: PW
authors.lastname: Johnson
mesh_terms: D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage; D064847:Multimodal Imaging / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D019275:Radiopharmaceuticals; D000069283:Rituximab; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D001761:Bleomycin; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate