title: Prognosis of patients with carcinoid heart disease after valvular surgery.
abstract: A best evidence topic in cardiac surgery was written according to a structured protocol. We addressed the following question: in patients who are diagnosed with carcinoid heart disease (CHD), do valvular surgeries improve their prognosis? Fifty percent of the patients with clinically diagnosed carcinoid syndrome had cardiac involvement which was present either as valvular dysfunction or as cardiac metastases. These patients often require surgery due to their heightened risk of cardiac disease. Altogether 217 relevant papers were identified as a result of the below-mentioned search, of which 10 papers represented the best evidence to answer the question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses were tabulated. Of the patients who were identified to have carcinoid heart disease in different studies, 193 patients had valve procedure, mainly replacements at tricuspid, mitral and aortic valve positions and either valvuloplasty or replacement at pulmonary valve. Tricuspid and pulmonary valves represented the majority of the excised valves among patients undergoing valvular surgery for CHD. The pathology of carcinoid valve was attributed to the presence of plaque, causing thickening and retraction. Pure regurgitation was the most common finding in all the valves except pulmonary valve which had both stenosis and insufficiency. Thirty-day mortality was 17% (range 1-63%) and long-term survivors were reported to be alive at an average of 58 months (28-80 months) after the valve surgery. The evidence demonstrates that surgical intervention can lead to improved prognosis and reduce the symptoms of heart failure. Postoperative mortality was mainly due to the carcinoid disease itself and not as a complication of the surgery. Therefore, surgery could be considered for symptomatic palliation in carefully selected individuals.
authors.affiliation: Manchester Heart Centre, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK imthiazmanoly@gmail.com.
authors.forename: Imthiaz
authors.initials: I
authors.lastname: Manoly
authors.affiliation: Manchester Heart Centre, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK.
authors.forename: Sarah-Louise
authors.initials: SL
authors.lastname: McAnelly
authors.affiliation: Manchester Heart Centre, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK.
authors.forename: Sanjeevan
authors.initials: S
authors.lastname: Sriskandarajah
authors.affiliation: Manchester Heart Centre, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK.
authors.forename: Kenneth Edward
authors.initials: KE
authors.lastname: McLaughlin
mesh_terms: D063126:Balloon Valvuloplasty; D019985:Benchmarking; D002275:Carcinoid Heart Disease / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D019317:Evidence-Based Medicine; D005260:Female; D006349:Heart Valve Diseases / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality; D006351:Heart Valves / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D018579:Patient Selection; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Carcinoid syndrome; Valve surgery; Valvular disease