title: In situ electroactive and antioxidant supramolecular hydrogel based on cyclodextrin/copolymer inclusion for tissue engineering repair.
abstract: The injectable electroactive and antioxidant hydrogels are prepared from mixing the tetraaniline functional copolymers and α-cyclodextrin (α-CD) aqueous solution. UV-vis and CV of the copolymer solution showed good electroactive properties. The antioxidant ability of the copolymer is also proved. The gelation mechanism and properties of the system are studied by WAXD, DSC, and rheometer. The encapsulated cells are highly viable in the hydrogels, suggesting that the hydrogels have excellent cytocompatibility. After subcutaneous injection, H&E staining study suggests acceptable biocompatibility of the materials in vivo. Moreover, data shows the injectable electroactive material can effectively accelerate the proliferation of encapsulated cells with electrical stimuli, and the mechanism is also elaborated. Such an injectable electroactive hydrogel would more closely mimic the native extracellular matrix, thereby combining a biomimetic environment of long-term cell survival and electrical signal to support the generation of functional tissue.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Cui
authors.forename: Liguo
authors.initials: L
authors.lastname: Cui
authors.forename: Peibiao
authors.initials: P
authors.lastname: Zhang
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001672:Biocompatible Materials; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D018914:Cells, Immobilized / Q000166:cytology / Q000187:drug effects; D004558:Electric Stimulation; D004560:Electricity; D020100:Hydrogels / Q000138:chemical synthesis* / Q000494:pharmacology; D007279:Injections, Subcutaneous; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects; D010851:Picrates / Q000037:antagonists & inhibitors; D058105:Polymerization; D051381:Rats; D017207:Rats, Sprague-Dawley; D023822:Tissue Engineering; D014867:Water; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D000975:Antioxidants; D001672:Biocompatible Materials; D001713:Biphenyl Compounds; D020100:Hydrogels; D010851:Picrates; D047391:alpha-Cyclodextrins; D014867:Water; C004931:1,1-diphenyl-2-picrylhydrazyl; C032613:alpha-cyclodextrin
keywords: antioxidants; electroactivity; injectable hydrogels; tetraaniline; tissue engineering