title: Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1.
abstract: Genome level analysis of bacterial strains provides information on genetic composition and resistance mechanisms to clinically relevant antibiotics. To date, whole genome characterization of linezolid-resistant Enterococcus faecalis isolated in the clinic is lacking. In this study, we report the entire genome sequence, genomic characteristics and virulence factors of a pathogenic E. faecalis strain, DENG1. Our results showed considerable differences in genomic characteristics and virulence factors compared with other E. faecalis strains (V583 and OG1RF). The genome of this LZD-resistant E. faecalis strain can be used as a reference to study the mechanism of LZD resistance and the phylogenetic relationship of E. faecalis strains worldwide.
authors.affiliation: Shenzhen Key Lab for Endogenous Infection, Department of Infectious Diseases, The Affiliated Shenzhen Nanshan Hospital, Guangdong Medical College, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Yu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Hang
authors.initials: H
authors.lastname: Cheng
authors.forename: Jinxin
authors.initials: J
authors.lastname: Zheng
authors.forename: Duoyun
authors.initials: D
authors.lastname: Li
authors.forename: Xiangbin
authors.initials: X
authors.lastname: Deng
authors.forename: Weiguang
authors.initials: W
authors.lastname: Pan
authors.forename: Weizhi
authors.initials: W
authors.lastname: Yang
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Deng
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D013293:Enterococcus faecalis / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D000069349:Linezolid; D023303:Oxazolidinones / Q000494:pharmacology; D010802:Phylogeny; D013045:Species Specificity; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D037521:Virulence Factors; D000069349:Linezolid