title: Hepatoprotective triterpenoid saponins from Callicarpa nudiflora.
abstract: Four new triterpenoid saponins, 2α,3α,19α,24-tetrahydroxyolean-12-en-28-oic-acid 28-O-β-D-glucopyranosyl ester (1), 2α,3α,19α,23-tetrahydroxyolean-12-en-28-oic-acid 28-O-β-D-xylopyranosyl-(1→2)-β-D-glu-copyranosyl ester (2), 2α,3α,19α-trihydroxyolean-12-en-28-oic-acid 28-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl ester (3), 2α,3α,23,29-tetrahydroxyurs-12,19-dien-28-oic-acid 28-O-β-D-glucopyranosyl ester (4), together with three known compounds (5-7), were isolated from the leaves of Callicarpa nudiflora HOOK. Their structures were established by means of spectroscopic methods and chemical evidence. Hepatoprotective activities of the isolated compounds against D-galactosamine-induced toxicity have been tested. Among them, compounds 1-3 showed pronounced hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality.
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.forename: Hui-Zheng
authors.initials: HZ
authors.lastname: Fu
authors.forename: Wei-Kang
authors.initials: WK
authors.lastname: Chen
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Luo
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
mesh_terms: D000818:Animals; D032408:Callicarpa / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005688:Galactosamine / Q000633:toxicity; D022781:Hepatocytes / Q000166:cytology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D020011:Protective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D020011:Protective Agents; D012503:Saponins; D014315:Triterpenes; D005688:Galactosamine