title: Polymorphism of DC-SIGN (CD209) promoter in association with clinical symptoms of dengue fever.
abstract: C-type lectin DC-SIGN receptor, encoded by CD209, plays a key role in the infection of dendritic cells by dengue virus (DENV). Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis. A control sample of 72 individuals, rigorously selected through a clinical investigation for absence of past dengue fever (DF) was compared to a sample of 168 patients (156 classical DF; 12 dengue hemorrhagic fever), all residents from Pará, Brazil. However, the prevalence of symptoms showed a trend higher in the AA genotype (Wilcoxon test; Z=2.02; p=0.04). Hence, our findings indicate that the G allele downregulates the spectrum of symptoms during the early acute phase of DENV infection, putatively decreasing the viremia, as suggested in the literature.
authors.affiliation: 1 Human and Medical Genetics, Federal University of Pará , Belém, Pará, Brazil .
authors.forename: Layanna Freitas de
authors.initials: LF
authors.lastname: Oliveira
authors.forename: Clayton Pereira Silva de
authors.initials: CP
authors.lastname: Lima
authors.forename: Raimunda do Socorro Silva
authors.initials: Rdo S
authors.lastname: Azevedo
authors.forename: Dafne Silva Furtado de
authors.initials: DS
authors.lastname: Mendonça
authors.forename: Sueli Guerreiro
authors.initials: SG
authors.lastname: Rodrigues
authors.forename: Valéria Lima
authors.initials: VL
authors.lastname: Carvalho
authors.forename: Eliana Vieira
authors.initials: EV
authors.lastname: Pinto
authors.forename: Andreza Lopes
authors.initials: AL
authors.lastname: Maia
authors.forename: Maria Helena Thomaz
authors.initials: MH
authors.lastname: Maia
authors.forename: Janaina Mota
authors.initials: JM
authors.lastname: Vasconcelos
authors.forename: Andrea Luciana Soares da
authors.initials: AL
authors.lastname: Silva
authors.forename: Márcio Roberto Teixeira
authors.initials: MR
authors.lastname: Nunes
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sena
authors.forename: Pedro Fernando
authors.initials: PF
authors.lastname: Vasconcelos
authors.forename: Eduardo José Melo dos
authors.initials: EJ
authors.lastname: Santos
mesh_terms: D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D003715:Dengue / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin