title: Mucin 1 gene (MUC1) and gastric-cancer susceptibility.
abstract: Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells; however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.
authors.affiliation: Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan. nsaeki@ncc.go.jp.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Saeki
authors.affiliation: Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan. hsakamot@ncc.go.jp.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakamoto
authors.affiliation: Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan. tyoshida@ncc.go.jp.
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism; D055785:Gene Knockdown Techniques; D055106:Genome-Wide Association Study; D016998:Helicobacter / Q000276:immunology / Q000302:isolation & purification; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000382:microbiology; D051379:Mice; D018396:Mucin-1 / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D013270:Stomach / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000276:immunology / Q000382:microbiology / Q000473:pathology*
chemical_list: D018396:Mucin-1