title: Versatile post-functionalization of the external shell of cowpea chlorotic mottle virus by using click chemistry.
abstract: We present the modification of the outer protein shell of cowpea chlorotic mottle virus (CCMV) with linear and strained alkyne groups. These functionalized protein capsids constitute valuable platforms for post-functionalization via click chemistry. After modification, the integrity of the capsid and the reversible disassembly behavior are preserved.
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. n.h.katsonis@utwente.nl.
authors.forename: C A
authors.initials: CA
authors.lastname: Hommersom
authors.forename: B
authors.initials: B
authors.lastname: Matt
authors.forename: A
authors.initials: A
authors.lastname: van der Ham
authors.forename: J J L M
authors.initials: JJ
authors.lastname: Cornelissen
authors.forename: N
authors.initials: N
authors.lastname: Katsonis
mesh_terms: D001386:Azides / Q000737:chemistry; D017795:Bromovirus / Q000737:chemistry* / Q000648:ultrastructure; D002213:Capsid / Q000737:chemistry* / Q000648:ultrastructure; D057930:Click Chemistry / Q000379:methods*; D008958:Models, Molecular; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001386:Azides