title: Tantalum electrodes modified with well-aligned carbon nanotube-Au nanoparticles: application to the highly sensitive electrochemical determination of cefazolin.
abstract: Carbon nanotube/nanoparticle hybrid materials have been proven to exhibit high electrocatalytic activity suggesting broad potential applications in the field of electroanalysis. For the first time, modification of Ta electrode with aligned multi-walled carbon nanotubes/Au nanoparticles introduced for the sensitive determination of the antibiotic drug, cefazolin (CFZ). The electrochemical response characteristics of the modified electrode toward CFZ were investigated by means of cyclic and linear sweep voltammetry. The modified electrode showed an efficient catalytic activity for the reduction of CFZ, leading to a remarkable decrease in reduction overpotential and a significant increase of peak current. Under optimum conditions, the highly sensitive modified electrode showed a wide linear range from 50 pM to 50 μM with a sufficiently low detection limit of 1 ± 0.01 pM (S/N = 3). The results indicated that the prepared electrode presents suitable characteristics in terms of sensitivity (458.2 ± 2.6 μAcm(-2)/μM), accuracy, repeatability (RSD of 1.8 %), reproducibility (RSD of 2.9 %), stability (14 days), and good catalytic activity in physiological conditions. The method was successfully applied for accurate determination of trace amounts of CFZ in pharmaceutical and clinical preparations without the necessity for samples pretreatment or any time-consuming extraction or evaporation steps prior to the analysis.
authors.affiliation: Materials Science and Engineering Department, Sharif University of Technology, Tehran, P.O. Box 11155-9466, I.R, Iran.
authors.forename: Haniyeh
authors.initials: H
authors.lastname: Fayazfar
authors.forename: Abdollah
authors.initials: A
authors.lastname: Afshar
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Dolati
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D001709:Biotechnology; D002437:Cefazolin / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods* / Q000706:statistics & numerical data; D004566:Electrodes; D006046:Gold; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000648:ultrastructure; D015203:Reproducibility of Results; D013635:Tantalum
chemical_list: D000900:Anti-Bacterial Agents; D037742:Nanotubes, Carbon; D013635:Tantalum; D006046:Gold; D002437:Cefazolin