title: Cardiovascular sequelae of radiation therapy.
abstract: Radiotherapy (RT) is one of the main therapeutic options for malignancy treatment; nevertheless, RT is not free from side effects, including an increased risk for secondary neoplasms and other organs injury. Cardiovascular complications are the second most frequent fatal post-RT sequelae, which physicians should be aware of and ready to diagnose early and cure. This review therefore aims to examine epidemiology, pathogenesis and clinical dose-correlated manifestations of RT-induced cardiovascular disease. Future perspectives on screening, prevention and treatment are also provided.
authors.affiliation: Cardiology Department, University of Foggia, Viale Pinto 1, 71100, Foggia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Santoro
authors.forename: Nicola
authors.initials: N
authors.lastname: Tarantino
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Pellegrino
authors.forename: Marica
authors.initials: M
authors.lastname: Caivano
authors.forename: Agostino
authors.initials: A
authors.lastname: Lopizzo
authors.forename: Matteo
authors.initials: M
authors.lastname: Di Biase
authors.forename: Natale Daniele
authors.initials: ND
authors.lastname: Brunetti
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D002319:Cardiovascular System / Q000528:radiation effects*; D014943:Global Health; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000150:complications / Q000453:epidemiology*