title: Report: investigation of anti-cancer effects of cherry in vitro.
abstract: Cherry (Prunus Cerasus) is still one of the most popular preserve in Turkish cuisine. Cherry has been traditionally used for the treatment of inflammatory-related symptoms. Recent researches have proved that cherry is a valuable natural source of some important bioactive compounds in human health preservation. Evidence suggests that, cherry consumption may decrease the risk of chronic diseases and cancer. The aim of the present study was to determine the effects of cherry on breast cancer cells lines, asymmetric dimethylarginine (ADMA) level and certain multidrug-resistant bacteria. The cancer cell proliferation activity and analysis of apoptotic-necrotic cells was evaluated by using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and scoring of apoptotic cell nuclei. Measurement of ADMA and the minimum inhibitory concentration was accomplished by HPLC and the micro dilution broth method. The results showed that, extracts of cherry exhibit anti-proliferative activity in mammary adenocarcinoma (MCF-7) & mouse mammary tumor cell (4T1) breast cancer cells lines as well as induction of apoptosis, lower ADMA concentrations in cell cultures treated with cherry extract and antibacterial effects against certain multidrug-resistant bacteria in vitro. These findings may open new horizons for traditional anti-inflammatory product as prophylactic-therapeutic agent from cancer, cardiovascular diseases and multidrug-resistant infections.
authors.affiliation: Department of Public Health, Division of Environmental Health, Gulhane Military Medicine Faculty, Etlik, Ankara, Turkey.
authors.forename: Recai
authors.initials: R
authors.lastname: Ogur
authors.affiliation: Department of Public Health, Gulhane Military Medicine Faculty, Etlik, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Istanbulluoglu
authors.affiliation: Department of Physiology, Gulhane Military Medicine Faculty, Etlik, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
authors.affiliation: Extraction Department Responsible, AROMSA Co., Istanbul, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Barla
authors.affiliation: Department of Public Health, Division of Environmental Health, Gulhane Military Medicine Faculty, Etlik, Ankara, Turkey.
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Tekbas
authors.affiliation: Department of Histology and Embriology, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Oztas
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D009336:Necrosis; D010936:Plant Extracts / Q000494:pharmacology*; D027861:Prunus
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts