title: Facile preparation of core-shell magnetic metal-organic framework nanospheres for the selective enrichment of endogenous peptides.
abstract: Facile preparation of core-shell magnetic metal-organic framework nanospheres by a layer-by-layer approach is presented. The nanospheres have high surface area (285.89 cm(2)  g(-1)), large pore volume (0.18 cm(3)  g(-1)), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g(-1)), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, Department of Chemistry and Molecular Engineering, East China University of Science and Technology (ECUST), 130 Meilong Road, Shanghai, 200237 (P.R. China), Fax: (+86) 021-64233161; Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian, 116023 (P.R. China), Fax:(+86) 0411-84379620.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Xiong
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Ji
authors.forename: Chunli
authors.initials: C
authors.lastname: Fang
authors.forename: Quanqing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lingyi
authors.initials: L
authors.lastname: Zhang
authors.forename: Mingliang
authors.initials: M
authors.lastname: Ye
authors.forename: Weibing
authors.initials: W
authors.lastname: Zhang
authors.forename: Hanfa
authors.initials: H
authors.lastname: Zou
mesh_terms: D060328:Magnetic Phenomena; D054118:Nanospheres; D010455:Peptides / Q000737:chemistry*; D055585:Physical Phenomena
chemical_list: D010455:Peptides
keywords: core-shell structures; magnetic properties; metal-organic frameworks; nanoparticles; peptides