title: Dpp/BMP signaling in flies: from molecules to biology.
abstract: Decapentaplegic (Dpp), the fly homolog of the secreted mammalian BMP2/4 signaling molecules, is involved in almost all aspects of fly development. Dpp has critical functions at all developmental stages, from patterning of the eggshell to the determination of adult intestinal stem cell identity. Here, we focus on recent findings regarding the transcriptional regulatory logic of the pathway, on a new feedback regulator, Pentagone, and on Dpp's roles in scaling and growth of the Drosophila wing.
authors.affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. Electronic address: fisun.hamaratoglu@unil.ch.
authors.forename: Fisun
authors.initials: F
authors.lastname: Hamaratoglu
authors.affiliation: Growth & Development, Biozentrum, University of Basel, Basel, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Affolter
authors.affiliation: Institute for Biology I, Albert-Ludwigs-University of Freiburg, Freiburg, Germany; Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany.
authors.forename: George
authors.initials: G
authors.lastname: Pyrowolakis
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008957:Models, Genetic; D015398:Signal Transduction / Q000235:genetics*; D014921:Wings, Animal / Q000196:embryology / Q000254:growth & development / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D016326:Extracellular Matrix Proteins; C562078:Magu protein, Drosophila; C064196:dpp protein, Drosophila
keywords: Activating Element; Brinker; Dally; Daughters-against-dpp; Dpp; Drosophila; Feedback regulation; Growth; Morphogen; Optomotor-blind; Patterning; Pentagone; Scaling; Silencer Element; Spalt