title: Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis.
abstract: A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a polymorphism. Case-control, cohort or cross-sectional studies evaluating the association between eNOS 4b/a polymorphism and CAD susceptibility were systematically identified in PubMed up to 31 October 2013. Pooled odds ratios (OR) and corresponding 95% confidence intervals (CIs) were calculated to assess the association in overall and subgroup analyses. A total of 10,617 cases and 8302 controls from 37 studies were included in the study. The results of overall analysis revealed significant positive associations between CAD risk and eNOS 4b/a polymorphism in homozygote comparisons (OR = 1.47, 95% CI = 1.16-1.87), heterozygote comparisons (OR = 1.14, 95% CI = 1.02-1.27) and dominant models (OR = 1.18, 95% CI = 1.06-1.33). In subgroup analyses, similar associations were identified in African individuals, as determined using population-based source subgroups and noted in small-and-moderate sample size subgroups (case sample size or control sample size <500). The current meta-analysis revealed that eNOS 4b/a polymorphisms could be a risk factor for developing CAD, particularly in African populations and population-based subgroups.
authors.affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. yangyujiao626@126.com.
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. dukang@njmu.edu.cn.
authors.forename: Kang
authors.initials: K
authors.lastname: Du
authors.affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. liuzx0503@gmail.com.
authors.forename: Zhengxia
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. luxiang66@njmu.edu.cn.
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
mesh_terms: D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III