title: Complete genome analysis of human enterovirus B73 isolated from an acute flaccid paralysis patient in Shandong, China.
abstract: Human enterovirus B73 (EV-B73) is a member of species Enterovirus B. To date, only one complete genome sequence of prototype strain CA55-1988 from California has been available. In this study, the complete genome analysis of an EV-B73 strain 088/SD/CHN/04 isolated from an acute flaccid paralysis case in Shandong Province, China in 2004 is conducted. It had 75.6 and 79.3 % nucleotide similarity with prototype strain CA55-1988 in the VP1 coding region and the complete genome, respectively. It had great VP1 nucleotide divergence (16.7-24.4 %) with EV-B73 strains from other parts of the world. Similarity plot and bootscanning analyses provided evidence of recombination with other EV-B viruses.
authors.affiliation: Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992, Jingshi Road, Jinan, People's Republic of China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liu
authors.forename: Zexin
authors.initials: Z
authors.lastname: Tao
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Lin
authors.forename: Lizhi
authors.initials: L
authors.lastname: Song
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Suting
authors.initials: S
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Cui
authors.forename: Aiqiang
authors.initials: A
authors.lastname: Xu
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Song
mesh_terms: D002675:Child, Preschool; D002681:China; D016000:Cluster Analysis; D004770:Enterovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000821:virology*; D005260:Female; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010264:Paraplegia / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012367:RNA, Viral