title: [Application progress of seed cells in tissue engineered nerve].
abstract: OBJECTIVE
  To summarize the applications of Schwann cells (SCs), stem cells, and genetically modified cells (GMCs) in repair of peripheral nerve defects.
  
  
  METHODS
  The literature of original experimental study and clinical research related with SCs, stem cells, and GMCs was reviewed and analyzed.
  
  
  RESULTS
  SCs play a key role in repair of peripheral nerve defects; the stem cells can be induced to differentiate into SCs, which can be implanted into nerve conduits to promote the repair of peripheral nerve defect; genetically modified technology can enhance the function of SCs and different stem cells, which has been regarded as a new option for tissue engineered nerve.
  
  
  CONCLUSIONS
  Although great progress has been made in tissue engineered nerve recently, mostly limited to the experimental stage. The research of seed cells in application of tissue engineered nerve need be studied deeply.
authors.forename: Chunbo
authors.initials: C
authors.lastname: Li
authors.forename: Zenggan
authors.initials: Z
authors.lastname: Chen
authors.forename: Tongyi
authors.initials: T
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries / Q000601:surgery; D012583:Schwann Cells / Q000166:cytology* / Q000637:transplantation; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D009414:Nerve Growth Factors