title: Inhaled versus nebulised tobramycin: a real world comparison in adult cystic fibrosis (CF).
abstract: BACKGROUND
  There are no published data on real-life clinical experience comparing inhaled antibiotic therapy via new rapid delivery systems with nebulised antibiotic therapy in CF. This real world study compares safety, effectiveness and tolerability using tobramycin inhaled powder (TIP) versus tobramycin inhaled solution (TIS).
  
  
  METHODS
  Adult patients with CF commencing TIP (n=78) completed a questionnaire assessing safety, efficacy, tolerability, patient-satisfaction and self-reported adherence to TIS at baseline and during 12 months of TIP therapy. FEV1% predicted and exacerbation rate were recorded at each visit.
  
  
  RESULTS
  There was a significant improvement in adherence scores, with a significant decrease in the number of intravenous antibiotic courses received during 12 months of TIP compared with the preceding 12 months using TIS. 94% of patients who had previously used TIS preferred TIP therapy over TIS.
  
  
  CONCLUSIONS
  Inhaled powder tobramycin in CF is associated with improved adherence, tolerability and decreased exacerbation rates compared to nebulised treatment in real-life practice.
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Harrison
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: McCarthy
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Fleming
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Hickey
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Shortt
authors.affiliation: HRB Clinical Research Facility, University College Cork, Cork, Ireland.
authors.forename: J A
authors.initials: JA
authors.lastname: Eustace
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland.
authors.forename: D M
authors.initials: DM
authors.lastname: Murphy
authors.affiliation: Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland. Electronic address: b.plant@ucc.ie.
authors.forename: B J
authors.initials: BJ
authors.lastname: Plant
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D017060:Patient Satisfaction; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa; D011795:Surveys and Questionnaires; D014031:Tobramycin / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin