title: Segmental testicular infarction due to minocycline-induced antineutrophil cytoplasmic antibody--positive vasculitis.
abstract: Segmental testicular infarction is an uncommon clinical entity marked by acute scrotal pain and swelling. Classically, these appear as wedge-shaped, avascular, hypoechoic lesions on a testicular ultrasound. We present a unique case of testicular infarct caused by an antineutrophil cytoplasmic antibody-positive vasculitis secondary to the use of the antibiotic minocycline. The patient's symptoms resolved with cessation of minocycline. We suggest that patients who present with otherwise unexplained testicular infarction undergo a careful review of medications to uncover a potential cause.
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address: lyontd@upmc.edu.
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Lyon
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Ferroni
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Casella
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Louis A
authors.initials: LA
authors.lastname: D'Agostino
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Jackman
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000187:drug effects*; D006801:Humans; D007238:Infarction / Q000382:microbiology*; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D013737:Testis / Q000098:blood supply*; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D008911:Minocycline