title: Post-translational modifications of tubulin.
abstract: Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism to generate microtubule identities. As many microtubule functions have direct implications for development and homeostasis of organisms, understanding the molecular functions of tubulin PTMs could provide a more differentiated view on the role of microtubules in both normal and pathological aspects of organism development.
authors.affiliation: Institut Curie, CNRS UMR3306, INSERM U1005, Centre Universitaire, Bâtiment 110, 91405 Orsay, France.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Magiera
authors.affiliation: Institut Curie, CNRS UMR3306, INSERM U1005, Centre Universitaire, Bâtiment 110, 91405 Orsay, France. Electronic address: carsten.janke@curie.fr.
authors.forename: Carsten
authors.initials: C
authors.lastname: Janke
mesh_terms: D000107:Acetylation; D000586:Amination; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D048430:Cell Shape / Q000502:physiology; D003599:Cytoskeleton / Q000235:genetics / Q000502:physiology; D008870:Microtubules / Q000378:metabolism*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D014404:Tubulin / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
chemical_list: D014404:Tubulin