title: Evaluation of the hemodynamic effectiveness of aortic dissection treatments via virtual stenting.
abstract: Aortic dissection treatment varies for each patient and stenting is one of a number of approaches that are utilized to Stabilize the condition. Information regarding the hemodynamic forces in the aorta in dissected and virtually stented cases could support clinicians in their choices of treatment prior to medical intervention. Computational fluid dynamics coupled with lumped parameter models have shown promise in providing detailed information that could be used in the clinic; for this, it is necessary to develop personalized workflows in order to produce patient-specific simulations. In the present study, a case of pre- and post-stenting (virtual stent-graft) of an aortic dissection is investigated with a particular focus on the role of personalized boundary conditions. For each virtual case, velocity, pressure, energy loss, and wall shear stress values are evaluated and compared. The simulated single stent-graft only marginally reduced the pulse pressure and systemic energy loss. The double stent-graft results showed a larger reduction in pulse pressure and a 40% reduction in energy loss as well as a more physiological wall shear stress distribution.Regions of potential risk were highlighted. The methodology applied in the present study revealed detailed information about two possible surgical outcome cases and shows promise as both a diagnostic and an interventional tool.
authors.affiliation: 1 Department of Mechanical Engineering, University College London, London - UK.
authors.forename: Mona
authors.initials: M
authors.lastname: Alimohammadi
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bhattacharya-Ghosh
authors.forename: Santhosh
authors.initials: S
authors.lastname: Seshadhri
authors.forename: Justin
authors.initials: J
authors.lastname: Penrose
authors.forename: Obiekezie
authors.initials: O
authors.lastname: Agu
authors.forename: Stavroula
authors.initials: S
authors.lastname: Balabani
authors.forename: Vanessa
authors.initials: V
authors.lastname: Díaz-Zuccarini
mesh_terms: D000784:Aortic Dissection / Q000000981:diagnostic imaging / Q000601:surgery*; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging / Q000601:surgery*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D057446:Hydrodynamics; D008875:Middle Aged; D008955:Models, Cardiovascular; D011859:Radiography; D015607:Stents; D013526:Surgical Mesh