title: Deciphering functions of branched ubiquitin chains.
abstract: The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
authors.affiliation: Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
authors.forename: Jaime
authors.initials: J
authors.lastname: López-Mosqueda
authors.affiliation: Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address: dikic@biochem2.uni-frankfurt.de.
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D059748:Proteolysis
chemical_list: D064173:Anaphase-Promoting Complex-Cyclosome; D046988:Proteasome Endopeptidase Complex