title: Axon and dendrite pruning in Drosophila.
abstract: Pruning, a process by which neurons selectively remove exuberant or unnecessary processes without causing cell death, is crucial for the establishment of mature neural circuits during animal development. Yet relatively little is known about molecular and cellular mechanisms that govern neuronal pruning. Holometabolous insects, such as Drosophila, undergo complete metamorphosis and their larval nervous systems are replaced with adult-specific ones, thus providing attractive models for studying neuronal pruning. Drosophila mushroom body and dendritic arborization neurons have been utilized as two appealing systems to elucidate the underlying mechanisms of axon and dendrite pruning, respectively. In this review we highlight recent developments and discuss some similarities and differences in the mechanisms that regulate these two distinct modes of neuronal pruning in Drosophila.
authors.affiliation: Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore 117604, Singapore. Electronic address: fengwei@tll.org.sg.
authors.forename: Fengwei
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Molecular Cell Biology, Weizmann Institute of Sciences, Rehovot 7610001, Israel. Electronic address: oren.schuldiner@weizmann.ac.il.
authors.forename: Oren
authors.initials: O
authors.lastname: Schuldiner
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D004330:Drosophila; D023421:Models, Animal; D009420:Nervous System / Q000166:cytology* / Q000254:growth & development; D009474:Neurons / Q000502:physiology*