title: Antioxidant activity of idebenone-loaded neutral and cationic solid-lipid nanoparticles.
abstract: Idebenone (IDE) is a lipophilic benzoquinone electron carrier synthetic analogue of coenzyme Q10, which behaves as an antioxidant and free radical scavenging molecule. Recently, the therapeutic application of IDE in Leber's hereditary optic neuropathy has been discussed. This work was aimed at evaluating the encapsulation of IDE in solid-lipid nanoparticles (SLN). In particular, we tested the possibility of adapting the quasi-emulsion solvent diffusion technique, already proposed to produce polymeric nanoparticles, to prepare positively charged SLN with different compositions. Such a charge, due to the addition of a cationic lipid, would facilitate the interaction with the negatively charged eye surface epithelium, with a consequent longer pre-corneal residence time of the colloidal systems. In a preliminary evaluation of the produced IDE-loaded SLN, the antioxidant activity of the drug was demonstrated using an oxygen radical absorbance capacity assay. Encapsulation of the drug in the nanocarrier systems seems able to protect IDE from degradation and prolong its antioxidant potential.
authors.affiliation: Department of Drug Sciences, University of Catania , Catania , Italy and.
authors.forename: Antonio
authors.initials: A
authors.lastname: Leonardi
authors.forename: Lucia
authors.initials: L
authors.lastname: Crasci'
authors.forename: Annamaria
authors.initials: A
authors.lastname: Panico
authors.forename: Rosario
authors.initials: R
authors.lastname: Pignatello
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D002412:Cations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002412:Cations; D004337:Drug Carriers; D008055:Lipids; D017382:Reactive Oxygen Species; D014451:Ubiquinone; C036619:idebenone
keywords: Drug delivery; idebenone; nanomedicine; solid–lipid nanoparticles