title: An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children.
abstract: In childhood, excess adiposity and low fitness are linked to poor academic performance, lower cognitive function, and differences in brain structure. Identifying ways to mitigate obesity-related alterations is of current clinical importance. This study examined the effects of an 8-month exercise intervention on the uncinate fasciculus, a white matter fiber tract connecting frontal and temporal lobes. Participants consisted of 18 unfit, overweight 8- to 11-year-old children (94% Black) who were randomly assigned to either an aerobic exercise (n = 10) or a sedentary control group (n = 8). Before and after the intervention, all subjects participated in a diffusion tensor MRI scan. Tractography was conducted to isolate the uncinate fasciculus. The exercise group showed improved white matter integrity as compared to the control group. These findings are consistent with an emerging literature suggesting beneficial effects of exercise on white matter integrity.
authors.affiliation: Department of Neuroscience, University of Georgia, Athens, Georgia, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Schaeffer
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Krafft
authors.forename: Nicolette F
authors.initials: NF
authors.lastname: Schwarz
authors.forename: Lingxi
authors.initials: L
authors.lastname: Chi
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Rodrigue
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Pierce
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Allison
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Yanasak
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Davis
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: McDowell
mesh_terms: D002648:Child; D056324:Diffusion Tensor Imaging; D005081:Exercise Therapy; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D050177:Overweight / Q000473:pathology / Q000628:therapy*; D013702:Temporal Lobe / Q000473:pathology*; D016896:Treatment Outcome; D066127:White Matter / Q000473:pathology*
keywords: Children; Diffusion tensor imaging; Exercise; Obesity; Uncinate fasciculus