title: Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis.
abstract: OBJECTIVE
  To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica.
  
  
  METHODS
  Fifty-seven SES; 36 with silicosis and 22 subjects in control group, were included in the study.
  
  
  RESULTS
  CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity.
  
  
  CONCLUSIONS
  sTNFR2 is associated with silicosis severity and early exposure to silica.
authors.affiliation: From the Programa Multicêntrico de Pós Graduação em Ciências Fisiológicas (Ms Braz and Drs Lacerda and Mendonça), Sociedade Brasileira de Fisiologia; Laboratório de Inflamação e Metabolismo-UFVJM (Ms Braz and Dr Mendonça), Diamantina; State Reference Center in Occupational Health (Dr Carneiro), the Clinics Hospital-UFMG, Belo Horizonte; Department of Physiology (Mr Amorim), School of Medicine of Ribeirão Preto-USP, Ribeirão Preto; Department of Basic Sciences-UFVJM (Dr de Oliveira Ferreira), Diamantina; Laboratório de Imunofarmacologia-ICB/UFMG (Ms Silva de Miranda and Drs M.M. Teixeira and A.L. Teixeira), Belo Horizonte, Brazil.
authors.forename: Nayara Felicidade Tomaz
authors.initials: NF
authors.lastname: Braz
authors.forename: Ana Paula Scalia
authors.initials: AP
authors.lastname: Carneiro
authors.forename: Mateus Ramos
authors.initials: MR
authors.lastname: Amorim
authors.forename: Fernanda
authors.initials: F
authors.lastname: de Oliveira Ferreira
authors.forename: Ana Cristina Rodrigues
authors.initials: AC
authors.lastname: Lacerda
authors.forename: Aline
authors.initials: A
authors.lastname: Silva de Miranda
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Vanessa Amaral
authors.initials: VA
authors.lastname: Mendonça
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational; D015415:Biomarkers / Q000097:blood; D019742:Chemokines, CC / Q000097:blood*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007107:Immune System / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D013902:Radiography, Thoracic; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000378:metabolism*; D012829:Silicosis / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D019742:Chemokines, CC; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha; D012822:Silicon Dioxide