title: Segmentectomy versus lobectomy for clinical stage IA lung adenocarcinoma.
abstract: BACKGROUND
  Despite the increasing prevalence of the early discovery of small-sized non-small cell lung cancers (NSCLCs), particularly adenocarcinoma, sublobar resection has not yet gained acceptance for patients who can tolerate lobectomy.
  
  
  METHODS
  We compared the outcomes of segmentectomy (n=155) and lobectomy (n=479) in 634 consecutive patients with clinical stage IA lung adenocarcinoma and in propensity score-matched pairs. Those who had undergone wedge resection were excluded.
  
  
  RESULTS
  The 30-day postoperative mortality rate in this population was zero. Patients with large or right-sided tumors, high maximum standardized uptake value (SUVmax), pathologically invasive tumors (with lymphatic, vascular, or pleural invasion), and lymph node metastasis underwent lobectomy significantly more often. Three-year recurrence-free survival (RFS) was significantly higher after segmentectomy compared to lobectomy (92.7% vs. 86.9%, P=0.0394), whereas three-year overall survival (OS) did not significantly differ (95.7% vs. 94.1%, P=0.162). Multivariate analyses of RFS and OS revealed age and SUVmax as significant independent prognostic factors, whereas gender, tumor size and procedure (segmentectomy vs. lobectomy) were not. In 100 propensity score-matched pairs with variables adjusted for age, gender, tumor size, SUVmax, tumor location, the three-year RFS (90.2% vs. 91.5%) and OS (94.8% vs. 93.3%) after segmentectomy and lobectomy respectively were comparable.
  
  
  CONCLUSIONS
  Segmentectomy with reference to SUVmax should be considered as an alternative for clinical stage IA adenocarcinoma, even for low-risk patients.
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Morihito
authors.initials: M
authors.lastname: Okada
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mimae
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsutani
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakayama
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Sakae
authors.initials: S
authors.lastname: Okumura
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura
authors.affiliation: 1 Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan ; 2 Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan ; 3 Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan ; 4 Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyata
keywords: Adenocarcinoma; lobectomy; lung cancer; segmentectomy; sublobar resection