title: [Optimization of pharmacotherapy in patients with essential hypertension with neurohumoral modulators with consideration of data on heart rate variability].
abstract: Long-term treatment of patients with essential hypertension (EH) and autonomic dysfunction (sympathicotonia type) with lisinopril in combination with indapamide augmented activity of humoral systems and improved heart rate variability. Addition of a selective beta-blocker bisoprolol to lisinopril/indapamide combination promoted normalization of humoral activity. This gives reason to apply tiered RAAS blockade in order to ensure more effective control of activity of neurohumoral systems in patients with EH ant initial sympathicotonia.
authors.forename: S M
authors.initials: SM
authors.lastname: Kakhramanova
authors.forename: A B
authors.initials: AB
authors.lastname: Bakhshaliev
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D016903:Drug Monitoring; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D000075222:Essential Hypertension; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D007190:Indapamide / Q000494:pharmacology*; D017706:Lisinopril / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology; D012720:Severity of Illness Index; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D002317:Cardiovascular Agents; D018377:Neurotransmitter Agents; D017706:Lisinopril; D007190:Indapamide