title: Hypertensive heart disease and obesity: a complex interaction between hemodynamic and not hemodynamic factors.
abstract: The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.
authors.affiliation: Internal Medicine and Geriatrics, "Hypertension Excellence Centre" of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Italian National Research Centre on Aging "U. Sestilli", IRCCS-INRCA, via della Montagnola n. 81, 60127, Ancona, Italy, sarzani@univpm.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sarzani
authors.forename: Marica
authors.initials: M
authors.lastname: Bordicchia
authors.forename: Francesco
authors.initials: F
authors.lastname: Spannella
authors.forename: Paolo
authors.initials: P
authors.lastname: Dessì-Fulgheri
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fedecostante
mesh_terms: D050154:Adiposity; D000818:Animals; D001794:Blood Pressure; D015897:Comorbidity; D006331:Heart Diseases / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology; D045265:Natriuretic Peptides / Q000378:metabolism; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D015995:Prevalence; D012084:Renin-Angiotensin System; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D045265:Natriuretic Peptides