title: Nanostructured lipid carriers and their current application in targeted drug delivery.
abstract: In the last few decades, various drug-delivery technologies have emerged and a fascinating part of this has been the development of nanoscale drug delivery devices. Nanoparticles (NPs) and other colloidal drug-delivery systems modify the kinetics, drug distribution in the body and release profile of an associated drug. Nanostructured lipid carriers (NLCs) have been reported to be an alternative system to emulsions, liposomes, microparticles, solid lipid nanoparticles (SLNs) and their polymeric counterparts due to their numerous advantages. This paper basically reviews the types of NLCs, mechanism of skin penetration, stability related issues along with their production techniques, characterisation and applications towards targeted drug delivery.
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur, Chhattisgarh , India.
authors.forename: Piyush
authors.initials: P
authors.lastname: Jaiswal
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur, Chhattisgarh , India.
authors.forename: Bina
authors.initials: B
authors.lastname: Gidwani
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur, Chhattisgarh , India.
authors.forename: Amber
authors.initials: A
authors.lastname: Vyas
mesh_terms: D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004655:Emulsions; D005227:Fatty Acids / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010539:Permeability; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption / Q000502:physiology; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature
chemical_list: D003102:Colloids; D004337:Drug Carriers; D004655:Emulsions; D005227:Fatty Acids; D005989:Glycerides; D008081:Liposomes; D013501:Surface-Active Agents
keywords: nanoparticles; nanostructured lipid carriers; solid lipid nanoparticles; targeted delivery