title: Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.
abstract: While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncovered some disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron disease and the specific neurons involved in the disease. We will then describe recent progress to investigate common forms of motor neuron disease: amyotrophic lateral sclerosis, hereditary spastic paraplegia and spinal muscular atrophy.
authors.affiliation: IZKF Junior Research Group and BMBF Research Group Neuroscience, IZKF, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Glueckstrasse 6, Erlangen 91054, Germany beate.winner@med.uni-erlangen.de gage@salk.edu.
authors.forename: Beate
authors.initials: B
authors.lastname: Winner
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Marchetto
authors.affiliation: Department of Molecular Neurology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Schwabachanlage 6, Erlangen 91054, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Winkler
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA beate.winner@med.uni-erlangen.de gage@salk.edu.
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000628:therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000637:transplantation; D016472:Motor Neuron Disease / Q000235:genetics* / Q000628:therapy; D009046:Motor Neurons / Q000166:cytology; D009134:Muscular Atrophy, Spinal / Q000235:genetics* / Q000628:therapy; D009154:Mutation; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics* / Q000628:therapy