title: Expression and effects of JMJD2A histone demethylase in endometrial carcinoma.
abstract: Previous studies have demonstrated that JMJD2A is a potential oncogene and is overexpressed in human tumors. However, its role in the endometrial carcinoma remains largely unknown. In this study, we discovered that JMJD2A was overexpressed in endometrial carcinoma, using immunohistochemistry, quantitative real- time polymerase chain reaction, and western blotting. Downregulation of JMJD2A led to reduced endometrial carcinoma RL95-2 and ISK cell proliferation, invasion and metastasis as asessed with cell counting kit-8, cell migration and invasive assays. Collectively, our results support that JMJD2A is a promoter of endometrial carcinoma cell proliferation and survival, and is a potential novel drug target.
authors.affiliation: Department of Obstetrics and Gynaecology, Second Affiliated Hospital of Harbin Medical University, Heilongjiang, China E-mail : bonbon0451@126.com.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Mei-Mei
authors.initials: MM
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.forename: Zong-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Tie-Fang
authors.initials: TF
authors.lastname: Song
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Gao
authors.forename: Ye
authors.initials: Y
authors.lastname: Kuang
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Wang
authors.forename: Pei-Ling
authors.initials: PL
authors.lastname: Li
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015536:Down-Regulation; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D056484:Jumonji Domain-Containing Histone Demethylases / Q000096:biosynthesis* / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering
chemical_list: D006657:Histones; D034741:RNA, Small Interfering; D056484:Jumonji Domain-Containing Histone Demethylases; C494424:KDM4A protein, human