title: Elevated resistin levels are associated with inflammation in hemodialysis patients with failed renal allografts.
abstract: BACKGROUND
  Resistin is an adipocytokine, associated with insulin resistance and inflammation. The aim of this study is to evaluate the levels of serum resistin levels and other markers of inflammation in hemodialysis (HD) patients with failed renal allografts.
  
  
  METHODS
  Sixty-nine HD patients with failed renal allografts and 98 never transplanted (naive) HD patients and also 21 healthy controls were included in the study. Serum levels of various biochemical parameters as well as resistin, IL-6, TNF-α and hs-CRP as biochemical markers of inflammation, were measured.
  
  
  RESULTS
  Serum resistin levels in patients with failed renal allografts (4.80 ± 2.06 ng/mL) were significantly higher than those of the naive HD patients (3.44 ± 1.48 ng/mL) and healthy controls (0.95 ± 0.38 ng/mL; p<0.001). Patients with failed transplants were also characterized by higher TNF-alpha levels (96.8 ± 131.3 pg/mL vs. 40.9 ± 25.4 pg/mL; p<0.001) and IL-6 levels (83.9 ± 150.9 pg/mL vs. 14.6 ± 14.4 pg/mL; p<0.001) as compared to naive HD patients. Serum hs-CRP levels in patients with failed renal allografts (9.33 ± 11.86 mg/L) were significantly higher than those of the naive HD patients (1.26 ± 1.71 mg/L) and healthy controls (2.12 ± 1.82 mg/L; p<0.001). Serum albumin levels in patients with failed transplants (3.84 ± 0.47 g/dL) were lower as compared to never transplanted HD patients (4.13 ± 0.33 g/dL) and healthy controls (4.53 ± 0.40 g/dL; p<0.001). There was a positive correlation between serum resistin and TNF-alpha levels (r = 0.486, p<0.001).
  
  
  CONCLUSIONS
  Serum resistin levels are increased in HD patients with failed renal allografts very probably reflecting an allograft-induced chronic inflammatory state.
authors.affiliation: 1 Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul - Turkey.
authors.forename: Tulin
authors.initials: T
authors.lastname: Akagun
authors.forename: Yasar
authors.initials: Y
authors.lastname: Caliskan
authors.forename: Halil
authors.initials: H
authors.lastname: Yazici
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozkok
authors.forename: Aysegul
authors.initials: A
authors.lastname: Telci
authors.forename: Aydin
authors.initials: A
authors.lastname: Turkmen
authors.forename: Alaattin
authors.initials: A
authors.lastname: Yildiz
authors.forename: Mehmet Sukru
authors.initials: MS
authors.lastname: Sever
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D052243:Resistin / Q000097:blood*; D017211:Treatment Failure; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha