title: Nephroprotective potentials of Citrus aurantium: a prospective pharmacological study on experimental models.
abstract: Citrus aurantium is traditionally used in various kidney problems like burning of urine, urinary hesitancy and renal colic. The main objective of the present work was to evaluate the protective role of Citrus aurantium against gentamicin induced renal damage, due to its free radical scavenging properties to present experimental facts for their traditional use. 200 mg/kg/day of ethanolic extract of the plant employed in combination with the toxic doses of gentamicin for twenty-one days. The group GC-au (animals treated with co-administration of Citrus aurantium and gentamicin) protected renal damage expected with gentamicin, assessed by known functional and morphological parameters, significantly different from group G (animals treated with gentamicin). All the renal functioning parameters including; Blood urea nitrogen, Serum creatinine, Serum uric acid, Creatinine clearance, Serum electrolytes, Body weight, Urinary volume, Enzyme excretions, Urinary protein excretions and histological examination was performed for each and every group animals. The plant extract proved to have nephroprotective potentials may because of its known flavonoid contents and antioxidant properties.
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Ullah
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara Pakistan.
authors.forename: Mir Azam
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
authors.forename: Taous
authors.initials: T
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara Pakistan.
authors.forename: Waqar
authors.initials: W
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D002957:Citrus / Q000737:chemistry; D003404:Creatinine / Q000097:blood; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011446:Prospective Studies; D020011:Protective Agents / Q000494:pharmacology; D011817:Rabbits
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D003404:Creatinine