title: [New facts about the molecular background of isovanilline-type sweeteners].
abstract: As a continuation of our studies on the relationship between structure and sweet taste of isovanilline-type sweeteners, (3-hydroxy-4-methoxy)benzyl-benzoate (17) and -salicylate (17c), analogues of dihydrochalcone-type sweetener analogues of (+)-phyllodulcin [(+)-5] and CH-401 (14c) have been synthesized. Surprisingly, 17c has been found to be tastless, while 17e was slightly sweet. These observations could be explained by the current hypothesis on the receptor model for isovanilline-type sweet derivatives.
authors.forename: Noémi
authors.initials: N
authors.lastname: Kálmán
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Magyarné-Jeszenszki
authors.forename: Tibor
authors.initials: T
authors.lastname: Kurtán
authors.forename: Sándor
authors.initials: S
authors.lastname: Antus
mesh_terms: D001547:Benzaldehydes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*
chemical_list: D001547:Benzaldehydes; D047188:Chalcones; D049934:Isocoumarins; D013549:Sweetening Agents; C093382:isovanillin; C014263:CH 401-Na; D002599:Chalcone; C008903:phyllodulcin; C015812:dihydrochalcone