title: Differential effects of deep brain stimulation on verbal fluency.
abstract: We aimed at gaining insights into principles of subcortical lexical processing. Therefore, effects of deep brain stimulation (DBS) in different target structures on verbal fluency (VF) were tested. VF was assessed with active vs. inactivated DBS in 13 and 14 patients with DBS in the vicinity of the thalamic ventral intermediate nucleus (VIM) and, respectively, of the subthalamic nucleus (STN). Results were correlated to electrode localizations in postoperative MRI, and compared to those of 12 age-matched healthy controls. Patients' VF performance was generally below normal. However, while activation of DBS in the vicinity of VIM provoked marked VF decline, it induced subtle phonemic VF enhancement in the vicinity of STN. The effects correlated with electrode localizations in left hemispheric stimulation sites. The results show distinct dependencies of VF on DBS in the vicinity of VIM vs. STN. Particular risks for deterioration occur in patients with relatively ventromedial thalamic electrodes.
authors.affiliation: Charité, University Medicine Berlin, Dept. of Neurology, Motor and Cognition Group, Campus Benjamin Franklin, Germany. Electronic address: felicitas.ehlen@charite.de.
authors.forename: Felicitas
authors.initials: F
authors.lastname: Ehlen
authors.affiliation: Charité, University Medicine Berlin, Dept. of Neurology, Motor Neuroscience Group, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: thomas.schoenecker@charite.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schoenecker
authors.affiliation: Charité, University Medicine Berlin, Dept. of Neurology, Motor Neuroscience Group, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany. Electronic address: andrea.kuehn@charite.de.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kühn
authors.affiliation: Charité, University Medicine Berlin, Dept. of Neurology, Motor and Cognition Group, Campus Benjamin Franklin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany. Electronic address: fabian.klostermann@charite.de.
authors.forename: Fabian
authors.initials: F
authors.lastname: Klostermann
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D004566:Electrodes; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000534:rehabilitation; D010700:Phonetics; D012044:Regression Analysis; D013060:Speech / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000502:physiology*
keywords: DBS; Essential tremor; Localization; Parkinson’s disease; Verbal fluency