title: Association between serum 25-hydroxyvitamin D levels and TTN.
abstract: OBJECTIVE
  To investigate the association between serum 25-hydroxyvitamin D (25(OH)D3) levels and transient tachypnea of the newborn (TTN).
  
  
  METHODS
  Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D3 levels were measured in 51 infants diagnosed with TTN and 59 healthy control infants for comparison. Demographic factors including gestational age, birth weight, gender, delivery mode, parity, vitamin D supplementation during pregnancy and severity of TTN were recorded.
  
  
  RESULTS
  The serum levels of 25(OH)D3 were significantly lower in infants with TTN compared to infants with no respiratory distress (p < 0.01). There was no statistically significant difference in serum Ca, P and ALP levels between the groups while the serum levels of PTH were significantly higher in the study group (p < 0.01). No correlation was found between the serum 25(OH)D3 levels and severity of TTN. Vitamin D supplementation (400 IU/day) during pregnancy did not affect the serum levels of newborns.
  
  
  CONCLUSIONS
  Our data suggests that lower 25(OH)D3 serum levels are associated with an increased risk of TTN and vitamin D may have a role in the pathogenesis of TTN.
authors.affiliation: Department of Pediatrics, Neonatology Clinic, Adiyaman University, School of Medicine, Adiyaman, Turkey.
authors.forename: Capan
authors.initials: C
authors.lastname: Konca
authors.forename: Zelal
authors.initials: Z
authors.lastname: Kahramaner
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bulbul
authors.forename: Aydin
authors.initials: A
authors.lastname: Erdemir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tekin
authors.forename: Sumeyye
authors.initials: S
authors.lastname: Ercan
authors.forename: Sedat
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Abdullah
authors.initials: A
authors.lastname: Arpaci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Turgut
mesh_terms: D000328:Adult; D002112:Calcifediol / Q000097:blood*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010281:Parathyroid Hormone / Q000097:blood; D011247:Pregnancy; D059245:Transient Tachypnea of the Newborn / Q000097:blood*; D014807:Vitamin D / Q000008:administration & dosage
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D002112:Calcifediol