title: One-shot, low-dosage intratympanic gentamicin for Ménière's disease: Clinical, posturographic and vestibular test findings.
abstract: BACKGROUND
  Ménière's disease has been remained as a difficult therapeutic challenge. The present study aimed to determine the effects of one-shot low-dosage intratympanic gentamicin on vertigo control, auditory outcomes and findings of computerized dynamic posturography and vestibular evoked myogenic potentials in patients with unilateral Ménière's disease.
  
  
  METHODS
  In a prospective clinical study, 30 patients with unilateral Ménière's disease were treated with one-shot intratympanic injection of 20 milligrams gentamicin. Main outcome measures included clinical, audiometric, postural and vestibular outcomes evaluated 1 and 9 months after the treatment.
  
  
  RESULTS
  Mean vertigo attacks frequency, pure tone average threshold and functional level scale significantly decreased after the treatment (P < 0.05). Effective vertigo control (class A and B) obtained in 95.8% of the patients. In total, 75% of patients reported decrease in both aural fullness and tinnitus. Vestibular evoked myogenic potentials became absent in all the patients but four of them. Posturographic scores were improved after the treatment.
  
  
  CONCLUSIONS
  One-shot low-dosage gentamicin was effective in controlling vertigo attacks in Ménière's disease and has useful effects on aural fullness and tinnitus of patients as well. Postural and vestibular tests only have adjunctive role for monitoring therapeutic responses in intratympanic gentamicin-therapy.
authors.affiliation: Department and Research Center of Otolaryngology-Head and Neck Surgery, Hazrat-e-Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Daneshi
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hesam
authors.initials: H
authors.lastname: Jahandideh
authors.affiliation: Department and Research Center of Otolaryngology-Head and Neck Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Behzad
authors.initials: SB
authors.lastname: Pousti
authors.affiliation: Department and Research Center of Otolaryngology-Head and Neck Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Shabahang
authors.initials: S
authors.lastname: Mohammadi
keywords: Dynamic Posturography; Gentamicin; Ménière's Disease; Vestibular Evoked Myogenic Potentials