title: Oral complications in hematopoietic stem cell recipients: the role of inflammation.
abstract: Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.
authors.affiliation: Department of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands.
authors.forename: T M
authors.initials: TM
authors.lastname: Haverman
authors.affiliation: Department of Oral- and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands ; Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Raber-Durlacher
authors.affiliation: Department of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands.
authors.forename: W M H
authors.initials: WM
authors.lastname: Rademacher
authors.affiliation: Department of Haemato-Oncology, University Hospital and Charles University Faculty of Medicine Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Vokurka
authors.affiliation: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA ; Department of Otolaryngology and Head and Neck Surgery, City of Hope National Medical Center, City of Hope, 1500 East Duarte Road, Duarte, CA, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Epstein
authors.affiliation: Department of Hematology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Huisman
authors.affiliation: Department of Hematology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: M D
authors.initials: MD
authors.lastname: Hazenberg
authors.affiliation: Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: de Soet
authors.affiliation: Department of Oral- and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: de Lange
authors.affiliation: Department of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands ; Department of Oral- and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands ; Department of Oral- and Maxillofacial Surgery, VU University Medical Center, VU University, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands.
authors.forename: F R
authors.initials: FR
authors.lastname: Rozema
mesh_terms: D000284:Administration, Oral; D006086:Graft vs Host Disease / Q000209:etiology / Q000378:metabolism; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D052016:Mucositis / Q000209:etiology / Q000378:metabolism