title: Effects of endocrine disruptors on the human fetal testis.
abstract: The modern societies are exposing us to a huge variety of potentially harmful pollutants. Among these endocrine disruptors (EDs) have been especially scrutinized as several were proven to display reprotoxic effects in rodent models. In the context of high and growing concerns about the reprotoxicity of EDs, it is crucial to carry out studies in order to assess their impact on the human reproductive function. However, such evidence remains scarce. The fetal period is critical for the proper development of the testis and is known as a period of high sensitivity to many EDs. Our team has shown in 2009 that a phthalate, mono-(2-ethylhexyl) phthalate (MEHP), has a potential deleterious effect on the development of human male germ cells. This result was the first direct experimental proof of the toxic effect of an ED in human testis. More recently, we also reported that bisphenol A (BPA) impaired testosterone production in the human fetal testis. Here, we will summarize the known effects of EDs on the various cell types composing the human developing testis and discuss their relevancy to propose future directions.
authors.affiliation: UMR 967, Inserm, CEA, DSV/iRCM/SCSR/LDG, unit of stem cells and radiation, laboratory of development of the gonads, university Paris Diderot, Sorbonne Paris Cité, route du panorama, BP 6, 92265 Fontenay-aux-Roses, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Rouiller-Fabre
authors.affiliation: UMR 967, Inserm, CEA, DSV/iRCM/SCSR/LDG, unit of stem cells and radiation, laboratory of development of the gonads, university Paris Diderot, Sorbonne Paris Cité, route du panorama, BP 6, 92265 Fontenay-aux-Roses, France.
authors.forename: René
authors.initials: R
authors.lastname: Habert
authors.affiliation: UMR 967, Inserm, CEA, DSV/iRCM/SCSR/LDG, unit of stem cells and radiation, laboratory of development of the gonads, university Paris Diderot, Sorbonne Paris Cité, route du panorama, BP 6, 92265 Fontenay-aux-Roses, France. Electronic address: gabriel.livera@cea.fr.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Livera
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology / Q000633:toxicity; D012734:Disorders of Sex Development / Q000139:chemically induced; D052244:Endocrine Disruptors / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D064593:Heterografts; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009845:Oligospermia / Q000139:chemically induced; D009924:Organ Culture Techniques; D010636:Phenols / Q000494:pharmacology / Q000633:toxicity; D010795:Phthalic Acids / Q000494:pharmacology / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D013736:Testicular Neoplasms / Q000139:chemically induced; D013737:Testis / Q000166:cytology / Q000187:drug effects* / Q000196:embryology; D013739:Testosterone / Q000096:biosynthesis; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D010795:Phthalic Acids; D013739:Testosterone; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Developing gonads; Endocrine disruptors; Gonades fœtales; Human health; Perturbateurs endocriniens; Reprotoxicity; Reprotoxicité; Santé humaine