title: [Influencing factors of whole blood colloid osmotic pressure in critically ill patients].
abstract: OBJECTIVE
  To analyze the influencing factors of whole blood colloid osmotic pressure (COP) and predict reference range of plasma protein for safe COP to guide clinical infusion of protein in critically ill patients.
  
  
  METHODS
  Physical data and blood gas analysis of 405 patients were collected. The patients were divided into 2 groups by COP: group A (COP≤18 mmHg) and group B (COP>18 mmHg). The serum proteins including total protein (TP), albumin (Alb), globumin (Glb) and fibrinogen (FIB) were detected.
  
  
  RESULTS
  APACHE II of group B was significantly lower than that of group A (P<0.05). The survival rate, TP, Alb, Glb and FIB of group B were significantly higher than these of group A (P<0.05). Standardized regression coefficient of Alb, Glb and FIB was 0.518, 0.283 and 0.113 (P<0.05); the 95% reference range of 4 types of protein level in group B: Alb>23.3 g/L, Glb 12.6-37.6 g/L and FIB 1.3-8.7 g/L; 5 reformed equations were made.
  
  
  CONCLUSIONS
  The main influencing factors of COP include Alb, Glb and FIB. We can use the reference range of 4 types of protein level to guide the clinical management of protein agents, and reformed equations can be used to preliminarily forecast COP in critically ill patients.
authors.affiliation: Intensive Care Unit, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Ai
mesh_terms: D001798:Blood Proteins / Q000032:analysis*; D003102:Colloids / Q000032:analysis*; D016638:Critical Illness; D006801:Humans; D008991:Monitoring, Physiologic; D009997:Osmotic Pressure; D012016:Reference Values
chemical_list: D001798:Blood Proteins; D003102:Colloids