title: The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro.
abstract: Endometrial carcinoma is the most common gynaecological malignancy. Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are three fungi widely used in traditional Chinese medicine, and effects as adjuvants in tumour therapy have been demonstrated. However, the function and effects of these fungi in regard to endometrial cancer are not known. Three endometrial cancer cell lines, Ishikawa, Hec-1A and AN3-CA (derived from endometrial cancers grade I, II and III, respectively), were used to determine the effect of the fungi extracts on endometrial cancer cell function and to analyze the molecular mechanism. All fungi extracts had an inhibitory effect on cell viability and proliferation most probably exerted through induction of autophagy. Our data suggest that these fungi extracts may be used as adjuvants in endometrial tumour therapy.
authors.affiliation: Department of Gynecology, Medical University of Würzburg, D-97080 Würzburg, Germany.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Hahne
authors.affiliation: Department of Gynecology, Medical University of Würzburg, D-97080 Würzburg, Germany.
authors.forename: Susanne R
authors.initials: SR
authors.lastname: Meyer
authors.affiliation: Department of Gynecology, Medical University of Würzburg, D-97080 Würzburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Dietl
authors.affiliation: Department of Gynecology, Medical University of Würzburg, D-97080 Würzburg, Germany.
authors.forename: Arnd
authors.initials: A
authors.lastname: Honig
mesh_terms: D000364:Agaricus / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001343:Autophagy / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D017024:Chemotherapy, Adjuvant; D032661:Cordyceps / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D020940:Reishi / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal