title: Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123.
abstract: One novel pentacyclic depsidone containing an oxetane unit, phomopsidone A (1), together with the reported excelsione (also named as phomopsidone) (2), and four known isobenzofuranones (3-6) were isolated from the mangrove endophytic fungus Phomopsis sp. A123. Their structures were elucidated by 1D and 2D NMR spectroscopic analysis and high resolution mass spectrometry. The bioactivity assays showed that these compounds possess cytotoxic, antioxidant, and antifungal activities.
authors.affiliation: Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, PR China; School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China; Basic Medicine College, Putian University, Putian, Fujian 351100, PR China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Xu
authors.affiliation: School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China.
authors.forename: Lishan
authors.initials: L
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China.
authors.forename: Yaojian
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, PR China.
authors.forename: Shengying
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Life Sciences, Shandong University, Jinan, Shandong 250100, PR China. Electronic address: yshen@sdu.edu.cn.
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000009:adverse effects; D002470:Cell Survival / Q000187:drug effects; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D060026:Endophytes; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010851:Picrates / Q000009:adverse effects; D043982:Rhizophoraceae / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D001713:Biphenyl Compounds; D053630:Depsides; D016166:Free Radical Scavengers; D007783:Lactones; D010851:Picrates; C518562:excelsione; C522036:phomopsidone; C000875:depsidone; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Cytotoxicity; Depsidones; Endophyte; Isobenzofuranones; Phomopsis