title: [Study on solubilization effect of solid dispersion technology and inclusion technology on pulsatillae total saponins].
abstract: OBJECTIVE
  To study the effect of solid dispersion technology and inclusion technology on dissolution performance of Pulsatillae total saponins, and preliminarily investigate its mechanism.
  
  
  METHODS
  The solid dispersion of Pulsatillae total saponins-PEG 4000 was prepared by the melting method. The inclusion compound of Pulsatillae total saponins-hydroxypropyl-beta-cyclodextrin ( HP-beta-CD) was prepared by the freeze-drying method. The properties of solid dispersion and inclusion compound were identified by using IR, DSC and NMR. And the dissolution of solid dispersion and inclusion compound were also determined by the small glass method.
  
  
  RESULTS
  IR, DSC and NMR results showed the formation of solid dispersion and inclusion compound. In terms of the dissolution, the inclusion compound ranked first, which was followed by solid dispersion and bulk pharmaceutical chemicals.
  
  
  CONCLUSIONS
  The inclusion technology could significantly increase the dissolution of Pulsatillae total saponins, whereas the solid dispersion showed no notable solubilization effect.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Guan
authors.forename: Ni
authors.initials: N
authors.lastname: Zhang
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Hong-Ning
authors.initials: HN
authors.lastname: Liu
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Zhu
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; C540801:pulsatillae