title: Ultrasmall Au(10-12)(SG)(10-12) nanomolecules for high tumor specificity and cancer radiotherapy.
abstract: Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12 (SG)10-12 ) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
authors.affiliation: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhang
authors.forename: Zhentao
authors.initials: Z
authors.lastname: Luo
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Xiu
authors.initials: X
authors.lastname: Shen
authors.forename: Shasha
authors.initials: S
authors.lastname: Song
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Sun
authors.forename: Saijun
authors.initials: S
authors.lastname: Fan
authors.forename: Feiyue
authors.initials: F
authors.lastname: Fan
authors.forename: David Tai
authors.initials: DT
authors.lastname: Leong
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D005978:Glutathione / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D011838:Radiation-Sensitizing Agents; D006046:Gold; D005978:Glutathione
keywords: gold nanoclusters; gold nanomolecules; radiosensitization; radiotherapy; tumor uptake