title: Characterization of pore structure in biologically functional poly(2-hydroxyethyl methacrylate)-poly(ethylene glycol) diacrylate (PHEMA-PEGDA).
abstract: A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surface architectures and pore morphologies were developed by adjusting porogen volume and type. The water and sucrose porogens were effective in creating porous and cytocompatible PHEMA-PEGDA scaffolds. When coated with collagen, the PHEMA-PEGDA scaffolds accommodated cell migration. The PHEMA-PEGDA scaffolds are easy to produce, non-toxic, and mechanically stable enough to resist fracture during routine handling. The PHEMA-PEGDA structures presented in this study may expedite the current research effort to engineer tissue scaffolds that provide both structural stability and biological activity.
authors.affiliation: Department of Bioengineering, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Amelia
authors.initials: A
authors.lastname: Zellander
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Chenlin
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Bioengineering, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Mrignayani
authors.initials: M
authors.lastname: Kotecha
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Richard
authors.initials: R
authors.lastname: Gemeinhart
authors.affiliation: Department of Bioengineering, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Melissa
authors.initials: M
authors.lastname: Wardlow
authors.affiliation: Department of Mechanical and Industrial Engineering, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Abiade
authors.affiliation: Department of Bioengineering, University of Illinois, Chicago, Illinois, United States of America.
authors.forename: Michael
authors.initials: M
authors.lastname: Cho
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry*; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D016062:Porosity; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; C437167:poly(ethylene glycol)diacrylate; D011102:Polyhydroxyethyl Methacrylate; D011092:Polyethylene Glycols; D003094:Collagen