title: Epidemiologic trends in head and neck cancer and aids in diagnosis.
abstract: Head and neck squamous cell carcinoma is the sixth most common cancer worldwide predominately associated with tobacco use. Changing cause and increased incidence in oropharyngeal carcinomas is associated with high-risk types of human papilloma virus and has an improved survival. Optical devices may augment visual oral examination; however, their lack of specificity still warrants tissue evaluation/biopsy. Histologic factors of oral carcinomas are critical for patient management and prognostic determination. Clinical biomarkers are still needed to improve early detection, predict malignant transformation, and optimize therapies.
authors.affiliation: Oral and Maxillofacial Pathology Biopsy Service, The University of Texas School of Dentistry at Houston, 1941 East Road BBSB, Room 5320, Houston, TX 77054, USA. Electronic address: nadarajah.vigneswaran@uth.tmc.edu.
authors.forename: Nadarajah
authors.initials: N
authors.lastname: Vigneswaran
authors.affiliation: Surgical Pathology Fellowship Program, Head & Neck Section, Department of Pathology, UT MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit #085, Houston, TX 77030, USA.
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Williams
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D002471:Cell Transformation, Neoplastic; D003952:Diagnostic Imaging; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D009059:Mouth Diseases / Q000150:complications; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D027383:Papillomaviridae; D011237:Predictive Value of Tests; D012307:Risk Factors; D014029:Tobacco Use Disorder / Q000150:complications
chemical_list: D014408:Biomarkers, Tumor
keywords: Diagnosis; Epidemiologic trends; Head and neck cancer; Squamous cell carcinomas