title: Proliferation at the heart of preadolescence.
abstract: Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for congenital and acquired heart diseases.
authors.affiliation: Departments of Pathology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Palpant
authors.affiliation: Departments of Pathology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Bioengineering, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Medicine/Cardiology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA. Electronic address: murry@uw.edu.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Murry
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006321:Heart / Q000254:growth & development*; D008297:Male; D032383:Myocytes, Cardiac / Q000166:cytology*