title: The role of inflammation in pancreatic cancer.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely poor prognosis. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. In genetically engineered mouse models, induction of pancreatitis accelerates PDAC development, and patients with chronic pancreatitis are known to have a higher risk of developing pancreatic cancer. In recent years, much effort has been given to identify the underlying mechanisms that contribute to inflammation-induced tumorigenesis. Many inflammatory pathways have been identified and inhibitors have been developed in order to prevent cancer development and progression. In this chapter, we discuss the role of inflammatory pathways in the initiation and progression of pancreatic cancer as well as the role of inhibitors used in treatment and prevention of pancreatic cancer.
authors.affiliation: Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Hausmann
authors.forename: Bo
authors.initials: B
authors.lastname: Kong
authors.forename: Christoph
authors.initials: C
authors.lastname: Michalski
authors.forename: Mert
authors.initials: M
authors.lastname: Erkan
authors.forename: Helmut
authors.initials: H
authors.lastname: Friess
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D051379:Mice; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D050500:Pancreatitis, Chronic / Q000150:complications* / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
chemical_list: D016207:Cytokines