title: Shared vs. specific brain activation changes in dyslexia after training of phonology, attention, or reading.
abstract: Whereas the neurobiological basis of developmental dyslexia has received substantial attention, only little is known about the processes in the brain during remediation. This holds in particular in light of recent findings on cognitive subtypes of dyslexia which suggest interactions between individual profiles, training methods, and also the task in the scanner. Therefore, we trained three groups of German dyslexic primary school children in the domains of phonology, attention, or visual word recognition. We compared neurofunctional changes after 4 weeks of training in these groups to those in untrained normal readers in a reading task and in a task of visual attention. The overall reading improvement in the dyslexic children was comparable over groups. It was accompanied by substantial increase of the activation level in the visual word form area (VWFA) during a reading task inside the scanner. Moreover, there were activation increases that were unique for each training group in the reading task. In contrast, when children performed the visual attention task, shared training effects were found in the left inferior frontal sulcus and gyrus, which varied in amplitude between the groups. Overall, the data reveal that different remediation programmes matched to individual profiles of dyslexia may improve reading ability and commonly affect the VWFA in dyslexia as a shared part of otherwise distinct networks.
authors.affiliation: Department of Psychiatry, Psychotherapy, and Psychosomatics, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany, s.heim@fz-juelich.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Heim
authors.forename: Julia
authors.initials: J
authors.lastname: Pape-Neumann
authors.forename: Muna
authors.initials: M
authors.lastname: van Ermingen-Marbach
authors.forename: Moti
authors.initials: M
authors.lastname: Brinkhaus
authors.forename: Marion
authors.initials: M
authors.lastname: Grande
mesh_terms: D001184:Articulation Disorders / Q000209:etiology*; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D004410:Dyslexia / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D011932:Reading; D013663:Teaching / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D010100:Oxygen