title: Vascular endothelial growth factor gene polymorphism (-634G/C) and breast cancer risk.
abstract: The aim of this meta-analysis was to assess if the -634G/C polymorphism represents a predisposition factor for the risk of breast cancer. We included eight published case-control studies, in which a total of 6,175 cancer cases and 6,421 cancer-free controls were included. Pooled ORs and 95 % CIs were calculated by the fixed effects model to evaluate the association of the -634G/C polymorphism and breast cancer risk. When all studies were pooled, we did not find statistical evidence of any significant association with overall breast cancer risk (ORBB vs. bb = 1.00, 95 % CI = 0.93-1.07, P = 0.999; ORBB + Bb vs. bb = 1.00, 95 % CI = 0.95-1.05, P = 0.999; ORBB vs. Bb + bb = 1.03, 95 % CI = 0.96-1.09, P = 0.984; ORallele B vs. allele b = 1.01, 95 % CI = 0.97-1.05, P = 0.998; ORBb vs. bb = 0.99, 95 % CI = 0.92-1.06, P = 0.992). In further stratified analyses by ethnicity and control source, no significant association was revealed. This study suggests that the -634G/C polymorphism does not appear to represent a risk factor for breast cancer.
authors.affiliation: Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Weirong
authors.initials: W
authors.lastname: Yao
authors.forename: Rongzeng
authors.initials: R
authors.lastname: Yan
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Huiping
authors.initials: H
authors.lastname: Wan
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Yu
authors.forename: Xia
authors.initials: X
authors.lastname: Cheng
authors.forename: Yingliang
authors.initials: Y
authors.lastname: Li
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A