title: Network dysfunction in Alzheimer's disease: refining the disconnection hypothesis.
abstract: Much effort in recent years has focused on understanding the effects of Alzheimer's disease (AD) on neural function. This effort has resulted in an enormous number of papers describing different facets of the functional derangement seen in AD. A particularly important tool for these investigations has been resting-state functional connectivity. Attempts to comprehensively synthesize resting-state functional connectivity results have focused on the potential utility of functional connectivity as a biomarker for disease risk, disease staging, or prognosis. While these are all appropriate uses of this technique, the purpose of this review is to examine how functional connectivity disruptions inform our understanding of AD pathophysiology. Here, we examine the rationale and methodological considerations behind functional connectivity studies and then provide a critical review of the existing literature. In conclusion, we propose a hypothesis regarding the development and spread of functional connectivity deficits seen in AD.
authors.affiliation: 1 Program in Neuroscience, Division of Biological and Biomedical Science, School of Medicine, Washington University in St. Louis , St. Louis, Missouri.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Brier
authors.forename: Jewell B
authors.initials: JB
authors.lastname: Thomas
authors.forename: Beau M
authors.initials: BM
authors.lastname: Ances
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009415:Nerve Net / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods
keywords: Alzheimer's disease; brain networks; resting-state functional connectivity