title: The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide.
abstract: A rationally designed small-molecule fluorogenic probe for nitric oxide (NO) detection based on a new switching mechanism has been developed. Attaching a NO-responsive dihydropyridine pendant group to a fluorophore led to a probe that displays a very high sensitivity to NO concentrations down to the low nM range and a very high specificity to NO while being insensitive to other oxidative oxygen/nitrogen species that often interfere with the sensing of NO.
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China. minfeng_li@bnu.edu.cn.
authors.forename: Sufang
authors.initials: S
authors.lastname: Ma
authors.forename: De-Cai
authors.initials: DC
authors.lastname: Fang
authors.forename: Baoming
authors.initials: B
authors.lastname: Ning
authors.forename: Minfeng
authors.initials: M
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: He
authors.forename: Bing
authors.initials: B
authors.lastname: Gong
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D004095:Dihydropyridines / Q000737:chemistry; D004579:Electron Transport; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008856:Microscopy, Fluorescence; D009525:Niacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009569:Nitric Oxide / Q000032:analysis*; D026361:Reactive Nitrogen Species / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D003374:Coumarins; D004095:Dihydropyridines; D005456:Fluorescent Dyes; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D009525:Niacin; D009569:Nitric Oxide; C038806:1,4-dihydropyridine