title: Size controlled hydroxyapatite and calcium carbonate particles: synthesis and their application as templates for SERS platform.
abstract: An elegant route for hydroxyapatite (HA) particle synthesis via ionic exchange reaction is reported. Calcium carbonate particles (CaCO3) were recrystallized into HA beads in water solution with phosphate ions. The size of initial CaCO3 particles was controlled upon the synthesis by varying the amount of ethylene glycol (EG) in aqueous solution. The average size of HA beads ranged from 0.6±0.1 to 4.3±1.1μm. Silver nanoparticles were deposited on the surface of HA and CaCO3 particles via silver mirror reaction. Surface enhanced Raman scattering of silver functionalized beads was demonstrated by detecting Rhodamine B. CaCO3 and HA particles have a great potential for design of carrier which can provide diagnostic and therapeutic functions.
authors.affiliation: Department of Physics, University of Trento, 38122 Trento, Italy; A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia. Electronic address: bogdan.parakhonskiy@gmail.com.
authors.forename: B V
authors.initials: BV
authors.lastname: Parakhonskiy
authors.affiliation: Department of Physics, University of Trento, 38122 Trento, Italy; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Svenskaya
authors.affiliation: Max Plank Institute of Colloids and Interfaces, Potsdam, Germany.
authors.forename: A М
authors.initials: AМ
authors.lastname: Yashchenok
authors.affiliation: Faculty of Nano- and Biomedical Technologies, Saratov State University, 410012 Saratov, Russia.
authors.forename: H A
authors.initials: HA
authors.lastname: Fattah
authors.affiliation: Faculty of Nano- and Biomedical Technologies, Saratov State University, 410012 Saratov, Russia; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Inozemtseva
authors.affiliation: Healthcare Research and Innovation Program (IRCS), Bruno Kessler Foundation, 38122 Trento, Italy; Department of Industrial Engineering, University of Trento, 38122 Trento, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tessarolo
authors.affiliation: Department of Physics, University of Trento, 38122 Trento, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Antolini
authors.affiliation: Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia; Faculty of Nano- and Biomedical Technologies, Saratov State University, 410012 Saratov, Russia. Electronic address: gorinda@mail.ru.
authors.forename: D A
authors.initials: DA
authors.lastname: Gorin
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D019855:Ethylene Glycol / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012235:Rhodamines / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D014961:X-Ray Diffraction
chemical_list: D012235:Rhodamines; D017886:Durapatite; D019855:Ethylene Glycol; D002119:Calcium Carbonate; C029773:rhodamine B
keywords: Calcium carbonate; Hydroxyapatite; Particles; SERS; Silver nanoparticles; Vaterite