title: The impact of ethanol lock therapy on length of stay and catheter salvage in pediatric catheter-associated bloodstream infection.
abstract: BACKGROUND
  Ethanol lock therapy (ELT) with systemic antimicrobial therapy (SAT) is a treatment for catheter-associated bloodstream infections (CABSI). However, its impact on hospital length of stay (LOS) is unknown.
  
  
  OBJECTIVE
  Assess the impact of ELT on LOS, LOS attributable to CABSI (ALOS), and catheter salvage in pediatric hematology, oncology, stem cell transplant (HOSCT) CABSI.
  
  
  METHODS
  Retrospective review of HOSCT CABSI from January 2009 to July 2011.
  
  
  RESULTS
  A total of 124 CABSI episodes were reviewed in 66 patients. Mean LOS with ELT after 1 positive blood culture (BC) was 7.1 versus 12.3 days after ≥2 positive BC (P = .014). Mean ALOS was 1.6 days with ELT versus 2.9 days without ELT (P = .018). Mean ALOS with ELT after 1 positive BC was 3.75 days versus 5.8 days after ≥2 positive BC (P = .022). Catheter salvage rate: 41 of 48 (85%) with ELT versus 49 of 68 (72%) without ELT (P = .169).
  
  
  CONCLUSIONS
  Earlier initiation of ELT may decrease ALOS.
authors.affiliation: Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, USA.
authors.forename: Manu
authors.initials: M
authors.lastname: Chaudhary
authors.affiliation: Quaid-e-Azam Medical College, Bahawalpur, Pakistan.
authors.forename: Muhammad Fawad
authors.initials: MF
authors.lastname: Bilal
authors.affiliation: Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.affiliation: Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, USA.
authors.forename: Roland
authors.initials: R
authors.lastname: Chu
authors.affiliation: Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, USA.
authors.forename: Madhvi
authors.initials: M
authors.lastname: Rajpurkar
authors.affiliation: Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, USA emcgrath@med.wayne.edu.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: McGrath
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D016470:Bacteremia / Q000188:drug therapy* / Q000209:etiology; D055499:Catheter-Related Infections / Q000150:complications* / Q000188:drug therapy*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects; D015331:Cohort Studies; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D008824:Michigan; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000431:Ethanol
keywords: bloodstream infection; catheter infection; ethanol lock; pediatrics