title: Combined administration of oxycodone/naloxone in chronic osteo-articular diseases pain therapy.
abstract: The aim of this study is the analysis of the beneficial impact of using opioid receptor antagonist associated to opioid analgesic on the quality of life in patients suffering from chronic non-cancer pain. We recruited 60 patients suffering from osteo-articular diseases who were randomized into two groups of treatment. The group A was treated with the association of opioid receptor antagonist and opioid agonist, represented by Oxycodone. The group B was treated with the opioid analgesics Oxycodone, transdermal Fentanil, and Hidromorphone, without the opioid antagonist. The end-points assessed were the duration of titration, the average reached dosage, the duration of the stability of dosage and the opioid-induced constipation (OIC) using the BFI.
authors.affiliation: Department of Anesthesia, Rianimation, Intensive Therapy and Pain Therapy University "Federico II" Naples , Italy.
authors.forename: Palomba
authors.initials: P
authors.lastname: Rosa
authors.affiliation: Department of Anesthesia, Rianimation, Intensive Therapy and Pain Therapy University "Federico II" Naples , Italy.
authors.forename: Miralto
authors.initials: M
authors.lastname: Federica
authors.affiliation: Department of Anesthesia, Rianimation, Intensive Therapy and Pain Therapy University "Federico II" Naples , Italy.
authors.forename: Vinciguerra
authors.initials: V
authors.lastname: Annamaria
authors.affiliation: Department of Anesthesia, Rianimation, Intensive Therapy and Pain Therapy University "Federico II" Naples , Italy.
authors.forename: Salvato
authors.initials: S
authors.lastname: Fabiana
authors.affiliation: Department of Anesthesia, Rianimation, Intensive Therapy and Pain Therapy University "Federico II" Naples , Italy.
authors.forename: Vaccarella
authors.initials: V
authors.lastname: Anna
keywords: chronic osteo-articular diseases; chronic pain; oxycodone/naloxone