title: Mast cell activation disorders.
abstract: Disorders associated with mast cell activation range from relatively common IgE-mediated disease and chronic urticaria to rarer conditions such as mastocytosis or monoclonal mast cell activation disorder. Mast cell activation disorders can be mechanistically classified into primary (associated with abnormal production of mast cells that carry pathologic markers of clonality), secondary (normal mast cells activated in reaction to a microenvironmental trigger), and idiopathic (no etiology is found). Clinical presentations, diagnostic criteria as well as general principles of a stepwise therapy approach are discussed.
authors.affiliation: Mastocytosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: cakin@partners.org.
authors.forename: Cem
authors.initials: C
authors.lastname: Akin
mesh_terms: D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008415:Mastocytosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D005938:Glucocorticoids; D006633:Histamine Antagonists; D007155:Immunologic Factors
keywords: Diagnosis; Mast cell activation syndromes; Mast cells; Mastocytosis; Treatment; Tryptase c-kit