title: 1-Acetylpyrene-salicylic acid: photoresponsive fluorescent organic nanoparticles for the regulated release of a natural antimicrobial compound, salicylic acid.
abstract: Photoresponsive 1-acetylpyrene-salicylic acid (AcPy-SA) nanoparticles (NPs) were developed for the regulated release of a natural antimicrobial compound, salicylic acid. The strong fluorescent properties of AcPy-SA NPs have been extensively used for potential in vitro cell imaging. The phototrigger capability of our newly prepared AcPy-SA NPs was utilized for the efficient release of an antimicrobial compound, salicylic acid. The photoregulated drug release of AcPy-SA NPs has been shown by the subsequent switching off and on of a visible-light source. In vitro biological studies reveal that AcPy-SA NPs of ∼68 nm size deliver the antimicrobial drug salicylic acid into the bacteria cells (Pseudomonas aeruginosa) and efficiently kill the cells upon exposure to visible light (≥410 nm). Such photoresponsive fluorescent organic NPs will be highly beneficial for targeted and regulated antimicrobial drug release because of their biocompatible nature, efficient cellular uptake, and light-induced drug release ability.
authors.affiliation: Department of Chemistry and ‡Department of Biotechnology, Indian Institute of Technology Kharagpur 721302, West Bengal India.
authors.forename: Shrabani
authors.initials: S
authors.lastname: Barman
authors.forename: Sourav K
authors.initials: SK
authors.lastname: Mukhopadhyay
authors.forename: Krishna Kalyani
authors.initials: KK
authors.lastname: Behara
authors.forename: Satyahari
authors.initials: S
authors.lastname: Dey
authors.forename: N D Pradeep
authors.initials: ND
authors.lastname: Singh
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D005456:Fluorescent Dyes / Q000737:chemistry; D008027:Light; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D010782:Photolysis; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011721:Pyrenes / Q000737:chemistry*; D020156:Salicylic Acid / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D005456:Fluorescent Dyes; D011721:Pyrenes; C030984:pyrene; D020156:Salicylic Acid