title: No additional benefit with use of a fibrin sealant to decrease peri-operative blood loss during primary total knee arthroplasty.
abstract: Blood loss remains a substantial problem associated TKA. This study evaluated the efficacy of a fibrin sealant on: (1) blood loss; (2) blood transfusions; and (3) length of stay. We evaluated the records of 113 consecutive patients with sealant and 70 without sealant. There was no significant difference in the hemoglobin levels (all 9.5-10 g/dL) on each of three postoperative days. There was also no significant difference in the intraoperative blood loss, postoperative blood loss or the total perioperative blood loss in both groups. The mean requirement in each patient was 2.5 ± 2.4 units in the fibrin sealant group compared to 2.0 ± 0.8 units in the non-fibrin sealant group. We have stopped using fibrin sealant based on this study.
authors.affiliation: SUNY Downstate Medical Center Department of Orthopaedic Surgery and Rehabilitation, Brooklyn, New York.
authors.forename: Aditya V
authors.initials: AV
authors.lastname: Maheshwari
authors.affiliation: SUNY Downstate Medical Center Department of Orthopaedic Surgery and Rehabilitation, Brooklyn, New York.
authors.forename: Yevgeiny
authors.initials: Y
authors.lastname: Korshunov
authors.affiliation: SUNY Downstate Medical Center Department of Orthopaedic Surgery and Rehabilitation, Brooklyn, New York.
authors.forename: Qais
authors.initials: Q
authors.lastname: Naziri
authors.affiliation: SUNY Downstate Medical Center Department of Orthopaedic Surgery and Rehabilitation, Brooklyn, New York.
authors.forename: Robert
authors.initials: R
authors.lastname: Pivec
authors.affiliation: Rubin Institute for Advanced Orthopedics Center for Joint Preservation and Replacement Sinai Hospital of Baltimore Baltimore, Maryland.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mont
authors.affiliation: SUNY Downstate Medical Center Department of Orthopaedic Surgery and Rehabilitation, Brooklyn, New York.
authors.forename: Vijay J
authors.initials: VJ
authors.lastname: Rasquinha
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D015718:Fibrin Tissue Adhesive; D006454:Hemoglobins; D006490:Hemostatics
keywords: fibrin sealant; hemostasis; total knee