title: Familial mediterranean Fever: diagnosing as early as 3 months of age.
abstract: Familial Mediterranean Fever is an autosomal recessive disease. Major symptoms of disease are recurrent fever accompanied by serositis attacks. The disease is usually diagnosed before 20 years of age. Symptoms related to FMF are noted when children become more verbal, usually after 2 years of age. In this case report, the youngest patient with the diagnosis of FMF is presented. She was consulted to pediatric rheumatology for the high acute phase response and fever. It was learned that her mother had recurrent swelling of her ankle joints. Mutation analysis was performed and two homozygous mutations (M694V and R202Q) were identified. She was diagnosed as FMF at 3 months of age and colchicine was started. She responded to colchicine. Her uncontrolled acute phase response declined gradually. This case was reported to point out the importance of early remembrance of autoinflammatory diseases even at very early ages especially at endemic countries.
authors.affiliation: İstanbul Kanuni Sultan Süleyman Educational and Research Hospital, 34303 İstanbul, Turkey.
authors.forename: Gonca
authors.identifier: 0000-0003-1797-2802
authors.initials: G
authors.lastname: Keskindemirci
authors.affiliation: İstanbul Kanuni Sultan Süleyman Educational and Research Hospital, 34303 İstanbul, Turkey.
authors.forename: Nuray
authors.identifier: 0000-0003-3594-7387
authors.initials: N
authors.lastname: Aktay Ayaz
authors.affiliation: İstanbul Kanuni Sultan Süleyman Educational and Research Hospital, 34303 İstanbul, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Aldemir
authors.affiliation: İstanbul Kanuni Sultan Süleyman Educational and Research Hospital, 34303 İstanbul, Turkey.
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Aydoğmuş
authors.affiliation: İstanbul Kanuni Sultan Süleyman Educational and Research Hospital, 34303 İstanbul, Turkey.
authors.forename: Gönül
authors.initials: G
authors.lastname: Aydoğan
authors.affiliation: İstanbul Kanuni Sultan Süleyman Educational and Research Hospital, 34303 İstanbul, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Kavuncuoğlu