title: Clinically relevant pharmacogenomic testing in pediatric practice.
abstract: Clinicians and patients continue to convey interest in personalized medicine. The objective of personalized medicine is to improve healthcare by tailoring disease prevention, diagnosis, and treatment strategies for individuals based on their unique clinical history and genetic composition. This article offers an overview of pharmacogenomics, discusses caveats specific to pharmacogenomics in pediatric populations, provides evidence-based recommendations for pediatric clinicians, and offers insight regarding the future role of pharmacogenomics testing in pediatric medicine. Reviews of the current literature and thoughtful discussions are presented regarding the pharmacogenomics of antidepressants, codeine and oncologic, asthma, and immunomodulatory pharmacotherapies.
authors.affiliation: The Ohio State University College of Medicine, Columbus, OH, USA lindsey.korbel@osumc.edu.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Korbel
authors.affiliation: St Barnabas Hospital, Bronx, NY, USA.
authors.forename: Mathew
authors.initials: M
authors.lastname: George
authors.affiliation: The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kitzmiller
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy / Q000235:genetics; D002648:Child; D003061:Codeine / Q000494:pharmacology; D019389:Cytochrome P-450 CYP2D6 / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D015122:Mercaptopurine / Q000494:pharmacology*; D008727:Methotrexate / Q000494:pharmacology*; D010372:Pediatrics; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D016559:Tacrolimus / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D007155:Immunologic Factors; D015122:Mercaptopurine; D019389:Cytochrome P-450 CYP2D6; D003061:Codeine; D016559:Tacrolimus; D008727:Methotrexate
keywords: genetics; pediatrics; pharmacogenomics; pharmacotherapy