title: Correlated inflammatory responses and neurodegeneration in peptide-injected animal models of Alzheimer's disease.
abstract: Animal models of Alzheimer's disease (AD) which emphasize activation of microglia may have particular utility in correlating proinflammatory activity with neurodegeneration. This paper reviews injection of amyloid- β (A β ) into rat brain as an alternative AD animal model to the use of transgenic animals. In particular, intrahippocampal injection of Aβ 1-42 peptide demonstrates prominent microglial mobilization and activation accompanied by a significant loss of granule cell neurons. Furthermore, pharmacological inhibition of inflammatory reactivity is demonstrated by a broad spectrum of drugs with a common endpoint in conferring neuroprotection in peptide-injected animals. Peptide-injection models provide a focus on glial cell responses to direct peptide injection in rat brain and offer advantages in the study of the mechanisms underlying neuroinflammation in AD brain.
authors.affiliation: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada V6T 1W3.
authors.forename: James G
authors.initials: JG
authors.lastname: McLarnon
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D000818:Animals; D001921:Brain / Q000276:immunology / Q000503:physiopathology; D001923:Brain Chemistry; D004195:Disease Models, Animal; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides