title: The use of high-dose hydroxocobalamin for vasoplegic syndrome.
abstract: We describe a case of hypotension on cardiopulmonary bypass for coronary artery bypass grafting, double valve repairs, and patent foramen ovale closure. The patient experienced vasoplegic syndrome while on cardiopulmonary bypass. He was treated with high-dose hydroxocobalamin (vitamin B12). His blood pressure responded rapidly, obviating any further vasopressor requirements.
authors.affiliation: Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia. Electronic address: roderiquejd@vcu.edu.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Roderique
authors.affiliation: Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia.
authors.forename: Kofi
authors.initials: K
authors.lastname: VanDyck
authors.affiliation: Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia.
authors.forename: Brita
authors.initials: B
authors.lastname: Holman
authors.affiliation: Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Tang
authors.affiliation: Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia.
authors.forename: Betty
authors.initials: B
authors.lastname: Chui
authors.affiliation: Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Spiess
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods; D054092:Foramen Ovale, Patent / Q000601:surgery; D006349:Heart Valve Diseases / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use*; D007431:Intraoperative Complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome; D056987:Vasoplegia / Q000188:drug therapy* / Q000209:etiology
chemical_list: D006879:Hydroxocobalamin