title: Frequency and predictors of normalization of left ventricular ejection fraction in recent-onset nonischemic cardiomyopathy.
abstract: Emerging evidence has shown the potential of marked improvement in left ventricular ejection fraction (LVEF) in patients with recent-onset cardiomyopathy (ROCM) on medical therapy. This study was designed to determine the frequency and to identify predictors of normalization of LVEF in a cohort of Chinese patients with ROCM receiving contemporary medication. A consecutive series of patients admitted from October 2008 to November 2012 with the clinical diagnosis of ROCM and LVEF ≤ 40% by echocardiography at presentation were followed up at least 12 months to identify those with normalization of LVEF, defined as an increase in LVEF to a final level of ≥ 50%. An array of clinical and echocardiographic variables regarded as potentially relevant to normalization was evaluated to identify predictors using logistic regression analysis. After a mean follow-up of 31 ± 13 months, 48% of 128 patients had normalized their LVEF, showing a significant increase in LVEF from 32 ± 6% to 58 ± 5%, of which 68% occurred within 1 year after initial diagnosis. Multivariate analysis demonstrated that normalization of LVEF was associated with a history of hypertension, higher systolic blood pressure at presentation, shorter electrocardiographic QRS duration, smaller left ventricular end-diastolic diameter, and higher LVEF by echocardiography at baseline. In conclusion, nearly 1/2 of a relatively large number of Chinese patients with ROCM have shown normalization of LVEF on current medical therapy after a medium-term follow-up, which was associated with some clinical and echocardiographic parameters.
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Chang-hong
authors.initials: CH
authors.lastname: Zou
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China. Electronic address: fwzhangjian62@126.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Yu-hui
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Bing-qi
authors.initials: BQ
authors.lastname: Wei
authors.affiliation: Department of Internal Medicine, Beijing Water Conservancy Hospital, Beijing, China.
authors.forename: Xue-fei
authors.initials: XF
authors.lastname: Wu
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Rong-cheng
authors.initials: RC
authors.lastname: Zhang
authors.affiliation: Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Beijing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lv
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002681:China; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011379:Prognosis; D020127:Recovery of Function; D012189:Retrospective Studies; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*