title: Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.
abstract: Chemotherapy-induced hand-foot syndrome and nail changes are common complications of many classic chemotherapeutic agents and the newer molecular targeted therapies. They significantly impact patient quality of life, and frequently necessitate chemotherapy dose intensity modification or reduction. We aim to describe the epidemiology, pathogenesis, clinical presentation, and current evidence-based treatment options for these entities.
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
authors.forename: Kristen K
authors.initials: KK
authors.lastname: Miller
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
authors.forename: Loren
authors.initials: L
authors.lastname: Gorcey
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York. Electronic address: bethnmclellan@gmail.com.
authors.forename: Beth N
authors.initials: BN
authors.lastname: McLellan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D005260:Female; D060831:Hand-Foot Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: chemotherapy complications; chemotherapy nail complications; hand-foot skin reaction; hand-foot syndrome; molecular targeted therapy complications; palmoplantar erythrodysesthesia