title: The FGA Thr312Ala polymorphism and risk of intracerebral haemorrhage in Polish and Greek populations.
abstract: OBJECTIVE
  Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and mostly undiscovered effect on the brain haemorrhage risk. Since the coagulation system is crucial to ICH pathology, we studied the significance of the FGA Thr312Ala polymorphism in two European populations.
  
  
  METHODS
  We genotyped 550 and 224 controls as well as 261 and 242 stroke patients in Polish and Greek populations, respectively. The ICH diagnosis was confirmed by computed tomography. The FGA Thr312Ala polymorphism was analysed using real-time polymorphism chain reaction.
  
  
  RESULTS
  Both crude and multivariable regression analyses showed that the studied polymorphism is a protective factor in the Polish population under the dominant and additive models of inheritance. Those results did not replicate in the Greek population. The meta-analysis of results from the Polish and the Greek populations proved that FGA Thr312Ala polymorphism affects the risk of ICH in the dominant model of inheritance.
  
  
  CONCLUSIONS
  The FGA Thr312Ala polymorphism affects a risk for ICH in the Polish but not in the Greek population. An advanced meta-analysis of well-designed studies with a significant number of cases might provide useful information of novel polymorphisms, including the FGA Thr312Ala polymorphism, and their role in ICH pathology.
authors.affiliation: Department of Neurology, The University Hospital in Krakow, Krakow, Poland. Electronic address: jeremiasz.jagiella@gmail.com.
authors.forename: Jeremiasz
authors.initials: J
authors.lastname: Jagiełła
authors.affiliation: Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Efthimios
authors.initials: E
authors.lastname: Dardiotis
authors.affiliation: Chair of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gąsowski
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Pera
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Klimkowicz-Mrowiec
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Golenia
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Wnuk
authors.affiliation: Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Kostas
authors.initials: K
authors.lastname: Fountas
authors.affiliation: Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Paterakis
authors.affiliation: Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Hadjigeorgiou
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Słowik
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic / Q000235:genetics; D012044:Regression Analysis; D012306:Risk; D020521:Stroke / Q000235:genetics*
chemical_list: C464794:fibrinogen Aalpha; D005340:Fibrinogen
keywords: Brain haemorrhage; FGA Thr312Ala; Haemorrhagic stroke; Intracerebral haemorrhage