title: The first non-African case of Trichophyton rubrum var. raubitschekii or a urease-positive Trichophyton rubrum in Central Europe?
abstract: We report a case of a 34-year-old Polish Caucasian male who was diagnosed with tinea manuum caused by Trichophyton rubrum var. raubitschekii. It would be the first described case of a dermatophytosis caused by this fungus in Poland and one of a few cases in Central Europe described so far. Admittedly, it would be the first case in Central Europe with no evidence pointing to African origin. The clinical condition improved after administering itraconazole (daily dose 100 mg orally) supplemented with a topical treatment, while the patient was totally cured after 2 months. The histopathological examination turned out to be highly useful in the diagnostic process. The genetic analysis of the urease gene pointed to a urease-positive T. rubrum rather than T. rubrum var. raubitschekii.
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Adamski
authors.forename: Michał J
authors.initials: MJ
authors.lastname: Kowalczyk
authors.forename: Kinga
authors.initials: K
authors.lastname: Adamska
authors.forename: Honorata
authors.initials: H
authors.lastname: Kubisiak-Rzepczyk
authors.forename: Monika
authors.initials: M
authors.lastname: Bowszyc-Dmochowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Banaszak
authors.forename: Paweł
authors.initials: P
authors.lastname: Bartkiewicz
authors.forename: Ryszard
authors.initials: R
authors.lastname: Zaba
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D020459:Genes, rRNA; D006225:Hand / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D011044:Poland; D012331:RNA, Fungal / Q000235:genetics; D012339:RNA, Ribosomal, 28S / Q000235:genetics; D017422:Sequence Analysis, DNA; D014005:Tinea / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D016896:Treatment Outcome; D014249:Trichophyton / Q000145:classification* / Q000201:enzymology / Q000302:isolation & purification*; D014510:Urease / Q000235:genetics / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer; D012331:RNA, Fungal; D012339:RNA, Ribosomal, 28S; D017964:Itraconazole; D014510:Urease