title: Correlation of salivary alpha amylase level and adenotonsillar hypertrophy with sleep disordered breathing in pediatric subjects.
abstract: OBJECTIVE
  Obstructive sleep apnea syndrome (OSAS) and sleep disordered breathing (SDB) can affect the sympathetic adrenomedullary system (SAM). As a biomarker of SAM activity, salivary α-amylase (sAA) in pediatric subjects was evaluated whether it has any correlation with polysomnographic (PSG) parameters related to SDB.
  
  
  METHODS
  Sixty-seven children who attended our clinic during 1 year were enrolled prospectively and underwent clinical examinations and in-lab polysomnography. The sAA was measured at 2 points--at night before PSG and in the early morning after PSG.
  
  
  RESULTS
  Subjects were divided into control (n = 26, apneahypopnea index [AHI] < 1) and OSAS (n = 41, AHI ≥ 1) groups. The OSAS group was subdivided according to AHI (mild-moderate, 1 ≤ AHI < 10; severe, AHI ≥ 10). The sAA subtraction and ratio (p = 0.014 and p < 0.001, respectively) were significantly higher in severe OSAS than in the mild-moderate and control groups. Although oxygen desaturation index (ODI) and AHI were significantly associated with sAA, sAA in the OSAS group was not related to lowest oxygen saturation or adenotonsillar hypertrophy.
  
  
  CONCLUSIONS
  sAA was well related to polysomnographic (PSG) parameters related to SDB, such as AHI and ODI. Therefore, screening test for sAA in children suspected to have SBD may help to identify OSAS patients from control.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Suwon St. Vincent's Hospital.
authors.forename: Chan-Soon
authors.initials: CS
authors.lastname: Park
authors.affiliation: Stanford University Sleep Medicine Division, Redwood City, CA.
authors.forename: Christian
authors.initials: C
authors.lastname: Guilleminault
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Suwon St. Vincent's Hospital.
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Yeouido St. Mary's Hospital.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Suwon St. Vincent's Hospital.
authors.forename: Heung-Ku
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Suwon St. Vincent's Hospital.
authors.forename: Hye-Lim
authors.initials: HL
authors.lastname: Son
authors.affiliation: Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Se-Hwan
authors.initials: SH
authors.lastname: Hwang
mesh_terms: D000234:Adenoids / Q000473:pathology*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology*; D017286:Polysomnography; D011446:Prospective Studies; D012463:Saliva / Q000201:enzymology*; D012891:Sleep Apnea Syndromes / Q000201:enzymology / Q000473:pathology*; D000516:alpha-Amylases / Q000032:analysis*
chemical_list: D000516:alpha-Amylases
keywords: amylase; child; polysomnography; saliva; sleep disordered breathing