title: Levels of soluble TNF-RII are increased in serum of patients with primary progressive multiple sclerosis.
abstract: The levels of soluble tumor necrosis factor receptor II (sTNF-RII) were determined in serum of 161 untreated multiple sclerosis (MS) patients with different clinical forms and 46 healthy controls (HC) by ELISA. Our results show that serum sTNF-RII levels were significantly increased in patients with primary progressive MS (PPMS) compared with other MS forms and HC. Although sTNF-RII levels significantly increased over a 2-year follow-up period in a subgroup of PPMS patients, they could not discriminate between patients with and without disability progression. Additional studies are needed to further implicate sTNF-RII in patients with PPMS.
authors.affiliation: Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain. Electronic address: nicolas.fissolo@vhir.org.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Fissolo
authors.affiliation: Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.
authors.forename: Ester
authors.initials: E
authors.lastname: Cantó
authors.affiliation: Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Vidal-Jordana
authors.affiliation: Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Castilló
authors.affiliation: Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Montalban
authors.affiliation: Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Comabella
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood*; D020529:Multiple Sclerosis, Relapsing-Remitting; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*
chemical_list: D047889:Receptors, Tumor Necrosis Factor, Type II
keywords: Disability progression; Primary progressive multiple sclerosis; Tumor necrosis factor receptor II