title: Co-expression of CD147 and GLUT-1 indicates radiation resistance and poor prognosis in cervical squamous cell carcinoma.
abstract: The aim of this study was to investigate the association of CD147 and GLUT-1, which play important roles in glycolysis in response to radiotherapy and clinical outcomes in patients with locally advanced cervical squamous cell carcinoma (LACSCC). The records of 132 female patients who received primary radiation therapy to treat LACSCC at FIGO stages IB-IVA were retrospectively reviewed. Forty-seven patients with PFS (progression-free survival) of less than 36 months were regarded as radiation-resistant. Eighty-five patients with PFS longer than 36 months were regarded as radiation-sensitive. Using pretreatment paraffin-embedded tissues, we evaluated CD147 and GLUT-1 expression by immunohistochemistry. Overexpression of CD147, GLUT-1, and CD147 and GLUT-1 combined were 44.7%, 52.9% and 36.5%, respectively, in the radiation-sensitive group, and 91.5%, 89.4% and 83.0%, respectively, in the radiation-resistant group. The 5-year progress free survival (PFS) rates in the CD147-low, CD147-high, GLUT-1-low, GLUT-1-high, CD147- and/or GLUT-1-low and CD147- and GLUT-1- dual high expression groups were 66.79%, 87.10%, 52.78%, 85.82%, 55.94%, 82.90% and 50.82%, respectively. CD147 and GLUT-1 co-expression, FIGO stage and tumor diameter were independent poor prognostic factors for patients with LACSCC in multivariate Cox regression analysis. Patients with high expression of CD147 alone, GLUT-1 alone or co-expression of CD147 and GLUT-1 showed greater resistance to radiotherapy and a shorter PFS than those with low expression. In particular, co-expression of CD147 and GLUT-1 can be considered as a negative independent prognostic factor.
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Xin-Qiong
authors.initials: XQ
authors.lastname: Huang
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Hunan Provincial Tumal Hospital & Affiliated Tumor Hospital of Xiangya Medical School, Central South University Hunan Province, P.R. China.
authors.forename: Xiao-Xue
authors.initials: XX
authors.lastname: Xie
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Liang-Fang
authors.initials: LF
authors.lastname: Shen
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University Hunan Province, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051926:Basigin / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000532:radiotherapy*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D051272:Glucose Transporter Type 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D017211:Treatment Failure; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000401:mortality / Q000532:radiotherapy*
chemical_list: C497886:BSG protein, human; D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; D051926:Basigin
keywords: CD147; GLUT-1; Radiation resistance; cervical carcinoma; glycolysis; immunohistochemistry