title: In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin.
abstract: The antimicrobial activity of one 3-hydroxypyridin-4-one (HPO) hexadentate (1) and three HPO hexadentate-based dendrimeric chelators (2-4) was evaluated. They were found to exhibit marked inhibitory effect on the growth of two Gram-positive bacteria and two Gram-negative bacteria. The combination treatment of dendrimeric chelator 2 with norfloxacin against Staphyloccocus aureus and Escherichia coli showed a dramatic synergistic bactericidal effect. As the dendrimeric chelator has a large molecular weight, its combination with norfloxacin may find application in the treatment of external infections.
authors.affiliation: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, China.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Zhang
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D011728:Pyridones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C121031:3-hydroxypyridin-4-one; D000890:Anti-Infective Agents; D002614:Chelating Agents; D011725:Pyridines; D011728:Pyridones; D009643:Norfloxacin
keywords: antimicrobial activity; dendrimer; hexadentate; hydroxypyridinone; iron chelator