title: Bioactivity evolution of the surface functionalized bioactive glasses.
abstract: The formation of a calcium phosphate layer on the surface of the SiO2 -CaO-P2 O5 glasses after immersion in simulated body fluid (SBF) generally demonstrates the bioactivity of these materials. Grafting of the surface by chemical bonding can minimize the structural changes in protein adsorbed on the surface. Therefore, in this study our interest was to evaluate the bioactivity and blood biocompatibility of the SiO2 -CaO-P2 O5 glasses after their surface modification by functionalization with aminopropyl-triethoxysilane and/or by fibrinogen. It is shown that the fibrinogen adsorbed on the glass surfaces induces a growing of the apatite-like layer. It is also evidenced that the protein content from SBF influences the growth of the apatite-like layer. Furthermore, the good blood compatibility of the materials after fibrinogen and bovine serum albumin adsorption is proved from the assessment of the β-sheet-β-turn ratio.
authors.affiliation: Faculty of Physics and Institute of Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400084, Cluj-Napoca, Romania.
authors.forename: Klára
authors.initials: K
authors.lastname: Magyari
authors.forename: Lucian
authors.initials: L
authors.lastname: Baia
authors.forename: Adriana
authors.initials: A
authors.lastname: Vulpoi
authors.forename: Simion
authors.initials: S
authors.lastname: Simon
authors.forename: Octavian
authors.initials: O
authors.lastname: Popescu
authors.forename: Viorica
authors.initials: V
authors.lastname: Simon
mesh_terms: D000818:Animals; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D011437:Propylamines; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D011437:Propylamines; D012821:Silanes; D012710:Serum Albumin, Bovine; D005340:Fibrinogen; C477625:amino-propyl-triethoxysilane
keywords: bioactive glasses; biological fluids; protein adsorption; protein conformation; surface modification