title: Bone marrow vascular niche: home for hematopoietic stem cells.
abstract: Though discovered later than osteoblastic niche, vascular niche has been regarded as an alternative indispensable niche operating regulation on hematopoietic stem cells (HSCs). As significant progresses gained on this type niche, it is gradually clear that the main work of vascular niche is undertaking to support hematopoiesis. However, compared to what have been defined in the mechanisms through which the osteoblastic niche regulates hematopoiesis, we know less in vascular niche. In this review, based on research data hitherto we will focus on component foundation and various functions of vascular niche that guarantee the normal hematopoiesis process within bone marrow microenvironments. And the possible pathways raised by various research results through which this environment undergoes its function will be discussed as well.
authors.affiliation: Department of Pathophysiology, Nankai University School of Medicine, 94 Weijin Road, Tianjin 300071, China ; The Key Laboratory of Bioactive Materials, The College of Life Science, Nankai University, Ministry of Education, Tianjin 300071, China.
authors.forename: Ningning
authors.initials: N
authors.lastname: He
authors.affiliation: Department of Pathophysiology, Nankai University School of Medicine, 94 Weijin Road, Tianjin 300071, China ; The Key Laboratory of Bioactive Materials, The College of Life Science, Nankai University, Ministry of Education, Tianjin 300071, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Intensive Care Unit (ICU), People's Hospital of Rizhao, Shandong 276826, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Pathophysiology, Nankai University School of Medicine, 94 Weijin Road, Tianjin 300071, China ; The Key Laboratory of Bioactive Materials, The College of Life Science, Nankai University, Ministry of Education, Tianjin 300071, China.
authors.forename: Zongjin
authors.initials: Z
authors.lastname: Li