title: Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China.
abstract: To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.
authors.affiliation: Qingdao Center for Disease Control and Prevention, Qingdao, 266033, Shandong, People's Republic of China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liu
authors.forename: Naiying
authors.initials: N
authors.lastname: Mao
authors.forename: Weisen
authors.initials: W
authors.lastname: Yu
authors.forename: Qing
authors.initials: Q
authors.lastname: Chai
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Wang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Wang
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000821:virology*; D004770:Enterovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D015678:Viral Structural Proteins