title: Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy.
abstract: Depending on tumor type, stage and immunological contexture, the inhibition of chemokines or their receptors may yield positive or deleterious effects on disease progression. We have recently demonstrated in several murine models of anthracycline-based chemotherapy that the inhibition of chemokine (C-C motif) ligand 2 (CCL2) or chemokine (C-C motif) receptor 2 (CCR2) may impair the elicitation of anticancer immune responses that contribute to therapeutic success.
authors.affiliation: Université Paris Descartes/Paris V; Sorbonne Paris Cité; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France ; Gustave Roussy Cancer Campus; Villejuif, France.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Gustave Roussy Cancer Campus; Villejuif, France ; INSERM, U848; Villejuif, France.
authors.forename: Sandy
authors.initials: S
authors.lastname: Adjemian
authors.affiliation: Université Paris Descartes/Paris V; Sorbonne Paris Cité; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France ; Gustave Roussy Cancer Campus; Villejuif, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: INSERM, U1015; Villejuif, France ; Faculté de Médecine; Université Paris-Saclay; Le Kremlin Bicêtre, France ; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507; Villejuif, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
authors.affiliation: Université Paris Descartes/Paris V; Sorbonne Paris Cité; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France ; INSERM, U848; Villejuif, France ; Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus; Villejuif, France ; Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP; Paris, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
keywords: ATP; autophagy; cancer stem cells; immunogenic cell death; immunosurveillance; γδ T lymphocytes