title: Cytoglobin in tumor hypoxia: novel insights into cancer suppression.
abstract: Emerging new and intriguing roles of cytoglobin (Cygb) have attracted considerable attention of cancer researchers in recent years. Hypoxic upregulation of Cygb as well as its altered expression in various human cancers suggest another possible role of this newly discovered globin in tumor cell response under low oxygen tension. Since tumor hypoxia is strongly associated with malignant progression of disease and poor treatment response, it constitutes an area of paramount importance for rational design of cancer selective therapies. However, the mechanisms involved during this process are still elusive. This review outlines the current understanding of Cygb's involvement in tumor hypoxia and discusses its role in tumorigenesis. A better perception of Cygb in tumor hypoxia response is likely to open novel perspectives for future tumor therapy.
authors.affiliation: Department of Biochemistry, University of Delhi South Campus, Benito Juarez Marg, New Delhi, 110021, India.
authors.forename: Sankalpa
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Rince
authors.initials: R
authors.lastname: John
authors.forename: Alo
authors.initials: A
authors.lastname: Nag
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D015687:Cell Hypoxia / Q000235:genetics; D000078842:Cytoglobin; D015972:Gene Expression Regulation, Neoplastic; D005914:Globins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D010100:Oxygen / Q000378:metabolism
chemical_list: C000627265:CYGB protein, human; D000078842:Cytoglobin; D005914:Globins; D010100:Oxygen