title: PTGER4 modulating variants in Crohn's disease.
abstract: OBJECTIVE
  Variants modulating expression of the prostaglandin receptor 4 (PTGER4) have been reported to be associated with Cohn's disease (CD), but the clinical impact remains to be elucidated. We analyzed these variants in a large German inflammatory bowel disease (IBD) cohort and searched for a potential phenotype association.
  
  
  METHODS
  The variants rs4495224 and rs7720838 were studied in adult German IBD patients (CD, n = 475; ulcerative colitis (UC), n = 293) and healthy controls (HC, n = 467). Data were correlated to results from NOD2 genotyping and to clinical characteristics.
  
  
  RESULTS
  We found a significant association for the rs7720838 variant with overrepresentation of the T allele to CD (p = 0.0058; OR 0.7703, 95 % CI 0.641-0.926) but not to UC. Furthermore, logistic regression analysis revealed that the presence of the T allele was associated with stricturing disease behavior in CD patients (p = 0.03; OR 1.84, 95 % CI 1.07-3.16). Interestingly, the chance for developing stricturing disease behavior was enhanced if mutant alleles in both rs7720838 and NOD2 were present (OR 2.87, 95 % CI 1.42-5.81; p = 0.003). No overall association to CD or UC was found for the rs4495224 variant.
  
  
  CONCLUSIONS
  The PTGER4 modulating variant rs7720838 increases susceptibility for CD and might resemble a risk factor for stricturing disease behavior.
authors.affiliation: Department of Hepatology and Gastroenterology, Universitätsmedizin Berlin, Charité Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Prager
authors.forename: Janine
authors.initials: J
authors.lastname: Büttner
authors.forename: Carsten
authors.initials: C
authors.lastname: Büning
mesh_terms: D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics; D003251:Constriction, Pathologic; D003424:Crohn Disease / Q000235:genetics*; D003710:Demography; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000235:genetics*
chemical_list: D053473:Nod2 Signaling Adaptor Protein; C545650:PTGER4 protein, human; D058309:Receptors, Prostaglandin E, EP4 Subtype