title: Paraneoplastic sclerodermiform syndrome--case report.
abstract: Occasionally, auto-immune diseases may emerge as paraneoplastic syndromes. This is especially recognized in the case of polymyositis/dermatomyostis, but it is an extremely rare event in systemic sclerosis (SSc). The authors report the case of a sixty-year-old woman who presented with Raynaud's phenomenon and rapidly progressing skin thickness of the forearms, hands and lower limbs. Patient evaluation revealed a colorectal carcinoma. The patient was referred to the oncology department. This concomitance of cancer and SSc with rapid progression of the latter, suggests that the scleroderma might have a paraneoplastic origin. Such an hypothesis deserves consideration in every case as early diagnosis may be decisive to control the progression of either disease.
authors.forename: João
authors.initials: J
authors.lastname: Rovisco
authors.forename: Sara
authors.initials: S
authors.lastname: Serra
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu
authors.forename: Margarida
authors.initials: M
authors.lastname: Coutinho
authors.forename: Tânia
authors.initials: T
authors.lastname: Santiago
authors.forename: Luís
authors.initials: L
authors.lastname: Inês
authors.forename: José António Pereira
authors.initials: JA
authors.lastname: da Silva
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D015179:Colorectal Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology*