title: Design, synthesis and biological evaluation of novel thiosemicarbazide analogues as potent anticonvulsant agents.
abstract: Novel thiosemicarbazide derivatives were synthesised and evaluated for their anticonvulsant activity and neurotoxicity. Anticonvulsant activity was done for grand mal and petit mal types of epilepsies by maximal electroshock (MES) and pentylenetetrazol (PTZ) induced convulsions methods respectively. Rotarod test was done to determine neurotoxicity. Amongst synthesised compounds, N-(4-bromophenyl)2-[(2-phenylhydrazinyl) carbonothioyl] hydrazinecarbothioamide (5e) is a broad-spectrum anticonvulsant agent since it was active in both (MES) and (PTZ) induced seizure models with no neurotoxicity and N,N-(bis(chlorophenyl)hydrazine-1,2-dicarbothoamide (5g) acts as a selective agent for grand mal epilepsy.
authors.affiliation: Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nashik 422403, Maharashtra, India. Electronic address: rjnevagi@gmail.com.
authors.forename: Reshma J
authors.initials: RJ
authors.lastname: Nevagi
authors.affiliation: Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nashik 422403, Maharashtra, India.
authors.forename: Avinash S
authors.initials: AS
authors.lastname: Dhake
authors.affiliation: Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nashik 422403, Maharashtra, India.
authors.forename: Harsha I
authors.initials: HI
authors.lastname: Narkhede
authors.affiliation: Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nashik 422403, Maharashtra, India.
authors.forename: Prabhjeet
authors.initials: P
authors.lastname: Kaur
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D004597:Electroshock; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000008:administration & dosage; D045442:Rotarod Performance Test; D012663:Semicarbazides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D012663:Semicarbazides; C005151:thiosemicarbazide; D010433:Pentylenetetrazole
keywords: Epilepsy; Grand mal; Neurotoxicity; Petit mal