title: Ketoprofen is more effective than diclofenac after oral surgery when used as a preemptive analgesic: a pilot study.
abstract: OBJECTIVE
  To evaluate the preemptive analgesia of ketoprofen in comparison with diclofenac after mandibular third molar surgery.
  
  
  METHODS
  This study was a double-blind, randomized clinical trial. Forty patients were randomized into two treatment groups (each with 20 patients) by using a series of random numbers: group A received ketoprofen 100 mg and group B received diclofenac 75 mg, all intramuscularly. Surgery was done 30 minutes after analgesic treatments. The durations of analgesia, pain intensity, analgesic consumption, and side effects were evaluated. The statistical analysis was done using the chi-square, Student t, Mann-Whitney U, and Log-Rank tests.
  
  
  RESULTS
  The duration of analgesia was longer in the ketoprofen group when compared with the diclofenac group. The number of patients taking the first rescue analgesic at 6 hours was lower in the ketoprofen group in comparison with the diclofenac group. Patients who received ketoprofen had lower pain intensity compared with patients who received diclofenac.
  
  
  CONCLUSIONS
  Intramuscular ketoprofen 100 mg is more effective than intramuscular diclofenac 75 mg after mandibular third molar extraction when used as a preemptive analgesic.
authors.forename: Grace Carolaine Esquivel
authors.initials: GC
authors.lastname: Velásquez
authors.forename: Luis A German
authors.initials: LA
authors.lastname: Santa Cruz
authors.forename: Mario Alberto Isiordia
authors.initials: MA
authors.lastname: Espinoza
mesh_terms: D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003002:Clonixin / Q000031:analogs & derivatives / Q000627:therapeutic use; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008239:Lysine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008334:Mandible / Q000601:surgery; D008964:Molar, Third / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010865:Pilot Projects; D011292:Premedication; D013997:Time Factors; D014081:Tooth Extraction / Q000379:methods*; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; C089163:lysine clonixinate; D004008:Diclofenac; D007660:Ketoprofen; D008239:Lysine; D003002:Clonixin