title: [Calcium-depended mechanism of the antiplatelet activity of benzimidazole derivative RU-891].
abstract: We have studied the effect of the new benzimidazole derivative RU-891, known to exhibit antiaggregant activity in vitro and in vivo, on the level of intracellular calcium ions in platelets of laboratory rabbits. Compound RU-891 was found to inhibit the thrombin-induced growth of intracellular calcium ion level in thrombocytes.This effect exceeded t he action o f reference d rugs and was not connected w ith the influence of RU-891 o n the potential-dependent c alci u m channels.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheriavenko
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D061207:Calcium Ionophores / Q000494:pharmacology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: C583978:9-(2-(3,4-dihydroxydiphenyl)-2-oxoethyl)-2,3-dihydroimidazo(1,2-a)benzimidazole; D001562:Benzimidazoles; D015220:Calcium Channels; D061207:Calcium Ionophores; D010975:Platelet Aggregation Inhibitors; D000001:Calcimycin; D013917:Thrombin; D002118:Calcium