title: SMC complexes link gene expression and genome architecture.
abstract: The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.
authors.affiliation: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Dowen
authors.affiliation: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: young@wi.mit.edu.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Young
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics*; D015870:Gene Expression; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D009154:Mutation; D014158:Transcription, Genetic