title: Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches.
abstract: Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old. The molecular and cellular alterations that trigger this disease are still diffuse, one of the reasons for the delay in finding an effective treatment. In the search for new targets to search for novel therapeutic avenues, clinical studies in patients who used anti-inflammatory drugs indicating a lower incidence of AD have been of value to support the neuroinflammatory hypothesis of the neurodegenerative processes and the role of innate immunity in this disease. Neuroinflammation appears to occur as a consequence of a series of damage signals, including trauma, infection, oxidative agents, redox iron, oligomers of τ and β-amyloid, etc. In this context, our theory of Neuroimmunomodulation focus on the link between neuronal damage and brain inflammatory process, mediated by the progressive activation of astrocytes and microglial cells with the consequent overproduction of proinflammatory agents. Here, we discuss about the role of microglial and astrocytic cells, the principal agents in neuroinflammation process, in the development of neurodegenerative diseases such as AD. In this context, we also evaluated the potential relevance of natural anti-inflammatory components, which include curcumin and the novel Andean Compound, as agents for AD prevention and as a coadjuvant for AD treatments.
authors.affiliation: Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile Santiago, Chile ; International Center for Biomedicine (ICC) Santiago, Chile.
authors.forename: Inelia
authors.initials: I
authors.lastname: Morales
authors.affiliation: Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile Santiago, Chile ; International Center for Biomedicine (ICC) Santiago, Chile.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Guzmán-Martínez
authors.affiliation: Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile Santiago, Chile ; International Center for Biomedicine (ICC) Santiago, Chile.
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Cerda-Troncoso
authors.affiliation: Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile Santiago, Chile ; International Center for Biomedicine (ICC) Santiago, Chile ; Department of Neurology and Neurosurgery North, Faculty of Medicine, University of Chile Santiago, Chile.
authors.forename: Gonzalo A
authors.initials: GA
authors.lastname: Farías
authors.affiliation: Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile Santiago, Chile ; International Center for Biomedicine (ICC) Santiago, Chile ; Department of Neurological Sciences East, Faculty of Medicine, University of Chile Santiago, Chile.
authors.forename: Ricardo B
authors.initials: RB
authors.lastname: Maccioni
keywords: Alzheimer disease; astrocytes; microglia; neuroinflammation; nutraceuticals