title: Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.
abstract: Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera.
authors.affiliation: Université François Rabelais, Virologie Immunologie Moléculaires, Tours, France; INRA UMR 1282, Infectiologie et Santé Publique, Tours, France.
authors.forename: Jérôme T J
authors.initials: JT
authors.lastname: Nicol
authors.affiliation: Université François Rabelais, Virologie Immunologie Moléculaires, Tours, France; INRA UMR 1282, Infectiologie et Santé Publique, Tours, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Liais
authors.affiliation: Association Beauval Nature pour la Conservation et la Recherche, Saint Aignan sur Cher, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Potier
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine, School of Medicine, University of Ferrara, Ferrara, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Mazzoni
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine, School of Medicine, University of Ferrara, Ferrara, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Tognon
authors.affiliation: Université François Rabelais, Virologie Immunologie Moléculaires, Tours, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Coursaget
authors.affiliation: Université François Rabelais, Virologie Immunologie Moléculaires, Tours, France; INRA UMR 1282, Infectiologie et Santé Publique, Tours, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Touzé
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D016000:Cluster Analysis; D019295:Computational Biology; D003429:Cross Reactions / Q000276:immunology*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008854:Microscopy, Electron; D002679:Pan troglodytes / Q000821:virology*; D010802:Phylogeny; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology*; D027601:Polyomavirus Infections / Q000453:epidemiology*; D016036:Seroepidemiologic Studies; D014771:Virion / Q000648:ultrastructure
chemical_list: D036022:Capsid Proteins; C062481:VP1 protein, polyomavirus