title: [Study on preparation and in vitro characteristics of ginsenoside Rg3 binary solid dispersion].
abstract: With low molecular weight chitosan and poloxamer 188 as the joint carriers, ginsenoside Rg3 solid dispersions were prepared by using the solvent evaporation method for an in vitro dissolution test. Subsequently, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray diffraction (X-RD) were adopted for a phase analysis. The results showed that the 60 min in vitro cumulative dissolution rate of ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 at the ratio of 2:1 exceeded 90%, and the drug was dispersed in carriers in an amorphous state. Therefore, ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 could help significantly improve the drug dissolution, with a practical application value.
authors.forename: Qi-Yuan
authors.initials: QY
authors.lastname: Liu
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Yu
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D048271:Chitosan / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D036145:Ginsenosides / Q000737:chemistry*; D008970:Molecular Weight; D020442:Poloxamer / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D036145:Ginsenosides; D012997:Solvents; D020442:Poloxamer; C097367:ginsenoside Rg3; D048271:Chitosan