title: [Pregabalin combined with intrathecal sufentanil infusion for breakthrough pain in patients with bone metastases].
abstract: OBJECTIVE
  To evaluate the analgesic effect of pregabalin combined with intrathecal sufentanil infusion for the treatment of breakthrough pain in patients with bone metastases.
  
  
  METHODS
  A total of 60 breakthrough pain patients with bone metastases were randomly divided to 3 groups: group A (pregabalin combined with intrathecal sufentanil infusion group, n=20), group B (placebo combined with intrathecal sufentanil infusion group, n=20) and group C (oral morphine sulfate controlled-release tablet group, n=20). The differences in visual analogue scale (VAS) between background pain and breakthrough pain, the seizure frequency of breakthrough pain, general satisfaction and side effects of the 3 groups were observed.
  
  
  RESULTS
  The seizure frequency and VAS of breakthrough pain in group A decreased significantly after the treatment (P<0.05) and the general satisfaction was the best among the the 3 groups (P<0.05), with less nausea and vomiting, constipation, drowsiness and fewer other side effects.
  
  
  CONCLUSIONS
  Pregabalin combined with intrathecal sufentanil infusion can effectively relieve breakthrough pain in patients with bone metastases.
authors.affiliation: Department of Pain Medicine, Mawangdui Hospital of Hunan, University of South China, Changsha 410016, China.
authors.forename: Qiwang
authors.initials: Q
authors.lastname: Cao
authors.forename: Dong
authors.initials: D
authors.lastname: Huang
authors.forename: Huiqiao
authors.initials: H
authors.lastname: Xu
authors.forename: Liping
authors.initials: L
authors.lastname: Wu
authors.forename: Sihan
authors.initials: S
authors.lastname: Gu
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary*; D059390:Breakthrough Pain / Q000188:drug therapy*; D006801:Humans; D007278:Injections, Spinal; D009020:Morphine; D010147:Pain Measurement; D010149:Postoperative Pain; D000069583:Pregabalin; D017409:Sufentanil / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D017409:Sufentanil