title: An assessment by the Statin Muscle Safety Task Force: 2014 update.
abstract: The National Lipid Association's Muscle Safety Expert Panel was charged with the duty of examining the definitions for statin-associated muscle adverse events, development of a clinical index to assess myalgia, and the use of diagnostic neuromuscular studies to investigate muscle adverse events. We provide guidance as to when a patient should be considered for referral to neuromuscular specialists and indications for the performance of a skeletal muscle biopsy. Based on this review of evidence, we developed an algorithm for the evaluation and treatment of patients who may be intolerant to statins as the result of adverse muscle events. The panel was composed of clinical cardiologists, clinical lipidologists, an exercise physiologist, and a neuromuscular specialist.
authors.affiliation: Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address: robert.rosenson@mssm.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Rosenson
authors.affiliation: McMaster University, Hamilton, ON, Canada.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Baker
authors.affiliation: Emory University, Atlanta, GA, USA.
authors.forename: Terry A
authors.initials: TA
authors.lastname: Jacobson
authors.affiliation: Mayo Clinic, Rochester, MN, USA.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Kopecky
authors.affiliation: Department of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA.
authors.forename: Beth A
authors.initials: BA
authors.lastname: Parker
authors.lastname: The National Lipid Association's Muscle Safety Expert Panel
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D003402:Creatine Kinase / Q000378:metabolism; D019317:Evidence-Based Medicine; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006938:Hyperlipoproteinemia Type II / Q000150:complications; D018482:Muscle, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology / Q000473:pathology; D063806:Myalgia / Q000209:etiology / Q000473:pathology; D014807:Vitamin D / Q000097:blood
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014807:Vitamin D; D003402:Creatine Kinase
keywords: Muscle adverse events; Myalgia; Myopathy; Neuromuscular testing; Rhabdomyolysis; Statin intolerance; Statins