title: [Morphofunctional state of reproductive system of ageing male rats in case of using nanocerium].
abstract: The influence of nanocrystalline cerium dioxide (NCD, 1 and 100 mg/kg per os daily for 10 days) on morphofuctional state of reproductive system was investigated in ageing male rats. It has been established that activation of hormone-producing testicular Leydig's cells, as well as of secretory and proliferative processes in prostate, underlies the stimulating effect of NCD at a dose 1 mg/kg on hormonal function of testis and spermatogenesis of ageing male rats. NCD used at a dose 100 mg/kg had no significant effect on the assessed indices of morphofuctional state of reproductive system.
authors.forename: N D
authors.initials: ND
authors.lastname: Nosenko
authors.forename: N M
authors.initials: NM
authors.lastname: Zholobak
authors.forename: L I
authors.initials: LI
authors.lastname: Poliakova
authors.forename: P V
authors.initials: PV
authors.lastname: Sinitsyn
authors.forename: A A
authors.initials: AA
authors.lastname: Lymarieva
authors.forename: O V
authors.initials: OV
authors.lastname: Shcherbakov
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Spivak
authors.forename: O H
authors.initials: OH
authors.lastname: Reznikov
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002563:Cerium / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D042341:Gonadal Hormones / Q000378:metabolism; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D053758:Nanoparticles; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D042341:Gonadal Hormones; D002563:Cerium; C030583:ceric oxide