title: [Carcinoma-associated fibroblasts in cancer: the great escape].
abstract: Cellular and molecular crosstalks between cancer and non-cancer tumor-associated cells result in tumor growth and metastatic spreading. During carcinoma development, tumor cells secrete signaling molecules that influence the surrounding non-cancer cells, which, in return, favor tumor cell growth, survival, migration and metastasis. Carcinoma-associated fibroblasts (CAF) are the most abundant population of non-cancer cells found in tumors, and their presence is often associated with poor clinical prognosis. Here, we summarize the pro-carcinogenic roles of CAF cells during carcinogenesis, with a specific focus on their abilities to drive cancer cell-dependent pro-invasive extracellular matrix remodeling.
authors.affiliation: Inserm U1081, CNRS UMR7284, Université Nice Sophia Antipolis, IRCAN, Institut de recherche sur le cancer et le vieillissement, Faculté de médecine, 28, avenue de Valombrose, 06107 Nice, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Albrengues
authors.affiliation: Inserm U1081, CNRS UMR7284, Université Nice Sophia Antipolis, IRCAN, Institut de recherche sur le cancer et le vieillissement, Faculté de médecine, 28, avenue de Valombrose, 06107 Nice, France.
authors.forename: Guerrino
authors.initials: G
authors.lastname: Meneguzzi
authors.affiliation: Inserm U1081, CNRS UMR7284, Université Nice Sophia Antipolis, IRCAN, Institut de recherche sur le cancer et le vieillissement, Faculté de médecine, 28, avenue de Valombrose, 06107 Nice, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Gaggioli
mesh_terms: D005347:Fibroblasts; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment