title: [Study thought of material basis of secondary development of major traditional Chinese medicine varieties on basis of combination of in vivo and in vitro experiments].
abstract: The secondary development of major traditional Chinese medicine varieties is one of important links during the modernization, scientification and standardization of traditional Chinese medicines. How to accurately and effectively identify the pharmacodynamic material basis of original formulae becomes the primary problem in the secondary development, as well as the bottleneck in the modernization development of traditional Chinese medicines. On the basis of the existing experimental methods, and according to the study thought that the multi-component and complex effects of traditional Chinese medicine components need to combine multi-disciplinary methods and technologies, we propose the study thought of the material basis of secondary development of major traditional Chinese medicine varieties based on the combination of in vivo and in vitro experiments. It is believed that studies on material basis needs three links, namely identification, screening and verification, and in vivo and in vitro study method corresponding to each link is mutually complemented and verified. Finally, the accurate and reliable material basis is selected. This thought provides reference for the secondary development of major traditional Chinese medicine varieties and studies on compound material basis.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Cheng
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000042:Absorption; D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*