title: Why should we need the gut microbiota to respond to cancer therapies?
abstract: Cyclophosphamide, one of the most efficient tumoricidal, antiangiogenic, and immunostimulatory drugs employed to date mediates part of its effects through intestinal bacteria, against which the host becomes immunized during treatment. Our recent work suggests that anti-commensal effector pTH17 and memory TH1 CD4+T-cell responses are indispensable for optimal anticancer effects as mediated by cyclophosphamide.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Viaud
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.
authors.forename: Romain
authors.initials: R
authors.lastname: Daillère
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: Institut National de la Recherche Agronomique, Micalis; UMR1319; Jouy-en-Josas, France ; AgroParisTech; Micalis; UMR1319; Jouy-en-Josas, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Lepage
authors.affiliation: Unit of Biology and Genetics of the Bacterial Cell Wall; Institut Pasteur; Paris, France ; Institut National de la Santé et de la Recherche Médicale; Group Avenir; Paris, France.
authors.forename: Ivo
authors.initials: I
authors.lastname: Boneca
authors.affiliation: Cancer and Inflammation Program; National Cancer Institute; Frederick, MD USA.
authors.forename: Romina
authors.initials: R
authors.lastname: Goldszmid
authors.affiliation: Cancer and Inflammation Program; National Cancer Institute; Frederick, MD USA.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trinchieri
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Centre d'Investigation Clinique Biothérapie CICBT 507; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
keywords: Gram-positive bacteria; antibiotics; cancer; chemotherapy; immunomodulatory regimen; microbiota; pTh17