title: Transoral Robotic Surgery in the HPV Era.
abstract: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades mostly due to human papillomavirus (HPV)-related infections. Cancers resulting from HPV infection bear a better prognosis than those that are smoking-related. Because HPV-positive patients are often younger, with lower rates of co-morbid illness and longer overall life expectancies, long-term sequelae of therapy have become an important issue. Treatment of oropharyngeal cancers has typically involved the use of radiation and chemotherapy to avoid the morbidity of open surgery which included mandibulotomy and composite resection. Transoral robotic surgery (TORS) is an emerging treatment option for this disease, avoiding the morbidity of open approaches while providing excellent oncologic and functional outcomes. With overall survival rate at 2 years exceeding 80%, and local failure rate of less than 3%, patients receiving TORS report relatively good health-related quality of life (QOL) scores. The aim of the current review is to provide a summary of the current literature with regard to the oncologic and functional outcomes following treatment of OPSCC with TORS.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel;
authors.forename: Irit
authors.initials: I
authors.lastname: Duek
authors.affiliation: The Oncology Institute, Rambam Health Care Campus, Haifa, Israel;
authors.forename: Salem
authors.initials: S
authors.lastname: Billan
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel; ; The Laboratory for Applied Cancer Research, the Clinical Research Institute, Rambam Health Care Campus, The Technion, Haifa, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Amit
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel; ; The Laboratory for Applied Cancer Research, the Clinical Research Institute, Rambam Health Care Campus, The Technion, Haifa, Israel.
authors.forename: Ziv
authors.initials: Z
authors.lastname: Gil
keywords: da Vinci® Surgical System; human papillomavirus; minimally invasive; oropharyngeal squamous cell carcinoma; transoral robotic surgery