title: EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells.
abstract: An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR. klwong@hkbu.edu.hk.
authors.forename: Lijun
authors.initials: L
authors.lastname: Jiang
authors.forename: Yin-Lai
authors.initials: YL
authors.lastname: Lui
authors.forename: Hongguang
authors.initials: H
authors.lastname: Li
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Chan
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Lan
authors.forename: Wai-Lun
authors.initials: WL
authors.lastname: Chan
authors.forename: Terrence Chi-Kong
authors.initials: TC
authors.lastname: Lau
authors.forename: George Sai-Wah
authors.initials: GS
authors.lastname: Tsao
authors.forename: Nak-Ki
authors.initials: NK
authors.lastname: Mak
authors.forename: Ka-Leung
authors.initials: KL
authors.lastname: Wong
mesh_terms: D001665:Binding Sites; D002470:Cell Survival / Q000187:drug effects; D019281:Dimerization; D019309:Epstein-Barr Virus Nuclear Antigens / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D004854:Herpesvirus 4, Human / Q000378:metabolism*; D006801:Humans; D018613:Microscopy, Confocal; D062105:Molecular Docking Simulation; D017434:Protein Structure, Tertiary; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; D011726:Pyridinium Compounds; C417029:EBV-encoded nuclear antigen 1