title: Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain.
abstract: The two cold shock domain containing proteins, Y-box-binding protein-1 and cold shock domain protein A were immunolocalized in developing and adult human brain. With the exception of a small population of hypothalamic astrocytes, brain Y-box-binding protein-1 was predominantly found in multiple neurons in the mature human CNS, which might be related to its involvement in neurotransmission and other neuron-associated functions. Cold shock domain protein A was typically observed in astrocytes, oligodendrocytes, choroid plexus epithelia and nerve fibers. However, in circumscribed brain regions as hypothalamus, habenula, and cerebellum, this protein was also expressed in neurons. In the prenatal brain, both proteins were found to be abundantly expressed in radial glial cells, neuroblasts and neurons, which might be an anatomical correlate of the proposed roles of both proteins in cell proliferation and differentiation. In addition, Y-box-binding protein-1 was identified in cultured, lipopolysaccharide-stimulated microglial cells, which underscores its putative role as a mediator in immune and inflammatory processes.
authors.affiliation: Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany, Hans-Gert.Bernstein@med.ovgu.de.
authors.forename: Hans-Gert
authors.initials: HG
authors.lastname: Bernstein
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Lindquist
authors.forename: Gerburg
authors.initials: G
authors.lastname: Keilhoff
authors.forename: Henrik
authors.initials: H
authors.lastname: Dobrowolny
authors.forename: Sabine
authors.initials: S
authors.lastname: Brandt
authors.forename: Johann
authors.initials: J
authors.lastname: Steiner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bogerts
authors.forename: Peter R
authors.initials: PR
authors.lastname: Mertens
mesh_terms: D001921:Brain / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism*; D002135:Calcium-Binding Proteins; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D005333:Fetus; D005786:Gene Expression Regulation / Q000187:drug effects; D005865:Gestational Age; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008840:Microfilament Proteins; D008875:Middle Aged; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051840:Y-Box-Binding Protein 1 / Q000378:metabolism*
chemical_list: C112986:AIF1 protein, human; D022762:CCAAT-Enhancer-Binding Proteins; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D006360:Heat-Shock Proteins; D008070:Lipopolysaccharides; D008840:Microfilament Proteins; D051840:Y-Box-Binding Protein 1; C094867:YBX3 protein, human