title: Eosinophilic esophagitis: clinical presentation in children.
abstract: Eosinophilic esophagitis (EoE) is increasing in western nations. Symptoms in infants and young children include feeding difficulties, failure to thrive, and gastroesophageal reflux. School-aged children may present with vomiting, abdominal pain, and regurgitation; adolescents and adults with dysphagia and food impaction. Delayed diagnosis increases risk of stricture formation. Children with untreated EoE have tissue changes resembling airway remodeling. Endoscopy does not always correlate. Management centers on food elimination. Approaches include skin prick and patch testing, removal of foods, or an amino acid formula diet. Long-term elimination diets can produce nutritional deficiencies and have poor adherence.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: liacouras@email.chop.edu.
authors.forename: Chris A
authors.initials: CA
authors.lastname: Liacouras
authors.affiliation: Division of Allergy, Immunology, and Infectious Diseases, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Spergel
authors.affiliation: Division of Allergy, Immunology, and Infectious Diseases, Center for Pediatric Eosinophilic Disorders, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Gober
mesh_terms: D002648:Child; D057765:Eosinophilic Esophagitis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans
keywords: Children; EoE; Eosinophil; Esophagitis; Pediatric