title: Spontaneous splenic rupture in melanoma.
abstract: Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild splenomegaly with moderate free fluid in abdominopelvic cavity. Considering acute abdominal pain and hemodynamic instability, he underwent splenectomy with splenic rupture as the source of bleeding. Histologic examination showed diffuse infiltration by tumor. Immunohistochemical study (positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin) confirmed metastatic malignant melanoma. On further questioning, there was a past history of a nasal dark skin lesion which was removed two years ago with no pathologic examination. Spontaneous (nontraumatic) rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Metastasis of malignant melanoma is one of the rare causes of the spontaneous rupture of spleen.
authors.affiliation: Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hadi
authors.identifier: 0000-0001-9299-8928
authors.initials: H
authors.lastname: Mirfazaelian
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Oryan
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Aida
authors.initials: A
authors.lastname: Davari
authors.affiliation: Dr. Daneshbod Pathology Laboratory, Department of Pathology, Shiraz, Iran.
authors.forename: Khosrow
authors.initials: K
authors.lastname: Daneshbod
authors.affiliation: Dr. Daneshbod Pathology Laboratory, Department of Pathology, Shiraz, Iran.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod