title: Nanomolar detection of hypochlorite by a rhodamine-based chiral hydrazide in absolute aqueous media: application in tap water analysis with live-cell imaging.
abstract: By employing the oxidation property of hypochlorite (OCl(-)), a novel rhodamine-based hydrazide of the chiral acid ((S)-(-)-2-pyrrolidone-5-carboxylic acid) (RHHP) was designed and synthesized for detection of OCl(-) absolutely in aqueous medium at nanomolar level. The structure of the chiral sensor was also proved by the X-ray crystallography. The bioactivity and the application of the probe for detection of OCl(-) in natural water system have been demonstrated. A plausible mechanism for oxidation of the sensor followed by hydrolysis is also proposed. The sensibility of the receptor toward OCl(-) was studied in absolute aqueous media, and the detection limit of hypochlorite-mediated oxidation to the receptor in nanomolar level makes this platform (RHHP) an ultrasensitive and unique system for OCl(-) oxidation.
authors.affiliation: Department of Chemistry, Indian Institute of Engineering Science and Technology (formerly Bengal Engineering and Science University) , Shibpur, Howrah, West Bengal 711103, India.
authors.forename: Shyamaprosad
authors.initials: S
authors.lastname: Goswami
authors.forename: Avijit Kumar
authors.initials: AK
authors.lastname: Das
authors.forename: Abhishek
authors.initials: A
authors.lastname: Manna
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Maity
authors.forename: Partha
authors.initials: P
authors.lastname: Saha
authors.forename: Ching Kheng
authors.initials: CK
authors.lastname: Quah
authors.forename: Hoong-Kun
authors.initials: HK
authors.lastname: Fun
authors.forename: Hatem A
authors.initials: HA
authors.lastname: Abdel-Aziz
mesh_terms: D018360:Crystallography, X-Ray; D003593:Cytoplasm / Q000737:chemistry* / Q000648:ultrastructure; D060766:Drinking Water / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D006868:Hydrolysis; D006997:Hypochlorous Acid / Q000032:analysis*; D057230:Limit of Detection; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D061848:Optical Imaging; D010084:Oxidation-Reduction; D011760:Pyrrolidinones / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry*
chemical_list: D060766:Drinking Water; D005456:Fluorescent Dyes; D006834:Hydrazines; D011760:Pyrrolidinones; D012235:Rhodamines; C029424:hydrazine; D006997:Hypochlorous Acid; C028537:2-pyrrolidone