title: α-synuclein in the inner retina in parkinson disease.
abstract: Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α-synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α-synuclein gives clues to the nonsynaptic mode of α-synuclein propagation.
authors.affiliation: Departments of Neurology, SUNY Downstate Medical Center, Brooklyn; Departments of Ophthalmology, SUNY Downstate Medical Center, Brooklyn; SUNY Eye Institute, Syracuse.
authors.forename: Ivan
authors.initials: I
authors.lastname: Bodis-Wollner
authors.forename: Piotr B
authors.initials: PB
authors.lastname: Kozlowski
authors.forename: Sofya
authors.initials: S
authors.lastname: Glazman
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Miri
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000473:pathology*; D012160:Retina / Q000378:metabolism* / Q000473:pathology*; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein