title: Potent health effects of pomegranate.
abstract: Accumulating data clearly claimed that Punica granatum L. (pomegranate) has several health benefits. Pomegranates can help prevent or treat various disease risk factors including high blood pressure, high cholesterol, oxidative stress, hyperglycemia, and inflammatory activities. It is demonstrated that certain components of pomegranate such as polyphenols have potential antioxidant, anti-inflammatory, and anticarcinogenic effects. The antioxidant potential of pomegranate juice is more than that of red wine and green tea, which is induced through ellagitannins and hydrosable tannins. Pomegranate juice can reduce macrophage oxidative stress, free radicals, and lipid peroxidation. Moreover, pomegranate fruit extract prevents cell growth and induces apoptosis, which can lead to its anticarcinogenic effects. In addition, promoter inhibition of some inflammatory markers and their production are blocked via ellagitannins. In this article, we highlight different studies on the therapeutic effects of pomegranate and their suggested mechanisms of actions.
authors.affiliation: Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran.
authors.forename: Aida
authors.initials: A
authors.lastname: Zarfeshany
authors.affiliation: Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Asgary
authors.affiliation: Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran.
authors.forename: Shaghayegh Haghjoo
authors.initials: SH
authors.lastname: Javanmard
keywords: Antioxidant; inflammatory activities; pomegranate