title: A meta-analysis of P2X7 gene-762T/C polymorphism and pulmonary tuberculosis susceptibility.
abstract: OBJECTIVE
  We performed a comprehensive meta-analysis to determine the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis susceptibility.
  
  
  METHODS
  Based on comprehensive searches of the PubMed, SCI, Elsevier, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis risk. Pooled odds ratio (ORs) and 95% confidence intervals (95%CIs) were calculated in random-effects model.
  
  
  RESULTS
  A total of 2207 tuberculosis cases and 2220 controls in 8 case-control studies were included in this meta-analysis. Allele model (C vs. T: p = 0.15; OR = 0.83, 95% CI = 0.65-1.07), homozygous model (CC vs. TT: p = 0.23; OR = 0.73, 95% CI = 0.44 to 1.22), and heterozygous model (CT vs. TT: p = 0.57; OR = 0.92, 95% CI = 0.68 to 1.24) did not show increased risk of developing pulmonary tuberculosis. Similarly, dominant model (CC+CT vs. TT: p = 0.32; OR = 0.84, 95% CI = 0.59 to 1.19) and recessive model (CC vs. CT+TT: p = 0.08; OR = 0.77, 95% CI = 0.57 to 1.04) failed to show increased risk of developing pulmonary tuberculosis. Subgroup analysis by ethnicity did not detect any significant association between P2X7-762T/C polymorphism and pulmonary tuberculosis susceptibility.
  
  
  CONCLUSIONS
  P2X7 -762T/C gene polymorphism is not associated with pulmonary tuberculosis susceptibility.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Huo
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Respiratory Diseases, Ministry of Health, Wuhan, Hubei, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhen
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D058486:Receptors, Purinergic P2X7