title: Small cell type neuroendocrine carcinoma colliding with squamous cell carcinoma at esophagus.
abstract: Collision tumor is an extremely rare tumor which defined as the concrescence of two distinct primaries neoplasms. We report here a case of collision tumor at lower third esophagus composed of small cell type neuroendocrine carcinoma (NEC), which is an very rare, highly aggressive and poorly prognostic carcinoma and squamous cell carcinoma (SqCC). In our case, pathologically, the small cell carcinoma display the characteristic of small, round, ovoid or spindle-shaped tumor cells with scant cytoplasm, which colliding with a moderately differentiated squamous cell carcinoma. Immunohistochemical staining demonstrated positive activities for CD56, synaptophysin, 34βE12, CK 5/6, ki-67 (70%-80%), but negative for CD99, chromogranin A, and TTF-1. Accurate diagnosis was made base on these findings.
authors.affiliation: Department of Gastroenterology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Luoluo
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pathology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Pathology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Yabin
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Gastroenterology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000368:Aged; D019002:CD56 Antigen / Q000378:metabolism; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000453:epidemiology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology* / Q000601:surgery; D015897:Comorbidity; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000601:surgery; D004947:Esophagus / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D053555:Keratin-5 / Q000378:metabolism; D053553:Keratin-6 / Q000378:metabolism; D008297:Male; D016708:Synaptophysin / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D019002:CD56 Antigen; D053555:Keratin-5; D053553:Keratin-6; D016708:Synaptophysin
keywords: Collision tumor; esophagus; neuroendocrine carcinoma; small cell type; squamous cell carcinoma