title: Cell migration: from tissue culture to embryos.
abstract: Cell migration is a fundamental process that occurs during embryo development. Classic studies using in vitro culture systems have been instrumental in dissecting the principles of cell motility and highlighting how cells make use of topographical features of the substrate, cell-cell contacts, and chemical and physical environmental signals to direct their locomotion. Here, we review the guidance principles of in vitro cell locomotion and examine how they control directed cell migration in vivo during development. We focus on developmental examples in which individual guidance mechanisms have been clearly dissected, and for which the interactions among guidance cues have been explored. We also discuss how the migratory behaviours elicited by guidance mechanisms generate the stereotypical patterns of migration that shape tissues in the developing embryo.
authors.affiliation: Anatomy and Developmental Biology Program, Institute of Biomedical Sciences.
authors.forename: Germán
authors.initials: G
authors.lastname: Reig
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pulgar
authors.forename: Miguel L
authors.initials: ML
authors.lastname: Concha
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D046149:Embryo Culture Techniques; D047108:Embryonic Development; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D046509:Tissue Culture Techniques
keywords: Cell migration; Cell-cell contact; Embryo development; Environmental signals; Guidance cues; Tissue culture