title: Reduced bone and body mass in young male rats exposed to lead.
abstract: The aim of this study was to see whether there would be differences in whole blood versus tibia lead concentrations over time in growing rats prenatally. Lead was given in the drinking water at 30 mg/L from the time the dams were pregnant until offspring was 28- or 60-day-old. Concentrations of lead were measured in whole blood and in tibia after 28 (28D) and 60 days (60D) in control (C) and in lead-exposed animals (Pb). Lead measurements were made by GF-AAS. There was no significant difference (P > 0.05) in the concentration of whole blood lead between Pb-28D (8.0 ± 1.1  μg/dL) and Pb-60D (7.2 ± 0.89  μg/dL), while both significantly varied (P < 0.01) from controls (0.2  μg/dL). Bone lead concentrations significantly varied between the Pb-28D (8.02 ± 1.12  μg/g) and the Pb-60D (43.3 ± 13.26  μg/g) lead-exposed groups (P < 0.01), while those exposed groups were also significantly higher (P < 0.0001) than the 28D and 60D control groups (Pb < 1  μg/g). The Pb-60D group showed a 25% decrease in tibia mass as compared to the respective control. The five times higher amount of lead found in the bone of older animals (Pb-60D versus Pb-28D), which reinforces the importance of using bone lead as an exposure biomarker.
authors.affiliation: Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Fellipe Augusto Tocchini
authors.initials: FA
authors.lastname: de Figueiredo
authors.affiliation: Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Raquel Fernanda
authors.initials: RF
authors.lastname: Gerlach
authors.affiliation: Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Márcia Andreia Mesquita Silva
authors.initials: MA
authors.lastname: da Veiga
authors.affiliation: Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Flavio Venancio
authors.initials: FV
authors.lastname: Nakadi
authors.affiliation: Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Junia
authors.initials: J
authors.lastname: Ramos
authors.affiliation: Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Erika Reiko
authors.initials: ER
authors.lastname: Kawakita
authors.affiliation: Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: Carolina de Souza
authors.initials: Cde S
authors.lastname: Guerra
authors.affiliation: Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
authors.forename: João Paulo Mardegan
authors.initials: JP
authors.lastname: Issa
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D005260:Female; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D051381:Rats; D013977:Tibia / Q000737:chemistry / Q000187:drug effects*
chemical_list: D007854:Lead