title: Baseline proteinuria, urinary osmotic pressure, and renal function as positive predictors of corticosteroids plus cyclophosphamide treatment efficacy in IgA nephropathy.
abstract: BACKGROUND
  Very limited data are available on factors predictive of corticosteroids plus cyclophosphamide treatment efficacy on IgA nephropathy (IgAN). The aim of the study was to research the clinical factors predictive of treatment efficacy in IgAN.
  
  
  METHODS
  One hundred and fifty-nine patients with IgAN (proteinuria ≥2 g/d and estimated glomerular filtration rate 30-89 ml×min(-1)×1.73 m(-2)) were treated with corticosteroids/cyclophosphamide followed by a 12-month follow-up. According to their response, these patients were divided into remission group (proteinuria <0.5 g/d) and non-remission group (proteinuria ≥0.5 g/d), and their clinical data collected.
  
  
  RESULTS
  In the present study, 72.96% of the individuals underwent a complete remission, and their response was related to baseline proteinuria, urinary osmotic pressure, and renal function (P < 0.05). Patients with baseline proteinuria more than 3 g/d, urinary osmotic pressure greater than 600 mOsm/L, and eGFR 60-89 ml×min(-1)×1.73 m(-2) responded well to the combination of corticosteroids and cyclophosphamide (86.90% vs. 57.33%, P = 0.000; 81.48% vs. 64.10%, P = 0.014; 83.17% vs. 55.17%, P = 0.000).
  
  
  CONCLUSIONS
  The response to the combination of corticosteroids and cyclophosphamide might be well associated with baseline proteinuria, urinary osmotic pressure, and renal function in patients with IgAN.
authors.affiliation: Nephrology Department, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.affiliation: Nephrology Department, China-Japan Friendship Hospital, Beijing 100029, China. Email: wenge_lee2002@126.com.
authors.forename: Wenge
authors.initials: W
authors.lastname: Li
authors.affiliation: Nephrology Department, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Li
authors.affiliation: Nephrology Department, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure / Q000502:physiology; D011507:Proteinuria / Q000188:drug therapy / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide