title: Magnetic hyperthermia efficiency in the cellular environment for different nanoparticle designs.
abstract: Magnetic hyperthermia mediated by magnetic nanomaterials is one promising antitumoral nanotherapy, particularly for its ability to remotely destroy deep tumors. More and more new nanomaterials are being developed for this purpose, with improved heat-generating properties in solution. However, although the ultimate target of these treatments is the tumor cell, the heating efficiency, and the underlying mechanisms, are rarely studied in the cellular environment. Here we attempt to fill this gap by making systematic measurements of both hyperthermia and magnetism in controlled cell environments, using a wide range of nanomaterials. In particular, we report a systematic fall in the heating efficiency for nanomaterials associated with tumour cells. Real-time measurements showed that this loss of heat-generating power occurred very rapidly, within a matter of minutes. The fall in heating correlated with the magnetic characterization of the samples, demonstrating a complete inhibition of the Brownian relaxation in cellular conditions.
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Corato
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Ana
authors.initials: A
authors.lastname: Espinosa
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Lenaic
authors.initials: L
authors.lastname: Lartigue
authors.affiliation: Institut de Physique du Globe de Paris, UMR 7154, CNRS and Université Paris Diderot, 75205 Paris Cedex 13 France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Tharaud
authors.affiliation: INRA, UR1196 GPL, MIMA2- Plateau de Microscopie Electronique 78352 Jouy-en-Josas, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Chat
authors.affiliation: Istituto Italiano di Tecnologia, I-16163 Genova, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
authors.affiliation: Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, Université Pierre et Marie Curie UPMC-CNRS, 75252 Paris Cedex 05, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Ménager
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Gazeau
authors.affiliation: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 75205 Paris Cedex 13, France. Electronic address: claire.wilhelm@univ-paris-diderot.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Wilhelm
mesh_terms: D016880:Anisotropy; D045744:Cell Line, Tumor; D002470:Cell Survival; D060833:Cellular Microenvironment; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D060328:Magnetic Phenomena; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D012996:Solutions; D013054:Spectrophotometry, Atomic
chemical_list: D012996:Solutions
keywords: Cell interactions; Magnetic hyperthermia; Nanomagnetism; Nanomedicine; Nanoparticles