title: Biological characteristics and gene expression pattern of bone marrow mesenchymal stem cells in patients with psoriasis.
abstract: Mesenchymal stem cells (MSCs) have immunoregulatory and proangiogenic effects and are suggested to be involved in the pathological processes of immune-related diseases, including psoriasis. Biological characteristics of bone marrow MSCs (BMSCs) from patients with autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis, but not psoriasis, have been characterized. We compared the gene expression profile and biological characteristics of BMSCs from patients with psoriasis and healthy controls. Although the phenotype, differentiation potential and ability to support CD34(+) cell proliferation were similar to those of normal BMSCs, psoriatic BMSCs showed aberrant proliferative activity, increased apoptosis rate and a characteristic gene expression profile. These aberrations may develop after the abnormal immune response in psoriasis and result in BMSC dysfunction. The functionally deficient BMSCs may then fail to suppress overactive immune cells, thereby contributing to the pathogenesis of psoriasis.
authors.affiliation: Institute of Dermatology, Taiyuan City Central Hospital, Taiyuan, China.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Hou
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Liu
authors.forename: Xuping
authors.initials: X
authors.lastname: Niu
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Chang
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
authors.forename: Chunfang
authors.initials: C
authors.lastname: Wang
authors.forename: Junqin
authors.initials: J
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: An
authors.forename: Xinhua
authors.initials: X
authors.lastname: Li
authors.forename: Guohua
authors.initials: G
authors.lastname: Yin
authors.forename: Kaiming
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D017209:Apoptosis; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D064368:Healthy Volunteers; D006801:Humans; D007249:Inflammation; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D011565:Psoriasis / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D018952:Antigens, CD34
keywords: apoptosis; mesenchymal stem cells; microarray; proliferation activity; psoriasis