title: Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
abstract: Salivary, serum matrix metalloproteinase-8 (MMP-8), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), and myeloperoxidase (MPO) levels were investigated in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy groups. Whole-mouth clinical periodontal measurements were recorded. Salivary, serum concentrations of MMP-8, MPO, TIMP-1, and NE were determined by immunofluorometric assay or ELISA in 18 patients with GCP, 23 patients with GAgP, 18 individuals with healthy periodontium. Patients in the GAgP group were younger than the other groups (p<0.05). The study groups were similar in gender, smoking status. Plaque index was higher in GCP than GAgP group (p<0.05). Biochemical data were similar in periodontitis groups. Salivary, serum MPO, and salivary NE concentrations were higher; TIMP-1 concentrations were lower in the periodontitis groups than the controls (p<0.05). The present data support a close relationship between salivary, serum protease content and clinical periodontal parameters in patients with generalized periodontitis.
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, İzmir, Turkey.
authors.forename: Nejat
authors.initials: N
authors.lastname: Nizam
authors.forename: Pınar
authors.initials: P
authors.lastname: Gümüş
authors.forename: Jari
authors.initials: J
authors.lastname: Pitkänen
authors.forename: Taina
authors.initials: T
authors.lastname: Tervahartiala
authors.forename: Timo
authors.initials: T
authors.lastname: Sorsa
authors.forename: Nurcan
authors.initials: N
authors.lastname: Buduneli
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D055113:Chronic Periodontitis / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D019272:Leukocyte Elastase / Q000032:analysis / Q000097:blood*; D008297:Male; D020782:Matrix Metalloproteinases / Q000032:analysis / Q000097:blood*; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis / Q000097:blood*; D012463:Saliva / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D009195:Peroxidase; D019272:Leukocyte Elastase; D020782:Matrix Metalloproteinases