title: [Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration].
abstract: The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: G A
authors.initials: GA
authors.lastname: Chernysheva
authors.forename: E A
authors.initials: EA
authors.lastname: Ianovskaia
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: A V
authors.initials: AV
authors.lastname: Kuchin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Chukicheva
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001892:Camphanes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003408:Cresols / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D007408:Intestinal Absorption / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach
chemical_list: C533990:4-methyl-2,6-diisobornylphenol; D000975:Antioxidants; D001892:Camphanes; D003408:Cresols