title: Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors.
abstract: Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors' ability to permeate bacteria to produce NO when exposed to H2O2 supporting possible applications for BORO/NO to study molecular mechanisms of NO generation in response to elevated ROS.
authors.affiliation: Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra, India.
authors.forename: Allimuthu T
authors.initials: AT
authors.lastname: Dharmaraja
authors.forename: Govindan
authors.initials: G
authors.lastname: Ravikumar
authors.forename: Harinath
authors.initials: H
authors.lastname: Chakrapani
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000138:chemical synthesis / Q000737:chemistry; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D001896:Boron Compounds; D020030:Nitric Oxide Donors; D017382:Reactive Oxygen Species; C452539:diazeniumdiolate; D009569:Nitric Oxide; D006861:Hydrogen Peroxide