title: Contributions of the Computer-Administered Neuropsychological Screen for Mild Cognitive Impairment (CANS-MCI) for the diagnosis of MCI in Brazil.
abstract: BACKGROUND
  The Computer-Administered Neuropsychological Screen for Mild Cognitive Impairment (CANS-MCI) is a computer-based cognitive screening instrument that involves automated administration and scoring and immediate analyses of test sessions. The objective of this study was to translate and culturally adapt the Brazilian Portuguese version of the CANS-MCI (CANS-MCI-BR) and to evaluate its reliability and validity for the diagnostic screening of MCI and dementia due to Alzheimer's disease.
  
  
  METHODS
  The test was administered to 97 older adults (mean age 73.41 ± 5.27 years) with at least four years of formal education (mean education 12.23 ± 4.48 years). Participants were classified into three diagnostic groups according to global cognitive status (normal controls,n= 41; MCI,n= 35; AD,n= 21) based on clinical data and formal neuropsychological assessments.
  
  
  RESULTS
  The results indicated high internal consistency (Cronbach'sα= 0.77) in the total sample. Three-month test-retest reliability correlations were significant and robust (0.875; p < 0.001). A moderate level of concurrent validity was attained relative to the screening test for MCI (MoCA test,r= 0.76, p < 0.001). Confirmatory factor analysis supported the three-factor model of the original test, i.e., memory, language/spatial fluency, and executive function/mental control. Goodness of fit indicators were strong (Bentler Comparative Fit Index = 0.96, Root Mean Square Error of Approximation = 0.09). Receiver operating characteristic curve analyses suggested high sensitivity and specificity (81% and 73% respectively) to screen for possible MCI cases.
  
  
  CONCLUSIONS
  The CANS-MCI-BR maintains adequate psychometric characteristics that render it suitable to identify elderly adults with probable cognitive impairment to whom a more extensive evaluation by formal neuropsychological tests may be required.
authors.affiliation: Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Cláudia M
authors.initials: CM
authors.lastname: Memória
authors.affiliation: Department of Gerontology, School of Arts, Sciences and Humanities (EACH), University of São Paulo, São Paulo, Brazil.
authors.forename: Mônica S
authors.initials: MS
authors.lastname: Yassuda
authors.affiliation: Department of Statistics, University of Brasília (UNB), Brasília, Brazil.
authors.forename: Eduardo Y
authors.initials: EY
authors.lastname: Nakano
authors.affiliation: Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Orestes V
authors.initials: OV
authors.lastname: Forlenza
mesh_terms: D006801:Humans; D060825:Cognitive Dysfunction / Q000175:diagnosis; D008297:Male; D005260:Female; D009483:Neuropsychological Tests / Q000592:standards; D000368:Aged; D001938:Brazil; D015203:Reproducibility of Results; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis; D011594:Psychometrics; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D008403:Mass Screening / Q000379:methods; D012680:Sensitivity and Specificity
keywords: cognitive screening; computerized tests; dementia; elderly; mild cognitive impairment; neuropsychology