title: A case of tinnitus induced by chlorpromazine in a pediatric patient.
abstract: Chlorpromazine is a well-known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12-year-old boy, affected by severe generalized anxiety disorder. After treatment with chlorpromazine, the patient experienced an enhanced sensitivity to sounds accompanied by perception of noises of the buzzing or ringing type. This clinical case is of great clinical interest as chlorpromazine is not currently included among potentially ototoxic drugs.
authors.affiliation: Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Carnovale
authors.affiliation: Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pellegrino
authors.affiliation: Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Beretta
authors.affiliation: Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: Gian Vincenzo
authors.initials: GV
authors.lastname: Zuccotti
authors.affiliation: Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Perrone
authors.affiliation: Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Antoniazzi
authors.affiliation: Scientific Institute for Research, Hospitalization and Health Care Eugenio Medea, Bosisio Parini, Lecco, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Pozzi
authors.affiliation: Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy ; Scientific Institute for Research, Hospitalization and Health Care Eugenio Medea, Bosisio Parini, Lecco, Italy.
authors.forename: Emilio
authors.initials: E
authors.lastname: Clementi
authors.affiliation: Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Radice
keywords: Adverse drug reaction; chlorpromazine; tinnitus