title: Computational studies of DNA sequencing with solid-state nanopores: key issues and future prospects.
abstract: Owing to the potential use for real personalized genome sequencing, DNA sequencing with solid-state nanopores has been investigated intensively in recent time. However, the area still confronts problems and challenges. In this work, we present a brief overview of computational studies of key issues in DNA sequencing with solid-state nanopores by addressing the progress made in the last few years. We also highlight future challenges and prospects for DNA sequencing using this technology.
authors.affiliation: Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology Stockholm, Sweden ; Department of Chemistry and Soft Matter Research Center, Zhejiang University Hangzhou, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Chemistry and Soft Matter Research Center, Zhejiang University Hangzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology Stockholm, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Agren
authors.affiliation: Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology Stockholm, Sweden.
authors.forename: Yaoquan
authors.initials: Y
authors.lastname: Tu
keywords: DNA sequencing; bio-nanotechnology; computer modeling; graphene nanopore; molecular simulation; solid-state nanopore; theory