title: Anti-Candida activity of fluoxetine alone and combined with fluconazole: a synergistic action against fluconazole-resistant strains.
abstract: The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29 Candida strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 μg/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six Candida strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.
authors.affiliation: CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
authors.forename: Ana S
authors.initials: AS
authors.lastname: Oliveira
authors.affiliation: CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gaspar
authors.affiliation: CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal Hospital Pharmacy Department, Centro Hospitalar Cova da Beira EPE, Covilhã, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Palmeira-de-Oliveira
authors.affiliation: CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal Child and Women's Health Department, Centro Hospitalar Cova da Beira EPE, Covilhã, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Martinez-de-Oliveira
authors.affiliation: CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal apo@fcsaude.ubi.pt.
authors.forename: Ana
authors.initials: A
authors.lastname: Palmeira-de-Oliveira
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000187:drug effects*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy / Q000382:microbiology; D025141:Drug Resistance, Fungal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D005473:Fluoxetine; D015725:Fluconazole