title: Computational modeling of cardiac valve function and intervention.
abstract: In the past two decades, major advances have been made in the clinical evaluation and treatment of valvular heart disease owing to the advent of noninvasive cardiac imaging modalities. In clinical practice, valvular disease evaluation is typically performed on two-dimensional (2D) images, even though most imaging modalities offer three-dimensional (3D) volumetric, time-resolved data. Such 3D data offer researchers the possibility to reconstruct the 3D geometry of heart valves at a patient-specific level. When these data are integrated with computational models, native heart valve biomechanical function can be investigated, and preoperative planning tools can be developed. In this review, we outline the advances in valve geometry reconstruction, tissue property modeling, and loading and boundary definitions for the purpose of realistic computational structural analysis of cardiac valve function and intervention.
authors.affiliation: Tissue Mechanics Lab, The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30313; email: wei.sun@bme.gatech.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Caitlin
authors.initials: C
authors.lastname: Martin
authors.forename: Thuy
authors.initials: T
authors.lastname: Pham
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000502:physiology*; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D006351:Heart Valves / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008943:Mitral Valve / Q000502:physiology*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D011336:Probability; D012984:Software; D014018:Tissue Distribution; D023822:Tissue Engineering / Q000379:methods*
keywords: aortic valve; cardiac imaging; finite element analysis; heart valve; mitral valve