title: Strategic white matter tracts for processing speed deficits in age-related small vessel disease.
abstract: OBJECTIVE
  Cerebral small vessel disease is the most common cause of vascular cognitive impairment and typically manifests with slowed processing speed. We investigated the impact of lesion location on processing speed in age-related small vessel disease.
  
  
  METHODS
  A total of 584 community-dwelling elderly underwent brain MRI followed by segmentation of white matter hyperintensities. Processing speed was determined by the timed measure of the Trail Making Test part B. The impact of the location of white matter hyperintensities was assessed by voxel-based lesion-symptom mapping and graph-based statistical models on regional lesion volumes in major white matter tracts.
  
  
  RESULTS
  Voxel-based lesion-symptom mapping identified multiple voxel clusters where the presence of white matter hyperintensities was associated with slower performance on the Trail Making Test part B. Clusters were located bilaterally in the forceps minor and anterior thalamic radiation. Region of interest-based Bayesian network analyses on lesion volumes within major white matter tracts depicted the same tracts as direct predictors for an impaired Trail Making Test part B performance.
  
  
  CONCLUSIONS
  Our findings highlight damage to frontal interhemispheric and thalamic projection fiber tracts harboring frontal-subcortical neuronal circuits as a predictor for processing speed performance in age-related small vessel disease.
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Duering
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Benno
authors.initials: B
authors.lastname: Gesierich
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Seiler
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Pirpamer
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Mariya
authors.initials: M
authors.lastname: Gonik
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Edith
authors.initials: E
authors.lastname: Hofer
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Jouvent
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Edouard
authors.initials: E
authors.lastname: Duchesnay
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ropele
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schmidt
authors.affiliation: From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany. martin.dichgans@med.uni-muenchen.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D059345:Cerebral Small Vessel Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014145:Trail Making Test