title: Element analysis of small and even smaller objects by ICPMS and LA-ICPMS.
abstract: Inductively coupled plasma mass spectrometry is increasingly used for non-traditional applications such as the analysis of solids at high spatial resolution when combined with laser ablation or the analysis of engineered nanoparticles. This report highlights recent projects and discusses the potentials and limitations these techniques offer. High-resolution laser ablation instrumentation allows element imaging at the μm-scale and can, therefore, be applied to, e.g., the mapping of metal isotope-labeled antibodies in biological tissues. Despite these advancements, the quantitative analysis of laser-produced aerosols is still a major concern. Here, the accuracy of analysis was found to strongly depend on particle size distribution but also on the morphology and composition of particles. In order to achieve a controlled supply of nanoparticles for analysis by inductively coupled plasma mass spectrometry, a dedicated microdroplet injection system was developed and characterized. This system allows a reproducible injection of single nanoparticles together with internal standards to determine their mass and composition.
authors.forename: Olga
authors.initials: O
authors.lastname: Borovinskaya
authors.forename: Marcel
authors.initials: M
authors.lastname: Burger
authors.forename: Luca
authors.initials: L
authors.lastname: Flamigni
authors.forename: Sabrina
authors.initials: S
authors.lastname: Gschwind
authors.forename: Daniel
authors.initials: D
authors.lastname: Tabersky
authors.forename: Hao A O
authors.initials: HA
authors.lastname: Wang
authors.forename: Bodo
authors.initials: B
authors.lastname: Hattendorf
authors.forename: Joachim
authors.initials: J
authors.lastname: Koch
authors.affiliation: ETH Zurich, Department of Chemistry, Vladimir-Prelog-Weg 1, CH-8093 Zurich, Switzerland.
authors.forename: Detlef
authors.initials: D
authors.lastname: Günther