title: Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells.
abstract: We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.
authors.affiliation: Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: Allison
authors.initials: A
authors.lastname: Suarez
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Ueno
authors.affiliation: Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: Robert
authors.initials: R
authors.lastname: Huebner
authors.affiliation: Integrated Imaging Center, Department of Biology, Johns Hopkins University, Baltimore, MD 21218.
authors.forename: J Michael
authors.initials: JM
authors.lastname: McCaffery
authors.affiliation: 1] Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 [2] PRESTO Investigator, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.
authors.forename: Takanari
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000818:Animals; D019556:COS Cells; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism* / Q000502:physiology*; D002522:Chlorocebus aethiops; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D009419:Nerve Tissue Proteins; C075637:amphiphysin