title: Modeling the dissemination and uptake of clinical trials results.
abstract: A select set of highly cited publications from the National Institutes of Health (NIH) HIV/AIDS Clinical Trials Networks was used to illustrate the integration of time interval and citation data, modeling the progression, dissemination, and uptake of primary research findings. Following a process marker approach, the pace of initial utilization of this research was measured as the time from trial conceptualization, development and implementation, through results dissemination and uptake. Compared to earlier studies of clinical research, findings suggest that select HIV/AIDS trial results are disseminated and utilized relatively rapidly. Time-based modeling of publication results as they meet specific citation milestones enabled the observation of points at which study results were present in the literature summarizing the evidence in the field. Evaluating the pace of clinical research, results dissemination, and knowledge uptake in synthesized literature can help establish realistic expectations for the time course of clinical trials research and their relative impact toward influencing clinical practice.
authors.affiliation: Concept Systems, Inc., 136 East State Street, Ithaca, NY 14850-5546, Office of HIV/AIDS Network Coordination, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, E2-112, Seattle, WA 98109-1024 and Division of Clinical Research, NIAID, NIH, 6700B Rockledge Drive, Room 1102, Bethesda, MD 20892-7609.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Rosas
authors.affiliation: Concept Systems, Inc., 136 East State Street, Ithaca, NY 14850-5546, Office of HIV/AIDS Network Coordination, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, E2-112, Seattle, WA 98109-1024 and Division of Clinical Research, NIAID, NIH, 6700B Rockledge Drive, Room 1102, Bethesda, MD 20892-7609.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Schouten
authors.affiliation: Concept Systems, Inc., 136 East State Street, Ithaca, NY 14850-5546, Office of HIV/AIDS Network Coordination, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, E2-112, Seattle, WA 98109-1024 and Division of Clinical Research, NIAID, NIH, 6700B Rockledge Drive, Room 1102, Bethesda, MD 20892-7609.
authors.forename: Marie T
authors.initials: MT
authors.lastname: Cope
authors.affiliation: Concept Systems, Inc., 136 East State Street, Ithaca, NY 14850-5546, Office of HIV/AIDS Network Coordination, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, E2-112, Seattle, WA 98109-1024 and Division of Clinical Research, NIAID, NIH, 6700B Rockledge Drive, Room 1102, Bethesda, MD 20892-7609.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Kagan
keywords: citation milestones; dissemination; scientific output; uptake