title: [Studying in vitro neuroprotective properties of GK-2(h)--a new original mimetic of human nerve growth factor].
abstract: Human nerve growth factor (NGF) mimetic hexamethylenediamide bis-N-monosuccinyl-glicyl-lysine) (GK-2(h)) demonstrates protective activity on immortalized mouse hippocampal cell line HT22 in a concentration up to 10(-13)M against hydrogen peroxide toxicity and in concentration up to 10(-8) M against glutamate toxicity. GK-2(h) dipeptide protects rat PC-12 pheochromocytoma cells in a concentration up to 10(-7) M and protects human neuroblastoma SH-SY5Y cells in a concentration up to 10(-8) against 6-hydroxydofamine-induced damage.
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
authors.forename: S V
authors.initials: SV
authors.lastname: Nikolaev
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D002460:Cell Line; D004151:Dipeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D018716:Molecular Mimicry; D020932:Nerve Growth Factor / Q000737:chemistry*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D016627:Oxidopamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D016716:PC12 Cells; D051381:Rats
chemical_list: D004151:Dipeptides; C502240:NGF protein, human; D018696:Neuroprotective Agents; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D018698:Glutamic Acid; D016627:Oxidopamine; D020932:Nerve Growth Factor; D006861:Hydrogen Peroxide