title: Analysis of pathological data of renal biopsy at one single center in China from 1987 to 2012.
abstract: BACKGROUND
  In China, the prevalence of chronic kidney disease has increased significantly. Many studies shows that the spectrum of kidney disease had changed in recent years. We retrospectively analyzed the pathological types of renal biopsy and its spectrum change at the General Hospital of the Chinese People's Liberation Army from December 1987 to December 2012, in order to offer new supporting evidences for further specifying the distribution of renal pathological types in China.
  
  
  METHODS
  According to the "Revised Protocol for the Histological Typing of Glomerulopathy" (WHO, 1995), pathological diagnosis of renal biopsy was classified, detection rate of each pathological type was summarized (i.e., percentage of total renal biopsy cases), study period was divided at an interval of 5 years, and age-stratified distribution change of main pathological types was analyzed.
  
  
  RESULTS
  The proportion of pathological types in 11 618 cases of renal biopsy was as follows: primary glomerulonephritis (PGN, 70.7%), secondary glomerulonephritis (SGN, 20.7%), tubular-interstitial nephropathy (4.0%), hereditary/rare nephropathy (0.3%), end-stage renal disease (0.9%), and unclassified renal disease (3.3%). Among PGN, there was IgA nephropathy (IgAN, 37.0%), membranous nephropathy (MN, 11.8%), mesangial proliferative glomerulonephritis (MsPGN, 8.9%), minimal change disease (MCD, 6.6%), and focal segmental glomerulosclerosis (3.9%). Among SGN there was lupus nephritis (LN, 5.5%), Henoch-Schönlein purpura glomerulonephritis (5.3%), hepatitis B virus-associated nephritis (HBVAN, 3.03%), diabetic nephropathy (2.2%), and hypertension/malignant hypertension-associated renal damage (1.9%). Pathological data were analyzed from 1987-1992 to 2008-2012 (after age adjustment). Detection rate of IgAN tended to rise (P < 0.001). Detection rates of MN and MCD rose significantly (P < 0.001), but detection rate of MsPGN dropped significantly (P < 0.001). Among SGN, detection rate of HBVAN tended to drop (P < 0.001).
  
  
  CONCLUSIONS
  In China, PGN was the most common glomerulopathy (mostly IgAN), LN was the most common SGN, and detection rate of MN and MCD rose significantly.
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Xueguang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Minxia
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yuansheng
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Guangyan
authors.initials: G
authors.lastname: Cai
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Ribao
authors.initials: R
authors.lastname: Wei
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Qiu
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yuanda
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Suozhu
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Medical Research Center for Kidney Disease (2013BAI09B05), Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email: xmchen301@126.com.
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D055815:Young Adult