title: Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes.
abstract: Interleukin-1β (IL-1β) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1β by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also trigger the secretion of IL-1β by driving the assembly of the caspase-8- and FADD-containing platform known as the ripoptosome.
authors.affiliation: Department of Pathology; Case Western Reserve University School of Medicine; Cleveland, OH USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Antonopoulos
authors.affiliation: Department of Physiology and Biophysics; Case Western Reserve University School of Medicine; Cleveland, OH USA ; Department of Pathology; Case Western Reserve University School of Medicine; Cleveland, OH USA ; Case Comprehensive Cancer Center; Case Western Reserve University School of Medicine; Cleveland, OH USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Dubyak
keywords: IL-1β; caspase-1; caspase-8; chemotherapy; inflammasome; ripoptosome