title: Young individuals with atopic disease and asthma or rhinoconjunctivitis may have clinically relevant contact allergies.
abstract: BACKGROUND
  Children and adolescents with atopic disease who have allergic asthma and/or rhinitis with and without atopic dermatitis may have hidden, clinically relevant contact allergies.
  
  
  OBJECTIVE
  The objective of this study was to survey contact allergies in children and adolescents who had been offered allergen-specific immunotherapy and accepted (exposed)/not accepted (unexposed) such treatment.
  
  
  METHODS
  Thirty-seven exposed and 24 unexposed individuals with atopic disease were patch tested with a standard series supplemented with aluminum chloride hexahydrate, an empty Finn Chamber, and 8 antigen preparations.
  
  
  RESULTS
  In the exposed group, 18 allergies were detected in 13 individuals with atopic disease when excluding reactions to aluminum and antigen preparations, whereas the corresponding figures for the unexposed group were 9 and 6, respectively (non-significant difference). Independent of the allergen-specific immunotherapy, significantly more (P = 0.013) individuals with atopic dermatitis had at least 1 contact allergy. Clinically relevant allergies were represented by sesquiterpene lactone mix, para-tertiary butylphenol-formaldehyde resin, tixocortol pivalate, and colophony.
  
  
  CONCLUSIONS
  Clinically relevant contact allergies are not uncommon in children and adolescents with atopic disease, which is why patch testing always should be considered in the management of dermatitis in individuals with atopic disease.
authors.affiliation: From the *Department of Occupational and Environmental Dermatology, Skåne University Hospital; †Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö; and ‡Department of Paediatrics, County Hospital, Halmstad, Sweden.
authors.forename: Eva
authors.initials: E
authors.lastname: Netterlid
authors.forename: Monica
authors.initials: M
authors.lastname: Hindsén
authors.forename: Susanne
authors.initials: S
authors.lastname: Ekqvist
authors.forename: Kent Ake
authors.initials: KA
authors.lastname: Henricson
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage; D001249:Asthma / Q000453:epidemiology; D002648:Child; D015897:Comorbidity; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology*; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D010328:Patch Tests / Q000706:statistics & numerical data; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000453:epidemiology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000453:epidemiology; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D000485:Allergens