title: Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins.
abstract: Polycomb group (PcG) complexes are epigenetic regulatory complexes that conduct transcriptional repression of target genes via modifying the chromatin. The two best characterized forms of PcG complexes, polycomb repressive complexes 1 and 2 (PRC1 and PRC2), are required for maintaining the stemness of embryonic stem cells and many types of adult stem cells. The spectra of target genes for PRCs are dynamically changing with cell differentiation, which is essential for proper decisions on cell fate during developmental processes. Chromobox (CBX) family proteins are canonical components in PRC1, responsible for targeting PRC1 to the chromatin. Recent studies highlight the function specifications among CBX family members in undifferentiated and differentiated stem cells, which reveal the interplay between compositional diversity and functional specificity of PRC1. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.
authors.affiliation: School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
authors.forename: Rong-gang
authors.initials: RG
authors.lastname: Ma
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics*; D006801:Humans; D063146:Polycomb-Group Proteins / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D002843:Chromatin; D063146:Polycomb-Group Proteins
keywords: Cancer; Chromobox (CBX) protein; Epigenetic regulation; Polycomb; Polycomb repressive complex 1 (PRC1)