title: [Sentinel node invasion: is it necessary to perform axillary lymph node dissection? Randomized trial SERC].
abstract: Contribution of axillary lymph node dissection (ALND) is questioned for positive sentinel node (SN), micro-metastasis and isolated tumor cells but also for macro-metastasis. The aim of this work is to precise why a prospective randomized trial is necessary and the design of this trial. Why? For positive SN, the scientific level evidence appears insufficient for validation of ALND omission as a new standard. Rational is presented with non-sentinel node involved rate and number of NSL involved at complementary ALND, axillary recurrence rate, disease free survival rate and adjuvant treatment decision impact. How? The proposed Sentinelle Envahi et Randomisation du Curage (SERC) trial will randomly assign to observation only or complementary ALND with positive SN. The aim is to demonstrate the non-inferiority of ALND omission versus ALND.
authors.affiliation: Institut Paoli-Calmettes et CRCM 232, boulevard Sainte-Marguerite, 13273 Marseille cedex 9, France, Université Aix-Marseille, 27, bd Jean-Moulin, 13385 Marseille cedex 5, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Houvenaeghel
authors.affiliation: Institut Paoli-Calmettes et CRCM 232, boulevard Sainte-Marguerite, 13273 Marseille cedex 9, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Resbeut
authors.affiliation: Institut Paoli-Calmettes et CRCM 232, boulevard Sainte-Marguerite, 13273 Marseille cedex 9, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Boher
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D061206:Neoplasm Micrometastasis / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies
keywords: axillary lymph node dissection; breast cancer; randomised trial; sentinel node