title: Acute and subacute toxicity study of 1,8-cineole in mice.
abstract: The effects of acute and subacute toxicity of 1,8-cineole in Kunming mice were studied. After acute oral administration, the LD50 value (95% CL) was 3849 mg/kg (3488.8~4247.1 mg/kg). In the subacute toxicity study, there were no significant differences in body weight and relative organ weight between the control group and 1,8-cineole treatment groups. The histopathological examinations showed that granular degeneration and vacuolar degeneration appeared in liver and kidney tissue after administration of high dose of 1,8-cineole. Under electron microscopy, a series of ultrastructural changes were observed: The electron microscopy assays indicated that the influence of 1,8-cineole on the target organ at the subcellular level were mainly on the mitochondria, endoplasmic reticulum and other membrane type structure of liver and kidney.
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China ; Leshan Vocational & Technical College Leshan, 614000, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Xu
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Hu
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Zhong-Qiong
authors.initials: ZQ
authors.lastname: Yin
authors.affiliation: Key Lab of Southwest Special Economic Plant Protection & Utilization, Yibin College Yibin, 644000, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wei
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhou
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Key Lab of Southwest Special Economic Plant Protection & Utilization, Yibin College Yibin, 644000, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Du
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Ren-Yong
authors.initials: RY
authors.lastname: Jia
authors.affiliation: College of Forestry, Sichuan Agricutural University Ya'an, 625014, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Qiao-Jia
authors.initials: QJ
authors.lastname: Fan
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Liang
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Chang-Liang
authors.initials: CL
authors.lastname: He
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University Ya'an, 625014, China.
authors.forename: Li-Zi
authors.initials: LZ
authors.lastname: Yin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003511:Cyclohexanols / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D000077591:Eucalyptol; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D023421:Models, Animal; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D023382:Toxicity Tests, Acute; D059551:Toxicity Tests, Subacute
chemical_list: D003511:Cyclohexanols; D039821:Monoterpenes; D000077591:Eucalyptol
keywords: 1; 8-cineole; histopathology; mice; toxicity; ultrastructural changes