title: [Relationship between warfarin dosing and activity of CYP2C9 assessed by the content of losartan and its metabolite E-3174 in the urine of patients with mechanical prosthetic heart valves].
abstract: We evaluated effect of activity of cytochrome P450 CYP2C9 on maintenance doses of warfarin in 33 patients with implanted artificial heart valves. Losartan test was used for measurement of concentration of active metabolite E-3174 in urine. Concentration of E-3174 below 2500 ng/ml in patients with genotype CYP2C981/*1 with sensitivity 87% and specificity 66% predicted requirement of low doses (< 5 mg/day) of warfarin in the late postoperative period (odds ratio 14, 95% confidence interval 1.135 to 172.75).
authors.forename: S M
authors.initials: SM
authors.lastname: Arslanbekova
authors.forename: D A
authors.initials: DA
authors.lastname: Sychev
authors.forename: R E
authors.initials: RE
authors.lastname: Kazakov
authors.forename: V V
authors.initials: VV
authors.lastname: Smirnov
authors.forename: E V
authors.initials: EV
authors.lastname: Kuznetsova
authors.forename: E Z
authors.initials: EZ
authors.lastname: Golukhova
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000493:pharmacokinetics; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D001711:Biotransformation / Q000235:genetics; D002317:Cardiovascular Agents / Q000493:pharmacokinetics; D065729:Cytochrome P-450 CYP2C9; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D005838:Genotype; D006349:Heart Valve Diseases / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics / Q000652:urine; D019808:Losartan / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011184:Postoperative Period; D013777:Tetrazoles / Q000493:pharmacokinetics / Q000652:urine; D014859:Warfarin / Q000493:pharmacokinetics*
chemical_list: D000925:Anticoagulants; D002317:Cardiovascular Agents; D007093:Imidazoles; D013777:Tetrazoles; D014859:Warfarin; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; C066026:losartan carboxylic acid; D019808:Losartan