title: [Advance in studies on traditional Chinese medicine on Abeta's scavenging effect].
abstract: Aggregation and accumulation of beta-amyloid peptide (Abeta) in brain tissues contribute to the pathogenesis of Alzheimer's disease. Therefore, the promotion of Abeta clearance is one of the key targets for preventing and treatment Alzheimer's disease. Studies proved that some traditional Chinese medicine (TCM) compounds and extracts could impact the activity of degrading enzyme in amyloid peptide, the transport of hemato encephalic barrier and the phagocytosis of microglial cells, promote Abeta clearance, and improve learning and memory of animal models with Alzheimer's disease. In this review, we made an summary for the relations between Abeta and Alzheimer's disease, the Abeta clearance mechanism and the clearance effect of traditional Chinese medicines.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Fu-Kai
authors.initials: FK
authors.lastname: Huang
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Yan
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D055503:Protein Multimerization / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides