title: Involvement of miRNAs in placental alterations mediated by oxidative stress.
abstract: Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, preterm labor, and intrauterine growth restriction. While a considerable number of miRNAs have been related to physiological functions and pathological conditions of the placenta, a direct link among these miRNAs, placental functions, and OS is still lacking. This review summarizes data describing the role of miRNAs in placental pathophysiological processes and their possible impact on OS damaging responses. As miRNAs can be found in circulation, improving our understanding on their role in the pathogenesis of pregnancy related disorders could have an important impact on the diagnosis and prognosis of these diseases.
authors.affiliation: Department of Biomolecular Sciences, University of Urbino, Via Saffi 2, 61029 Urbino, Italy.
authors.forename: Alexander
authors.initials: A
authors.lastname: Rudov
authors.affiliation: Department of Biomolecular Sciences, University of Urbino, Via Saffi 2, 61029 Urbino, Italy.
authors.forename: Walter
authors.identifier: 0000-0001-8438-9559
authors.initials: W
authors.lastname: Balduini
authors.affiliation: Department of Biomolecular Sciences, University of Urbino, Via Saffi 2, 61029 Urbino, Italy.
authors.forename: Silvia
authors.identifier: 0000-0003-3634-3454
authors.initials: S
authors.lastname: Carloni
authors.affiliation: Department of Molecular and Developmental Medicine, University of Siena, Viale Bracci, 36, 53100 Siena, Italy.
authors.forename: Serafina
authors.identifier: 0000-0001-5478-5657
authors.initials: S
authors.lastname: Perrone
authors.affiliation: Department of Molecular and Developmental Medicine, University of Siena, Viale Bracci, 36, 53100 Siena, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Buonocore
authors.affiliation: Department of Biomolecular Sciences, University of Urbino, Via Saffi 2, 61029 Urbino, Italy.
authors.forename: Maria Cristina
authors.identifier: 0000-0003-4549-1475
authors.initials: MC
authors.lastname: Albertini
mesh_terms: D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000378:metabolism; D010920:Placenta / Q000378:metabolism* / Q000503:physiopathology; D010929:Placentation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D017382:Reactive Oxygen Species; D010088:Oxidoreductases