title: Juanlimycins A and B, ansamycin macrodilactams from Streptomyces sp.
abstract: Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. This family has shown a high degree of druggability exemplified by rifamycins, maytansinoids, and geldanamycins. In this study, the isolation of two novel ansamycin macrodilactams with unprecedented features, juanlimycins A (1) and B (2), from Streptomyces sp. LC6 were reported. The structures of 1 and 2 were assigned on the basis of analysis of NMR spectroscopic data and X-ray single crystal diffraction.
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
authors.forename: Juanli
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Qian
authors.forename: Xingkang
authors.initials: X
authors.lastname: Wu
authors.forename: Yanjiao
authors.initials: Y
authors.lastname: Ding
authors.forename: Jianfang
authors.initials: J
authors.lastname: Li
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
mesh_terms: D018360:Crystallography, X-Ray; D047029:Lactams, Macrocyclic / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012294:Rifamycins / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D047029:Lactams, Macrocyclic; D012294:Rifamycins; C000589600:juanlimycin A; C000589601:juanlimycin B