title: Interleukin-10 gene polymorphism (-1082G/A) and allergy to efavirenz in patients infected with human immunodeficiency virus.
abstract: The aim of the present study was to investigate the association between polymorphism in the interleukin-10 gene promoter at position -1082 in human immunodeficiency virus-infected patients who had presented allergic reaction due to efavirenz. The study included 63 patients treated at the Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil. Twenty-one patients who had presented allergic reaction to efavirenz were compared to 42 patients with no allergic reaction following exposure to this drug. Blood samples were collected for DNA extraction and submitted to the restriction fragment length polymorphism - polymerase chain reaction technique. The -1082AA genotype was significantly more frequent in allergic patients as compared to non-allergic patients (p=0.019; χ(2)=5.534; OR=3.625; 95% CI=1.210-10.860). Likewise the allele IL-10 -1082A was identified significantly more often among efavirenz allergic patients than in the non-allergic group (p=0.009; χ(2)=6.787; OR=3.029; 95% CI=1.290-7.111). These findings suggest that the polymorphism in the interleukin-10 gene promoter -1082G/A can be related to the development of allergic reactions to efavirenz.
authors.affiliation: Department of Clinical Analysis and Toxicology, Faculty of Pharmacy, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil. Electronic address: raphaelolrodrigues@gmail.com.
authors.forename: Raphael de Oliveira
authors.initials: Rde O
authors.lastname: Rodrigues
authors.affiliation: Department of Clinical Analysis and Toxicology, Faculty of Pharmacy, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil; Health Sciences Center, Universidade de Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Paulo Germano de
authors.initials: PG
authors.lastname: Carvalho
authors.affiliation: Hospital São José de Doenças Infecciosas, Fortaleza, CE, Brazil.
authors.forename: Erico Antônio Gomes de
authors.initials: EA
authors.lastname: Arruda
authors.affiliation: Laboratory of Molecular Genetics, Department of Pathology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
authors.forename: Silvia Helena Barem
authors.initials: SH
authors.lastname: Rabenhorst
authors.affiliation: Health Sciences Center, Universidade de Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Silvia Fernandes Ribeiro da
authors.initials: SF
authors.lastname: Silva
authors.affiliation: Laboratory of Histocompatibility and Transplantation Immunology, Research Center in Hepatorenal Diseases, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
authors.forename: Ilana Farias
authors.initials: IF
authors.lastname: Ribeiro
authors.affiliation: Hospital São José de Doenças Infecciosas, Fortaleza, CE, Brazil.
authors.forename: Denise Girão Limaverde
authors.initials: DG
authors.lastname: Lima
authors.affiliation: Department of Clinical Analysis and Toxicology, Faculty of Pharmacy, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
authors.forename: Aparecida Tiemi
authors.initials: AT
authors.lastname: Nagao-Dias
mesh_terms: D000328:Adult; D000368:Aged; D000480:Alkynes; D048588:Benzoxazines / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D003521:Cyclopropanes; D004342:Drug Hypersensitivity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D018894:Reverse Transcriptase Inhibitors; D016753:Interleukin-10; C098320:efavirenz
keywords: Drug allergy; HIV; IL-10; Polymorphism