title: Cerebral Baylisascaris larva migrans in a cynomolgus macaque (Macaca fascicularis).
abstract: An incidental, asymptomatic, focal inflammatory lesion was detected in brain cerebrum of an approximately 6-year-old, female cynomolgus macaque from a chronic toxicology study. No gross lesions were noted at necropsy. Microscopically, the lesion contained a cross-section of larvae approximately 70-80 μm in diameter, a centrally located intestine flanked on either side by large triangular excretory columns, and prominent single lateral cuticular alae. Mixed inflammatory cells of eosinophils, macrophages, and lymphocytes admixed with abundant connective tissue stroma and necrosis surrounded the larvae. Histochemical stains for trichrome revealed significant amount of fibrous connective tissue. The morphology of the larvae was compatible with Baylisascaris spp. Based on the microscopic and histochemical examination, a diagnosis of neural Baylisascaris spp. larva migrans was made.
authors.affiliation: Pfizer Drug Safety Research and Development, 455 Eastern Point Road, MS 8274-1221, Building 274, Office 1703F, Groton, CT 06340, USA. Electronic address: amshoieb@yahoo.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Shoieb
authors.affiliation: Pfizer Worldwide Research and Development, Drug Safety R&D, Andover, MA, USA. Electronic address: Zaher.Radi@Pfizer.com.
authors.forename: Zaher A
authors.initials: ZA
authors.lastname: Radi
mesh_terms: D000818:Animals; D017191:Ascaridida Infections / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D001199:Ascaridoidea / Q000302:isolation & purification*; D001921:Brain / Q000469:parasitology* / Q000473:pathology; D005260:Female; D006374:Helminthiasis, Animal / Q000469:parasitology* / Q000473:pathology; D007815:Larva Migrans / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000469:parasitology* / Q000473:pathology; D018675:Toxicity Tests / Q000662:veterinary
keywords: Baylisascaris spp.; Cynomolgus macaque; Histopathology