title: Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization.
abstract: Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loading capacity and efficiency is described. We performed experimental and computational studies in order to evaluate the trapping efficiencies, maximum loading capacity and magnetic alignment of the nanoparticles. The results showed that capacity and trapping efficiencies are directly related to the flow rate, elution time and reactor type. Based on our results and the developed magnetic microreactor, we describe a model multistep surface derivatization procedure of SPIONs.
authors.affiliation: Adolphe Merkle Institute, University of Fribourg, Route de l'ancienne papeterie CP 209, CH-1723 Marly 1, Switzerland. alke.fink@unifr.ch.
authors.forename: R G
authors.initials: RG
authors.lastname: Digigow
authors.forename: J-F
authors.initials: JF
authors.lastname: Dechézelles
authors.forename: J
authors.initials: J
authors.lastname: Kaufmann
authors.forename: D
authors.initials: D
authors.lastname: Vanhecke
authors.forename: H
authors.initials: H
authors.lastname: Knapp
authors.forename: M
authors.initials: M
authors.lastname: Lattuada
authors.forename: B
authors.initials: B
authors.lastname: Rothen-Rutishauser
authors.forename: A
authors.initials: A
authors.lastname: Petri-Fink
mesh_terms: D019149:Bioreactors; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012212:Rheology / Q000295:instrumentation / Q000379:methods
chemical_list: D058185:Magnetite Nanoparticles