title: Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.
abstract: Veteran populations are exposed to multiple stressful events, and suicidality among veterans is a serious problem. Identifying biomarkers of suicidality may enhance detection, prevention, and treatment. Multiple neurotransmitter systems are implicated in the neurobiology of suicidality, including amino acid neurotransmitter systems. Amino acids as biomarker candidates for suicidality were quantified using mass spectrometry in serum samples from 90 male U.S. Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans. Amino acid levels in veterans reporting suicidal ideation (SI) on the Beck Scale for Suicidal Ideation (BSS) (BSS score > 0, n = 19) were compared with those reporting no SI (BSS score = 0, n = 71). Glycine, an excitatory amino acid and N-methyl-d-aspartate receptor modulator, was significantly elevated in serum samples from veterans reporting SI (p = 0.043). Serine and aspartate/asparagine, also excitatory neurotransmitters, were nonsignificantly increased in veterans reporting SI (p = 0.082 and p = 0.097, respectively). In contrast, arginine (nitric oxide [NO] precursor) and citrulline (by-product of NO formation) were nonsignificantly decreased in veterans reporting SI (p = 0.097 and p = 0.093, respectively). Profiling amino acids as possible biomarker candidates for suicidality in OEF/OIF veterans may have clinical utility for identifying suicidal risk. Glutamatergic neurotransmission and NO signaling may be relevant to the neurobiology of suicidality in OEF/OIF veterans.
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Szabo
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Kilts
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Naylor
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Nagy A
authors.initials: NA
authors.lastname: Youssef
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Strauss
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Rajendra A
authors.initials: RA
authors.lastname: Morey
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Mira
authors.initials: M
authors.lastname: Brancu
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hamer
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Bradford
authors.affiliation: Durham Veterans Affairs Medical Center and VA Mid-Atlantic MIRECC, 508 Fulton Street, Mental Health Service Line (116A), Durham, NC 27705.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Marx
mesh_terms: D055826:Afghan Campaign 2001-; D000596:Amino Acids; D001120:Arginine / Q000097:blood; D002956:Citrulline / Q000097:blood; D006801:Humans; D054542:Iraq War, 2003-2011; D008297:Male; D010865:Pilot Projects; D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine / Q000097:blood; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology; D059020:Suicidal Ideation; D014728:Veterans / Q000523:psychology / Q000706:statistics & numerical data
chemical_list: D000596:Amino Acids; D016194:Receptors, N-Methyl-D-Aspartate; D002956:Citrulline; D012694:Serine; D001120:Arginine