title: Physical properties and biocompatibility of UHMWPE-derived materials modified by synchrotron radiation.
abstract: The applications of synchrotron radiation (SR) in medical imaging have become of great use, particularly in angiography, bronchography, mammography, computed tomography, and X-ray microscopy. Thanks to recently developed phase contrast imaging techniques non-destructive preclinical testing of low absorbing materials such as polymers has become possible. The focus of the present work is characterization and examination of UHMWPE-derived materials widely used in medicine, before and after their exposure to SR during such testing. Physical properties, such as wettability, surface energy, IR-spectroscopy, roughness, optical microscopy, microhardness measurements of UHMWPE samples were studied before and after SR. The relationship between a growth of UHMWPE surface hydrophilicity after SR and surface colonization by stromal cells was studied in vitro. Obtained results demonstrate that SR may be used as prospective direction to examine bulk (porous) structure of polymer materials and/or to modify polymer surface and volume for tissue engineering.
authors.affiliation: Tomsk Polytechnic University, Lenin Ave. 30, 634050, Tomsk, Russia, yuliavb@tpu.ru.
authors.forename: Iu
authors.initials: Iu
authors.lastname: Bykova
authors.forename: V
authors.initials: V
authors.lastname: Weinhardt
authors.forename: A
authors.initials: A
authors.lastname: Kashkarova
authors.forename: S
authors.initials: S
authors.lastname: Lebedev
authors.forename: T
authors.initials: T
authors.lastname: Baumbach
authors.forename: V
authors.initials: V
authors.lastname: Pichugin
authors.forename: K
authors.initials: K
authors.lastname: Zaitsev
authors.forename: I
authors.initials: I
authors.lastname: Khlusov
mesh_terms: D001672:Biocompatible Materials; D018625:Microscopy, Atomic Force; D011095:Polyethylenes / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D017356:Synchrotrons; D017155:Wettability
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene