title: Novel diagnostics and therapeutics for drug-resistant tuberculosis.
abstract: BACKGROUND
  Drug-resistant tuberculosis (DR-TB) is associated with increased mortality and morbidity. This is at least partly due to late diagnosis and ineffective treatment of drug-resistant status.
  
  
  METHODS
  Selective search of the literature on DR-TB supplemented by recent guidelines from the World Health Organization.
  
  
  RESULTS
  Better and more rapid diagnosis of DR-TB by new techniques such as Xpert Mtb/RIF are likely to make a substantial impact on the disease. New therapeutics for DR-TB are entering, or about to enter the market for the first time in decades.
  
  
  RESULTS
  It is not clear whether new treatments should be restricted for DR-TB or also used for drug-susceptible tuberculosis.
  
  
  CONCLUSIONS
  With several new agents on the horizon, there is the real possibility of an entirely new regimen for tuberculosis.
  
  
  CONCLUSIONS
  An inexpensive 'near-patient' diagnostic test is still needed. Optimizing new drug combination regimens in a timely manner is urgently required.
authors.affiliation: Centre for Infectious Diseases Research, Tsinghua University School of Medicine, Beijing, China.
authors.forename: Melody
authors.initials: M
authors.lastname: Toosky
authors.affiliation: Centre for Infectious Diseases Research, Tsinghua University School of Medicine, Beijing, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Hangzhou, China Department of Medicine, University of Cambridge, Cambridge, UK bjavid@gmail.com.
authors.forename: Babak
authors.initials: B
authors.lastname: Javid
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents
keywords: MDR-TB; XDR-TB; diagnostics; drug-resistant tuberculosis; new antibiotics