title: Atherosclerosis, some serum inflammatory markers in psoriasis.
abstract: OBJECTIVE
  Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers.
  
  
  METHODS
  We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glycoprotein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done.
  
  
  RESULTS
  Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, β-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (β±SE: -2.055±0.861, P=0.019) and β-stiffness index (β±SE: 2.934±1.143, P=0.012).
  
  
  CONCLUSIONS
  Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the β-stiffness index.
authors.affiliation: Department of Cardiology, Faculty of Medicine Namık Kemal University, Tekirdag, Turkey - serefalpsoy@hotmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Alpsoy
authors.forename: A
authors.initials: A
authors.lastname: Akyuz
authors.forename: G
authors.initials: G
authors.lastname: Erfan
authors.forename: D C
authors.initials: DC
authors.lastname: Akkoyun
authors.forename: B
authors.initials: B
authors.lastname: Topcu
authors.forename: S
authors.initials: S
authors.lastname: Guzel
authors.forename: S
authors.initials: S
authors.lastname: Kaya
authors.forename: M
authors.initials: M
authors.lastname: Kulac
mesh_terms: D054392:Adipokines / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D001011:Aorta / Q000503:physiopathology; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D015415:Biomarkers; D001772:Blood Cell Count; D002097:C-Reactive Protein / Q000032:analysis; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D015897:Comorbidity; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology; D037102:Lectins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology; D014655:Vascular Resistance; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D003176:Complement C3; D003181:Complement C4; D005338:Fibrin Fibrinogen Degradation Products; D037102:Lectins; C036309:fibrin fragment D; D005340:Fibrinogen; D002097:C-Reactive Protein