title: Preparation and enantioselectivity binding studies of a new chiral cobalt(II)porphyrin-Tröger's base conjugate.
abstract: A new bis[cobalt(II)porphyrin]-Tröger's base conjugate was studied as a potential receptor for methyl esters of several amino acids. The conjugate was prepared as racemate, and then resolved via preparative high-performance liquid chromatography (HPLC) on a chiral column. The high affinity to lysine, histidine, and proline methyl esters was found by complexation studies followed by UV-Vis spectroscopy. The studies of pure enantiomers, followed by UV-Vis and electronic circular dichroism spectroscopy, revealed the highest enantioselectivity for lysine methyl ester.
authors.affiliation: Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic.
authors.forename: Ameneh
authors.initials: A
authors.lastname: Tatar
authors.forename: Martin
authors.initials: M
authors.lastname: Valík
authors.forename: Jana
authors.initials: J
authors.lastname: Novotná
authors.forename: Martin
authors.initials: M
authors.lastname: Havlík
authors.forename: Bohumil
authors.initials: B
authors.lastname: Dolenský
authors.forename: Vladimír
authors.initials: V
authors.lastname: Král
authors.forename: Marie
authors.initials: M
authors.lastname: Urbanová
keywords: Tröger's base conjugate; chiral receptors; enantioselectivity