title: [In vitro metabolism of fenbendazole prodrug].
abstract: Synthesized fenbendazole prodrug N-methoxycarbonyl-N'-(2-nitro-4-phenylthiophenyl) thiourea (MPT) was analyzed in vitro in artificial gastric juice, intestinal juice and mouse liver homogenate model by using HPLC method, and metabolic curve was then generated. MPT was tested against Echinococcus granulosus protoscolices in vitro. The result showed that MPT could be metabolized in the three biological media, and to the active compound fenbendazole in liver homogenate, with a metabolic rate of 7.92%. Besides, the prodrug showed a weak activity against E. granulosus protoscolices with a mortality of 45.9%.
authors.forename: Ai-Dan
authors.initials: AD
authors.lastname: Wen
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Duan
authors.forename: Cong-Shan
authors.initials: CS
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Tao
authors.forename: Jian
authors.initials: J
authors.lastname: Xue
authors.forename: Ning-Bo
authors.initials: NB
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.forename: Hao-Bing
authors.initials: HB
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000378:metabolism*; D004195:Disease Models, Animal; D048209:Echinococcus granulosus / Q000187:drug effects; D005260:Female; D005273:Fenbendazole / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011355:Prodrugs / Q000493:pharmacokinetics*
chemical_list: D011355:Prodrugs; D005273:Fenbendazole