title: Dammarane-type triterpenoids from Gentianella azurea.
abstract: Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallographic data. This is the first report of dammarane-type triterpenoids in the Gentianella genus. In addition, the known structures of gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17) were revised based on the X-ray diffraction analysis. Gentirigeoside A (15) was found to inhibit nitric oxide production in RAW 264.7 macrophages with an IC50 value of 6.6 ± 2.1 μM.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
authors.forename: Xue-li
authors.initials: XL
authors.lastname: Yu
authors.forename: Shu-wei
authors.initials: SW
authors.lastname: Zhang
authors.forename: Wen-qiong
authors.initials: WQ
authors.lastname: Wang
authors.forename: Lin-yin
authors.initials: LY
authors.lastname: Fen
authors.forename: Li-jiang
authors.initials: LJ
authors.lastname: Xuan
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031313:Gentianella / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D014315:Triterpenes; D000097669:Dammaranes