title: Synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(II) complexes.
abstract: Two new Ru(II) complexes, [Ru(bpy)2(FAMP)](ClO4)2 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and 1H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: School of Food Science, Guangdong Pharmaceutical University, Zhongshan, P. R. China.
authors.forename: Nan-Jing
authors.initials: NJ
authors.lastname: Zhong
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, P. R. China.
authors.forename: Yang-Yin
authors.initials: YY
authors.lastname: Xie
authors.affiliation: School of Life Science and Biopharmaceutical, Guangdong Pharmaceutical University, Guangzhou, P. R. China.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Huang
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, P. R. China.
authors.forename: Guang-Bin
authors.initials: GB
authors.lastname: Jiang
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, P. R. China.
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D009942:Organometallic Compounds; D012428:Ruthenium