title: Detection of mutation-specific epidermal growth factor receptor (E746-A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma.
abstract: The clinical impact of epidermal growth factor receptor (EGFR) (E746-A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR (E746-A750del) expression was analyzed in OSCC specimens (n=161) by immunohistochemistry. The expression results were correlated with clinical characteristics and impact on survival. Using INNO-LiPA Extra, high-risk HPV types were genotyped and analyzed in 211 OSCC specimens. Positive EGFR (E746-A750del) expression (n=40/161, 25%) was not associated with any clinicopathological characteristics, prognostic factors, social habits (smoking, alcohol consumption), or tumour-specific survival. HPV16 DNA was detected in three out of 211 samples (HPV16-positive: n=3/211, 1.4%). This study shows that mutation-specific EGFR (E746-A750del) expression and HPV do not appear to be relevant to the survival of patients with OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany. Electronic address: dr.dr.martingrimm@googlemail.com.
authors.forename: M
authors.initials: M
authors.lastname: Grimm
authors.affiliation: Medical Virology, Division of Experimental Virology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Iftner
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Altaki
authors.affiliation: Medical Virology, Division of Experimental Virology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Iftner
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany.
authors.forename: J P
authors.initials: JP
authors.lastname: Peters
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Munz
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Reinert
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000821:virology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000821:virology; D009154:Mutation; D027383:Papillomaviridae / Q000302:isolation & purification; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D066246:ErbB Receptors
keywords: human papillomavirus.; mutant epidermal growth factor receptor; oral squamous cell carcinoma