title: Aliphatic phenolic ethers from Trichobotrys effusa.
abstract: Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).
authors.affiliation: Department of Pharmacy, Tajen University , Pingtung, Taiwan 907.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Wang
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Hsiao
authors.forename: Ming-Shian
authors.initials: MS
authors.lastname: Lee
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Ju
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Tzong-Huei
authors.initials: TH
authors.lastname: Lee
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004987:Ethers; D018942:Macrolides; D010636:Phenols; C035359:monorden; D005472:Fluorouracil