title: A review on proniosomal drug delivery system for targeted drug action.
abstract: Proniosomes are dry formulation of water soluble carrier particles that are coated with surfactant. They are rehydrated to form niosomal dispersion immediately before use on agitation in hot aqueous media within minutes. Proniosomes are physically stable during the storage and transport. Drug encapsulated in the vesicular structure of proniosomes prolong the existence of drug in the systematic circulation and enhances the penetration into target tissue and reduce toxicity. From a technical point of view, niosomes are promising drug carriers as they possess greater chemical stability and lack of many disadvantages associated with liposomes, such as high- cost and variable purity problems of phospholipids. The present review emphasizes on overall methods of preparation characterization and applicability of proniosomes in targeted drug action.
authors.affiliation: Department of Pharmaceutics, Gandhi Institute of Technology and Management, Institute of Pharmacy, Gandhi Institute of Technology and Management University, Rushikonda, Visakhapatnam, Andhra Pradesh, India.
authors.forename: G V
authors.initials: GV
authors.lastname: Radha
authors.affiliation: Department of Pharmaceutics, Gandhi Institute of Technology and Management, Institute of Pharmacy, Gandhi Institute of Technology and Management University, Rushikonda, Visakhapatnam, Andhra Pradesh, India.
authors.forename: T Sudha
authors.initials: TS
authors.lastname: Rani
authors.affiliation: Department of Pharmaceutics, Gandhi Institute of Technology and Management, Institute of Pharmacy, Gandhi Institute of Technology and Management University, Rushikonda, Visakhapatnam, Andhra Pradesh, India.
authors.forename: B
authors.initials: B
authors.lastname: Sarvani
keywords: Characterization; clinical applications; niosomes; proniosomes; targeted drug action