title: [Correlation of NOS1AP gene polymorphisms with sudden unexpected death in Chinese Han population].
abstract: OBJECTIVE
  To investigate the single nucleotide polymorphism of NOS1AP gene with sudden unexpected death (SUD) during daily activities.
  
  
  METHODS
  The heart blood samples were collected from 60 SUD cases in normal daily activities as SUD group and the peripheral blood samples from 80 random unrelated cases as control group. The genome DNAs from all cases were isolated and the gene sequences were analyzed from specific primers of some SNP (rs10494366, rs10918859, rs12143842, rs12742393, rs3751284, and rs348624) of NOS1AP. The allele frequency and genotype frequency were calculated and the difference in these SNP between SUD group and control group were analyzed.
  
  
  RESULTS
  The allele frequency and genotype frequency of rs3751284 which located at the sixth exon domain had significant statistical differences between the two groups (P<0.05). The minor allele frequency of rs3751284 was 0.325 in SUD group and was 0.475 in control group.
  
  
  CONCLUSIONS
  rs3751284 might be a susceptibility locus for SUD.
authors.forename: Jing-Lu
authors.initials: JL
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Hao
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Quan
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Sheng
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D003645:Death, Sudden; D005091:Exons; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C488081:NOS1AP protein, human