title: Sunitinib re-challenge in advanced renal-cell carcinoma.
abstract: Despite offering significant clinical benefits in advanced renal-cell carcinoma (RCC), the effectiveness of targeted therapies eventually declines with the development of resistance. Defining optimal sequences of therapy is therefore the focus of much current research. There is also evidence that treatment 're-challenge' may be an effective strategy in some patients. We review evidence to evaluate whether sunitinib may have value as re-challenge therapy in patients who have progressed on prior targeted therapy with sunitinib and/or an alternative tyrosine kinase inhibitor or mammalian target of rapamycin inhibitor. Re-challenge with sunitinib appears to be of clinical benefit, thus representing a feasible therapeutic option for patients with advanced RCC who are refractory to other treatments and are able to receive further therapy. These observations support hypotheses that resistance to targeted agents is transient and can be at least partially reversed by re-introduction of the same agent after a treatment break. Median progression-free survival durations appear to be shorter and response rates lower on re-challenge than following initial treatment, although a wider interval between treatments appears to increase response to sunitinib re-challenge.
authors.affiliation: 1] Medical Oncology, IRCCS San Matteo University Hospital Foundation, Piazzale C Golgi 19, 27100 Pavia, Italy [2] Italian Nephro-Oncology Group/Gruppo Italiano di Oncologia Nefrologica (GION), Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Porta
authors.affiliation: 1] Medical Oncology, IRCCS San Matteo University Hospital Foundation, Piazzale C Golgi 19, 27100 Pavia, Italy [2] Italian Nephro-Oncology Group/Gruppo Italiano di Oncologia Nefrologica (GION), Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Paglino
authors.affiliation: Department of Haematology, Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Grünwald
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011758:Pyrroles / Q000627:therapeutic use*; D019233:Retreatment; D000077210:Sunitinib; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; D058570:TOR Serine-Threonine Kinases; D000077210:Sunitinib