title: Intraperitoneal curcumin decreased lung, renal and heart injury in abdominal aorta ischemia/reperfusion model in rat.
abstract: BACKGROUND
  Previous studies have demonstrated that curcumin (CUR) has protective effects against ischemia reperfusion injury to various organs. We aimed to determine whether CUR has favorable effects on tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury.
  
  
  METHODS
  Thirty rats were divided into three groups as sham, control and treatment (CUR) group. Control and CUR groups underwent abdominal aorta ischemia for 60 min followed by a 120 min period of reperfusion. In the CUR group, CUR was given 5 min before reperfusion at a dose of 200 mg/kg via an intraperitoneal route. Total antioxidant capacity (TAC), total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured, and lung, renal and heart tissue histopathology were evaluated with light microscopy.
  
  
  RESULTS
  TOS and OSI activity in blood samples were statistically decreased in sham and CUR groups compared to the control group (p < 0.001 for TOS and OSI). Renal, lung, heart injury scores of sham and CUR groups were statistically decreased compared to control group (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in CUR group than in the control group.
  
  
  CONCLUSIONS
  CUR administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta I/R rat model.
authors.affiliation: Harran University Faculty of Medicine, Department of Cardiovascular Surgery, Sanliurfa, Turkey. Electronic address: drmsalihaydin@harran.edu.tr.
authors.forename: Mehmet Salih
authors.initials: MS
authors.lastname: Aydin
authors.affiliation: Dicle University Faculty of Medicine, Department of Cardiovascular Surgery, Diyarbakır, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Caliskan
authors.affiliation: Harran University Faculty of Medicine, Department of Cardiovascular Surgery, Sanliurfa, Turkey.
authors.forename: Aydemir
authors.initials: A
authors.lastname: Kocarslan
authors.affiliation: Harran University Medical Faculty, Department of Pathology, Sanliurfa, Turkey.
authors.forename: Sezen
authors.initials: S
authors.lastname: Kocarslan
authors.affiliation: Harran University Medical Faculty, Department of Cardiology, Sanliurfa, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Harran University Medical Faculty, Department of Thoracic Surgery, Sanliurfa, Turkey.
authors.forename: Samil
authors.initials: S
authors.lastname: Günay
authors.affiliation: Harran University Medical Faculty, Department of Biochemistry, Sanliurfa, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Savik
authors.affiliation: Harran University Faculty of Medicine, Department of Cardiovascular Surgery, Sanliurfa, Turkey.
authors.forename: Abdussemet
authors.initials: A
authors.lastname: Hazar
authors.affiliation: Harran University Medical Faculty, Department of Biochemistry, Sanliurfa, Turkey; Harran University Medical Faculty, Department of Chest Disease, Sanliurfa, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Yalcin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001012:Aorta, Abdominal; D003331:Coronary Vessels / Q000473:pathology; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D003474:Curcumin
keywords: Abdominal aorta; Curcumin; Ischemia reperfusion; Oxidative status