title: Evaluation of protective effect of myricetin, a bioflavonoid in dimethyl benzanthracene-induced breast cancer in female Wistar rats.
abstract: BACKGROUND
  Breast cancer is one of the most common cancers worldwide. Alarmingly, the incidence of breast cancer is rising rapidly in India.
  
  
  OBJECTIVE
  The present research was focused to assess the role of myricetin; a bioflavonoid in 7,12-dimethylbenzanthracene (DMBA)-induced breast cancer in female Wistar rats.
  
  
  METHODS
  A total of 36 female Wistar rats (total 6 groups, n = 6 per group) 6 - 8 weeks old, weighing 150 gm were used in the study. DMBA was given at the dose of 7.5 mg/kg subcutaneously in the mammary region once a week for 4 consecutive weeks in group 2. Vincristine was given in the dose of 500 μg/kg intraperitonially every week for 4 consecutive weeks in group 3. Myricetin was given orally in a dose of 50, 100, and 200 mg/kg in group 4, 5, and 6 respectively. The statistical significance of the data was determined using one way analysis of variance and Duncan's multiple range test.
  
  
  RESULTS
  The result showed that myricetin increased the antioxidant levels in plasma, erythrocyte lysate, and breast tissue and was effective in preventing the oxidative damage induced by the carcinogen DMBA. Myricetin 50, 100, and 200 mg/kg/oral for 120 days treated animal resulted comparable results to that of standard vincristine and control groups.
  
  
  CONCLUSIONS
  Myricetin was found to be either equieffective or more effective than vincristine in all the parameters studied. Myricetin proved the capacity of flavonols to act as antioxidant in cells represents a potential treatment in the field of oncology.
authors.affiliation: Department of Pharmacology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.
authors.forename: J K
authors.initials: JK
authors.lastname: Jayakumar
authors.affiliation: Department of Pharmacology, Rajah Muthiah Medical College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Nirmala
authors.affiliation: Department of Community Medicine, Peoples Education Society's Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India.
authors.forename: B A
authors.initials: BA
authors.lastname: Praveen Kumar
authors.affiliation: Department of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India.
authors.forename: Ashok P
authors.initials: AP
authors.lastname: Kumar
keywords: 7,12-dimethylbenzanthracene; Anti oxidants; breast cancer; dimethyl benzanthracene; myricetin; vincristine