title: Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene?
abstract: The Tumor protein D52 (TPD52) gene was identified nearly 20 years ago through its overexpression in human cancer, and a substantial body of data now strongly supports TPD52 representing a gene amplification target at chromosome 8q21.13. This review updates progress toward understanding the significance of TPD52 overexpression and targeting, both in tumors known to be characterized by TPD52 overexpression/amplification, and those where TPD52 overexpression/amplification has been recently or variably reported. We highlight recent findings supporting microRNA regulation of TPD52 expression in experimental systems and describe progress toward deciphering TPD52's cellular functions, particularly in cancer cells. Finally, we provide an overview of TPD52's potential as a cancer biomarker and immunotherapeutic target. These combined studies highlight the potential value of genes such as TPD52, which are overexpressed in many cancer types, but have been relatively understudied.
authors.affiliation: Molecular Oncology Laboratory, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, 2145, NSW, Australia, jennifer.byrne@health.nsw.gov.au.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Byrne
authors.forename: Sarah
authors.initials: S
authors.lastname: Frost
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Chen
authors.forename: Robert K
authors.initials: RK
authors.lastname: Bright
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D045744:Cell Line, Tumor; D002470:Cell Survival; D002898:Chromosomes, Human, Pair 8; D004249:DNA Damage; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D009154:Mutation; D009363:Neoplasm Proteins / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D009857:Oncogenes; D014611:Vaccination
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D009363:Neoplasm Proteins; C114751:TPD52 protein, human