title: The lock-washer: a reconciliation of the RIG-I activation models.
abstract: RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-linked ubiquitin chains, uncovering its activation mechanism for downstream signaling.
authors.affiliation: Department of Immunobiology, Yale University New Haven, CT 06520, USA.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Immunobiology, Yale University New Haven, CT 06520, USA.
authors.forename: Ruaidhri
authors.initials: R
authors.lastname: Jackson
authors.affiliation: 1] Department of Immunobiology, Yale University New Haven, CT 06520, USA [2] Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D053487:DEAD-box RNA Helicases / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D025801:Ubiquitin / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D053487:DEAD-box RNA Helicases