title: [Transcriptional regulation by silence information regulator 2].
abstract: Silence information regulator 2 (Sir2) family is a group of conserved deacetylases, widely existed in organisms from archaea to mammals, and characterized by NAD(+)-dependent deacetylase and ADP-ribosyltransferase activities. Sir2 plays an important role in various life progresses, such as chromatin silence, gene regulation, metabolic regulation, life span of cells and so on. Through its deacetylase activity and/or interaction with other proteins, Sir2 can regulate chromatin structure or modify transcription related factors, thus regulating the transcriptional process. This article emphasizes on the progress of Sir2-dependent regulation of gene transcription.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Ju
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Li
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D056565:Sirtuin 2 / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D056565:Sirtuin 2