title: Different long-term outcomes of abdominal aortic aneurysm and intracranial aneurysm models: hemodynamic change may also play an essential role in the initiation and progression of abdominal aortic aneurysm in rabbits.
abstract: Self-healing phenomenon was found in the periarterial elastase-induced abdominal aortic aneurysm (AAA) in rabbit. This kind of aneurysm model does not progress and heals spontaneously in the long term, which is quite different from the performance of AAA disease in human. In order to better mimic human AAA and overcome this shortcoming of traditional AAA model in rabbit, we studied the pathogenesis of cerebral aneurysm (CA) model in small animal, which shows an excellent long-term patency and progressive enlargement. We found that hemodynamic conditions, such as turbulence flow, high blood flow, and shear stress, play an important role in the formation and progression of CA. So, we hypothesize that hemodynamic change may also play an essential role in the initiation and progression of rabbit AAA, and self-healing will be overcome if hemodynamic condition changes by coarctation of infra-renal aorta after elastase incubation.
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Bi
authors.forename: Xinwei
authors.initials: X
authors.lastname: Han
authors.forename: Hongshan
authors.initials: H
authors.lastname: Zhong
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Xun
authors.initials: X
authors.lastname: Qi
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Weixiao
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006439:Hemodynamics; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D011379:Prognosis; D011817:Rabbits; D013997:Time Factors