title: Is TNF-α gene polymorphism related to pulmonary functions and prognosis as determined by FEV1, BMI, COPD exacerbation and hospitalization in patients with smoking-related COPD in a Turkish population?
abstract: BACKGROUND
  Some conflicting results have been published about the relationship between TNF-α-308 gene polymorphism and chronic obstructive pulmonary disease (COPD). The aim of this study was to determine whether TNF-α-308 gene polymorphism was associated with smoking-related COPD and whether it was associated with pulmonary function parameters (PFTs), body mass index (BMI), and prognosis.
  
  
  METHODS
  We studied the frequencies of TNF-α-308 gene polymorphism in 90 male subjects (60 subjects with COPD and 30 healthy smokers) in a Caucasian population.
  
  
  RESULTS
  There was no significant difference in the frequency of G/G and G/A gene polymorphisms in the COPD group compared with control subjects (p>0.05). We compared COPD patients as G/A gene polymorphism and G/G gene polymorphism; the PFTs and BMI before and after one year were not statistically significant (p>0.05). Also, the exacerbation and hospitalization data of COPD patients were not significant between these groups.
  
  
  CONCLUSIONS
  In conclusion, there was no difference between smoking-related COPD and the control group according to TNF α-308 gene polymorphism in a Caucasian population. In addition, it was shown that important determinants of prognosis of COPD such as FEV1, BMI, COPD exacerbation and hospitalization were not associated with TNF-α-308 gene polymorphism.
authors.affiliation: Department of Pulmonary Medicine, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Nezihe
authors.initials: N
authors.lastname: Özdoğan
authors.affiliation: Department of Pulmonary Medicine, Erciyes University School of Medicine, Kayseri, Turkey. Electronic address: drnuritutar@gmail.com.
authors.forename: Nuri
authors.initials: N
authors.lastname: Tutar
authors.affiliation: Department of Pulmonary Medicine, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Demir
authors.affiliation: Department of Genetics, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Çetin
authors.initials: Ç
authors.lastname: Saatçi
authors.affiliation: Department of Pulmonary Medicine, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Asiye
authors.initials: A
authors.lastname: Kanbay
authors.affiliation: Department of Pulmonary Medicine, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Büyükoğlan
mesh_terms: D015992:Body Mass Index; D018450:Disease Progression; D005541:Forced Expiratory Volume; D006760:Hospitalization; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014421:Turkey
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Chronic obstructive pulmonary disease; Doença pulmonar obstrutiva crónica; Factor de necrose tumoral alfa; Genetics; Genética; Polimorfismo; Polymorphism; Tumor necrosis factor-α