title: The mediating role of depression in the relationship between anxiety sensitivity and alcohol dependence.
abstract: BACKGROUND
  Many studies have reported that Anxiety Sensitivity (AS) is positively associated with alcohol use or other alcohol-related variables. More recent mediator and moderator models have shown promise in elucidating mechanisms within this relationship; the literature to date suggests that the relationship between AS and alcohol is likely mediated by problematic coping motives. However, few studies have considered the effects of depression within the AS-alcohol use relationship, despite a strong body of evidence linking AS to subsequent depression and depression to subsequent alcohol use problems, independently. Therefore, the current study assessed depression as a potential mediator of this relationship.
  
  
  METHODS
  Participants were 418 sequential admissions to a substance abuse treatment facility. A mediation analysis using bootstrapping was utilized in order to estimate indirect effects of AS on alcohol dependence through depression.
  
  
  RESULTS
  Results reveal an indirect effect suggesting that the effects of anxiety sensitivity on alcohol dependence are mediated by symptoms of depression. More specifically, the effects of AS total score and AS somatic sensations on alcohol dependence were mediated by symptoms of depression. Lastly, a dual mediator model demonstrated that both depression and problematic coping uniquely mediate the relationship between AS and alcohol dependence.
  
  
  CONCLUSIONS
  While preliminary in nature, the current study provides evidence supporting the hypothesis that depression is an important factor to consider when examining the relationship between AS and alcohol dependence.
authors.affiliation: Oklahoma State University, 118 North Murray Hall, Stillwater, OK 74075, United States; Center for Addictions, Personality, and Emotion Research, University of Maryland, College Park, MD 20742, United States. Electronic address: william.lechner@okstate.edu.
authors.forename: William V
authors.initials: WV
authors.lastname: Lechner
authors.affiliation: Center for Addictions, Personality, and Emotion Research, University of Maryland, College Park, MD 20742, United States.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Shadur
authors.affiliation: Center for Addictions, Personality, and Emotion Research, University of Maryland, College Park, MD 20742, United States.
authors.forename: Anne N
authors.initials: AN
authors.lastname: Banducci
authors.affiliation: Oklahoma State University, 118 North Murray Hall, Stillwater, OK 74075, United States.
authors.forename: DeMond M
authors.initials: DM
authors.lastname: Grant
authors.affiliation: Center for Addictions, Personality, and Emotion Research, University of Maryland, College Park, MD 20742, United States.
authors.forename: Melanie
authors.initials: M
authors.lastname: Morse
authors.affiliation: Center for Addictions, Personality, and Emotion Research, University of Maryland, College Park, MD 20742, United States.
authors.forename: C W
authors.initials: CW
authors.lastname: Lejuez
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000437:Alcoholism / Q000453:epidemiology / Q000523:psychology*; D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology*; D003866:Depressive Disorder / Q000453:epidemiology / Q000523:psychology*; D004219:District of Columbia / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057566:Self Report
keywords: Alcohol dependence; Anxiety; Anxiety sensitivity; Depression; Mediation