title: Immunosurveillance of senescent cancer cells by natural killer cells.
abstract: We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program.
authors.affiliation: Department of Molecular and Cell Biology; University of California at Berkeley; Berkeley, CA USA ; Cancer Research Laboratory; University of California at Berkeley; Berkeley, CA USA.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Iannello
authors.affiliation: Department of Molecular and Cell Biology; University of California at Berkeley; Berkeley, CA USA ; Cancer Research Laboratory; University of California at Berkeley; Berkeley, CA USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Raulet
keywords: NK cell; NKG2D; chemokine; p53; senescence