title: Photo-physical behavior of some antitumor anthracycline in solvent media with different polarity.
abstract: Absorption and emission spectra of three antitumour anthracyclines, with various substituent and stereoisomer groups, were studied in different solvents. The solute's photo-physical behavior strongly depends on solvent-solute interactions and solvent's nature. Solvatochromic method was used to investigate dipole moments of these materials in ground and excited states. Spectral variations were analyzed via means of linear solvation energy relationships concept, proposed by Kamlet and Taft. The results explain the nature of specific and non-specific solvent-solute interactions and functional groups' reorientation of studied anthracyclines in different media.
authors.affiliation: Research Institute for Applied Physics and Astronomy, University of Tabriz, Tabriz, Iran. Electronic address: Zakerhamidi@tabrizu.ac.ir.
authors.forename: M S
authors.initials: MS
authors.lastname: Zakerhamidi
authors.affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Johari-Ahar
authors.affiliation: Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, BP 5375171379 Tabriz, Iran.
authors.forename: S M
authors.initials: SM
authors.lastname: Seyed Ahmadian
authors.affiliation: Research Institute for Applied Physics and Astronomy, University of Tabriz, Tabriz, Iran; Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, BP 5375171379 Tabriz, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Kian
mesh_terms: D018943:Anthracyclines / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004396:Coloring Agents; D004317:Doxorubicin / Q000737:chemistry; D015251:Epirubicin / Q000737:chemistry; D006860:Hydrogen Bonding; D015255:Idarubicin / Q000737:chemistry; D008968:Molecular Conformation; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D004396:Coloring Agents; D012997:Solvents; D015251:Epirubicin; D004317:Doxorubicin; D015255:Idarubicin
keywords: Anthracycline; Dipole moment; Intramolecular hydrogen bonding; Linear solvation energy relationship; Solvent polarity scale; Stereoisomer