title: The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers.
abstract: The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 2 7.5 kg/m(2), had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab(®) device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens(®) algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for "24-hour", "awake", and "asleep" periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.
authors.affiliation: Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
authors.forename: Tatyana Y
authors.initials: TY
authors.lastname: Kuznetsova
authors.affiliation: Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
authors.forename: Viktoria A
authors.initials: VA
authors.lastname: Korneva
authors.affiliation: Diagnostics Department, The hospital within the Russian Railroad Network, Chita, Russia.
authors.forename: Evgeniya N
authors.initials: EN
authors.lastname: Bryantseva
authors.affiliation: Diagnostics Department, The hospital within the Russian Railroad Network, Chita, Russia.
authors.forename: Vitaliy S
authors.initials: VS
authors.lastname: Barkan
authors.affiliation: Department 65 Competitive System Analysis, National Research Nuclear University MEPhI, Moscow, Russia.
authors.forename: Artemy V
authors.initials: AV
authors.lastname: Orlov
authors.affiliation: Hemodynamic Laboratory Ltd, Nizhniy Novgorod, Russia.
authors.forename: Igor N
authors.initials: IN
authors.lastname: Posokhov
authors.affiliation: Cardiology Research Center, Moscow, Russia.
authors.forename: Anatoly N
authors.initials: AN
authors.lastname: Rogoza
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory / Q000592:standards; D002940:Circadian Rhythm; D003971:Diastole; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis / Q000592:standards; D012016:Reference Values; D012426:Russia; D012815:Signal Processing, Computer-Assisted; D013599:Systole; D013997:Time Factors; D059289:Vascular Stiffness
keywords: ambulatory; arterial stiffness; augmentation index; central blood pressure; monitoring; reference values