title: Hyperhomocysteinemia, lipid and lipoprotein disturbances in patients with primary hypertension.
abstract: OBJECTIVE
  The main aim of the study was to answer two questions: what are the concentrations of total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apo A-I (apolipoprotein A-I), apo B (apolipoprotein B) and Lp(a) (lipoprotein(a)) in serum of patients with primary hypertension and with hyperhomocysteinemia? Is there any correlation between the concentration of homocysteine in blood serum and investigated lipid and lipoprotein parameters in patients with primary hypertension?
  
  
  METHODS
  We investigated 42 patients with primary hypertension, aged 22-57. The control group consisted of 20 healthy volunteers. The concentration of homocysteine in serum was evaluated using immunochemical method (FPIA - Fluorescence Polarization Immunoassay). The concentration of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides in blood serum were estimated using enzymatic method. Apo A-I, apo B and lipoprotein(a) were assessed using nephelometric method.
  
  
  RESULTS
  The analysis of the results revealed statistically significant lower concentrations of HDL-cholesterol and apo A-I in blood serum of patients with primary hypertension and hyperhomocysteinemia than in the population with hypertension and normohomocysteinemia. Negative correlation between homocysteine and HDL-cholesterol as well as apo A-I has been revealed.
  
  
  CONCLUSIONS
  Quantitative analysis of the concentration of lipids and lipoproteins in blood serum in patients with primary hypertension and hyperhomocysteinemia may suggest that this type of human population might be more susceptible to atherosclerosis than those with primary hypertension and normal values of homocysteine.
authors.affiliation: Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: aleksandra.baszczuk@skpp.edu.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Baszczuk
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Musialik
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kopczyński
authors.affiliation: Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Thielemann
authors.affiliation: Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Kopczyński
authors.affiliation: Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Lena
authors.initials: L
authors.lastname: Kęsy
authors.affiliation: Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Dopierała
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D006973:Hypertension / Q000150:complications*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
keywords: Apolipoprotein; Cholesterol; Hyperhomocysteinemia; Hypertension; Triglycerides