title: Fecal transplant for recurrent Clostridium difficile infection in children with and without inflammatory bowel disease.
abstract: Ten children at our institution received single-infusion fecal microbiome transplant (FMT) using healthy, related screened donor stool to treat recurrent Clostridium difficile infection (RCDI) via nasogastric tube (2 patients) or colonoscopic delivery. Nine of the 10 (90%) children had resolution of their symptoms after a single-infusion FMT with follow-up of 1 month to 4 years. No concerning related adverse events were recognized during short- or long-term follow-up. Three of these children had concomitant inflammatory bowel disease and 2 of these 3 (66%) patients cleared RCDI with no clinical change in their underlying inflammatory bowel disease clinical activity as assessed by Physician's Global Assessment. All of the patients who had clinical improvement of gastrointestinal symptoms of RCDI while treated with antibiotics had lasting return of baseline health after FMT.
authors.affiliation: *Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children †Division of Pediatric Infectious Diseases, Children's Hospital Boston ‡Division of Infectious Disease, Massachusetts General Hospital, Boston, MA.
authors.forename: George H
authors.initials: GH
authors.lastname: Russell
authors.forename: Jess L
authors.initials: JL
authors.lastname: Kaplan
authors.forename: Ilan
authors.initials: I
authors.lastname: Youngster
authors.forename: Mariah
authors.initials: M
authors.lastname: Baril-Dore
authors.forename: Lili
authors.initials: L
authors.lastname: Schindelar
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hohmann
authors.forename: Harland S
authors.initials: HS
authors.lastname: Winter
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000150:complications / Q000628:therapy*; D003113:Colonoscopy; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D007441:Intubation, Gastrointestinal; D008297:Male; D064307:Microbiota / Q000187:drug effects / Q000502:physiology*; D012008:Recurrence; D014180:Transplantation / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents