title: [A new technology for evaluating pharmacodynamics of antiaggregants].
abstract: The effect of antiaggregants on the system of regulation of the aggregative state of the whole blood in healthy volunteers has been studied using the global test of low-frequency piezothrombelastography. It is established that specific effects of antiaggregants are manifested in all stages of fibrinogenesis (initiation/amplification and propagation). According to the results of the global test at initial stages of hemocoagulation (initiation/amplification), a pronounced specific antiaggregative effect of COX-1 blockers and ADP receptors is accompanied by the intensification of thrombin activity and the formation of chronometric hypercoagulation. The blocker of phosphodiesterase, while losing a specific antiaggregative effect, has a lower influence on the change of thrombin activity, thus ensuring hronometric and structural hypocoagulation at the subsequent stages of fibrinogenesis. The proposed method can be used for real-time monitoring of the results of pharmacotherapy and drug effects at various stages of fibrinogenesis in the program of personalized antiaggregant therapy.
authors.forename: I I
authors.initials: II
authors.lastname: Tiutrin
authors.forename: V F
authors.initials: VF
authors.lastname: Klimenkova
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
mesh_terms: D000328:Adult; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D000077144:Clopidogrel; D051545:Cyclooxygenase 1 / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D064368:Healthy Volunteers; D006801:Humans; D007700:Kinetics; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D057285:Precision Medicine; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D013916:Thrombelastography / Q000379:methods*; D013917:Thrombin / Q000819:agonists / Q000378:metabolism; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D018048:Receptors, Purinergic P2; D005340:Fibrinogen; D000077144:Clopidogrel; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D013917:Thrombin; D013988:Ticlopidine; D001241:Aspirin; D010431:Pentoxifylline