title: Triple-negative breast cancer: bridging the gap from cancer genomics to predictive biomarkers.
abstract: Triple-negative breast cancer (TNBC) represents a challenge clinically due to a lack of response to hormonal and HER2-targeted agents coupled with an aggressive disease course. As the biology of this breast cancer subtype is better understood, it is clear that TNBC is a heterogeneous disease and one targeted therapy is unlikely to be active in all patients. Biomarkers predictive of response to treatment are thus of great importance in TNBC. This review outlines studies evaluating biomarkers predictive of response to neoadjuvant chemotherapy and to targeted therapies in the advanced setting. The development of validated biomarkers in conjunction with novel targeted therapies represents an opportunity to improve patient outcomes in TNBC.
authors.affiliation: Department of Medical Oncology, University of Colorado Cancer Center, Aurora, CO, USA.
authors.forename: S Lindsey
authors.initials: SL
authors.lastname: Davis
authors.affiliation: Department of Medical Oncology, University of Colorado Cancer Center, Aurora, CO, USA.
authors.forename: S Gail
authors.initials: SG
authors.lastname: Eckhardt
authors.affiliation: Department of Medical Oncology, University of Colorado Cancer Center, Aurora, CO, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Tentler
authors.affiliation: Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Mailstop 8117, 12801 East 17th Avenue, Aurora, CO 80045, USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Diamond
keywords: biomarkers; targeted therapy; triple-negative breast cancer