title: The first one-pot synthesis of L-7-iodotryptophan from 7-iodoindole and serine, and an improved synthesis of other L-7-halotryptophans.
abstract: A simple and scalable one-pot biotransformation enables direct access to L-halotryptophans, including L-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required.
authors.affiliation: School of Chemistry and BSRC, University of St. Andrews , St. Andrews, KY16 9ST, U.K.
authors.forename: Duncan R M
authors.initials: DR
authors.lastname: Smith
authors.forename: Tom
authors.initials: T
authors.lastname: Willemse
authors.forename: Danai S
authors.initials: DS
authors.lastname: Gkotsi
authors.forename: Wim
authors.initials: W
authors.lastname: Schepens
authors.forename: Bert U W
authors.initials: BU
authors.lastname: Maes
authors.forename: Steven
authors.initials: S
authors.lastname: Ballet
authors.forename: Rebecca J M
authors.initials: RJ
authors.lastname: Goss
mesh_terms: D001711:Biotransformation; D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D012694:Serine / Q000737:chemistry*; D013237:Stereoisomerism; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D014367:Tryptophan Synthase / Q000378:metabolism
chemical_list: D006847:Hydrocarbons, Iodinated; D007211:Indoles; D012694:Serine; D014364:Tryptophan; D014367:Tryptophan Synthase