title: [Combination of narrow band imaging (NBI) and autofluorescence bronchoscopy (AFB) in the assessment of central lung cancer].
abstract: OBJECTIVE
  To assess the diagnostic value of narrow-band imaging(NBI) in the diagnosis of central lung cancer.
  
  
  METHODS
  Patients (n = 153) suspected of having lung cancer underwent white light bronchoscopy(WLB), NBI and autofluorescence bronchoscopy(AFB) in turn. At least 3 biopsies in each case were taken from sites visualized as lesions. The sensitivity and specificity of NBI, AFB and combination of NBI and AFB were compared.
  
  
  RESULTS
  There were 106 male (69.3%) and 47 female patients (30.7%). By NBI, 91 and 62 cases were positive and negative respectively. The sensitivity and specificity of NBI were 63.5% (87/137) and 75.0% (12/16) respectively. By AFB, 140 and 13 cases were positive and negative respectively. The sensitivity and specificity of AFB were 94.2% (129/137) and 87.5% (5/16) respectively. By NBI combined with AFB, 133 and 20 cases were positive and negative respectively, the sensitivity and specificity being 95.6% (131/137) and 87.5% (14/16) respectively. The difference of specificity between NBI plus AFB and AFB alone was significant (P < 0.01), but the difference of sensitivity between NBI plus AFB and AFB alone(P > 0.05) was not. The difference of specificity between NBI plus AFB and NBI alone was significant (P < 0.01), but the P value of specificity between NBI plus AFB and NBI was 0.03.
  
  
  CONCLUSIONS
  Combination of NBI and AFB could increase the specificity of lung cancer diagnosis compared to AFB alone.
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Zhongbo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Shifang
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Lyu
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Bijiong
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Niu
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.
authors.forename: Qunli
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China. Email: leonczb@sina.com.
authors.forename: Zaichun
authors.initials: Z
authors.lastname: Deng
mesh_terms: D000368:Aged; D001706:Biopsy; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D062048:Narrow Band Imaging; D061848:Optical Imaging; D012680:Sensitivity and Specificity