title: Homologous HOmologous Black-Bright-blood and flexible Interleaved imaging sequence (HOBBI) for dynamic contrast-enhanced MRI of the vessel wall.
abstract: OBJECTIVE
  To present a HOmologous Black-Bright-blood and flexible Interleaved imaging (HOBBI) sequence for dynamic contrast-enhanced magnetic resonance imaging (MRI) of the vessel wall.
  
  
  METHODS
  A HOBBI sequence is proposed to acquire high-spatial-resolution black-blood and high-temporal-resolution bright-blood dynamic contrast-enhanced images in an interleaved fashion. Black-blood imaging allows for thin vessel wall evaluation, whereas bright-blood imaging obtains the arterial input function accurately. A simulation was performed to assess the accuracy of the pharmacokinetic parameters [transfer constant (K(trans) ) and fractional plasma volume (vp )] generated from HOBBI. In vivo evaluation was also used to validate HOBBI in an animal model of aortic atherosclerosis.
  
  
  RESULTS
  In the simulation test, the estimated K(trans) and vp measured by HOBBI were more accurate than those from black-blood dynamic contrast-enhanced-MRI. In the animal model testing, K(trans) and vp also demonstrated good interscan reproducibility (K(trans) : ICC = 0.77, vp : ICC = 0.72, respectively). Additionally, K(trans) showed a significant increase from 1 month (0.026 ± 0.013 min(-1) ) to 2 months (0.069 ± 0.018 min(-1) ) in animal model plaque progression after balloon injury.
  
  
  CONCLUSIONS
  The proposed HOBBI sequence was demonstrated to be feasible and accurate in estimating the pharmacokinetic parameters of the atherosclerotic vessel wall, and has potential to become an early screening tool for atherosclerosis disease.
authors.affiliation: Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wu
authors.forename: Jinnan
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Deng
authors.forename: Anqi
authors.initials: A
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Wei
authors.forename: Le
authors.initials: L
authors.lastname: He
authors.forename: Xihai
authors.initials: X
authors.lastname: Zhao
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Zechen
authors.initials: Z
authors.lastname: Zhou
authors.forename: Wenchuan
authors.initials: W
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiao
authors.forename: Chun
authors.initials: C
authors.lastname: Yuan
authors.forename: Huijun
authors.initials: H
authors.lastname: Chen
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology*; D050197:Atherosclerosis / Q000473:pathology*; D003287:Contrast Media; D019786:Gadolinium DTPA; D007083:Iliac Artery / Q000473:pathology; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011817:Rabbits
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
keywords: atherosclerosis; dynamic contrast-enhanced-magnetic resonance imaging; sequence