title: Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine.
abstract: A significant portion of the world's population is infected with herpes simplex virus type 1 and/or type 2 (HSV-1 and/or HSV-2), that cause a wide range of diseases including genital herpes, oro-facial herpes, and the potentially blinding ocular herpes. While the global prevalence and distribution of HSV-1 and HSV-2 infections cannot be exactly established, the general trends indicate that: (i) HSV-1 infections are much more prevalent globally than HSV-2; (ii) over a half billion people worldwide are infected with HSV-2; (iii) the sub-Saharan African populations account for a disproportionate burden of genital herpes infections and diseases; (iv) the dramatic differences in the prevalence of herpes infections between regions of the world appear to be associated with differences in the frequencies of human leukocyte antigen (HLA) alleles. The present report: (i) analyzes the prevalence of HSV-1 and HSV-2 infections across various regions of the world; (ii) analyzes potential associations of common HLA-A, HLA-B and HLA-C alleles with the prevalence of HSV-1 and HSV-2 infections in the Caucasoid, Oriental, Hispanic and Black major populations; and (iii) discusses how our recently developed HLA-A, HLA-B, and HLA-C transgenic/H-2 class I null mice will help validate HLA/herpes prevalence associations. Overall, high prevalence of herpes infection and disease appears to be associated with high frequency of HLA-A(∗)24, HLA-B(∗)27, HLA-B(∗)53 and HLA-B(∗)58 alleles. In contrast, low prevalence of herpes infection and disease appears to be associated with high frequency of HLA-B(∗)44 allele. The finding will aid in developing a T-cell epitope-based universal herpes vaccine and immunotherapy.
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Samandary
authors.affiliation: UNITE INSERM 1016, Institut Cochin, Hôpital Saint-Vincent-de-Paul, 82, Avenue Denfert-Rochereau, 75674 Paris Cedex 14, France.
authors.forename: Hédia
authors.initials: H
authors.lastname: Kridane-Miledi
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
authors.forename: Jacqueline S
authors.initials: JS
authors.lastname: Sandoval
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
authors.forename: Zareen
authors.initials: Z
authors.lastname: Choudhury
authors.affiliation: Plate-Forme Technologique, Centre d'Ingénierie Génétique Murine, Département de Biologie du Développement, Institut Pasteur, 75015 Paris, France.
authors.forename: Francina
authors.initials: F
authors.lastname: Langa-Vives
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
authors.forename: Doran
authors.initials: D
authors.lastname: Spencer
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
authors.forename: Aziz A
authors.initials: AA
authors.lastname: Chentoufi
authors.affiliation: UNITE INSERM 1016, Institut Cochin, Hôpital Saint-Vincent-de-Paul, 82, Avenue Denfert-Rochereau, 75674 Paris Cedex 14, France.
authors.forename: François A
authors.initials: FA
authors.lastname: Lemonnier
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA 92697, USA; Institute for Immunology, University of California Irvine, Irvine, CA 92697, USA. Electronic address: Lbenmoha@uci.edu.
authors.forename: Lbachir
authors.initials: L
authors.lastname: BenMohamed
mesh_terms: D000349:Africa / Q000453:epidemiology; D000483:Alleles; D000569:Americas / Q000453:epidemiology; D000818:Animals; D001208:Asia / Q000453:epidemiology; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D005060:Europe / Q000453:epidemiology; D015870:Gene Expression; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006558:Herpes Genitalis / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D006560:Herpes Labialis / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D022301:Herpes Simplex Virus Vaccines / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D015995:Prevalence; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology
chemical_list: D018984:Epitopes, T-Lymphocyte; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D022301:Herpes Simplex Virus Vaccines
keywords: Alleles; CD8+ T-Cell; Epitope; Frequency; HLA-A; HLA-B; HLA-C; Herpes Simplex Virus; Prevalence; Vaccine