title: Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study.
abstract: Functional exercise after total knee arthroplasty (TKA) is necessary. However, it may be a difficult and painful process for the patient. Desirable methods of relieving the patient's pain are worth exploring. Oral supplement of adenosine triphosphate (ATP) is a potential option. In the present study, we decide to investigate whether short-term administration of ATP benefits patients undergoing TKA. A total of 244 subjects were randomized to receive 120mg ATP or placebo each day for 4weeks. Significant differences in quadriceps strength, pain scores at postoperative days 7, 14, 21, and 28 and total opioid consumption were detected. It follows that oral supplement of ATP could benefit patients recovering from TKA.
authors.affiliation: Department of Orthopedics, Chinese PLA General Hospital & Chinese PLA Postgraduate Medical School, Beijing, China.
authors.forename: Gong
authors.initials: G
authors.lastname: Long
authors.affiliation: Department of Orthopedics, Chinese PLA General Hospital & Chinese PLA Postgraduate Medical School, Beijing, China.
authors.forename: Guo Qiang
authors.initials: GQ
authors.lastname: Zhang
mesh_terms: D000255:Adenosine Triphosphate / Q000008:administration & dosage*; D000284:Administration, Oral; D018771:Arthralgia / Q000188:drug therapy; D019645:Arthroplasty, Replacement, Knee; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects*; D010149:Postoperative Pain / Q000188:drug therapy*; D058573:Performance-Enhancing Substances / Q000008:administration & dosage*; D052097:Quadriceps Muscle / Q000187:drug effects; D020127:Recovery of Function
chemical_list: D058573:Performance-Enhancing Substances; D000255:Adenosine Triphosphate
keywords: adenosine triphosphate (ATP); pain; quadriceps strength; recovery; total knee arthroplasty (TKA)