title: Acetazolamide and Thyroid-Associated Ophthalmopathy; a Preliminary Tested Hypothesis in a TertiaryReferral Center.
abstract: This study evaluated the effect of acetazolamide on thyroid-associated ophthalmopathy (TAO). Patients with a VISA classification index equal to or more than four were enrolled in the study and were randomly assigned into two groups. In both groups, treatment was initiated using prednisolone. Patients in the case group received acetazolamide tablets 250 mg daily in addition to prednisolone. Three months later, the VISA inflammatory score of patients in both groups were determined. Subsequent to intervention with acetazolamide, the VISA inflammatory score of patients in the case group were reduced as follows; orbital pain (57.1% versus 41.7%, P=0.736), eyelid edema (42.8% versus 27.1%, P=0.67), chemosis (53.3% versus 33%, P=0.31), injection of the eyelids (60% versus 41.6%, P=0.342), and conjunctival injection (50% versus 46.13%, P=0.73). However, these reductions were not statistically significant when compared with those observed in the control group (P=0.246). In conclusion, the effect of acetazolamide on all the parameters of the VISA inflammatory score was examined independently. All patients in the case group revealed a reduction in VISA inflammatory score following intervention. However, these reductions were not statistically significant. Further studies with large sample sizes are required.
authors.affiliation: Department of Ophthalmology, Ophthalmology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Khataminia
authors.affiliation: Department of Ophthalmology, Ophthalmology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Farshad
authors.initials: F
authors.lastname: Ostadian
authors.affiliation: Department of Ophthalmology, Ophthalmology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Noroozzadeh
authors.affiliation: Department of Health, Diabetes Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Latifi
authors.affiliation: Department of Ophthalmology, Ophthalmology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Khataminia
keywords: Acetazolamide; Conjunctival injection; Eyelid edema; Injection of the eyelids; Orbital pain; Thyroid-associated ophthalmopathy (TAO); VISA score; chemosis