title: p40 is the best marker for diagnosing pulmonary squamous cell carcinoma: comparison with p63, cytokeratin 5/6, desmocollin-3, and sox2.
abstract: Histologic distinction among non-small cell lung carcinomas, particularly between squamous cell carcinoma (SQC) and adenocarcinoma (ADC), has become more important. Recently, a p40 antibody was suggested to be a highly specific marker for SQC. We evaluated p40 expression and compared it with the expression of other SQC markers in 580 primary lung carcinomas, including 158 SQCs, 156 ADCs, 50 carcinoid tomors, 107 large cell neuroendocrine carcinomas, 68 small cell lung carcinomas, and 41 malignant mesotheliomas. Detailed histologic distributions of p40-positive cases were as follows: 153 (96.8%) of 158 SQCs, 7 (4.6%) of 152 ADCs, 0 (0%) of 50 carcinoid tomors, 4 (3.6%) of 107 large cell neuroendocrine carcinomas, 1 (1.5%) of 68 small cell lung carcinomas, and 1 (2.4%) of 41 mesotheliomas. p40 staining yields high sensitivity as well as high specificity for distinguishing SQC from ADC, neuroendocrine carcinomas, and malignant mesothelioma.
authors.affiliation: *Department of Pathology and Clinical Laboratories, National Cancer Center Hospital †Division of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tatsumori
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuta
authors.forename: Kyohei
authors.initials: K
authors.lastname: Masai
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Kinno
authors.forename: Tomoko
authors.initials: T
authors.lastname: Taniyama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000175:diagnosis*; D018287:Carcinoma, Large Cell / Q000175:diagnosis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D002454:Cell Differentiation; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D051187:Desmocollins / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D053555:Keratin-5 / Q000378:metabolism; D053553:Keratin-6 / Q000378:metabolism; D008175:Lung Neoplasms / Q000175:diagnosis*; D008565:Membrane Proteins / Q000378:metabolism; D008654:Mesothelioma / Q000175:diagnosis*; D000086002:Mesothelioma, Malignant; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D012680:Sensitivity and Specificity; D000095043:Cyclin-Dependent Kinase-Activating Kinase
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; C490356:DSC3 protein, human; D051187:Desmocollins; D053555:Keratin-5; D053553:Keratin-6; D008565:Membrane Proteins; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D018844:Cyclin-Dependent Kinases; D000095043:Cyclin-Dependent Kinase-Activating Kinase