title: Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages.
abstract: Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.
authors.affiliation: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
authors.forename: Antimo
authors.initials: A
authors.lastname: Cutone
authors.forename: Alessandra
authors.initials: A
authors.lastname: Frioni
authors.forename: Francesca
authors.initials: F
authors.lastname: Berlutti
authors.forename: Piera
authors.initials: P
authors.lastname: Valenti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Musci
authors.forename: Maria Carmela
authors.initials: MC
authors.lastname: Bonaccorsi di Patti
mesh_terms: D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D002417:Cattle; D002454:Cell Differentiation; D002460:Cell Line; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis; D007501:Iron / Q000378:metabolism; D007781:Lactoferrin / Q000378:metabolism* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D000098742:Ferroportin
chemical_list: D027682:Cation Transport Proteins; C508600:IL6 protein, human; D007155:Immunologic Factors; D015850:Interleukin-6; D008070:Lipopolysaccharides; D000098742:Ferroportin; D007501:Iron; D007781:Lactoferrin