title: Obesity corrupts myelopoiesis.
abstract: Ongoing monocyte infiltration and subsequent macrophage seeding of adipose tissue is thought to be a key feature of obesity pathophysiology. Nagareddy et al. (2014) show that adipose cells locally activate IL-1β in macrophages in part through the alarmin S100A8/A9, which stimulates bone marrow myelopoiesis to perpetuate nonresolving inflammation.
authors.affiliation: Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: peter.murray@stjude.org.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Murray
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D038042:Myelopoiesis / Q000502:physiology*; D009765:Obesity / Q000378:metabolism*