title: Tissue oxygen partial pressure in the tibialis anterior muscle in patients with claudication before, during and after a two-stage treadmill stress test.
abstract: BACKGROUND
  The role of the microcirculation in the pathophysiology and symptoms of peripheral arterial obliterative disease (PAOD) has been progressively emphasized during the past decades. Under resting conditions, already, the tissue oxygen partial pressure in the m. tibialis anterior (pO2im) is reduced to about 50% compared to healthy subjects.
  
  
  METHODS
  In the framework of this study the pO2im of patients with PAOD stage II according to Fontaine (n=16) in the m. tibialis anterior was measured under resting conditions and during walking on a treadmill in comparison to healthy subjects (n=10).
  
  
  RESULTS
  Under resting conditions the pO2im only marginally differed between PAOD patients and healthy subjects. But during exercise the pO2im dropped significantly more severely in PAOD patients and a return to baseline values could only be reached when the treadmill was stopped and the patients stood still. The pO2im minima correlated clearly with the clinical symptom of calf pain.
  
  
  CONCLUSIONS
  The data revealed that the pO2im values were lower in PAOD patients and dropped significantly faster during walking compared to the pO2im values in healthy subjects. The pO2im decrease correlated with the calf pain occurring when the pO2im values approached or fell below 10 mmHg.
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Jung
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Krüger
authors.affiliation: Department for Clinical Hemostasiology and Transfusion Medicine, University Saarland, Homburg/Saar, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Pindur
authors.affiliation: Akademische Lehrpraxisklinik der Technischen Universität Dresden, Dresden, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Sternitzky
authors.affiliation: Department of Biomaterials, University of Ulm, Ulm, Germany.
authors.forename: R P
authors.initials: RP
authors.lastname: Franke
authors.affiliation: Department of Cardiology, University Medical Center Mainz, Mainz, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Gori
mesh_terms: D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D001161:Arteriosclerosis / Q000175:diagnosis*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D010313:Partial Pressure; D058729:Peripheral Arterial Disease / Q000175:diagnosis*
chemical_list: D010100:Oxygen
keywords: Tissue oxygen partial pressure; peripheral arterial occlusive disease; treadmill test