title: Introduction of misoprostol for the treatment of incomplete abortion beyond 12 weeks of pregnancy in Benin.
abstract: Improving the care of women who have undergone a spontaneous or induced abortion is an important step in reducing abortion-related morbidity and mortality. Both the International Federation of Gynecology and Obstetrics (FIGO) and the World Health Organization recommend the use of manual vacuum aspiration (MVA) and misoprostol rather than sharp curettage to treat incomplete abortion. MVA was introduced into the public healthcare service in Benin in 2006 and since 2008 misoprostol has been available in 3 large maternity hospitals. The present study opted to use an oral dose of 800 μg and not to limit to pregnancies of up to 12 weeks, but to include women with second trimester abortions. After 5 years, results show that around three-quarters of the women treated with misoprostol at 13-18 weeks of pregnancy required MVA to complete uterine evacuation and approximately one-quarter had severe bleeding, confirming that the indication of misoprostol for incomplete abortion should be limited to pregnancies of up to 12 weeks.
authors.affiliation: Hubert Koutoukou Maga National Teaching Hospital, Cotonou, Benin.
authors.forename: Sosthène
authors.initials: S
authors.lastname: Adisso
authors.affiliation: Lagoon Mother and Child Hospital, Cotonou, Benin. Electronic address: bhounkpatin@yahoo.fr.
authors.forename: Benjamin I B
authors.initials: BI
authors.lastname: Hounkpatin
authors.affiliation: Lagoon Mother and Child Hospital, Cotonou, Benin.
authors.forename: Gounnou D
authors.initials: GD
authors.lastname: Komongui
authors.affiliation: Hubert Koutoukou Maga National Teaching Hospital, Cotonou, Benin.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sambieni
authors.affiliation: Lagoon Mother and Child Hospital, Cotonou, Benin.
authors.forename: René X
authors.initials: RX
authors.lastname: Perrin
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000027:Abortion, Incomplete / Q000628:therapy*; D001541:Benin; D005260:Female; D006771:Hospitals, Maternity / Q000706:statistics & numerical data; D006801:Humans; D007390:International Agencies / Q000458:organization & administration; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011446:Prospective Studies; D014619:Vacuum Curettage / Q000379:methods*; D014944:World Health Organization
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol
keywords: Benin; Complications; FIGO initiative; Gestational age; Incomplete abortion; Misoprostol; Prevention; Unsafe abortion