title: New daily persistent headache: an update.
abstract: New daily persistent headache is a primary headache disorder marked by a unique temporal profile which is daily from onset. For many sufferers this is their first ever headache. Very little is known about the pathogenesis of this condition. It might be a disorder of abnormal glial activation with persistent central nervous system inflammation and it may be a syndrome that occurs in individuals who have a history of cervical hypermobility. At present there is no known specific treatment and many patients go for years to decades without any improvement in their condition despite aggressive therapy. This article will present an up-to-date overview of new daily persistent headache on the topics of clinical presentation, treatment, diagnostic criteria, and presumed pathogenesis. It will also provide some of the authors own treatment suggestions based on recognized triggering events and some suggestions for future clinical trials.
authors.affiliation: Department of Neurology, Geisinger Health System- Geisinger Wyoming Valley, MC 37-31, 1000 E. Mountain Drive, Wilkes-Barre, PA, 18711, USA, tdrozmigraine@yahoo.com.
authors.forename: Todd D
authors.initials: TD
authors.lastname: Rozen
mesh_terms: D061605:Administration, Intravenous; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D017668:Age of Onset; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use*; D020773:Headache Disorders / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008801:Mexiletine / Q000627:therapeutic use*; D012720:Severity of Illness Index; D017678:Sex Distribution; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
chemical_list: D000305:Adrenal Cortex Hormones; D000889:Anti-Arrhythmia Agents; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D008801:Mexiletine; D004318:Doxycycline