title: Genetic study of Hormad1 and Hormad2 with non-obstructive azoospermia patients in the male Chinese population.
abstract: OBJECTIVE
  To evaluate the association of the Hormad1 and Hormad2 single nucleotide polymorphisms (SNPs) variants with non-obstructive azoospermia (NOA) in the Chinese population.
  
  
  METHODS
  In the present study, we assessed 10 single nucleotide polymorphisms (SNPs) of Hormad1 and Hormad2 using Sequenom iplex technology in 361 NOA cases and 368 normal controls from Chinese population.
  
  
  RESULTS
  We observed no statistical differences in the distribution of allele frequencies. Further genetic model analysis and haplotype analysis also showed no significant difference between the two groups. However, we found that genotype distribution of rs718772 of Hormad2 was significantly different between the larger testis group (average testis volume ≥10 ml) and the small testis group (average testis volume <10 ml) in the NOA patients (P = 0.035).
  
  
  CONCLUSIONS
  In conclusion, Hormad1 and Hormad2 might not be the susceptible genes for the non-obstructive azoospermia in our study population. However, rs718772 of Hormad2 variant might be associated with testis development in NOA patients.
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Song
authors.forename: Xiaojin
authors.initials: X
authors.lastname: He
authors.forename: Weidong
authors.initials: W
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Ruan
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zhou
authors.forename: Xian-bo
authors.initials: XB
authors.lastname: Zuo
authors.forename: Huan
authors.initials: H
authors.lastname: Wu
authors.forename: Xing
authors.initials: X
authors.lastname: Zha
authors.forename: Shuhua
authors.initials: S
authors.lastname: Liu
authors.forename: Xu-shi
authors.initials: XS
authors.lastname: Xie
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.forename: Zhaolian
authors.initials: Z
authors.lastname: Wei
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Cao
mesh_terms: D000328:Adult; D044466:Asian People; D053713:Azoospermia / Q000235:genetics* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000033:anatomy & histology
chemical_list: D018797:Cell Cycle Proteins; C576915:HORMAD1 protein, human