title: Expression of the glucose transporter GLUT12 in Alzheimer's disease patients.
abstract: Alzheimer's disease (AD) might be conceptualized as a metabolic disease with progressive impairment of the brain's capacity to utilize glucose. One of the last glucose transporters discovered is GLUT12. The aim of the present work was to investigate the expression of GLUT12 in frontal cortex from AD patients. Human samples from young control donors barely expressed GLUT12. The level of expression of GLUT12 was significantly higher in AD compare to aged controls. Expression of GLUT12 and Ox-42, a microglia marker, correlate in controls but not in AD. The implications of these findings in AD are discussed further.
authors.affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.
authors.forename: Jonai
authors.initials: J
authors.lastname: Pujol-Gimenez
authors.affiliation: Department of Cellular and Molecular Neuropharmacology, Division of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Martisova
authors.affiliation: Department of Cellular and Molecular Neuropharmacology, Division of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Perez-Mediavilla
authors.affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Lostao
authors.affiliation: Department of Cellular and Molecular Neuropharmacology, Division of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Ramirez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D015153:Blotting, Western; D039481:CD11b Antigen / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism*; D006801:Humans; D008297:Male; D017628:Microglia / Q000378:metabolism
chemical_list: D039481:CD11b Antigen; D051246:Glucose Transport Proteins, Facilitative; C509295:ITGAM protein, human; C449579:SLC2A12 protein, human
keywords: Frontal cortex; glucose transport; microglia; western blot