title: Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents.
abstract: A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular activity, particularly CGI17341 (5a). In the present study (5a) and (5d) and (7) were found to be more potent antileishmanials in vitro than the standard and less toxic in relation to a reference compound. (7) Was earlier formulated to have the phenyl group located on C-2(5b).
authors.affiliation: Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058, India.
authors.lastname: Shashiprabha
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore-574 199, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Nayak
authors.affiliation: Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058, India.
authors.forename: K Sundarraja
authors.initials: KS
authors.lastname: Rao
authors.affiliation: Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058, India.
authors.forename: K
authors.initials: K
authors.lastname: Nagarajan
authors.affiliation: Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058, India.
authors.forename: K
authors.initials: K
authors.lastname: Shridhara
authors.affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Torreele
authors.affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
authors.forename: B B
authors.initials: BB
authors.lastname: Trunz
keywords: Nitroimidazoles; antileishmanial activity; nitroimidazooxazoles; satranidazole