title: [Gynecological malignant tumor related multiple primary malignant neoplasms: clinical analysis of 30 cases].
abstract: OBJECTIVE
  To investigate the clinical features of gynecological malignant tumor related multiple primary malignant neoplasms (MPMN).
  
  
  METHODS
  Apply retrospective and comprehensive analysis to the clinical data of 30 patients with gynecological malignant tumor related MPMN.
  
  
  RESULTS
  Synchronous MPMN were found in 9 patients. Their average age was 50.2 years old and their median age was 49 years old. The neoplasms were located at ovary, uterus, cervix, breast and intestine. Metachronous MPMN were found in 21 patients. Their average age was 57.7 and their median age was 57 years old. The median interval between the first and the second primary malignant neoplasm was 4.0 years. The neoplasms were located at breast, ovary, uterus, gastrointestinal tract, uterine cervix, lung etc. In 30 cases, 26 of them were treated by surgical operation and further adjunctive treatment of chemotherapy and (or) radiotherapy was conducted as per the neoplasm staging and its pathological results. The rest 4 patients (first primary malignant neoplasms were excised from 3 of them and another one was not treated by surgical operation) received adjunctive treatment of chemotherapy and (or) radiotherapy. Followed ups, which varied from 6 to 60 months, were made to 29 patients and 20 out of the 29 were alive.5-year survival rate of patients with gynecological malignant tumor related MPMN was 47.8%, 2-year survival rate was 73.9%, and 1-year survival rate was 88.6%.
  
  
  CONCLUSIONS
  Pay more attention to the patients with gynecological malignant tumor related MPMN, examine the high-risk patients with malignant tumor comprehensively, identify whether it is recurrence, metastasis or new growth of malignant neoplasm, and further ensure early diagnosis and proper treatment, avoiding misdiagnosis and missed diagnosis.
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China.
authors.forename: Shulin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China.
authors.forename: Yicong
authors.initials: Y
authors.lastname: Wan
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China.
authors.forename: Shilong
authors.initials: S
authors.lastname: Fu
authors.affiliation: Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036, China. Email: chengwenjundoc@163.com.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Cheng
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors