title: [Farmacological effect of retabolil on aldosterone level and arterial pressure in rats under the action of vibrations].
abstract: The experiments were performed on male rats, which were subjected to single and multiply repeated vibrations (low-frequency, horizontal, high-amplitude) analogous to the action of motor transport vibrations. It is established that the administration of retabolil produces a hypotensive effect and blocks the vibration-induced increase in the level of hypertensive hormone aldosterone. Under conditions of the multiply repeated action of vibrations, both effects were realized via micro-opioid receptors. In the case of a single action, these receptors were only involved in a hypotensive effect but not mediated in aldosterone suppression. Both these effects were absent in the control group of animals (not subjected to vibrations). Therefore, retabolil can be used as a hypotensive and aldosterone-blocking drug for vibration-induced hypertension in animals and, probably, in humans.
authors.forename: T A
authors.initials: TA
authors.lastname: Obut
authors.forename: M V
authors.initials: MV
authors.lastname: Ovsiukova
authors.forename: S A
authors.initials: SA
authors.lastname: Egorova
authors.forename: T A
authors.initials: TA
authors.lastname: Érdynieva
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Dement'eva
authors.forename: E T
authors.initials: ET
authors.lastname: Obut
mesh_terms: D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects*; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism; D014732:Vibration / Q000009:adverse effects
chemical_list: D045930:Anabolic Agents; D000451:Mineralocorticoid Receptor Antagonists; D017450:Receptors, Opioid, mu; D000450:Aldosterone; D009277:Nandrolone; D000077603:Nandrolone Decanoate