title: Comparison of isoflurane and propofol for maintenance of anesthesia in dogs with intracranial disease undergoing magnetic resonance imaging.
abstract: OBJECTIVE
  To compare isoflurane and propofol for maintenance of anesthesia and quality of recovery in client-owned dogs with intracranial disease undergoing magnetic resonance imaging (MRI).
  
  
  METHODS
  Prospective, randomized, clinical trial.
  
  
  METHODS
  Twenty-five client-owned dogs with intracranial pathology, 13 females and 12 males, ages 11 months to 13 years, weighing between 3.0 and 48.0 kg.
  
  
  METHODS
  Each dog was randomly assigned to receive propofol or isoflurane for maintenance of anesthesia. All dogs were not premedicated, were administered propofol intravenously to effect for induction, intubated and mechanically ventilated to maintain an end-tidal carbon dioxide tension 30-35 mmHg (4.0-4.7 kPa). Temperature and cardiac output were measured pre- and post-MRI. Scores for mentation, neurological status, ease of maintenance, and recovery were obtained pre- and post-anesthesia. Pulse oximetry, end-tidal gases, arterial blood pressure, heart rate (HR) and requirements for dopamine administration to maintain mean arterial pressure (MAP) >60 mmHg were recorded throughout anesthesia.
  
  
  RESULTS
  End-tidal isoflurane concentration was 0.73 ± 0.35% and propofol infusion rate was 292 ± 119 μg kg(-1)  minute(-1) . Cardiac index was higher, while HR was lower, with propofol than isoflurane in dogs younger than 5 years, but not in older dogs. Dogs maintained with isoflurane were 14.7 times more likely to require dopamine than propofol dogs. Mentation and maintenance scores and temperature were not different. MAP and diastolic arterial pressure were higher in the propofol group. Recovery scores were better with propofol, although times to extubation were similar. Change in neurological score from pre- to post-anesthesia was not different between treatments.
  
  
  CONCLUSIONS
  Dogs maintained with propofol during MRI had higher arterial pressures, decreased requirements for dopamine, and better recovery scores, compared to dogs maintained with isoflurane.
  
  
  CONCLUSIONS
  Propofol anesthesia offered cardiovascular and recovery advantages over isoflurane during MRI in dogs with intracranial disease in this study.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
authors.forename: Deanne
authors.initials: D
authors.lastname: Caines
authors.forename: Melissa
authors.initials: M
authors.lastname: Sinclair
authors.forename: Alexander
authors.initials: A
authors.lastname: Valverde
authors.forename: Doris
authors.initials: D
authors.lastname: Dyson
authors.forename: Luis
authors.initials: L
authors.lastname: Gaitero
authors.forename: Darren
authors.initials: D
authors.lastname: Wood
mesh_terms: D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000818:Animals; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007530:Isoflurane / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D015742:Propofol / Q000008:administration & dosage; D011446:Prospective Studies
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D015742:Propofol
keywords: anesthesia; brain; isoflurane; propofol