title: Dramatic solvent effect on the synergy between α-tocopherol and BHT antioxidants.
abstract: During the DPPH scavenging assay carried out in non polar and non protic solvents, such as toluene, BHT regenerates α-tocopherol from tocopheryl radical, whereas in polar and protic solvents, like methanol, no regeneration is observed due to a fast electron transfer reaction from the tocopheryl radical to the reactive DPPH radical. Surprisingly, in the presence of a small amount of alcohol, the synergy is exalted and BHT regenerates twice as much α-tocopherol due to a nucleophilic addition of short alcohols on the BHT oxidation product, giving a new phenolic co-antioxidant.
authors.affiliation: Université Lille1 and ENSCL, EA 4478 Chimie Moléculaire et Formulation, Cité Scientifique, Bâtiment C6, F-59655 Villeneuve d'Ascq Cedex, France.
authors.forename: Clémentine
authors.initials: C
authors.lastname: Marteau
authors.affiliation: International Flavors & Fragrances Research and Development, 61 rue de Villiers, 95253 Neuilly-sur-Seine Cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Favier
authors.affiliation: Université Lille1 and ENSCL, EA 4478 Chimie Moléculaire et Formulation, Cité Scientifique, Bâtiment C6, F-59655 Villeneuve d'Ascq Cedex, France. Electronic address: veronique.rataj@univ-lille1.fr.
authors.forename: Véronique
authors.initials: V
authors.lastname: Nardello-Rataj
authors.affiliation: Université Lille1 and ENSCL, EA 4478 Chimie Moléculaire et Formulation, Cité Scientifique, Bâtiment C6, F-59655 Villeneuve d'Ascq Cedex, France. Electronic address: jean-marie.aubry@univ-lille1.fr.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Aubry
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002084:Butylated Hydroxytoluene / Q000737:chemistry*; D004357:Drug Synergism; D016166:Free Radical Scavengers / Q000737:chemistry; D000432:Methanol; D010084:Oxidation-Reduction; D010636:Phenols; D012997:Solvents / Q000737:chemistry*; D024502:alpha-Tocopherol / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D010636:Phenols; D012997:Solvents; D002084:Butylated Hydroxytoluene; D024502:alpha-Tocopherol; D000432:Methanol
keywords: Alcohol; Antioxidants; BHT; DPPH; Solvent effect; Synergy; α-Tocopherol