title: Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study.
abstract: BACKGROUND
  The ataxia-telangiectasia mutated (ATM) gene plays an important role in the DNA double-strand breaks repair pathway. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence the risk of lung cancer. This study aimed to investigate the association between the ATM -111G>A (rs189037) polymorphism, environmental risk factors and the risk of lung adenocarcinoma in Chinese female non-smokers.
  
  
  METHODS
  A hospital-based case-control study of 487 lung cancer patients and 516 matched cancer-free controls was conducted. Information concerning demographic and environmental risk factors was obtained for each case and control by a trained interviewer. After informed consent was obtained, 10 ml venous blood was collected from each subject for biomarker testing. Single nucleotide polymorphism was determined by using TaqMan method.
  
  
  RESULTS
  This study showed that the individuals with ATM rs189037 AA genotype were at an increased risk for lung adenocarcinoma compared with those carrying the GA or GG genotype (adjusted odds ratios (OR) 1.44, 95% confidence interval (CI) 1.02-2.02, P = 0.039). The stratified analysis suggested that increased risk associated with ATM rs189037 AA genotype in individuals who never or seldom were exposed to cooking oil fumes (adjusted OR 1.89, 95%CI 1.03-3.49, P = 0.040).
  
  
  CONCLUSIONS
  ATM rs189037 might be associated with the risk of lung adenocarcinoma in Chinese non-smoking females. Furthermore, ATM rs189037 AA genotype might be a risk factor of lung adenocarcinoma among female non-smokers without cooking oil fume exposure.
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Heping District, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Heping District, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Heping District, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Heping District, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, China.
authors.forename: Yangwu
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Heping District, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Heping District, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, China.
authors.forename: Baosen
authors.initials: B
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D044466:Asian People; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics*; D016022:Case-Control Studies; D003296:Cooking; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins