title: Toll-like receptor genetic variants and colorectal cancer.
abstract: Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.
authors.affiliation: Interfaculty Institute for Cell Biology; Department of Immunology; University of Tübingen; Tübingen, Germany.
authors.forename: Alexander Nr
authors.initials: AN
authors.lastname: Weber
authors.affiliation: Division of Molecular Genetic Epidemiology; German Cancer Research Center (DKFZ); Heidelberg, Germany ; Center for Primary Health Care Research; Clinical Research Center; Lund University; Malmö, Sweden.
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
keywords: Toll-like receptors; biomarker; colorectal cancer; flagellin; single-nucleotide polymorphism