title: Cyclic mood disorder heralding adult-onset autosomal dominant leucodystrophy: a clinical masquerader.
abstract: Leucodystrophies are a heterogeneous group of progressive white matter diseases which may be inherited in dominant, recessive or X-linked fashion depending on the type. Adrenoleucodystrophy (ALD) and metachromatic leucodystrophy (MLD) are rather commoner forms of leucodystrophies whereas krabbes disease, alexander disease, cannavans disease etc. are of less common type. Adult-onset autosomal dominant leucodystrophy (ADLD) is a lately described rarer form of leucodystrophy with perhaps no case report from India. Various leucodystrophies may have different clinical presentations, ranging from subtle cognitive and psychiatric manifestations to gross motor disabilities, visual impairment and seizure. Psychiatric manifestations in the form of psychoses and frank schizophrenia are commonly described in MLD. Depression though uncommonly reported in MLD, cyclic mood disorders have been rarely described in any form of leucodystrophies. We are reporting an eye opener, a case of ADLD which masqueraded as a rapid cyclic mood disorder for initial four years, later to be followed by progressive neurological signs and symptoms. To the best of our knowledge, this is perhaps the first case report of ADLD presenting as rapid cyclic mood disorder in the world literature.
authors.affiliation: Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India. Electronic address: drrsjain@yahoo.com.
authors.forename: Rajendra S
authors.initials: RS
authors.lastname: Jain
authors.affiliation: Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India. Electronic address: vanswayam@rediffmail.com.
authors.forename: Swayam
authors.initials: S
authors.lastname: Prakash
authors.affiliation: Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India. Electronic address: padayappa4u@gmail.com.
authors.forename: B S
authors.initials: BS
authors.lastname: Raghavendra
authors.affiliation: Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India. Electronic address: kadamnagpal@gmail.com.
authors.forename: Kadam
authors.initials: K
authors.lastname: Nagpal
authors.affiliation: Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India. Electronic address: pratibha_doc2000@yahoo.co.in.
authors.forename: Rahul
authors.initials: R
authors.lastname: Handa
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D003865:Major Depressive Disorder / Q000209:etiology* / Q000473:pathology; D020279:Hereditary Central Nervous System Demyelinating Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D007194:India; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: Adrenoleucodystrophy; Adult-onset autosomal dominant leucodystrophy; Cyclic mood disorder; Metachromatic leucodystrophy; Psychoses