title: Assessing Pseudomonas virulence with nonmammalian host: Galleria mellonella.
abstract: Pseudomonas aeruginosa is an opportunistic human pathogen responsible for severe to deadly infections in patients suffering from cystic fibrosis, AIDS, undergoing immune suppressing therapies or suffering from severe burns. In the recent years there has been an increasing interest in exploring animal infection models that, to a certain extent, could mimic human infections. Here we describe the use of the larvae of the greater wax moth Galleria mellonella as a non-expensive, easy-to-use, and easy-to-obtain animal model to study P. aeruginosa infections.
authors.affiliation: Department of Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Koch
authors.forename: Pol
authors.initials: P
authors.lastname: Nadal-Jimenez
authors.forename: Robbert H
authors.initials: RH
authors.lastname: Cool
authors.forename: Wim J
authors.initials: WJ
authors.lastname: Quax
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001681:Biological Assay / Q000379:methods*; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D007328:Insulin; D008322:Mammals; D009036:Moths / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000472:pathogenicity*; D014774:Virulence / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D007328:Insulin