title: Calcium channel blockers and prostate cancer.
abstract: The relationship between calcium channel blockers and prostate cancer has been an area of increased interest to investigators. Calcium channel blockers have been shown to influence cell proliferation, differentiation, and apoptosis. Clinically, the association between calcium channel blockers and the development of prostate cancer has been controversial. However, on a basic science level, there is evidence that calcium channel blockers induce cytotoxicity in androgen receptor positive cell lines and may offer an innovative strategy for the treatment of castration-resistant prostate cancer.
authors.affiliation: Division of Urology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address: kloughlin@partners.org.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Loughlin
mesh_terms: D020746:Calcium Channels, L-Type / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: C410798:AR protein, human; C472073:CACNA1D protein, human; D020746:Calcium Channels, L-Type; D011944:Receptors, Androgen
keywords: Calcium channel blockers; Prostate cancer