title: The effect of calpain-10 gene polymorphism on the development of type 2 diabetes mellitus in a Turkish population.
abstract: BACKGROUND
  The variations in the Calpain-10 gene have been suggested to be related to susceptibility to type 2 diabetes mellitus (T2DM) in different populations. In this study, we investigated the relationship between single nucleotide polymorphism (SNP)-19, -44 and -63 in the Calpain-10 gene and the development of T2DM in a Turkish population.
  
  
  METHODS
  A total of 211 subjects were recruited: 118 patients with a diagnosis of T2DM and 93 unrelated healthy subjects.
  
  
  RESULTS
  There were no significant differences in the genotype and allele distribution of SNPs studied between the patients with T2DM and controls (p > 0.05), whereas the frequencies of 121 haplotype and 122/121 haplotype combination were found to be higher in patients with T2DM than in controls (p < 0.05). No association was observed between the variations in the Calpain-10 gene and glycaemic control and lipid parameters (p > 0.05). The SNP-19 insertion/insertion was significantly related to increased body mass index (BMI) in male diabetic patients (p < 0.05).
  
  
  CONCLUSIONS
  The present study indicates that 121 haplotype and 122/121 haplotype combination of SNP-19, -44 and -63 in the Calpain-10 gene are associated with the development of T2DM in Turkish patients.
authors.forename: Emre
authors.initials: E
authors.lastname: Arslan
authors.forename: Leyla
authors.initials: L
authors.lastname: Acik
authors.forename: Gulsah
authors.initials: G
authors.lastname: Gunaltili
authors.forename: Goksun
authors.initials: G
authors.lastname: Ayvaz
authors.affiliation: alevaltinova@yahoo.com.
authors.forename: Alev E
authors.initials: AE
authors.lastname: Altinova
authors.forename: Metin
authors.initials: M
authors.lastname: Arslan
mesh_terms: D000328:Adult; D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014421:Turkey
chemical_list: D002154:Calpain; C415197:calpain 10