title: [Frequency of allele polymorphism of immune proteasome catalytic subunits in patients with ischemic stroke].
abstract: Frequency of allelic variants of proteasome subunits genes LMP2 (Arg60 --> His) and PSMA6 were determined in patients with ischemic stroke using real-time PCR. Allelic variants of PSMA6 were disposed in the next manner: C/C - 80.2%, C/G - 19.8%, G/G--were not (in control) and C/C - 75.5%, C/G - 21.4%, G/G - 3.1% (P = 0.22) in patients with IS. It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P > 0.05). The data show that LMP2 and PSMA6 gene polymorphism is not a risk factor of ischemic stroke in Ukrainian population.
authors.forename: O I
authors.initials: OI
authors.lastname: Savchuk
authors.forename: V S
authors.initials: VS
authors.lastname: Mel'nyk
authors.forename: S V
authors.initials: SV
authors.lastname: Goncharov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Shandiuk
authors.forename: D O
authors.initials: DO
authors.lastname: Stroĭ
authors.forename: V Ie
authors.initials: VIe
authors.lastname: Dosenko
authors.forename: L I
authors.initials: LI
authors.lastname: Sokolova
authors.forename: H H
authors.initials: HH
authors.lastname: Skybo
mesh_terms: D000368:Aged; D020520:Brain Infarction / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D003546:Cysteine Endopeptidases / Q000235:genetics*; D004247:DNA / Q000235:genetics; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D046988:Proteasome Endopeptidase Complex / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D014455:Ukraine
chemical_list: C071313:LMP-2 protein; D004247:DNA; D003546:Cysteine Endopeptidases; C465641:PSMA6 protein, human; D046988:Proteasome Endopeptidase Complex