title: IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study.
abstract: IQP-GC-101 is a patented blend of the standardized extracts of Garcinia cambogia, Camellia sinensis, unroasted Coffea arabica, and Lagerstroemia speciosa. These individual ingredients of IQP-GC-101 have each shown promise in promoting weight loss; however, the efficacy of the blend has not been established. This randomized, placebo-controlled, double-blind, parallel group study conducted over 14 weeks (including a 2-week run-in phase) aimed to investigate the efficacy and safety of IQP-GC-101 in reducing body weight and body fat mass in overweight Caucasian adults. Subjects took three IQP-GC-101 or placebo tablets, twice a day, 30 min before main meals. All subjects also adhered to a 500 kcal/day energy deficit diet with 30% of energy from fat. Ninety-one overweight and mildly obese subjects (46 in the IQP-GC-101 group, 45 in the placebo group) completed the study. After 12-week intervention, IQP-GC-101 resulted in a mean (±SD) weight loss of 2.26 ± 2.37 kg compared with 0.56 ± 2.34 kg for placebo (pU  = 0.002). There was also significantly more reduction in body fat mass, waist circumference, and hip circumference in the IQP-GC-101 group. No serious adverse events were reported. The use of IQP-GC-101 has been shown to result in body weight and body fat reduction in the current study, with good tolerability.
authors.affiliation: InQpharm Europe Ltd, Invision House, Wilbury Way, Hitchin, Hertfordshire, SG4 0TY, UK.
authors.forename: Pee-Win
authors.initials: PW
authors.lastname: Chong
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Beah
authors.forename: Barbara
authors.initials: B
authors.lastname: Grube
authors.forename: Linda
authors.initials: L
authors.lastname: Riede
mesh_terms: D050154:Adiposity; D000328:Adult; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D050177:Overweight / Q000188:drug therapy; D010936:Plant Extracts / Q000627:therapeutic use*; D055105:Waist Circumference; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; C000596343:IQP-GC-101; D010936:Plant Extracts
keywords: body fat; herbal extracts; obesity; overweight; weight management