title: Interleukin-6 and vitamin D status during high-intensity resistance training in patients with chronic kidney disease.
abstract: Background. The aim of this study was to investigate IL-6 and 25-hydroxyvitamin D (25-OH D) associations with muscle size and muscle function in dialysis patients. Methods. Patients were included in a 16-week control period followed by 16 weeks of high-intensity resistance training thrice weekly. IL-6 and 25-OH D were analysed after an over-night fast. Muscle fibre size was analysed in biopsies from m. vastus lateralis. Muscle power was tested using a Leg Extensor Power Rig. Results. Patients (n = 36) with IL-6 ≥ 6.49 pg/ml (median) were older and had decreased muscle power and a reduced protein intake (P < 0.05) compared with patients with IL-6 < 6.49 pg/ml. IL-6 was not associated with muscle fibre size. Vitamin D deficiency (25-OH D < 50 nmol/l) was present in 51% of the patients and not associated with muscle power. IL-6 remained unchanged during the training period, whilst muscle power increased by 20-23% (P < 0.001). Conclusion. Elevated IL-6 values were associated with decreased muscle power but not with decreased muscle fibre size. Half of the patients were suffering from vitamin D deficiency, which was not associated with muscle power. IL-6 was unchanged by high-intensity resistance training in dialysis patients in this study.
authors.affiliation: Department of Cardiology, Nephrology & Endocrinology, Nordsjællands University Hospital, Dyrehavevej 29, 3400 Hillerød, Denmark.
authors.forename: Stig
authors.initials: S
authors.lastname: Molsted
authors.affiliation: Department of Cardiology, Nephrology & Endocrinology, Nordsjællands University Hospital, Dyrehavevej 29, 3400 Hillerød, Denmark ; Faculty of Health and Medical Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
authors.forename: Pia
authors.initials: P
authors.lastname: Eiken
authors.affiliation: Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.
authors.forename: Jesper L
authors.initials: JL
authors.lastname: Andersen
authors.affiliation: Department of Nephrology P, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark.
authors.forename: Inge
authors.initials: I
authors.lastname: Eidemak
authors.affiliation: Department of Basic Animal and Veterinary Sciences, Faculty of Health and Medical Sciences, Copenhagen University, Grønnegårdsvej 15, 1870 Frederiksberg C, Denmark.
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Harrison
mesh_terms: D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009393:Nephritis / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control; D009929:Organ Size; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D055070:Resistance Training / Q000379:methods*; D016896:Treatment Outcome; D014807:Vitamin D / Q000097:blood*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014807:Vitamin D