title: Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial.
abstract: BACKGROUND
  Due to increasing resistance to antibiotics and rising incidence of oral diseases, there is a need for alternative treatment modalities to combat oral diseases. The aim of the present study was to access the effect of Aloe vera mouthwash on the dental plaque in the experimental period of 4 days and to compare it with the bench mark control chlorhexidine and placebo (saline water).
  
  
  METHODS
  A total of 300 systemically healthy subjects were randomly allocated into 3 groups: Aloe vera mouthwash group (n=100), control group (=100)-chlorhexidene group and saline water-Placebo (n=100). To begin with, Gingival index (GI) and plaque index (PI) were recorded. Then, baseline plaque scores were brought to zero by professionally cleaning the teeth with scaling and polishing. After randomization of the participants into three groups they were refrained from regular mechanical oral hygiene measures. Subjects were asked to swish with respective mouthwash (Aloe vera mouthwash, 0.2%chlorhexidine gluconate mouthwash, or normal saline) as per therapeutic dose for 4 days.
  
  
  RESULTS
  The results showed that Aloe vera mouthrinse is equally effective in reducing plaque as Chlorhexidine compared to placebo over a period of 4 days. There was a significant reduction on plaque in Aloe vera and chlorhexidine groups and no statistically significant difference was observed among them (p>0.05). Aloe vera mouthwash showed no side effects.
  
  
  CONCLUSIONS
  The results of the present study indicated that Aloe vera may prove an effective mouthwash due to its ability in reducing dental plaque.
authors.affiliation: Principal, Government Postgraduate College, Lansdowne, Uttrakhand, India.
authors.forename: Rajendra Kumar
authors.initials: RK
authors.lastname: Gupta
authors.affiliation: Department of Public Health Dentistry, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India.
authors.forename: Devanand
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Department of Public Health Dentistry, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India.
authors.forename: Dara John
authors.initials: DJ
authors.lastname: Bhaskar
authors.affiliation: Departmentof Orthodontics and Dentofacial Orthopedics, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Yadav
authors.affiliation: Departmentof Pedodontics and Preventive Dentistry, K.D Dental College and Hospital, Mathura, Uttar Pradesh, India.
authors.forename: Khursheed
authors.initials: K
authors.lastname: Obaid
authors.affiliation: Department of Prosthodontics, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Mishra
mesh_terms: D000293:Adolescent; D000328:Adult; D000504:Aloe; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000627:therapeutic use; D013335:Students, Dental / Q000706:statistics & numerical data; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D028321:Plant Preparations; D012965:Sodium Chloride; D002710:Chlorhexidine
keywords: Mouthwash; chlorhexidine; plaque