title: Design and fabrication of a biomimetic nanochannel for highly sensitive arginine response in serum samples.
abstract: Inspired from their biological counterparts, chemical modification of the interior surface of nanochannels with functional molecules may provide a highly efficient means to control ionic or molecular transport through nanochannels. Herein, we have designed and prepared a aldehyde calix[4]arene (C4AH), which was attached to the interior surface of a single nanochannel by using a click reaction, and that showed a high response for arginine (Arg). Furthermore, the nanofluidic sensing system has been challenged with complex matrices containing a high concentration of interfering sequences and serum. Based on this finding, we believe that the artificial nanochannel can be used for practical Arg-sensing devices, and be applied in a biological environment.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China).
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Song
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Sun
authors.forename: Cuiping
authors.initials: C
authors.lastname: Han
authors.forename: Demei
authors.initials: D
authors.lastname: Tian
authors.forename: Haibing
authors.initials: H
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D001120:Arginine / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D001120:Arginine
keywords: arginine; calixarene; click chemistry; nanochannel; sensor