title: The microenvironment matters: estrogen deficiency fuels cancer bone metastases.
abstract: Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.
authors.affiliation: Authors' Affiliations: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine; and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Wright
authors.affiliation: Authors' Affiliations: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine; and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IndianaAuthors' Affiliations: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine; and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana tguise@iu.edu.
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Guise
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D006801:Humans; D051379:Mice; D015663:Osteoporosis, Postmenopausal; D059016:Tumor Microenvironment
chemical_list: D004967:Estrogens