title: The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis.
abstract: Despite advances in antimicrobials, vaccination and public health measures, infectious diseases remain a leading cause of morbidity and mortality worldwide. With the increase in antimicrobial resistance and the emergence of new pathogens, there remains a need for new and more accurate diagnostics, the ability to monitor adequate treatment response as well as the ability to predict prognosis for an individual. Transcriptional approaches using blood signatures have enabled a better understanding of the host response to diseases, leading not only to new avenues of basic research, but also to the identification of potential biomarkers for use in diagnosis, prognosis and treatment monitoring.
authors.affiliation: Division of Immunoregulation, MRC National Institute for Medical Research, , London NW7 1AA, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Blankley
authors.forename: Matthew Paul Reddoch
authors.initials: MP
authors.lastname: Berry
authors.forename: Christine M
authors.initials: CM
authors.lastname: Graham
authors.forename: Chloe I
authors.initials: CI
authors.lastname: Bloom
authors.forename: Marc
authors.initials: M
authors.lastname: Lipman
authors.forename: Anne
authors.initials: A
authors.lastname: O'Garra
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003141:Communicable Diseases / Q000175:diagnosis* / Q000453:epidemiology* / Q000382:microbiology*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000502:physiology*; D006801:Humans; D049490:Systems Biology / Q000379:methods; D059467:Transcriptome / Q000235:genetics*; D014376:Tuberculosis / Q000235:genetics / Q000382:microbiology
chemical_list: D015415:Biomarkers
keywords: immune response; infection; tuberculosis