title: Integrated enrichment analysis and pathway-centered visualization of metabolomics, proteomics, transcriptomics, and genomics data by using the InCroMAP software.
abstract: In systems biology, the combination of multiple types of omics data, such as metabolomics, proteomics, transcriptomics, and genomics, yields more information on a biological process than the analysis of a single type of data. Thus, data from different omics platforms is usually combined in one experimental setup to obtain insight into a biological process or a disease state. Particularly high accuracy metabolomics data from modern mass spectrometry instruments is currently more and more integrated into biological studies. Reflecting this trend, we extended InCroMAP, a data integration, analysis and visualization tool for genomics, transcriptomics, and proteomics data. Now, the tool is able to perform an integrated enrichment analysis and pathway-based visualization of multi-omics data and thus, it is suitable for the evaluation of comprehensive systems biology studies.
authors.affiliation: Center for Bioinformatics, University of Tübingen, Tübingen, Germany. Electronic address: johannes.eichner@uni-tuebingen.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Eichner
authors.affiliation: Center for Bioinformatics, University of Tübingen, Tübingen, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Rosenbaum
authors.affiliation: Center for Bioinformatics, University of Tübingen, Tübingen, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Wrzodek
authors.affiliation: Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Germany.
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Häring
authors.affiliation: Center for Bioinformatics, University of Tübingen, Tübingen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zell
authors.affiliation: Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; Division of Clinical Chemistry and Pathobiochemistry, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Germany. Electronic address: rainer.lehmann@med.uni-tuebingen.de.
authors.forename: Rainer
authors.initials: R
authors.lastname: Lehmann
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D030541:Databases, Genetic; D046228:Microarray Analysis; D012984:Software; D014584:User-Computer Interface
keywords: Enrichment analysis; Genomics; Metabolomics; Pathway visualization; Proteomics; Transcriptomics