title: The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons.
abstract: Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is more complex and is currently a major focus of investigation. This review summarizes our current knowledge of the role of these cytokines in host defense against the bacterial pathogen Listeria monocytogenes and highlights recent discoveries on the molecular mechanisms evolved by this intracellular bacterium to subvert IFN responses.
authors.affiliation: Unité des Interactions Bactéries-Cellules, Institut Pasteur Paris, France ; Inserm, U604 Paris, France ; INRA, USC2020 Paris, France ; University of Paris Diderot, Sorbonne Paris Cité Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Dussurget
authors.affiliation: Unité des Interactions Bactéries-Cellules, Institut Pasteur Paris, France ; Inserm, U604 Paris, France ; INRA, USC2020 Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Bierne
authors.affiliation: Unité des Interactions Bactéries-Cellules, Institut Pasteur Paris, France ; Inserm, U604 Paris, France ; INRA, USC2020 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D008089:Listeria monocytogenes / Q000472:pathogenicity / Q000502:physiology*; D008088:Listeriosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*
chemical_list: D007372:Interferons
keywords: BAHD1; LntA; PgdA; immune escape; innate immunity; listeriosis