title: Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.
abstract: BACKGROUND
  Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits.
  
  
  OBJECTIVE
  The purpose of this study is to determine whether central nervous system serotonin influences the association between hostility and fasting glucose in African American women.
  
  
  METHODS
  The study consisted of 119 healthy volunteers (36 African American women, 27 White women, 21 White males, and 35 African American males, mean age 34 ± 8.5 years). Serotonin related compounds were measured in cerebrospinal fluid. Hostility was measured by the Cook-Medley Hostility Scale.
  
  
  RESULTS
  Hostility was associated with fasting glucose and central nervous system serotonin related compounds in African American women only. Controlling for the serotonin related compounds significantly reduced the association of hostility to glucose.
  
  
  CONCLUSIONS
  The positive correlation between hostility and fasting glucose in African American women can partly be explained by central nervous system serotonin function.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, BOX 3366, Durham, NC, 27710, USA, shboyle@duke.edu.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Boyle
authors.forename: Anastasia
authors.initials: A
authors.lastname: Georgiades
authors.forename: Beverly H
authors.initials: BH
authors.lastname: Brummett
authors.forename: John C
authors.initials: JC
authors.lastname: Barefoot
authors.forename: Ilene C
authors.initials: IC
authors.lastname: Siegler
authors.forename: Wayne R
authors.initials: WR
authors.lastname: Matson
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Kuhn
authors.forename: Katherine
authors.initials: K
authors.lastname: Grichnik
authors.forename: Mark
authors.initials: M
authors.lastname: Stafford-Smith
authors.forename: Redford B
authors.initials: RB
authors.lastname: Williams
authors.forename: Rima
authors.initials: R
authors.lastname: Kaddurah-Daouk
authors.forename: Richard S
authors.initials: RS
authors.lastname: Surwit
mesh_terms: D000328:Adult; D001741:Black or African American; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D006791:Hostility; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000134:cerebrospinal fluid*; D044465:White People; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D012701:Serotonin