title: Hepatoprotective effect of aged black garlic extract in rodents.
abstract: In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Jung Hyu
authors.initials: JH
authors.lastname: Shin
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Lee
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Oh
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Yun
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Moo Rim
authors.initials: MR
authors.lastname: Kang
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Han
authors.affiliation: Novarex Co., Ltd., Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Heungsik
authors.initials: H
authors.lastname: Park
authors.affiliation: Novarex Co., Ltd., Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Jae Chul
authors.initials: JC
authors.lastname: Jung
authors.affiliation: Namhaegun Blackgarlic Co., Ltd., 176-40, Seolcheon-ro, Seolcheon-myeon, Namhae-gun, Gyeongsangnam-do, Korea.
authors.forename: Yoon Hoo
authors.initials: YH
authors.lastname: Chung
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
authors.forename: Jong Soon
authors.initials: JS
authors.lastname: Kang
keywords: Aged black garlic; Carbon tetrachloride; D-galactosamine; Liver injury; Non-alcoholic fatty liver disease