title: Thyroid carcinoma surgery in children and adolescents - 15 years experience surgery of pediatric thyroid carcinoma.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the characteristics of thyroid gland surgery focusing on malignancies at the pediatric age with the main concern on treatment results and complications in extensive primary treatment.
  
  
  METHODS
  The records of all patients 18 years and younger with surgically treated thyroid diseases in the Prague Hospital, Motol, between 1991 and 2006 were retrospectively reviewed.
  
  
  RESULTS
  Thyroid surgery was performed on 148 pediatric patients (including 56 carcinomas). The youngest patient involved in the study was seven years old, the oldest patient 18 years old (mean 13.7 years). Most frequent histological cancer type was PTC (42 cases, 75%). Follicular cancer was diagnosed in five cases (8.9%) and medullar cancer in nine cases (16.1%). A prophylactic thyroidectomy was performed in three cases (5.4%) without clinical signs of thyroid tumor with diagnosed RET gene mutation.
  
  
  CONCLUSIONS
  We consider total thyroidectomy with subsequent radioiodine ablation and TSH suppression as the basic approach in the treatment protocol of pediatric WDTC. The observed 100% recurrence-free and overall survival together with a low incidence of postoperative complications strongly supports the idea of a total thyroidectomy with selective neck dissection in the treatment of metastases of WDTC and MTC.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, IPVZ, 1st Faculty, Charles University Hospital, Motol, Prague, Czech Republic; Department of Otorinolaryngology, 3rd Faculty of Medicine, Charles University, Motol, Prague, Czech Republic; Military Faculty Hospital, Motol, Prague, Czech Republic. Electronic address: jaromir.astl@seznam.cz.
authors.forename: Jaromír
authors.initials: J
authors.lastname: Astl
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, IPVZ, 1st Faculty, Charles University Hospital, Motol, Prague, Czech Republic; Institute of Anatomy (M.C.), 1st Faculty of Medicine, Charles University, Motol, Prague, Czech Republic; Center for Cell Therapy and Tissue Repair (M.C.), Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Motol, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Chovanec
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, IPVZ, 1st Faculty, Charles University Hospital, Motol, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Lukeš
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, 2nd Faculty, Charles University Prague, Motol, Prague, Czech Republic.
authors.forename: Rami
authors.initials: R
authors.lastname: Katra
authors.affiliation: Institute of Endocrinology (M.D.), Charles University, Motol, Prague, Czech Republic.
authors.forename: Marcela
authors.initials: M
authors.lastname: Dvořáková
authors.affiliation: Department of Nuclear Medicine (P.V., V.S.), Charles University, Motol, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Vlček
authors.affiliation: Department of Nuclear Medicine (P.V., V.S.), Charles University, Motol, Prague, Czech Republic.
authors.forename: Pavla
authors.initials: P
authors.lastname: Sýkorová
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, IPVZ, 1st Faculty, Charles University Hospital, Motol, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Betka
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000453:epidemiology; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009154:Mutation; D037981:Neck Dissection; D011183:Postoperative Complications / Q000453:epidemiology; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000706:statistics & numerical data*
chemical_list: D007457:Iodine Radioisotopes; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human
keywords: Adolescent; Carcinoma; Child; Neck dissection; Thyroidectomy