title: Systems biology of monovalent cation homeostasis in yeast: the translucent contribution.
abstract: Maintenance of monovalent cation homeostasis (mainly K(+) and Na(+)) is vital for cell survival, and cation toxicity is at the basis of a myriad of relevant phenomena, such as salt stress in crops and diverse human diseases. Full understanding of the importance of monovalent cations in the biology of the cell can only be achieved from a systemic perspective. Translucent is a multinational project developed within the context of the SysMO (System Biology of Microorganisms) initiative and focussed in the study of cation homeostasis using the well-known yeast Saccharomyces cerevisiae as a model. The present review summarize how the combination of biochemical, genetic, genomic and computational approaches has boosted our knowledge in this field, providing the basis for a more comprehensive and coherent vision of the role of monovalent cations in the biology of the cell.
authors.affiliation: Institut de Biotecnologia i Biomedicina & Dept. Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain. Electronic address: Joaquin.Arino@uab.es.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Ariño
authors.affiliation: Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom.
authors.forename: Ebru
authors.initials: E
authors.lastname: Aydar
authors.affiliation: Humboldt University, Berlin, Germany.
authors.forename: Samuel
authors.initials: S
authors.lastname: Drulhe
authors.affiliation: University Bonn, Bonn, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ganser
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Córdoba, Córdoba, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Jorrín
authors.affiliation: RheinAhrCampus, University of Applied Sciences Koblenz, Remagen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kahm
authors.affiliation: Humboldt University, Berlin, Germany.
authors.forename: Falko
authors.initials: F
authors.lastname: Krause
authors.affiliation: Institut de Biotecnologia i Biomedicina & Dept. Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Petrezsélyová
authors.affiliation: Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, Valencia, Spain.
authors.forename: Lynne
authors.initials: L
authors.lastname: Yenush
authors.affiliation: Department of Membrane Transport, Institute of Physiology Academy of Sciences CR, Prague, Czech Republic.
authors.forename: Olga
authors.initials: O
authors.lastname: Zimmermannová
authors.affiliation: Institute of Biology, Leiden University, Leiden, The Netherlands.
authors.forename: G Paul H
authors.initials: GP
authors.lastname: van Heusden
authors.affiliation: RheinAhrCampus, University of Applied Sciences Koblenz, Remagen, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Kschischo
authors.affiliation: University Bonn, Bonn, Germany.
authors.forename: Jost
authors.initials: J
authors.lastname: Ludwig
authors.affiliation: Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom.
authors.forename: Chris
authors.initials: C
authors.lastname: Palmer
authors.affiliation: Department of Microbiology, University of Córdoba, Córdoba, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Ramos
authors.affiliation: Department of Membrane Transport, Institute of Physiology Academy of Sciences CR, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Sychrová
mesh_terms: D001692:Biological Transport; D002414:Cations, Monovalent / Q000378:metabolism; D006706:Homeostasis; D011188:Potassium / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D049490:Systems Biology
chemical_list: D002414:Cations, Monovalent; D029701:Saccharomyces cerevisiae Proteins; D012964:Sodium; D011188:Potassium
keywords: Cation transport; Potassium homeostasis; Saccharomyces cerevisiae; Salt stress; Systems biology