title: [Treatment of cerebral palsy children by integrative medical sequential method: a clinical efficacy observation].
abstract: OBJECTIVE
  To observe the efficacy of integrative medical sequential method in treating cerebral palsy (CP) children's intelligence development, muscular tension, serum interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).
  
  
  METHODS
  Totally 111 CP children were randomly assigned to the control group (50 cases) and the treatment group (61 cases). All patients received comprehensive rehabilitation training and intravenous dripping of Monosialotetrahexosylganglioside Sodium Injection for 10 days. But those in the treatment group additionally received Chinese medical enema for brain resuscitation, relieving rigidity of muscles and activating collaterals for 14 days. Then they started another medication cycle and lasted for a total of 6 cycles. Serum IL-6 levels and TNF-alpha contents were determined before treatment. Scoring for muscular tension, Gesell score for intelligence development, contents of serum IL-6 and TNF-alpha were assessed before and after treatment in the two groups.
  
  
  RESULTS
  Compared with before treatment in this group, muscular tension, Gesell scores for intelligence development all decreased in the two groups (P < 0.05). As for inter-group comparison, the decrement was more obvious in the treatment group than in the control group (P < 0.05). The total effective rate was 86.9% in the treatment group and 76.0% in the control group (P < 0.05). The contents of IL-6 and TNF-alpha were obviously reduced in the treatment group and the control group after treatment (P < 0.01). The decrement was more obvious in the treatment group (P < 0.05).
  
  
  CONCLUSIONS
  The two treatment methods were effective for CP children, but the efficacy was superior in the treatment group than in the control group, indicating integrative medical methods could play a synergistic effect and optimize the treatment program for CP.
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiao-Cong
authors.initials: XC
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhao
mesh_terms: D002547:Cerebral Palsy / Q000188:drug therapy*; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005732:Gangliosides / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D055048:Integrative Medicine; D007360:Intelligence; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D005732:Gangliosides; C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha