title: Statins improve survival in patients with cardioembolic stroke.
abstract: OBJECTIVE
  The objective of this study was to investigate the potential benefits of statin therapy on mortality and stroke recurrence after cardioembolic stroke.
  
  
  METHODS
  In this retrospective observational study, we analyzed data from 535 patients with first-ever cardioembolic stroke. Patients were classified into nonstatin, low-potency statin, and high-potency statin groups. The primary outcomes were time to mortality and time to recurrent stroke.
  
  
  RESULTS
  The mean duration of follow-up was 22.2 months. The cumulative mortality rate was 7% at the end of the first year and 10% at the end of the third year. Statin therapy was independently associated with reduced mortality (hazard ratio, 0.237; 95% confidence interval, 0.080-0.703 for nonstatin versus low-potency statin; hazard ratio, 0.158; 95% confidence interval, 0.037-0.686 for nonstatin versus high-potency statin). Statin treatment did not affect the incidence of recurrent stroke in patients with cardioembolic stroke.
  
  
  CONCLUSIONS
  Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
authors.forename: Jeong-Yoon
authors.initials: JY
authors.lastname: Choi
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.). nukseo@korea.ac.kr.
authors.forename: Woo-Keun
authors.initials: WK
authors.lastname: Seo
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kang
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
authors.forename: Jin-Man
authors.initials: JM
authors.lastname: Jung
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Cho
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
authors.forename: Sungwook
authors.initials: S
authors.lastname: Yu
authors.affiliation: From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
authors.forename: Kyungmi
authors.initials: K
authors.lastname: Oh
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D020766:Intracranial Embolism / Q000188:drug therapy* / Q000401:mortality*; D008297:Male; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy* / Q000401:mortality*; D015996:Survival Rate
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: embolism; mortality; outcome; recurrence; statin; stroke