title: Web-based workflow planning platform supporting the design and execution of complex multiscale cancer models.
abstract: Significant Virtual Physiological Human efforts and projects have been concerned with cancer modeling, especially in the European Commission Seventh Framework research program, with the ambitious goal to approach personalized cancer simulation based on patient-specific data and thereby optimize therapy decisions in the clinical setting. However, building realistic in silico predictive models targeting the clinical practice requires interactive, synergetic approaches to integrate the currently fragmented efforts emanating from the systems biology and computational oncology communities all around the globe. To further this goal, we propose an intelligent graphical workflow planning system that exploits the multiscale and modular nature of cancer and allows building complex cancer models by intuitively linking/interchanging highly specialized models. The system adopts and extends current standardization efforts, key tools, and infrastructure in view of building a pool of reliable and reproducible models capable of improving current therapies and demonstrating the potential for clinical translation of these technologies.
authors.forename: Vangelis
authors.initials: V
authors.lastname: Sakkalis
authors.forename: Stelios
authors.initials: S
authors.lastname: Sfakianakis
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Tzamali
authors.forename: Kostas
authors.initials: K
authors.lastname: Marias
authors.forename: Georgios
authors.initials: G
authors.lastname: Stamatakos
authors.forename: Fay
authors.initials: F
authors.lastname: Misichroni
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Ouzounoglou
authors.forename: Eleni
authors.initials: E
authors.lastname: Kolokotroni
authors.forename: Dimitra
authors.initials: D
authors.lastname: Dionysiou
authors.forename: David
authors.initials: D
authors.lastname: Johnson
authors.forename: Steve
authors.initials: S
authors.lastname: McKeever
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
mesh_terms: D003198:Computer Simulation; D006801:Humans; D020407:Internet; D008954:Models, Biological; D009369:Neoplasms; D057285:Precision Medicine; D015398:Signal Transduction; D012984:Software; D049490:Systems Biology / Q000379:methods*; D014584:User-Computer Interface