title: Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses.
abstract: Oncolytic viruses (OVs) preferentially infect and kill cancer cells. Additionally, OV-induced immune responses subvert cancer-associated immunosuppression and promote antitumor immunity. We have recently demonstrated that the complementation of oncolytic virotherapy with gemcitabine accentuates its immunostimulatory effects, hence exerting superior antineoplastic activity.
authors.affiliation: Department of Microbiology and Immunology; Dalhousie University; Halifax, NS Canada ; Strategy & Organizational Performance; IWK Health Centre; Halifax, NS Canada.
authors.forename: Shashi A
authors.initials: SA
authors.lastname: Gujar
authors.affiliation: Department of Pathology; Dalhousie University; Halifax, NS Canada.
authors.forename: Derek
authors.initials: D
authors.lastname: Clements
authors.affiliation: Department of Microbiology and Immunology; Dalhousie University; Halifax, NS Canada ; Department of Pathology; Dalhousie University; Halifax, NS Canada.
authors.forename: Patrick Wk
authors.initials: PW
authors.lastname: Lee
keywords: MDSCs; antitumor immunity; gemcitabine; immune evasion; oncolytic virus; reovirus; tumor microenvironment