title: Segmental and global left ventricular function assessment using gated SPECT with a semiconductor Cadmium Zinc Telluride (CZT) camera: phantom study and clinical validation vs cardiac magnetic resonance.
abstract: BACKGROUND
  We evaluated gated-SPECT using a Cadmium-Zinc-Telluride (CZT) camera for assessing global and regional left ventricular (LV) function.
  
  
  METHODS
  A phantom study evaluated the accuracy of wall thickening assessment using systolic count increase on both Anger and CZT (Discovery 530NMc) cameras. The refillable phantom simulated variable myocardial wall thicknesses. The apparent count increase (%CI) was compared to the thickness increase (%Th). CZT gated-SPECT was compared to cardiac magnetic resonance (CMR) in 27 patients. Global and regional LV function (wall thickening and motion) were quantified and compared between SPECT and CMR data.
  
  
  RESULTS
  In the phantom study using a 5-mm object, the regression between %CI and %Th was significantly closer to the line of identity (y = x) with the CZT (R (2) = 0.9955) than the Anger (R (2) = 0.9995, P = .03). There was a weaker correlation for larger objects (P = .003). In patients, there was a high concordance between CZT and CMR for ESV, EDV, and LVEF (all CCC >0.80, P < .001). CZT underestimated %CI and wall motion (WM) compared to CMR (P < .001). The agreement to CMR was better for WM than wall thickening.
  
  
  CONCLUSIONS
  The Discovery 530NMc provided accurate measurements of global LV function but underestimated regional wall thickening, especially in patients with increased wall thickness.
authors.affiliation: Nuclear Medicine Department, IRIS, Polyclinique du Bois, 144 avenue de Dunkerque, 59000, Lille, France, abailliez@gmail.com.
authors.forename: Alban
authors.initials: A
authors.lastname: Bailliez
authors.forename: Tanguy
authors.initials: T
authors.lastname: Blaire
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mouquet
authors.forename: R
authors.initials: R
authors.lastname: Legghe
authors.forename: B
authors.initials: B
authors.lastname: Etienne
authors.forename: Damien
authors.initials: D
authors.lastname: Legallois
authors.forename: Denis
authors.initials: D
authors.lastname: Agostini
authors.forename: Alain
authors.initials: A
authors.lastname: Manrique
mesh_terms: D000368:Aged; D002104:Cadmium; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016277:Ventricular Function, Left; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D015032:Zinc; D013691:Tellurium