title: Macro and small over micro: macromolecules and small molecules that regulate microRNAs.
abstract: Given the correlation between the deregulation of specific miRNAs and disease onset, it is critical to identify miRNA regulators that effectively control miRNAs involved in the pathogenesis of target diseases. This review provides the latest update on oligonucleotide- and small-molecule-based miRNA regulators, and discusses assays developed to screen for small-molecule regulators.
authors.affiliation: Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea).
authors.forename: Soowon
authors.initials: S
authors.lastname: Kang
authors.forename: Kyungtaek
authors.initials: K
authors.lastname: Im
authors.forename: Jihae
authors.initials: J
authors.lastname: Baek
authors.forename: Sungroh
authors.initials: S
authors.lastname: Yoon
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Min
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry / Q000494:pharmacology*; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology*; D015203:Reproducibility of Results; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D013379:Substrate Specificity
chemical_list: D046911:Macromolecular Substances; D035683:MicroRNAs; D016376:Oligonucleotides, Antisense; D054852:Small Molecule Libraries
keywords: RNA; high-throughput screening; microRNAs; regulators; small molecules