title: Choroidal metastasis from leiomyosarcoma in two cases.
abstract: Leiomyosarcoma is a malignant tumor of mesenchymal cells and is the most common soft-tissue sarcoma. Leiomyosarcoma is a notably rare tumor in the ophthalmic region and can be of primary, secondary or metastatic origin. To the best of our knowledge, there has only been one published case of leiomyosarcoma metastasis to the choroid. In this case study, we report two cases of primary leiomyosarcoma with metastasis to the choroid of the eye. Both cases displayed systemic metastasis and showed response to high dose plaque radiotherapy. Despite its prevalence as the leading form of sarcoma, leiomyosarcoma rarely metastasizes to the ocular region.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, IL, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Feinstein
authors.affiliation: Ocular Oncology Service, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Swathi
authors.initials: S
authors.lastname: Kaliki
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University Philadelphia, PA, USA.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.affiliation: Department of Pathology, Fox Chase Center, Philadelphia, PA, USA.
authors.forename: Hormoz
authors.initials: H
authors.lastname: Ehya
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University Philadelphia, PA, USA.
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
keywords: Choroid; eye; fine needle aspiration biopsy; leiomyosarcoma; metastasis; sarcoma; tumor; uvea