title: Suppressive effects of D-glucosamine on the 5-HT sensitive nociceptive units in the rat tooth pulpal nerve.
abstract: It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about the characteristics of the effects of this compound on dental pain. The present study was undertaken to evaluate the applicability of DGL as a medicament to control pulpalgia. Using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), we evaluated the effects of DGL on 5-hydroxytryptamine (5-HT) sensitive nociceptive responses in the tooth pulpal nerve. 5-HT-induced nociceptive responses were fairly suppressed by direct application of DGL, suggesting that DGL have a pain relief effect on patients with dental pain.
authors.affiliation: Department of Cariology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan ; Department of Integrative Sensory Physiology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Kaida
authors.affiliation: Department of Integrative Sensory Physiology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan ; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yamashita
authors.affiliation: Department of Integrative Sensory Physiology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Toda
authors.affiliation: Department of Cariology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8588, Japan.
authors.forename: Yoshihiko
authors.identifier: 0000-0002-4256-3085
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000200:Action Potentials; D000818:Animals; D003782:Dental Pulp / Q000187:drug effects* / Q000294:innervation*; D005944:Glucosamine / Q000494:pharmacology*; D008297:Male; D009417:Nerve Tissue / Q000187:drug effects / Q000502:physiology*; D059225:Nociception / Q000187:drug effects*; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D012701:Serotonin; D005944:Glucosamine