title: Adenosine-induced cardiac arrest in complex cerebral aneurysms surgery: an Italian single-center experience.
abstract: OBJECTIVE
  Even if endovascular techniques are improving, treatment of complex intracranial aneurysms still remains a neurosurgeon challenge. Adenosine administration, producing a brief and profound systemic hypotension, seems to improve surgical aneurysm visualization facilitating its exclusion with less risks of rupture. In our retrospective study we confirmed that adenosine advantages could be determinant for an optimal surgical result.
  
  
  METHODS
  We retrospectively reviewed all unruptured complex cerebral aneurysms surgically treated in our institution between August 2009 and April 2012. Treatment of those aneurysms was surgical, with proximal temporary artery occlusion or adenosine induced flow arrest. We compared the two different techniques, evaluating intra- and postoperative data; a three-month follow-up including a neurological assessment, cerebral angiography and echocardiography for the adenosine group was performed.
  
  
  RESULTS
  Twenty-four patients were collected in our study. Eleven patients underwent traditional temporary proximal clipping while in 13 patients intraoperative adenosine was used. Most common location was paraclinoid region. We did not observe any complication in the adenosine group. Adenosine was well tolerated, spontaneous recovery of sinusal cardiac rhythm was observed even at high and subsequent doses. The Intensive Care Unit and Hospital length of stay were shorter in adenosine group. A three-month follow-up did not show cardiac abnormalities with good angiographic aneurysms exclusion.
  
  
  CONCLUSIONS
  We observed that adenosine administration allowed an easier clipping thanks to a reduced wall tension in a clearer surgical field without cardiological adverse events. In our opinion adenosine induced arrest technique could be an efficacious, harmless and reliable alternative strategy for surgical treatment of complex cerebral aneurysms.
authors.affiliation: Division of Neurosurgery, Department of Surgery CTO Hospital, Turin, Italy - carloalbertobenech@hotmail.com.
authors.forename: C A
authors.initials: CA
authors.lastname: Benech
authors.forename: R
authors.initials: R
authors.lastname: Perez
authors.forename: G
authors.initials: G
authors.lastname: Faccani
authors.forename: A C
authors.initials: AC
authors.lastname: Trompeo
authors.forename: S
authors.initials: S
authors.lastname: Cavallo
authors.forename: S
authors.initials: S
authors.lastname: Beninati
authors.forename: M
authors.initials: M
authors.lastname: Berardino
mesh_terms: D000241:Adenosine / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods; D017542:Aneurysm, Ruptured / Q000517:prevention & control*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D012189:Retrospective Studies; D013525:Surgical Instruments; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine