title: Specific abnormalities versus number of abnormalities and cytogenetic scoring systems for outcome prediction after allogeneic hematopoietic SCT for myelodysplastic syndromes.
abstract: Newer cytogenetic scoring systems for myelodysplastic syndromes (MDSs), like cytogenetic stratification of the revised international prognostic scoring system (IPSS-R) or monosomal karyotype, may also improve outcome prediction after hematopoietic SCT (HCT). We compared the prognostic value of specific cytogenetic abnormalities, IPSS-R karyotype and monosomal karyotype for HCT outcome in 98 patients with MDS and AML post MDS. Higher-risk IPSS-R karyotype, 3q21q26 and transformation to AML before HCT were associated with increased cumulative incidence of relapse (CIR), whereas OS was adversely influenced by del 5q/-5, abnormalities of chromosomes 11 and 17 and cytogenetic IPSS-R very poor category. Karyotype with ⩽2 abnormalities and no abnormalities of chromosomes 3, 5, 7, 11 and 17 was an independent prognostic factor of lower CIR (hazard ratio (HR)=0.2, P=0.01) and longer OS (HR=0.5, P=0.03). In conclusion, some specific cytogenetic abnormalities and high cytogenetic complexity, as reflected by IPSS-R very poor karyotype, rather than monosomal karyotype, were associated with higher CIR and shorter OS after HCT. Conversely, results were encouraging in patients lacking those abnormalities, who may be very good candidates for HCT.
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Kelaidi
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Tzannou
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Baltadakis
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Batsis
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Mallouri
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Spyridonidis
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Gigantes
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Tsirigotis
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Apostolidis
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Athanasiadou
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Manola
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Anagnostopoulos
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Harhalakis
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Sakellari
authors.affiliation: Hematology Department and Bone Marrow Transplantation Unit, G. Papanicolaou Hospital, Exochi, Thessaloniki, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Karakasis
mesh_terms: D059786:Abnormal Karyotype; D000328:Adult; D064591:Allografts; D002877:Chromosomes, Human / Q000235:genetics*; D018572:Disease-Free Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate