title: High-throughput screening of pesticide and veterinary drug residues in baby food by liquid chromatography coupled to quadrupole Orbitrap mass spectrometry.
abstract: A new analytical method was developed and validated for simultaneous analysis of 333 pesticide and veterinary drug residues in baby food. Response surface methodology was employed to optimize a generic extraction method. Ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-ESI Q-Orbitrap) was used for the separation and detection of all the analytes. The method was validated by taking into consideration the guidelines specified in Commission Decision 2002/657/EC and SANCO/12571/2013. The extraction recoveries were in a range of 79.8-110.7%, with coefficient of variation <8.3%. The 333 compounds behave dynamic in the range 0.1-1000μgkg(-1) concentration, with correlation coefficient >0.99. The limits of detection for the analytes are in the range 0.01-5.35μgkg(-1). The limits of quantification for the analytes are in the range 0.01-9.27μgkg(-1). This method has been successfully applied on screening of pesticide and veterinary drugs in ninety-three commercial baby food samples, and tilmicosin, fenbendazole, tylosin tartrate and thiabendazole were detected in some samples tested in this study. The present study is very useful for fast screening of different food contaminants.
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China; Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China; Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China. Electronic address: foodjiawei@aliyun.com.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chu
authors.affiliation: Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China.
authors.forename: Junrong
authors.initials: J
authors.lastname: Huang
authors.affiliation: Thermo Fisher Scientific, 355 River Oaks Parkway, San Jose, CA 95134, USA.
authors.forename: James
authors.initials: J
authors.lastname: Chang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis*; D005506:Food Contamination; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D010575:Pesticides / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization; D019155:Veterinary Drugs / Q000032:analysis*
chemical_list: D010573:Pesticide Residues; D010575:Pesticides; D019155:Veterinary Drugs
keywords: Baby food; Multi-residue methods; Q-Orbitrap; Targeted-screening; Validation