title: CeasIng Cpap At standarD criteriA (CICADA): impact on weight gain, time to full feeds and caffeine use.
abstract: BACKGROUND
  In our previous randomised controlled trial (RCT), we have shown in preterm babies (PBs) <30 weeks gestation that CeasIng Cpap At standarD criteriA (CICADA (method 1)) compared with cycling off continuous positive airway pressure (CPAP) gradually (method 2) or cycling off CPAP gradually with low flow air/oxygen during periods off CPAP (method 3) reduces CPAP cessation time in PBs <30 weeks gestation.
  
  
  METHODS
  This retrospective study reviewed weight gain, time to reach full feeds and time to cease caffeine in PBs previously enrolled in the RCT.
  
  
  RESULTS
  Data were collected from 162 of the 177 PBs, and there was no significant difference in the projected weight gain between the three methods. Based on intention to treat, the time taken to reach full feeds for all three methods showed no significant difference. However, post hoc analysis showed the CICADA method compared with cycling off gradually just failed significance (30.3±1.6 vs 31.1±2.4 (weeks corrected gestational age (Wks CGA±SD)), p=0.077). Analysis of time to cease caffeine showed there was a significant difference between the methods with PBs randomised to the CICADA method compared with the cycling off method ceasing caffeine almost a week earlier (33.6±2.4 vs 34.5±2.8 (Wks CGA±SD), p=0.02).
  
  
  CONCLUSIONS
  This retrospective study provides evidence to substantiate the optimum method of ceasing CPAP; the CICADA method, does not adversely affect weight gain, time to reach full feeds and may reduce time to cease caffeine in PBs <30 weeks gestation.
authors.affiliation: Department of Neonatology, Canberra Hospital, Garran, Australian Capital Territory, Australia.
authors.forename: Margaret
authors.initials: M
authors.lastname: Broom
authors.affiliation: Australian National University Medical School, Canberra, Australian Capital Territory, Australia.
authors.forename: Lei
authors.initials: L
authors.lastname: Ying
authors.affiliation: Centre for Newborn Care, Westmead Hospital, Westmead, New South Wales, Australia.
authors.forename: Audrey
authors.initials: A
authors.lastname: Wright
authors.affiliation: Grantley Stable Neonatal Intensive Care Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: Alice
authors.initials: A
authors.lastname: Stewart
authors.affiliation: Department of Neonatology, Canberra Hospital, Garran, Australian Capital Territory, Australia Australian National University Medical School, Canberra, Australian Capital Territory, Australia.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Abdel-Latif
authors.affiliation: Centre for Advances in Epidemiology and IT, Canberra Hospital, Garran, Australian Capital Territory, Australia.
authors.forename: Bruce
authors.initials: B
authors.lastname: Shadbolt
authors.affiliation: Department of Neonatology, Canberra Hospital, Garran, Australian Capital Territory, Australia Australian National University Medical School, Canberra, Australian Capital Territory, Australia.
authors.forename: David A
authors.initials: DA
authors.lastname: Todd
mesh_terms: D001034:Apgar Score; D001724:Birth Weight / Q000502:physiology; D002110:Caffeine / Q000008:administration & dosage*; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D004334:Drug Administration Schedule; D004750:Enteral Nutrition; D005260:Female; D005865:Gestational Age; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000379:methods; D012189:Retrospective Studies; D013997:Time Factors; D015300:Ventilator Weaning / Q000379:methods*; D015430:Weight Gain / Q000502:physiology*
chemical_list: D002110:Caffeine
keywords: Neonatology; Respiratory