title: [The role of transforming growth factor beta1 R II and interleukin 13 Ralpha2 in schistosomiasis-induced hepatic fibrosis].
abstract: Schistosomiasis hepatic fibrosis results from excessive deposition of extracellular matrix components which are produced from the activated hepatic stellate cells in liver. Cytokine network disorder is the essential cause of the development of schistosomiasis liver fibrosis. Transforming growth factor beta1 (TGF-beta1) and interleukin 13 (IL-13) promote fibrosis through hepatic stellate cell membrane-specific receptor. This paper reviews the effects of TGF-beta1 type II (TGF-beta1 R II) receptor and IL-13 receptor alpha2 (IL-13 Ralpha2) on hepatic fibrosis.
authors.forename: Chao-Qun
authors.initials: CQ
authors.lastname: Zhou
authors.forename: Yong-Yang
authors.initials: YY
authors.lastname: Wang
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000818:Animals; D006801:Humans; D053663:Interleukin-13 Receptor alpha2 Subunit / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000469:parasitology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D012552:Schistosomiasis / Q000378:metabolism* / Q000473:pathology
chemical_list: D053663:Interleukin-13 Receptor alpha2 Subunit; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II