title: Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers.
abstract: Ethnopharmacological Relevance. TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes. Aim of the Study. This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose. Methods. The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers. Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects. Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect. Results. 3 and 4 tablets of TZQ decreased the C max of plasma glucose compared with that of the previous day and with placebo. 3 tablets also decreased C max of plasma C-peptide compared with placebo. 4 tablets increased C max of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner. 2 tablets did not decrease plasma glucose and elevated the C max and AUC of C-peptide after breakfast and dinner, respectively. Acarbose 50 mg decreased the C max of plasma insulin and C-peptide after breakfast and the C max of plasma glucose and C-peptide after dinner. The subjects who received TZQ did not report any abdominal adverse events. Conclusions. 3 tablets of TZQ have the same effects as the acarbose.
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Yuhong
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Wenxu
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yanfen
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Liu
authors.identifier: 0000-0002-2294-2192
authors.initials: L
authors.lastname: Yu
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ziqiang
authors.affiliation: Tasly Research Institute, Tasly Pharmaceutical Group Co., Ltd., No. 2 Pujihe East Road, Beichen District, Tianjin 300041, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Shirong
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Jinxia
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Li
authors.initials: L
authors.lastname: Na
authors.affiliation: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Baohe
authors.affiliation: Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Gao
authors.initials: G
authors.lastname: Xiumei
authors.affiliation: Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Deqin