title: [Preliminary application of injectable calcium phosphate cement/poly (lactic-co-glycolic acid) microspheres for extraction site preservation].
abstract: OBJECTIVE
  To investigate the feasibility of extraction site preservation using injectable calcium phosphate cement (CPC) combine with poly (lactic-co-glycolic acid) (PLGA) microspheres.
  
  
  METHODS
  Immediate extraction defects models were created in canine mandibles, and the defects were filled with CPC/PLGA (experimental group, E) , Bio-Oss (positive control, P), non-treatment (blank control, B) respectively. Dogs were sacrificed after 4, 8, 12 weeks post operation. Statistical analysis were conducted using SPSS 19.
  
  
  RESULTS
  of radiological observation showed that there were not significantly different between groups in 4 and 8 week (P > 0.05). After 12 week,E (114.9 ± 8.4) were not significantly different compared with P (117.4 ± 12.1) (P > 0.05) , both were significantly higher than B (95.0 ± 12.6) (P < 0.05) . Histology examination showed that at 4 week following surgery, the result of newly formed bone was as follow, P[ (87.5 ± 1.5) %] > B[(78.7 ± 2.7)%] > E[(69.2 ± 1.8)%] (P < 0.05). At 8, 12 week, results of P[(94.0 ± 2.3)% and (93.5 ± 1.9) %] and E[ (94.7 ± 1.1) % and (96.0 ± 0.9) %] were better than those of B[ (76.8 ± 3.0)% and (87.0 ± 2.4)%] (P < 0.05).
  
  
  CONCLUSIONS
  The effect of CPC/PLGA repair immediate alveolar ridge defects is the same as that of Bio-Oss, and CPC/PLGA can be used as a material in extraction site preservation.
authors.affiliation: Department of Prosthodontics, College of Stomatology, Guangxi Medical University, Nanning 530021, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Mai
authors.affiliation: Department of Prosthodontics, College of Stomatology, Guangxi Medical University, Nanning 530021, China.
authors.forename: Huihuang
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Prosthodontics, College of Stomatology, Guangxi Medical University, Nanning 530021, China.
authors.forename: Zhisong
authors.initials: Z
authors.lastname: Mai
authors.affiliation: Department of Prosthodontics, College of Stomatology, Guangxi Medical University, Nanning 530021, China.
authors.forename: Xinghong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Prosthodontics, College of Stomatology, Guangxi Medical University, Nanning 530021, China.
authors.forename: Linhui
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Prosthodontics, College of Stomatology, Guangxi Medical University, Nanning 530021, China. Email: dr_liaohb2005@126.com.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Liao
mesh_terms: D000818:Animals; D002130:Calcium Phosphates; D003738:Dental Cements; D004285:Dogs; D006016:Glycolates; D019344:Lactic Acid; D008863:Microspheres; D008903:Minerals; D003765:Models, Dental; D011091:Polyesters; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D014081:Tooth Extraction
chemical_list: C077540:Bio-Oss; D002130:Calcium Phosphates; D003738:Dental Cements; D006016:Glycolates; D008903:Minerals; D011091:Polyesters; D011108:Polymers; C031149:glycolic acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); C020243:calcium phosphate