title: A naturally occurring CD8(+)CD122(+) T-cell subset as a memory-like Treg family.
abstract: Despite extensive studies on CD4(+)CD25(+) regulatory T cells (Tregs) during the past decade, the progress on their clinical translation remains stagnant. Mounting evidence suggests that naturally occurring CD8(+)CD122(+) T cells are also Tregs with the capacity to inhibit T-cell responses and suppress autoimmunity as well as alloimmunity. In fact, they are memory-like Tregs that resemble a central memory T cell (TCM) phenotype. The mechanisms underlying their suppression are still not well understood, although they may include IL-10 production. We have recently demonstrated that programmed death-1 (PD-1) expression distinguishes between regulatory and memory CD8(+)CD122(+) T cells and that CD8(+)CD122(+) Tregs undergo faster homeostatic proliferation and are more potent in the suppression of allograft rejection than conventional CD4(+)CD25(+) Tregs. These findings may open a new line of investigation for accelerating effective Treg therapies in the clinic. In this review, we summarize the significant progress in this promising field of CD8(+)CD122(+) Treg research and discuss their phenotypes, suppressive roles in autoimmunity and alloimmunity, functional requirements, mechanisms of action and potential applications in the clinic.
authors.affiliation: Section of Immunology, Center for Regenerative and Translational Medicine.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.affiliation: Section of Immunology, Center for Regenerative and Translational Medicine.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Zou
authors.affiliation: Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Section of Immunology, Center for Regenerative and Translational Medicine.
authors.forename: Shouhai
authors.initials: S
authors.lastname: Wu
authors.affiliation: Section of Immunology, Center for Regenerative and Translational Medicine.
authors.forename: Haixia
authors.initials: H
authors.lastname: Deng
authors.affiliation: Section of Immunology, Center for Regenerative and Translational Medicine.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Immunobiology and Transplantation Research Center, Houston Methodist Research Institute, Houston, TX, USA.
authors.forename: Xian C
authors.initials: XC
authors.lastname: Li
authors.affiliation: Section of Immunology, Center for Regenerative and Translational Medicine.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D016753:Interleukin-10 / Q000378:metabolism; D053646:Interleukin-2 Receptor beta Subunit; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D016827:CD8 Antigens; D053646:Interleukin-2 Receptor beta Subunit; D061026:Programmed Cell Death 1 Receptor; D016753:Interleukin-10