title: [Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options].
abstract: In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell activation disease, as well as to counsel a personalized drug therapy. In the case of chronic multisystem polymorbidity systemic mast cell activation disease should be considered as a differential diagnosis at an early stage. In most cases, specific, little invasive investigations allow diagnosing the disease and, hence, an appropriate therapy can be initiated.
authors.affiliation: Institut für Humangenetik, Universitätsklinikum Bonn.
authors.forename: G J
authors.initials: GJ
authors.lastname: Molderings
authors.affiliation: Abteilung für Innere Medizin, Gemeinschaftskrankenhaus Bonn.
authors.forename: J
authors.initials: J
authors.lastname: Homann
authors.affiliation: Klinik für Onkologie, Hämatologie und Palliativmedizin, Kreiskrankenhaus Waldbröl.
authors.forename: S
authors.initials: S
authors.lastname: Brettner
authors.affiliation: Medizinische Klinik 1, Universitätsklinikum Erlangen.
authors.forename: M
authors.initials: M
authors.lastname: Raithel
authors.affiliation: Medizinische Klinik II, HELIOS Klinikum Krefeld.
authors.forename: T
authors.initials: T
authors.lastname: Frieling
mesh_terms: D000328:Adult; D000465:Algorithms; D001205:Ascorbic Acid / Q000008:administration & dosage; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D003131:Combined Modality Therapy; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007665:Ketotifen / Q000008:administration & dosage; D008407:Mast Cells / Q000473:pathology; D034721:Mastocytosis, Systemic / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D011247:Pregnancy; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011899:Ranitidine / Q000008:administration & dosage
chemical_list: D006634:Histamine H1 Antagonists; D012333:RNA, Messenger; D011899:Ranitidine; D019009:Proto-Oncogene Proteins c-kit; D001205:Ascorbic Acid; D007665:Ketotifen