title: [Severe drug-induced skin reactions. Stevens-Johnson syndrome and toxic epidermal necrolysis].
abstract: Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are characterized by extensive blistering of the skin and mucosa; they are considered as one disease entity with varying severity. They are rare but potentially life-threatening and accompanied by high mortality. A clear clinical diagnosis is needed to direct specific therapy, but supportive therapy remains most important. In order to identify and withdraw the inducing drug, a very detailed and thorough medication history has to be obtained. Among the highly suspected (strongly associated) agents are allopurinol, antibacterial sulfonamides, non-steroidal anti-inflammatory drugs of the oxicam type, various anti-epileptics and nevaripine. Together they account for more than half of the cases of SJS/TEN. Although a drug is not always the cause, it is considered very like in approximately 75% of cases. Infections have also to be considered as etiologic factors.
authors.affiliation: Dokumentationszentrum schwerer Hautreaktionen (dZh), Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland, dzh@uniklinik-freiburg.de.
authors.forename: M
authors.initials: M
authors.lastname: Mockenhaupt
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008487:Medical History Taking / Q000379:methods*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000628:therapy*