title: Influence of an oral contraceptive containing drospirenone on insulin sensitivity of healthy women.
abstract: OBJECTIVE
  Oral contraceptives (OCs) containing androgenic second and third generation progestins decrease insulin sensitivity (SI). In this study we investigated whether an oral contraceptive containing the anti-androgenic progestin drospirenone (DRSP) still alters SI. Lipid modifications were investigated as well.
  
  
  METHODS
  Eleven young healthy women were allocated to receive for 6 months ethinyl-estradiol (EE) 30μg plus DRSP (3mg). SI and glucose utilization independent of insulin (Sg) was investigated by the minimal model method. Lipid modifications were also analyzed.
  
  
  RESULTS
  SI did not vary during EE/DRSP (from 3.72±2.62 to 3.29±2.93; p=0.73). Similarly, values of Sg did not vary (from 0.03±0.02 to 0.032±0.014; p=0.87). An increase was observed in HDL cholesterol (9.4±9.8mg/dl; p=0.05) and triglycerides (46.9±75.1mg/dl; p=0.046), with no modification in LDL cholesterol (-4.64±1.704mg/dl; p=0.6).
  
  
  CONCLUSIONS
  EE/DRSP does not deteriorate SI. These results are reassuring for the long-term use of this association.
authors.affiliation: Department Obstetrics Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy. Electronic address: cagnacci@unimore.it.
authors.forename: Angelo
authors.initials: A
authors.lastname: Cagnacci
authors.affiliation: Department Obstetrics Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Piacenti
authors.affiliation: Department Obstetrics Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
authors.forename: Renata
authors.initials: R
authors.lastname: Zanin
authors.affiliation: Department Obstetrics Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
authors.forename: Anjeza
authors.initials: A
authors.lastname: Xholli
authors.affiliation: Department Obstetrics Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tirelli
mesh_terms: D000328:Adult; D000736:Androstenes / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
chemical_list: D000736:Androstenes; D001786:Blood Glucose; D008076:Cholesterol, HDL; D003277:Contraceptives, Oral, Combined; D007328:Insulin; D014280:Triglycerides; D004997:Ethinyl Estradiol; C035144:drospirenone
keywords: Contraception; Drospirenone; Glucose; Insulin sensitivity; Lipoprotein