title: The role of nerve growth factor and its receptors in tumorigenesis and cancer pain.
abstract: The nerve growth factor (NGF) is a growth factor that belongs to the neurotrophin family. NGF has two structurally different receptors, the p75 neurotrophin receptor (p75NTR) and the tropomyosin-related kinase A (TrkA). Interaction of NGF with its receptors regulates a variety of physiological processes of neuronal system. Recent studies have shown that NGF and its receptors were involved in the regulation of tumourigenesis by either supporting or suppressing tumor growth depending on the tumor types. This review summarizes the current views of NGF and its receptors in tumorigenesis and cancer pain.
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University.
authors.forename: Wenfang
authors.initials: W
authors.lastname: Wang
authors.forename: Jinhua
authors.initials: J
authors.lastname: Chen
authors.forename: Xiuli
authors.initials: X
authors.lastname: Guo
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D020932:Nerve Growth Factor / Q000378:metabolism*; D010146:Pain / Q000378:metabolism / Q000503:physiopathology; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D020917:Receptor, trkA / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*
chemical_list: D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D020932:Nerve Growth Factor; D020917:Receptor, trkA