title: Genome scan for cognitive trait loci of dyslexia: Rapid naming and rapid switching of letters, numbers, and colors.
abstract: Dyslexia, or specific reading disability, is a common developmental disorder that affects 5-12% of school-aged children. Dyslexia and its component phenotypes, assessed categorically or quantitatively, have complex genetic bases. The ability to rapidly name letters, numbers, and colors from rows presented visually correlates strongly with reading in multiple languages and is a valid predictor of reading and spelling impairment. Performance on measures of rapid naming and switching, RAN and RAS, is stable throughout elementary school years, with slowed performance persisting in adults who still manifest dyslexia. Targeted analyses of dyslexia candidate regions have included RAN measures, but only one other genome-wide linkage study has been reported. As part of a broad effort to identify genetic contributors to dyslexia, we performed combined oligogenic segregation and linkage analyses of measures of RAN and RAS in a family-based cohort ascertained through probands with dyslexia. We obtained strong evidence for linkage of RAN letters to the DYX3 locus on chromosome 2p and RAN colors to chromosome 10q, but were unable to confirm the chromosome 6p21 linkage detected for a composite measure of RAN colors and objects in the previous genome-wide study.
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, Washington.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Rubenstein
authors.forename: Wendy H
authors.initials: WH
authors.lastname: Raskind
authors.forename: Virginia W
authors.initials: VW
authors.lastname: Berninger
authors.forename: Mark M
authors.initials: MM
authors.lastname: Matsushita
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Wijsman
mesh_terms: D000293:Adolescent; D001499:Bayes Theorem; D002648:Child; D020090:Chromosome Segregation / Q000235:genetics; D003071:Cognition; D003116:Color; D016001:Confidence Intervals; D004410:Dyslexia / Q000235:genetics*; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006801:Humans; D007802:Language; D008433:Mathematics; D040641:Quantitative Trait Loci / Q000235:genetics*; D011932:Reading
keywords: MCMC; complex trait; general pedigrees; learning disabilities; rapid automatized naming