title: Paclitaxel-coated balloons and aneurysm formation in peripheral vessels.
abstract: We report two cases of early aneurysmal vessel dilatation after a paclitaxel-coated balloon (PCB) was used for angioplasty of the peripheral vessels. The first case refers to a failing vein bypass with a tight proximal anastomotic stenosis, whereas the second refers to a distal tibial artery occlusion. A PCB was used to treat both patients. Aneurysmal dilatation of the previously treated segment was noted in both patients during subsequent follow-up imaging. In the absence of other causal factors, we attribute both cases to PCB application. The aneurysms that formed had no detrimental effect on the patients' health and required no further treatment; however, it is important to bear in mind this potential risk of presumed paclitaxel toxicity.
authors.affiliation: Department of Interventional Radiology, Guy's and St. Thomas' NHS Trust, St. Thomas' Hospital, London, United Kingdom. Electronic address: adiamantopoulos@gmail.com.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Diamantopoulos
authors.affiliation: Department of Interventional Radiology, Guy's and St. Thomas' NHS Trust, St. Thomas' Hospital, London, United Kingdom.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Gupta
authors.affiliation: Department of Vascular Surgery, Guy's and St. Thomas' NHS Trust, St. Thomas' Hospital, London, United Kingdom.
authors.forename: Hany
authors.initials: H
authors.lastname: Zayed
authors.affiliation: Department of Vascular Surgery, Guy's and St. Thomas' NHS Trust, St. Thomas' Hospital, London, United Kingdom.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Katsanos
mesh_terms: D000369:Aged, 80 and over; D000783:Aneurysm / Q000139:chemically induced* / Q000175:diagnosis; D000800:Angioplasty, Balloon / Q000009:adverse effects* / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D020099:Coated Materials, Biocompatible; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D011859:Radiography; D012501:Saphenous Vein / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology / Q000637:transplantation*; D016909:Tibial Arteries / Q000000981:diagnostic imaging / Q000187:drug effects*; D062666:Vascular Access Devices
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible; D017239:Paclitaxel