title: Topographical binding to mucosa-exposed cancer cells: pollen-mimetic porous microspheres with tunable pore sizes.
abstract: Mucoadhesives have been perceived as an effective approach for targeting the mucosa-associated diseases, which relied on the adhesive molecules to enhance the specificity. Here, topographical binding is proposed based on the fabrication of surface pore size tunable pollen-mimetic microspheres with phase separation and electrospray technology. We proved that microspheres with large-pores (pore size of 1005 ± 448 nm) were the excellent potential candidate for the mucoadhesives, as they not only possessed better adhesion ability, but also could topographically bind cervical cancer cells. Our methods of topographical binding offered a new way of designing the mucoadhesives for treating the mucosa-associated diseases.
authors.affiliation: §National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Jiantao
authors.initials: J
authors.lastname: Feng
authors.affiliation: ⊥Engineering Research Center of Marine Biological Resource Comprehensive Utilization, The Third Institute of Oceanography of the State Oceanic Administration, Xiamen 361005, China.|#Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.affiliation: §National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Chen
authors.affiliation: §National Center for Nanoscience and Technology, Beijing 100190, China.|||First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
authors.forename: Wenda
authors.initials: W
authors.lastname: Hua
authors.affiliation: §National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Quanmei
authors.initials: Q
authors.lastname: Sun
authors.affiliation: §National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Ao
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
authors.affiliation: #Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.affiliation: #Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Shutao
authors.initials: S
authors.lastname: Wang
authors.affiliation: §National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Han
mesh_terms: D000268:Adhesiveness; D000269:Adhesives / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D008422:Materials Testing; D008863:Microspheres; D009092:Mucous Membrane / Q000737:chemistry*; D011058:Pollen / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D002583:Uterine Cervical Neoplasms / Q000737:chemistry*
chemical_list: D000269:Adhesives
keywords: adhesive; cancer cell; microsphere; mucosa; topographical binding