title: [Peculiarities and clinical significance of drug pharmacokinetics and pharmacodynamics during pregnancy].
abstract: There are relatively few data reported on specific features of drug pharmacokinetics (PK) and pharmacodynamics in pregnancy compared to the non-pregnant state. Changes in maternal physiology and metabolic processes during pregnancy effect on PK and show that standard adult dosing is likely to be incorrect during pregnancy. Physiology-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and to correctly predict drug exposure and response on the personal level.
authors.forename: O V
authors.initials: OV
authors.lastname: Reshet'ko
authors.forename: K A
authors.initials: KA
authors.lastname: Lutsevich
authors.forename: I I
authors.initials: II
authors.lastname: Sanina
mesh_terms: D000998:Antiviral Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D001682:Biological Availability; D001711:Biotransformation; D001798:Blood Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D004334:Drug Administration Schedule; D054796:Drug Dosage Calculations; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D007251:Influenza, Human / Q000097:blood* / Q000188:drug therapy* / Q000821:virology; D015233:Models, Statistical; D053139:Oseltamivir / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D011247:Pregnancy; D011485:Protein Binding
chemical_list: D000998:Antiviral Agents; D001798:Blood Proteins; D002352:Carrier Proteins; D053139:Oseltamivir