title: Rhodium(III)-catalyzed C2-selective carbenoid functionalization and subsequent C7-alkenylation of indoles.
abstract: Here a new, mild and versatile method for efficient synthesis of a diverse range of 2-acetate substituted indoles via Rh(III)-catalyzed and alcohol-mediated C2-selective carbenoid insertion functionalization of indoles by α-diazotized Meldrum's acid has been developed. Furthermore, for the first time, a Rh(III)/Cu(II)-catalyzed direct C7-alkenylation of such functionalized products has also been demonstrated.
authors.affiliation: VARI/SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China. yiwei.simm@simm.ac.cn eric.xu@simm.ac.cn.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Shi
authors.forename: Yunnan
authors.initials: Y
authors.lastname: Yan
authors.forename: Qiu
authors.initials: Q
authors.lastname: Li
authors.forename: H Eric
authors.initials: HE
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Yi
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D004146:Dioxanes; D007211:Indoles; D003300:Copper; C076489:Meldrum's acid; D012238:Rhodium