title: Synthesis and insecticidal activity of novel hydrazone compounds derived from a naturally occurring lignan podophyllotoxin against Mythimna separata (Walker).
abstract: In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, a series of novel hydrazone derivatives of podophyllotoxin, which is a naturally occurring aryltetralin lignan and isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum species, were synthesized and evaluated as insecticidal agents against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1mg/mL. Especially compounds 8i, 8j, 8t, and 8u showed the more potent insecticidal activity with the final mortality rates greater than 60%.
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China; College of Agriculture, Shanxi Agriculture University, Taigu 030801, Shanxi Province, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China. Electronic address: orgxuhui@nwsuaf.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006835:Hydrazones / Q000138:chemical synthesis; D007306:Insecticides / Q000138:chemical synthesis; D007814:Larva; D017705:Lignans / Q000737:chemistry; D008958:Models, Molecular; D009036:Moths; D018517:Plant Roots / Q000737:chemistry; D011034:Podophyllotoxin / Q000031:analogs & derivatives*
chemical_list: D006835:Hydrazones; D007306:Insecticides; D017705:Lignans; D011034:Podophyllotoxin
keywords: Botanical insecticide; Insecticidal activity; Mythimna separata Walker; Podophyllotoxin; Structural modification