title: Amphiphilic polyvinyl alcohol adsorbent for the removal of low-density lipoprotein.
abstract: Spacer can effectively reduce the steric hindrance and synergistic effect of the hydrophilic and hydrophobic ligands immobilized in adsorbents can improve the specific adsorption for low-density lipoprotein (LDL). In this paper, in order to improve the adsorption capacity for the Low-density lipoprotein-cholesterol (LDL-C), specifically, amphiphilic adsorbent based on polyvinyl alcohol (PVA) containing cholesterol ligand and sulfonic dextran ligands was synthesized. All kinds of factors affecting the synthesis yield and adsorption properties were studied in detail. Results showed that the amphiphilic PVA adsorbent has higher adsorption capacity for total cholesterol (TC), (LDL-C), triglyceride (TG), and lower adsorption capacity, and percentage for high-density lipoprotein-cholesterol (HDL-C), while the ligand ratio of cholesterol to sulfonic ligands is 1.57:1, the adsorption percentage and adsorption capacity for TC, LDL-C, TG, and HDL-C were 54.4%, 67.6%, 42.5%, 10.4% and 4.02, 3.612, 2.154, 0.168 mg/g, respectively.
authors.affiliation: The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University , Tianjin , P. R. China.
authors.forename: Yao Ting
authors.initials: YT
authors.lastname: Yu
authors.forename: Huijun
authors.initials: H
authors.lastname: Zhu
authors.forename: Shenqi
authors.initials: S
authors.lastname: Wang
mesh_terms: D000327:Adsorption; D002784:Cholesterol / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004355:Drug Stability; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D017953:Isocyanates / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry* / Q000302:isolation & purification; D011142:Polyvinyl Alcohol / Q000138:chemical synthesis / Q000737:chemistry*; D019802:Succinic Acid / Q000737:chemistry
chemical_list: D003911:Dextrans; D017953:Isocyanates; D008024:Ligands; D008077:Lipoproteins, LDL; C015262:1,6-hexamethylene diisocyanate; D011142:Polyvinyl Alcohol; D002784:Cholesterol; D019802:Succinic Acid
keywords: PVA; adsorption property; amphiphilic; low density lipoprotein-cholesterol