title: Apolipoprotein B as an independent predictor of arterial stiffness in systemic lupus erythematosus patients.
abstract: OBJECTIVE
  To determine the relationship of apolipoprotein B (Apo-B) and arterial stiffness determined by brachial-ankle pulse wave velocity (baPWV) in systemic lupus erythematosus (SLE) subjects.
  
  
  METHODS
  Eighty-seven Thai SLE subjects with inactive disease activity were studied. Fasting blood was collected for creatinine, glucose, lipid profiles, Apo-B and Apo-A1. Pearson correlation and stepwise-linear regression were used for the analysis.
  
  
  RESULTS
  The mean age of the subjects was 36.69 ± 10.85 years; 6.90% of them had stage 3 or more severe chronic kidney disease, 49.40% took anti-hypertensive drugs and 4.60% had abnormal glucose metabolism. The mean value for baPWV was 1332 ± 274.12 cm/s. Thirty-six percent of the subjects had increased arterial stiffness with mean Apo-B levels of 1.05 ± 0.31 g/L compared to 0.94 ± 0.24 in normal arterial stiffness. There were correlations of baPWV with age, systolic blood pressure (BP), diastolic BP and creatinine clearance. Apo-B tended to be associated with baPWV (P = 0.06) whereas low-density lipoprotein cholesterol did not (P = 0.2). By multiple regression analysis, systolic BP, age and Apo-B were the significant predictors of baPWV.
  
  
  CONCLUSIONS
  Apo-B was independently associated with arterial stiffness in SLE subjects.
authors.affiliation: Divisions of Endocrinology and Metabolism, Department of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Jirateep
authors.initials: J
authors.lastname: Kwankaew
authors.affiliation: Divisions of Endocrinology and Metabolism, Department of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Rattana
authors.initials: R
authors.lastname: Leelawattana
authors.affiliation: Division of Rheumatology, Department of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Anchalee
authors.initials: A
authors.lastname: Saignam
authors.affiliation: Division of Rheumatology, Department of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Boonjing
authors.initials: B
authors.lastname: Siripaitoon
authors.affiliation: Division of Rheumatology, Department of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Parichat
authors.initials: P
authors.lastname: Uea-Areewongsa
authors.affiliation: Division of Rheumatology, Department of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Siriporn
authors.initials: S
authors.lastname: Juthong
mesh_terms: D000328:Adult; D017677:Age Distribution; D000704:Analysis of Variance; D055109:Ankle Brachial Index; D001055:Apolipoproteins B / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011673:Pulsatile Flow; D012720:Severity of Illness Index; D017678:Sex Distribution; D013785:Thailand; D059289:Vascular Stiffness
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers
keywords: apolipoprotein-B; arterial stiffness; brachial-ankle pulse wave velocity; lipid profile; systemic lupus erythematosus