title: Does the microbiome play a causal role in spondyloarthritis?
abstract: The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.
authors.affiliation: Division of Arthritis and Rheumatic Diseases and Department of Ophthalmology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd. L467Ad, Portland, OR, 97239, USA, rosenbaj@ohsu.edu.
authors.forename: James T
authors.initials: JT
authors.lastname: Rosenbaum
authors.forename: Phoebe
authors.initials: P
authors.lastname: Lin
authors.forename: Mark
authors.initials: M
authors.lastname: Asquith
authors.forename: Mary-Ellen
authors.initials: ME
authors.lastname: Costello
authors.forename: Tony J
authors.initials: TJ
authors.lastname: Kenna
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Brown
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D015796:HLA-B27 Antigen / Q000502:physiology; D006801:Humans; D007107:Immune System; D015212:Inflammatory Bowel Diseases / Q000382:microbiology; D007592:Joint Diseases / Q000382:microbiology; D064307:Microbiota; D051381:Rats; D025241:Spondylarthritis / Q000150:complications / Q000382:microbiology*
chemical_list: D015796:HLA-B27 Antigen