title: Deregulation of bone forming cells in bone diseases and anabolic effects of strontium-containing agents and biomaterials.
abstract: Age-related bone loss and osteoporosis are associated with bone remodeling changes that are featured with decreased trabecular and periosteal bone formation relative to bone resorption. Current anticatabolic therapies focusing on the inhibition of bone resorption may not be sufficient in the prevention or reversal of age-related bone deterioration and there is a big need in promoting osteoblastogenesis and bone formation. Enhanced understanding of the network formed by key signaling pathways and molecules regulating bone forming cells in health and diseases has therefore become highly significant. The successful development of agonist/antagonist of the PTH and Wnt signaling pathways are profits of the understanding of these key pathways. As the core component of an approved antiosteoporosis agent, strontium takes its effect on osteoblasts at multilevel through multiple pathways, representing a good example in revealing and exploring anabolic mechanisms. The recognition of strontium effects on bone has led to its expected application in a variety of biomaterial scaffolds used in tissue engineering strategies aiming at bone repairing and regeneration. While summarizing the recent progress in these respects, this review also proposes the new approaches such as systems biology in order to reveal new insights in the pathology of osteoporosis as well as possible discovery of new therapies.
authors.affiliation: Key State Laboratory for Biotherapy, Sichuan University, Chengdu 610065, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Tan
authors.affiliation: Anti-Ageing and Regenerative Medicine Centre, Shenzhen University, 3688 Nanhai Avenue, Shenzhen, Guangdong 518060, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Institute for Systems Biomedicine, Shanghai Jiaotong University, Shanghai 200240, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Institute for Systems Biomedicine, Shanghai Jiaotong University, Shanghai 200240, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ao
authors.affiliation: Anti-Ageing and Regenerative Medicine Centre, Shenzhen University, 3688 Nanhai Avenue, Shenzhen, Guangdong 518060, China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Spinal Surgery, Nanshan People's Hospital, Shenzhen 518000, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Yi
authors.affiliation: Key State Laboratory for Biotherapy, Sichuan University, Chengdu 610065, China ; Anti-Ageing and Regenerative Medicine Centre, Shenzhen University, 3688 Nanhai Avenue, Shenzhen, Guangdong 518060, China.
authors.forename: Guang-Qian
authors.initials: GQ
authors.lastname: Zhou
mesh_terms: D045930:Anabolic Agents; D000818:Animals; D001672:Biocompatible Materials; D016723:Bone Remodeling; D006801:Humans; D051379:Mice; D010006:Osteoblasts; D010012:Osteogenesis; D010024:Osteoporosis; D013324:Strontium; D060449:Wnt Signaling Pathway
chemical_list: D045930:Anabolic Agents; D001672:Biocompatible Materials; D013324:Strontium