title: Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3.
abstract: Pemphigus vulgaris (PV) is an autoimmune skin disease, which has been characterized by IgG autoantibodies to desmoglein 3. Here we studied the antibody signatures of PV patients compared with healthy subjects and with patients with two other autoimmune diseases with skin manifestations (systemic lupus erythematosus and scleroderma), using an antigen microarray and informatics analysis. We now report a previously unobserved phenomenon--patients with PV, compared with the healthy subjects and the two other diseases, show a significant decrease in IgG autoantibodies to a specific set of self-antigens. This novel finding demonstrates that an autoimmune disease may be associated with a loss of specific, healthy IgG autoantibodies and not only with a gain of specific, pathogenic IgG autoantibodies.
authors.affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel; Department of Nephrology, Rabin Medical Centre, Petach Tikva, Israel.
authors.forename: Ittai
authors.initials: I
authors.lastname: Fattal
authors.forename: Jacob
authors.initials: J
authors.lastname: Rimer
authors.forename: Noam
authors.initials: N
authors.lastname: Shental
authors.forename: Yair
authors.initials: Y
authors.lastname: Molad
authors.forename: Armando
authors.initials: A
authors.lastname: Gabrielli
authors.forename: Avi
authors.initials: A
authors.lastname: Livneh
authors.forename: Ofer
authors.initials: O
authors.lastname: Sarig
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldberg
authors.forename: Uzi
authors.initials: U
authors.lastname: Gafter
authors.forename: Eytan
authors.initials: E
authors.lastname: Domany
authors.forename: Irun R
authors.initials: IR
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D016022:Case-Control Studies; D051184:Desmoglein 3 / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D051184:Desmoglein 3; D007074:Immunoglobulin G
keywords: autoantibodies; pemphigus vulgaris; scleroderma; systemic lupus erythematosus