title: Therapeutic potential of microRNA: a new target to treat intrahepatic portal hypertension?
abstract: Intrahepatic portal hypertension accounts for most of the morbidity and mortality encountered in patients with liver cirrhosis, due to increased portal inflow and intrahepatic vascular resistance. Most treatments have focused only on portal inflow or vascular resistance. However, miRNA multitarget regulation therapy may potentially intervene in these two processes for therapeutic benefit in cirrhosis and portal hypertension. This review presents an overview of the most recent knowledge of and future possibilities for the use of miRNA therapy. The benefits of this therapeutic modality--which is poorly applied in the clinical setting--are still uncertain. Increasing the knowledge and current understanding of the roles of miRNAs in the development of intrahepatic portal hypertension and hepatic stellate cells (HSCs) functions, as well as their potential as novel drug targets, is critical.
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Can-Jie
authors.initials: CJ
authors.lastname: Guo
authors.affiliation: Digestive Disease Laboratory, Department of Gastroenterology, School of Medicine, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Pan
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Qiao
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Zhao-Lian
authors.initials: ZL
authors.lastname: Bian
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Li
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shen
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hua
authors.affiliation: Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D055166:Hepatic Stellate Cells / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000627:therapeutic use*; D017082:Portal Pressure; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs