title: Neurotrophic factors for retinal ganglion cell neuropathy - with a special reference to diabetic neuropathy in the retina.
abstract: Diabetes mellitus is a disease with a devastating impact on population. Recent data revealed that early retinal neuropathy in patients with diabetic retinopathy involved a reduced expression of brain-derived neurotrophic factor. Retinal ganglion cells (RGC) neuropathy is a progressive optic nerve neuropathy with RGC death and axonal degeneration, and it leads to blindness in the elderly population worldwide. Thus, neuroprotective therapies that rescue damaged RGCs and inhibit the progression of RGC loss and axonal degeneration are needed. This review introduces potential neuroprotective therapies using different neurotrophic factors for damaged RGC in eyes with RGC neuropathy associated diseases.
authors.forename: Guzel
authors.initials: G
authors.lastname: Bikbova
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshitari
authors.forename: Takayuki
authors.initials: T
authors.lastname: Baba
authors.affiliation: Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Chiba, Japan. Tarii@aol.com.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D001766:Blindness / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000473:pathology*; D051098:Glial Cell Line-Derived Neurotrophic Factors / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D012160:Retina / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000473:pathology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D051098:Glial Cell Line-Derived Neurotrophic Factors; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; C579455:BDNF protein, human