title: Simultaneous chromatographic analysis of photoinitiators and amine synergists in food contact materials.
abstract: Photoinitiators (PIs) are components of UV-cured inks widely used in printing of food packaging. These substances can migrate into food and may be a hazard to human health. High-performance liquid chromatography with diode-array detection (HPLC-DAD) has been used for analysis of PIs and amine synergists in food packaging. Analysis was performed with a Kromasil C18 column (250 mm × 3.2 mm i.d., 5 μm particle size) with a binary mobile phase gradient prepared from acetonitrile and Milli-Q water. The flow rate was 0.5 mL min(-1). The method enables separation of fourteen PIs and amine synergists in a single run. The method was validated for linearity, repeatability, and limits of detection and quantification. Excellent sensitivity (LODs ≤ 1.56 μg dm(2)) and appropriate repeatability (RSD (n = 10) <0.9%) were achieved. Different types of food packaging material including plastic films, cardboard, and cans were analyzed and PIs were detected in 47% of the samples tested (n = 17). Positive samples were confirmed by use of LC-MS-MS in positive electrospray ionization (ESI) mode.
authors.affiliation: Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Lago
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Bernaldo de Quirós
authors.forename: R
authors.initials: R
authors.lastname: Sendón
authors.forename: J
authors.initials: J
authors.lastname: Bustos
authors.forename: M I
authors.initials: MI
authors.lastname: Santillana
authors.forename: P
authors.initials: P
authors.lastname: Paseiro
mesh_terms: D000588:Amines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging / Q000295:instrumentation*; D017319:Photosensitizing Agents / Q000032:analysis*; D010969:Plastics / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D000588:Amines; D017319:Photosensitizing Agents; D010969:Plastics