title: Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation: Propacetamol versus Lidocaine-A Randomized Clinical Trial.
abstract: The purpose of this study is to assess the effects of propacetamol on attenuating hemodynamic responses subsequent laryngoscopy and tracheal intubation compared to lidocaine. In this randomized clinical trial, 62 patients with the American Anesthesiologists Society (ASA) class I/II who required laryngoscopy and tracheal intubation for elective surgery were assigned to receive propacetamol 2 g/I.V./infusion (group P) or lidocaine 1.5 mg/kg (group L) prior to laryngoscopy. Systolic and diastolic blood pressures (SBP, DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded at baseline, before laryngoscopy and within nine minutes after intubation. In both groups P and L, MAP increased after laryngoscopy and the changes were statistically significant (P < 0.001). There were significant changes of HR in both groups after intubation (P < 0.02), but the trend of changes was different between two groups (P < 0.001). In group L, HR increased after intubation and its change was statistically significant within 9 minutes after intubation (P < 0.001), while in group P, HR remained stable after intubation (P = 0.8). Propacetamol 2 gr one hour prior intubation attenuates heart rate responses after laryngoscopy but is not effective to prevent acute alterations in blood pressure after intubation.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, IL 60612, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Kord Valeshabad
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Nabavian
authors.affiliation: Department of Epidemiology of Biostatistics, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Keramat
authors.initials: K
authors.lastname: Nourijelyani
authors.affiliation: Department of Dermatology, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Kord
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Vafainejad
authors.affiliation: Zainaldin Martyr Research Center, Gorgan University of Agricultural Sciences and Natural Resources, P.O. Box 15739-49138, Gorgan, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Kord Valeshabad
authors.affiliation: Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott Avenue, Chicago, IL 60612, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Reza Feili
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rezaei
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Darabi
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Koohkan
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Poorya
authors.initials: P
authors.lastname: Golbinimofrad
authors.affiliation: Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.
authors.forename: Samira
authors.initials: S
authors.lastname: Jafari