title: Anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) relation with extra-articular manifestations in rheumatoid arthritis.
abstract: We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There was no association of anti-CCP and anti-MCV levels with the presence of ExRA as total group (P = 0.40 and P = 0.91, resp.). Making an analysis of individual manifestations, rheumatoid nodules were associated with positivity for rheumatoid factor (RF); (P = 0.01), anti-CCP (P = 0.048), and anti-MCV (P = 0.02). Instead, RF, anti-CCP, or anti-MCV were not associated with SS, chronic anemia, or peripheral neuropathy. Levels of anti-CCP correlated with the score of the Health Assessment Questionnaire-Disability Index (HAQ-Di) (r = 0.154, P = 0.03), erythrocyte sedimentation rate (ESR); (r = 0.155, P = 0.03), and RF (P = 0.254, P < 0.001), whereas anti-MCV titres only correlated with RF (r = 0.169, P = 0.02). On adjusted analysis, ExRA was associated with longer age (P = 0.015), longer disease duration (P = 0.007), higher DAS-28 score (P = 0.002), and higher HAQ-DI score (P = 0.007), but serum levels of anti-CCP and anti-MCV were not associated. These findings show the need to strengthen the evaluation of the pathogenic mechanisms implied in each specific ExRA manifestation.
authors.affiliation: Department of Internal Medicine-Rheumatology, Hospital General Regional 110, IMSS, Avenida Salto del Agua 2192, Colonia Jardines del Country, 44710 Guadalajara, Jal, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: Gonzalez-Lopez
authors.affiliation: Postdoctoral Program of the National Council of Science and Technology (CONACYT), 03940 Mexico City DF, Mexico.
authors.forename: Alberto Daniel
authors.initials: AD
authors.lastname: Rocha-Muñoz
authors.affiliation: Department of Internal Medicine-Rheumatology, Hospital General Regional 110, IMSS, Avenida Salto del Agua 2192, Colonia Jardines del Country, 44710 Guadalajara, Jal, Mexico ; Postgraduate Programs of Pharmacology and Public Health Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, 44340 Guadalajara, Jal, Mexico.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ponce-Guarneros
authors.affiliation: Clinical epidemiology Research Unit, UMAE, Specialties Hospital, Western Medical Center, Mexican Institute for Social Security (IMSS), 44340 Guadalajara, Jal, Mexico.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Flores-Chavez
authors.affiliation: Physiology Department, CUCS, University of Guadalajara Research Division, UMAE, CMNO, IMSS, 44340 Guadalajara, Jal, Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Paramo
authors.affiliation: Clinical epidemiology Research Unit, UMAE, Specialties Hospital, Western Medical Center, Mexican Institute for Social Security (IMSS), 44340 Guadalajara, Jal, Mexico.
authors.forename: Arnulfo
authors.identifier: 0000-0003-3061-521X
authors.initials: A
authors.lastname: Nava
authors.affiliation: Department of Physiology, CUCS, University of Guadalajara, 44340 Guadalajara, Jal, Mexico.
authors.forename: Ernesto German
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.affiliation: Clinical epidemiology Research Unit, UMAE, Specialties Hospital, Western Medical Center, Mexican Institute for Social Security (IMSS), 44340 Guadalajara, Jal, Mexico.
authors.forename: Nicte Selene
authors.initials: NS
authors.lastname: Fajardo-Robledo
authors.affiliation: Postgraduate Program of Biomedical Sciences (Immunology), CUCS, University of Guadalajara, 44340 Guadalajara, Jal, Mexico.
authors.forename: Soraya Amali
authors.initials: SA
authors.lastname: Zavaleta-Muñiz
authors.affiliation: Postgraduate Programs of Pharmacology and Public Health Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, 44340 Guadalajara, Jal, Mexico.
authors.forename: Teresa
authors.initials: T
authors.lastname: Garcia-Cobian
authors.affiliation: Clinical epidemiology Research Unit, UMAE, Specialties Hospital, Western Medical Center, Mexican Institute for Social Security (IMSS), 44340 Guadalajara, Jal, Mexico.
authors.forename: Jorge Ivan
authors.initials: JI
authors.lastname: Gamez-Nava
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012307:Risk Factors; D012720:Severity of Illness Index; D014746:Vimentin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; D014746:Vimentin; C487763:cyclic citrullinated peptide