title: [Emerging notions about the microenvironmental control of tumor growth and dissemination].
abstract: In spite of a good understanding of the cellular and molecular mechanisms responsible for neoplastic transformation, most cancer therapies remain partially effective and transient. Recent studies established the importance of the tumor microenvironment in tumor growth and dissemination, and in the resistance to antitumor therapies. This review summarizes our current knowledge of the local and systemic effects, sometimes surprising, which result from interactions between neoplastic cancer cells and their microenvironment.
authors.affiliation: UMR 1132, université Paris Diderot, centre Viggo Petersen-hôpital Lariboisière, 2, rue Ambroise Paré, 75010 Paris, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Provot
mesh_terms: D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured; D059016:Tumor Microenvironment