title: Relationship between angiotensin-converting enzyme gene polymorphism and respiratory distress syndrome in premature neonates.
abstract: OBJECTIVE
  The aim of this study was to investigate the possible relationship between angiotensin-converting enzyme (ACE) gene polymorphism (D/D and I/D genotypes) and respiratory distress syndrome (RDS) in preterm neonates.
  
  
  METHODS
  Our study included 120 preterm neonates (<37 weeks of gestation) with RDS (the patient group) and 120 preterm neonates without RDS (the control group). Blood samples were obtained from patients and control groups, and ACE gene polymorphism was analysed using the polymerase chain reaction method.
  
  
  RESULTS
  D/D genotype was highly significant in the patient group compared with the control group (48.3% of RDS group vs 20% of the control group, P < 0.001). Meanwhile, I/D and I/I genotypes were significantly higher in the control group (75% and 5% of the control group vs 50% and 1.7% of the patient group, P < 0.001). D/D genotype was highly significant in neonates with bronchopulmonary dysplasia (BPD) compared with I/D genotype (P = 0.001).
  
  
  CONCLUSIONS
  Our results may suggest that D/D genotype is associated with increased risk of RDS and BPD development in preterm neonates.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Nouran Fahmy
authors.initials: NF
authors.lastname: Hussein
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Eman Abdel Ghany
authors.initials: EA
authors.lastname: Abdel Ghany
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Walaa Alsharany
authors.initials: WA
authors.lastname: Abu Elhamed
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Rania Mohamed
authors.initials: RM
authors.lastname: Samy
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012127:Respiratory Distress Syndrome, Newborn / Q000201:enzymology / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: ACE gene polymorphism; bronchopulmonary dysplasia; preterm infant; respiratory distress syndrome