title: Pulmonary drug delivery by powder aerosols.
abstract: The efficacy of pharmaceutical aerosols relates to its deposition in the clinically relevant regions of the lungs, which can be assessed by in vivo lung deposition studies. Dry powder formulations are popular as devices are portable and aerosolisation does not require a propellant. Over the years, key advancements in dry powder formulation, device design and our understanding on the mechanics of inhaled pharmaceutical aerosol have opened up new opportunities in treatment of diseases through pulmonary drug delivery. This review covers these advancements and future directions for inhaled dry powder aerosols.
authors.affiliation: Advanced Drug Delivery Group, Faculty of Pharmacy (A15), University of Sydney, Sydney, NSW 2006, Australia. Electronic address: yifei.yang@sydney.edu.au.
authors.forename: Michael Yifei
authors.initials: MY
authors.lastname: Yang
authors.affiliation: Advanced Drug Delivery Group, Faculty of Pharmacy (A15), University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jcha5503@uni.sydney.edu.au.
authors.forename: John Gar Yan
authors.initials: JG
authors.lastname: Chan
authors.affiliation: Advanced Drug Delivery Group, Faculty of Pharmacy (A15), University of Sydney, Sydney, NSW 2006, Australia. Electronic address: kim.chan@sydney.edu.au.
authors.forename: Hak-Kim
authors.initials: HK
authors.lastname: Chan
mesh_terms: D000336:Aerosols; D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D058995:Dry Powder Inhalers; D004867:Equipment Design; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D011208:Powders; D055672:Static Electricity; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D000336:Aerosols; D007328:Insulin; D004364:Pharmaceutical Preparations; D011208:Powders
keywords: Dry powder formulation; Dry powder inhaler; Lung deposition; Pharmaceutical aerosol; Pulmonary drug delivery; SPECT imaging