title: Dose per unit cumulated activity (S-values) for e⁻ and beta emitting radionuclides in cancer cell models calculated by Monte Carlo simulation.
abstract: Cell dosimetry is relevant regarding new efforts in specific molecular radiotherapy using Auger, CE and beta emitters. Absorbed dose in cells can be obtained by means of the dose per unit cumulated activity (S-values), together with the activity distribution. In this work, Monte Carlo simulation codes PENELOPE and MCNPX were used to obtain cellular S-values for point and extended sources of electrons and beta emitting radionuclides in the nucleus of breast (MDA-MB231, MCF7) and prostate (PC3) cancer cell models.
authors.affiliation: Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac, Estado de México, México. Electronic address: leticia.rojas@inin.gob.mx.
authors.forename: E L
authors.initials: EL
authors.lastname: Rojas-Calderón
authors.affiliation: Universidad Autónoma del Estado de México, Paseo Tollocan S/N esquina Jesús Carranza, Colonia Moderna de la Cruz, 50180 Toluca, Estado de México, México.
authors.forename: E
authors.initials: E
authors.lastname: Torres-García
authors.affiliation: Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac, Estado de México, México.
authors.forename: O
authors.initials: O
authors.lastname: Ávila
mesh_terms: D065638:Absorption, Radiation; D001610:Beta Particles; D045744:Cell Line, Tumor; D003198:Computer Simulation; D004583:Electrons; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D009374:Neoplasms, Experimental / Q000503:physiopathology* / Q000532:radiotherapy*; D011868:Radioisotopes / Q000032:analysis* / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness
chemical_list: D011868:Radioisotopes
keywords: Cancer cells; Dose; Molecular radiotherapy; Monte Carlo; Radionuclides; S-values