title: Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice.
abstract: BACKGROUND
  Although sarcoidosis is a well-known disease, sarcoidosis patient outcome and the role of prognostic markers in everyday practice have not yet been well described. Therefore, the goal of the present study was to analyse the fate of sarcoidosis patients and the factors influencing the disease's behaviour in routine practice.
  
  
  METHODS
  The study was a retrospective analysis of 306 consecutive patients (181 females and 125 males; median age 45 years) diagnosed with sarcoidosis in the years 2003-2012.
  
  
  RESULTS
  Through the use of uniparametric analysis, it was determined that the stage of the disease, organ involvement, CD4/CD8 ratio in the bronchoalveolar lavage fluid (BALF), serum and urine calcium levels, smoking, and pulmonary functions had a significant influence on spontaneous sarcoidosis resolution. Multiparametric analysis revealed that spontaneous resolution was significantly positively influenced by female gender, a less advanced disease stage, a higher CD4/CD8 ratio in the BALF, lymphocytosis in the BALF and normal pulmonary functions at diagnosis. During follow-up, only three patients died. The causes of death were respiratory failure with pneumonia (n = 2) and heart attack caused by sarcoidosis heart involvement (n = 1).
  
  
  CONCLUSIONS
  The data show sarcoidosis as a disorder with high variability in clinical and laboratory findings but with good general prognosis.
authors.affiliation: Department of Pneumology and Phtiseology, Faculty of Medicine and University Hospital, Brno, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Doubková
authors.affiliation: Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Brno, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Pospíšil
authors.affiliation: Department of Pneumology and Phtiseology, Faculty of Medicine and University Hospital, Brno, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Skřičková
authors.affiliation: Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
authors.forename: Michael
authors.initials: M
authors.lastname: Doubek
mesh_terms: D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D012737:Sex Factors; D055815:Young Adult
keywords: diagnosis; prognostic factors; sarcoidosis; therapy