title: Evidence-Based Recommendations for Fertility Preservation Options for Inclusion in Treatment Protocols for Pediatric and Adolescent Patients Diagnosed With Cancer.
abstract: As survival rates improve for pediatric cancers, increased attention has been paid to late effects of cancer therapy, in particular, infertility. Fertility preservation options are available for pre- and postpubertal cancer patients; however, many providers lack knowledge regarding options. The aim of this article is to provide a comprehensive synthesis of current evidence and recommendations regarding fertility preservation options for children, adolescents, and young adults undergoing cancer treatment. A systematic search was performed to identify fertility preservation evidence. Fifty-three studies and 4 clinical guidelines were used for the review. Final recommendations consisted of 2 strong and 1 weak recommendation for both female and male fertility preservation options. The treatment team should be knowledgeable about fertility preservation so that they can educate patients and families about available fertility preservation options. It is important to consider and discuss all available fertility options with patients at the time of diagnosis.
authors.affiliation: Columbia University Medical Center, New York, NY, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Fernbach
authors.affiliation: Ann & Robert H. Lurie Children's Hospital, Chicago, IL, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Lockart
authors.affiliation: MACC Fund Center for Cancer and Blood Disorders, Milwaukee, WI, USA.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Armus
authors.affiliation: Life After Cancer Program, Cook Children's Medical Center, Fort Worth, TX, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bashore
authors.affiliation: Columbia University Medical Center, New York, NY, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Levine
authors.affiliation: Seattle Children's Hospital, Seattle, WA, USA.
authors.forename: Leah
authors.initials: L
authors.lastname: Kroon
authors.affiliation: Children's Hospital Colorado, Aurora, CO, USA.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Sylvain
authors.affiliation: Duke University School of Nursing, Durham, NC, USA cheryl.rodgers@duke.edu.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Rodgers
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002985:Clinical Protocols; D055318:Evidence-Based Nursing; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007246:Infertility / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000451:nursing; D009736:Nursing Process / Q000592:standards*
chemical_list: D000970:Antineoplastic Agents
keywords: adolescent; cancer treatment; fertility preservation; pediatric; young adult