title: Ultrasensitive flow sensing of a single cell using graphene-based optical sensors.
abstract: On the basis of the polarization-dependent absorption of graphene under total internal reflection, we designed a graphene-based optical refractive index sensor with high resolution of 1.7 × 10(-8) and sensitivity of 4.3 × 10(7) mV/RIU, as well as an extensive dynamic range. This highly sensitive graphene optical sensor enables label-free, live-cell, and highly accurate detection of a small quantity of cancer cells among normal cells at the single-cell level and the simultaneous detection and distinction of two cell lines without separation. It provides an accurate statistical distribution of normal and cancer cells with fewer cells. This facile and highly sensitive sensing refractive index may expand the practical applications of the biosensor.
authors.affiliation: The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Teda Applied Physics School and School of Physics, Nankai University , Tianjin 300457, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xing
authors.forename: Gui-Xian
authors.initials: GX
authors.lastname: Meng
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lei-Ting
authors.initials: LT
authors.lastname: Pan
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Zhi-Bo
authors.initials: ZB
authors.lastname: Liu
authors.forename: Wen-Shuai
authors.initials: WS
authors.lastname: Jiang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chen
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Tian