title: The role of tissue factor isoforms in cancer biology.
abstract: Tissue Factor (TF) is an evolutionary conserved glycoprotein, which is of immense importance for a variety of biologic processes. TF is expressed in two naturally occurring protein isoforms, membrane-bound "full-length" (fl)TF and soluble alternatively spliced (as)TF. The TF isoform expression is differentially modulated on post-transcriptional level via regulatory factors, such as serine/arginine-rich (SR) proteins, SR protein kinases and micro (mi)RNAs. Both isoforms mediate a variety of physiologic- and pathophysiologic-relevant functions, such as thrombogenicity, angiogenesis, cell signaling, tumor cell proliferation and metastasis. In this review, we will depict the main mechanisms regulating the TF isoform expression in cancer and under other pathophysiologic-relevant conditions. Moreover, we will summarize and discuss the latest findings regarding the role of TF and its isoforms in cancer biology.
authors.affiliation: Charité - Universitätsmedizin Berlin, Campus Mitte, Charite Centrum 04/13, Berlin, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Leppert
authors.affiliation: Charité - Universitätsmedizin Berlin, Campus Mitte, Charite Centrum 04/13, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Eisenreich
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic; D020033:Protein Isoforms; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D015398:Signal Transduction; D013925:Thromboplastin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D013925:Thromboplastin
keywords: alternative splicing; angiogenesis; cancer biology; lung cancer; thrombogenicity; tissue factor; tumorigenesis