title: Negative pigment network and shiny white streaks: a dermoscopic-pathological correlation study.
abstract: It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by the presence of NPN and/or SWS, including histopathologically confirmed dermatofibroma (2), Spitz nevus (3), compound nevus (6), dysplastic nevus (7), and melanoma (7), were evaluated for the presence of NPN, SWS, and blue-white veil. The histopathologic features such as orthokeratosis, orthokeratosis plus nests of pigmented melanocytes at the junction, hypergranulosis, hypergranulosis plus nests of pigmented melanocytes at the junction, epidermal invagination plus orthokeratosis, fibrosis, lamellar fibrosis, and elongation and bridging of rete ridges were evaluated. We found a disagreement in 80% of skin lesions between NPN and fibrosis (P = 0.02). For SWS, a significant agreement emerged with hypergranulosis (76%; P = 0.01), and the same occurred with fibrosis (80%; P = 0.01). Moreover, blue-white veil also displayed a significant agreement with hypergranulosis (68%; P = 0.04). Our findings confirm the correlation of SWS with fibrosis, whereas a clear-cut histopathologic substrate of NPN could not be established.
authors.affiliation: *Division of Medical Oncology C, Preventive Oncology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy; †Division of Pathology, Centro di Riferimento Oncologico, National Cancer institute, Aviano, Italy; ‡Dermatology Research Centre, the University of Queensland, School of Medicine, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia; §Department of Dermatology, University of Siena, Siena, Italy; and ¶Department of Dermatology, Medical University of Graz, Graz, Austria.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Pizzichetta
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Canzonieri
authors.forename: Peter H
authors.initials: PH
authors.lastname: Soyer
authors.forename: Pietro
authors.initials: P
authors.lastname: Rubegni
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Cesare
authors.initials: C
authors.lastname: Massone
mesh_terms: D000328:Adult; D000368:Aged; D046169:Dermoscopy; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D055815:Young Adult