title: Age-related iron deposition in the basal ganglia of controls and Alzheimer disease patients quantified using susceptibility weighted imaging.
abstract: This study aimed to investigate age-related iron deposition changes in healthy subjects and Alzheimer disease patients using susceptibility weighted imaging. The study recruited 182 people, including 143 healthy volunteers and 39 Alzheimer disease patients. All underwent conventional magnetic resonance imaging and susceptibility weighted imaging sequences. The groups were divided according to age. Phase images were used to investigate iron deposition in the bilateral head of the caudate nucleus, globus pallidus and putamen, and the angle radian value was calculated. We hypothesized that age-related iron deposition changes may be different between Alzheimer disease patients and controls of the same age, and that susceptibility weighted imaging would be a more sensitive method of iron deposition quantification. The results revealed that iron deposition in the globus pallidus increased with age, up to 40 years. In the head of the caudate nucleus, iron deposition peaked at 60 years. There was a general increasing trend with age in the putamen, up to 50-70 years old. There was significant difference between the control and Alzheimer disease groups in the bilateral globus pallidus in both the 60-70 and 70-80 year old group comparisons. In conclusion, iron deposition increased with age in the globus pallidus, the head of the caudate nucleus and putamen, reaching a plateau at different ages. Furthermore, comparisons between the control and Alzheimer disease group revealed that iron deposition changes were more easily detected in the globus pallidus.
authors.affiliation: Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai 200233, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital of Harbin Medical University, Radiology Department, China.
authors.forename: Yan-Ying
authors.initials: YY
authors.lastname: Li
authors.affiliation: College of Life Science and Technology, Shanghai Jiaotong University, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Luo
authors.affiliation: Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai 200233, China. Electronic address: liyuehuaxp@gmail.com.
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism*; D001479:Basal Ganglia / Q000378:metabolism*; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000378:metabolism; D002648:Child; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D007501:Iron
keywords: Aging; Alzheimer disease; Iron deposition; Magnetic resonance imaging; Susceptibility weighted imaging