title: Induced hematopoietic stem cells: unlocking restrictions in lineage potential and self-renewal.
abstract: Obtaining sufficient numbers of immunologically matched hematopoietic stem cells (HSCs) poses a major clinical hurdle in bone marrow transplantation therapies. In a recent study in Cell, Riddell et al. (2014) generate induced HSCs from differentiated blood cells, which may serve as a potential solution to this clinical challenge.
authors.affiliation: Immunology Section, Institution for Experimental Medical Science, Lund University, Sölvegatan 17, BMC D14, 221 84, Lund, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Wahlestedt
authors.affiliation: Immunology Section, Institution for Experimental Medical Science, Lund University, Sölvegatan 17, BMC D14, 221 84, Lund, Sweden. Electronic address: david.bryder@med.lu.se.
authors.forename: David
authors.initials: D
authors.lastname: Bryder
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors