title: [Adipose tissue and cancer: a high risk tandem].
abstract: Adipose tissue is found in close proximity whith many invasive cancers. In breast cancer, early local tumour invasion results in close interactions of cancer cells with fully differentiated adipocytes. Aside from their energy-storing function, mature adipocytes are also active endocrine cells prone to influence tumour behaviour through heterotypic signaling processes. After a short description of anatomical depots specificities of adipose tissue, we describe the phenotypic changes induced by tumor secretion in tumour-surrounding adipocytes. These cells (that we named CAA for cancer-associated adipocytes) by their ability to secrete pro-inflammatory cytokines, extra-cellular matrix proteins and proteases involved in its remodeling, as well as to release free fatty acid, stimulate tumor proliferation, invasiveness and drug resistance. These results support the concept that adipocytes participate in a deleterious crosstalk with cancer cells to support tumour progression, that might be amplified in obesity conditions and explain the poor prognosis of cancers observed in this subset of patients.
authors.affiliation: Institut de pharmacologie et de biologie structurale, CNRS/université de Toulouse, UMR 5089, 205, route de Narbonne, BP 64182, 31077 Toulouse, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Laurent
authors.affiliation: Institut de pharmacologie et de biologie structurale, CNRS/université de Toulouse, UMR 5089, 205, route de Narbonne, BP 64182, 31077 Toulouse, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Nieto
authors.affiliation: Inserm U1048, Institut des maladies métaboliques et cardiovasculaires de Toulouse (I2MC), 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Valet
authors.affiliation: Institut de pharmacologie et de biologie structurale, CNRS/université de Toulouse, UMR 5089, 205, route de Narbonne, BP 64182, 31077 Toulouse, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Muller
mesh_terms: D017667:Adipocytes / Q000502:physiology; D000273:Adipose Tissue / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D012307:Risk Factors; D059016:Tumor Microenvironment