title: SAICAR binding activates PKM2 protein kinase activity.
abstract: SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation.
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D010766:Phosphorylation; D012265:Ribonucleotides / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D013963:Thyroid Hormones / Q000737:chemistry* / Q000378:metabolism; D000097810:Thyroid Hormone-Binding Proteins
chemical_list: D000620:Aminoimidazole Carboxamide; D002352:Carrier Proteins; D008565:Membrane Proteins; D012265:Ribonucleotides; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins; C020635:SAICAR