title: Lipoprotein-associated phospholipase A₂ mass level is increased in elderly subjects with type 2 diabetes mellitus.
abstract: OBJECTIVE. Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA₂ mass between them. METHODS. 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA₂ mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. RESULTS. Lp-PLA₂ mass was significantly elevated in this population (1296 ± 358 ng/mL before TAVI; 1413 ± 268 ng/mL before BA) and further increased after TAVI (1604 ± 437 ng/mL, P < 0.01) or BA (1808 ± 303 ng/mL, P < 0.01). Lp-PLA₂ mass was significantly increased on the diabetic group before these interventions. CONCLUSION. Lp-PLA₂ may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA₂ in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.
authors.affiliation: 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Fortunato
authors.affiliation: 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Bláha
authors.affiliation: 1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Bis
authors.affiliation: 1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Št'ásek
authors.affiliation: Department of Immunology and Alergology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: C
authors.initials: C
authors.lastname: Andrýs
authors.affiliation: 1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Vojáček
authors.affiliation: 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: B
authors.initials: B
authors.lastname: Jurašková
authors.affiliation: 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Sobotka
authors.affiliation: Department of Cardiosurgery, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Polanský
authors.affiliation: Department of Cardiosurgery, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Brtko
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000800:Angioplasty, Balloon / Q000009:adverse effects; D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery / Q000628:therapy; D050197:Atherosclerosis / Q000097:blood / Q000150:complications* / Q000201:enzymology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000209:etiology*; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human