title: Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity.
abstract: BACKGROUND
  ABO rs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABO rs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied.
  
  
  METHODS
  We genotyped 168 subjects for rs495828. ACE plasma activity and ABO histo-blood group were measured in all minor allele homozygous subjects (TT) that agreed to participate in the study (n=8) and in age- and gender-matched heterozygous subjects (GT; n=8) and major allele homozygous subjects (GG; n=8).
  
  
  RESULTS
  A non-significant trend was found in ACE activity among rs495828 genotype groups; however the polymorphism was significantly associated with ABO phenotype (p=0.007), which in turn was associated with ACE activity (p=0.029).
  
  
  CONCLUSIONS
  These results provide new evidence for the ABO-ACE relationship. Although the genetic marker studied here may be involved somehow, ABO phenotype is shown to be a better predictor of ACE plasma activity.
authors.affiliation: Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Gassó
authors.affiliation: Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain.
authors.forename: Marie A
authors.initials: MA
authors.lastname: Ritter
authors.affiliation: Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Mas
authors.affiliation: Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain amalialafuente@ub.edu.
authors.forename: Amalia
authors.initials: A
authors.lastname: Lafuente
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D005838:Genotype; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; D007703:Peptidyl-Dipeptidase A
keywords: ABO; angiotensin-converting enzyme activity; polymorphism; rs495828