title: A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis.
abstract: Population modeling of tumor size dynamics has recently emerged as an important tool in pharmacometric research. A series of new mixed-effects models have been reported recently, and we present herein a synthetic view of models with published mathematical equations aimed at describing the dynamics of tumor size in cancer patients following anticancer drug treatment. This selection of models will constitute the basis for the Drug Disease Model Resources (DDMoRe) repository for models on oncology.
authors.affiliation: INRIA, Project-Team NUMED, École Normale Supérieure de Lyon, Lyon, France.
authors.forename: B
authors.initials: B
authors.lastname: Ribba
authors.affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
authors.forename: N H
authors.initials: NH
authors.lastname: Holford
authors.affiliation: Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Magni
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Trocóniz
authors.affiliation: Global PK/PD Department, Lilly Research Laboratories, Surrey, UK.
authors.forename: I
authors.initials: I
authors.lastname: Gueorguieva
authors.affiliation: Merck Institute for Pharmacometrics, EPFL, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Girard
authors.affiliation: Advanced Quantitative Sciences Department, Novartis Pharma AG, Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Sarr
authors.affiliation: Optimata Ltd., Bene Ataroth, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Elishmereni
authors.affiliation: Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Kloft
authors.affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
authors.forename: L E
authors.initials: LE
authors.lastname: Friberg