title: Feline spinal cord gliomas: Clinicopathologic and diagnostic features of seven cases
abstract: Intraparenchymal spinal cord tumors in the cat are rarely reported and often as single case reports. In the current study, the clinical, magnetic resonance imaging (MRI), histologic, and immunohistochemical features of 7 cases of intraparenchymal spinal cord tumors in the cat are described. All cats were domestic breed, ranged from 4 to 12 years of age (median 8 years), and included spayed females (5/7) and neutered males (2/7). The duration of clinical signs ranged from 2 weeks to 3 months. MRI revealed lesions that were hyperintense on T2-weighted images with variable contrast enhancement. All 7 tumors had histologic features consistent with glial origin: 3 were astrocytic (gemistocytic or fibrous), and 2 were oligoastrocytic. Single cases of oligodendroglioma and gliomatosis cerebri were also present in the study. Glial fibrillary acidic protein immunoreactivity was robust in the tumors that were predominately astrocytic, and the gliomatosis cerebri case had extensive BLA.36 and Iba1 immunoreactivity. Ki-67 immunoreactivity was variable and most abundant in the case of malignant oligoastrocytoma. The majority of peritumoral lymphocytes were CD3 positive. The current study expands upon the known reports of spinal cord neoplasia in the cat, confirms a caudal cervical segment predilection, and includes a report of gliomatosis cerebri in the spinal cord of a cat.
authors.affiliation: Pieper Memorial Veterinary Center, Middletown, CT
authors.forename: James J
authors.initials: JJ
authors.lastname: Hammond
authors.affiliation: Department of Biomedical Sciences, Section of Anatomic
  Pathology, Cornell University, College of Veterinary Medicine, Ithaca, NY
authors.forename: Alexander
authors.initials: A
authors.lastname: deLahunta
authors.affiliation: Department of Neurology/Neurosurgery, Red Bank
  Veterinary Hospital, Tinton Falls, NJ
authors.forename: Eric N
authors.initials: EN
authors.lastname: Glass
authors.affiliation: Department of Small Animal
  Medicine and Surgery, College of Veterinary Medicine, University of
  Georgia, Athens, GA
authors.forename: Marc
authors.initials: M
authors.lastname: Kent
authors.affiliation: Department of Pathology and Infectious
  Diseases, Royal Veterinary College, Herts, UK
authors.forename: Brian A
authors.initials: BA
authors.lastname: Summers
authors.affiliation: Department of Biomedical Sciences, Section of Anatomic
  Pathology, Cornell University, College of Veterinary Medicine, Ithaca, NY
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002415:Cats; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009518:New York; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*
keywords: Feline; gliomas; immunohistochemical staining; spinal cord