title: PaTH: towards a learning health system in the Mid-Atlantic region.
abstract: The PaTH (University of Pittsburgh/UPMC, Penn State College of Medicine, Temple University Hospital, and Johns Hopkins University) clinical data research network initiative is a collaborative effort among four academic health centers in the Mid-Atlantic region. PaTH will provide robust infrastructure to conduct research, explore clinical outcomes, link with biospecimens, and improve methods for sharing and analyzing data across our diverse populations. Our disease foci are idiopathic pulmonary fibrosis, atrial fibrillation, and obesity. The four network sites have extensive experience in using data from electronic health records and have devised robust methods for patient outreach and recruitment. The network will adopt best practices by using the open-source data-sharing tool, Informatics for Integrating Biology and the Bedside (i2b2), at each site to enhance data sharing using centrally defined common data elements, and will use the Shared Health Research Information Network (SHRINE) for distributed queries across the network.
authors.affiliation: Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Waqas
authors.initials: W
authors.lastname: Amin
authors.affiliation: Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Fuchiang Rich
authors.initials: FR
authors.lastname: Tsui
authors.affiliation: Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Borromeo
authors.affiliation: Department of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Cynthia H
authors.initials: CH
authors.lastname: Chuang
authors.affiliation: Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Jeremy U
authors.initials: JU
authors.lastname: Espino
authors.affiliation: Department of Medicine, Division of Health Science Informatics, John Hopkins School of Medicine, Baltimore, Maryland, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ford
authors.affiliation: Department of Public Health Sciences, Division of Health Services Research, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Wenke
authors.initials: W
authors.lastname: Hwang
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Wishwa
authors.initials: W
authors.lastname: Kapoor
authors.affiliation: Department of Medicine, Division of Health Science Informatics, John Hopkins School of Medicine, Baltimore, Maryland, USA.
authors.forename: Harold
authors.initials: H
authors.lastname: Lehmann
authors.affiliation: Department of Critical Care Medicine, UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: G Daniel
authors.initials: GD
authors.lastname: Martich
authors.affiliation: Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Sally
authors.initials: S
authors.lastname: Morton
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Paranjape
authors.affiliation: Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: William
authors.initials: W
authors.lastname: Shirey
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Sorensen
authors.affiliation: Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Becich
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Hess
mesh_terms: D003195:Computer Communication Networks; D057286:Electronic Health Records / Q000458:organization & administration*; D006801:Humans; D033181:Information Dissemination; D008498:Medical Record Linkage; D008873:Mid-Atlantic Region; D017063:Outcome Assessment, Health Care / Q000458:organization & administration*; D018802:Patient-Centered Care
keywords: I2B2; clinical data research network (CDRN); distributed cohort query; electronic health records (EHRs); patient reported outcomes (PROs); patient-centered outcomes research (PCORI)