title: [Effect of Qiju Dihuang Pill on serum levels of IFN-gamma and IL-4 in pregnant women of Gan-Shen yin deficiency syndrome].
abstract: OBJECTIVE
  To observe the effect of Qiju Dihuang Pill (QDP) on changes of Chinese medical syndrome types in pregnant women of Gan-Shen yin deficiency syndrome (GSYDS), and to explore the correlation between imbalanced cytokine levels and GSYDS.
  
  
  METHODS
  This was a random controlled trail. A total of 163 pregnant women of GSYDS at 12 -16 gestational weeks were randomly allocated into the experimental group (86 cases) and the control group (77 cases). Patients in the experimental group took QDP for 2 -4 weeks. Changes of Chinese medical syndrome types and serum interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) levels were observed and compared between the two groups before and after treatment.
  
  
  RESULTS
  (1) Totally 41 patients (47.7%) in the experimental group were transformed to normal Chinese medical syndrome type. In the same period of the follow-ups, 9 patients (11.7%) in the control group were transformed to normal Chinese medical syndrome type, showing statistical difference (P < 0.05). (2) In the experimental group, the serum level of IFN-gamma and the ratio of IFN-gamma/IL-4 in the peripheral blood were obviously lower after treatment than before treatment (P < 0.01), and obviously lower than those in the control group (P < 0.01). The level of IL-4 after treatment in the experimental group was higher than that before treatment, and also higher than that in the control group, but with no statistical difference.
  
  
  CONCLUSIONS
  These results indicated that there was imbalanced IFN-gamma/IL-4 ratio in the peripheral blood of pregnant women of GSYDS. QDP might play a role in immunoregulation by affecting the IFN-gamma level.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Gu
authors.forename: Dao-Cheng
authors.initials: DC
authors.lastname: Li
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011247:Pregnancy; D016710:Yin Deficiency
chemical_list: D004365:Drugs, Chinese Herbal; C573415:IFNG protein, human; C508598:IL4 protein, human; D015847:Interleukin-4; D007371:Interferon-gamma