title: Hürthle cell neoplasms diagnosed by fine needle aspiration are not associated with an increased risk of malignancy.
abstract: OBJECTIVE
  The aim of this study is to determine the risk of neoplasm and malignancy in thyroid fine needle aspiration (FNA) diagnosed as atypia of undetermined significance with Hürthle cell change (AUS-H) or Hürthle cell neoplasm (HCN).
  
  
  METHODS
  A computerized search of our laboratory information system was performed to identify all thyroid FNA and correlating surgical pathology diagnoses including Hürthle cell or oncocyte in the diagnostic nomenclature. The risks of neoplasm and malignancy were calculated for AUS-H and HCN categories separately.
  
  
  RESULTS
  For the 29 AUS-H cases, the follow-up histology demonstrated 15 benign lesions, 4 follicular adenomas, 7 Hürthle cell adenomas, 1 papillary microcarcinoma (PMC), 1 follicular carcinoma and 1 Hürthle cell carcinoma. For the 93 HCN cases, the follow-up histology demonstrated 28 benign lesions, 9 follicular adenomas, 32 Hürthle cell adenomas, 2 PMCs, 2 papillary thyroid carcinomas, 6 follicular carcinomas and 14 Hürthle cell carcinomas.
  
  
  CONCLUSIONS
  The risks of neoplasm and malignancy were 62 and 7% for the AUS-H category and 73 and 24% for the HCN category, respectively. The risk of malignancy for the AUS-H patients is within the 5- to 15-percent range suggested by the Bethesda System for Reporting Thyroid Cytology and within the 15- to 30-percent range suggested for follicular neoplasms.
authors.affiliation: Indiana University School of Medicine, Indianapolis, Ind., USA.
authors.forename: Susan
authors.initials: S
authors.lastname: McKee
authors.forename: Howard
authors.initials: H
authors.lastname: Wu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Harvey
authors.initials: H
authors.lastname: Cramer
authors.forename: Jingmei
authors.initials: J
authors.lastname: Lin
authors.forename: Shaoxiong
authors.initials: S
authors.lastname: Chen
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D055815:Young Adult