title: Neurophysiological findings in a newborn with chromosome 10 trisomy.
abstract: The trisomy of the short arm of chromosome 10 is a rare condition. The phenotypic expression of this genetic aberration is characterised by growth and mental retardation with several neurological signs. We report the neurophysiological findings in a newborn affected by 10p chromosome trisomy who developed seizures. Serial EEGs showed a progressive reduction in burst-suppression activity and a slow rhythmic basal activity. At 1 year of age the recording showed for the first time spikes of high amplitude (up to 800 μV) in bilateral frontal regions. These findings could be related to an asymmetrical cerebral maturation in the context of perinatal sufferance and brain malformation due to the genetic aberration.
authors.affiliation: Sant'Anna Hospital, San Fermo della Battaglia, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Vidale
authors.forename: Franco
authors.initials: F
authors.lastname: Di Palma
authors.forename: Luigi
authors.initials: L
authors.lastname: Sironi
authors.forename: Marco
authors.initials: M
authors.lastname: Arnaboldi
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D001921:Brain / Q000503:physiopathology*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D019465:Craniofacial Abnormalities / Q000235:genetics*; D004569:Electroencephalography; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy / Q000235:genetics / Q000503:physiopathology*