title: Cinacalcet may improve oxidative DNA damage in maintenance hemodialysis patients: an observational study.
abstract: BACKGROUND
  Oxidative stress is accepted as a non-classical cardiovascular risk factor in patients on maintenance hemodialysis (HD). The aim of this study was to evaluate the impact of cinacalcet on oxidative stress biomarkers, oxidative DNA damage (8-hydroxy-2'-deoxyguanosine/deoxyguanosine), endothelial function (FMD %) and carotid artery intima-media thickness (CIMT) in HD patients.
  
  
  METHODS
  Forty-two chronic HD patients with secondary hyperparathyroidism undergoing 60 mg/day cinacalcet treatment with a follow-up of 6 months and 38 age- and sex-matched healthy individuals were included in this prospective study. Plasma malondialdehyde (MDA) levels and 8-hydroxy-2'-deoxyguanosine/deoxyguanosine ratio (8-OHdG/dG) were determined as oxidative stress markers. Superoxide dismutase (SOD), paraoxonase (PON), catalase (CAT), carbonic anhydrase (CAN) and glutathione peroxidase (GPx) activities were measured as antioxidants. FMD % and CIMT were assessed by ultrasonography.
  
  
  RESULTS
  MDA levels were decreased; SOD, PON, CAT, CAN and GPx activities were increased after 6 months of cinacalcet treatment in HD patients. Although CIMT remained stabile, there was a significant improvement in FMD % as well as a notable reduction trend in 8-OHdG/dG ratio after 6 months of treatment.
  
  
  CONCLUSIONS
  Our data have demonstrated that cinacalcet improves oxidative stress, genomic damage, endothelial function and increases antioxidant protection in HD patients after 6 months of treatment.
authors.affiliation: Department of Nephrology, Kartal Research and Training Hospital, 34890, Istanbul, Turkey, elifaribakir@gmail.com.
authors.forename: Elif
authors.initials: E
authors.lastname: Ari
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kaya
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: Ebru
authors.initials: E
authors.lastname: Asicioglu
authors.forename: Zehra
authors.initials: Z
authors.lastname: Eren
authors.forename: Eray
authors.initials: E
authors.lastname: Celik
authors.forename: Hakki
authors.initials: H
authors.lastname: Arikan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D050197:Atherosclerosis / Q000517:prevention & control*; D059168:Carotid Intima-Media Thickness; D000069449:Cinacalcet; D004249:DNA Damage / Q000187:drug effects*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000235:genetics; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology* / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D011446:Prospective Studies; D006435:Renal Dialysis
chemical_list: D009281:Naphthalenes; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D000069449:Cinacalcet