title: Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin.
abstract: It is currently accepted that ambient, non-genetic factors influence perinatal development and evoke structural and functional changes that may persist throughout life. Overfeeding and androgenization after birth are two of these key factors that could result in "metabolic imprinting" of neuronal circuits early in life and, thereby, increase the body weight homeostatic "set point", stimulate appetite, and result in obesity. Our aim was to determine the influence of these obesogenic factors on the response to ghrelin. We observed the expected orexigenic effect of ghrelin regardless of the nutritional or hormonal manipulations to which the animals were subjected to at early postnatal development and this effect remained intact at later stages of development. In fact, ghrelin responses increased significantly when the animals were subjected to one of the two manipulations, but not when both were combined. An increased response to ghrelin could explain the obese phenotype displayed by individuals with modified perinatal environment.
authors.affiliation: 1] Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain [2] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain.
authors.forename: Marta G
authors.initials: MG
authors.lastname: Novelle
authors.affiliation: 1] Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain [2] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Vázquez
authors.affiliation: 1] Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain [2] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain.
authors.forename: Kátia D
authors.initials: KD
authors.lastname: Martinello
authors.affiliation: 1] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain [2] Department of Cell Biology, Physiology and Immunology, School of Medicine, University of Córdoba - Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofia, Córdoba, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanchez-Garrido
authors.affiliation: 1] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain [2] Department of Cell Biology, Physiology and Immunology, School of Medicine, University of Córdoba - Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofia, Córdoba, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Tena-Sempere
authors.affiliation: 1] Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain [2] CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism* / Q000502:physiology*; D001066:Appetite / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005260:Female; D054439:Ghrelin / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D011181:Postnatal Care / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D014770:Virilism / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D054439:Ghrelin