title: DNA Aptamer Technology for Personalized Medicine.
abstract: This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus onin vivostudies for potential clinical applications. Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases. The use of aptamers as targeting agents in drug delivery is also covered. The advantages and future directions of such DNA aptamer-based technology for the continued development of personalized medicine are discussed.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 ; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
authors.forename: Hang
authors.initials: H
authors.lastname: Xing
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
authors.forename: Kevin
authors.initials: K
authors.lastname: Hwang
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 ; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
authors.forename: Seyed-Fakhreddin
authors.initials: SF
authors.lastname: Torabi
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 ; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 ; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
keywords: DNA aptamer; cancer; diagnosis; personalized medicine; targeted delivery; therapy