title: New antimicrobial and biocompatible implant coating with synergic silver-vancomycin conjugate action.
abstract: Materials foreign to the body are used ever more frequently, as increasing numbers of patients require implants. As a consequence, the numbers of implant-related infections have grown as well, and with increasing resistance. Treatments often fail; thus, new antibacterial coating strategies are being developed by scientists to avoid, or at least strongly reduce, bacterial adhesion to implant surfaces. In this study, we focused on producing a self-protective coating combining silver(I) ions and a vancomycin-derived molecule, intelligent pyridinate vancomycin (IPV), with a synergetic and effective action against bacteria. These Ag(I) -IPV conjugate-coated surfaces are well characterized and exhibit strong bactericidal activity in vitro against Staphylococci strains. Furthermore, the released quantities of both drugs from the coated surfaces do not affect their biocompatibility and soft tissue integration. These newly developed Ag(I) -IPV conjugate coatings thus represent a possible and efficient protection method against bacterial adhesion and biofilm formation during and after implant surgery.
authors.affiliation: Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg (Switzerland).
authors.forename: Massimo
authors.initials: M
authors.lastname: Varisco
authors.forename: Nina
authors.initials: N
authors.lastname: Khanna
authors.forename: Priscilla S
authors.initials: PS
authors.lastname: Brunetto
authors.forename: Katharina M
authors.initials: KM
authors.lastname: Fromm
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry; D051379:Mice; D008826:Microbial Sensitivity Tests; D012834:Silver / Q000737:chemistry*; D013210:Staphylococcus / Q000187:drug effects; D013499:Surface Properties; D014640:Vancomycin / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D056831:Coordination Complexes; D012834:Silver; D014640:Vancomycin; D006046:Gold
keywords: antimicrobial action; gold surfaces; medical implants; silver; vancomycin