title: Adipokines as potential biomarkers in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by severe joint injury. Recently, research has been focusing on the possible identification of predictor markers of disease onset and/or progression, of joint damage, and of therapeutic response. Recent findings have uncovered the role of white adipose tissue as a pleiotropic organ not only specialized in endocrine functions but also able to control multiple physiopathological processes, including inflammation. Adipokines are a family of soluble mediators secreted by white adipose tissue endowed with a wide spectrum of actions. This review will focus on the recent advances on the role of the adipokine network in the pathogenesis of RA. A particular attention will be devoted to the action of these proteins on RA effector cells, and on the possibility to use circulating levels of adipokines as potential biomarkers of disease activity and therapeutic response.
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy ; Humanitas Clinical and Research Center, via Manzoni 113, 20089 Rozzano, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Del Prete
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Salvi
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy ; Humanitas Clinical and Research Center, via Manzoni 113, 20089 Rozzano, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002460:Cell Line; D018946:Chemokine CCL5 / Q000235:genetics / Q000378:metabolism; D018120:Finasteride / Q000494:pharmacology; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016133:Polymerase Chain Reaction; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018946:Chemokine CCL5; D018120:Finasteride