title: The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses.
abstract: Upon antigenic stimulation, naïve CD8+T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis. This drives CD8+T cells to differentiate into short-lived effectors, impairing the establishment of immunological memory. The pharmacological inhibition of glycolysis with 2-deoxyglucose enhances the generation of memory CD8+T cells and thus improves their immunotherapeutic potential against cancer.
authors.affiliation: Surgery Branch; Center for Cancer Research; National Institutes of Health; Bethesda, MD USA.
authors.forename: Madhusudhanan
authors.initials: M
authors.lastname: Sukumar
authors.affiliation: Experimental Transplantation and Immunology Branch; National Institutes of Health; Bethesda, MD USA.
authors.forename: Luca
authors.initials: L
authors.lastname: Gattinoni
keywords: CD8+ T cells; adoptive immunotherapy; glycolysis; immune metabolism; memory T cells