title: The relationship between coronary collateral artery development and inflammatory markers.
abstract: OBJECTIVE
  This study aims to show the effect of myeloperoxidase (MPO), hsCRP, TNF-alpha values and leukocyte count on the development of coronary collateral arteries in patients with severely diseased coronary arteries.
  
  
  METHODS
  Current study is an observational cross-sectional study. In the study, 295 patients who had functional obstruction or total coronary occlusion at least 1 month on their angiograms were included. We divided the study population into two groups according to their collateral grade as good collateral (Group 1) (169 patients) and poor collateral (Group 2) (126 patients). Multiple logistic regression analysis was used for independent variables associated with the coronary collateral grade.
  
  
  RESULTS
  History of stable angina pectoris was statistically more prevalent in good collateral group (61.5% and 48.4%, p=0.025). Furthermore, MPO activation was higher in good collateral group and the difference was statistically significant (3.7 U/mL and 3.0 U/mL p=0.001). In multiple logistic regression analysis, stable angina pectoris [OR 1.7, 95% CI (1.05-2.8), p=0.03] and high MPO levels [OR 2.7, 95% CI (1.7-4.3), p<0.001] were found to be independent predictors of good collateral development.
  
  
  CONCLUSIONS
  We think that proinflammatory enzymes and cytokines released from these cells rather than inflammatory cells themselves may play an important role on the collateral development.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Başkent University; İstanbul-Turkey. di_oguz@hotmail.com.
authors.forename: Didem
authors.initials: D
authors.lastname: Oğuz
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Atmaca
authors.forename: Cağdaş
authors.initials: C
authors.lastname: Ozdöl
authors.forename: Ayhan Ongun
authors.initials: AO
authors.lastname: Ozdemir
authors.forename: Cansin Tulunay
authors.initials: CT
authors.lastname: Kaya
authors.forename: Cetin
authors.initials: C
authors.lastname: Erol
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003097:Collateral Circulation; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D009195:Peroxidase