title: Rho GTPases, oxidation, and cell redox control.
abstract: While numerous studies support regulation of Ras GTPases by reactive oxygen and nitrogen species, the Rho subfamily has received considerably less attention. Over the last few years, increasing evidence is emerging that supports the redox sensitivity of Rho GTPases. Moreover, as Rho GTPases regulate the cellular redox state by controlling enzymes that generate and convert reactive oxygen and nitrogen species, redox feedback loops likely exist. Here, we provide an overview of cellular oxidants, Rho GTPases, and their inter-dependence.
authors.affiliation: Department of Biochemistry and Biophysics; University of North Carolina; Chapel Hill, NC USA.
authors.forename: G Aaron
authors.initials: GA
authors.lastname: Hobbs
authors.affiliation: Department of Pharmacology; University of North Carolina; Chapel Hill, NC USA.
authors.forename: Bingying
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Pharmacology; University of North Carolina; Chapel Hill, NC USA; Department of Radiation Oncology, University of North Carolina; Chapel Hill, NC USA; Lineberger Comprehensive Cancer Center; University of North Carolina; Chapel Hill, NC USA.
authors.forename: Adrienne D
authors.initials: AD
authors.lastname: Cox
authors.affiliation: Department of Biochemistry and Biophysics; University of North Carolina; Chapel Hill, NC USA; Lineberger Comprehensive Cancer Center; University of North Carolina; Chapel Hill, NC USA.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Campbell
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D026361:Reactive Nitrogen Species / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism; D015290:Second Messenger Systems; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein; D003545:Cysteine
keywords: 2-electron oxidants; Ras GTPases; cysteine oxidation; free radicals; post-translational modifications; reactive nitrogen species; reactive oxygen species