title: Paraoxonase 1 activity and lipid profile in schizophrenic patients.
abstract: OBJECTIVE
  This study aimed to investigate the variations of paraoxonase 1 (PON1) activity and lipid profile in patients with schizophrenia and the association of this activity with the sociodemographic, clinical and therapeutical characteristics of this population.
  
  
  METHODS
  Our cross-sectional study included 140 schizophrenic patients and 119 control subjects aged respectively 37.3±10.4 and 41.4±10 years. PON1 activity was determined using Konelab 30™ equipment (Thermo Electron Corporation). Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (c-HDL) and low-density lipoprotein cholesterol (c-LDL) concentrations were determined using Cobas 6000™ (Roche Diagnostics), apolipoproteins (ApoA1, ApoB) and lipoprotein (a) (Lp(a)) were determined using Integra 400 plus (Roche Diagnostics).
  
  
  RESULTS
  Compared to controls, patients had no significant decrease of PON1 activity and significantly lower ApoA1, c-HDL levels, and significantly higher levels of TG, ApoB, Lp(a) and TC/c-HDL and ApoB/ApoA1 ratios. Furthermore, PON1 activity was correlated with TG/c-HDL ratio. The lowest PON1 activity was noted in obese patients, in paranoid sub-type and in patients treated with combination of typical and atypical antipsychotics without significant difference. Moreover, it was associated with gender and cigarette smoking but not with alcohol consumption status.
  
  
  CONCLUSIONS
  Schizophrenic patients had a decrease in PON1 activity and perturbations in their lipid profiles that contribute to increase the risk of cardiovascular diseases. In addition, our results revealed that there was no association between the decrease of PON1 activity and any demographic or clinical characteristics. Therefore, such patients require specific care, particularly with regard to their lipid profile.
authors.affiliation: Biochemistry-Toxicology Laboratory, University Hospital of Monastir, Tunisia; Research Laboratory "Vulnerability to Psychotic Disorders LR 05 ES 10", Psychiatry Department, University Hospital of Monastir, Tunisia. Electronic address: hajer_mabrouk@yahoo.fr.
authors.forename: Hajer
authors.initials: H
authors.lastname: Mabrouk
authors.affiliation: Psychiatry Department, University Hospital of Monastir, Tunisia.
authors.forename: Haithem
authors.initials: H
authors.lastname: Mechria
authors.affiliation: Research Laboratory "Vulnerability to Psychotic Disorders LR 05 ES 10", Psychiatry Department, University Hospital of Monastir, Tunisia; Psychiatry Department, University Hospital of Monastir, Tunisia.
authors.forename: Anouar
authors.initials: A
authors.lastname: Mechri
authors.affiliation: Biochemistry-Toxicology Laboratory, University Hospital of Monastir, Tunisia.
authors.forename: Islam
authors.initials: I
authors.lastname: Azizi
authors.affiliation: Biochemistry-Toxicology Laboratory, University Hospital of Monastir, Tunisia.
authors.forename: Fadoua
authors.initials: F
authors.lastname: Neffati
authors.affiliation: Biochemistry-Toxicology Laboratory, University Hospital of Monastir, Tunisia; Research Laboratory "Vulnerability to Psychotic Disorders LR 05 ES 10", Psychiatry Department, University Hospital of Monastir, Tunisia.
authors.forename: Wahiba
authors.initials: W
authors.lastname: Douki
authors.affiliation: Research Laboratory "Vulnerability to Psychotic Disorders LR 05 ES 10", Psychiatry Department, University Hospital of Monastir, Tunisia; Psychiatry Department, University Hospital of Monastir, Tunisia.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Gaha
authors.affiliation: Biochemistry-Toxicology Laboratory, University Hospital of Monastir, Tunisia.
authors.forename: Mohamed Fadhel
authors.initials: MF
authors.lastname: Najjar
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000201:enzymology*
chemical_list: D008055:Lipids; D043303:Aryldialkylphosphatase
keywords: Lipid profile; Paraoxonase (PON1); Schizophrenia