title: A transit compartment model unmasks OxyContin's reflective pharmacokinetics from urine measurements in humans.
abstract: The absorption pattern of orally administered OxyContin (OXC) reflected in urine indicates that its appearance into systemic circulation undergoes transit absorption delays. The authors developed an OXC transit-delay compartment model that identified a new source of oxycodone hydrochloride (OC): the rate of appearance of OC due to OXC tablet dissolution in transit through the gastrointestinal (GI) tract (R(a)(GI)), which is due to disintegration of OXC's AcroContin delivery system. R(a)(GI) is independent of the biphasic dissolution and release of OC from the delivery system. The authors conclude that an OXC transit-delay compartment model can be of value in the interpretation of OXC pharmacokinetics.
authors.forename: Oscar A
authors.initials: OA
authors.lastname: Linares
authors.forename: William E
authors.initials: WE
authors.lastname: Schiesser
authors.forename: Annemarie Daly
authors.initials: AD
authors.lastname: Linares
authors.forename: Darko
authors.initials: D
authors.lastname: Stefanovski
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Boston
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D016503:Drug Delivery Systems; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008954:Models, Biological; D010098:Oxycodone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D012995:Solubility; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D010098:Oxycodone
keywords: OxyContin; mathematical modeling; noroxycodone; oxycodone; oxymorphone; pharmacokinetics; transit-delay compartment model; urine