title: Mesenchymal stem cell based therapy for osteo-diseases.
abstract: Stem cell therapy in recent years has gained much attention as the modern therapeutic approach to treat diseases. Mesenchymal stem cells (MSCs) are seen as the most reliable cells applied in therapy over other stem cells because of their versatility. Bone and cartilage diseases (osteo-diseases) are the major target of therapy using MSCs. In this perspective, we have statistically analyzed the data available on clinical trials registry databases regarding the mesenchymal stem cell based therapy for a number of mentioned diseases and paid attention towards the osteodiseases. We report that MSC therapy for osteo-diseases needs optimization in its standards to achieve acceptable results so that we can apply it in daily routine clinical practice.
authors.affiliation: Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran; Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran.
authors.forename: Mohammad Mousaei
authors.initials: MM
authors.lastname: Ghasroldasht
authors.forename: Muhammad
authors.initials: M
authors.lastname: Irfan-Maqsood
authors.forename: Maryam M
authors.initials: MM
authors.lastname: Matin
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Bidkhori
authors.forename: Hojjat
authors.initials: H
authors.lastname: Naderi-Meshkin
authors.forename: Ali
authors.initials: A
authors.lastname: Moradi
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Bahrami
mesh_terms: D001847:Bone Diseases / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology
keywords: bone and cartilage diseases; cell based therapy; clinical trials; mesenchymal stem cells