title: New exposure biomarkers as tools for breast cancer epidemiology, biomonitoring, and prevention: a systematic approach based on animal evidence.
abstract: BACKGROUND
  Exposure to chemicals that cause rodent mammary gland tumors is common, but few studies have evaluated potential breast cancer risks of these chemicals in humans.
  
  
  OBJECTIVE
  The goal of this review was to identify and bring together the needed tools to facilitate the measurement of biomarkers of exposure to potential breast carcinogens in breast cancer studies and biomonitoring.
  
  
  METHODS
  We conducted a structured literature search to identify measurement methods for exposure biomarkers for 102 chemicals that cause rodent mammary tumors. To evaluate concordance, we compared human and animal evidence for agents identified as plausibly linked to breast cancer in major reviews. To facilitate future application of exposure biomarkers, we compiled information about relevant cohort studies.
  
  
  RESULTS
  Exposure biomarkers have been developed for nearly three-quarters of these rodent mammary carcinogens. Analytical methods have been published for 73 of the chemicals. Some of the remaining chemicals could be measured using modified versions of existing methods for related chemicals. In humans, biomarkers of exposure have been measured for 62 chemicals, and for 45 in a nonoccupationally exposed population. The Centers for Disease Control and Prevention has measured 23 in the U.S. population. Seventy-five of the rodent mammary carcinogens fall into 17 groups, based on exposure potential, carcinogenicity, and structural similarity. Carcinogenicity in humans and rodents is generally consistent, although comparisons are limited because few agents have been studied in humans. We identified 44 cohort studies, with a total of > 3.5 million women enrolled, that have recorded breast cancer incidence and stored biological samples.
  
  
  CONCLUSIONS
  Exposure measurement methods and cohort study resources are available to expand biomonitoring and epidemiology related to breast cancer etiology and prevention.
authors.affiliation: Silent Spring Institute, Newton, Massachusetts, USA.
authors.forename: Ruthann A
authors.initials: RA
authors.lastname: Rudel
authors.forename: Janet M
authors.initials: JM
authors.lastname: Ackerman
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Attfield
authors.forename: Julia Green
authors.initials: JG
authors.lastname: Brody
mesh_terms: D000818:Animals; D015415:Biomarkers; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D002273:Carcinogens; D015331:Cohort Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental; D016273:Occupational Exposure; D018570:Risk Assessment; D012377:Rodentia
chemical_list: D015415:Biomarkers; D002273:Carcinogens