title: FTO gene: association to weight regain after lifestyle intervention in overweight children.
abstract: OBJECTIVE
  Polymorphisms in intron 1 of the 'fat mass and obesity-associated' (FTO) gene are associated with weight status. We hypothesized that the risk allele at a polymorphism in intron 1 of FTO is associated with weight regain after end of lifestyle intervention.
  
  
  METHODS
  We longitudinally analyzed the changes of weight status as BMI-SDS in 346 unrelated overweight children (mean age 10.6 ± 2.6 years, 45% male, mean BMI-SDS 2.39 ± 0.49) both at the end of a 1-year lifestyle intervention and 1 year after the end of this intervention. We genotyped the obesity risk SNP rs9939609 at FTO by ARMS-PCR.
  
  
  RESULTS
  The children reduced their BMI-SDS (-0.29 ± 0.33; p < 0.001) during intervention and increased their BMI-SDS between the end of intervention and 1 year later (+0.10 ± 0.41; p < 0.001). The obesity risk allele at FTO SNP rs9939609 was not associated with BMI-SDS reduction during the lifestyle intervention (p = 0.622), but with weight regain 1 year after end of the intervention in multiple linear regression analyses adjusted for age, sex, pubertal stage, and baseline BMI-SDS (Bonferroni corrected p = 0.002).
  
  
  CONCLUSIONS
  The obesity risk allele at a polymorphism in intron 1 of FTO was associated with weight regain 1 year after a 1-year lifestyle intervention.
authors.affiliation: Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Reinehr
authors.forename: Barbara
authors.initials: B
authors.lastname: Wolters
authors.forename: Christian L
authors.initials: CL
authors.lastname: Roth
authors.forename: Anke
authors.initials: A
authors.lastname: Hinney
mesh_terms: D000293:Adolescent; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008019:Life Style; D008297:Male; D050177:Overweight / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human