title: [Disease notification and self-determination in treatment decisions for patients with Creutzfeldt-Jakob disease].
abstract: We investigated disease notification and self-determination in treatment decisions of Creutzfeldt-Jakob disease (CJD). For this purpose, we retrospectively analyzed 18 patients with CJD (sporadic:familial = 14:4) who were admitted to our hospital. The durations from symptom onset to the time of diagnosis ranged from 0.3 to 48 months (median, 2 months). The Hasegawa Dementia Scale-revised (HDS-R) range was 0 to 29 (median, 5.0); however, 4 patients (22%), including 2 with familial CJD and 2 with sporadic CJD, maintained cognitive function (HDS-R score ≥ 21). Two patients (11%), who satisfied Lo's criteria for self-determination, were given a disease notification, and both of them archived self-determination in treatment decisions. In conclusion, we demonstrated that patients with CJD could be given a disease notification and archive self-determination in treatment decisions upon early diagnosis using DWI.
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Yanagimura
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Shimohata
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Tada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nozaki
authors.forename: Masatoyo
authors.initials: M
authors.lastname: Nishizawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging; D018563:Disease Notification; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D026684:Personal Autonomy