title: IL-6, IL-8, and IL-10 are associated with hyperferritinemia in rapidly progressive interstitial lung disease with polymyositis/dermatomyositis.
abstract: OBJECTIVE
  Hyperferritinemia is frequently accompanied by rapidly progressive (RP) interstitial lung disease (ILD) with polymyositis (PM)/dermatomyositis (DM). To clarify the mechanism of RP-ILD with hyperferritinemia, we investigated the associations between serum ferritin levels and various cytokines in patients with PM/DM.
  
  
  METHODS
  This retrospective study included 38 patients admitted to our hospital with PM/DM. Levels of serum ferritin and cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-18, TNF-α, IFN-α, IFN-γ, and IP-10) were measured. Disease activity was evaluated using the tool proposed by the International Myositis Assessment and Clinical Studies Group. We analyzed the associations between disease activity and levels of serum ferritin and cytokines.
  
  
  RESULTS
  The levels of serum ferritin, IL-8, IL-10, IL-18, and TNF-α, were significantly correlated with disease activity. In a multivariate analysis, IL-6 (t = 3.6, P = 0.0010), IL-8 (t = 4.8, P < 0.0001), and IL-10 (t = 5.7, P < 0.0001) significantly contributed to serum ferritin levels. The levels of serum ferritin, IL-6, IL-8, and IL-10, were higher in the RP-ILD subset than in the non-ILD subset or the chronic ILD subset.
  
  
  CONCLUSIONS
  IL-6, IL-8, and IL-10 are significant contributors to hyperferritinemia in PM/DM. The regulation of these cytokines might offer a possible treatment strategy for RP-ILD with PM/DM.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Hidenaga
authors.identifier: 0000-0003-2970-0548
authors.initials: H
authors.lastname: Kawasumi
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Takahisa
authors.identifier: 0000-0003-2964-6377
authors.initials: T
authors.lastname: Gono
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawaguchi
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katsumata
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Masanori
authors.identifier: 0000-0002-6638-9894
authors.initials: M
authors.lastname: Hanaoka
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Kataoka
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-Cho, Shinjuku-Ku, Tokyo 162-0054, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D000328:Adult; D003882:Dermatomyositis / Q000097:blood / Q000150:complications / Q000453:epidemiology; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007378:Interleukins / Q000097:blood*; D019189:Iron Metabolism Disorders / Q000097:blood / Q000150:complications / Q000453:epidemiology; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D007378:Interleukins; D005293:Ferritins