title: Identifying pseudogenes from hypothetical proteins for making synthetic proteins.
abstract: Nature selected certain regions of the genome for encoding proteins. Most of the sequences were used to encode only RNA. What happened to the remaining sections of the genome? It is possible that some sequences were retired and retained as non-functional entities called pseudogenes. Though several evolutionary prospects with functional endpoints exist, we looked at the possibility of hypothetical proteins correlating with the emergence of pseudogenes and potential of such genes to make novel synthetic molecules. In this commentary, we consider two key aspects: (1) does any correlation exist between hypothetical proteins and pseudogenes and (2)-can we make novel and functional proteins from pseudogenes?
authors.affiliation: Department of Computational Biology and Bioinformatics, University of Kerala, Kariyavattom Campus, Thiruvananthapuram, 695581 Kerala India.
authors.forename: P R
authors.initials: PR
authors.lastname: Shidhi
authors.affiliation: Department of Computational Biology and Bioinformatics, University of Kerala, Kariyavattom Campus, Thiruvananthapuram, 695581 Kerala India.
authors.forename: Achuthsankar S
authors.initials: AS
authors.lastname: Nair
authors.affiliation: Bioclues.Org, Hyderabad, India ; Bioinformatics.Org, 28 Pope Street, Hudson, MA 01749 USA.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Suravajhala
keywords: Hypothetical proteins; Pseudogenes; Synthetic proteins