title: An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media.
abstract: Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum's acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives.
authors.affiliation: Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416 , Tehran, Iran.
authors.forename: Saber
authors.initials: S
authors.lastname: Mehrparvar
authors.forename: Saeed
authors.initials: S
authors.lastname: Balalaie
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Rabbanizadeh
authors.forename: Elmira
authors.initials: E
authors.lastname: Ghabraie
authors.forename: Frank
authors.initials: F
authors.lastname: Rominger
mesh_terms: D000588:Amines / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D010710:Phosphates / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000588:Amines; D002264:Carboxylic Acids; D010710:Phosphates; C024788:ammonium phosphate; D014867:Water