title: Xenobiotic transporter expression along the male genital tract.
abstract: The male genital tract plays an important role in protecting sperm by forming a distinct compartment separate from the body which limits exposure to potentially toxic substrates. Transporters along this tract can influence the distribution of xenobiotics into the male genital tract through efflux back into the blood or facilitating the accumulation of toxicants. The aim of this study was to quantitatively determine the constitutive mRNA expression of 30 xenobiotic transporters in caput and cauda regions of the epididymis, vas deferens, prostate, and seminal vesicles from adult Sprague-Dawley rats. The epididymis was found to express at least moderate levels of 18 transporters, vas deferens 15, seminal vesicles 23, and prostate 18. Constitutive expression of these xenobiotic transporters in the male genital tract may provide insight into the xenobiotics that can potentially be transported into these tissues and may provide the molecular mechanism for site specific toxicity of select agents.
authors.affiliation: University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721, United States.
authors.forename: David M
authors.initials: DM
authors.lastname: Klein
authors.affiliation: University of Arizona, Department of Physiology, Tucson, AZ 85721, United States.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Wright
authors.affiliation: University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721, United States. Electronic address: cherrington@pharmacy.arizona.edu.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Cherrington
mesh_terms: D000818:Animals; D001692:Biological Transport; D005837:Genitalia, Male / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins; D012333:RNA, Messenger; D015262:Xenobiotics
keywords: Drug transport; Male genital tract; Multidrug resistance proteins; Toxicology; Xenobiotics