title: Biochemical modifications and neuronal damage in brain of young and adult rats after long-term exposure to mobile phone radiations.
abstract: This study investigated the effect of exposure to mobile phone radiations on oxidative stress and apoptosis in brain of rats. Rats were allocated into six groups (three young and three adult). Groups 1 and 4 were not subjected to the radiation source and served as control groups. In groups 2 and 5, the mobile phones were only connected to the global system for mobile communication, while in groups 3 and 6, the option of calling was in use. Microwaves were generated by a mobile test phone (SAR = 1.13 W/kg) during 60 days (2 h/day). Significant increments in conjugated dienes, protein carbonyls, total oxidant status, and oxidative stress index along with a significant reduction of total antioxidant capacity levels were evident after exposure. Bax/Bcl-2 ratio, caspase-3 activity, and tumor necrosis factor-alpha level were enhanced, whereas no DNA fragmentation was detected. The relative brain weight of young rats was greatly affected, and histopathological examination reinforced the neuronal damage. The study highlights the detrimental effects of mobile phone radiations on brain during young and adult ages. The interaction of these radiations with brain is via dissipating its antioxidant status and/or triggering apoptotic cell death.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Cairo University, Kasr Al-Aini Street, Cairo, 11562, Egypt.
authors.forename: Tarek K
authors.initials: TK
authors.lastname: Motawi
authors.forename: Hebatallah A
authors.initials: HA
authors.lastname: Darwish
authors.forename: Yasser M
authors.initials: YM
authors.lastname: Moustafa
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Labib
mesh_terms: D000367:Age Factors; D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D015415:Biomarkers / Q000378:metabolism; D001835:Body Weight / Q000528:radiation effects; D001921:Brain / Q000166:cytology / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects*; D040421:Cell Phone; D053938:DNA Fragmentation / Q000528:radiation effects; D008872:Microwaves / Q000009:adverse effects*; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D009929:Organ Size / Q000528:radiation effects; D018384:Oxidative Stress / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D015415:Biomarkers