title: Risk of reactivation of toxoplasmic retinitis following intraocular procedures without the use of prophylactic therapy.
abstract: OBJECTIVE
  Toxoplasmic retinochoroiditis is the commonest known cause of posterior uveitis worldwide and reactivation is unpredictable. Based on results from one study, the authors proposed that antitoxoplasmic therapy should be initiated as prophylaxis for intraocular surgery in patients with toxoplasmic scars. The aim of this study is to analyse the risk of toxoplasmic retinochoroiditis reactivation following intraocular procedures.
  
  
  METHODS
  Retrospective analysis of the medical records of a total of 69 patients who underwent intraocular surgery and presented with toxoplasmic retinochoroiditis scars.
  
  
  RESULTS
  No patient received prophylactic antitoxoplasmic therapy. Reactivation following the surgical procedure occurred in four cases, with one at 3 months and the others respectively at 13, 14 and 17 months.
  
  
  CONCLUSIONS
  Our study shows that intraocular surgery did not result in a significant reactivation rate of toxoplasmic retinochoroiditis in the absence of preoperative prophylactic antitoxoplasmic therapy.
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Gustavo C
authors.initials: GC
authors.lastname: Heringer
authors.affiliation: Moorfields Eye Hospital, London, UK.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Oueghlani
authors.affiliation: Moorfields Eye Hospital, London, UK.
authors.forename: Roberto
authors.initials: R
authors.lastname: Dell'Omo
authors.affiliation: Instituto de Pesquisa Clínica Evandro Chagas-IPEC/Fiocruz, Rio de Janeiro, Brazil.
authors.forename: André L L
authors.initials: AL
authors.lastname: Curi
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Oréfice
authors.affiliation: Moorfields Eye Hospital, London, UK.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Pavésio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002825:Chorioretinitis / Q000209:etiology* / Q000517:prevention & control; D003049:Coccidiostats / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D013530:Surgical Wound Infection / Q000209:etiology* / Q000517:prevention & control; D014126:Toxoplasmosis, Ocular / Q000209:etiology* / Q000517:prevention & control; D014821:Vitrectomy; D055815:Young Adult
chemical_list: D003049:Coccidiostats
keywords: Infection; Inflammation