title: Alcoholic liver disease: a synopsis of the Charles Lieber's Memorial Symposia 2009-2012.
abstract: This paper is based upon the 'Charles Lieber Satellite Symposia' organized by Manuela G. Neuman at each of the 2009-2012 Research Society on Alcoholism (RSA) Annual Meetings. The presentations represent a broad spectrum dealing with alcoholic liver disease (ALD). In addition, a literature search (2008-2013) in the discussed area was performed in order to obtain updated data. The presentations are focused on genetic polymorphisms of ethanol metabolizing enzymes and the role of cytochrome P4502E1 (CYP2E1) in ALD. In addition, alcohol-mediated hepatocarcinogenesis, immune response to alcohol and fibrogenesis in alcoholic hepatitis as well as its co-morbidities with chronic viral hepatitis infections in the presence or absence of human deficiency virus are discussed. Finally, emphasis was led on alcohol and drug interactions as well as liver transplantation for end-stage ALD.
authors.affiliation: In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, ON, Canada Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada manuela.neuman@utoronto.ca.
authors.forename: Manuela G
authors.initials: MG
authors.lastname: Neuman
authors.affiliation: Division of Gastroenterology, Sunnybrook Health Sciences Centre, Department of Medicine, Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Cohen
authors.affiliation: Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Samir
authors.initials: S
authors.lastname: Zakhari
authors.affiliation: In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, ON, Canada Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Radu M
authors.initials: RM
authors.lastname: Nanau
authors.affiliation: Centre of Alcohol Research, University of Heidelberg and Department of Medicine (Gastroenterology and Hepatology), Salem Medical Centre, Heidelberg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Mueller
authors.affiliation: Alcohol and Drug Abuse Research Unit, Medical Research Council, Stellenbosch University, Cape Town, South Africa.
authors.forename: Michelle
authors.initials: M
authors.lastname: Schneider
authors.affiliation: Alcohol and Drug Abuse Research Unit, Medical Research Council, Stellenbosch University, Cape Town, South Africa Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
authors.forename: Charles
authors.initials: C
authors.lastname: Parry
authors.affiliation: In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, ON, Canada Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Romina
authors.initials: R
authors.lastname: Isip
authors.affiliation: Centre of Alcohol Research, University of Heidelberg and Department of Medicine (Gastroenterology and Hepatology), Salem Medical Centre, Heidelberg, Germany.
authors.forename: Helmut K
authors.initials: HK
authors.lastname: Seitz
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D065700:Cytochrome P-450 CYP2E1 Inducers / Q000493:pharmacokinetics / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000493:pharmacokinetics*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D019698:Hepatitis C, Chronic / Q000150:complications / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000009:adverse effects; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000201:enzymology* / Q000235:genetics; D016031:Liver Transplantation / Q000401:mortality
chemical_list: D065700:Cytochrome P-450 CYP2E1 Inducers; D006635:Histamine H2 Antagonists; D000431:Ethanol