title: Atrial fibrillation burden in Myotonic Dystrophy type 1 patients implanted with dual chamber pacemaker: the efficacy of the overdrive atrial algorithm at 2 year follow-up.
abstract: The role that atrial pacing therapy plays on the atrial fibrillation (AF) burden is still unclear. Aim of the study was to evaluate the effect of the atrial preference pacing algorithm on AF burden in patients affected by Myotonic Dystrophy type 1 (DM1) followed for a long follow up period. Sixty DM1 patients were -implanted with a dual chamber pacemaker (PM) for first degree or symptomatic type 1/type 2 second degree atrio-ventricular blocks- were followed for 2-years after implantation, by periodical examination. After 1 month of stabilization, they were randomized into two groups: 1) Patients implanted with conventional dual-chamber pacing mode (DDDR group) and 2) Patients implanted with DDDR plus Atrial Preference Pacing (APP) algorithm (APP ON group). The results showed that atrial tachycardia (AT)/AF burden was significantly reduced at 1 year follow up in the APP ON group (2122 ± 428 minutes vs 4127 ± 388 minutes, P = 0.03), with a further reduction at the end of the 2 year follow up period (4652 ± 348 minutes vs 7564 ± 638 minutes, P = 0.005). The data here reported show that the APP is an efficient algorithm to reduce AT/AF burden in DM1 patients implanted with dual chamber pacemaker.
authors.affiliation: Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy;
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Russo
authors.affiliation: Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy;
authors.forename: Gerardo
authors.initials: G
authors.lastname: Nigro
authors.affiliation: Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy;
authors.forename: Anna
authors.initials: A
authors.lastname: Rago
authors.affiliation: Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy;
authors.forename: Andrea
authors.initials: A
authors.lastname: Antonio Papa
authors.affiliation: Cardiac Electrophysiology Service, McGill University Health Center, Montreal, Canada;
authors.forename: Riccardo
authors.initials: R
authors.lastname: Proietti
authors.affiliation: Department of Anesthesiology, Monaldi Hospital, Naples, Italy;
authors.forename: Nadia
authors.initials: N
authors.lastname: Della Cioppa
authors.affiliation: Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy;
authors.forename: Anna
authors.initials: A
authors.lastname: Cristiano
authors.affiliation: Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Palladino
authors.affiliation: Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy;
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
authors.affiliation: Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Politano
mesh_terms: D000465:Algorithms; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000503:physiopathology*; D016896:Treatment Outcome
keywords: Atrial overdrive algorithm; Myotonic Dystrophy type 1; atrial preference pacing; supraventricular tachyarrhythmias