title: Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.
abstract: OBJECTIVE
  To summarize the relationship between p.Tyr113His and p.His139Arg polymorphisms in microsomal epoxide hydrolase (EPHX1) and risk for esophageal cancer (EC).
  
  
  METHODS
  The MEDLINE/PubMed and EMBASE databases were searched for studies of the association between EPHX1 polymorphisms and EC risk that were published from the database inception date to April 2013. A total of seven case-control studies, including seven on p.Tyr113His (cases, n = 1118; controls, n = 1823) and six on p.His139Arg (cases, n = 861; controls, n = 1571), were included in the meta-analysis. After data extraction by two investigators working independently, the meta-analyses were carried out with STATA 11.0 software. Pooled odds ratios and 95%CI were calculated using a fixed-effects model or a random-effects model, as appropriate.
  
  
  RESULTS
  The pooled EPHX1 p.Tyr113His polymorphism data showed no significant association with EC in any of the genetic models (OR = 1.00, 95%CI: 0.70-1.48 for Tyr/His vs Tyr/Tyr; OR = 1.10, 95%CI: 0.77-1.57 for His/His vs Tyr/Tyr; OR = 1.06, 95%CI: 0.75-1.49 for a dominant model; OR = 1.09, 95%CI: 0.89-1.34 for a recessive model). Similar results were obtained from the p.His139Arg polymorphism analysis (Arg/His vs His/His: OR = 1.02, 95%CI: 0.84-1.23; Arg/Arg vs His/His: OR = 0.96, 95%CI: 0.60-1.54; OR = 1.03, 95%CI: 0.78-1.37 for the dominant model; OR = 0.97, 95%CI: 0.61-1.56 for the recessive model). Subgroup analyses for ethnicity, subtype of EC, and source of controls (population-based or hospital-based) showed trends that were consistent with the pooled analysis (reported above), with no significant associations found.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the p.Tyr113His and p.His139Arg polymorphisms in EPHX1 may not be associated with EC development.
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Qin-Tao
authors.initials: QT
authors.lastname: Li
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Kang
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Qin-Tao Li, Wei Kang, Man Wang, Jun Yang, Yang Zuo, Wei Zhang, Dan-Ke Su, Radiology Department, Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Dan-Ke
authors.initials: DK
authors.lastname: Su
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D004851:Epoxide Hydrolases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D004851:Epoxide Hydrolases; C522330:EPHX1 protein, human
keywords: Adenocarcinoma; EPHX1; Esophageal cancer; Meta-analysis; Polymorphism; Squamous cell carcinoma