title: Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation.
abstract: Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of EMBO Molecular Medicine, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been used in humans, is shown to boost humoral immunity primarily by acting on monocyte-derived dendritic cells. This study provides novel insight on the mode of action of adjuvant targeting Toll-like receptors.
authors.affiliation: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Berlin, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Fillatreau
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology*; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000502:physiology*
chemical_list: D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D009838:Oligodeoxyribonucleotides