title: A Probiotic Preparation Duolac-Gold Ameliorates Dextran Sulphate Sodium-induced Mouse Colitis by Downregulating the Expression of IL-6.
abstract: Probiotics are live microorganisms that confer a health benefit on the host. Duolac-Gold is a mixture of six probiotic bacteria containing three species of Bifidobacteria, two species of Lactobacillus, and Streptococcus thermophilus [corrected]. The aim of this study was to assess the anti-inflammatory effects of Duolac-Gold in an inflammatory bowel disease (IBD) mouse model. IBD was induced by administering 1.5% dextran sulfate sodium (DSS) for 10 days. After induction of DSS-induced colitis, Duolac-Gold was orally administered at three different concentrations. Interestingly, Duolac-Gold treatment accelerated IBD healing, and anti-inflammatory activity was assessed by weight loss, length of the colon, and a microscopic damage score by histology. The expression of inflammatory related cytokines was measured in colon tissues and serum. Of these cytokines, the expression of interleukin-6 decreased remarkably after Duolac-Gold treatment. Taken together, these results suggest that Duolac-Gold treatment is effective in IBD healing by regulating IL-6.
authors.affiliation: R&D Center, Cellbiotech Co. Ltd., Gimpo, Korea.
authors.forename: Hyunho
authors.initials: H
authors.lastname: Yoon
authors.affiliation: R&D Center, Cellbiotech Co. Ltd., Gimpo, Korea.
authors.forename: Yeo-Sang
authors.initials: YS
authors.lastname: Yoon
authors.affiliation: R&D Center, Cellbiotech Co. Ltd., Gimpo, Korea.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.affiliation: R&D Center, Cellbiotech Co. Ltd., Gimpo, Korea.
authors.forename: Myung-Jun
authors.initials: MJ
authors.lastname: Chung
authors.affiliation: R&D Center, Cellbiotech Co. Ltd., Gimpo, Korea.
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Yum
keywords: Cytokines; Duolac-gold; Inflammatory bowel disease; Interleukin-6; probiotics