title: Antioxidants: The new frontier for translational research in cerebroprotection.
abstract: It is important for the anesthesiologist to understand the etiology of free radical damage and how free-radical scavengers attenuate this, so that this knowledge can be applied to diverse neuro-pathological conditions. This review will concentrate on the role of reactive species of oxygen in the pathophysiology of organ dysfunction, specifically sub arachnoid hemorrhage (SAH), traumatic brain injury (TBI) as well as global central nervous system (CNS) hypoxic, ischemic and reperfusion states. We enumerate potential therapeutic modalities that are been currently investigated and of interest for future trials. Antioxidants are perhaps the next frontier of translational research, especially in neuro-anesthesiology.
authors.affiliation: Department of Anesthesiology, Dayanand Medical College, Ludhiana, Punjab, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Tewari
authors.affiliation: Department of Anesthesiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Vidhi
authors.initials: V
authors.lastname: Mahendru
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Drexel University College of Medicine, Philadelphia, USA.
authors.forename: Ashish
authors.initials: A
authors.lastname: Sinha
authors.affiliation: Department of Anesthesiology, Critical Care and Pain Medicine, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Bilotta
keywords: Antioxidants; cerebroprotection; neuro-anesthesiology; neurocritical care