title: SKIP expression is correlated with clinical prognosis in patients with bladder cancer.
abstract: The Ski-interacting protein (SKIP) is a transcriptional cofactor distinct from other cofactors and is involved in regulation of many cancer-related proteins. However, its distribution and clinical significances in bladder cancer remains poorly understood. In this study, Quantitative real-time PCR and immunohistochemistry were performed to detect the expression of SKIP in clinical bladder cancer samples. In addition, the correlation of SKIP expression and clinicopathological features and clinical outcomes were analyzed. The expression levels of SKIP in clinical bladder cancer were much higher than that in paired adjacent noncancerous tissues. High expression of SKIP was closely related with histological grades and the poor prognosis of bladder cancer. Based on our data, we speculated that SKIP may be a potential prognostic marker in bladder cancer.
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Longwang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, Wuhan Central Hospital Hubei Province, 430014, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Zimin
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Huang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D012189:Retrospective Studies; D015996:Survival Rate; D001743:Urinary Bladder / Q000378:metabolism / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D012333:RNA, Messenger; C466999:SPHKAP protein, human
keywords: SKIP expression; bladder cancer; prognosis