title: Young female with acromegaloid features and pituitary macroadenoma: what is your diagnosis?
abstract: Pseudoacromegaly is a extremely rare condition previously described and characterized by acromegaloid changes, tissue overgrowth, without elevations in insulin-like growth factor or growth hormone as seen in Acromegaly. We present the case of a young female seen initially with acromegaloid features and a pituitary microadenoma. After work-up the patient was diagnosed as insulin-mediated pseudoacromegaly. Only a few cases of pseudoacromegaly has been reported and should always be considered when evaluating patients for acromegaloid features with negative biochemical and hormonal levels.
authors.forename: José
authors.initials: J
authors.lastname: Hernán Martínez
authors.forename: Carlos
authors.initials: C
authors.lastname: Figueroa-Núñez
authors.forename: Paola
authors.initials: P
authors.lastname: Mansilla-Letelier
authors.forename: Coromoto
authors.initials: C
authors.lastname: Palermo-Garofalo
authors.forename: Mónica
authors.initials: M
authors.lastname: Santiago
authors.forename: Oberto
authors.initials: O
authors.lastname: Torres
authors.forename: Rafael
authors.initials: R
authors.lastname: Trinidad
authors.forename: Michelle
authors.initials: M
authors.lastname: Mangual-García
authors.forename: Alfredo
authors.initials: A
authors.lastname: Sánchez
authors.forename: Madelin
authors.initials: M
authors.lastname: Gutierrez
authors.forename: María de Lourdes
authors.initials: Mde L
authors.lastname: Miranda
authors.forename: Eva
authors.initials: E
authors.lastname: González
mesh_terms: D000052:Acanthosis Nigricans / Q000209:etiology; D000172:Acromegaly / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use; D000077465:Cabergoline; D003937:Diagnosis, Differential; D004873:Ergolines / Q000627:therapeutic use; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006628:Hirsutism / Q000209:etiology; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D010911:Pituitary Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011252:Pregnancy Complications, Neoplastic; D011378:Prognathism / Q000209:etiology; D015175:Prolactinoma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism
chemical_list: D004873:Ergolines; D007328:Insulin; D019382:Human Growth Hormone; D001971:Bromocriptine; D007334:Insulin-Like Growth Factor I; D000077465:Cabergoline