title: The Hedgehog pathway: potential biomarker and therapeutic applications in urologic malignancies.
abstract: The Hedgehog pathway has been implicated in the development of several non-urologic malignancies. Recent work suggests that the activation of the glioma-associated GLi family of zinc finger transcription factors may play a role in some urologic malignancies. This review surveys the potential role of the Hedgehog pathway as a new class of biomarker in some urologic cancers.
authors.affiliation: Division of Urology, Department of Surgery, Brigham and Women's Hospital, Boston, MA. Electronic address: kloughlin@partners.org.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Loughlin
mesh_terms: D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*; D000071676:Zinc Finger Protein GLI1
chemical_list: C400551:GLI1 protein, human; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1
keywords: Biomarker; Hedgehog pathway; Urologic malignancies