title: The effect of lipocisplatin on cisplatin efficacy and nephrotoxicity in malignant breast cancer treatment.
abstract: A lipid-cisplatin conjugate was synthesized for super-molecular assembly with lipids to form a new generation of liposomal cisplatin formulation, lipocisplatin. In vitro, lipocisplatin has higher efficacy in human ovarian cancer A2780 and human breast cancer MCF-7 with the murine breast cancer cell line 4T1 which is currently an established model for stage IV breast cancer as the most sensitive strain. Moreover, lipocisplatin demonstrated a greater MTD value and relatively longer blood circulation as compared to cisplatin. Lipocisplatin preferentially accumulate drugs to the tumor site, resulting in a better tumor inhibition efficacy. Moreover, lipocisplatin exceeds the size cutoff for kidney clearance, hence it bypasses the nephrotoxicity of cisplatin which is a major curse of one of the most efficient anticancer drugs nowadays in clinic. The results here indicated lipocisplatin may be translated into a new generation of liposomal based cisplatin drug in clinic.
authors.affiliation: Department of Oncology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.affiliation: University Town, Ganzhou Development District, Jiangxi Province, Gannan Medical University, 341000, China.
authors.forename: Yuantong
authors.initials: Y
authors.lastname: Tian
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Dandi
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Donglei
authors.initials: D
authors.lastname: Shi
authors.affiliation: Department of Immunology, School of Changchun Medical College, Chang chun, 130031, Jilin Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Oncology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. Electronic address: gaoyon@hotmail.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Anatomy, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China. Electronic address: Haiyan@jlu.edu.cn.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity*; D018736:DNA Adducts / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004705:Endocytosis / Q000187:drug effects; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000473:pathology; D020714:Maximum Tolerated Dose; D008807:Mice, Inbred BALB C; D010742:Phospholipid Ethers / Q000138:chemical synthesis / Q000737:chemistry; D014018:Tissue Distribution / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: C400185:1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine; D018736:DNA Adducts; D008055:Lipids; D010742:Phospholipid Ethers; D002945:Cisplatin
keywords: Breast cancer; Cisplatin; Liposome; Nanoparticles; Nephrotoxicity