title: Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report.
abstract: The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively. The patient has suffered from hepatitis B for 30 years. His liver function deteriorated, yielding Child-Pugh grade C and reaching a model for end-stage liver disease score of 33 points within a short period; this condition was complicated with highly active variceal bleeding and coagulation system failure (PT > 100 s). The patient also presented hepatocellular carcinoma. Comprehensive treatments included effective inhibition of hepatitis B virus replication and intensive care support. Piggyback orthotopic liver transplantation was performed as the final treatment. The patient recovered uneventfully and was discharged after surgery.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Yimei
authors.initials: Y
authors.lastname: Liu
authors.forename: Tiancheng
authors.initials: T
authors.lastname: Luo
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Yingyong
authors.initials: Y
authors.lastname: Hou
authors.forename: Xizhong
authors.initials: X
authors.lastname: Shen
authors.forename: Jiyao
authors.initials: J
authors.lastname: Wang
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000998:Antiviral Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology / Q000601:surgery; D003422:Critical Care; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D000998:Antiviral Agents