title: MRI of diffuse liver disease: characteristics of acute and chronic diseases.
abstract: Diffuse liver disease, including chronic liver disease, affects tens of millions of people worldwide, and there is a growing need for diagnostic evaluation as treatments become more readily available, particularly for viral liver diseases. Magnetic resonance imaging (MRI) provides unique capabilities for noninvasive characterization of the liver tissue that rival or surpass the diagnostic utility of liver biopsies. There has been incremental improvement in the use of standardized MRI sequences, acquired before and after administration of a contrast agent, for the evaluation of diffuse liver disease and the study of the liver parenchyma and blood supply. More recent developments have led to methods for quantifying important liver metabolites, including lipids and iron, and liver fibrosis, the hallmark of chronic liver disease. Here, we review the MRI techniques and diagnostic features associated with acute and chronic liver disease.
authors.affiliation: Department of Medical Imaging University of Arizona College of Medicine, Tucson, Arizona, USA. dmartin@radiology.arizona.edu.
authors.forename: Surya
authors.initials: S
authors.lastname: Chundru
authors.forename: Bobby
authors.initials: B
authors.lastname: Kalb
authors.forename: Hina
authors.initials: H
authors.lastname: Arif-Tiwari
authors.forename: Puneet
authors.initials: P
authors.lastname: Sharma
authors.forename: James
authors.initials: J
authors.lastname: Costello
authors.forename: Diego R
authors.initials: DR
authors.lastname: Martin
mesh_terms: D000208:Acute Disease; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications; D002908:Chronic Disease; D003287:Contrast Media; D005234:Fatty Liver / Q000150:complications; D042882:Gallstones / Q000150:complications; D006519:Hepatitis, Alcoholic / Q000150:complications; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000737:chemistry / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008107:Liver Diseases / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods
chemical_list: D003287:Contrast Media