title: Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis.
abstract: This study aims to investigate associations between observed clinical parameters and known genetic risk factors of psoriasis in a well-defined prospective cohort of paediatric patients with plaque psoriasis (n = 151). Significant associations were found for paediatric-onset psoriasis with ERAP1 (p = 0.002), IL23R (p = 0.01), LCE3C_LCE3B-del (p = 0.00049) and HLA-C*06 (p = 3.15 × 10(-30)). Psoriasis severity was associated with the single nucleotide polymorphisms tagging IFIH1 and ERAP1 (p < 0.05). An onset before 10 years of age was associated with IL12B (p = 0.02). Nail psoriasis was more often seen in HLA-C*06-negative patients (p = 0.008). Remarkably, family history is clearly not associated with HLA-C*06 in this specific group. The large proportion of patients with a positive family history in HLA-C*06 negative patients (and the lack of correlation between the two) indicates that other genes, either alone or interaction between two or more genes, may have significant effects on heritability.
authors.affiliation: Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Annet M
authors.initials: AM
authors.lastname: Oostveen
authors.forename: Judith G M
authors.initials: JG
authors.lastname: Bergboer
authors.forename: Peter C M
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: Patrick L J M
authors.initials: PL
authors.lastname: Zeeuwen
authors.forename: Elke M G J
authors.initials: EM
authors.lastname: de Jong
authors.forename: Joost
authors.initials: J
authors.lastname: Schalkwijk
authors.forename: Marieke M B
authors.initials: MM
authors.lastname: Seyger
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D040941:Heredity; D006801:Humans; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010375:Pedigree; D010641:Phenotype; D011446:Prospective Studies; D011565:Psoriasis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D012042:Registries; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015236:HLA-C Antigens; C528994:HLA-C*06 antigen