title: A Phytochemical-rich Multivitamin-multimineral Supplement Is Bioavailable and Reduces Serum Oxidized Low-density Lipoprotein, Myeloperoxidase, and Plasminogen Activator Inhibitor-1 in a Four-week Pilot trial of Healthy Individuals.
abstract: BACKGROUND
  A multivitamin-multimineral supplement combined with a diverse blend of bioactive phytochemicals may provide additional antioxidant capacity and anti-inflammatory property for overall health. This convenient feature may be useful for individuals who want to increase their intake of phytochemicals.
  
  
  METHODS
  We conducted a pilot study in 15 healthy individuals (8 women and 7 men, mean age 41.7±14.9 years, mean body mass index 28.0±5.6) to investigate the effects of this novel formulation on biomarkers associated with oxidative stress and inflammation. After a 2-week diet that limited intake of fruits and vegetables to 2 servings/day, participants continued with the same restricted diet but began consuming 2 tablets of the study product for the subsequent 4 weeks. Fasting blood samples collected at Week 2 and Week 6 were analyzed and compared using paired t-tests for levels of carotenoids, folate, vitamin B12, homocysteine, oxidized low-density lipoprotein cholesterol (oxLDL), high-sensitivity C-reactive protein (hs-CRP), F2-isoprostane, plasminogen activator inhibitor-1 (PAI-1), and myeloperoxidase. Noninvasive peripheral arterial tonometry (EndoPAT) was also measured.
  
  
  RESULTS
  After 4 weeks of supplementation, plasma levels of carotenoids, folate, and vitamin B12, but not homocysteine, were significantly increased (P<.05). Serum levels of oxLDL, PAI-1 and myeloperoxidase were significantly reduced (P<.05), but F2-isoprostane, hs-CRP, and EndoPAT measures were unchanged compared with baseline. The study product was well tolerated.
  
  
  CONCLUSIONS
  This nutritional supplement is bioavailable as indicated by the significant increase in plasma carotenoids, vitamin B12, and folate levels and may provide health benefits by significantly reducing serum levels of oxLDL, myeloperoxidase, and PAI-1 in healthy individuals.
authors.affiliation: Functional Medicine Research Center, Research and Development, Metagenics, Inc, Gig Harbor, Washington, United States.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lerman
authors.affiliation: Functional Medicine Research Center, Research and Development, Metagenics, Inc, Gig Harbor, Washington, United States.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Desai
authors.affiliation: Functional Medicine Research Center, Research and Development, Metagenics, Inc, Gig Harbor, Washington, United States.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Lamb
authors.affiliation: Functional Medicine Research Center, Research and Development, Metagenics, Inc, Gig Harbor, Washington, United States.
authors.forename: Jyh-Lurn
authors.initials: JL
authors.lastname: Chang
authors.affiliation: Functional Medicine Research Center, Research and Development, Metagenics, Inc, Gig Harbor, Washington, United States.
authors.forename: Gary
authors.initials: G
authors.lastname: Darland
authors.affiliation: Functional Medicine Research Center, Research and Development, Metagenics, Inc, Gig Harbor, Washington.
authors.forename: Veera R
authors.initials: VR
authors.lastname: Konda
keywords: Multivitamin; cardiovascular disease; low-density lipoprotein; multimineral