title: Antioxidant, antimelanogenic, and skin-protective effect of sesamol.
abstract: Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value < 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. Sesamol exhibited high antioxidant and anti-tyrosinase activity compared to the positive control, kojic acid and β-arbutin. Sesamol from edible sesame seed could therefore have an alternative cosmeceutical purpose.
authors.affiliation: Graduate School, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (M.S.), Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Associate Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (K.K.).
authors.forename: Montra
authors.initials: M
authors.lastname: Srisayam
authors.affiliation: Graduate School, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (M.S.), Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Associate Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (K.K.).
authors.forename: Natthida
authors.initials: N
authors.lastname: Weerapreeyakul
authors.affiliation: Graduate School, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (M.S.), Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Associate Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (K.K.).
authors.forename: Sahapat
authors.initials: S
authors.lastname: Barusrux
authors.affiliation: Graduate School, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (M.S.), Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (N.W.), Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Associate Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (S.B.), Faculty of Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand (K.K.).
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D052117:Benzodioxoles / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D006801:Humans; D008545:Melanoma / Q000188:drug therapy; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010636:Phenols / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism; D014709:Vero Cells
chemical_list: D000975:Antioxidants; D052117:Benzodioxoles; D001713:Biphenyl Compounds; D010636:Phenols; D010851:Picrates; C025583:sesamol; C004931:1,1-diphenyl-2-picrylhydrazyl; D014442:Monophenol Monooxygenase