title: The effect of in-line infusion filtering on in-line pressure monitoring in an experimental infusion system for newborns.
abstract: OBJECTIVE
  To study the effect of in-line filtering on in-line pressure measurement in a simulated infusion system.
  
  
  METHODS
  The experimental setup consisted of a syringe pump, syringe, intravenous (IV) line, and extension line. For aqueous fluids, a 0.2-μm infusion filter was used, and for lipid emulsions, a 1.2-μm filter. Infusion speed varied from 0.5 to 10.0 mL/h. First, the effect of clamping the extension line was studied on reaching alarm threshold. Second, the effect of aqueous and lipid fluids was evaluated on in-line pressure measurements.
  
  
  RESULTS
  In-line placement of an infusion filter did not prolong the time to alarm threshold after occlusion. During 24 hours of monitoring, lipid emulsions and all-in-one admixture only caused a moderate increase in in-line pressure.
  
  
  CONCLUSIONS
  Placement of an infusion filter does not have a significant effect on the in-line pressure monitoring and has no adverse effect on detecting pressure-related complications of IV administration.
authors.forename: Tinneke
authors.initials: T
authors.lastname: Jonckers
authors.forename: Ingrid
authors.initials: I
authors.lastname: Berger
authors.forename: Twan
authors.initials: T
authors.lastname: Kuijten
authors.forename: Eduard
authors.initials: E
authors.lastname: Meijer
authors.forename: Peter
authors.initials: P
authors.lastname: Andriessen
mesh_terms: D056902:Clinical Alarms; D004867:Equipment Design; D004868:Equipment Failure; D005217:Fat Emulsions, Intravenous; D005374:Filtration / Q000295:instrumentation*; D005440:Fluid Therapy / Q000295:instrumentation* / Q000451:nursing*; D006801:Humans; D006874:Hydrostatic Pressure; D007231:Infant, Newborn; D007260:Infusion Pumps; D007363:Intensive Care Units, Neonatal; D010289:Parenteral Nutrition, Total / Q000295:instrumentation* / Q000451:nursing*; D014160:Transducers, Pressure
chemical_list: D005217:Fat Emulsions, Intravenous
keywords: clinical alarms; infusions; intravenous; newborn