title: Is chronic rhinosinusitis related to allergic rhinitis in adults and children? Applying epidemiological guidelines for causation.
abstract: The relationship between allergic rhinitis and chronic rhinosinusitis has been assessed in a number of observational and experimental studies. In this review, we attempt their synthesis and evaluation using the modified Bradford Hill guidelines for causation. Although there is no proof of causation, especially in the pediatric literature, an evaluation of underlying allergies is recommended at least as an initial measure of symptoms relief.
authors.affiliation: Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Georgalas
authors.forename: I
authors.initials: I
authors.lastname: Vlastos
authors.forename: V
authors.initials: V
authors.lastname: Picavet
authors.forename: C
authors.initials: C
authors.lastname: van Drunen
authors.forename: G
authors.initials: G
authors.lastname: Garas
authors.forename: E
authors.initials: E
authors.lastname: Prokopakis
mesh_terms: D000328:Adult; D002648:Child; D002908:Chronic Disease; D006801:Humans; D017410:Practice Guidelines as Topic; D012220:Rhinitis / Q000209:etiology*; D065631:Rhinitis, Allergic / Q000150:complications*; D012852:Sinusitis / Q000209:etiology*
keywords: Bradford-Hill criteria; allergic rhinitis; causation; chronic rhinosinusitis