title: Globoid cell leukodystrophy (Krabbe’s disease)  in a Japanese domestic cat.
abstract: A male Japanese domestic cat developed progressive limb paralysis from 4 months of age. The cat showed visual disorder, trismus and cognitive impairment and died at 9 months of age. At necropsy, significant discoloration of the white matter was observed throughout the brain and spinal cord. Histologically, severe myelin loss and gliosis were observed, especially in the internal capsule and cerebellum.In the lesions, severe infiltration of macrophages with broad cytoplasm filled with PAS-positive and nonmetachromatic granules (globoid cells) was evident. On the basis of these findings, the case was diagnosed as feline globoid cell leukodystrophy (Krabbe’s disease). Immunohistochemical observation indicated the involvement of oxidative stress and small HSP in the disease.
authors.forename: Mizue
authors.initials: M
authors.lastname: Ogawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Kyoko
authors.initials: K
authors.lastname: Isobe
authors.forename: Miyoko
authors.initials: M
authors.lastname: Saito
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Harada
authors.forename: James K
authors.initials: JK
authors.lastname: Chambers
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D001917:Brachial Plexus / Q000473:pathology; D001921:Brain / Q000473:pathology; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D007150:Immunohistochemistry; D007965:Leukodystrophy, Globoid Cell / Q000473:pathology* / Q000662:veterinary*; D008264:Macrophages / Q000473:pathology; D008297:Male; D009186:Myelin Sheath / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology