title: Quantitative diagnosis of colorectal polyps by spectral domain optical coherence tomography.
abstract: The principal aim of this study is to investigate the scattering coefficient of colorectal polyp tissues using an optical coherence tomography (OCT) technique. It combines the existing scattering coefficient model and spectral domain OCT to achieve method of early diagnosis of colorectal polyp in hospitals. Seventeen patients were studied, and a total of 1456 data points were extracted by curve-fitting the OCT signals into a confocal single-backscattering model. The results show that the mean scattering coefficient value for colorectal polyps is 1.91 mm(-1) (std: ± 0.54 mm(-1)), which is between the values for normal and malignant tissues. In addition, we studied the difference between adenomatous polyps (n = 15) and inflammatory polyps (n = 2) quantitatively and found that the adenomatous tissues had lower scattering coefficients than the inflammatory ones. The quantitative measurements confirmed that OCT can be used in primary diagnosis to compensate for the deficiencies in methods of pathological diagnosis, with a great potential for early diagnosis of tissues.
authors.affiliation: Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Tianjin Union Medicine Centre, Tianjin 300121, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Tianjin Union Medicine Centre, Tianjin 300121, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Tang
authors.affiliation: Tianjin Union Medicine Centre, Tianjin 300121, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Tianjin Union Medicine Centre, Tianjin 300121, China.
authors.forename: S W
authors.initials: SW
authors.lastname: Zhu
authors.affiliation: Department of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA.
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Gao
authors.affiliation: Institute of Micro & Nano Optics, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: X-C
authors.initials: XC
authors.lastname: Yuan
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003111:Colonic Polyps / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000473:pathology*; D041623:Tomography, Optical Coherence; D055815:Young Adult