title: Prevalence and predictors of anaemia in patients with HIV infection at the initiation of combined antiretroviral therapy in Xinjiang, China.
abstract: We retrospectively analysed routinely collected baseline data of 2252 patients with HIV infection registered in the National Free Antiretroviral Treatment Program in Xinjiang province, China, from 2006 to 2011 to estimate the prevalence and predictors of anaemia at the initiation of combined antiretroviral therapy. Anaemia was diagnosed using the criteria set forth by the World Health Organisation, and univariate and multivariate logistic regression analyses were performed to determine its predictors. The prevalences of mild, moderate, and severe anaemia at the initiation of combined antiretroviral therapy were 19.2%, 17.1%, and 2.6%, respectively. Overall, 38.9% of the patients were anaemic at the initiation of combined antiretroviral therapy. The multivariate logistic regression analysis indicated that Uyghur ethnicity, female gender, lower CD4 count, lower body mass index value, self-reported tuberculosis infection, and oral candidiasis were associated with a higher prevalence of anaemia, whereas higher serum alanine aminotransferase level was associated with a lower prevalence of anaemia. The results suggest that the overall prevalence of anaemia at the initiation of combined antiretroviral therapy in patients with HIV infection is high in Xinjiang, China, but severe anaemia is uncommon. Patients in China should be routinely checked for anaemia prior to combined antiretroviral therapy initiation, and healthcare providers should carefully select the appropriate first-line combined antiretroviral therapy regimens for anaemic patients.
authors.affiliation: Department of Epidemiology and Biostatistics, Xinjiang Medical University, Urumqi, China.
authors.forename: Peierdun
authors.initials: P
authors.lastname: Mijiti
authors.affiliation: Department of Infectious Disease, Xinjiang Medical University First Affiliated Hospital, Urumqi, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yuexin
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Min
authors.affiliation: Department of Infectious Disease, Xinjiang Medical University First Affiliated Hospital, Urumqi, China.
authors.forename: Maimaitili
authors.initials: M
authors.lastname: Wubuli
authors.affiliation: Department of Infectious Disease, Xinjiang Medical University First Affiliated Hospital, Urumqi, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Kejun
authors.affiliation: Xinjiang Medical University, Urumqi, China halmurat@263.net.
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000453:epidemiology* / Q000209:etiology*; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: AIDS; China; HIV; anaemia; antiretroviral therapy; haemoglobin; predictors; prevalence