title: Microfluidic systems with ion-selective membranes.
abstract: When integrated into microfluidic chips, ion-selective nanoporous polymer and solid-state membranes can be used for on-chip pumping, pH actuation, analyte concentration, molecular separation, reactive mixing, and molecular sensing. They offer numerous functionalities and are hence superior to paper-based devices for point-of-care biochips, with only slightly more investment in fabrication and material costs required. In this review, we first discuss the fundamentals of several nonequilibrium ion current phenomena associated with ion-selective membranes, many of them revealed by studies with fabricated single nanochannels/nanopores. We then focus on how the plethora of phenomena has been applied for transport, separation, concentration, and detection of biomolecules on biochips.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556; email: zslouka@nd.edu , ssenapat@nd.edu , hchang@nd.edu.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Slouka
authors.forename: Satyajyoti
authors.initials: S
authors.lastname: Senapati
authors.forename: Hsueh-Chia
authors.initials: HC
authors.lastname: Chang
mesh_terms: D000818:Animals; D006801:Humans; D007477:Ions; D008566:Membranes / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D058608:Nanopores; D011108:Polymers / Q000737:chemistry
chemical_list: D007477:Ions; D011108:Polymers
keywords: biosensing; depletion; electrokinetics; limiting current; molecular concentration