title: Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers.
abstract: Food plants provide important phytochemicals which help improve or maintain health through various biological activities, including antioxidant effects. Cigarette smoke-induced oxidative stress leads to the formation of lipid hydroperoxides (LOOHs) and their decomposition product malondialdehyde (MDA), both of which cause oxidative damage to DNA. Two hundred forty-five heavy cigarette smokers completed a randomized, double-blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on LOOH- and MDA-DNA adducts in peripheral blood lymphocytes (PBLs). Volunteers drank noni juice or a fruit juice placebo every day for 1 month. DNA adducts were measured by (32)P postlabeling analysis. Drinking 29.5-118 mL of noni juice significantly reduced adducts by 44.6-57.4%. The placebo, which was devoid of iridoid glycosides, did not significantly influence LOOH- and MDA-DNA adduct levels in current smokers. Noni juice was able to mitigate oxidative damage of DNA in current heavy smokers, an activity associated with the presence of iridoids.
authors.affiliation: Department of Pathology, University of Illinois College of Medicine at Rockford 1601 Parkview Avenue, Rockford, Illinois.
authors.forename: Mian-Ying
authors.initials: MY
authors.lastname: Wang
authors.affiliation: Department of Pathology, University of Illinois College of Medicine at Rockford 1601 Parkview Avenue, Rockford, Illinois.
authors.forename: Lin
authors.initials: L
authors.lastname: Peng
authors.affiliation: Research and Development, Morinda, Inc. 737 East 1180 South, American Fork, Utah.
authors.forename: Claude J
authors.initials: CJ
authors.lastname: Jensen
authors.affiliation: Research and Development, Morinda, Inc. 737 East 1180 South, American Fork, Utah.
authors.forename: Shixin
authors.initials: S
authors.lastname: Deng
authors.affiliation: Research and Development, Morinda, Inc. 737 East 1180 South, American Fork, Utah.
authors.forename: Brett J
authors.initials: BJ
authors.lastname: West
keywords: Antioxidant; DNA adducts; Morinda citrifolia; noni