title: [Cognitive impairment in earthquake brain injury treated with comprehensive program of acupuncture and rehabilitation: a randomized controlled trial].
abstract: OBJECTIVE
  To explore the comprehensive program of integrated Chinese and western medicine in the treatment of cognitive impairment in earthquake brain injury.
  
  
  METHODS
  The multi-central randomized controlled trial was adopted. The qualified subjects were randomized into an acupuncture + rehabilitation group (38 cases) and a rehabilitation group (35 cases). In the acupuncture + rehabilitation group, acupuncture, hyperbaric oxygen (HBO) and cognitive rehabilitation training were combined as the comprehensive program of integrated Chinese and western medicine in the treatment. In the rehabilitation group, HBO and cognitive rehabilitation training were adopted. The efficacy and safety were assessed.
  
  
  RESULTS
  (1) After treatment of 2 months, the intelligent state, cognitive function and activity of daily life of patients were improved in the both groups (all P < 0.01). (2) After treatment of 2 months, the score of MMSE and the score of activity of daily life were (24.11 +/- 4.08) and (75.45 +/- 13.95) in the acupuncture + rehabilitation group, which were more significant as compared with (17.05 +/- 43.84), (66.06 +/- 12.75) in the rehabilitation group, respectively (both P < 0.01). In 6-month follow-up visit after treatment, the cognitive function and activity of daily life were improved continuously in the acupuncture + rehabilitation group, which was more significant as compared with the rehabilitation group (P < 0.01, P < 0.05).
  
  
  CONCLUSIONS
  The integrated Chinese and western medicine of acupuncture, HBO and cognitive rehabilitation training is safe and effective in the treatment of cognitive impairment in earthquake brain injury. The therapeutic effect is more advantageous as compared with the simple rehabilitation program of western medicine.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhou
authors.forename: An-Ren
authors.initials: AR
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Qiu
authors.forename: Shu
authors.initials: S
authors.lastname: Huang
authors.forename: Wen-Chun
authors.initials: WC
authors.lastname: Wang
authors.forename: Yong-He
authors.initials: YH
authors.lastname: Hu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Xie
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Zhai
authors.forename: Yue
authors.initials: Y
authors.lastname: Jiang
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Zheng
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000203:Activities of Daily Living; D015670:Acupuncture Therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000523:psychology / Q000534:rehabilitation / Q000628:therapy*; D003071:Cognition; D055866:Earthquakes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult