title: Response to letter to the editor by Dr Wages et al.
authors.affiliation: Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan. hirakawa@med.nagoya-u.ac.jp.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirakawa
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Matsui
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D006801:Humans; D020714:Maximum Tolerated Dose; D015233:Models, Statistical