title: Coadministration of a Na+-H+ exchange inhibitor and sodium bicarbonate for the treatment of asphyxia-induced cardiac arrest in piglets.
abstract: BACKGROUND
  The present study tested the hypothesis that addition of an inhibitor of Na(+)/H(+) exchanger (NHE1) to sodium bicarbonate might improve the response to base therapy from prolonged asphyxial cardiac arrest in piglets.
  
  
  METHODS
  Asphyxial cardiac arrest was induced by endotracheal tube clamping. Animals were randomly assigned to four study groups: (i) vehicle control, (ii) administration of sabiporide (NHE1 inhibitor), (iii) administration of sodium bicarbonate, and (iv) administration of sabiporide and sodium bicarbonate.
  
  
  RESULTS
  Administration of sodium bicarbonate alone did not affect survival, hemodynamic measures, and regional blood flow to critical tissues such as brain, heart, kidney, liver, and spleen. In contrast, sabiporide given alone or combined with sodium bicarbonate improved these. Furthermore, treatment with sabiporide reduced accumulation of neutrophils, reduced cytokine production in the lung, and reduced plasma levels of cardiac troponin-I, alanine aminotransferase, aspartate aminotransferase, and urea. In addition, the combined use of sabiporide and sodium bicarbonate had more profound reduction in interleukin (IL)-6 and IL-10, compared to sabiporide alone.
  
  
  CONCLUSIONS
  These results suggest that addition of sabiporide to the administration of sodium bicarbonate might improve hemodynamic response and dampen the inflammatory cascade noted with cardiac arrest, and therefore being an attractive option in the treatment of cardiac arrest.
authors.affiliation: Department of Research, Mount Sinai Medical Center, Miami Beach, Florida.
authors.forename: Xinchun
authors.initials: X
authors.lastname: Lin
authors.affiliation: 1] Medical and Research Services and Division of Nephrology, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California [2] David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kraut
authors.affiliation: 1] Department of Research, Mount Sinai Medical Center, Miami Beach, Florida [2] Department of Biotechnology, Information Science, and Nanotechnology (BIN) Fusion Technology, Chonbuk National University, Jeonju, Korea.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001237:Asphyxia / Q000150:complications*; D016207:Cytokines / Q000378:metabolism; D004452:Echocardiography; D006146:Guanidines / Q000494:pharmacology*; D006323:Heart Arrest / Q000188:drug therapy* / Q000209:etiology*; D006439:Hemodynamics / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D017693:Sodium Bicarbonate / Q000494:pharmacology*; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors*; D013552:Swine; D019210:Troponin I / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D016207:Cytokines; D006146:Guanidines; D017923:Sodium-Hydrogen Exchangers; D019210:Troponin I; D017693:Sodium Bicarbonate; D014508:Urea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C476560:sabiporide