title: IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia.
abstract: OBJECTIVE
  Recent studies have suggested that Th17 cells may play a role in the pathogenesis of acute myeloid leukemia (AML). This subset of CD4+ cells is characterized by interleukin (IL)-17A and IL-17F production, which share strong homology, and surface expression of the IL-23 receptor (IL-23R). The present study aimed to determine the association between the polymorphic features located within the IL-17A, IL-17F and IL-23R genes and disease susceptibility, progression and response to therapy. In addition, the relationship between the polymorphic variants and the plasma IL-17 levels in patients was analyzed.
  
  
  METHODS
  For this purpose, 187 individuals of Polish origin including 62 AML patients and 125 healthy controls were typed for IL-17A (rs2275913; G-197A), IL-17F (rs763780; A7488G; His161Arg) and IL-23R (rs11209026, G1142A; Arg381Gln) alleles.
  
  
  RESULTS
  The rs763780 IL-17F polymorphism appeared to be associated with susceptibility to the disease. The presence of the minor (G) variant (RR = 4.76, p < 0.001) and its homozygosity (RR = 23.02, p < 0.005) was more frequent among patients than healthy individuals. No significant association was observed for either other polymorphisms studied or IL-17 levels.
  
  
  CONCLUSIONS
  Thus, the rs763780 IL-17F polymorphism was found to be associated with predisposition to AML in the Polish population.
authors.affiliation: Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wrocław Medical University, Wybrzeże L. Pasteura 4, 50-367, Wrocław, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wróbel
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gębura
authors.forename: Barbara
authors.initials: B
authors.lastname: Wysoczańska
authors.forename: Bożena
authors.initials: B
authors.lastname: Jaźwiec
authors.forename: Olga
authors.initials: O
authors.lastname: Dobrzyńska
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kuliczkowski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bogunia-Kubik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; C515500:IL23R protein, human; D020381:Interleukin-17; D018123:Receptors, Interleukin