title: Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.
abstract: A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers.
authors.affiliation: College of Medicine, Hubei Polytechnic University, Huangshi 435003, China. cuibc928@hotmail.com.
authors.forename: Bing Cun
authors.initials: BC
authors.lastname: Cui
authors.affiliation: Photodynamic Therapy (PDT) Research Institute, School of Nano System Engineering, Inje University, Gimhae 621-749, Korea. yoonil71@inje.ac.kr.
authors.forename: Il
authors.initials: I
authors.lastname: Yoon
authors.affiliation: Photodynamic Therapy (PDT) Research Institute, School of Nano System Engineering, Inje University, Gimhae 621-749, Korea. jiazhu82@163.com.
authors.forename: Jia Zhu
authors.initials: JZ
authors.lastname: Li
authors.affiliation: Photodynamic Therapy (PDT) Research Institute, School of Nano System Engineering, Inje University, Gimhae 621-749, Korea. wlee@inje.ac.kr.
authors.forename: Woo Kyoung
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Photodynamic Therapy (PDT) Research Institute, School of Nano System Engineering, Inje University, Gimhae 621-749, Korea. ykshim@inje.ac.kr.
authors.forename: Young Key
authors.initials: YK
authors.lastname: Shim
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D017319:Photosensitizing Agents; D026082:Singlet Oxygen