title: Acute functional reactivation of the language network during awake intraoperative brain mapping.
abstract: Acute brain plasticity during resection of central lesions has been recently described. In the cases reported, perilesional latent networks, useful to preserve the neurological functions, were detected in asymptomatic patients. In this paper, we presented a case of acute functional reactivation (AFR) of the language network in a symptomatic patient. Tumor resection allowed to acutely restore the neurological deficit. Intraoperative direct cortical stimulation (DCS) and functional neuroimaging showed new epicentres of activation of the language network after tumor excision. DCS in awake surgery is mandatory to reveal AFR needful to improve the extent of resection preserving the quality of life.
authors.affiliation: a Department of Neuroscience, Division of Neurosurgery , University of Brescia , Brescia , Italy.
authors.forename: Giannantonio
authors.initials: G
authors.lastname: Spena
authors.forename: Emanuele
authors.initials: E
authors.lastname: Costi
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Panciani
authors.forename: Elena
authors.initials: E
authors.lastname: Roca
authors.forename: Karol
authors.initials: K
authors.lastname: Migliorati
authors.forename: Marco Maria
authors.initials: MM
authors.lastname: Fontanella
mesh_terms: D001921:Brain / Q000098:blood supply; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D004401:Dysarthria / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D014851:Wakefulness / Q000502:physiology*
chemical_list: D010100:Oxygen
keywords: awake surgery; brain mapping; functional MR imaging; glioma; plasticity