title: Two polycyclic geranylhydroquinone-derived metabolites from roots of Arnebia hispidissima (Lehm.) DC.
abstract: A phytochemical investigation of the least polar organic extracts of Arnebia hispidissima (Lehm.) DC. roots has led to the isolation of two unique polycyclic geranylhydroquinone-derived metabolites, arnebacene (1) and arnebidin (2), along with some known phenolic metabolites viz., arnebin-7 (3) and vanillic acid (4). The chemical identification of the new isolated compounds, including their relative stereochemistry, was achieved via spectroscopic analyses, including 2D NMR, and spectral comparison with related compounds. A biosynthetic pathway is proposed for the new compounds on the basis of their structure-relationship with previously isolated metabolites.
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University (KSU), Riyadh 11451, Kingdom of Saudi Arabia. afahmed@ksu.edu.sa.
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University (MU), Mansoura 35516, Egypt.
authors.forename: Hassan-Elrady A
authors.initials: HE
authors.lastname: Saad
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University (MU), Mansoura 35516, Egypt.
authors.forename: Eman M
authors.initials: EM
authors.lastname: Abd El-Karim
mesh_terms: D028082:Boraginaceae; D053858:Metabolic Networks and Pathways; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D011083:Polycyclic Compounds; D013729:Terpenes; C026301:geranylhydroquinone