title: Eosinophilic esophagitis: historical perspective on an evolving disease.
abstract: Initial case series describing children and adults with symptoms related to esophageal dysfunction and dense esophageal eosinophilia lead to recognition of a "new" disease, eosinophilic esophagitis (EoE). Clinical, basic, and translational studies have provided a deeper understanding of this somewhat enigmatic disease that mechanistically is defined as an antigen-driven condition limited to the esophagus. This article summarizes many of the key historical features of EoE and provides a glimpse of potential future developments.
authors.affiliation: North Tyneside Hospital, Rake Lane, North Shields NE29 8NH, UK.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Attwood
authors.affiliation: Gastrointestinal Eosinophilic Diseases Program, Children's Hospital Colorado, 13123 East 16th Avenue, B290, Aurora, CO 80045, USA. Electronic address: glenn.furuta@childrenscolorado.org.
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Furuta
mesh_terms: D057765:Eosinophilic Esophagitis / Q000175:diagnosis / Q000266:history* / Q000628:therapy; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
keywords: Dysphagia; Eosinophilic esophagitis; Eosinophilic oesophagitis; Food bolus obstruction