title: Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism.
abstract: Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.
authors.affiliation: Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain jdelpozo@unav.es.
authors.forename: J L
authors.initials: JL
authors.lastname: Del Pozo
authors.affiliation: Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Fernández-Ros
authors.affiliation: Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Sáez
authors.affiliation: Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Herrero
authors.affiliation: Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Yuste
authors.affiliation: Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of Basque Country (UPV), IKERBASQUE (Basque Foundation for Science), San Sebastián, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Banales
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D000368:Aged; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D000069349:Linezolid; D016031:Liver Transplantation; D008297:Male; D008928:Mitochondria / Q000235:genetics*; D009617:Nocardia Infections / Q000188:drug therapy; D009616:Nocardia asteroides / Q000187:drug effects; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D020641:Polymorphism, Single Nucleotide; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000081:Acetamides; D004272:DNA, Mitochondrial; D023303:Oxazolidinones; D012336:RNA, Ribosomal, 16S; D000069349:Linezolid