title: Process optimization for fabrication of gellan based electrospun nanofibers.
abstract: In this investigation, the nanofiber formation ability of gellan, a FDA approved low cost natural polysaccharide, has been achieved for the first time using electrospinning technique. The gellan based ultrafine nanofibers were fabricated by using a blend mixture of gellan with another biodegradable polymer polyvinyl alcohol (PVA). The morphology of resulting gellan-PVA nanofibers was analyzed using field emission scanning electron microscopy (FESEM). The mass ratio of 50:50 for gellan:PVA was recorded as an optimum solution ratio to obtain uniform bead free nanofibers with an average diameter of 40 ± 15.8 nm. Data depicted that among different parameters evaluated, viscosity and the mass ratio of gellan:PVA were the key parameters that influence the nanofiber morphology and diameter.
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Vashisth
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
authors.forename: Parul A
authors.initials: PA
authors.lastname: Pruthi
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
authors.forename: Rajesh P
authors.initials: RP
authors.lastname: Singh
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India. Electronic address: vikasfbs@iitr.ernet.in.
authors.forename: Vikas
authors.initials: V
authors.lastname: Pruthi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D055664:Electrochemical Techniques; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D011142:Polyvinyl Alcohol
keywords: Electrospinning; Gellan; Nanofibers; Polyvinyl alcohol