title: ICD programming to reduce shocks and improve outcomes.
abstract: Despite the clinical benefit of implantable cardioverter defibrillator (ICD), there is a high frequency of inappropriate ICD therapy associated with impaired quality of life, unwanted health care resource utilization, and adverse clinical outcome. Alternative strategies of ICD programming are needed to reduce the risk of inappropriate and "unnecessary" ICD therapies and to improve patient outcome. In this review, we provide an overview of the rate of inappropriate and appropriate ICD therapies in clinical trials and large registries as well as a review of current trials evaluating novel ICD programming to reduce inappropriate ICD therapy to avoid unnecessary ICD therapy. Based on recent studies including a large randomized trial, we recommend a simple programming approach involving high-rate device therapy beginning at 200 bpm with a 2.5 sec delay for it reduces inappropriate therapy, unnecessary therapy, and all-cause mortality in patients receiving ICD or CRT-D devices for primary prevention indications.
authors.affiliation: Heart Research Follow-Up Program, University of Rochester Medical Center, Rochester, NY, USA, valentina.kutyifa@heart.rochester.edu.
authors.forename: Valentina
authors.initials: V
authors.lastname: Kutyifa
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zareba
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Moss
mesh_terms: D001281:Atrial Fibrillation / Q000628:therapy*; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D013617:Tachycardia, Supraventricular / Q000628:therapy*; D017180:Tachycardia, Ventricular / Q000628:therapy*; D016896:Treatment Outcome; D019564:Unnecessary Procedures / Q000706:statistics & numerical data