title: Infrequent ERBB2 mutations in Chinese patients with non-small cell lung cancer.
abstract: ERBB2 mutations have been reported to occur in a subset of patients with lung adenocarcinomas or lung squamous cell carcinomas for some ethnicities, but it is unclear for Chinese patients with lung squamous cell carcinomas up to now. We retrospectively evaluated the status of ERBB2 mutations in a large cross-sectional cohort of 212 Chinese patients with non-small cell lung cancer (NSCLC) diagnosed in several hospitals from southern China during a time period of 1.5 years by polymerase chain reaction (PCR)-based direct sequencing and PCR-single strand conformation polymorphism (PCR-SSCP) analysis. ERBB2 mutation was found in 1 of 49 lung adenocarcinomas (2.0%) and none in lung squamous cell carcinomas and lung adenosquamous carcinomas. It implies the occurrence of ERBB2 mutations is infrequent in Chinese patients with NSCLC, especially in lung squamous cell carcinomas.
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Shuidong
authors.initials: S
authors.lastname: Feng
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ling
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Tong
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Guobin
authors.initials: G
authors.lastname: Hu
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liao
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Lv
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Hongzhuan
authors.initials: H
authors.lastname: Tan
authors.affiliation: 1 Basic Medical Postdoctoral Research Station, 2 Department of Epidemiology & Health Statistics, School of Public Health, 3 Department of Physiology, School of Medicine, University of South China, Hengyang 421001, China ; 4 The Pathology Department, Tumor Hospital of Hunan Province, Changsha 410008, China ; 5 Department of Epidemiology & Health Statistics, School of Public Health, Central South University, Changsha 410008, China ; 6 Department of Medical Microbiology, School of Medicine, University of South China, Hengyang 421001, China.
authors.forename: Yimou
authors.initials: Y
authors.lastname: Wu
keywords: ERBB2/HER2; molecular; mutation; non-small cell lung cancer (NSCLC)