title: Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict.
abstract: Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose tissue in renal carcinogenesis is therefore of major importance for the development of novel paradigms of RCC prevention and treatment. Here, we discuss the current knowledge on the impact of obesity on the development and progression of RCC as well as the role of adipose tissue-derived hormones (adipokines) in the conflict between growing tumors and the immune system.
authors.affiliation: Laboratoire de Génétique; Immunologie et Pathologies Humaines; Département de Biologie; Faculté des Sciences de Tunis; Campus Universitaire; Université Tunis-el Manar; El Manar-Tunis, Tunisia.
authors.forename: Asma
authors.initials: A
authors.lastname: Gati
authors.affiliation: Laboratoire de Génétique; Immunologie et Pathologies Humaines; Département de Biologie; Faculté des Sciences de Tunis; Campus Universitaire; Université Tunis-el Manar; El Manar-Tunis, Tunisia.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Kouidhi
authors.affiliation: Laboratoire de Génétique; Immunologie et Pathologies Humaines; Département de Biologie; Faculté des Sciences de Tunis; Campus Universitaire; Université Tunis-el Manar; El Manar-Tunis, Tunisia.
authors.forename: Raja
authors.initials: R
authors.lastname: Marrakchi
authors.affiliation: Laboratoire de Génétique; Immunologie et Pathologies Humaines; Département de Biologie; Faculté des Sciences de Tunis; Campus Universitaire; Université Tunis-el Manar; El Manar-Tunis, Tunisia.
authors.forename: Amel
authors.initials: A
authors.lastname: El Gaaied
authors.affiliation: Service d'histopathologie; Hôpital Charles Nicolle; Tunis, Tunisia.
authors.forename: Nadia
authors.initials: N
authors.lastname: Kourda
authors.affiliation: Service d'Urologie; Hôpital Charles Nicolle; Tunis, Tunisia.
authors.forename: Amine
authors.initials: A
authors.lastname: Derouiche
authors.affiliation: Service d'Urologie; Hôpital Charles Nicolle; Tunis, Tunisia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chebil
authors.affiliation: Institut Cochin; INSERM U1016; CNRS UMR 8104; Université Paris Descartes; Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Caignard
authors.affiliation: Institut Cochin; INSERM U1016; CNRS UMR 8104; Université Paris Descartes; Paris, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Perier
keywords: adipokines; immune response; obesity; renal cell carcinoma