title: Aging stem cells: transcriptome meets epigenome meets methylome.
abstract: Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk of leukemogenesis. In this issue of Cell Stem Cell, Sun et al. (2014) use highly purified HSCs along with an integrated genomic approach to evaluate aging-associated alterations in the epigenome and transcriptome of HSCs.
authors.affiliation: Leibniz Institute for Age Research, Fritz Lipmann Institute, D-07745 Jena, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Tümpel
authors.affiliation: Leibniz Institute for Age Research, Fritz Lipmann Institute, D-07745 Jena, Germany. Electronic address: klrudolph@fli-leibniz.de.
authors.forename: K Lenhard
authors.initials: KL
authors.lastname: Rudolph
mesh_terms: D000818:Animals; D057890:Epigenomics / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D008297:Male