title: Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis.
abstract: Interstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dose of i.v. cyclophosphamide pulse. The dose of cyclophosphamide and the timing of hemodialysis leading to efficacy and low toxicity are discussed.
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Ryo
authors.initials: R
authors.lastname: Sunaga
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ichimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Mizuho
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Zenshiro
authors.initials: Z
authors.lastname: Tamaki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Takekoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsui
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Takamoto
authors.initials: T
authors.lastname: Ohse
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D017563:Lung Diseases, Interstitial / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D006435:Renal Dialysis; D012595:Scleroderma, Systemic / Q000150:complications*
chemical_list: D018501:Antirheumatic Agents; D003520:Cyclophosphamide
keywords: hemodialysis; interstitial lung disease; intravenous cyclophosphamide pulse; scleroderma renal crisis; systemic sclerosis