title: [Tumor microenvironment: regulatory cells and immunosuppressive cytokines].
abstract: Immunosuppression is a mechanism developed by cancer cells to help them escape the immune system. Immunosuppression involves expansion of various cell types and production of a variety of cytokines. In this review, we explore the duality of three cancer induced cell populations, regulatory T lymphocytes, Th17 lymphocytes and MDSC, and also the pleiotropic effects of several cytokines induced during cancer development.
authors.affiliation: Inserm, faculté de médecine et de pharmacie de Dijon, 7, boulevard Jeanne d'Arc, Dijon, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Bruchard
authors.affiliation: Inserm, faculté de médecine et de pharmacie de Dijon, 7, boulevard Jeanne d'Arc, Dijon, France - Centre Georges François Leclerc, 1 rue du Professeur Marion, Dijon, France.
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
mesh_terms: D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines