title: [Serum levels of endothelial monocyte-activating polypeptide-II in type 2 diabetes mellitus].
abstract: Endothelial dysfunction is implicated in the pathogenesis of macrovascular complications of diabetes and atherosclerosis. Endothelial monocyte-activating polypeptide-II (EMAP-II) is a multifunctional polypeptide with proinflammatory and antiangiogenic activity. The aim of this study was to investigate the serum level of EMAP-II in obese and nonobese patients with type 2 diabetes. We found an increase of serum level of EMAP-II in obese diabetic patients compared to obese subjects without diabetes. Similar alterations were observed also in non-obese diabetic patients compared to control subjects. Moreover, it was significant elevation of serum EMAP-II in obese patients without diabetes compared to control subjects. In obese and non-obese patients with diabetes it was a significant correlation between HbAc1, blood glucose, body mass index and levels of EMAP-II, total cholesterol, LDL, HDL, triglycerides and EMAP-II. In obese non-diabetic patients it was significant correlation between BMI, triglycerides, total cholesterol and EMAP-II. The revealed change of EMAP-II serum level reflects an endothelial dysfunction in patients with type 2 diabetes. Hyperglycemia, dyslipidemia and obesity appear to be significant factors contributing to elevation of EMAP-II level.
authors.forename: L A
authors.initials: LA
authors.lastname: Mohyl'nyts'ka
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood* / Q000209:etiology; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D016601:RNA-Binding Proteins / Q000097:blood*
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D008055:Lipids; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; C077219:small inducible cytokine subfamily E, member 1