title: Wound healing and wound location in critical limb ischemia following endovascular treatment.
abstract: BACKGROUND
  The differences in wound healing according to wound location remain unclear.
  
  
  RESULTS
  Between April 2007 and October 2011, 138 patients (166 limbs) with critical limb ischemia with tissue loss were treated with endovascular treatment. On these limbs, 177 individual wounds were identified on the foot and were evaluated for wound healing rates and time to healing according to their locations. Wound locations were divided into 3 groups: group T (Toe wounds, n=112), group H (Heel wounds, n=25), and group E (Extensive wounds extending onto the fore- or mid-foot along with dorsum or plantar surfaces, n=40). The mean follow-up period was 23±19 months. At 3, 6, 9, and 12 months, wound healing rates were 51%, 64%, 75%, and 75%, respectively, in group T; 12%, 36%, 36%, and 52%, respectively, in group H; and 0%, 5%, 8%, and 13%, respectively, in group E. The median time to healing was 64 days (interquartile range 25-156 days) in group T, 168 days (interquartile range 123-316 days) in group H, and 267 days (interquartile range 177-316 days) in group E (P=0.038).
  
  
  CONCLUSIONS
  Extensive wounds extending onto the fore- or mid-foot along with dorsum or plantar surfaces were the most difficult type of wound to heal.
authors.affiliation: Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hirano
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Nakano
authors.forename: Toshiya
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Reiko
authors.initials: R
authors.lastname: Tsukahara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D014945:Wound Healing; D014947:Wounds and Injuries / Q000473:pathology / Q000503:physiopathology