title: Exploring the connectome: petascale volume visualization of microscopy data streams.
abstract: Recent advances in high-resolution microscopy let neuroscientists acquire neural-tissue volume data of extremely large sizes. However, the tremendous resolution and the high complexity of neural structures present big challenges to storage, processing, and visualization at interactive rates. A proposed system provides interactive exploration of petascale (petavoxel) volumes resulting from high-throughput electron microscopy data streams. The system can concurrently handle multiple volumes and can support the simultaneous visualization of high-resolution voxel segmentation data. Its visualization-driven design restricts most computations to a small subset of the data. It employs a multiresolution virtual-memory architecture for better scalability than previous approaches and for handling incomplete data. Researchers have employed it for a 1-teravoxel mouse cortex volume, of which several hundred axons and dendrites as well as synapses have been segmented and labeled.
authors.forename: Johanna
authors.initials: J
authors.lastname: Beyer
authors.forename: Markus
authors.initials: M
authors.lastname: Hadwiger
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Awami
authors.forename: Won-Ki
authors.initials: WK
authors.lastname: Jeong
authors.forename: Narayanan
authors.initials: N
authors.lastname: Kasthuri
authors.forename: Jeff W
authors.initials: JW
authors.lastname: Lichtman
authors.forename: Hanspeter
authors.initials: H
authors.lastname: Pfister
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D001923:Brain Chemistry; D003196:Computer Graphics; D063132:Connectome; D003628:Database Management Systems; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D051379:Mice; D008854:Microscopy, Electron; D051381:Rats