title: Increased serum levels of adiponectin in migraine.
abstract: OBJECTIVE
  Inflammatory mediators, including adipokines, have been studied in migraine pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate adiponectin (ADP) and its association with clinical parameters and psychiatric comorbidities in migraine patients compared with controls.
  
  
  METHODS
  This was a cross sectional study including migraine patients and controls. Beck depression and anxiety inventories, Headache impact test, and Allodynia symptom checklist were recorded. Adiponectin was measured by ELISA.
  
  
  RESULTS
  Sixty-eight migraine patients and sixty-five controls without headache were included. The ADP levels were significantly higher among patients with migraine (43.6±11.8 versus 36.6±9.7 ng/mL, P<0.0001). Adiponectin levels were not correlated with depression and anxiety scores, as well as with migraine severity and allodynia scores.
  
  
  CONCLUSIONS
  ADP levels were raised in migraine, independently of psychiatric comorbidities, migraine impact, and allodynia.
authors.affiliation: Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Halina
authors.initials: H
authors.lastname: Duarte
authors.affiliation: Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; Interdisciplinar Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Teixeira
authors.affiliation: Interdisciplinar Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Natália P
authors.initials: NP
authors.lastname: Rocha
authors.affiliation: Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; CHRU, Pole Neurologie, Université Lille 2, Lille, France; CAPES Foundation, Ministry of Education, Brasilia, DF, Brazil. Electronic address: contato@renandomingues.med.br.
authors.forename: Renan B
authors.initials: RB
authors.lastname: Domingues
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001007:Anxiety / Q000097:blood / Q000150:complications; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000150:complications; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; Allodynia; Anxiety; Chronic migraine; Depression; Migraine