title: The use of ADSCs as a treatment for chronic stroke.
abstract: Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagic-induced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure.
authors.affiliation: Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Tzu-Min
authors.initials: TM
authors.lastname: Chan
authors.forename: Horng-Jyh
authors.initials: HJ
authors.lastname: Harn
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Lin
authors.forename: Shao-Chih
authors.initials: SC
authors.lastname: Chiu
authors.forename: Po-Cheng
authors.initials: PC
authors.lastname: Lin
authors.forename: Hsin-I
authors.initials: HI
authors.lastname: Wang
authors.forename: Li-Ing
authors.initials: LI
authors.lastname: Ho
authors.forename: Chih-Pin
authors.initials: CP
authors.lastname: Chuu
authors.forename: Tzyy-Wen
authors.initials: TW
authors.lastname: Chiou
authors.forename: An-Cheng
authors.initials: AC
authors.lastname: Hsieh
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Chen
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Ho
authors.forename: Shinn-Zong
authors.initials: SZ
authors.lastname: Lin
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D002908:Chronic Disease; D006801:Humans; D056747:Immunomodulation; D018919:Neovascularization, Physiologic; D009414:Nerve Growth Factors / Q000378:metabolism; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D020521:Stroke / Q000628:therapy*
chemical_list: D009414:Nerve Growth Factors