title: Interest of targeting either cortical area Brodmann 9 or 46 in rTMS treatment for depression: a preliminary randomized study.
abstract: OBJECTIVE
  To assess the interest of specifically targeting Brodmann Areas (BA) 9 or 46 for rTMS treatment of depression.
  
  
  METHODS
  Patients with Treatment-Resistant Depression were randomly assigned to two treatment groups to receive either rTMS on BA 9 or on BA 46. Each patient underwent 10 sessions of 1Hz-rTMS for 2weeks. The Hamilton and Montgomery-Asberg Depression Rating Scales (HDRS, MADRS) were used under blind conditions to assess the therapeutic response (50% improvement). A Wilcoxon signed-rank test was used to compare the depression rating scales scores obtained before and after the 10 rTMS sessions for each of the two groups. The therapeutic results in the two groups were compared using the Mann-Whitney-Wilcoxon test. We also reported the effect sizes using Hedges's g.
  
  
  RESULTS
  Fifteen patients were included. Stimulation of both BA 9 (n=7) and BA 46 (n=8) led to similar therapeutic responses in the two groups (with moderate effect size), such as the mean decrease in HDRS (BA 9: p=0.015; BA 46: p=0.010) and MADRS (BA 9: p=0.042; BA 46: p=0.038) scores.
  
  
  CONCLUSIONS
  Our results do not come out in favor of one or the other BA.
  
  
  CONCLUSIONS
  Stimulation of BA 9 and BA 46 appears to be equally effective in the treatment of depression.
authors.affiliation: Department of Psychiatry and Addictology, University Hospital of Dijon, France; EA 4452, LPPM, University of Burgundy, France. Electronic address: benoit.trojak@chu-dijon.fr.
authors.forename: Benoit
authors.initials: B
authors.lastname: Trojak
authors.affiliation: Department of Psychiatry and Addictology, University Hospital of Dijon, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Meille
authors.affiliation: Clinical Research Department, University Hospital of Dijon, France.
authors.forename: Lysiane
authors.initials: L
authors.lastname: Jonval
authors.affiliation: Department of Psychiatry and Addictology, University Hospital of Dijon, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Schuffenecker
authors.affiliation: Department of Psychiatry, University Hospital of Besançon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Haffen
authors.affiliation: CSAPA University Hospital of Nancy, France; Department of Psychiatry, Centre Psychothérapique de Nancy, Laxou, France.
authors.forename: Raymund
authors.initials: R
authors.lastname: Schwan
authors.affiliation: Department of Psychiatry and Addictology, University Hospital of Dijon, France; EA 4452, LPPM, University of Burgundy, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Bonin
authors.affiliation: Department of Psychiatry and Addictology, University Hospital of Dijon, France; EA 4452, LPPM, University of Burgundy, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Chauvet-Gelinier
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex; D061218:Depressive Disorder, Treatment-Resistant / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: Brodmann; Cortical target; Depression; Dorsolateral prefrontal cortex; rTMS