title: [Genomics medicine and oncology].
abstract: Progress in genomics with, in particular, high throughput next generation sequencing is revolutionizing oncology. The impact of these techniques is seen on the one hand the identification of germline mutations that predispose to a given type of cancer, allowing for a personalized care of patients or healthy carriers and, on the other hand, the characterization of all acquired somatic mutation of the tumor cell, opening the door to personalized treatment targeting the driver oncogenes. In both cases, next generation sequencing techniques allow a global approach whereby the integrality of the genome mutations is analyzed and correlated with the clinical data. The benefits on the quality of care delivered to our patients are extremely impressive.
authors.affiliation: Département d'oncologie, CHUV Lausanne.
authors.forename: Olivier
authors.initials: O
authors.lastname: Michielin
authors.affiliation: Département d'oncologie, CHUV Lausanne.
authors.forename: George
authors.initials: G
authors.lastname: Coukos
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004252:DNA Mutational Analysis; D005544:Forecasting; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000517:prevention & control; D015894:Genome, Human / Q000235:genetics*; D018095:Germ-Line Mutation / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D009857:Oncogenes / Q000235:genetics; D057285:Precision Medicine; D013557:Switzerland
keywords: Mutations germinales; cancer héréditaires; cancer sporadiques; germinal mutations; germinale Mutationen; hereditary cancer; mutations somatiques; médecine personnalisée; personalised medicine; personalisierte Medizin; somatic mutations; somatische Mutationen; sporadic cancer; sporadischer Tumor; vererbbarer Tumor