title: Selenium-enriched probiotics improve antioxidant status, immune function, and selenoprotein gene expression of piglets raised under high ambient temperature.
abstract: This research was conducted to evaluate the effects of selenium-enriched probiotics (SP) on growth performance, antioxidant status, immune function, and selenoprotein gene expression of piglets under natural high ambient temperature in summer. Forty-eight crossbred weanling piglets randomly allocated to four groups were fed for 42 days ad libitum a basal diet without (Con, 0.16 mg Se/kg) and with supplementation of probiotics (P, 0.16 mg Se/kg), sodium selenite (SS, 0.46 mg Se/kg), and SP (0.46 mg Se/kg). From each group, three piglets were randomly selected for blood collection on days 0, 14, 28, and 42 and tissue collection on day 42. The SP improved growth performance of piglets. Both SS and SP increased blood glutathione peroxidase activity and tissue thioredoxin reductase 1 mRNA expression, with SP being higher than SS. All P, SS, and SP supplementation increased the superoxide dismutase activity (40.1, 53.0, and 64.5%), glutathione content (84.6, 104, and 165%), TCR-induced T lymphocyte proliferation (20.8, 26.4, and 50.0%), and IL-2 concentration (24.9, 27.2, and 46.2%) and decreased malondialdehyde content (25.1, 26.3, and 49.3%), respectively. The greatest effects of SP supplementation suggest that SP may serve as a better feed additive than P or SS for piglets under high-temperature environments.
authors.affiliation: Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University , Nanjing, Jiangsu 210095, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Gan
authors.forename: Xingxiang
authors.initials: X
authors.lastname: Chen
authors.forename: Shengfa F
authors.initials: SF
authors.lastname: Liao
authors.forename: Chenhui
authors.initials: C
authors.lastname: Lv
authors.forename: Fei
authors.initials: F
authors.lastname: Ren
authors.forename: Gengping
authors.initials: G
authors.lastname: Ye
authors.forename: Cuiling
authors.initials: C
authors.lastname: Pan
authors.forename: Da
authors.initials: D
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Xiuli
authors.initials: X
authors.lastname: Shi
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.forename: Kehe
authors.initials: K
authors.lastname: Huang
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007107:Immune System; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019936:Probiotics / Q000032:analysis / Q000378:metabolism*; D012643:Selenium / Q000032:analysis* / Q000378:metabolism; D051140:Selenoproteins / Q000235:genetics* / Q000378:metabolism; D013552:Swine / Q000235:genetics / Q000254:growth & development / Q000276:immunology / Q000378:metabolism*; D013696:Temperature
chemical_list: D000975:Antioxidants; D051140:Selenoproteins; D008315:Malondialdehyde; D005978:Glutathione; D012643:Selenium