title: [Absolute bioavailability of caffeic acid in rats and its intestinal absorption properties].
abstract: OBJECTIVE
  To investigate the absolute bioavailability of caffeic acid in rats and its intestinal absorption properties.
  
  
  METHODS
  The absolute bioavailability (Fabs) of caffeic acid was obtained after iv (2 mg x kg(-1)) or ig (10 mg x kg(-1)) administration to rats. The intestinal absorption of caffeic acid was explored by the recirculating vascularly perfused rat intestinal preparation. Caco-2 cell model was applied to measure the permeability of caffeic acid from apical to basolateral said (A-B) and from basolateral to apical said (B-A).
  
  
  RESULTS
  A two-compartment pharmacokinetic model was best to describe the pharmacokinetics of caffeic acid following iv or ig administration. The Fabs of caffeic acid was 14. 7% , and its intestinal absorption was 12.4%. The values of Papp A-->B and Papp B-->A of caffeic acid were retained stable while its concentration was changed. The efflux ratio values in this study surveyed were above 2.0, and suggesting caffeic acid was active transport.
  
  
  CONCLUSIONS
  Caffeic acid was shown to have poor permeability across the Caco-2 cells, low intestinal absorption and low oral bioavailability in rats.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.forename: Su-Jun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Ben-Kun
authors.initials: BK
authors.lastname: Yang
authors.forename: Yun-Ming
authors.initials: YM
authors.lastname: Zhong
authors.forename: Lin-Quan
authors.initials: LQ
authors.lastname: Zang
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Wang
mesh_terms: D000818:Animals; D001682:Biological Availability; D018938:Caco-2 Cells; D002109:Caffeic Acids / Q000378:metabolism / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002109:Caffeic Acids; C040048:caffeic acid