title: Glutamate supply positively affects serum cholesterol concentrations without increases in total protein and urea around the onset of puberty in goats.
abstract: Different neurotransmitter and neuromodulatory systems regulate synthesis and secretion of GnRH. Whereas the endocrine and neural systems are activated in response to the metabolic status and the circulating levels of specific blood metabolites, glutamate receptors have been reported at hepatic level. This study evaluated the possible effect of glutamate supplementation upon changes in serum concentrations across time for total protein (TP), urea (UR) and cholesterol (CL) around the onset of puberty in goats. Prepuberal female goats (n=18) were randomly assigned to: (1) excitatory amino acids group, GLUT, n=10; 16.52±1.04kg live weight (LW), 3.4±0.12 body condition score (BCS) receiving an i.v. infusion of 7mgkg(-1) LW of l-glutamate, and (2) Control group, CONT, n=8; 16.1±1.04kg LW, 3.1±0.12 BCS. General averages for LW (23.2±0.72kg), BCS (3.37±0.10 units), serum TP (65.28±2.46mgdL(-1)), UR (23.42±0.95mgdL(-1)), CL (77.89±1.10mgdL(-1)) as well as the serum levels for TP and UR across time did not differ (P>0.05) between treatments. However, while GLUT positively affected (P<0.05) both the onset (207±9 vs. 225±12 d) and the percentage (70 vs. 25%) of females showing puberty, a treatment×time interaction effect (P<0.05) was observed in the GLUT group, with increases in serum cholesterol, coincident with the onset of puberty. Therefore, in peripuberal glutamate supplemented goats, serum cholesterol profile could act as a metabolic modulator for the establishment of puberty, denoting also a potential role of glutamate as modulator of lipid metabolism.
authors.affiliation: Universidad Autónoma Chapingo, Unidad Regional Universitaria de Zonas Áridas, A.P. No. 8, Bermejillo, Durango, 35230, Mexico. Electronic address: cmeza2020@hotmail.com.
authors.forename: C A
authors.initials: CA
authors.lastname: Meza-Herrera
authors.affiliation: Universidad Autónoma Chapingo, Unidad Regional Universitaria de Zonas Áridas, A.P. No. 8, Bermejillo, Durango, 35230, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Calderón-Leyva
authors.affiliation: Universidad Autónoma Chapingo, Unidad Regional Universitaria de Zonas Áridas, A.P. No. 8, Bermejillo, Durango, 35230, Mexico.
authors.forename: M J
authors.initials: MJ
authors.lastname: Soto-Sanchez
authors.affiliation: Universidad de Córdoba, Departamento de Producción Animal, Campus de Rabanales, Ctra. Madrid-Cádiz, km 396, Córdoba, 14071, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Serradilla
authors.affiliation: Universidad de Córdoba, Departamento de Producción Animal, Campus de Rabanales, Ctra. Madrid-Cádiz, km 396, Córdoba, 14071, Spain.
authors.forename: A
authors.initials: A
authors.lastname: García-Martinez
authors.affiliation: Universidad Autónoma Agraria Antonio Narro, Periférico Raúl López Sánchez & Carretera a Santa Fe, Torreón, Coahuila, 27054, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Mellado
authors.affiliation: Universidad Autónoma Agraria Antonio Narro, Periférico Raúl López Sánchez & Carretera a Santa Fe, Torreón, Coahuila, 27054, Mexico.
authors.forename: F G
authors.initials: FG
authors.lastname: Veliz-Deras
mesh_terms: D000367:Age Factors; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001798:Blood Proteins / Q000032:analysis* / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D019587:Dietary Supplements; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology*; D006041:Goats / Q000097:blood; D012741:Sexual Maturation / Q000187:drug effects*; D014508:Urea / Q000097:blood*
chemical_list: D001798:Blood Proteins; D018698:Glutamic Acid; D014508:Urea; D002784:Cholesterol
keywords: Blood metabolites; Cholesterol; Glutamate supplementation; Goats; Puberty