title: Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury.
abstract: Mangiferin has been extensively applied in different fields due to its anti-inflammatory properties. However, the precise mechanism used by mangiferin on lipopolysaccharide (LPS)-induced inflammation has not been elucidated. Here, we discuss the potential mechanism of mangiferin during a LPS-induced brain injury. Brain injury was induced in ICR mice via intraperitoneal LPS injection (5 mg/kg). Open- and closed-field tests were used to detect the behaviors of mice, while immunoblotting was performed to measure the expression of interleukin-6 (IL-6) and cystathionine-b-synthase (CBS) in the hippocampus after mangiferin was orally administered (p.o.). Mangiferin relieved LPS-induced sickness 6 and 24 h after LPS injection; in addition, this compound suppressed LPS-induced IL-6 production after 24 h of LPS induction as well as the downregulation of LPS-induced CBS expression after 6 and 24 h of LPS treatment in the hippocampus. Therefore, mangiferin attenuated sickness behavior by regulating the expression of IL-6 and CBS.
authors.affiliation: Research Center for Neurobiology, Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu, 221004, People's Republic of China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Fu
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Liu
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Zhao
authors.forename: Xiang-Ru
authors.initials: XR
authors.lastname: Wen
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Da-Shi
authors.initials: DS
authors.lastname: Qi
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Dong
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Liu
authors.forename: Yuan-Jian
authors.initials: YJ
authors.lastname: Song
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D003541:Cystathionine beta-Synthase / Q000037:antagonists & inhibitors / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D044004:Xanthones / Q000494:pharmacology / Q000627:therapeutic use*; D000093242:Interleukin-6 Inhibitors
chemical_list: D003541:Cystathionine beta-Synthase; D015850:Interleukin-6; D008070:Lipopolysaccharides; D044004:Xanthones; D000093242:Interleukin-6 Inhibitors; C013592:mangiferin