title: The tobacco genome sequence and its comparison with those of tomato and potato.
abstract: The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ancestors and microsynteny with other Solanaceae species. We identify over 90,000 gene models and determine the ancestral origin of tobacco mosaic virus and potyvirus disease resistance in tobacco. We anticipate that the draft genomes will strengthen the use of N. tabacum as a versatile model organism for functional genomics and biotechnology applications.
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sierro
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: James N D
authors.initials: JN
authors.lastname: Battey
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Sonia
authors.initials: S
authors.lastname: Ouadi
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bakaher
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Lucien
authors.initials: L
authors.lastname: Bovet
authors.affiliation: 1] Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland [2].
authors.forename: Adrian
authors.initials: A
authors.lastname: Willig
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Simon
authors.initials: S
authors.lastname: Goepfert
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Manuel C
authors.initials: MC
authors.lastname: Peitsch
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchatel, Switzerland.
authors.forename: Nikolai V
authors.initials: NV
authors.lastname: Ivanov
mesh_terms: D001483:Base Sequence; D018744:DNA, Plant / Q000235:genetics; D060467:Disease Resistance / Q000235:genetics* / Q000276:immunology; D020869:Gene Expression Profiling; D008040:Genetic Linkage; D018745:Genome, Plant; D018551:Solanum lycopersicum / Q000235:genetics*; D010935:Plant Diseases / Q000276:immunology* / Q000821:virology; D018515:Plant Leaves / Q000235:genetics; D018517:Plant Roots / Q000235:genetics; D017800:Potyvirus / Q000472:pathogenicity; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D011198:Solanum tuberosum / Q000235:genetics*; D014026:Nicotiana / Q000145:classification / Q000235:genetics*; D014027:Tobacco Mosaic Virus / Q000472:pathogenicity
chemical_list: D018744:DNA, Plant