title: [Role of local radiotherapy after prostatectomy].
abstract: Different risk factors of biochemical relapse after prostatectomy have been identified: extra-capsular extension, seminal vesicle invasion and/or involved surgical margin. There is enough evidence in the literature that post-operative adjuvant radiation therapy can improve five and ten years local control rate, disease free survival and metastasis-free survival. Nevertheless, radiotherapy treatment is linked to a low risk of low grade toxicity and only 20-40% of biochemical relapse are observed after prostatectomy even if there is one involved surgical margin. So, it could be reasonable to propose a close monitoring of the PSA ("Prostate Specific Antigen") and adjuvant radiotherapy once the PSA is superior to 0 ng/ml. Rising PSA superior to 0.2 ng/ml after radical prostatectomy, corresponding to biochemical recurrence, is defined as a local relapse when the biochemical relapse is late and the PSA doubling time is superior to 6 months. Then, salvage radiotherapy is effective and has to be proposed taking the age of the patient, his comorbidities and his desires in consideration.
authors.forename: J
authors.initials: J
authors.lastname: Hermesse
authors.forename: X
authors.initials: X
authors.lastname: Werenne
authors.forename: S
authors.initials: S
authors.lastname: Philippi
authors.forename: P
authors.initials: P
authors.lastname: Coucke
mesh_terms: D000367:Age Factors; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000379:methods; D016879:Salvage Therapy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen