title: mitoNEET as a novel drug target for mitochondrial dysfunction.
abstract: Mitochondrial dysfunction plays an important part in the pathology of several diseases, including Alzheimer's disease and Parkinson's disease. Targeting mitochondrial proteins shows promise in treating and attenuating the neurodegeneration seen in these diseases, especially considering their complex and pleiotropic origins. Recently, the mitochondrial protein mitoNEET [also referred to as CDGSH iron sulfur domain 1 (CISD1)] has emerged as the mitochondrial target of thiazolidinedione drugs such as the antidiabetic pioglitazone. In this review, we evaluate the current understanding regarding how mitoNEET regulates cellular bioenergetics as well as the structural requirements for drug compound association with mitoNEET. With a clear understanding of mitoNEET function, it might be possible to develop therapeutic agents useful in several different diseases including neurodegeneration, breast cancer, diabetes and inflammation.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address: wgeldenh@neomed.edu.
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Geldenhuys
authors.affiliation: Department of Chemistry, University of Akron, Akron, OH, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Leeper
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Carroll
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: C525595:CISD1 protein, human; D024101:Mitochondrial Proteins; D045162:Thiazolidinediones