title: Gellan co-polysaccharide micellar solution of budesonide for allergic anti-rhinitis: an in vitro appraisal.
abstract: The aim of this study was to design a novel amphiphilic co-polysaccharide for the development of anti-rhinitis micellar solution of budesonide. Herein, a long alkyl chain (C18) was successfully grafted onto gellan polysaccharide by etherification reaction. The dispersion of co-polysaccharide in water led to formation of spherical, nanomicellar structures. Depending upon the co-polysaccharide:drug weight ratio (1:1, 1:2 and 1:3), a maximum drug loading (>95%) was noted at the lowest level. The nanomicelles were in the range of 371-750nm and showed negative zeta potential (-48.3 to -67.2mV) values indicating their stability in aqueous system. They exhibited a longer dissolution profile in simulated nasal fluid (pH 5.5). The dissolution efficiency (39.79±0.93%) was maximal at the lowest polymer: drug ratio in 6h. The drug release was found to follow first order kinetic model. Korsmeyer-peppas modeling of in vitro drug release data indicated that besides simple diffusion, no other physical phenomenon was involved in the event of drug release from the nanostructures. Differential scanning calorimetry analysis suggested some degree of physical incompatibility; however Infrared spectroscopy revealed chemical compatibility between drug and co-polysaccharide. Thus, the co-polysaccharide micellar system offers a splendid outlook in controlled intranasal delivery of budesonide for the symptomatic relief of anti-rhinitis.
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India. Electronic address: sabya245@rediffmail.com.
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Maiti
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Chakravorty
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Chowdhury
mesh_terms: D019819:Budesonide / Q000494:pharmacology / Q000627:therapeutic use*; D002152:Calorimetry, Differential Scanning; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008823:Micelles; D008970:Molecular Weight; D011135:Polysaccharides, Bacterial / Q000494:pharmacology / Q000627:therapeutic use*; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D008823:Micelles; D011135:Polysaccharides, Bacterial; D012996:Solutions; D019819:Budesonide; C048288:gellan gum
keywords: Anti-rhinitis; Budesonide; Dissolution efficiency; Gellan polysaccharide; Polysaccharide micelles; Sorbitan monooleate