title: [A long-term follow-up of the correlation between obstructive sleep apnea hypopnea syndrome and multiple organ diseases].
abstract: OBJECTIVE
  To explore the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and multiple organ diseases.
  
  
  METHODS
  Home-visit questionnaires were performed in 1 868 subjects (956 male, 912 female) with an average age of (79 ± 5) years, and a prospective follow-up was performed for a period of 20 years with annual medical examinations. Multiple organ diseases included hypertension, coronary heart disease, stroke, diabetes, pulmonary heart disease, renal insufficiency and erythrocytosis. The subjects were grouped by the diagnosis of OSAHS.
  
  
  RESULTS
  Among the 1 868 subjects, 598 (32.0%) were diagnosed with OSAHS, and 1 270 (68.0%) of non-OSAHS as the control group. By the end of follow-up, in the OSAHS group there were 477 (79.8%) cases with hypertension, 337 (56.4%) cases with coronary heart disease, 167 (27.9%) cases with stroke, 76 (12.7%) cases with diabetes, 37 (6.2%) cases with pulmonary heart disease, 73 (12.2%) cases with renal insufficiency and 211(35.3%) cases with erythrocytosis, all of which were significantly higher than those of the control group [323(25.4%), 315 (24.8%), 95 (7.5%), 69 (5.4%), 40 (3.2%), 58 (4.6%), 30 (2.4%), P < 0.01]. The number of diseases in the OSAHS group was also higher than that in the control group (P < 0.05) .
  
  
  CONCLUSIONS
  The incidence of multiple organ diseases was remarkably higher in the OSAHS group than that in the control group, which indicated that OSAHS was a risk factor for multiple organ diseases. These diseases in OSAHS patients may be related to hypoxia caused by OSAHS, endocrine and metabolic disorders, unhealthy lifestyles and arteriosclerosis.
authors.affiliation: Department of Medical Health Protection, PLA General Hospital, Jinan 250031, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Medical Health Protection, PLA General Hospital, Jinan 250031, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Dai
authors.affiliation: Department of Medical Health Protection, PLA General Hospital, Jinan 250031, China.
authors.forename: Jingquan
authors.initials: J
authors.lastname: Ni
authors.affiliation: Department of Medical Health Protection, PLA General Hospital, Jinan 250031, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhu
authors.affiliation: Department of Medical Health Protection, PLA General Hospital, Jinan 250031, China.
authors.forename: Yujian
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Elderly Medicine, the 359th Hospital of PLA 212001,Zhenjiang, Jiangsu, China. Email: cishuping@sohu.com.
authors.forename: Shuping
authors.initials: S
authors.lastname: Ci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology*; D012913:Snoring / Q000150:complications / Q000503:physiopathology