title: [Treatment of pituitary adenomas invading cavernous sinus with neuroendoscopy assisted by multiple techniques].
abstract: OBJECTIVE
  To study the effectiveness of treating giant pituitary adenomas invading cavernous sinus with neuroendoscopy assisted by multiple techniques.
  
  
  METHODS
  A total of 72 patients who underwent neuroendoscopic surgery and 55 patients who underwent microscopic surgery for giant pituitary adenomas were enrolled in this retrospective analysis. Both groups received expanded endoscopic endonasal transsphenoidal approach, intraoperative application of navigation, and Doppler.The clinical data of two groups were compared.
  
  
  RESULTS
  The two groups were significantly different in total tumor removal rate, operation time, postoperative nasal patency, and postoperative recurrence rate (P=0.004, P=0.0003, P=0.000, and P=0.002, respectively), whereas the cerebrospinal fluid leakage, postoperative diabetes insipidus, and cranial nerve injury were not significantly different (P > 0.05).
  
  
  CONCLUSIONS
  Expanded neuroendoscopic endonasal transsphenoidal approach assisted by multiple techniques is the preferred surgical method for giant invasive pituitary adenomas invading cavernous sinus.The lateral cavernous sinus approach and the further molecular biology research will bring more options for the treatment of invasive pituitary adenomas.
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Zhen-qing
authors.initials: ZQ
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Kan
authors.initials: K
authors.lastname: Deng
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Jian-xin
authors.initials: JX
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Cong-xin
authors.initials: CX
authors.lastname: Dai
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D002426:Cavernous Sinus / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044583:Neuroendoscopy / Q000379:methods*; D010911:Pituitary Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome