title: Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke.
abstract: The aim of the study was to investigate the existence of microstructural abnormalities in the white matter of the brain in stroke patients, as well as the relationship between these microstructural abnormalities and changes in depressive symptoms over 6 months. Participants were 29 acute ischemic stroke patients and 37 healthy control subjects. Depressive symptoms were assessed in all subjects using the Hamilton Rating Scale for Depression and the Zung Self-rating Depression Scale. Whole brain voxel-based analysis was used to compare diffusion tensor imaging measures of Fractional Anisotropy (FA) between the groups. Six-month follow-up examinations were conducted. Patients showed significantly lower white matter FA values in the left and right anterior limbs of the internal capsule, and 6 months after the stroke they showed significantly increased FA values in these regions. We found a significant negative correlation between the increased ratio of the FA values and the change in depression scale scores at 6-month follow-up. Regional white matter damage may reflect abnormalities in neuroanatomical pathways related to the pathophysiology of depression.
authors.affiliation: Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan; Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: ejm86rp@yahoo.co.jp.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yasuno
authors.affiliation: Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan; Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation, Kobe, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Akihide
authors.initials: A
authors.lastname: Yamamoto
authors.affiliation: Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Katsufumi
authors.initials: K
authors.lastname: Kajimoto
authors.affiliation: Department of Neuropsychiatry, Osaka University Medical School, Suita, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kazui
authors.affiliation: Department of Brain Science, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Sekiyama
authors.affiliation: Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan.
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Matsuoka
authors.affiliation: Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kitamura
authors.affiliation: Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kiuchi
authors.affiliation: Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kosaka
authors.affiliation: Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
authors.affiliation: Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
authors.affiliation: Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nagatsuka
mesh_terms: D000368:Aged; D016880:Anisotropy; D001921:Brain / Q000002:abnormalities / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003863:Depression / Q000473:pathology* / Q000523:psychology; D056324:Diffusion Tensor Imaging / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D057566:Self Report; D020521:Stroke / Q000378:metabolism / Q000503:physiopathology*
keywords: Depression; Diffusion Tensor Imaging (DTI); Fractional Anisotropy (FA); Internal capsule; Magnetic Resonance Imaging (MRI); Stroke