title: [An evaluation of the radioprotective effect of vitamin E on the salivary glands of radioactive iodine in rats].
abstract: OBJECTIVE
  This study aims to examine the acute effect of vitamin E on salivary gland of radioactive iodine (RAI; 131I)-induced rats and to evaluate whether vitamin E have a radioprotective effect.
  
  
  METHODS
  Sixteen Wistar albino rats were used in the study. The rats were divided into two groups. The first group was administered (131)I orally and 1 ml physiological saline. The second group was administered (131)I and 1 ml vitamin E intraperitoneally. Vitamin E was started two days before the RAI therapy and continued for seven days. On the eighth day, salivary glands were removed and evaluated histopathologically.
  
  
  RESULTS
  There was no statistically significant difference between the groups. The changes in the interstitial space of all glands and in acinar epithelial cells of parotid and sublingual glands were observed in a lower number of the rats of vitamin E group, compared to the controls. Except panacinar inflammation, histopathological changes in acinar epithelial cells of the submandibular gland were noticed in a lower number of the rats of vitamin E group.
  
  
  CONCLUSIONS
  Considering the changes in the interstitial space and acinar epithelial cells in a lower number of the rats of vitamin E group, we conclude that vitamin E may have protective effects for interstitial space of all glands and acinar epithelial cells of the parotid and sublingual glands during the acute period.
authors.affiliation: Department of Otolaryngology, Ankara Training and Research Hospital, 06340 Altındağ, Ankara, Turkey. flzydgn@yahoo.com.
authors.forename: Filiz
authors.initials: F
authors.lastname: Aydoğan
authors.forename: Hasan Ikbal
authors.initials: HI
authors.lastname: Atılgan
authors.forename: Gökhan
authors.initials: G
authors.lastname: Koca
authors.forename: Nihat
authors.initials: N
authors.lastname: Yumuşak
authors.forename: Emine
authors.initials: E
authors.lastname: Aydın
authors.forename: Murat
authors.initials: M
authors.lastname: Sadıç
authors.forename: Meliha
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Salih
authors.initials: S
authors.lastname: Tuncal
authors.forename: Ethem Erdal
authors.initials: EE
authors.lastname: Samim
mesh_terms: D000818:Animals; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D010306:Parotid Gland / Q000187:drug effects / Q000473:pathology; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000187:drug effects* / Q000473:pathology; D013361:Sublingual Gland / Q000187:drug effects / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D007457:Iodine Radioisotopes; D011837:Radiation-Protective Agents; D014810:Vitamin E