title: Serpins shield tumor cells from antimetastatic brain defenses.
abstract: Serpin expression in tumors facilitates brain metastasis by blocking the effects of plasmin.
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology* / Q000556:secondary*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D015843:Serpins / Q000378:metabolism*
chemical_list: D015843:Serpins; D005341:Fibrinolysin