title: Impact of female gender on bleeding complications after transradial coronary intervention (from the Korean Transradial Coronary Intervention registry).
abstract: Besides poor clinical outcomes, female gender has been known as a high-risk factor for bleeding complications. This study aimed to investigate the impact of gender on clinical outcomes and bleeding complications after transradial coronary intervention (TRI). The Korean TRI registry is a retrospective multicenter registry with 4,890 patients who underwent percutaneous coronary intervention in 2009 at 12 centers. To compare clinical outcomes and bleeding complications between the male and female groups, we performed a propensity score matching in patients who received TRI. A total of 1,194 patients (597 in each group) were studied. The primary outcome was 1-year major adverse cardiac events, including all-cause mortality, myocardial infarction, target vessel revascularization, and stroke. The secondary outcome was major bleeding (composite of bleeding requiring transfusion of ≥2 units of packed cells or bleeding that was fatal). The proportion of major adverse cardiac events was similar between the 2 groups (6.2% vs 4.7%, p = 0.308). The female group had a greater incidence of major bleeding (0.3% vs 3.2%, p <0.001). On multivariate analysis, female gender (odds ratio [OR] 7.748, 95% confidence interval [CI] 1.767 to 13.399), age ≥75 years (OR 5.824, 95% CI 2.085 to 16.274), and chronic kidney disease (OR 7.264, 95% CI 2.369 to 12.276) were independent predictors of major bleeding. In conclusion, the female gender had a tendency for more bleeding complications than male gender after TRI without difference in the clinical outcome.
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jeoung-Sook
authors.initials: JS
authors.lastname: Shin
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Seung-Jea
authors.initials: SJ
authors.lastname: Tahk
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea. Electronic address: yhhm20@hanmail.net.
authors.forename: Hyoung-Mo
authors.initials: HM
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Myeong-Ho
authors.initials: MH
authors.lastname: Yoon
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Byoung-Joo
authors.initials: BJ
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hong-Seok
authors.initials: HS
authors.lastname: Lim
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: You-Hong
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Kyoung-Woo
authors.initials: KW
authors.lastname: Seo
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Se-Jun
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Yong-Woo
authors.initials: YW
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Yonsei University Wonju Christian Hospital, Wonju, Korea.
authors.forename: Junghan
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Department of Cardiology, Yonsei University Wonju Christian Hospital, Wonju, Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Youn
authors.affiliation: Department of Cardiology, Kangwon National University Hospital, Chuncheon, Korea.
authors.forename: Byung Ryeol
authors.initials: BR
authors.lastname: Cho
authors.affiliation: Department of Cardiology, Pusan National University Hospital, Busan, Korea.
authors.forename: Kwang Soo
authors.initials: KS
authors.lastname: Cha
authors.affiliation: Department of Cardiology, Hallym University Kandong Scared Heart Hospital, Seoul, Korea.
authors.forename: Kyoo Rok
authors.initials: KR
authors.lastname: Han
authors.affiliation: Department of cardiology, Soonchunhyang University Seoul Hospital, Seoul, Korea.
authors.forename: Min Su
authors.initials: MS
authors.lastname: Hyon
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Seung Woon
authors.initials: SW
authors.lastname: Rha
authors.affiliation: Department of Cardiology, Inje University Sanggye Paik Hospital, Goyang, Korea.
authors.forename: Byung Ok
authors.initials: BO
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
authors.forename: Won Yong
authors.initials: WY
authors.lastname: Shin
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Korea.
authors.forename: Keum Soo
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Cardiology, Ulsan University GangNeung Asan Hospital, Gangneung, Korea.
authors.forename: Sang Sig
authors.initials: SS
authors.lastname: Cheong
authors.affiliation: Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000379:methods; D015331:Cohort Studies; D016001:Confidence Intervals; D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000379:methods; D019106:Postoperative Hemorrhage / Q000175:diagnosis / Q000453:epidemiology*; D017534:Radial Artery; D012042:Registries; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D015996:Survival Rate; D016896:Treatment Outcome