title: Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications.
abstract: The metabotropic glutamate (mGlu) receptors are a group of Class C seven-transmembrane spanning/G protein-coupled receptors (7TMRs/GPCRs). These receptors are activated by glutamate, one of the standard amino acids and the major excitatory neurotransmitter. By activating G protein-dependent and non-G protein-dependent signaling pathways, mGlus modulate glutamatergic transmission both in the periphery and throughout the central nervous system. Since the discovery of the first mGlu receptor, and especially during the last decade, a great deal of progress has been made in understanding the signaling, structure, pharmacological manipulation and therapeutic indications of the 8 mGlu members.
authors.affiliation: Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, TN 37232, USA.
authors.forename: Shen
authors.initials: S
authors.lastname: Yin
authors.affiliation: Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical School, Nashville, TN 37232, USA. Electronic address: Colleen.niswender@vanderbilt.edu.
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Niswender
mesh_terms: D000494:Allosteric Regulation; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008024:Ligands; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D014150:Antipsychotic Agents; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D018094:Receptors, Metabotropic Glutamate
keywords: 7TMR; Allosteric modulation; Drug discovery; Heterodimer; Pharmacology; mGlu