title: Particle designs for the stabilization and controlled-delivery of protein drugs by biopolymers: a case study on insulin.
abstract: Natural biopolymers have attracted considerable interest for the development of delivery systems for protein drugs owing to their biocompatibility, non-toxicity, renewability and mild processing conditions. This paper offers an overview of the current status and future perspectives of particle designs using biopolymers for the stabilization and controlled-delivery of a model protein drug--insulin. We first describe the design criteria for polymeric encapsulation and subsequently classify the basic principles of particle fabrication as well as the existing particle designs for oral insulin encapsulation. The performances of these existing particle designs in terms of insulin stability and in vitro release behavior in acidic and alkaline media, as well as their in vivo performance are compared and reviewed. This review forms the basis for future works on the optimization of particle design and material formulation for the development of an improved oral delivery system for protein drugs.
authors.affiliation: Chemical Engineering Discipline, School of Engineering, Monash University, Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor, Malaysia. Electronic address: lim.hui.peng@monash.edu.
authors.forename: Hui-Peng
authors.initials: HP
authors.lastname: Lim
authors.affiliation: Chemical Engineering Discipline, School of Engineering, Monash University, Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor, Malaysia; Multidisciplinary Platform of Advanced Engineering, Monash University, Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor, Malaysia. Electronic address: tey.beng.ti@monash.edu.
authors.forename: Beng-Ti
authors.initials: BT
authors.lastname: Tey
authors.affiliation: Chemical Engineering Discipline, School of Engineering, Monash University, Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor, Malaysia; Multidisciplinary Platform of Advanced Engineering, Monash University, Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor, Malaysia. Electronic address: chan.eng.seng@monash.edu.
authors.forename: Eng-Seng
authors.initials: ES
authors.lastname: Chan
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D004355:Drug Stability; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D001704:Biopolymers; D003692:Delayed-Action Preparations; D020100:Hydrogels; D007328:Insulin; D011506:Proteins
keywords: Biopolymer; Encapsulation; Insulin; Oral delivery; Protein drug