title: Eosinophilic esophagitis: overview of clinical management.
abstract: A validated disease-specific symptom-assessment tool for eosinophilic esophagitis (EoE) has yet to be approved by regulatory authorities for use in clinical trials. Relevant end points for daily practice include EoE-related symptoms and esophageal eosinophilic inflammation. Endoscopic features should also be taken into account when establishing a therapy plan. A reasonable clinical goal is to achieve a reduction in EoE-related symptoms and esophageal eosinophilic inflammation. Evidence is increasing to support an anti-inflammatory maintenance therapy, as this can reduce esophageal remodeling. In EoE patients in clinical remission, annual disease monitoring with symptom, endoscopic, and histologic assessments of sustained treatment response is recommended.
authors.affiliation: Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois/CHUV, Rue de Bugnon 44, 07/2409, 1011 Lausanne, Switzerland.
authors.forename: Alain M
authors.initials: AM
authors.lastname: Schoepfer
authors.affiliation: Division of Gastroenterology, Esophageal Center, Northwestern University Feinberg School of Medicine, 676 North Saint Clair, Suite 1400, Chicago, IL 60611, USA. Electronic address: i-hirano@northwestern.edu.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hirano
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Avenue, Southwest, Rochester, MN 55905, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Katzka
mesh_terms: D000465:Algorithms; D057765:Eosinophilic Esophagitis / Q000628:therapy*; D006801:Humans
keywords: Dysphagia; Eosinophilic esophagitis; Gastroesophageal reflux disease; Patient-reported outcomes; Treatment end points