title: Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling.
abstract: Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could upregulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University, Cancer Center of Guangzhou Medical University (CCGMU).
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.affiliation: The Medical Faculty of Jinan University.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine.
authors.forename: Qiaozhen
authors.initials: Q
authors.lastname: Su
authors.affiliation: Internal Medicine of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine.
authors.forename: Chang
authors.initials: C
authors.lastname: An
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Liang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017705:Lignans / Q000494:pharmacology*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D047368:Tumor Burden; D000074165:Zinc Finger E-box Binding Homeobox 2; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D018398:Homeodomain Proteins; D017705:Lignans; D035683:MicroRNAs; D012097:Repressor Proteins; D000074165:Zinc Finger E-box Binding Homeobox 2; C533895:MIRN141 microRNA, human; C492363:ZEB2 protein, human; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols