title: Periungual pyogenic granulomas due to topical tazarotene for nail psoriasis.
abstract: Tazarotene is a topically-applied, receptor-selective retinoid that has been shown to modulate several major pathogenic factors of psoriasis. Adverse effects are those of topical application of retinoids, the most common being mild to moderate burning, itching, stinging, and erythema, due to mild to moderate local skin irritation. While pyogenic granuloma-like lesions are a well recognized side effects of systemic retinoids, to our knowledge in the literature there is only one reported case of pyogenic granuloma (PG) following topical application of tazarotene for scalp psoriasis. In this paper we report 2 cases of periungual PGs following application of topical tazarotene and we present a review of the literature.
authors.affiliation: Division of Dermatology, Department of Experimental, Diagnostic and Specialty MedicineUniversity of Bologna, Bologna, Italy - biancamaria.piraccini@unibo.it.
authors.forename: B M
authors.initials: BM
authors.lastname: Piraccini
authors.forename: M
authors.initials: M
authors.lastname: Venturi
authors.forename: A
authors.initials: A
authors.lastname: Patrizi
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D017789:Granuloma, Pyogenic / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000188:drug therapy* / Q000209:etiology; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy*; D012176:Retinoids
chemical_list: D003879:Dermatologic Agents; D009539:Nicotinic Acids; C086827:tazarotene; D012176:Retinoids