title: Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats.
abstract: Obesity is a risk factor leading to a number of chronic and metabolic disorders. Obesity is the fifth leading cause of global deaths. At least 2.8 million adults are dying each year as being overweight or obese. Cinnamomi cassiae is widely used traditional medicinal plant, used indigenously, to decrease glucose and cholesterol. 5-Hydroxy tryptamine (5-HT; Serotonin) is an important neurotransmitter reported to be involved in the pathophysiology of anorexia. Present study was designed to investigate the neurochemical and behavioral effects of cinnamon bark aqueous extract (CBAE) in obese rats and to find the possible involvement of 5-HT in reducing the body weight in these experimental animals. CBAE was repeatedly administered orally in the test animals for 5 weeks. A decrease in the food intake along with a concomitant increase in brain 5-HT level was observed in rats administered with CBAE. Findings may help in extending therapeutics in the pathophysiology of obesity and related eating disorders. Decrease activities in behavioral models were also monitored in CBAE treated animals.
authors.affiliation: Department of Biochemistry, Jinnah Medical and Dental College, Karachi, Pakistan.
authors.forename: Farhat
authors.initials: F
authors.lastname: Bano
authors.affiliation: Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Huma
authors.initials: H
authors.lastname: Ikram
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Naheed
authors.initials: N
authors.lastname: Akhtar
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002935:Cinnamomum zeylanicum; D004435:Eating / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000032:analysis*
chemical_list: D010936:Plant Extracts; D012701:Serotonin