title: Scattering coefficients of mice organs categorized pathologically by spectral domain optical coherence tomography.
abstract: Differences in tissue density cause a variety of scattering coefficients. To quantify optical coherence tomography (OCT) images for diagnosis, the tissue's scattering coefficient is estimated by curve fitting the OCT signals to a confocal single backscattering mode. The results from a group of 30 mice show that the scattering coefficients of bone, skin, liver, brain, testis, and spleen can be categorized into three groups: a scattering coefficient between 1.947 and 2.134 mm(-1): bone and skin; a scattering coefficient between 1.303 and 1.461 mm(-1): liver and brain; a scattering coefficient between 0.523 and 0.634 mm(-1): testis and spleen. The results indicate that the scattering coefficient is tissue specific and could be used in tissue diagnosis.
authors.affiliation: Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Zhang
authors.affiliation: Nankai University Affiliated Hospital, Tianjin 300121, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Wu
authors.affiliation: Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.
authors.forename: S W
authors.initials: SW
authors.lastname: Zhu
authors.affiliation: Nankai University Affiliated Hospital, Tianjin 300121, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA.
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Gao
authors.affiliation: Institute of Micro & Nano Optics, Shenzhen University, Shenzhen 518060, China.
authors.forename: X-C
authors.initials: XC
authors.lastname: Yuan
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000737:chemistry; D001923:Brain Chemistry; D006652:Histological Techniques / Q000379:methods*; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012542:Scattering, Radiation; D012867:Skin / Q000737:chemistry; D041623:Tomography, Optical Coherence / Q000379:methods*