title: WHO guidelines for antiretroviral therapy in serodiscordant couples in sub-Saharan Africa: how many fit?
abstract: To evaluate the implication of WHO guidelines for serodiscordant couples, we interviewed HIV-infected adults on their partner's serostatus. We found that 12% with more than 500 CD4+ cells/μl should be recommended antiretroviral treatment (ART) because their partner was seronegative; 24% could be recommended not to start ART because their partner was seropositive; and 64% could not be given any recommendation regarding ART early initiation because they had either no stable partnership (30%) or were in a stable partnership with a partner whose status they were not aware of (34%).
authors.affiliation: aPAC-CI, ANRS Research Site, Abidjan, Côte d'Ivoire bInserm, U897, University of Bordeaux, Bordeaux, France cInfectious Diseases Department, Treichville University Hospital, Abidjan, Côte d'Ivoire dInserm, UMRS 1018, Université Versailles Saint-Quentin, Villejuif eCEPED (Centre de Population et Développement), UMR 196, Ined, IRD, Université Paris Descartes, Paris, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Kouamé
authors.forename: Christine
authors.initials: C
authors.lastname: Danel
authors.forename: Raoul
authors.initials: R
authors.lastname: Moh
authors.forename: Anani
authors.initials: A
authors.lastname: Badjé
authors.forename: Kevin
authors.initials: K
authors.lastname: Jean
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: N'takpe
authors.forename: Delphine
authors.initials: D
authors.lastname: Gabillard
authors.forename: Jérome
authors.initials: J
authors.lastname: Le Carrou
authors.forename: Annabel Desgrées
authors.initials: AD
authors.lastname: du Loû
authors.forename: Nina
authors.initials: N
authors.lastname: Deschamps
authors.forename: Serge
authors.initials: S
authors.lastname: Eholie
authors.forename: Xavier
authors.initials: X
authors.lastname: Anglaret
mesh_terms: D000328:Adult; D017954:Africa South of the Sahara; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005191:Family Characteristics; D005260:Female; D019983:Guideline Adherence; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D014944:World Health Organization