title: Regional heterogeneity in cardiac sympathetic innervation in acute myocardial infarction: relationship with myocardial oedema on magnetic resonance.
abstract: OBJECTIVE
  To assess the relationships between myocardial structure and function on cardiac magnetic resonance (CMR) imaging and sympathetic tone on (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy early after myocardial infarction (MI).
  
  
  METHODS
  Ten patients underwent (123)I-MIBG and (99m)Tc-tetrofosmin rest cadmium zinc telluride scintigraphy 4 ± 1 days after MI. The segmental left ventricular (LV) relative radiotracer uptake of both (99m)Tc-tetrofosmin and early (123)I-MIBG was calculated. The day after scintigraphy, on CMR imaging, the extent of ischaemia-related oedema and of myocardial fibrosis (late gadolinium enhancement, LGE) was assessed. Accordingly, the extent of oedema and LGE was evaluated for each segment and segmental wall thickening determined. Based on LGE distribution, LV segments were categorized as "infarcted" (56 segments), "adjacent" (66 segments) or "remote" (48 segments).
  
  
  RESULTS
  Infarcted segments showed a more depressed systolic wall thickening and greater extent of oedema than adjacent segments (p < 0.001) and remote segments (p < 0.001). Interestingly, while uptake of (99m)Tc-tetrofosmin was significantly depressed only in infarcted segments (p < 0.001 vs. both adjacent and remote segments), uptake of (123)I-MIBG was impaired not only in infarcted segments (p < 0.001 vs. remote) but also in adjacent segments (p = 0.024 vs. remote segments). At the regional level, after correction for (99m)Tc-tetrofosmin and LGE distribution, segmental (123)I-MIBG uptake (p < 0.001) remained an independent predictor of ischaemia-related oedema.
  
  
  CONCLUSIONS
  After acute MI the regional impairment of sympathetic tone extends beyond the area of altered myocardial perfusion and is associated with myocardial oedema.
authors.affiliation: Fondazione CNR/Regione Toscana, Via Moruzzi, 1, 56124, Pisa, Italy, gimelli@ftgm.it.
authors.forename: Alessia
authors.initials: A
authors.lastname: Gimelli
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Masci
authors.forename: Riccardo
authors.initials: R
authors.lastname: Liga
authors.forename: Chrysanthos
authors.initials: C
authors.lastname: Grigoratos
authors.forename: Emilio Maria
authors.initials: EM
authors.lastname: Pasanisi
authors.forename: Massimo
authors.initials: M
authors.lastname: Lombardi
authors.forename: Paolo
authors.initials: P
authors.lastname: Marzullo
mesh_terms: D019797:3-Iodobenzylguanidine; D000208:Acute Disease; D000368:Aged; D002104:Cadmium; D004487:Edema / Q000150:complications*; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013691:Tellurium; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D019797:3-Iodobenzylguanidine; D015032:Zinc; D013691:Tellurium