title: Predictive factors of outcomes in personalized radioactive iodine ((131)I) treatment for Graves' disease.
abstract: BACKGROUND
  Graves' disease (GD) is the most common cause of hyperthyroidism in iodine-sufficient areas. Radioactive iodine I treatment (RIT), as the 1st therapeutic option, is widely accepted by doctors and patients. The aim of this study was to investigate factors influencing the success rate of calculated RIT in GD.
  
  
  METHODS
  Thyroid function outcome (hyperthyroidism or euthyroidism/hypothyroidism) was verified retrospectively at least 1 year after RIT and was compared with presenting clinical characteristics and pre-RIT parameters in 167 patients with GD treated with I-iodide in the authors' institute.
  
  
  RESULTS
  After RIT, 83 patients (49.7%) became euthyroid, 64 patients (38.3%) became hypothyroid and 20 (12.0%) remained hyperthyroid. Multiple logistic regression analyses demonstrated that there was no statistically significant association between RIT outcomes and sex, age, history of GD, previous antithyroid drug treatment, thyroid hormone levels, thyroid gland mass or radioactive iodine I dosage. The only variables associated with the success rate were the course of disease over 6 months (odds ratio, 3.70; confidence interval, 1.75-7.17; P = 0.014) and 2-hour radioactive iodine uptake (RAIU) >58.5% (odds ratio, 4.08; confidence interval, 2.03-7.83; P = 0.005).
  
  
  CONCLUSIONS
  Our study has shown that a calculated approach for the treatment of GD was effective, but high failure rates were observed in patients presenting higher 2-hour RAIU, particularly those with 2-hour RAIU of more than 58.5%.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Danqing
authors.initials: D
authors.lastname: Jing
authors.forename: Jingsheng
authors.initials: J
authors.lastname: Hu
authors.forename: Shinan
authors.initials: S
authors.lastname: Yin
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis* / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D057285:Precision Medicine / Q000379:methods*; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes