title: ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer's disease.
abstract: While it is well known that angiotensin converting enzyme (ACE) plays an important role in blood pressure control, ACE also has effects on renal function, hematopoiesis, reproduction, and aspects of the immune response. ACE 10/10 mice overexpress ACE in myelomonocytic cells. Macrophages from these mice have an increased polarization towards a pro-inflammatory phenotype that results in a very effective immune response to challenge by tumors or bacterial infection. In a mouse model of Alzheimer's disease (AD), the ACE 10/10 phenotype provides significant protection against AD pathology, including reduced inflammation, reduced burden of the neurotoxic amyloid-β protein and preserved cognitive function. Taken together, these studies show that increased myelomonocytic ACE expression in mice alters the immune response to better defend against many different types of pathologic insult, including the cognitive decline observed in an animal model of AD.
authors.affiliation: Department of Neurosurgery and the Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
authors.forename: Maya
authors.initials: M
authors.lastname: Koronyo-Hamaoui
authors.forename: Kandarp
authors.initials: K
authors.lastname: Shah
authors.forename: Yosef
authors.initials: Y
authors.lastname: Koronyo
authors.forename: Ellen
authors.initials: E
authors.lastname: Bernstein
authors.forename: Jorge F
authors.initials: JF
authors.lastname: Giani
authors.forename: Tea
authors.initials: T
authors.lastname: Janjulia
authors.forename: Keith L
authors.initials: KL
authors.lastname: Black
authors.forename: Peng D
authors.initials: PD
authors.lastname: Shi
authors.forename: Romer A
authors.initials: RA
authors.lastname: Gonzalez-Villalobos
authors.forename: Sebastien
authors.initials: S
authors.lastname: Fuchs
authors.forename: Xiao Z
authors.initials: XZ
authors.lastname: Shen
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Bernstein
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D009000:Monocytes / Q000201:enzymology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007703:Peptidyl-Dipeptidase A