title: [Successful autologous haematopoietic stem cell transplantation in severe, therapy-resistant childhood Crohn's disease. Report on the first case in Hungary].
abstract: The biological therapy of Crohn's disease, such as infliximab is a powerful approach in the therapy of inflammatory bowel diseases. However, in some patients with aggressive disease course, even a combined immunosuppressive therapy will not result in permanent remission. Hematopoietic stem cell transplantation has emerged as a new potential therapeutic tool for inflammatory bowel diseases. The authors report the case of a 15-year-old boy with severe Crohn's disease resistant to combined immunosuppressive therapy. After a 3-years course of unsuccessful conventional therapy including infliximab, autologous hematopoietic stem cell transplantation was performed which resulted in a complete remission. One year after transplantation the patient has relapsed, but he could be treated effectively with conventional therapy regiments. To the best of knowledge of the authors, this is the first report in Hungary presenting hematopoietic stem cell therapy in patient with severe Crohn's disease.
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest Albert Flórián u. 5-7. 1097.
authors.forename: Gergely
authors.initials: G
authors.lastname: Kriván
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Gyermekgyógyászati Klinika Budapest.
authors.forename: Dolóresz
authors.initials: D
authors.lastname: Szabó
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest Albert Flórián u. 5-7. 1097.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Kállay
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest Albert Flórián u. 5-7. 1097.
authors.forename: Gábor
authors.initials: G
authors.lastname: Benyó
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest Albert Flórián u. 5-7. 1097.
authors.forename: Csaba
authors.initials: C
authors.lastname: Kassa
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest Albert Flórián u. 5-7. 1097.
authors.forename: János
authors.initials: J
authors.lastname: Sinkó
authors.affiliation: Egyesített Szent István és Szent László Kórház Budapest Albert Flórián u. 5-7. 1097.
authors.forename: Vera
authors.initials: V
authors.lastname: Goda
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Gyermekgyógyászati Klinika Budapest.
authors.forename: András
authors.initials: A
authors.lastname: Arató
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Gyermekgyógyászati Klinika Budapest.
authors.forename: Gábor
authors.initials: G
authors.lastname: Veres
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004351:Drug Resistance; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D006814:Hungary; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D000069285:Infliximab; D008297:Male; D012720:Severity of Illness Index; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents; D000069285:Infliximab
keywords: Crohn-betegség; Crohn’s disease; autologous hematopoietic stem cell transplantation; autológ haemopoeticus őssejt-transzplantáció