title: The management of antibody-mediated rejection in the first presensitized recipient of a full-face allotransplant.
abstract: We report on the management of the first full-face transplantation in a sensitized recipient with a positive preoperative crossmatch and subsequent antibody-mediated rejection (AMR). The recipient is a 45-year-old female who sustained extensive chemical burns, with residual poor function and high levels of circulating anti-HLA antibodies. With a clear immunosuppression plan and salvage options in place, a full-face allotransplant was performed using a crossmatch positive donor. Despite plasmapheresis alongside a standard induction regimen, clinical signs of rejection were noted on postoperative day 5 (POD5). Donor-specific antibody (DSA) titers rose with evidence of C4d deposits on biopsy. By POD19, biopsies showed Banff Grade III rejection. Combination therapy consisting of plasmapheresis, eculizumab, bortezomib and alemtuzumab decreased DSA levels, improved clinical exam, and by 6 months postop she had no histological signs of rejection. This case is the first to demonstrate evidence and management of AMR in face allotransplantation. Our findings lend support to the call for an update to the Banff classification of rejection in vascularized composite tissue allotransplantation (VCA) to include AMR, and for further studies to better classify the histology and mechanism of action of AMR in VCA.
authors.affiliation: Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA.
authors.forename: A
authors.initials: A
authors.lastname: Chandraker
authors.forename: R
authors.initials: R
authors.lastname: Arscott
authors.forename: G F
authors.initials: GF
authors.lastname: Murphy
authors.forename: C G
authors.initials: CG
authors.lastname: Lian
authors.forename: E M
authors.initials: EM
authors.lastname: Bueno
authors.forename: F M
authors.initials: FM
authors.lastname: Marty
authors.forename: H G
authors.initials: HG
authors.lastname: Rennke
authors.forename: E
authors.initials: E
authors.lastname: Milford
authors.forename: S G
authors.initials: SG
authors.lastname: Tullius
authors.forename: B
authors.initials: B
authors.lastname: Pomahac
mesh_terms: D064591:Allografts; D054445:Facial Transplantation; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged
keywords: Antibody-mediated rejection; C4d; crossmatch; donor-specific antibodies; face allotransplantation; vascularized composite tissue allotransplantation