title: Crosslinked poly(ethylene glycol) hydrogels with degradable phosphamide linkers used as a drug carrier in cancer therapy.
abstract: A series of degradable, water-swellable PEGs are prepared using crosslinking between primary amines of N,N',N″-tris(2-aminoethyl)phosphoric triamide (TAEPT) and diglycidyl ether of epichlorohydrin-modified PEGs (EMPs). In the crosslinking process, the glycidyl ether is mainly consumed by the -NH2 of TAEPT and the hydroxyl generated from the opened glycidyl ethers (C-OH), producing degradable phosphonyl-amide frameworks as crosslinked points, and ether bonds as short branches, respectively. Studies on anticancer drug entrapment, chemoimmunotherapy agent delivery, degradation, and biological cytotoxicity in vitro suggest that the generated hydrogels have great potential as biomaterials in biomedical applications.
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University Pusan, 609-735, Republic of Korea.
authors.forename: Lidong
authors.initials: L
authors.lastname: Zhang
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: Sudan
authors.initials: S
authors.lastname: Zheng
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kang
authors.forename: Hongsuk
authors.initials: H
authors.lastname: Suh
authors.forename: Il
authors.initials: I
authors.lastname: Kim
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003432:Cross-Linking Reagents / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers; D004339:Drug Compounding; D004811:Epichlorohydrin / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009943:Organophosphorus Compounds / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004852:Epoxy Compounds; D020100:Hydrogels; D009943:Organophosphorus Compounds; C020344:glycidyl ethers; D004811:Epichlorohydrin; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: cancer therapy; drug carriers; hydrogel networks; implants; phosphamide linkers