title: Solitary plexiform neurofibroma of the stomach: a case report.
abstract: Plexiform neurofibroma (PN) of the digestive tract is very rare and usually part of the generalized syndrome of neurofibromatosis type 1 (von Recklinghausen disease). Solitary PN of the stomach is extremely rare and has not been reported in the literatures. Here we present a case of solitary PN of the stomach, which was not associated with von Recklinghausen disease. A 38-year-old male presented abdominal pain and distention for 7 d. The patient underwent endoscopy of the upper gastrointestinal tract, which revealed a 3.5 cm protruding and cauliflower-shaped mass with a shallow 1 cm central ulcer in the greater curvature of the stomach. The lesion was removed by laparoscopic surgery. Histological examination demonstrated characteristic histological findings of spindle-shaped cells. Immunohistochemical analysis showed that the tumor cells were positive for S-100 protein, but negative for CD34, KI-67, CD117, and actin. Based on histological findings, gastrointestinal stromal tumor could be excluded, and thus the case was confirmed as PN. We described the clinical features, physical examination, endoscopic findings, and histopathological examination of this case.
authors.affiliation: Lei Shi, Fu-Jian Liu, Qiu-Hong Jia, Hang Guan, Zhao-Jiong Lu, Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi Zhuang Autonomous Region, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Lei Shi, Fu-Jian Liu, Qiu-Hong Jia, Hang Guan, Zhao-Jiong Lu, Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi Zhuang Autonomous Region, China.
authors.forename: Fu-Jian
authors.initials: FJ
authors.lastname: Liu
authors.affiliation: Lei Shi, Fu-Jian Liu, Qiu-Hong Jia, Hang Guan, Zhao-Jiong Lu, Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi Zhuang Autonomous Region, China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Jia
authors.affiliation: Lei Shi, Fu-Jian Liu, Qiu-Hong Jia, Hang Guan, Zhao-Jiong Lu, Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi Zhuang Autonomous Region, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Guan
authors.affiliation: Lei Shi, Fu-Jian Liu, Qiu-Hong Jia, Hang Guan, Zhao-Jiong Lu, Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi Zhuang Autonomous Region, China.
authors.forename: Zhao-Jiong
authors.initials: ZJ
authors.lastname: Lu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D010535:Laparoscopy; D008297:Male; D018318:Neurofibroma, Plexiform / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Abdominal pain; Neurofibromatosis; Plexiform neurofibroma; Von Recklinghausen disease