title: Methionine synthase reductase A66G polymorphism is not associated with breast cancer susceptibility - a meta-analysis.
abstract: BACKGROUND
  Several studies have investigated the association between methionine synthase reductase (MTRR) A66G polymorphism and breast cancer risk, but controversial results were yielded. Therefore, we performed a meta-analysis to provide a more robust estimate of the effect of this polymorphism on susceptibility to breast cancer.
  
  
  METHODS
  Case-control studies investigating the relationship between MTRR A66G polymorphism and breast cancer risk were included by searching PubMed, EMBASE, China National Knowledge Infrastructure and Wanfang Database. Either fixed-effects or random-effects models were applied to calculate odds ratios(ORs) and 95% confidence intervals (CIs) by RevMan5.2 software.
  
  
  RESULTS
  A total of 9 studies bearing 7,097 cases and 7,710 controls were included in the meta-analysis. The results were that the combined ORs and 95%CIs of MTRR 66AG, GG, (AG+GG) genotypes were 0.98(0.91-1.05), 1.06(0.97-1.16) and 1.02(0.94-1.10), respectively with p=0.52, 0.19 and 0.65. We also performed subgroup analysis by specific ethnicity. The results of the combined analysis of MTRR 66AG, GG, (AG+GG) genotypes and breast cancer in Asian descent were Z=0.50, 0.53 and 0.21, with p all>0.05; for breast cancer in Caucasian descent, the results were Z=1.14, 1.65 and 0.43, with p all>0.05.
  
  
  CONCLUSIONS
  Our findings suggested that MTRR A66G polymorphism was not associated with breast cancer susceptibility.
authors.affiliation: Medical College, Henan University of Science and Technology, Luoyang, China E-mail : lhongchao@hotmail.com.
authors.forename: Shu
authors.initials: S
authors.lastname: Hu
authors.forename: Hong-Chao
authors.initials: HC
authors.lastname: Liu
authors.forename: Shou-Ming
authors.initials: SM
authors.lastname: Xi
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase