title: Moderate intensity exercise is associated with decreased angiotensin-converting enzyme, increased β2-adrenergic receptor gene expression, and lower blood pressure in middle-aged men.
abstract: OBJECTIVE
  The purpose of the current study was to characterize the role of aerobic exercise in the gene expression of the angiotensin-converting enzyme (ACE) and the β2-adrenergic receptor (ADRB2) in untrained men.
  
  
  METHODS
  Twenty untrained middle-aged men were randomly assigned to exercise (Exe) and control (Con) groups. The Exe group performed aerobic exercises for eight weeks. ACE mRNA and ADRB2 mRNA were determined by PCR.
  
  
  RESULTS
  The expression of ACE in week 4 and in the Exe group decreased significantly (p < .001). ADRB2 in the Exe group, in week 4 and in week 8, was markedly higher, and blood pressure was significantly lower than in the Con group (p < .001). In the Con group ADRB2 mRNA decreased.
  
  
  CONCLUSIONS
  These results suggest that moderate intensity exercise promotes the leukocyte expression of gene markers that may affect blood pressure by improving cardiovascular fitness levels in middle-aged men.
authors.affiliation: Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University, Urmia, Iran.
authors.forename: Bakhtyar
authors.initials: B
authors.lastname: Tartibian
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Botelho Teixeira
authors.forename: Behrouz
authors.initials: B
authors.lastname: Baghaiee
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001795:Blood Pressure Determination; D015444:Exercise / Q000502:physiology*; D005819:Genetic Markers; D006801:Humans; D007022:Hypotension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction / Q000379:methods; D012333:RNA, Messenger / Q000032:analysis; D011943:Receptors, Adrenergic, beta / Q000235:genetics / Q000378:metabolism*; D012016:Reference Values; D018709:Statistics, Nonparametric
chemical_list: D005819:Genetic Markers; D012333:RNA, Messenger; D011943:Receptors, Adrenergic, beta; D007703:Peptidyl-Dipeptidase A