title: Central papillary cystadenocarcinoma of the mandible: A case report and review of the literature.
abstract: BACKGROUND
  Central papillary cystadenocarcinoma of the jaw is an extremely rare tumor with only three previously reported cases in the English literature. This tumor is a histologically low-grade cancer, affecting more commonly in the mandible than in the maxilla.
  
  
  METHODS
  A 65-year-old woman presented with a two months history of a rapidly growing, painless mass of the right ascending ramus of the mandible. The pathologic report from incisional biopsy was a papillary cystic tumor with a differential diagnosis of cystadenoma versus cystadenocarcinoma. Segmental mandibulectomy, parotidectomy and submandibular gland resection were performed. The final pathology was intraosseous papillary cystadenocarcinoma.
  
  
  CONCLUSIONS
  Clinical features of central papillary cystadenocarcinoma of the mandible mimic an odontogenic lesion and metastatic bone disease, careful review of radiograph and pathology should be done. Surgical excision with wide margins is the appropriate treatment. Postoperative radiation therapy should be considered in histologically aggressive or high-stage tumor.
  
  
  CONCLUSIONS
  This is the fourth case of central papillary cystadenocarcinoma of the mandible in the English literature. Although it is usually a low-grade cancer, en bloc resection with adjuvant postoperative radiotherapy in a high-stage disease, and long-term follow-up allow the patient to have a favorable prognosis.
authors.affiliation: Department of Otolaryngology, Phayao Hospital, Phayao, Thailand.
authors.forename: Chonticha
authors.initials: C
authors.lastname: Srivanitchapoom
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address: psittitrai@yahoo.com.
authors.forename: Pichit
authors.initials: P
authors.lastname: Sittitrai
authors.affiliation: Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Pongsak
authors.initials: P
authors.lastname: Mahanupab
keywords: Central; Intraosseous; Mandible; Papillary cystadenocarcinoma; Salivary gland neoplasm