title: Postoperative adverse effects after recent or remote lithium therapy.
abstract: Patients receiving preoperative lithium therapy for bipolar disorder may present unique challenges in the perioperative period and during critical illness. Two cases of critically ill patients who developed lithium-induced adverse reactions in the perioperative period due to the low therapeutic index are reported.
authors.affiliation: Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Ave./E31, Cleveland, OH 44195, USA. Electronic address: irefins@ccf.org.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Irefin
authors.affiliation: Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Ave./E31, Cleveland, OH 44195, USA.
authors.forename: Abraham
authors.initials: A
authors.lastname: Sonny
authors.affiliation: Department of Pharmacy, Cleveland Clinic, 9500 Euclid Ave./Hb105, Cleveland, OH 44195, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Harinstein
authors.affiliation: Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Ave./E31, Cleveland, OH 44195, USA.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Popovich
mesh_terms: D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D016638:Critical Illness; D005260:Female; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D018692:Antimanic Agents; D018020:Lithium Compounds
keywords: Bipolar disorder; Drug reactions; Hypernatremia; Hypovolemia; Lithium; Nephrogenic diabetes insipidus