title: Relationship between alcohol dependence and the DBI rs2276596 (C/A) polymorphism in Japanese.
abstract: To facilitate elucidation of the pathogenesis of alcohol dependence, we investigated the relationship between a genetic variant of diazepam biding inhibitor (DBI) C/A polymorphism (rs2276596) and alcohol dependence. We determined the DBI genotypes using a novel method involving PCR-RFLP in healthy controls and alcoholics with a diagnosis of alcohol dependence by ICD-10 (F10.20). There was a significant difference in the rs2276596 polymorphism C/A allele frequency of the DBI gene (P < 0.0001) between alcoholics and healthy controls. The present data suggested that a mutant allele of the DBI was one of the risk factors for alcohol dependence as for the rs2276596 polymorphism.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshihara
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashi
authors.forename: Chikako
authors.initials: C
authors.lastname: Waga
authors.forename: Ohoshi
authors.initials: O
authors.lastname: Murayama
authors.forename: Nobuyo
authors.initials: N
authors.lastname: Ohtani
authors.forename: Shin
authors.initials: S
authors.lastname: Narita
authors.forename: Kenta
authors.initials: K
authors.lastname: Nagahori
authors.forename: Maki
authors.initials: M
authors.lastname: Numajiri
authors.forename: Yuuya
authors.initials: Y
authors.lastname: Onozawa
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D026261:Diazepam Binding Inhibitor / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D026261:Diazepam Binding Inhibitor