title: [SAPHO syndrome].
abstract: SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a rare entity characterized by the association of heterogeneous osteoarticular and cutaneous manifestations that have for common denominator an aseptic inflammatory process. The etiopathogeny of this disease is still a matter of debate. Although it has been related to the spondylarthritis family, an infectious origin is suggested. Diagnosis is based on the presence of at least one of the three diagnostic criteria proposed by Kahn. The treatment includes NSAIDs, antibiotics, corticosteroids, methotrexate and more recently the bisphosphonates and the TNFα inhibitors.
authors.affiliation: Service de rhumatologie, hôpital militaire de Tunis, Tunis, Tunisie. Electronic address: imengharsallah@hotmail.fr.
authors.forename: I
authors.initials: I
authors.lastname: Gharsallah
authors.affiliation: Service de dermatologie, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Souissi
authors.affiliation: Service de rhumatologie, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Dhahri
authors.affiliation: Service de médecine interne, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: N
authors.initials: N
authors.lastname: Boussetta
authors.affiliation: Service de rhumatologie, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Sayeh
authors.affiliation: Service de rhumatologie, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: Métoui
authors.affiliation: Service de médecine interne, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Ajili
authors.affiliation: Service de médecine interne, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: B
authors.initials: B
authors.lastname: Louzir
authors.affiliation: Service de médecine interne, hôpital militaire de Tunis, Tunis, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Othmani
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D011379:Prognosis
keywords: Acne; Acné; Pustulose; Pustulosis; SAPHO; Spondylarthropathies; Spondyloarthropathies