title: [Sex cord gonadal stromal tumors].
abstract: According to the World Health Organization (WHO) classification from 2004, sex cord gonadal stromal tumors are divided into Leydig cell tumors, Sertoli cell tumors, granulosa cell tumors, tumors of the thecoma-fibroma group, incompletely differentiated sex cord gonadal stromal tumors, mixed forms of sex cord gonadal stromal tumors and tumors containing both germ cell and sex cord gonadal stromal elements. These tumors can appear sporadically or in combination with hereditary syndromes. To diagnose these rare tumors the combination of characteristic morphological aspects and various immunohistochemical markers is useful. Latest investigations demonstrate the potential role of mutation analyses in the diagnosis of this heterogeneous group of tumors.
authors.affiliation: Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland, Felix.bremmer@med.uni-goettingen.de.
authors.forename: F
authors.initials: F
authors.lastname: Bremmer
authors.forename: C L
authors.initials: CL
authors.lastname: Behnes
authors.forename: H-J
authors.initials: HJ
authors.lastname: Radzun
authors.forename: M
authors.initials: M
authors.lastname: Bettstetter
authors.forename: S
authors.initials: S
authors.lastname: Schweyer
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005350:Fibroma / Q000235:genetics / Q000473:pathology; D006106:Granulosa Cell Tumor / Q000235:genetics / Q000473:pathology; D006801:Humans; D007984:Leydig Cell Tumor / Q000235:genetics / Q000473:pathology; D008297:Male; D011379:Prognosis; D012707:Sertoli Cell Tumor / Q000235:genetics / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000235:genetics / Q000473:pathology*; D013736:Testicular Neoplasms / Q000235:genetics / Q000473:pathology*; D013737:Testis / Q000473:pathology; D013798:Thecoma / Q000235:genetics / Q000473:pathology