title: Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approaches.
abstract: Gastrointestinal cancers are asymptomatic in early tumor development, leading to high mortality rates. Peri- or postoperative chemotherapy is a common strategy used to prolong the life expectancy of patients with these diseases. Understanding the molecular mechanisms by which anticancer drugs exert their effect is crucial to the development of anticancer therapies, especially when drug resistance occurs and an alternative drug is needed. By integrating high-throughput techniques and computational modeling to explore biological systems at different levels, from gene expressions to networks, systems biology approaches have been successfully applied in various fields of cancer research. In this review, we highlight chemotherapy studies that reveal potential signatures using microarray analysis, next-generation sequencing (NGS), proteomic and metabolomic approaches for the treatment of gastrointestinal cancers.
authors.affiliation: Institute of Molecular and Cellular Biology, Department of Life Science, National Taiwan University, Taipei, Taiwan.
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Lin
authors.affiliation: Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei, Taiwan. Electronic address: hsuancheng@ym.edu.tw.
authors.forename: Hsuan-Cheng
authors.initials: HC
authors.lastname: Huang
authors.affiliation: Institute of Molecular and Cellular Biology, Department of Life Science, National Taiwan University, Taipei, Taiwan; Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. Electronic address: yukijuan@ntu.edu.tw.
authors.forename: Hsueh-Fen
authors.initials: HF
authors.lastname: Juan
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D003198:Computer Simulation; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D057166:High-Throughput Screening Assays; D006801:Humans; D055432:Metabolomics / Q000379:methods; D046228:Microarray Analysis; D058990:Molecular Targeted Therapy; D040901:Proteomics / Q000379:methods; D049490:Systems Biology / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents