title: Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments.
abstract: The behavior and fate of cells in tissues largely rely upon their cross-talk with the tissue microenvironment including neighboring cells, the extracellular matrix (ECM), and soluble cues from the local and systemic environments. Dysregulation of tissue microenvironment can drive various inflammatory diseases and tumors. The ECM is a crucial component of tissue microenvironment. ECM proteins can not only modulate tissue microenvironment but also regulate the behavior of surrounding cells and the homeostasis of tissues. As a nonstructural ECM protein, periostin is generally present at low levels in most adult tissues; however, periostin is often highly expressed at sites of injury or inflammation and in tumors within adult organisms. Current evidence demonstrates that periostin actively contributes to tissue injury, inflammation, fibrosis and tumor progression. Here, we summarize the roles of periostin in inflammatory and tumor microenvironments.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
authors.forename: Allan Yi
authors.initials: AY
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China. Electronic address: oygldz@xmu.edu.cn.
authors.forename: Gaoliang
authors.initials: G
authors.lastname: Ouyang
mesh_terms: D015815:Cell Adhesion Molecules / Q000378:metabolism* / Q000502:physiology*; D060833:Cellular Microenvironment / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: extracellular matrix; inflammation; matricellular protein; metastasis; microenvironment; periostin