title: New classification of directly compressible (DC) excipients in function of the SeDeM Diagarm Expert System.
abstract: As a methodology for characterizing substances with regard to its viability in direct compression, the SeDeM Diagram Expert System may be considered a new tool in terms of the number of parameters applied and its optimization. The paper is based on the experimental SeDeM characterization study of 51 directly compressible (DC) excipients. After selecting the parameters, and comparing the corresponding results, the choices available within the SeDeM Expert System could be expanded. Through applied variants, the maximum and optimal values of the DC diluent excipient were precisely defined and the mathematical limits of the parameters, functions and parametric indices that define the level of direct compressibility were established. These studies have allowed us to propose a new classification of excipients CD based on its rheological and compressibility capability, resulting in a periodic table of CD excipients. It has been determined that the best excipient for direct compression should have an index of good compression (IGC) of 8.832.
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Josep M
authors.initials: JM
authors.lastname: Suñé-Negre
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Roig
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Fuster
authors.affiliation: Bioiberica S.A., Polígono Industrial Mas Puigvert, s/n. 08389 Palafolls, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández
authors.affiliation: Bioiberica S.A., Polígono Industrial Mas Puigvert, s/n. 08389 Palafolls, Barcelona, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Ruhí
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain. Electronic address: encarnagarcia@ub.edu.
authors.forename: Encarna
authors.initials: E
authors.lastname: García-Montoya
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Pérez-Lozano
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Miñarro
authors.affiliation: Pharmaceutical Technology Unit. Pharmacy and Pharmaceutical Technology Department, Pharmacy Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Josep R
authors.initials: JR
authors.lastname: Ticó
mesh_terms: D019245:Compressive Strength; D005079:Excipients / Q000737:chemistry* / Q000145:classification*; D005103:Expert Systems; D010316:Particle Size; D016062:Porosity; D012212:Rheology
chemical_list: D005079:Excipients
keywords: Direct compression (DC); Good compression index (IGC); Optimal DC excipient; SeDeM; Tablet excipient; Tablet preformulation