title: Prenatal diagnosis of chromosomal imbalances.
abstract: Prenatal array comparative genome hybridisation (aCGH) testing has by and large replaced routine karyotyping in many healthcare settings. While this will lead to more diagnoses, uncertain, unexpected or unhelpful findings are also likely to increase. This is the case for aCGH in any setting, but we discuss the particular challenges the prenatal setting generates and suggest areas that need further debate and discussion as well as some pragmatic ways forward.
authors.forename: Diana G
authors.initials: DG
authors.lastname: Wellesley
authors.forename: Anneke
authors.initials: A
authors.lastname: Lucassen
mesh_terms: D002755:Choice Behavior; D025063:Chromosome Disorders / Q000175:diagnosis*; D055028:Comparative Genomic Hybridization / Q000379:methods; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D033162:Incidental Findings; D010290:Parents / Q000523:psychology; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*