title: Obstructive sleep apnea in younger school children with Down syndrome.
abstract: OBJECTIVE
  We aimed to assess the prevalence of obstructive sleep apnea (OSA) in 8 year old school children with Down syndrome (DS). While the prevalence in otherwise healthy children is below 5%, the prevalence estimates in children with DS are uncertain (30-80%). OSA directly affects cognitive development and school performance.
  
  
  METHODS
  Population based cross sectional study in a limited geographical area.
  
  
  METHODS
  Polysomnography (PSG) with video and audio recordings was performed in 8-year-old children with DS in a pediatric sleep unit according to the guidelines of American Academy of Sleep Medicine. Twenty-nine of all 32 children with DS within a restricted area comprising >50% of the Norwegian population and 54% of the children with DS born in Norway in 2002 were enrolled.
  
  
  RESULTS
  This study reports an apnea hypopnea index AHI>1.5 in 28 of 29 children and an obstructive apnea index (OAI)>1 in 24 of 29 children. 19 children (66%) had an AHI>5 and 17 children (59%) had an OAI>5 which indicated moderate to severe OSA. No correlation was found between OSA and obesity or gender.
  
  
  CONCLUSIONS
  The high prevalence of disease found in these previously undiagnosed 8-year-old children underlines the importance of performing OSA diagnostics in children with DS throughout childhood. These findings suggest that the prevalence of OSA remains high up to early school years. In contrast to earlier publications, this current study has the advantage of being population based, the study is performed on children of a narrow age band to estimate prevalence of disease and the diagnostic gold standard of PSG is applied.
authors.affiliation: Østfold Hospital Trust, Department of Otorhinolaryngology, Head and Neck Surgery, Norway; Department of Health Economics and Health Management, University of Oslo, Norway. Electronic address: Marit.Austeng@gmail.com.
authors.forename: Marit Erna
authors.initials: ME
authors.lastname: Austeng
authors.affiliation: Sleep Unit, Department of Otorhinolaryngology/Head and Neck Surgery, Lovisenberg Diakonale Hospital, Norway.
authors.forename: Britt
authors.initials: B
authors.lastname: Øverland
authors.affiliation: Department of Health Economics and Health Management, University of Oslo, Norway; Research, Innovation and Education Unit, Oslo University Hospital, Norway.
authors.forename: Kari Jorunn
authors.initials: KJ
authors.lastname: Kværner
authors.affiliation: TAKO-Centre, Resource Centre for Oral Health in Rare Medical Conditions, Lovisenberg Diakonale Hospital, Norway.
authors.forename: Els-Marie
authors.initials: EM
authors.lastname: Andersson
authors.affiliation: TAKO-Centre, Resource Centre for Oral Health in Rare Medical Conditions, Lovisenberg Diakonale Hospital, Norway.
authors.forename: Stefan
authors.initials: S
authors.lastname: Axelsson
authors.affiliation: Centre of Clinical Research, Unit of Biostatistics and Epidemiology, Oslo University Hospital, Norway.
authors.forename: Michael
authors.initials: M
authors.lastname: Abdelnoor
authors.affiliation: Sleep Unit, Department of Otorhinolaryngology/Head and Neck Surgery, Lovisenberg Diakonale Hospital, Norway.
authors.forename: Harriet
authors.initials: H
authors.lastname: Akre
mesh_terms: D002648:Child; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D009664:Norway / Q000453:epidemiology; D017286:Polysomnography; D015995:Prevalence; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*
keywords: Down syndrome; OSA; Pediatric