title: Cross-border reprogenetic services.
abstract: The purpose of this review is to synthesize the current knowledge on the international movement of patients and biopsied embryo cells for pre-implantation genetic diagnosis and its different applications. Thus far, few attempts have been made to identify the specific nature of this phenomenon called 'cross-border reprogenetic services'. There is scattered evidence, both empirical and speculative, suggesting that these services raise major issues in terms of service provision, risks for patients and the children-to-come, the legal liabilities of physicians, as well as social justice. To compile this evidence, this review uses the narrative overview protocol combined with thematic analysis. Five major themes have emerged from the literature at the conjunction of cross-border treatments and reprogenetics: 'scope', 'scale', 'motivations', 'concerns', and 'governance'. Similar themes have already been observed in the case of other medical tourism activities, but this review highlights their singularity with reprogenetic services. It emphasizes the diagnostic and autologous feature of reprogenetics, the constant risk of misdiagnosis, the restriction on certain tests for medically controversial conditions, and the uncertain accessibility of genetic counseling in cross-border settings.
authors.affiliation: Laboratory of Transdisciplinary Research in Genetics, Medicines and Social Sciences, Division of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Couture
authors.forename: R
authors.initials: R
authors.lastname: Drouin
authors.forename: S-L
authors.initials: SL
authors.lastname: Tan
authors.forename: J-M
authors.initials: JM
authors.lastname: Moutquin
authors.forename: C
authors.initials: C
authors.lastname: Bouffard
mesh_terms: D001706:Biopsy / Q000379:methods*; D004622:Embryo, Mammalian; D006801:Humans; D038622:Internationality / Q000331:legislation & jurisprudence*; D019836:Preimplantation Diagnosis / Q000379:methods*; D027724:Reproductive Techniques, Assisted; D014195:Travel / Q000331:legislation & jurisprudence / Q000639:trends*
keywords: genetic techniques; health care quality, access, and evaluation; histocompatibility testing; medical tourism; pre-implantation genetic diagnosis; pre-implantation screening; sex pre-selection