title: Follicle-stimulating hormone/luteinizing hormone ratio as an independent predictor of response to controlled ovarian stimulation.
abstract: OBJECTIVE
  To determine whether a follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio over 3 in the setting of a normal FSH (<12 IU/l) is associated with a higher rate of failed controlled ovarian stimulation cycles.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  A total of 676 patients were identified; 198 patients had a FSH/LH ratio >3 and 477 patients had a FSH/LH ratio <3. Exclusion criteria included: age >40 years; estradiol (E2) prime protocols; E2 at start >70 pg/ml; and FSH at start >12 IU/l. The main outcome measure was cycle cancellation.
  
  
  RESULTS
  An elevated FSH/LH ratio >3 was more likely to result in the individual's cycle cancelled (15 vs 5.24%; p = 0.0001). The total gonadotropin dosage was greater in the higher ratio versus lower ratio group (2636 vs 2242 IU; significant). Peak E2 was significantly lower in the FSH/LH >3 group (peak E2: 1635 vs 1942 pg/ml).
  
  
  CONCLUSIONS
  The value of the FSH/LH ratio in patients with normal FSH levels, may have a role in determining the appropriate stimulation protocol and predict cycle cancellations.
authors.affiliation: Department of Obstetrics & Gynecology, New York Presbyterian Hospital, 525 East 68th Street New York, NY 10021, USA. jason.kofinas@nyumc.org.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Kofinas
authors.forename: Rony T
authors.initials: RT
authors.lastname: Elias
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000008:administration & dosage* / Q000097:blood; D006080:Ovarian Follicle / Q000187:drug effects*; D010053:Ovary; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: FSH; assisted reproduction; follicle-stimulating hormone; in vitro fertilization; ovarian reserve