title: Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates.
abstract: A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated "auto-vaccination," the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.
authors.affiliation: Klinik für Onkologie und Hämatologie, Krankenhaus Nordwest, Frankfurt
authors.forename: Julia
authors.initials: J
authors.lastname: Karbach
authors.forename: Sacha
authors.initials: S
authors.lastname: Gnjatic
authors.forename: Melina
authors.initials: M
authors.lastname: Biskamp
authors.forename: Akin
authors.initials: A
authors.lastname: Atmaca
authors.forename: Eckhart
authors.initials: E
authors.lastname: Weidmann
authors.forename: Kathrin
authors.initials: K
authors.lastname: Brandt
authors.forename: Claudia
authors.initials: C
authors.lastname: Wahle
authors.forename: Helga
authors.initials: H
authors.lastname: Bernhard
authors.forename: Alexander
authors.initials: A
authors.lastname: Knuth
authors.forename: Elke
authors.initials: E
authors.lastname: Jäger
mesh_terms: D000328:Adult; D000906:Antibodies / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy; D008545:Melanoma / Q000150:complications* / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D008565:Membrane Proteins / Q000276:immunology; D016634:Radiosurgery; D012074:Remission Induction; D037182:T-Cell Antigen Receptor Specificity; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; C104948:CTAG1B protein, human; D019496:Cancer Vaccines; D008565:Membrane Proteins