title: Plasma amino acid profiles of breast cancer patients early in the trajectory of the disease differ from healthy comparison groups.
abstract: This study describes and compares fasting plasma amino acid profiles of breast cancer patients near the initiation of chemotherapy with those of healthy age- and body mass index-matched females (HM), as well as young healthy females (HY). Breast cancer patients had significantly greater glutamate and histidine concentrations and significantly lower threonine concentrations compared with HM and HY females independent of protein or caloric intake. These differences may be related to metabolic perturbations associated with the disease.
authors.affiliation: a Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
authors.forename: Tyler
authors.initials: T
authors.lastname: Barnes
authors.forename: Kirsten
authors.initials: K
authors.lastname: Bell
authors.forename: Katie M
authors.initials: KM
authors.lastname: DiSebastiano
authors.forename: Vivienne
authors.initials: V
authors.lastname: Vance
authors.forename: Rhona
authors.initials: R
authors.lastname: Hanning
authors.forename: Caryl
authors.initials: C
authors.lastname: Russell
authors.forename: Joel A
authors.initials: JA
authors.lastname: Dubin
authors.forename: Mala
authors.initials: M
authors.lastname: Bahl
authors.forename: Nadia
authors.initials: N
authors.lastname: Califaretti
authors.forename: Carolyn
authors.initials: C
authors.lastname: Campbell
authors.forename: Marina
authors.initials: M
authors.lastname: Mourtzakis
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001823:Body Composition; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy; D016022:Case-Control Studies; D002149:Energy Intake; D005260:Female; D018698:Glutamic Acid / Q000097:blood; D005973:Glutamine / Q000097:blood; D006639:Histidine / Q000097:blood; D006801:Humans; D007930:Leucine / Q000097:blood; D008875:Middle Aged; D013912:Threonine / Q000097:blood
chemical_list: D000596:Amino Acids; D005973:Glutamine; D013912:Threonine; D018698:Glutamic Acid; D006639:Histidine; D007930:Leucine
keywords: acides aminés essentiels; essential amino acids; glutamate; glutamine; histidine; leucine; threonine; thréonine