title: The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis.
abstract: Objective. Recent studies have demonstrated that enteric glial cells (EGC) participate in the homeostasis of the gastrointestinal tract. This study investigated whether enteroglial markers, including S100B protein and glial fibrillary acidic protein (GFAP), can serve as noninvasive indicators of EGC activation and disease activity in UC patients. Methods. This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls. The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria. Clinical disease activity was evaluated using the Modified Truelove-Witts Severity Index. Serum samples were analyzed for human GFAP and S100B using commercial enzyme-linked immunosorbent assay kits. Results. GFAP was not detected in the serum of either UC patients or controls (P > 0.05). However, we found a significant (P < 0.001) decrease in the serum S100B levels in the UC patients. No correlation between the serum S100B level and the disease activity or duration was observed (P > 0.05). The serum S100B levels did not differ between UC patients with active disease (24 patients, 68.6%) or in remission (11 patients, 31.4%) (P > 0.05). Conclusions. Ulcerative colitis patients had significantly lower serum S100B levels, while GFAP was of no diagnostic value in UC patients.
authors.affiliation: Department of Neurology, Medical School, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Asuman
authors.identifier: 0000-0002-2367-1128
authors.initials: A
authors.lastname: Celikbilek
authors.affiliation: Department of Gastroenterology, Medical School, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Mehmet
authors.identifier: 0000-0001-8890-3885
authors.initials: M
authors.lastname: Celikbilek
authors.affiliation: Department of Medical Biology, Medical School, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Sabah
authors.affiliation: Department of Neurology, Medical School, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Tanık
authors.affiliation: Department of Internal Medicine, Medical School, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Borekci
authors.affiliation: Department of Gastroenterology, Medical School, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Dogan
authors.affiliation: Department of Internal Medicine, Medical School, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Akin
authors.affiliation: Department of Internal Medicine, Medical School, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Baldane
authors.affiliation: Department of Pathology, Medical School, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Deniz
authors.affiliation: Department of Infectious Diseases and Microbiology, Medical School, Bozok University, 66200 Yozgat, Turkey.
authors.forename: Neziha
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: Department of Gastroenterology, Medical School, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Ozbakir
authors.affiliation: Department of Gastroenterology, Medical School, Erciyes University, 38039 Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yucesoy