title: The effects of novel, bioresorbable scaffolds on coronary vascular pathophysiology.
abstract: Percutaneous coronary intervention (PCI) has rapidly evolved over the past 30 years as technology has sought to improve clinical outcomes by addressing pathophysiologic complications arising from the intervention. Stents were designed to resolve the drawbacks of balloon angioplasty by providing radial support to prevent vessel recoil, by sealing coronary dissections, and by preventing abrupt vessel closure. The conceptualization of an ideal drug-eluting fully bioresorbable scaffold (BRS), whether metallic or polymeric, would theoretically address the adverse aspects of permanent metallic stents. In this review of the literature, we will discuss the impact these novel fully BRS platforms have on vascular pathophysiology following PCI.
authors.affiliation: MedStar Cardiovascular Research Network, MedStar Heart Institute, MedStar Washington Hospital Center, 110 Irving St., NW, Suite 4B-1, Washington, DC, 20010, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lipinski
authors.forename: Ricardo O
authors.initials: RO
authors.lastname: Escarcega
authors.forename: Thibault
authors.initials: T
authors.lastname: Lhermusier
authors.forename: Ron
authors.initials: R
authors.lastname: Waksman
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000503:physiopathology*; D054855:Drug-Eluting Stents; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011474:Prosthesis Design; D015607:Stents; D016896:Treatment Outcome