title: Alpha-1 antitrypsin deficiency and spontaneous pneumothorax: possible causal relationship.
abstract: BACKGROUND
  An increased incidence of serum alpha-1 antitrypsin deficiency has been reported in patients with chronic obstructive pulmonary disease, but has not been well proven in association with spontaneous pneumothorax. The aim of our study was to evaluate frequency of alpha-1 antitrypsin deficiency in subjects with spontaneous pneumothorax.
  
  
  METHODS
  39 patients with the diagnosis of spontaneous pneumothorax and 100 age- and sex-matched control subjects were included in the study. Alpha-1 antitrypsin concentrations were determined by nephelometry, Serum qualitative Z antitrypsin variant was analyzed using commercial ELISA kits and alpha-1 antitrypsin phenotyping was carried out by means of isoelectric focusing.
  
  
  RESULTS
  AAT deficiency phenotypes were detected in 3 (7.7%) patients with spontaneous pneumothorax, and only in 1 (1%) case in the control group. However, the observed differences did not reach statistical significance due to the considerable size disproportion between groups. The mean serum alpha-1 antitrypsin level was significantly higher in patients with spontaneous pneumothorax (1.53 +/- 0.23 g/l) than controls (1.34 +/- 0.37 g/l) (p = 0.03).
  
  
  CONCLUSIONS
  Preliminary data confirm the clinical importance of alpha-1 antitrypsin deficiency phenotypes in patients with spontaneous pneumothorax and the need to screen them for alpha1-antitrypsin deficiency.
authors.forename: Danielius
authors.initials: D
authors.lastname: Serapinas
authors.forename: Viltaute
authors.initials: V
authors.lastname: Obrikyte
authors.forename: Dalius
authors.initials: D
authors.lastname: Vaicius
authors.forename: Ruta
authors.initials: R
authors.lastname: Balciuviene
authors.forename: Arvydas
authors.initials: A
authors.lastname: Valavicius
authors.forename: Raimundas
authors.initials: R
authors.lastname: Sakalauskas
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015994:Incidence; D008097:Lithuania / Q000453:epidemiology; D008297:Male; D009391:Nephelometry and Turbidimetry; D010641:Phenotype; D011030:Pneumothorax / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014361:Trypsin Inhibitors / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000097:blood*; D019896:alpha 1-Antitrypsin Deficiency / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin