title: Antibacterial activities of persimmon extracts relate with their hydrogen peroxide concentration.
abstract: Persimmon, a deciduous tree of the family Ebenaceae, is found throughout East Asia and contains high levels of tannins. This class of natural compounds exhibit favorable toxicity profiles along with bactericidal activity without the emergence of resistant bacteria, suggesting potential medical applications. Consistent with these observations, persimmon leaves show antibacterial activity. However, the mechanism of persimmon antibacterial activity remains unknown. In the present work, we demonstrate that the antibacterial activity of persimmon reflects the generation of reactive oxygen from tannins. The identification and quantification of reactive oxygen generated from persimmon and the level of antibacterial activity were determined.
authors.affiliation: Analytical Biochemistry, School of Pharmacy, Showa University.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Arakawa
authors.forename: Makiko
authors.initials: M
authors.lastname: Takasaki
authors.forename: Noriko
authors.initials: N
authors.lastname: Tajima
authors.forename: Haruka
authors.initials: H
authors.lastname: Fukamachi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Igarashi
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D015169:Colony Count, Microbial; D029788:Diospyros / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis*; D008826:Microbial Sensitivity Tests; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D006861:Hydrogen Peroxide