title: Lichen planopilaris is associated with HLA DRB1*11 and DQB1*03 alleles.
abstract: There are no studies of the possible association of the human leukocyte antigen (HLA) system with lichen planopilaris (LPP). To determine whether the HLA system is associated with LPP, 40 consecutive Jewish Israeli patients with LPP (study group) and 252 volunteers (controls) were typed for DRB1*and DQB1* loci by molecular methods. Compared with controls, the study group had a significantly higher frequency of the DRB1*11 allele (62% vs. 21%, corrected p-value (pc) = 0.001) owing to increased frequencies of DRB1*11: 01 and DRB1*11: 04. The DQB1*03 allele was also expressed at a significantly higher frequency in the study group (70% vs. 33%, pc = 0.0005); specifically, the frequency of DQB1*03: 01 was increased. The majority (82.5%) of the patients were of non-Ashkenazi origin. We conclude that LPP appears to be over-represented in non-Ashkenazi Jewish patients and is associated with an increased frequency of HLA DRB1*11 and DQB1*03 alleles. These findings suggest that immunogenetic factors play a role in LPP.
authors.affiliation: Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel.
authors.forename: Lev
authors.initials: L
authors.lastname: Pavlovsky
authors.forename: Moshe
authors.initials: M
authors.lastname: Israeli
authors.forename: Eti
authors.initials: E
authors.lastname: Sagy
authors.forename: Amy L
authors.initials: AL
authors.lastname: Berg
authors.forename: Michael
authors.initials: M
authors.lastname: David
authors.forename: Avner
authors.initials: A
authors.lastname: Shemer
authors.forename: Tirza
authors.initials: T
authors.lastname: Klein
authors.forename: Emmilia
authors.initials: E
authors.lastname: Hodak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000235:genetics; D008010:Lichen Planus / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors
chemical_list: D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains; C508422:HLA-DRB1*11 antigen