title: Clinicopathological and prognostic significance of circulating tumor cells in patients with gastric cancer: a meta-analysis.
abstract: The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane database, the Science citation index, the CNKI database and the references of relevant studies were systematically searched (up to November, 2013). Using the random-effect model, the meta-analysis was completed with odds ratio (OR), risk ratio, hazard ratio (HR) and 95% confidence intervals (CI) as effect values. Twenty-six studies containing 2,566 patients with GC were analyzed. The overall analysis showed that the incidence difference of tumor cells (CTCs/DTCs) was significant when comparing the stage I/II group to the stage III/IV group (OR = 0.36, CI [0.23, 0.56]), the Lauren diffuse group to the intestinal group (OR = 2.06, CI [1.06, 4.00]), the poorly differentiated group to the well/moderate group (OR = 1.65, CI [1.10, 2.50]), the lymphatic involvement positive group to the positive group (OR = 2.92, CI [1.00, 8.55]). The detection of CTCs/DTCs was significantly related with the disease-free survival of patients (HR = 3.42, CI [2.39, 4.91]) and the detection of CTCs in peripheral blood was significantly related with the overall survival of patients (HR = 2.13, CI [1.13, 4.03]). Our meta-analysis indicates that detection of CTCs/DTCs is associated with prognosis for patients with GC and thus could act as a basis for GC staging.
authors.affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Heping District, Shenyang City, People's Republic of China.
authors.forename: Xuanzhang
authors.initials: X
authors.lastname: Huang
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Jingxu
authors.initials: J
authors.lastname: Sun
authors.forename: Xiaowan
authors.initials: X
authors.lastname: Chen
authors.forename: Yongxi
authors.initials: Y
authors.lastname: Song
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Huimian
authors.initials: H
authors.lastname: Xu
authors.forename: Zhenning
authors.initials: Z
authors.lastname: Wang
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*
keywords: circulating tumor cells; clinicopathological characteristics; gastric cancer; meta-analysis; prognosis