title: Maintenance tocolysis with oral micronized progesterone for prevention of preterm birth after arrested preterm labor.
abstract: OBJECTIVE
  To evaluate the efficacy of maintenance therapy with oral micronized progesterone (OMP) for prolongation of pregnancy in cases of arrested preterm labor.
  
  
  METHODS
  Ninety women at 24-34weeks of singleton pregnancy with intact membranes and arrested preterm labor were randomly allocated to receive OMP (n=45) or placebo (n=45) daily until 37weeks or delivery, whichever was earlier. Outcome parameters were compared using Student t test, χ(2) test, Fisher exact test, and log-rank χ(2) test.
  
  
  RESULTS
  OMP significantly prolonged the latency period (33.29±22.16 vs 23.07±15.42days; P=0.013). Log-rank analysis revealed a significant difference in mean time to delivery between the 2 groups (P=0.014). There were significantly fewer preterm births (33% vs 58%; P=0.034) and low birth weight neonates (37% vs 64%; P=0.017), and significantly higher mean birth weight (2.44±0.58 vs 2.14±0.47kg; P=0.009) in the OMP group. Perinatal outcomes and adverse effects were similar in the 2 groups.
  
  
  CONCLUSIONS
  Maintenance tocolysis with OMP significantly prolonged pregnancy and decreased the number of preterm births. Clinical Trial Registry of India: CTRI/2011/10/002043.
authors.affiliation: Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India. Electronic address: manjuchoudhary04lhmc@gmail.com.
authors.forename: Manju
authors.initials: M
authors.lastname: Choudhary
authors.affiliation: Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Suneja
authors.affiliation: Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.
authors.forename: Neelam B
authors.initials: NB
authors.lastname: Vaid
authors.affiliation: Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Guleria
authors.affiliation: Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.
authors.forename: M M A
authors.initials: MM
authors.lastname: Faridi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D011247:Pregnancy; D047928:Premature Birth / Q000517:prevention & control*; D011374:Progesterone / Q000008:administration & dosage*; D011372:Progestins / Q000008:administration & dosage*; D015145:Tocolysis / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011372:Progestins; D011374:Progesterone
keywords: Maintenance tocolysis; Oral micronized progesterone; Preterm labor