title: Cranial imaging findings in dengue virus infection.
abstract: BACKGROUND
  The aim of this study is to evaluate cranial CT or MRI changes in dengue encephalitis and their correlation with clinical and biochemical findings.
  
  
  METHODS
  Twenty-one serologically confirmed patients with dengue with altered sensorium were included who underwent MRI (20)/CT (1) scan study. Their clinical details including seizure, hypotension, bleeding diathesis, focal neurologic deficit, and Glasgow Coma Scale (GCS) score were noted. Blood counts, hematocrit, renal and liver function tests, electrolytes, cerebrospinal fluid (CSF) and ECG were done. MRI findings on T1, T2, FLAIR, DWI and T1 gadolinium contrast were noted.
  
  
  RESULTS
  The median age of the patients was 30 (5-69) years and 5 were females. MRI was abnormal in 9(45%) and CT scan in 1 patient with dengue shock syndrome revealed cerebellar and subdural hematoma. The MRI lesions were in thalamic and basal ganglia in 3, focal cortical areas in 3, white mater in 2 and meningeal enhancement in 3 patients. Seven of these patients had CSF pleocytosis. The presence of abnormal imaging was not related to outcome. One patient died, 1 was bed ridden and 19 had complete recovery on discharge.
  
  
  CONCLUSIONS
  Cranial imaging reveals nonspecific changes and is not related to hematological and biochemical changes or outcome.
authors.affiliation: Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.
authors.forename: Sanjeev Kumar
authors.initials: SK
authors.lastname: Bhoi
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.
authors.forename: Suprava
authors.initials: S
authors.lastname: Naik
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.
authors.forename: Rajendra Vishnu
authors.initials: RV
authors.lastname: Phadke
authors.affiliation: Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India. Electronic address: jayanteek@yahoo.com.
authors.forename: Jayantee
authors.initials: J
authors.lastname: Kalita
authors.affiliation: Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.
authors.forename: Usha Kant
authors.initials: UK
authors.lastname: Misra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002675:Child, Preschool; D003715:Dengue / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D004660:Encephalitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007964:Leukocytosis / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D063189:Symptom Assessment; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Basal ganglia; Computed tomography; Dengue encephalitis; Dengue encephalopathy; Magnetic resonance imaging; Thalamic lesion