title: Secondary Acute Lymphoblastic Leukemia after Hodgkin's Lymphoma or a Coincidental Association of Two Hematological Malignancies?
abstract: Secondary acute lymphoblastic leukaemia (sALL), defined as acute lymphoblastic leukaemia following another malignancy, irrespective of previous treatment, is a rare disease, and its biological characteristics have not been accurately described. We report the case of a 24-year old patient followed for Hodgkin's lymphoma at our clinic, who develops and is diagnosed, less than a year after obtaining complete remission, as having pro-B acute lymphoblastic leukaemia This case has been a real diagnostic and treatment challenge, as sALL following another haematological malignancy is quite rare.
  
  
  CONCLUSIONS
  It is necessary to better identify the prognostic factors of haematological malignancies in order to prevent the appearance of sALL.
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Tevet
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Cornel
authors.initials: C
authors.lastname: Dragan
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Carmen
authors.initials: C
authors.lastname: Saguna
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Doina
authors.initials: D
authors.lastname: Barbu
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Anca Roxana
authors.initials: AR
authors.lastname: Lupu
keywords: 11q23 mutation; Hodgkin's lymphoma; alkilating agents; immunophenotyping; prognostic factors; secondary acute leukaemia