title: Engineered proteins for bioelectrochemistry.
abstract: It is only in the past two decades that excellent protein engineering tools have begun to meet parallel advances in materials chemistry, nanofabrication, and electronics. This is revealing scenarios from which synthetic enzymes can emerge, which were previously impossible, as well as interfaces with novel electrode materials. That means the control of the protein structure, electron transport pathway, and electrode surface can usher us into a new era of bioelectrochemistry. This article reviews the principle of electron transfer (ET) and considers how its application at the electrode, within the protein, and at a redox group is directing key advances in the understanding of protein structure to create systems that exhibit better efficiency and unique bioelectrochemistry.
authors.affiliation: Institute of Biotechnology, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1QT United Kingdom; email: lisa.hall@biotech.cam.ac.uk.
authors.forename: Muhammad Safwan
authors.initials: MS
authors.lastname: Akram
authors.forename: Jawad
authors.initials: J
authors.lastname: Ur Rehman
authors.forename: Elizabeth A H
authors.initials: EA
authors.lastname: Hall
mesh_terms: D000818:Animals; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D006801:Humans; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: bioelectrochemistry; electron transfer; protein electrochemistry; protein engineering