title: rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese.
abstract: OBJECTIVE
  Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese.
  
  
  METHODS
  749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed.
  
  
  RESULTS
  Among the six candidate variants, only rs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa (ORrecessive= 1.56, p=0.006); and rs7837328 (A) was associated with PCa (ORdominant= 1.38, p=0.042/ORrecessive=1.99, p=0.003). Moreover, we observed a cumulative effects between them (ptrend=2.58?10-5). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) (page=0.046, Ptumorstage =0.048).
  
  
  CONCLUSIONS
  rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.
authors.affiliation: Department of Public Health, Harbin Medical University, Harbin, China E-mail : binyouwang@foxmail.com; yang_ze@sina.com.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Kuo
authors.initials: K
authors.lastname: Yang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Yi-Ge
authors.initials: YG
authors.lastname: Yang
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Chen
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Fu
authors.forename: Chen-Guang
authors.initials: CG
authors.lastname: Zheng
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Xiao-Qiu
authors.initials: XQ
authors.lastname: Mu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Shi
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
authors.forename: Bin-You
authors.initials: BY
authors.lastname: Wang
mesh_terms: D002681:China / Q000453:epidemiology; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012306:Risk; D012307:Risk Factors