title: Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis.
abstract: Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.
authors.affiliation: Department of Chemistry, Aarhus University, Aarhus, C 8000, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Denmark.
authors.forename: Kaja
authors.initials: K
authors.lastname: Zuwala
authors.forename: Anton A A
authors.initials: AA
authors.lastname: Smith
authors.forename: Almar
authors.initials: A
authors.lastname: Postma
authors.forename: Carlos
authors.initials: C
authors.lastname: Guerrero-Sanchez
authors.forename: Pau
authors.initials: P
authors.lastname: Ruiz-Sanchis
authors.forename: Jesper
authors.initials: J
authors.lastname: Melchjorsen
authors.forename: Martin
authors.initials: M
authors.lastname: Tolstrup
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D063566:Biodegradable Plastics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015215:Zidovudine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D063566:Biodegradable Plastics; D004337:Drug Carriers; D011355:Prodrugs; D015215:Zidovudine
keywords: HIV; drug delivery; polymers; prodrugs