title: A highly efficient Cu-catalyzed S-transfer reaction: from amine to sulfide.
abstract: A highly efficient Cu-catalyzed dual C-S bonds formation reaction, proceeding in alcohol and water under air, is reported, in which inodorous stable Na2S2O3 is used as a sulfurating reagent. This powerful strategy provides a practical and efficient approach to construct thioethers, using readily available aromatic amines and alkyl halides as starting materials. Sensitive and synthetic useful functional groups could be tolerated. Furthermore, pharmaceuticals, glucose, an amino acid, and a chiral ligand are successfully furnished by this late-stage sulfuration strategy.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University , Shanghai 200062, P. R. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.forename: Jiahua
authors.initials: J
authors.lastname: Pu
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry; D013885:Thiosulfates / Q000737:chemistry
chemical_list: D000588:Amines; D013440:Sulfides; D013885:Thiosulfates; D003300:Copper; C017717:sodium thiosulfate