title: Axon regeneration in C. elegans.
abstract: Single axon transection by laser surgery has made Caenorhabditis elegans a new model for axon regeneration. Multiple conserved molecular signaling modules have been discovered through powerful genetic screening. In vivo imaging with single cell and axon resolution has revealed unprecedented cellular dynamics in regenerating axons. Information from C. elegans has greatly expanded our knowledge of the molecular and cellular mechanisms of axon regeneration.
authors.affiliation: Department of Genetics and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, CT 06520, United States. Electronic address: marc.hammarlund@yale.edu.
authors.forename: Marc
authors.initials: M
authors.lastname: Hammarlund
authors.affiliation: Section of Neurobiology and Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, CA 92093, United States. Electronic address: yijin@ucsd.edu.
authors.forename: Yishi
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D009416:Nerve Regeneration / Q000502:physiology*; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins