title: The transmembrane channel-like protein family and human papillomaviruses: Insights into epidermodysplasia verruciformis and progression to squamous cell carcinoma.
abstract: Epidermodysplasia verruciformis(EV) is a rare genodermatosis characterized by increased sensitivity to infection by the β-subtype of human papillomaviruses (β-HPVs), causing persistent, tinea versicolor-like dermal lesions. In a majority of affected individuals, these macular lesions progress to invasive cutaneous squamous cell carcinoma (CSCC) in sun-exposed areas. While mutations in transmembrane channel-like 6 (TMC6 / EVER1) and 8 (TMC8 / EVER2) have been causally linked to EV, their molecular functions are unclear. It is likely that their protective effects involve regulation of the β-HPV life cycle, host keratinocyte apoptosis vs. survival balance and/or T-cell interaction with infected host cells.
authors.affiliation: Laboratory of Experimental Medicine; John A. Burns School of Medicine; Honolulu, HI USA ; Department of Cell and Molecular Biology; John A. Burns School of Medicine; Honolulu, HI USA.
authors.forename: Jaime S
authors.initials: JS
authors.lastname: Horton
authors.affiliation: Laboratory of Experimental Medicine; John A. Burns School of Medicine; Honolulu, HI USA ; Department of Cell and Molecular Biology; John A. Burns School of Medicine; Honolulu, HI USA ; Chaminade University; Honolulu, HI USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Stokes
keywords: EVER1; EVER2; Epidermodysplasia verruciformis; TMC6; TMC8; cutaneous squamous cell carcinoma; papillomavirus