title: Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis.
abstract: Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.
authors.affiliation: Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Oguchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Funahashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sugino
authors.forename: Naoki
authors.initials: N
authors.lastname: Kawamorita
authors.forename: Mahendra P
authors.initials: MP
authors.lastname: Kashyap
authors.forename: Michael B
authors.initials: MB
authors.lastname: Chancellor
authors.forename: Pradeep
authors.initials: P
authors.lastname: Tyagi
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D018856:Cystitis, Interstitial / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D059411:Lower Urinary Tract Symptoms / Q000503:physiopathology; D020932:Nerve Growth Factor / Q000378:metabolism; D009473:Neuronal Plasticity; D011788:Quality of Life; D018689:Sensory System Agents / Q000494:pharmacology*; D035703:Therapies, Investigational; D014521:Urethra / Q000294:innervation / Q000503:physiopathology; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D018689:Sensory System Agents; D020932:Nerve Growth Factor
keywords: afferent pathway; bladder pain syndrome; cytokine; interstitial cystitis; nerve growth factor