title: Effect of autologous fat injection on lower eyelid position.
abstract: OBJECTIVE
  To evaluate the effect of autologous periorbital fat injections on lower eyelid position.
  
  
  METHODS
  Retrospective review of patients treated with autologous periorbital (malar/eyelid tear trough) fat injections for aesthetic purposes by a single surgeon (S.N.) between March 2007 and June 2011. The primary outcome, lower eyelid position as defined by marginal reflex distance 2 and inferior scleral show, was measured by standardizing and comparing pretreatment and posttreatment follow-up digital photos. Photographs were randomized and measured by 2 masked investigators.
  
  
  RESULTS
  Seventy patients (5 male; mean age, 53; range, 33 to 77 years) were treated with autologous fat injections to the malar and lower eyelid tear trough for aesthetic purposes. A mean decrease in marginal reflex distance 2 of 0.5 mm in both OS and OD was found when pre- and posttreatment measurements were compared. Primary and secondary mean follow-up period was at 117 and 316 days, respectively. The effect of the autologous periorbital fat injection was not diminished (n=21) between follow-up periods. A mean change in scleral show of 0.5 mm was found when pre- and posttreatment measurements were compared. The overall mean follow-up period for scleral show was 125 days. Minor complications occurred in 7% (n=5) of patients who had postinjection subcutaneous induration.
  
  
  CONCLUSIONS
  Autologous fat injections are well tolerated and have potential to be an effective adjuvant or primary treatment for mild lower eyelid retraction.
authors.affiliation: *Department of Ophthalmology, The University of Washington, Seattle, Washington; †Rocky Mountain Eye Center, Butte, Montana; ‡Naficy Plastic Surgery and Rejuvenation Center, Kirkland, Washington; and §Department of Otolaryngology Head and Neck Surgery, The University of Washington, Seattle, Washington, U.S.A.
authors.forename: Thao Phuong
authors.initials: TP
authors.lastname: Le
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Peckinpaugh
authors.forename: Sam
authors.initials: S
authors.lastname: Naficy
authors.forename: A J
authors.initials: AJ
authors.lastname: Amadi
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D004954:Esthetics; D005141:Eyelid Diseases / Q000601:surgery*; D005143:Eyelids / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015361:Rhytidoplasty; D014182:Transplantation, Autologous