title: Phenotype characteristics of patients with colonic serrated polyposis syndrome: a study of 23 cases.
abstract: BACKGROUND
  Serrated polyposis syndrome (SPS) is a rare entity characterized by the presence of multiple hyperplastic polyps in the colon and an increased risk of presentation and development of colorectal cancer (CRC).
  
  
  OBJECTIVE
  To evaluate the clinical and phenotypical characteristics of patients that present one of the 3 WHO criteria for the diagnosis of SPS diagnosed and treated a tour hospital.
  
  
  METHODS
  Patients with the diagnosis of SPS during 2005-2012 were revised; 24.208 colonoscopies were performed during this period. Age, sex, family history of CRC (APC/MYH), proximal/mixed/distal phenotype, indication for colonoscopy, number, size, location of the hyperplastic polyps, presence of mixed/adenomatous polyps, CRCI, follow-up and endoscopio/surgical treatment.
  
  
  RESULTS
  A total of 23 cases were included (19 male). The median age was 51. A total of 34% had a prior family history of CRC or polpyps. Distal phenotype was more frequent (48%). Another 73% presented synchronous adenomatous polyps, and 26% a CRC. A total of 57% were asymptomatic. Surgery was performed in 9 cases (6 for cancer and 3 for polyposis), and 14 were treated by polypectomy and observation. Eleven patients (47%) presented recurrent/persistent lesions after initial surgical/endoscopic treatment.
  
  
  CONCLUSIONS
  SPS is an heterogeneous syndrome that is variable in the type, size, distribution and number of polyps, and is more common in male smokers with a distal phenotype. The majority of patients also present synchronous adenomatous polyps. These patients require an organized multidisciplinary evaluation.
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España.
authors.forename: Garazi
authors.initials: G
authors.lastname: Elorza
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España; Servicio de Gastroenterología, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España; Servicio de Anatomía Patológica, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España. Electronic address: josemaria.enriqueznavascues@osakidetza.net.
authors.forename: José M
authors.initials: JM
authors.lastname: Enríquez-Navascués
authors.affiliation: Servicio de Gastroenterología, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Bujanda
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España.
authors.forename: Mikel
authors.initials: M
authors.lastname: Larzábal
authors.affiliation: Servicio de Gastroenterología, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España.
authors.forename: Inés
authors.initials: I
authors.lastname: Gil Lasa
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario Donostia, UPV-EHU, San Sebastián, España.
authors.forename: Laura
authors.initials: L
authors.lastname: Martí
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012189:Retrospective Studies; D013577:Syndrome; D055815:Young Adult
keywords: Fenotipo; Hyperplastic polyps; Phenotype; Polipos hiperplásicos; Poliposis serrada; Serrated polyposis; Serrated polyposis syndrome; Síndrome de poliposis serrada