title: Mechanism and physiological significance of programmed replication termination.
abstract: Replication forks in both prokaryotic and eukaryotic systems pause at random sites due to depletion of dNTP pools, DNA damage, tight binding nonhistone proteins or unusual DNA sequences and/or structures, in a mostly non-polar fashion. However, there is also physiologically programmed replication termination at sequence-specific authentic replication termini. Here, the structure and functions of programmed replication termini, their mechanism of action and their diverse physiological functions in prokaryotes and eukaryotes have been reviewed.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States. Electronic address: bastia@musc.edu.
authors.forename: Deepak
authors.initials: D
authors.lastname: Bastia
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States.
authors.forename: Shamsu
authors.initials: S
authors.lastname: Zaman
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D001419:Bacteria / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D001483:Base Sequence; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics; D020868:Gene Silencing; D006801:Humans; D008958:Models, Molecular; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D029701:Saccharomyces cerevisiae Proteins
keywords: Crystal structure; Gene silencing; Recombination; Replication termination; Replicative aging; Terminator protein