title: The protective effect of CD40 ligand-CD40 signalling is limited during the early phase of Plasmodium infection.
abstract: γδ T cells are essential for eliminating Plasmodium berghei XAT. Because administration of the agonistic anti-CD40 antibody can induce elimination of P. berghei XAT parasites in γδ T cell-deficient mice, we considered that γδ T cells might activate dendritic cells via CD40 signalling during infection. Here we report that administration of the anti-CD40 antibody to γδ T cell-deficient mice 3-10 days post-P. berghei XAT infection could eliminate the parasites. Our data suggest that dendritic cell activation via γδ T cells expressing CD40 ligand is critical during the early phase of infection.
authors.affiliation: Departments of Infectious Diseases, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Inoue
authors.affiliation: Departments of Infectious Diseases, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Niikura
authors.affiliation: Departments of Infectious Diseases, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Departments of Infectious Diseases, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Mineo
authors.affiliation: Laboratory of Parasitology, School of Life and Environmental Science, Azabu University, 17-71, Fuchinobe 1, Sagamihara-city, Kanagawa 252-0206, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawakami
authors.affiliation: Yamazaki Gakuen University, 7-2, Minami-osawa 4, Hachiohji-city, Tokyo 192-0364, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Uchida
authors.affiliation: Laboratory Medicine, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohnishi
authors.affiliation: Departments of Infectious Diseases, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kamiya
authors.affiliation: Laboratory Medicine, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Departments of Infectious Diseases, Kyorin University School of Medicine, 20-2, Shinkawa 6, Mitaka-city, Tokyo 181-8611, Japan. Electronic address: fumfum@ks.kyorin-u.ac.jp.
authors.forename: Fumie
authors.initials: F
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D019013:CD40 Antigens / Q000037:antagonists & inhibitors / Q000378:metabolism*; D023201:CD40 Ligand / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010962:Plasmodium berghei / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal; D019013:CD40 Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta; D023201:CD40 Ligand
keywords: CD40 ligand; CD40 signalling; dendritic cells; malaria; γδ T cells