title: Effect of simvastatin treatment on plasma visfatin levels in obese women.
abstract: OBJECTIVE
  Obesity is one of the major concerns in the world currently, its prejudicial effect is exerted by proteins secreted by adipose tissue, among them visfatin was demonstrated to be related with BMI and cardiovascular diseases. The HMG-CoA reductase inhibitors are known to minimize the cardiovascular risk in hyperlipidemic patients and recently the discovery of various pleiotropic effects has made the statins evidencing among others anti-inflammatory effect. Our objective in this study was to determinate if simvastatin treatment may modulate visfatin levels in obese women without any other metabolic disorder.
  
  
  METHODS
  We recruited 25 obese women without any other metabolic disorder and treated with simvastatin for 6 weeks 20 mg/day.
  
  
  RESULTS
  The levels of plasma visfatin were similar before and after treatment (22 ± 20 versus 27 ± 14 ng/mL, p > 0.05) and correlated with BMI before treatment (p = 0.001). We also found correlations among visfatin and insulin levels (p = 0.015) and HOMA-IR (p = 0.025) only after treatment.
  
  
  CONCLUSIONS
  These findings suggest that visfatin is not modulated by simvastatin treatment in this group but the treatment may interfere on the relation among visfatin, BMI, insulin and HOMA-IR.
authors.affiliation: Núcleo de Pós-Graduação e Pesquisa - Santa Casa de Belo Horizonte , Belo Horizonte, MG , Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Petreanu
authors.forename: N
authors.initials: N
authors.lastname: Eleuterio
authors.forename: A A
authors.initials: AA
authors.lastname: Bosco
authors.forename: V C
authors.initials: VC
authors.lastname: Sandrim
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000188:drug therapy*; D019821:Simvastatin / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D016207:Cytokines; D000960:Hypolipidemic Agents; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D019821:Simvastatin; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: BMI; insulin; obesity; simvastatin; visfatin