title: Coexistence of Extended Spectrum Beta-Lactamases, AmpC Beta-Lactamases and Metallo-Beta-Lactamases in Acinetobacter baumannii from burns patients: a report from a tertiary care centre of India.
abstract: Multidrug-resistant Acinetobacter baumanii is a major pathogen encountered in pyogenic infections, especially from burns patients in hospital settings. Often there is also coexistence of multiple beta-lactamase enzymes responsible for beta-lactam resistance in a single isolate, which further complicates treatment options. We conducted a study on burn wound pus samples obtained from the burns unit of our hospital. Phenotypic tests were used to determine the Extended Spectrum Beta-Lactamase, AmpC Beta-Lactamase and Metallo-Beta-Lactamase producing status of the isolates. Almost half of the samples from the burn wounds yielded Acinetobacter baumanii as the predominant pathogen (54.05%). Coexistence of the three resistance mechanisms was seen in 25 of the 100 (25%) isolates of Acinetobacter baumanii. This study emphasizes the need for the detection of isolates that produce these enzymes to avoid therapeutic failures and nosocomial outbreaks.
authors.affiliation: Government Medical College Hospital, Sector 32, Chandigarh, India Department of Microbiology.
authors.forename: V
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Government Medical College Hospital, Sector 32, Chandigarh, India Department of Microbiology.
authors.forename: R
authors.initials: R
authors.lastname: Garg
authors.affiliation: Government Medical College Hospital, Sector 32, Chandigarh, India Department of Microbiology.
authors.forename: S
authors.initials: S
authors.lastname: Garg
authors.affiliation: Government Medical College Hospital, Sector 32, Chandigarh, India Department of Microbiology.
authors.forename: J
authors.initials: J
authors.lastname: Chander
authors.affiliation: Department of Surgery.
authors.forename: A K
authors.initials: AK
authors.lastname: Attri
keywords: Acinetobacter baumanii; AmpC Beta-Lactamase; Extended Spectrum Beta-Lactamase; Metallo-Beta-Lactamase