title: Associations of fat mass and fat distribution with bone mineral density in Chinese obese population.
abstract: The purpose of the study was to investigate the associations of fat mass (FM) and fat distribution with bone mineral density (BMD) in Chinese obese population. Three hundred and forty-seven Chinese obese females and 339 males aged 20-39 years were analyzed. Lean mass (LM), FM, percent body fat (%BF), android FM, gynoid FM, and total and regional BMD were measured using dual-energy X-ray absorptiometry. Fat distribution was assessed by android-to-gynoid FM ratio (AOI). As a result, increased central body fat had an inverse association with total and leg BMD in females but not in males. Increased FM and %BF were positively associated with arm, trunk, and pelvic BMD in Chinese obese females. Increased FM was positively associated with total, rib, and trunk BMD in Chinese obese males. The results remained almost unchanged after adjusting for LM, and LM was significantly positively associated with spine BMD in female group. FM was positively associated with trunk BMD in male group after adjusting for LM. AOI was inversely associated with total and leg BMD, and %BF was positively associated with arm, trunk, and pelvic BMD when replacing FM with %BF in female group. The results remained almost unchanged after adjusting for LM. There is no significant association in male group when replacing FM with %BF. In conclusion, our findings demonstrate that there are different associations of FM and fat distribution with BMD, and AOI has a negative association with BMD.
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Shaonan
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Probability and Statistics, School of Mathematical Sciences, Peking University, Beijing, China.
authors.forename: Jiayin
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Yazeng
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
authors.forename: Di
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Dual Energy X-ray Absorptiometry (DEXA), Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China. Electronic address: orthopedicszj@gmail.com.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Ying
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D050218:Body Fat Distribution / Q000379:methods; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors; D013223:Statistics as Topic
keywords: Bone mineral density; fat distribution; fat mass; obesity