title: Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid.
abstract: Bone cement is widely used in surgical treatments for the fixation for orthopaedic devices. Subsequently, 2-3% of patients undergoing these procedures develop infections that are both a major health risk for patients and a cost for the health service providers; this is also aggravated by the fact that antibiotics are losing efficacy because of the rising resistance of microorganisms to these substances. In this study, oleic acid capped silver nanoparticles (NP) were encapsulated into Poly(methyl methacrylate) (PMMA)-based bone cement samples at various ratios. Antimicrobial activity against Methicillin Resistant Staphylococcus aureus, S. aureus, Staphylococcus epidermidis, Acinetobacter baumannii was exhibited at NP concentrations as low as 0.05% (w/w). Furthermore, the mechanical properties and cytotoxicity of the bone cement containing these NP were assessed to guarantee that such material is safe to be used in orthopaedic surgical practice.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, Wales, UK; Institute of Mechanical and Manufacturing Engineering, School of Engineering, Cardiff University, Cardiff CF24 3AA, Wales, UK; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors.forename: Polina
authors.initials: P
authors.lastname: Prokopovich
authors.forename: Mathias
authors.initials: M
authors.lastname: Köbrick
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Brousseau
authors.forename: Stefano
authors.initials: S
authors.lastname: Perni
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006094:Gram-Positive Bacteria / Q000254:growth & development*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D019301:Oleic Acid / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D001843:Bone Cements; D019301:Oleic Acid
keywords: PMMA; antimicrobial; bone cement; nanoindentation; silver nanoparticles