title: Innate-type and acquired-type allergy regulated by IL-33.
abstract: We propose two types of allergic response: IgE-dependent and IgE-independent, and designate these as 'acquired-type allergy' and 'innate-type allergy', respectively. IL-33 stimulates both innate (basophils, mast cells, or group 2 innate lymphoid cells) and acquired (Th2 cells) allergy-related cells to induce and/or augment Th2 cytokine production, which leads to eosinophilic inflammation in vivo. Thus, IL-33 is an essential regulator for both 'innate-type allergy' and 'acquired-type allergy', and might be an attractive therapeutic target for allergic diseases.
authors.affiliation: Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yoshimoto
authors.affiliation: Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Matsushita
mesh_terms: D056704:Adaptive Immunity; D000485:Allergens / Q000276:immunology; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D007113:Immunity, Innate; D000067596:Interleukin-33; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000485:Allergens; C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins