title: Tumor acquisition for biomarker research in lung cancer.
abstract: The biopsy collection data from two lung cancer trials that required fresh tumor samples be obtained for microarray analysis were reviewed. In the trial for advanced disease, microarray data were obtained on 50 patient samples, giving an overall success rate of 60.2%. The majority of the specimens were obtained through CT-guided lung biopsies (N = 30). In the trial for early-stage patients, 28 tissue specimens were collected from excess tumor after surgical resection with a success rate of 85.7%. This tissue procurement program documents the feasibility in obtaining fresh tumor specimens prospectively that could be used for molecular testing.
authors.affiliation: 1Duke Cancer Institute, Durham, North Carolina, USA;
authors.forename: Marvaretta
authors.initials: M
authors.lastname: Stevenson
authors.forename: Jared
authors.initials: J
authors.lastname: Christensen
authors.forename: Debra
authors.initials: D
authors.lastname: Shoemaker
authors.forename: Traci
authors.initials: T
authors.lastname: Foster
authors.forename: William T
authors.initials: WT
authors.lastname: Barry
authors.forename: Betty C
authors.initials: BC
authors.lastname: Tong
authors.forename: Momen
authors.initials: M
authors.lastname: Wahidi
authors.forename: Scott
authors.initials: S
authors.lastname: Shofer
authors.forename: Michael
authors.initials: M
authors.lastname: Datto
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Ginsburg
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Crawford
authors.forename: Thomas
authors.initials: T
authors.lastname: D'Amico
authors.forename: Neal
authors.initials: N
authors.lastname: Ready
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D002986:Clinical Trials as Topic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D012313:RNA
keywords: Bioinformatics; Gene profiling; Lung cancer