title: Regulation of p63 protein stability via ubiquitin-proteasome pathway.
abstract: The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds of proteins are involved in regulation of p63 protein stability. These regulators are responsive to diverse extracellular signaling, resulting in changes of the p63 protein levels and impacting different biological processes.
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Li
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors.forename: Zhi-Xiong
authors.initials: ZX
authors.lastname: Xiao
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D010750:Phosphoproteins; D046988:Proteasome Endopeptidase Complex; D015398:Signal Transduction; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin
chemical_list: D010750:Phosphoproteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; C486419:Trp63 protein, mouse; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex