title: TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery.
abstract: Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.
authors.affiliation: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China. xqyu@scu.edu.cn ji_zhang@163.com.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Yi
authors.forename: Xing-Chi
authors.initials: XC
authors.lastname: Yu
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Qing-Ying
authors.initials: QY
authors.lastname: Yu
authors.forename: Xue-Dong
authors.initials: XD
authors.lastname: Zhou
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000737:chemistry; D005822:Genetic Vectors / Q000235:genetics / Q000378:metabolism; D057809:HEK293 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D011094:Polyethyleneimine / Q000737:chemistry; D013329:Structure-Activity Relationship; D014162:Transfection
chemical_list: D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D006571:Heterocyclic Compounds; C075712:1,4,7-triazacyclononane; D011094:Polyethyleneimine; D004247:DNA