title: Proton pump inhibitors and functional decline in older adults discharged from acute care hospitals.
abstract: OBJECTIVE
  To investigate the relationship between use of proton pump inhibitors (PPIs) and incident dependency in older adults discharged from acute care hospitals.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Eleven geriatric and internal medicine acute care wards located throughout Italy.
  
  
  METHODS
  Individuals (mean age 79.2 ± 5.5) who were not completely dependent at the time of discharge from participating wards (N = 401).
  
  
  METHODS
  The outcome of interest was the loss of at least one basic activity of daily living (ADL) from discharge to the end of follow-up (12 months). The relationship between PPI use and functional decline was investigated using logistic regression analysis before and after propensity score matching.
  
  
  RESULTS
  Use of PPIs was significantly associated with functional decline before (odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.17-2.60) and after propensity score matching (OR = 2.44; 95% CI = 1.36-4.41). Other predictors of functional decline were hypoalbuminemia (OR = 3.10, 95% CI = 1.36-7.10 before matching, OR = 2.81, 95% CI = 1.09-7.77 after matching) and cognitive impairment (OR = 4.08, 95% CI = 1.63-10.2 before matching, OR = 6.35, 95% CI = 1.70-24.0 after matching).
  
  
  CONCLUSIONS
  Use of PPIs is associated with functional decline during 12 months of follow-up in older adults discharged from acute care hospitals.
authors.affiliation: Unit of Geriatric Pharmacoepidemiology, Research Hospital of Cosenza, Italian National Research Centre on Aging, Cosenza, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Corsonello
authors.forename: Marcello
authors.initials: M
authors.lastname: Maggio
authors.forename: Sergio
authors.initials: S
authors.lastname: Fusco
authors.forename: Bakhita
authors.initials: B
authors.lastname: Adamo
authors.forename: Diana
authors.initials: D
authors.lastname: Amantea
authors.forename: Claudio
authors.initials: C
authors.lastname: Pedone
authors.forename: Sabrina
authors.initials: S
authors.lastname: Garasto
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ceda
authors.forename: Francesco
authors.initials: F
authors.lastname: Corica
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Lattanzio
authors.forename: Raffaele
authors.initials: R
authors.lastname: Antonelli Incalzi
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D010351:Patient Discharge; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*
chemical_list: D054328:Proton Pump Inhibitors
keywords: activities of daily living; elderly; functional decline; hospital; proton pump inhibitors