title: Steroid treatment of eosinophilic esophagitis in adults.
abstract: Topical steroid therapy has been used to treat eosinophilic esophagitis (EoE) for more than 15 years. We review the treatment trials of topical steroid therapy in adult patients with EoE. Currently, there is no commercially available preparation designed to deliver the steroid to the esophagus. Current regimens consist of swallowing steroid preparations designed for inhalation treatment for asthma. In the short term, steroids are associated with an approximately 15% to 25% incidence of asymptomatic esophageal candidiasis, but otherwise appear to be well tolerated.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic School of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: alexander.jeffrey14@mayo.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Alexander
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D002986:Clinical Trials as Topic; D057765:Eosinophilic Esophagitis / Q000188:drug therapy*; D006801:Humans; D060046:Maintenance Chemotherapy
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Comparator trials; Issues in steroid treatment of eosinophilic esophagitis; Maintenance trials; Open-label trials; Placebo-controlled trials