title: Evaluation of spatial memory and locomotor activity during hypercortisolism induced by the administration of dexamethasone in adult male rats.
abstract: In neurosurgery practice glucocorticoids are commonly used. Steroids may have central nervous system side effects affecting whole body, including steroid-induced mental agitation and psychosis. In experimental and clinical studies conducted by using dexamethasone (DEX), it has been reported that DEX adversely affects learning and memory skills. Unfortunately, there are yet no clinically accepted clinical approaches to prevent DEX-induced cognitive dysfunction. In this experimental study it was aimed to investigate the effect of chronic DEX administration on learning-memory and locomotor behaviors in adult male Sprague Dawley rats. In addition, it was also aimed to explore the potential favorable contribution of melatonin (MEL) and vitamin C (Vit C) having antioxidant and neuroprotective properties to the effects of DEX on learning-memory and locomotor behaviors. For this purpose, rats were injected 10mg/kg DEX intraperitoneally, both alone and in combination with MEL (40 mg/kg) and Vit C (100mg/kg), for 9 days, and the animals were tested using the radial arm maze and open field apparatus. The test results revealed that DEX caused a significant decrease in spatial memory and locomotor activities and MEL and Vit C failed to reverse losses in these activities. Furthermore, DEX led to a gradual weight loss that reached 30% of the initial weight at 9th day of the injection. DEX administration causes a generalized loss of behavioral activity of rats. Experimental studies devised to investigate effects of DEX should take into account this DEX-induced generalized behavioral loss when assessing the effects of DEX on learning and memory skills. This article is part of a Special Issue entitled SI: Brain and Memory.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Dicle University, Yenişehir 21280, Diyarbakir, Turkey. Electronic address: kartaltevfik@hotmail.com.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Yılmaz
authors.affiliation: Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Öznur
authors.initials: Ö
authors.lastname: Gedikli
authors.affiliation: Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yildirim
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000139:chemically induced* / Q000150:complications*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D018680:Cholinergic Antagonists / Q000494:pharmacology; D003907:Dexamethasone / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005938:Glucocorticoids / Q000633:toxicity*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008550:Melatonin / Q000008:administration & dosage; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D000975:Antioxidants; D018680:Cholinergic Antagonists; D005938:Glucocorticoids; D003907:Dexamethasone; D012601:Scopolamine; D008550:Melatonin; D001205:Ascorbic Acid
keywords: Dexamethasone; Locomotor activity; Melatonin; Memory; Rat; Vitamin C