title: MicroRNAs in the control of metastatic bone disease.
abstract: Bone metastasis is a common and devastating complication of late-stage breast and prostate cancer. Complex interactions between tumor cells, bone cells, and a milieu of components in their microenvironment contribute to the osteolytic, osteoblastic, or mixed lesions present in patients with metastasis to bone. In the past decade microRNAs (miRNAs) have emerged as key players in cancer progression, but the importance of miRNAs in regulating cancer metastasis to bone is only now being appreciated. We emphasize here important concepts of bone biology and miRNAs in the context of breast and prostate cancer, and focus on recent advances that have improved our understanding of the role of specific miRNAs with direct involvement in metastatic bone disease.
authors.affiliation: Vermont Cancer Center and Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
authors.forename: Gillian
authors.initials: G
authors.lastname: Browne
authors.affiliation: Heisenberg-Group for Molecular Skeletal Biology, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Hanna
authors.initials: H
authors.lastname: Taipaleenmäki
authors.affiliation: Vermont Cancer Center and Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
authors.affiliation: Vermont Cancer Center and Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.affiliation: Vermont Cancer Center and Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, 05405, USA. Electronic address: Jane.Lian@med.uvm.edu.
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics* / Q000556:secondary*; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000150:complications / Q000235:genetics
chemical_list: D035683:MicroRNAs
keywords: bone metastasis; breast cancer; miRNA; osteolytic/osteoblastic disease; prostate cancer