title: Effect of human T-cell lymphotrophic virus type 1 (HTLV-1) in seropositive infertile women on intracytoplasmic sperm injection (ICSI) outcome.
abstract: BACKGROUND
  Human T-cell Lymphotrophic virus type 1 (HTLV-1) has infected more than 20 million people worldwide. Northeast of Iran, Mashhad, the capital of Razavi Khorasan Province, is endemic for HTLV-1 with a prevalence of 3% among general population.
  
  
  OBJECTIVE
  We evaluated the ICSI outcome in our program for (HTLV-1) serodiscordant couples (SDCs) with the female infected in comparison with control group.
  
  
  METHODS
  This study was performed between 2007 and 2011 in Novin Infertility Treatment Center (Mashhad, Iran). We examined 32 ICSI cycles of HTLV-1 infected women in comparison with an age matched control group (n=62). ICSI outcome was compared regarding fertilization rate (FR), embryo quality parameters, implantation rate (IR), clinical pregnancy rate (PR), and abortion rate (AR).
  
  
  RESULTS
  Fertilization (p=0.15), implantation (p=0.33), and pregnancy rate (p=0.12) were similar between the groups. No difference was found regarding the number of transferred embryos (on day 2 or 3) and cryopreserved embryos, multiple pregnancies, or abortion rates between the groups.
  
  
  CONCLUSIONS
  Our results suggest that the embryo quality and ICSI outcome are not affected by HTLV-1 infection in serodiscordant couples. The major finding of this study is that the outcome of ICSI in HIV-I-infected patients and seronegative controls is similar.
authors.affiliation: Novin Infertility Treatment Center, Mashhad, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Mansouri Torshizi
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Khalighi
authors.affiliation: Novin Infertility Treatment Center, Mashhad, Iran.
authors.forename: Mahla
authors.initials: M
authors.lastname: Fadavi Islam
authors.affiliation: Novin Infertility Treatment Center, Mashhad, Iran.
authors.forename: Rahele
authors.initials: R
authors.lastname: Aram
authors.affiliation: Novin Infertility Treatment Center, Mashhad, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Sabouri
authors.affiliation: Novin Infertility Treatment Center, Mashhad, Iran.
authors.forename: Hekmat
authors.initials: H
authors.lastname: Khalilifar
authors.affiliation: Novin Infertility Treatment Center, Mashhad, Iran. ; Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hesam
authors.initials: H
authors.lastname: Roustaee
keywords: HTLV-1; ICSI outcome; Infertile; Seropositive