title: Correlation between postprandial bile acids and body fat mass in healthy normal-weight subjects.
abstract: BACKGROUND
  Bile acids (BAs) play important roles in glucose regulation and energy homeostasis via G protein-coupled receptors, such as enteroendocrine L cell TGR5. The aim of the present study was to investigate the relationship between postprandial BA levels and body composition after ingestion of a standard test meal.
  
  
  METHODS
  Eleven healthy subjects of normal weight (body-mass index, 22.0 ± 1.6 kg/m(2) [mean ± SD]), ingested a 400-kcal test meal, and blood samples were obtained from them before ingestion and every 30 min for 120 min after ingestion. The BA fractions were measured with high-performance liquid chromatography. To evaluate body composition, body impedance analysis was performed 1h before ingestion of the test meal.
  
  
  RESULTS
  Concentrations of both total BA and total glycine-conjugated BA (GCBA) at 30, 60, 90, and 120 min after test-meal ingestion were significantly higher than those at baseline. The body-mass index was correlated with total GCBA at baseline. Moreover, body fat mass was correlated with total GCBA at 30 min (r=-0.688, P=0.019) and 60 min (r=-0.642, P=0.033) and with total BA at 30 min (r=-0.688, P=0.019) and 60 min (r=-0.642, P=0.033).
  
  
  CONCLUSIONS
  The postprandial BA response is inversely related with body fat mass in healthy subjects of normal weight.
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan. Electronic address: t-suzuki@nms.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Aoyama
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohara
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Futami-Suda
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Motoshi
authors.initials: M
authors.lastname: Ouchi
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Igari
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000273:Adipose Tissue; D001647:Bile Acids and Salts / Q000378:metabolism*; D001835:Body Weight; D064368:Healthy Volunteers; D006801:Humans; D019518:Postprandial Period
chemical_list: D001647:Bile Acids and Salts
keywords: Bile acid; Body compositions; Body fat mass; Conjugation; Normal weight