title: Bioactive marine drugs and marine biomaterials for brain diseases.
abstract: Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development. This review aims to summarize the potential of drugs derived from marine invertebrates in the field of neuroscience. Therefore, some examples of neuroprotective drugs and neurotoxins will be discussed. Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration. In addition, the neuronal growth promoted by marine drugs, as well as the recent advances in neural tissue engineering, will be highlighted.
authors.affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. acfmtgrosso@ff.up.pt.
authors.forename: Clara
authors.initials: C
authors.lastname: Grosso
authors.affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. valentao@ff.up.pt.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Valentão
authors.affiliation: Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, Campus University Espinardo, Murcia 30100, Spain. federico@cebas.csic.es.
authors.forename: Federico
authors.initials: F
authors.lastname: Ferreres
authors.affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal. pandrade@ff.up.pt.
authors.forename: Paula B
authors.initials: PB
authors.lastname: Andrade
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D001927:Brain Diseases / Q000188:drug therapy*; D002240:Carbohydrate Sequence; D006801:Humans; D007448:Invertebrates / Q000737:chemistry; D008969:Molecular Sequence Data; D009416:Nerve Regeneration / Q000187:drug effects; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D009488:Neurosciences / Q000639:trends; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D001688:Biological Products