title: Quasi-static image-based immersed boundary-finite element model of left ventricle under diastolic loading.
abstract: Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure-based hyperelastic strain-energy function to describe the passive mechanics of the ventricular myocardium, a realistic anatomical geometry reconstructed from clinical magnetic resonance images of a healthy human heart, and a rule-based fiber architecture. Numerical predictions of this IB/FE model are compared with results obtained by a commercial FE solver. We demonstrate that the IB/FE model yields results that are in good agreement with those of the conventional FE model under diastolic loading conditions, and the predictions of the LV model using either numerical method are shown to be consistent with previous computational and experimental data. These results are among the first to analyze the stress and strain predictions of IB models of ventricular mechanics, and they serve both to verify the IB/FE simulation framework and to validate the IB/FE model. Moreover, this work represents an important step toward using such models for fully dynamic fluid-structure interaction simulations of the heart. © 2014 The Authors. International Journal for Numerical Methods in Engineering published by John Wiley & Sons, Ltd.
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Huiming
authors.initials: H
authors.lastname: Wang
authors.forename: Colin
authors.initials: C
authors.lastname: Berry
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Luo
authors.forename: Boyce E
authors.initials: BE
authors.lastname: Griffith
mesh_terms: D000465:Algorithms; D001794:Blood Pressure; D020342:Finite Element Analysis; D006331:Heart Diseases / Q000503:physiopathology; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000503:physiopathology*; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular
keywords: finite element method; hyperelasticity; immersed boundary method; left ventricle; structure-based constitutive model; ventricular mechanics