title: Squamous Cell Carcinoma of the Caruncle.
abstract: Squamous cell carcinoma (SCC) of the lacrimal caruncle is a rare entity. The authors report the management and outcomes of 3 cases of caruncle SCC. Case 1 underwent wide margin surgical excision with adjuvant topical chemotherapy for a poorly differentiated SCC. He later developed regional lymph node metastasis and required modified radical neck dissection. Case 2 underwent wide margin surgical excision with cryotherapy and adjuvant topical chemotherapy for an invasive moderately differentiated SCC. She later developed a recurrence and underwent orbital exenteration. Case 3 was a moderately differentiated SCC treated with wide margin excision alone and had no recurrence during 5-year follow up. Careful surveillance of caruncle SCC is required, given the observed propensity for local recurrence and/or regional metastasis.
authors.affiliation: *Corneo Plastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, United Kingdom; †Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.; and ‡North Shore Medical Centre; and §Ophthalmology Department, St Vincent's General Hospital, Sydney, New South Wales, Australia.
authors.forename: Suresh
authors.initials: S
authors.lastname: Sagili
authors.forename: Vivian
authors.initials: V
authors.lastname: Yin
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
authors.forename: Brett
authors.initials: B
authors.lastname: O'Donnell
authors.forename: Robert
authors.initials: R
authors.lastname: Eckstein
authors.forename: Raman
authors.initials: R
authors.lastname: Malhotra
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000601:surgery; D003230:Conjunctival Neoplasms / Q000556:secondary* / Q000628:therapy; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D013508:Ophthalmologic Surgical Procedures; D013365:Submandibular Gland Neoplasms / Q000556:secondary* / Q000628:therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil