title: Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
abstract: Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.
authors.affiliation: Australian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia.
authors.forename: Seong Beom
authors.initials: SB
authors.lastname: Ahn
authors.affiliation: Australian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia.
authors.forename: Abidali
authors.initials: A
authors.lastname: Mohamedali
authors.affiliation: Department of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Charles
authors.initials: C
authors.lastname: Chan
authors.affiliation: Department of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Julie
authors.initials: J
authors.lastname: Fletcher
authors.affiliation: Department of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kwun
authors.affiliation: Department of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Candice
authors.initials: C
authors.lastname: Clarke
authors.affiliation: Department of Colorectal Surgery, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Owen F
authors.initials: OF
authors.lastname: Dent
authors.affiliation: Department of Colorectal Surgery, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Pierre H
authors.initials: PH
authors.lastname: Chapuis
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
authors.forename: Edouard
authors.initials: E
authors.lastname: Nice
authors.affiliation: Australian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Baker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016019:Survival Analysis
chemical_list: D000951:Antigens, Neoplasm; D016023:Integrins; C073878:integrin alphavbeta6