title: Drawtex: breaking the vicious circle of cellular and molecular imbalances.
abstract: Uncontrolled cellular and molecular activity in the inflammatory phase of healing will determine whether a wound becomes chronic. Assessment and interventions designed to remove the barriers to healing are essential in order to break the vicious cycle and to kick-start healing in chronic wounds. This product focus gives an overview of the inflammatory phase of the wound healing continuum; discusses how the imbalance of matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases occurs; how this imbalance manifests itself clinically within the wound; and what health professionals can do in order to tip the balance in favour of healing. It discusses a new wound dressing, Drawtex, which combines three modes of action to maintain a moist wound environment in order to debride, manage exudate and reduce bioburden by locking harmful proteases into its core. Case studies are presented where Drawtex has been used to achieve healing in wounds that were not responding to treatment.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Brown
authors.forename: Mandy
authors.initials: M
authors.lastname: Yorke
mesh_terms: D000368:Aged; D001458:Bandages / Q000592:standards*; D018441:Biofilms; D003646:Debridement; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000451:nursing* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017592:Skin Care / Q000295:instrumentation* / Q000451:nursing*; D014945:Wound Healing