title: The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics.
abstract: The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated in a variety of cancers. As such, it is only fair to conclude that therapies targeting the Wnt pathway may play an essential role in the future of anticancer therapeutics, both alone or in conjunction with traditional therapies.
authors.affiliation: Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, 74200 Karachi, Pakistan.
authors.forename: Asfandyar
authors.initials: A
authors.lastname: Sheikh
authors.affiliation: Shifa College of Medicine, H-8/4 Islamabad, Islamabad, Pakistan.
authors.forename: Asfandyar Khan
authors.initials: AK
authors.lastname: Niazi
authors.affiliation: Jinnah Medical and Dental College, Karachi, Pakistan.
authors.forename: Muhammad Zafar
authors.initials: MZ
authors.lastname: Ahmed
authors.affiliation: Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, 74200 Karachi, Pakistan.
authors.forename: Bushra
authors.initials: B
authors.lastname: Iqbal
authors.affiliation: Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, 74200 Karachi, Pakistan.
authors.forename: Syed Muhammad Saad
authors.initials: SM
authors.lastname: Anwer
authors.affiliation: Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, 74200 Karachi, Pakistan.
authors.forename: Hira Hussain
authors.initials: HH
authors.lastname: Khan