title: Persistent organic pollutants (POPs) and fibroids: results from the ENDO study.
abstract: To evaluate the association between persistent organic pollutants (POPs) and uterine fibroids, we used previously collected data from a cohort of women aged 18-44 years undergoing laparoscopy or laparotomy at 14 participating hospital surgical centers (n=473). POP concentrations were measured in omental fat and serum. Presence of fibroids was defined on the basis of a postoperative diagnosis (n=99). Odds ratios (OR) and 95% confidence interval (CI) for each POP by biologic medium were estimated using unconditional logistic regression adjusted for identified covariates. Concentrations were higher in omental fat than in serum for all POPs. Serum p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was the only POP associated with fibroids (per 1-SD increase in log-transformed p,p'-DDE OR (95% CI): 1.37 (1.05-1.80)). In analyses excluding women diagnosed with endometriosis, a number of polychlorinated biphenyls (PCBs) measured in omental fat were associated with fibroids (PCB 99: 1.64 (1.08, 2.49); PCB 138: 1.64 (1.03, 2.59); PCB 146: 1.54 (1.01, 2.37); PCB 153: 1.88 (1.12, 3.13); PCB 196: 1.60 (1.02, 2.51); PCB 206: 1.52 (1.01, 2.29)). Although exploratory, our study suggests that PCBs may be associated with fibroids in the absence of other gynecologic disorders such as endometriosis, but the associations varied by biologic media with more POPs emerging when quantified in fat.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
authors.forename: Britton
authors.initials: B
authors.lastname: Trabert
authors.affiliation: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health and the Department of Environmental Health Sciences, University at Albany, State University of New York, Albany, New York, USA.
authors.forename: Kurunthachalam
authors.initials: K
authors.lastname: Kannan
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: C Matthew
authors.initials: CM
authors.lastname: Peterson
authors.affiliation: Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, Virginia, USA.
authors.forename: Anna Z
authors.initials: AZ
authors.lastname: Pollack
authors.affiliation: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.
authors.forename: Liping
authors.initials: L
authors.lastname: Sun
authors.affiliation: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.
authors.forename: Germaine M
authors.initials: GM
authors.lastname: Buck Louis
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis / Q000633:toxicity; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000633:toxicity*; D050152:Intra-Abdominal Fat / Q000737:chemistry; D007889:Leiomyoma / Q000139:chemically induced*; D016015:Logistic Models; D016017:Odds Ratio; D009852:Omentum / Q000737:chemistry; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D003633:Dichlorodiphenyl Dichloroethylene