title: Impact of machine perfusion preservation of liver grafts from donation after cardiac death.
abstract: Because of the critical shortage of deceased donor grafts, using a donation after cardiac death (DCD) donor is an important resource. However, the ischemic damage of those DCD grafts jeopardizes organ viability during cold storage. Maintaining organ viability after donation until transplantation is important for optimal graft function and survival. This review describes the effective preservation in transplantation for DCD livers. Concepts and development of machine perfusion for DCD liver grafts to reduce ischemia/reperfusion injury are discussed. Despite the fact that hypothermic machine perfusion might be superior to static cold preservation, DCD livers are exposed to hypothermia-induced damage. Recently, some groups introduced the beneficial effects of normothermic or subnormothermic machine perfusion in DCD liver preservation and transplantation.
authors.affiliation: Department of Innovative Surgery and Transplantation, National Research Institute, National Center for Child Health and Development, Tokyo, Japan; Mechanical Engineering, Tokyo Metropolitan University, Tokyo, Japan; Department of Surgery, Asahikawa Medical University, Hokkaido, Japan. Electronic address: mtnnot@yahoo.co.jp.
authors.forename: N
authors.initials: N
authors.lastname: Matsuno
authors.affiliation: Department of Surgery, Asahikawa Medical University, Hokkaido, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.affiliation: Department of Surgery, Asahikawa Medical University, Hokkaido, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D050377:Cold Ischemia; D046148:Donor Selection; D004867:Equipment Design; D006331:Heart Diseases / Q000401:mortality*; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D009926:Organ Preservation / Q000295:instrumentation / Q000379:methods*; D010477:Perfusion / Q000295:instrumentation / Q000379:methods*; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D017694:Rewarming; D014019:Tissue Donors / Q000600:supply & distribution*; D014022:Tissue Survival; D020858:Tissue and Organ Harvesting; D016896:Treatment Outcome; D052096:Warm Ischemia