title: A case of immunogammaglobulin 4-related disease.
abstract: An 81-year-old woman with history of thyroiditis and a putative diagnosis of retroperitoneal fibrosis presented with abdominal pain, progressive shoulder pain, back pain, and lower extremity weakness. Abdominal and pelvic MRI revealed periaortic inflammation and a left renal mass, which were F-FDG avid on PET/CT. Renal biopsy was compatible with immunogammaglobulin 4 (IgG4)-related disease. Total spine MRI revealed postcontrast meningeal enhancement, correlating with FDG activity. Epidural biopsy showed chronic inflammation and scattered but not abnormal IgG4-positive cells, possibly related to posttreatment changes. This case exemplifies multiorgan involvement in IgG4-related disease.
authors.affiliation: From the *Department of Radiology, Columbia University; and †Department of Internal Medicine, Columbia University and New York Presbyterian Hospital, New York, NY.
authors.forename: Vesselin Z
authors.initials: VZ
authors.lastname: Miloushev
authors.forename: Manuel R
authors.initials: MR
authors.lastname: Cabrera
authors.forename: Masanori
authors.initials: M
authors.lastname: Ichise
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000000981:diagnostic imaging*; D007074:Immunoglobulin G / Q000276:immunology*; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D013131:Spine / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D007074:Immunoglobulin G