title: Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury.
abstract: Ischemia, lack of blood flow, and reperfusion, return of blood flow, are a common phenomenon affecting millions of Americans each year. Roughly 30,000 Americans per year experience intestinal ischemia-reperfusion (IR), which is associated with a high mortality rate. Previous studies of the intestine established a role for neutrophils, eicosanoids, the complement system and naturally occurring antibodies in IR-induced pathology. Furthermore, data indicate involvement of a lipid or lipid-like moiety in mediating IR-induced damage. It has been proposed that antibodies recognize exposure of neo-antigens, triggering action of the complement cascade. While it is evident that the pathophysiology of IR-induced injury is complex and multi-factorial, we focus this review on the involvement of eicosanoids, phospholipids and neo-antigens in the early pathogenesis. Lipid changes occurring in response to IR, neo-antigens exposed and the role of a phospholipid transporter, phospholipid scramblase 1 will be discussed.
authors.affiliation: College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. Electronic address: eslone@ksu.edu.
authors.forename: Emily Archer
authors.initials: EA
authors.lastname: Slone
authors.affiliation: Division of Biology, Kansas State University, Manhattan, KS 66506, USA. Electronic address: sdflemin@ksu.edu.
authors.forename: Sherry D
authors.initials: SD
authors.lastname: Fleming
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000941:Antigens / Q000276:immunology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D008563:Membrane Lipids / Q000378:metabolism*; D049294:Phospholipid Transfer Proteins / Q000378:metabolism; D015427:Reperfusion Injury / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000906:Antibodies; D000941:Antigens; D008563:Membrane Lipids; D049294:Phospholipid Transfer Proteins
keywords: Ischemia;; Lipids;; Neo-antigen; Reperfusion;