title: Translating glycolytic metabolism to innate immunity in dendritic cells.
abstract: Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.
authors.affiliation: Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Cortese
authors.affiliation: Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Sinclair
authors.affiliation: Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA.
authors.forename: Bali
authors.initials: B
authors.lastname: Pulendran
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D006019:Glycolysis; D051550:I-kappa B Kinase / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase