title: Analysis of pericardial effusion from idiopathic pericarditis patients by two-dimensional gel electrophoresis.
abstract: Pericardial fluid (PF) is often considered to be reflection of the serum by which information regarding the physiological status of the heart can be obtained. Some local and systemic disorders may perturb the balance between synthesis and discharge of PF and may cause its aberrant accumulation in the pericardial cavity as pericardial effusion (PE). PE may then lead to an increased intrapericardial pressure from which the heart function is undesirably affected. For some cases, the causes for the perturbance of fluid balance are well understood, but in some other cases, they are not apparent. It may, thus, be helpful to understand the molecular mechanisms behind this troublesome condition to elucidate a clinical approach for therapeutic uses. In this study, protein profiles of PEs from idiopathic pericarditis patients were analyzed. Control samples from patients undergoing elective cardiac surgery (ECS) were included for comparison. In addition to high abundant serum-originated proteins that may not hold significance for understanding the molecular mechanisms behind this disease, omentin-1 was identified and its level was higher for more than two-fold in PE of IP patients. Increased levels of omentin-1 in PE may open a way for understanding the molecular mechanisms behind idiopathic pericarditis (IP).
authors.affiliation: Department of Cardiovascular Surgery, Kocaeli University Medical School, Kocaeli, Turkey.
authors.forename: Sadan
authors.initials: S
authors.lastname: Yavuz
authors.affiliation: Department of Medical Biology, DEKART Proteomics Laboratory, Kocaeli University Medical School, Umuttepe, 41380 Kocaeli, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kasap
authors.affiliation: DEKART Proteomics Laboratory, Kocaeli University Medical School, Kocaeli, Turkey.
authors.forename: Gurler
authors.initials: G
authors.lastname: Akpinar
authors.affiliation: Department of Cardiovascular Surgery, Kocaeli University Medical School, Kocaeli, Turkey.
authors.forename: Ersan
authors.initials: E
authors.lastname: Ozbudak
authors.affiliation: Department of Cardiology, Kocaeli University Medical School, Kocaeli, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Ural
authors.affiliation: Department of Cardiovascular Surgery, Kocaeli University Medical School, Kocaeli, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Berki
mesh_terms: D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000096:biosynthesis / Q000235:genetics / Q000302:isolation & purification*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D005786:Gene Expression Regulation; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000235:genetics* / Q000473:pathology; D010493:Pericarditis / Q000235:genetics* / Q000473:pathology
chemical_list: D001798:Blood Proteins