title: Epigenetic mechanisms underlie resistance to NOTCH inhibition in T-ALL.
abstract: T-ALL cells can become resistant to γ-secretase inhibitors through reversible epigenetic alterations.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001381:Azepines / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm; D044127:Epigenesis, Genetic / Q000187:drug effects*; D006801:Humans; D009842:Oligopeptides / Q000008:administration & dosage; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D051881:Receptor, Notch1 / Q000235:genetics; D014230:Triazoles / Q000008:administration & dosage
chemical_list: C561695:(+)-JQ1 compound; D000970:Antineoplastic Agents; D001381:Azepines; C497761:NOTCH1 protein, human; D009842:Oligopeptides; D051881:Receptor, Notch1; D014230:Triazoles; C523462:benzyloxycarbonyl-leucyl-leucyl-norleucinal