title: [RAGE, NF-kappaB, p21 expressions in mouse spiral ganglion cells].
abstract: OBJECTIVE
  To research advanced glycation end-product receptors (RAGE), NF-kappaB, p21 expressions in C57BL/6j mice cochlea spiral ganglion cells(SGC) ,and then to investigate the presbycusis pathogenesis.
  
  
  METHODS
  To take C57BL/6J mice:2 month 25,and 10 month 25. Histological sections were observed the SGC. RAGE, NF-kappaB, p21 were immunohistochemical in the SGC,with IPP6 to IOD.
  
  
  RESULTS
  (1) The count SGCs of 10 month-old was obviously decreased comparing to 2 month-old, the count of 2 month SGC is 39 +/- 5, 10 month group is 20 +/- 6, P < 0.01; (2) RAGE, NF-kappaB, p21 expressed in spiral ganglion cell,different place with different age,and the means optical density in the 10 month are higher than the 2 month, respectively. The IOD of RAGE expression in 2 month SGC: 0.179 +/- 0.025, 10 month IOD: 0.308 +/- 0.050; The IOD of NF-kappaB expression in 2 month SGC: 0.181 +/- 0.045, 10 month IOD: 0.335 +/- 0.120; The IOD of p21 expression in 2 month SGC: 0.160 +/- 0.023, 10 month IOD: 0.365 +/- 0.031, compare with 2 group, respectively, P < 0.05, and the difference has statistics sense.
  
  
  CONCLUSIONS
  RAGE,NF-kappaB, p21 expressions are in SGCs and increases with the aging of SGCs, suppose RAGE, NF-kappaB, p21 may participate in the process of presbycusis pathogenesis.
authors.forename: Xianting
authors.initials: X
authors.lastname: Gao
authors.forename: Chang
authors.initials: C
authors.lastname: Lin
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Gengtian
authors.initials: G
authors.lastname: Liang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Chen
authors.forename: Xujing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000375:Aging; D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D011304:Presbycusis / Q000473:pathology; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D013136:Spiral Ganglion / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D016283:Proto-Oncogene Proteins p21(ras)