title: Yeast oropharyngeal colonization in human immunodeficiency virus-infected patients in central taiwan.
abstract: A prospective, cross-sectional study was conducted at a medical center in central Taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. Oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. Of the 154 isolates, Candida albicans was the most common species (114, 74 %), followed by Candida dubliniensis (10, 6.5 %), Candida glabrata (10, 6.5 %), Candida tropicalis (7, 4.5 %), and 13 others. We found that receiving antituberculous drug (p = 0.046) or atazanavir (p = 0.045) was two predictors for patients colonized by non-C. albicans species (p = 0.005) and risking mixed yeast colonization (p = 0.009). Even though our data showed that clinical antifungal drugs remained effective in vitro against the colonizing yeasts, the increased mixed yeast colonization indicates a potential issue for controlling mixed infections in hospital settings.
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Mao-Wang
authors.initials: MW
authors.lastname: Ho
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Yang
authors.forename: Chih-Chao
authors.initials: CC
authors.lastname: Lin
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Chi
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Chen
authors.forename: Po-Chang
authors.initials: PC
authors.lastname: Lin
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Hsieh
authors.forename: Chia-Hui
authors.initials: CH
authors.lastname: Chou
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Chu
authors.forename: Chiou-Pyng
authors.initials: CP
authors.lastname: Wu
authors.forename: Tsai-Ling
authors.initials: TL
authors.lastname: Lauderdale
authors.forename: Hsiu-Jung
authors.initials: HJ
authors.lastname: Lo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D003430:Cross-Sectional Studies; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009960:Oropharynx / Q000382:microbiology*; D011446:Prospective Studies; D013624:Taiwan
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole