title: Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.
abstract: Pharmacochemistry and integrated pharmacokinetics of six alkaloids (groenlandicine, berberine, palmatine, epiberberine, jatrorrhizine, and columbamine) after oral administration of Huang-Lian-Jie-Du-Tang (HLJDT) decoction were investigated in this paper. The method of plasma pharmacochemistry was applied to predict the potential bioactive components in HLJDT decoction. Based on the accurate molecular weight, 10 components including 2 flavonoids (baicalin and wogonoside), 1 iridoid glycoside (geniposide), and 7 alkaloids (above-mentioned 6 alkaloids and coptisine) were structurally identified. Then, integrated pharmacokinetics of the alkaloids in Sprague-Dawley rats after oral administration of HLJDT decoction was investigated by HPLC method. The results showed that the pharmacokinetic behaviors of the alkaloids were different although their chemical structures were similar. This study developed a method to predict the potential bioactive components in HLJDT decoction and research the pharmacokinetic behaviors of the potential bioactive components.
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs (Peking University), Department of Natural Medicines , School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University , Beijing 100191 , China.
authors.forename: Zhao-Tang
authors.initials: ZT
authors.lastname: Ma
authors.forename: Xiu-Wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids / Q000493:pharmacokinetics*; D000818:Animals; D001599:Berberine / Q000008:administration & dosage / Q000031:analogs & derivatives; D001600:Berberine Alkaloids / Q000008:administration & dosage; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044950:Flavanones / Q000008:administration & dosage; D005419:Flavonoids / Q000008:administration & dosage; D005960:Glucosides / Q000008:administration & dosage; D039823:Iridoids / Q000008:administration & dosage; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000470:Alkaloids; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; D005960:Glucosides; D039823:Iridoids; C045607:huang-lien-chieh-tu-tang; C061676:oren gedoku to; C055785:jatrorrhizine; C034384:coptisine; D001599:Berberine; C007835:geniposide; C038044:baicalin; C061432:epiberberine; C055786:columbamine; C473995:wogonoside; C005413:palmatine
keywords: Huang-Lian-Jie-Du-Tang decoction; Coptis chinensis; Scutellaria baicalensis; alkaloid; flavonoid; pharmacokinetics