title: The changing role of the pathologist in the management of Barrett's oesophagus.
abstract: Pathological specimens from columnar-lined oesophagus (CLO) comprise a considerable proportion of the workload of gastrointestinal pathologists in Western countries. There remain controversies concerning the diagnostic role of pathology. More recently, in the UK at least, the diagnosis has been regarded as primarily an endoscopic endeavour, with pathology being corroborative and only diagnostic when endoscopic features are equivocal or when there are additional features that make the endoscopic diagnosis unclear. There is also recognition that demonstration of intestinalisation or 'goblet cells' is not paramount, and should not be required for the diagnosis. There have been notable changes in the management of CLO neoplasia: pathologists are centrally involved in its management. Pathological assessment of endoscopic mucosal resection (EMR) specimens provides the most useful means of determining the management of early neoplasia and of determining indications for surgery. This represents an extraordinarily rapid change in management, in that, <10 years ago, laborious Seattle-type biopsy protocols were recommended, and high grade dysplasia was an indication for resectional surgery. Now, individual patient management is paramount: multi-professional meetings determine management after biopsy and EMR assessment. One significant change is that major resections are undertaken less often, in Western countries, for CLO neoplasia.
authors.affiliation: Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital, Cheltenham, UK.
authors.forename: Suzanne A
authors.initials: SA
authors.lastname: Hopcroft
authors.forename: Neil A
authors.initials: NA
authors.lastname: Shepherd
mesh_terms: D055011:Ablation Techniques; D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology*; D000423:Alcian Blue; D001471:Barrett Esophagus / Q000145:classification / Q000473:pathology* / Q000601:surgery; D001706:Biopsy; D004847:Epithelial Cells / Q000473:pathology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology*; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology*; D020397:Goblet Cells / Q000473:pathology; D006551:Hernia, Hiatal / Q000473:pathology; D006801:Humans; D008679:Metaplasia / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D011230:Precancerous Conditions / Q000473:pathology*
chemical_list: D000423:Alcian Blue
keywords: Barrett's oesophagus; adenocarcinoma; definition; diagnosis; dysplasia; management; neoplasia; oesophagus