title: A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG.
abstract: OBJECTIVE
  To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma (POAG) and the addition of other intraocular pressure (IOP) lowering medications such as prostaglandin analogs and brimonidine.
  
  
  METHODS
  A retrospective, non-randomized, and descriptive clinical study was performed with 182 eyes diagnosed with POAG. Patients were divided into three groups: a group with fixed combination of dorzolamide/timolol only, a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol, and a third group with the addition of brimonidine to the same fixed combination. IOP data were gathered retrospectively and the differences between groups were calculated.
  
  
  RESULTS
  IOP was reduced satisfactorily in all three groups; however, a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin analogs. In this group, a progressive, significant and more homogeneous response of the reduction was noted in comparison with the other groups.
  
  
  CONCLUSIONS
  IOP reduction was efficacious in all three groups. The addition of prostaglandin analogs showed progressive IOP reduction, progressive response and absence of long-term drift. Brimonidine did not show a significant additive effect.
authors.affiliation: Glaucoma Service, Instituto de Oftalmología Fundación Conde de Valenciana, Mexico City 06800, Mexico.
authors.forename: Curt
authors.initials: C
authors.lastname: Hartleben-Matkin
authors.affiliation: Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología de México, México City 14080, Mexico ; Departamento de Informática Biomédica, Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM), México City 04510, México ; Laboratory of Environmental Epigenetics, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Diddier
authors.initials: D
authors.lastname: Prada
authors.affiliation: Glaucoma Service, Instituto de Oftalmología Fundación Conde de Valenciana, Mexico City 06800, Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Mancilla-Vences
keywords: Cosopt®; brimonidine; dorzolamide/timolol; fixed combination; glaucoma; prostaglandin analogs