title: Association between alcohol intake, overweight, and serum lipid levels and the risk analysis associated with the development of dyslipidemia.
abstract: BACKGROUND
  Alcohol, overweight, and lipid metabolism contribute to fatty liver and atherosclerosis pathogenesis.
  
  
  OBJECTIVE
  To study the association of alcoholic intake, overweight, and dyslipidemia.
  
  
  METHODS
  We randomly selected 482 age- and sex-matched individuals from East China. Gender, age, education level, smoking, hypertension, daily alcohol intake, drinking duration, and body mass index (BMI) were evaluated in association with triglyceride, total cholesterol, high-density (HDL-C), and low-density lipoprotein-cholesterol.
  
  
  RESULTS
  The association between dyslipidemia and 8 predictors of disease was made by regression analysis through the generalized additive model. The results showed that age, daily alcohol intake, and BMI were all closely associated with hypertriglyceridemia. Age, duration of drinking, and BMI were all closely associated with hypercholesterolemia. Age and BMI status were both closely associated with high LDL-C levels. By contrast, none of the 8 predictors was closely associated with low HDL-C levels (all P < .05).
  
  
  CONCLUSIONS
  Daily alcohol intake was a risk factor for hypertriglyceridemia. By contrast, drinking duration was a protective factor against hypercholesterolemia. Age and BMI were important risk factors for dyslipidemia (excluding HDL-C).
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Shen
authors.affiliation: Molecular Hepatology-Alcohol Associated Diseases, II. Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Munker
authors.affiliation: Institute of Biostatistics, School of Life Sciences, Fudan University, 200433 Shanghai, China.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Hongtan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Genyun
authors.initials: G
authors.lastname: Xu
authors.affiliation: Institute of Biostatistics, School of Life Sciences, Fudan University, 200433 Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
authors.forename: Chaohui
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China. Electronic address: zjulym@126.com.
authors.forename: Youming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology*; D015992:Body Mass Index; D002681:China; D050171:Dyslipidemias / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D008077:Lipoproteins, LDL
keywords: Alcohol; High-density lipoprotein cholesterol; Low-density lipoprotein cholesterol; Overweight; Total cholesterol; Triglycerides