title: Prevalence of lipodystrophy and risk factors for dyslipidemia in HIV-infected children in Brazil.
abstract: The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol >200mg/dl or triglycerides >130mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated with dyslipidemia were: low intake of vegetables/fruits (OR=3.47, 95%CI=1.04-11.55), current use of lopinavir/ritonavir (OR=2.91, 95%CI=1.11-7.67). In conclusion, LSHIV was frequently observed; inadequate dietary intake of sugars and fats, as well as current use of lopinavir/ritonavir was associated with dyslipidemia.
authors.affiliation: Preventive Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Luanda
authors.initials: L
authors.lastname: Papi
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Carolina G B
authors.initials: AC
authors.lastname: Menezes
authors.affiliation: Department of Pediatrics, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Hélio
authors.initials: H
authors.lastname: Rocha
authors.affiliation: Department of Pediatrics, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Thalita F
authors.initials: TF
authors.lastname: Abreu
authors.affiliation: Department of Pediatrics, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Ricardo Hugo de
authors.initials: RH
authors.lastname: Oliveira
authors.affiliation: Department of Pediatrics, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Cristina C
authors.initials: AC
authors.lastname: Frota
authors.affiliation: Department of Pediatrics, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Lucia de A
authors.initials: Lde A
authors.lastname: Evangelista
authors.affiliation: Preventive Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address: cbhofer@hucff.ufrj.br.
authors.forename: Cristina B
authors.initials: CB
authors.lastname: Hofer
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008297:Male; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D019380:Anti-HIV Agents
keywords: Children; Dyslipidemia; HIV; Lipodystrophy