title: Cleveland Clinic's Center for personalized healthcare: setting the stage for value-based care.
abstract: Cleveland Clinic (OH, USA) launched the Center for Personalized Healthcare in 2011 to establish an evidence-based system for individualizing care by incorporating unique patient characteristics, including but not limited to genetic and family health history information, into the standard medical decision-making process. Using MyFamily, a web-based tool integrated into our electronic health record, a patient's family health history is used as a surrogate for genetic, environmental and behavioral risks to identify those with an elevated probability of developing disease. Complementing MyFamily, the Personalized Medication Program was created for the purpose of identifying gene-drug pairs for integration into clinical practice and developing the implementation tools needed to incorporate pharmacogenomics into the clinical workflow. We have successfully implemented the gene-drug pairs HLA-B*57:01-abacavir and TPMT-thiopurines into patient care. Our efforts to establish personalized medical care at Cleveland Clinic may serve as a model for large-scale integration of personalized healthcare.
authors.affiliation: Center for Personalized Healthcare, Internal Medicine, Cleveland Clinic, 9500 Euclid Ave, NE50, Cleveland, OH 44195, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Teng
authors.forename: Jennifer
authors.initials: J
authors.lastname: DiPiero
authors.forename: Thad
authors.initials: T
authors.lastname: Meese
authors.forename: Megan
authors.initials: M
authors.lastname: Doerr
authors.forename: Mandy
authors.initials: M
authors.lastname: Leonard
authors.forename: Thomas
authors.initials: T
authors.lastname: Daly
authors.forename: Felicitas
authors.initials: F
authors.lastname: Lacbawan
authors.forename: Jeff
authors.initials: J
authors.lastname: Chalmers
authors.forename: David
authors.initials: D
authors.lastname: Stowe
authors.forename: Scott
authors.initials: S
authors.lastname: Knoer
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Hicks
mesh_terms: D019317:Evidence-Based Medicine; D006040:Goals; D006801:Humans; D010597:Pharmacogenetics / Q000191:economics / Q000193:education / Q000639:trends; D057285:Precision Medicine / Q000191:economics* / Q000639:trends*; D018570:Risk Assessment