title: ADSC therapy in neurodegenerative disorders.
abstract: Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases. However, these diseases all have the common characteristic that they are due to degenerative irreversibility, and thus no efficient drugs or therapy methods can mitigate symptoms completely. Stem cell therapy, such as adipose tissue-derived stem cells (ADSCs), is a promising treatment for incurable disorders. In this review, we summarized the previous studies using ADSCs to treat neurodegenerative disorders, as well as their therapeutic mechanisms. We also suggested possible expectations for future human clinical trials involving minimized intracerebroventricular combined with intravenous administration, using different cell lineages to finish complementary therapy as well as change the extracellular matrix to create a homing niche. Depending on successful experiments in relevant neurodegenerative disorders models, this could form the theoretical basis for future human clinical trials.
authors.affiliation: Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Tzu-Min
authors.initials: TM
authors.lastname: Chan
authors.forename: Julia Yi-Ru
authors.initials: JY
authors.lastname: Chen
authors.forename: Li-Ing
authors.initials: LI
authors.lastname: Ho
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Lin
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Hsueh
authors.forename: Demeral David
authors.initials: DD
authors.lastname: Liu
authors.forename: Yi-Hung
authors.initials: YH
authors.lastname: Chen
authors.forename: An-Cheng
authors.initials: AC
authors.lastname: Hsieh
authors.forename: Nu-Man
authors.initials: NM
authors.lastname: Tsai
authors.forename: Dueng-Yuan
authors.initials: DY
authors.lastname: Hueng
authors.forename: Sheng-Tzeng
authors.initials: ST
authors.lastname: Tsai
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Chou
authors.forename: Shinn-Zong
authors.initials: SZ
authors.lastname: Lin
authors.forename: Horng-Jyh
authors.initials: HJ
authors.lastname: Harn
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000544:Alzheimer Disease / Q000628:therapy; D000690:Amyotrophic Lateral Sclerosis / Q000628:therapy; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D006816:Huntington Disease / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000628:therapy*; D010300:Parkinson Disease / Q000628:therapy; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*