title: Oligo(phenylene ethynylene) glucosides: modulation of cellular uptake capacity preserving light ON.
abstract: A new family of oligo(phenylene ethynylene) (OPE) glucosides has been prepared and characterized. Our results demonstrate that fine-tuning of their photophysical properties can be obtained by acting on the electronics of the core and molecular skeleton. Modulation of the hydrophobic chain length and substituents on the central moieties influences the bioaffinity too. In particular, introducing a NMe2 group on the aromatic central core affords a highly efficient biocompatible fluorescent probe that can be taken up in cytoplasmic vesicles of HEp-2 cells (cells from epidermoid carcinoma larynx tissue). The photophysical behavior, high quantum yield, and stability open the way to the use of the OPE family as stains for cellular imaging analysis by fluorescence microscopy.
authors.affiliation: Dipartimento di Scienze Chimiche and SolarChem-Centro di Ricerca Interuniversitario per la Conversione Chimica dell'Energia Solare, Università di Messina , 98166 Messina, Italia.
authors.forename: Anna
authors.initials: A
authors.lastname: Barattucci
authors.forename: Elisa
authors.initials: E
authors.lastname: Deni
authors.forename: Paola
authors.initials: P
authors.lastname: Bonaccorsi
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Ceraolo
authors.forename: Teresa
authors.initials: T
authors.lastname: Papalia
authors.forename: Antonio
authors.initials: A
authors.lastname: Santoro
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Sciortino
authors.forename: Fausto
authors.initials: F
authors.lastname: Puntoriero
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D011789:Quantum Theory
chemical_list: D005456:Fluorescent Dyes; D005960:Glucosides; D011108:Polymers; C473966:poly(phenylene ethynylene)