title: Endogenous RNAi pathways in C. elegans.
abstract: In addition to several hundred microRNAs, C. elegans produces thousands of other small RNAs targeting coding genes, pseudogenes, transposons, and other noncoding RNAs. Here we review what is currently known about these endogenous small interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNAs), providing an overview of their biogenesis, their associated protein factors, and their effects on mRNA dynamics and chromatin structure. Additionally, we describe how the molecular actions of these classes of endogenous small RNAs connect to their physiological roles in the organism.
authors.affiliation: Life Sciences Institute, Department of Human Genetics, University of Michigan, Ann Arbor MI, USA. jnkim@umich.edu.
authors.forename: Allison C
authors.initials: AC
authors.lastname: Billi
authors.forename: Sylvia E J
authors.initials: SE
authors.lastname: Fischer
authors.forename: John K
authors.initials: JK
authors.lastname: Kim
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D018510:RNA, Helminth; D034741:RNA, Small Interfering
chemical_list: D018510:RNA, Helminth; D034741:RNA, Small Interfering