title: The multivalent effect in glycosidase inhibition: a new, rapidly emerging topic in glycoscience.
abstract: A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly emerging area with exciting potential and scope. This review presents a description of the different types of neoglycoclusters and their evaluation as glycosidase inhibitors. The first promising therapeutic applications are discussed, as well as the mechanisms underlying the observed inhibitory multivalent effect.
authors.affiliation: Laboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg/CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087 Strasbourg (France); Institut Universitaire de France, 103 Bd Saint-Michel, 75005 Paris (France). philippe.compain@unistra.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Compain
authors.forename: Anne
authors.initials: A
authors.lastname: Bodlenner
mesh_terms: D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006023:Glycoproteins / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006031:Glycosylation; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D006023:Glycoproteins; D006026:Glycoside Hydrolases
keywords: click chemistry; glycosidases; iminosugars; inhibitors; multivalency