title: [Research on amplitude of low-frequency fluctuation in patients with major depression based on resting-state functional magnetic resonance imaging].
abstract: We investigated the baseline brain activity level in patients with major depressive disorder (MDD) by am plitude of low-frequency fluctuation (ALFF) based on resting-state functional MRI (fMRI). We examined 13 patients in the MDD group and 14 healthy volunteers in the control group by resting-state fMRI on GE Signa 3.0T. We calculated and compared the ALFF values of the two groups. In the MDD group, ALFF values in the right medial prefrontal were higher than those in control group, with statistically significant differences (P < 0.001). ALFF values in the left parietal in the MDD group were lower than those in control group with statistically significant differences (P < 0.001). This resting-state fMRI study suggested that the alteration brain activity in the right medial prefrontal and left parietal ALFF contributed to the understanding of the pathophysiological mechanism of MDD patients.
authors.forename: Haitang
authors.initials: H
authors.lastname: Qiu
authors.forename: Haixia
authors.initials: H
authors.lastname: Liu
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Huaqing
authors.initials: H
authors.lastname: Meng
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Fu
authors.forename: Lian
authors.initials: L
authors.lastname: Du
authors.forename: Tian
authors.initials: T
authors.lastname: Qiu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Luo
mesh_terms: D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging