title: Identification of specific Y chromosomes associated with increased prostate cancer risk.
abstract: BACKGROUND
  Evidence supports the possibility of a role of the Y chromosome in prostate cancer, but controversy exists.
  
  
  METHODS
  A novel analysis of a computerized population-based resource linking genealogy and cancer data was used to test the hypothesis of a role of the Y chromosome in prostate cancer predisposition. Using a statewide cancer registry from 1966 linked to a computerized genealogy representing over 1.2 million descendants of the Utah pioneers, 1,000 independent sets of males, each set hypothesized to share the same Y chromosome as represented in genealogy data, were tested for a significant excess of prostate cancer.
  
  
  RESULTS
  Multiple Y chromosomes representing thousands of potentially at-risk males were identified to have a significant excess risk for prostate cancer.
  
  
  CONCLUSIONS
  This powerful and efficient in silico test of an uncommon mode of inheritance has confirmed evidence for Y chromosome involvement in prostate cancer.
authors.affiliation: Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah; Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Cannon-Albright
authors.forename: James M
authors.initials: JM
authors.lastname: Farnham
authors.forename: Matthew
authors.initials: M
authors.lastname: Bailey
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Albright
authors.forename: Craig C
authors.initials: CC
authors.lastname: Teerlink
authors.forename: Neeraj
authors.initials: N
authors.lastname: Agarwal
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stephenson
authors.forename: Alun
authors.initials: A
authors.lastname: Thomas
mesh_terms: D041322:Chromosomes, Human, Y; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014589:Utah / Q000453:epidemiology
keywords: UPDB; Y chromosome; prostate cancer