title: Fast and early mandibular osteogenetic distraction in a 24-day-old female newborn with Larsen syndrome.
abstract: BACKGROUND
  Larsen syndrome (LS) is a rare bone dysplasia characterized by multiple dislocations affecting large and small joints, progressive scoliosis, accessory and early ossifying carpal/tarsal bones, and characteristic craniofacial features.
  
  
  METHODS
  A newborn with a clinical diagnosis of LS is presented. Shortly after birth, she had respiratory distress due to retrognathia. Such a life-threatening complication was resolved by mandibular distraction osteogenesis at 24 days of age.
  
  
  CONCLUSIONS
  Fast and early mandibular osteogenetic distraction could represent an optimal tool to avoid tracheostomy and to improve oral feeding in patients with rare conditions, such as LS.
authors.affiliation: From the *Dipartimento di Scienze Odontostomatologiche e maxillofacciali, and †Dipartimento di Pediatria, Emergenza Pediatrica e Terapia Intensiva, Università Sapienza di Roma; and ‡Divisione di Genetica Medica, Dipartimento di Medicina Molecolare, Università Sapienza, Ospedale San Camillo-Forlanini l, Roma, Italia.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Basile
authors.forename: Valerio
authors.initials: V
authors.lastname: Ramieri
authors.forename: Paola
authors.initials: P
authors.lastname: Papoff
authors.forename: Marco
authors.initials: M
authors.lastname: Castori
authors.forename: Paola
authors.initials: P
authors.lastname: Grammatico
authors.forename: Cristiana
authors.initials: C
authors.lastname: Bianca
authors.forename: Diletta
authors.initials: D
authors.lastname: Angeletti
authors.forename: Piero
authors.initials: P
authors.lastname: Cascone
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008334:Mandible / Q000601:surgery*; D010009:Osteochondrodysplasias / Q000150:complications / Q000601:surgery; D019857:Osteogenesis, Distraction / Q000379:methods*; D017286:Polysomnography / Q000379:methods; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology / Q000601:surgery; D063173:Retrognathia / Q000209:etiology / Q000601:surgery*