title: Eosinophilic esophagitis: emerging therapies and future perspectives.
abstract: Twenty years have passed since eosinophilic esophagitis was first recognized as a new and distinct entity. Current treatment modalities for eosinophilic esophagitis include the "3 Ds": drugs, allergen avoidance with diet, and esophageal dilation. Drugs entail the limitation that only corticosteroids have a proven efficacy; most other compounds evoke only a minimal effect. Diets must be maintained continuously and they interfere markedly with the quality of life, possibly even involving some risk of malnutrition. A greater understanding of the immunopathogenesis, natural history, and disease spectrum will inevitably lead to improved therapeutic outcomes for this emerging entity.
authors.affiliation: Swiss EoE Clinic and Swiss EoE Research Network, Roemerstrasse 7, Olten 4600, Switzerland. Electronic address: alex.straumann@hin.ch.
authors.forename: Alex
authors.initials: A
authors.lastname: Straumann
mesh_terms: D057765:Eosinophilic Esophagitis / Q000628:therapy*; D005544:Forecasting; D006801:Humans
keywords: CRTH2 antagonists; Disease monitoring; Eosinophilic esophagitis; Esophageal distensibility; Esophageal string test; IL-13 antagonist; IL-4 antagonist