title: Lack of drug dosing guidelines for critically ill patients receiving continuous renal replacement therapy.
abstract: Acute kidney injury requiring continuous renal replacement therapy is common, costly, and associated with mortality rates of up to 60%. Accurate pharmacokinetic data are essential to developing rational individualized dosing strategies and providing optimal care to these patients, yet few such data exist, probably due in part to an absence of regulatory guidance on the issue. The Kidney Health Initiative is working with stakeholders to propose strategies to address this in a standardized manner.
authors.affiliation: Center for Acute Care Nephrology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Goldstein
authors.affiliation: Center for Clinical Pharmaceutical Sciences, Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Nolin
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016638:Critical Illness / Q000453:epidemiology / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards*; D017582:Renal Replacement Therapy / Q000592:standards*; D012955:Societies, Medical / Q000592:standards*; D014481:United States / Q000453:epidemiology; D014486:United States Food and Drug Administration / Q000592:standards*
chemical_list: D000900:Anti-Bacterial Agents