title: Central pain processing in chronic chemotherapy-induced peripheral neuropathy: a functional magnetic resonance imaging study.
abstract: Life expectancy in multiple myeloma has significantly increased. However, a high incidence of chemotherapy induced peripheral neuropathy (CIPN) can negatively influence quality of life during this period. This study applied functional magnetic resonance imaging (fMRI) to compare areas associated with central pain processing in patients with multiple myeloma who had chemotherapy induced peripheral neuropathy (MM-CIPN) with those from healthy volunteers (HV). Twenty-four participants (n = 12 MM-CIPN, n = 12 HV) underwent Blood Oxygen Level-Dependent (BOLD) fMRI at 3T whilst noxious heat-pain stimuli were applied to the foot and then thigh. Patients with MM-CIPN demonstrated greater activation during painful stimulation in the precuneus compared to HV (p = 0.014, FWE-corrected). Patients with MM-CIPN exhibited hypo-activation of the right superior frontal gyrus compared to HV (p = 0.031, FWE-corrected). Significant positive correlation existed between the total neuropathy score (reduced version) and activation in the frontal operculum (close to insular cortex) during foot stimulation in patients with MM-CIPN (p = 0.03, FWE-corrected; adjusted R2 = 0.87). Painful stimuli delivered to MM-CIPN patients evoke differential activation of distinct cortical regions, reflecting a unique pattern of central pain processing compared with healthy volunteers. This characteristic activation pattern associated with pain furthers the understanding of the pathophysiology of painful chemotherapy induced peripheral neuropathy. Functional MRI provides a tool for monitoring cerebral changes during anti-cancer and analgesic treatment.
authors.affiliation: Academic Unit of Radiology, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, United Kingdom; Academic Unit of Supportive Care, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Elaine G
authors.initials: EG
authors.lastname: Boland
authors.affiliation: Department of Diabetes, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Selvarajah
authors.affiliation: Academic Clinical Psychiatry, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Mike
authors.initials: M
authors.lastname: Hunter
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Ezaydi
authors.affiliation: Department of Diabetes, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
authors.forename: Solomon
authors.initials: S
authors.lastname: Tesfaye
authors.affiliation: Academic Unit of Supportive Care, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Sam H
authors.initials: SH
authors.lastname: Ahmedzai
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
authors.forename: John A
authors.initials: JA
authors.lastname: Snowden
authors.affiliation: Academic Unit of Radiology, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Iain D
authors.initials: ID
authors.lastname: Wilkinson
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064926:Neurophysiological Monitoring; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D010812:Physical Stimulation; D011788:Quality of Life; D013696:Temperature