title: The proteomics of drusen.
abstract: The formation of extracellular deposits known as drusen below the macular region of the retina correlates with increased risk of severe visual loss from age-related macular degeneration (AMD). Inflammation and complement dysregulation contribute to AMD progression; however, disease mechanisms remain incompletely defined. Multiple genetic and environmental factors influence AMD pathology, and although immune system processes play a central role, multiple molecular mechanisms appear to be involved. Drusen proteomics, including the analyses of constituent proteins, oxidative protein modifications, and pattern recognition receptors, provide a foundation for deciphering mechanisms of drusen biogenesis and AMD pathology.
authors.affiliation: Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195.
authors.forename: John W
authors.initials: JW
authors.lastname: Crabb
mesh_terms: D000818:Animals; D016570:Bruch Membrane / Q000737:chemistry; D002829:Choroid / Q000737:chemistry; D004195:Disease Models, Animal; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics; D051379:Mice; D018384:Oxidative Stress / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D040901:Proteomics; D015593:Retinal Drusen / Q000235:genetics* / Q000276:immunology
chemical_list: D011506:Proteins