title: Correspondence between neurophysiological and clinical measurements of chemotherapy-induced peripheral neuropathy: secondary analysis of data from the CI-PeriNomS study.
abstract: Chemotherapy-induced peripheral neuropathy (CIPN) lacks standardized clinical measurement. The objective of the current secondary analysis was to examine data from the CIPN Outcomes Standardization (CI-PeriNomS) study for associations between clinical examinations and neurophysiological abnormalities. Logistic regression estimated the strength of associations of vibration, pin, and monofilament examinations with lower limb sensory and motor amplitudes. Examinations were classified as normal (0), moderately abnormal (1), or severely abnormal (2). Among 218 participants, those with class 1 upper extremity (UE) and classes 1 or 2 lower extremity (LE) monofilament abnormality were 2.79 (95% confidence interval [CI]: 1.28-6.07), 3.49 (95%CI: 1.61-7.55), and 4.42 (95%CI: 1.35-14.46) times more likely to have abnormal sural nerve amplitudes, respectively, compared to individuals with normal examinations. Likewise, those with class 2 UE and classes 1 or 2 LE vibration abnormality were 8.65 (95%CI: 1.81-41.42), 2.54 (95%CI: 1.19-5.41), and 7.47 (95%CI: 2.49-22.40) times more likely to have abnormal sural nerve amplitudes, respectively, compared to participants with normal examinations. Abnormalities in vibration and monofilament examinations are associated with abnormal sural nerve amplitudes and are useful in identifying CIPN.
authors.affiliation: Department of Organizational Systems and Adult Health, University of Maryland, Baltimore, MD, USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Griffith
authors.forename: Susan G
authors.initials: SG
authors.lastname: Dorsey
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Renn
authors.forename: Shijun
authors.initials: S
authors.lastname: Zhu
authors.forename: Mary E
authors.initials: ME
authors.lastname: Johantgen
authors.forename: David R
authors.initials: DR
authors.lastname: Cornblath
authors.forename: Andreas A
authors.initials: AA
authors.lastname: Argyriou
authors.forename: Guido
authors.initials: G
authors.lastname: Cavaletti
authors.forename: Ingemar S J
authors.initials: IS
authors.lastname: Merkies
authors.forename: Paola
authors.initials: P
authors.lastname: Alberti
authors.forename: Tjeerd J
authors.initials: TJ
authors.lastname: Postma
authors.forename: Emanuela
authors.initials: E
authors.lastname: Rossi
authors.forename: Barbara
authors.initials: B
authors.lastname: Frigeni
authors.forename: Jordi
authors.initials: J
authors.lastname: Bruna
authors.forename: Roser
authors.initials: R
authors.lastname: Velasco
authors.forename: Haralabos P
authors.initials: HP
authors.lastname: Kalofonos
authors.forename: Dimitri
authors.initials: D
authors.lastname: Psimaras
authors.forename: Damien
authors.initials: D
authors.lastname: Ricard
authors.forename: Andrea
authors.initials: A
authors.lastname: Pace
authors.forename: Edvina
authors.initials: E
authors.lastname: Galie
authors.forename: Chiara
authors.initials: C
authors.lastname: Briani
authors.forename: Chiara
authors.initials: C
authors.lastname: Dalla Torre
authors.forename: Catharina G
authors.initials: CG
authors.lastname: Faber
authors.forename: Roy I
authors.initials: RI
authors.lastname: Lalisang
authors.forename: Willem
authors.initials: W
authors.lastname: Boogerd
authors.forename: Dieta
authors.initials: D
authors.lastname: Brandsma
authors.forename: Susanne
authors.initials: S
authors.lastname: Koeppen
authors.forename: Joerg
authors.initials: J
authors.lastname: Hense
authors.forename: Dawn J
authors.initials: DJ
authors.lastname: Storey
authors.forename: Simon
authors.initials: S
authors.lastname: Kerrigan
authors.forename: Angelo
authors.initials: A
authors.lastname: Schenone
authors.forename: Sabrina
authors.initials: S
authors.lastname: Fabbri
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Valsecchi
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000368:Aged; D066264:Datasets as Topic / Q000706:statistics & numerical data; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000150:complications*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D009460:Neurologic Examination; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D013497:Sural Nerve / Q000503:physiopathology
keywords: assessment; chemotherapy; neurophysiology; peripheral neuropathy