title: Mild cognitive impairment status and mobility performance: an analysis from the Boston RISE study.
abstract: BACKGROUND
  The prevalence of mild cognitive impairment (MCI) and mobility limitations is high among older adults. The aim of this study was to investigate the association between MCI status and both performance-based and self-report measures of mobility in community-dwelling older adults.
  
  
  METHODS
  An analysis was conducted on baseline data from the Boston Rehabilitative Impairment Study in the Elderly study, a cohort study of 430 primary care patients aged 65 or older. Neuropsychological tests identified participants with MCI and further subclassified those with impairment in memory domains (aMCI), nonmemory domains (naMCI), and multiple domains (mdMCI). Linear regression models were used to assess the association between MCI status and mobility performance in the Habitual Gait Speed, Figure of 8 Walk, Short Physical Performance Battery, and self-reported Late Life Function and Disability Instrument's Basic Lower Extremity and Advanced Lower Extremity function scales.
  
  
  RESULTS
  Participants had a mean age of 76.6 years, and 42% were characterized with MCI. Participants with MCI performed significantly worse than participants without MCI (No-MCI) on all performance and self-report measures (p < .01). All MCI subtypes performed significantly worse than No-MCI on all mobility measures (p < .05) except for aMCI versus No-MCI on the Figure of 8 Walk (p = .054) and Basic Lower Extremity (p = .11). Moreover, compared with aMCI, mdMCI manifested worse performance on the Figure of 8 Walk and Short Physical Performance Battery, and naMCI manifested worse performance on Short Physical Performance Battery and Basic Lower Extremity.
  
  
  CONCLUSIONS
  Among older community-dwelling primary care patients, performance on a broad range of mobility measures was worse among those with MCI, appearing poorest among those with nonmemory MCI.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts. Clinical Research Centre, Hvidovre Hospital, University of Copenhagen, Denmark. mette.merete.pedersen@regionh.dk.
authors.forename: Mette M
authors.initials: MM
authors.lastname: Pedersen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts.
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Holt
authors.affiliation: Psychology Service, VA Boston Healthcare System, Massachusetts. Department of Psychiatry, Boston University School of Medicine, Massachusetts.
authors.forename: Laura
authors.initials: L
authors.lastname: Grande
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Kurlinski
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts. Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.
authors.forename: Marla K
authors.initials: MK
authors.lastname: Beauchamp
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts.
authors.forename: Dan K
authors.initials: DK
authors.lastname: Kiely
authors.affiliation: Clinical Research Centre, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: Janne
authors.initials: J
authors.lastname: Petersen
authors.affiliation: Department of Nursing, University of Massachusetts, Boston.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Leveille
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts. Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Bean
mesh_terms: D000368:Aged; D000375:Aging; D001900:Boston / Q000453:epidemiology; D003071:Cognition / Q000502:physiology* / Q000528:radiation effects*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D051346:Mobility Limitation; D009483:Neuropsychological Tests; D015995:Prevalence; D016138:Walking / Q000502:physiology*
keywords: Cognition; Functional performance; Successful aging.