title: Macroscopic effect of blue light cure on wound healing in NMRI mice NMRI.
abstract: BACKGROUND
  Wound healing is a complex process and has been an ongoing challenge all over the world. Some studies have suggested light cure as a modality to accelerate wound repair. It can induce fibroblast proliferation, increase collagen synthesis and activate cellular processes involved in expression of procollagen type I and III mRNA. This study was designed to assess the macroscopic effect of halogen dental curing blue light on full-thickness open wound healing in NMRI mice.
  
  
  METHODS
  Forty male NMRI mice were divided into control and treatment groups. A full-thickness wound of 6 mm in diameter was induced on the lower back of all mice under general anesthesia and sterile conditions. The mice of the treatment group received a 5-min exposure of halogen light Coltolux II (QHL), 420-500 nm, daily for 7 days. The diameter of the wound was measured in both the treatment and the control groups every second day up to Day 14. Data were analyzed by SPSS version 12 software using Student's t-test. A significance level of P ≤ 0.05 was considered for each comparison.
  
  
  RESULTS
  There was a significant difference in wound diameter between the control and the treatment groups at all measurements after Day 3 (P ≤ 0/05).
  
  
  CONCLUSIONS
  The results of this study suggest improvement of full-thickness wound healing by daily irradiation of halogen dental curing blue light of 420-500 nm for 7 days.
authors.affiliation: Department of Physiology and Biophysics, Islamic Azad University of Tehran, Tehran, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Jaffary
authors.forename: Vahid
authors.initials: V
authors.lastname: Changizi
authors.forename: Homeira
authors.initials: H
authors.lastname: Mardani
authors.forename: Parisa
authors.initials: P
authors.lastname: Kakanezhadian
authors.forename: Faezeh Moshref
authors.initials: FM
authors.lastname: Javadi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Nilforoushzadeh
authors.forename: Elaheh
authors.initials: E
authors.lastname: Haftbaradaran
keywords: Light cure; NMRI mice; wound healing