title: The FTO genotype as a useful predictor of body weight maintenance: initial data from a 5-year follow-up study.
abstract: OBJECTIVE
  We examined associations between the fat-mass and obesity-associated (FTO) gene (rs9939609) and any weight change over a 5-year period following a 14-week lifestyle intervention among middle-aged Japanese women.
  
  
  METHODS
  One hundred twenty-eight Japanese women (BMI >25 kg/m²) participated in a 14-week weight loss intervention between 2004 and 2006. Of the participants, 62 consented to the 5-year follow-up measurement session. Of these women, 47 women who achieved a weight loss of at least 10% from their baseline values during the 14-week intervention were included in the analysis. Body weight, body fat, abdominal fat assessed by CT scans, and metabolic risk factors (i.e., blood pressure, lipids, and glucose) were measured at baseline, post-intervention, and at the 5-year follow-up.
  
  
  RESULTS
  During the 5-year non-intervention period, increases in body weight, fat mass, total abdominal fat, and subcutaneous abdominal fat were significantly greater in subjects with the homozygous minor allele (AA genotype, n=4; 8.5%) than in those with the homozygous major allele (TT genotype, n=31; 66.0%) or heterozygous allele (TA genotype, n=12; 25.5%). In multiple regression analyses, the variation in rs9939609 was a significant and independent predictor (P<0.001) for regaining weight during the 5-year follow-up.
  
  
  CONCLUSIONS
  Our data suggest that Japanese women with the risk allele (AA) of rs9939609 may have more difficulty preventing fat gain from reoccurring after weight loss intervention than women with the other genotypes.
authors.affiliation: Hazard Evaluation and Epidemiology Research Group, National Institute of Occupational Safety and Health, Japan. Electronic address: matsuo.tomoaki11@gmail.com.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Matsuo
authors.affiliation: Faculty of Medicine, University of Tsukuba.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakata
authors.affiliation: Pharmacogenomics Project EBM Research Center, Kyoto University.
authors.forename: Kikuko
authors.initials: K
authors.lastname: Hotta
authors.affiliation: Faculty of Health and Sport Sciences, University of Tsukuba.
authors.forename: Kiyoji
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D050153:Abdominal Fat / Q000473:pathology; D050154:Adiposity; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D006801:Humans; D007564:Japan; D008019:Life Style; D008875:Middle Aged; D009043:Motor Activity; D056128:Obesity, Abdominal / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D050177:Overweight / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D055502:Secondary Prevention; D015430:Weight Gain
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Abdominal Obesity; Genotype; Lifestyle Intervention; Weight Loss