title: Visible light induced fast synthesis of protein-polymer conjugates: controllable polymerization and protein activity.
abstract: Herein visible light is used to induce RAFT polymerization from protein for preparing protein-polymer conjugates at ambient temperature. Polymerization is fast and can be conveniently controlled with irradiation time. By site-specific polymerization of NIPAm to protein, the protein activity is maintained and in certain cases it presents an efficient on-off-switchable property.
authors.affiliation: The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China. chenh@suda.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Gaojian
authors.initials: G
authors.lastname: Chen
authors.forename: David M
authors.initials: DM
authors.lastname: Haddleton
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D055767:Immobilized Proteins / Q000737:chemistry / Q000378:metabolism; D043564:Inorganic Pyrophosphatase / Q000737:chemistry / Q000378:metabolism; D008027:Light; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D055767:Immobilized Proteins; D011108:Polymers; D011506:Proteins; C052970:poly-N-isopropylacrylamide; D043564:Inorganic Pyrophosphatase