title: Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice.
abstract: Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects. We investigated the anti-inflammatory effect of P. eryngii in mice with acute lung injury (ALI). Intranasal instillation of lipopolysaccharide (LPS) (10  μ g/site/mouse) induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid) as well as histopathological damage in the lung, 6 h after treatment. Mice administered heat-treated P. eryngii (0.3-1 g/kg, p.o. (HTPE)) 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage. These results suggest that HTPE has anti-inflammatory effects against ALI. Thus, P. eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection.
authors.affiliation: Mushroom Research Laboratory, Hokuto Corporation, 800-8 Shimokomazawa, Nagano 381-0008, Japan.
authors.forename: Junya
authors.identifier: 0000-0001-7006-5035
authors.initials: J
authors.lastname: Kawai
authors.affiliation: Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Tsugunobu
authors.initials: T
authors.lastname: Andoh
authors.affiliation: Mushroom Research Laboratory, Hokuto Corporation, 800-8 Shimokomazawa, Nagano 381-0008, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ouchi
authors.affiliation: Mushroom Research Laboratory, Hokuto Corporation, 800-8 Shimokomazawa, Nagano 381-0008, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inatomi