title: An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex.
abstract: We report herein the synthesis and application of a novel G-quadruplex-selective luminescent iridium(iii) complex for the construction of an oligonucleotide-based, label-free, rapid and convenient luminescent RNA detection platform.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. edmondma@hkbu.edu.hk.
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Ka-Ho
authors.initials: KH
authors.lastname: Leung
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Zhong
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Liu
authors.forename: Daniel Shiu-Hin
authors.initials: DS
authors.lastname: Chan
authors.forename: Anne
authors.initials: A
authors.lastname: Bourdoncle
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
authors.forename: Hui-Min David
authors.initials: HM
authors.lastname: Wang
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
mesh_terms: D001665:Binding Sites; D015374:Biosensing Techniques; D004277:DNA, Single-Stranded / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D049449:Luminescence; D008163:Luminescent Measurements; D035683:MicroRNAs / Q000737:chemistry; D009154:Mutation; D036103:Nanotechnology / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000032:analysis*; D013696:Temperature
chemical_list: D004277:DNA, Single-Stranded; D035683:MicroRNAs; D009841:Oligonucleotides; D007495:Iridium; D012313:RNA