title: Application status of MALDI-TOF mass spectrometry in the identification and drug resistance of Mycobacterium tuberculosis.
abstract: Characterizing Mycobacterium tuberculosis (MTB) and detecting its drug resistance are challenging for clinical laboratory diagnosis, largely due to its slow growth and higher rate of genetic mutation. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a revolutionary technique for the routine identification of microorganisms. In this review, we discuss the application status of mass spectrometry in the identification and drug resistance of M. tuberculosis.
authors.affiliation: 1 Institute of Clinical Laboratory Medicine, 2 Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Zhang
authors.affiliation: 1 Institute of Clinical Laboratory Medicine, 2 Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Long
authors.affiliation: 1 Institute of Clinical Laboratory Medicine, 2 Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Wenfang
authors.initials: W
authors.lastname: He
authors.affiliation: 1 Institute of Clinical Laboratory Medicine, 2 Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Hao
authors.affiliation: 1 Institute of Clinical Laboratory Medicine, 2 Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Liu
keywords: Mycobacterium tuberculosis (MTB); drug resistance; identification; matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)