title: Palladium-catalyzed asymmetric amination of allenyl phosphates: enantioselective synthesis of allenes with an additional unsaturated unit.
abstract: A highly enantioselective Pd-catalyzed amination of allenyl phosphates generating 2,3-allenyl amines with central chirality has been developed. Under the optimized conditions, chiral 2,3-allenyl amines with or without (an) additional C-C double or triple bond(s) have been prepared at 0 °C with up to 90% yield and 94% ee by identifying (R)-3,4,5-(MeO)3-MeOBIPHEP as the ligand.
authors.affiliation: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang (P.R. China).
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Li
authors.forename: Chunling
authors.initials: C
authors.lastname: Fu
authors.forename: Shengming
authors.initials: S
authors.lastname: Ma
keywords: allenes; amination; asymmetric allenylation; central chirality; palladium