title: Evaluation of some antioxidant enzyme activities (SOD and GPX) and their polymorphisms (MnSOD2 Ala9Val, GPX1 Pro198Leu) in fibromyalgia.
abstract: OBJECTIVE
  Fibromyalgia syndrome (FMS) is a pain syndrome in which common pain in muscle-skeletal system, sleeping disorder and fatigue symptoms coexist. The aim of the present study was to determine SOD and GPX enzyme levels in FMS as well as to investigate possible associations between FMS and Ala9Val polymorphism of MnSOD2 and Pro198Leu polymorphism of GPX1.
  
  
  METHODS
  The study included 127 women FMS patients and 56 healthy subjects. Total SOD and total GPX enzyme activities were determined in patient and control groups. In addition, frequencies of Ala9Val polymorphism of MnSOD2 and Pro198Leu polymorphism of GPX1 were also detected.
  
  
  RESULTS
  SOD enzyme activity was higher in FMS group compared to control (p < 0.001). GPX enzyme activity, on the other hand, was not different between FMS and control groups. No significant differences were found between genotype and allele frequencies of GPX1 and MnSOD2 polymorphisms.
  
  
  CONCLUSIONS
  Elevated total SOD and unchanging total GPX1 activities in FMS patients could be the reason for increased oxidative stress and lipid peroxidation in FMS. Genotype and allele frequencies of Ala9Val polymorphism of MnSOD2 and Pro198Leu polymorphism of GPX1 in FMS have been studied first time in the present study, and no associations were found between them and FMS.
authors.affiliation: Department of Biochemistry, Gaziosmanpasa University Medical Faculty, Tokat, Turkey. draliakbas@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Akbas
authors.forename: A
authors.initials: A
authors.lastname: Inanir
authors.forename: I
authors.initials: I
authors.lastname: Benli
authors.forename: Y
authors.initials: Y
authors.lastname: Onder
authors.forename: L
authors.initials: L
authors.lastname: Aydogan
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000097:blood / Q000235:genetics*; D006801:Humans; D015227:Lipid Peroxidation; D008875:Middle Aged; D018384:Oxidative Stress; D010641:Phenotype; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2; C000722067:GPX1 protein, human