title: Prophylactic pectoralis major muscle flap in prevention of pharyngocutaneous fistula in total laryngectomy after radiotherapy.
abstract: BACKGROUND
  The purpose of this study was to assess the utility of the pectoralis major muscle flap (PMMF) in the prevention of pharyngocutaneous fistula for total laryngectomy after radiotherapy (RT) METHODS: We conducted a retrospective review of 166 patients who underwent a total laryngectomy after RT between 1998 and 2012 at the CHU de Québec.
  
  
  RESULTS
  One hundred fifteen patients underwent a total laryngectomy with primary pharyngeal closure alone and 51 patients received an onlay PMMF. The incidence of pharyngocutaneous fistula in the PMMF group was 14% compared to 36% when only primary closure was done (p = .004). However, the PMMF did not influence the treatment needed for the healing of this complication (p = 1.00). The development of pharyngocutaneous fistula increased the length of stay from 19 to 50 days (p < .0001) and delayed the initiation of oral diet from 15 to 25 days (p = .03).
  
  
  CONCLUSIONS
  Nonirradiated tissue coverage should be routine in total laryngectomy after RT. PMMF is a good adjunct to prevent pharyngocutaneous fistula.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, CHU de Québec, Québec, Canada.
authors.forename: Annie-Kim
authors.initials: AK
authors.lastname: Gendreau-Lefèvre
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, CHU de Québec, Québec, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Audet
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, CHU de Québec, Québec, Canada.
authors.forename: Scott
authors.initials: S
authors.lastname: Maltais
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, CHU de Québec, Québec, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Thuot
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D017577:Cutaneous Fistula / Q000209:etiology / Q000517:prevention & control*; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D010369:Pectoralis Muscles / Q000601:surgery* / Q000637:transplantation; D010608:Pharyngeal Diseases / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control; D011322:Primary Prevention / Q000379:methods; D011792:Quebec; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013524:Surgical Flaps / Q000098:blood supply / Q000637:transplantation*; D016896:Treatment Outcome
keywords: pectoralis major muscle flap; pharyngocutaneous fistula; radiotherapy; salvage laryngectomy; total laryngectomy