title: Antibacterial, antifungal, phytotoxic, and genotoxic properties of two complexes of Ag(I) with sulfachloropyridazine (SCP): X-ray diffraction of [Ag(SCP)]n.
abstract: We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN(-) ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the N(sulfonamide) atom could be coordination sites for the silver ion in the Ag-SCP-SCN complex. The Ag-SCP complex is a polymeric compound with metal-metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for Ag(I) . Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver-SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug-resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver-sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune-deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs.
authors.affiliation: Área Química General, Instituto Química Rosario (IQUIR), Área Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Suipacha 531, 2000 Rosario (Argentina).
authors.forename: Natalia
authors.initials: N
authors.lastname: Mosconi
authors.forename: Cecilia
authors.initials: C
authors.lastname: Giulidori
authors.forename: Francesca
authors.initials: F
authors.lastname: Velluti
authors.forename: Estela
authors.initials: E
authors.lastname: Hure
authors.forename: Agustina
authors.initials: A
authors.lastname: Postigo
authors.forename: Graciela
authors.initials: G
authors.lastname: Borthagaray
authors.forename: Davi Fernando
authors.initials: DF
authors.lastname: Back
authors.forename: María H
authors.initials: MH
authors.lastname: Torre
authors.forename: Marcela
authors.initials: M
authors.lastname: Rizzotto
mesh_terms: D000490:Allium / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D002175:Candida / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009152:Mutagenicity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver / Q000737:chemistry*; D013410:Sulfachlorpyridazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D013861:Thiocyanates / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D013861:Thiocyanates; D012834:Silver; D013410:Sulfachlorpyridazine; C009941:potassium thiocyanate
keywords: allium test; antibacterial agents; antifungal agents; silver; sulfonamides