title: Palladium-catalyzed C(sp2)-H pyridocarbonylation of N-aryl-2-aminopyridines: dual function of the pyridyl moiety.
abstract: An efficient synthesis of 11H-pyrido[2,1-b]quinazolin-11-one through palladium-catalyzed C(sp(2))-H pyridocarbonylation of N-aryl-2-aminopyridines has been developed. The pyridyl group acts as an intramolecular nucleophile for the first time in C-H carbonylation reactions.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Liang
authors.forename: Yimiao
authors.initials: Y
authors.lastname: He
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000631:Aminopyridines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000631:Aminopyridines; D052999:Quinazolinones; D010165:Palladium; C032439:alpha-aminopyridine