title: Recombinant human bone morphogenetic protein-2 promote and stabilize hard and soft tissue healing for large mandibular new bone reconstruction defects.
abstract: Numerous autogenous bone-grafting procedures are available for the recovering of large continuity defects of the mandible. However, these surgical techniques present several limitations involving postoperative morbidity and pain. The development of new bone technique reconstruction not involving autogenous bone graft would offer new opportunities for facial bone reconstruction. This report highlights the possibility of recombinant human bone morphogenetic protein type 2 (rhBMP-2) application without concomitant bone grafting material in the restoration of continuity critical-sized defects after tumor resection in the mandible. The presented case shows a large mandibular reconstruction after tumor removal in a 31-year-old white man affected by ameloblastoma. In this case, the rhBMP-2 application with a carrier consisted on absorbable collagen sponge gives excellent newly formed bone at 18 months of control clinical and radiologic follow-up. The results indicated that the use of rhBMP-2 without concomitant autogenous bone grafting materials in large critical-sized mandibular defects secondary to large mandibular tumor produced excellent regeneration of the treated area.
authors.affiliation: From the *Oral Surgery and Oral Disease Department, School of Dentistry, University of Messina, Messina, Italy; †Department of Oral and Maxillofacial Surgery, Loma Linda University, Loma Linda, CA; ‡School of Dentistry, University of Messina, Messina, Italy; and §Department of Oral Surgery, Policlinico Cà Granda, University of Milan School of Dentistry, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Cicciù
authors.forename: Alan Scott
authors.initials: AS
authors.lastname: Herford
authors.forename: Dominico
authors.initials: D
authors.lastname: Cicciù
authors.forename: Alan
authors.initials: A
authors.lastname: Scott
authors.forename: Domenico
authors.initials: D
authors.lastname: Cicciù
authors.forename: Rahul
authors.initials: R
authors.lastname: Tandon
authors.forename: Carlo
authors.initials: C
authors.lastname: Maiorana
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D064591:Allografts / Q000637:transplantation; D000564:Ameloblastoma / Q000601:surgery*; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D003094:Collagen; D004337:Drug Carriers; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000601:surgery*; D063175:Mandibular Reconstruction / Q000295:instrumentation / Q000379:methods; D010012:Osteogenesis / Q000187:drug effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures / Q000379:methods*; D013526:Surgical Mesh; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
chemical_list: D055396:Bone Morphogenetic Protein 2; D004337:Drug Carriers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen