title: Managing the vitamin A program portfolio: a case study of Zambia, 2013-2042.
abstract: BACKGROUND
  Micronutrient deficiencies continue to constitute a major burden of disease, particularly in Africa and South Asia. Programs to address micronutrient deficiencies have been increasing in number, type, and scale in recent years, creating an ever-growing need to understand their combined coverage levels, costs, and impacts so as to more effectively combat deficiencies, avoid putting individuals at risk for excess intakes, and ensure the efficient use of public health resources.
  
  
  OBJECTIVE
  To analyze combinations of the two current programs--sugar fortification and Child Health Week (CHW)--together with four prospective programs--vegetable oil fortification, wheat flour fortification, maize meal fortification, and biofortified vitamin A maize--to identify Zambia's optimal vitamin A portfolio.
  
  
  METHODS
  Combining program cost estimates and 30-year Zambian food demand projections, together with the Zambian 2005 Living Conditions Monitoring Survey, the annual costs, coverage, impact, and cost-effectiveness of 62 Zambian portfolios were modeled for the period from 2013 to 2042.
  
  
  RESULTS
  Optimal portfolios are identified for each of five alternative criteria: average cost-effectiveness, incremental cost-effectiveness, coverage maximization, health impact maximization, and affordability. The most likely scenario is identified to be one that starts with the current portfolio and takes into account all five criteria. Starting with CHW and sugar fortification, it phases in vitamin A maize, oil, wheat flour, and maize meal (in that order) to eventually include all six individual interventions.
  
  
  CONCLUSIONS
  Combining cost and Household Consumption and Expenditure Survey (HCES) data provides a powerful evidence-generating tool with which to understand how individual micronutrient programs interact and to quantify the tradeoffs involved in selecting alternative program portfolios.
authors.forename: John L
authors.initials: JL
authors.lastname: Fiedler
authors.forename: Keith
authors.initials: K
authors.lastname: Lividini
mesh_terms: D002648:Child; D003362:Cost-Benefit Analysis / Q000191:economics / Q000379:methods / Q000706:statistics & numerical data; D005527:Food, Fortified / Q000191:economics* / Q000706:statistics & numerical data*; D006801:Humans; D015397:Program Evaluation / Q000191:economics / Q000379:methods* / Q000706:statistics & numerical data*; D014801:Vitamin A / Q000191:economics / Q000627:therapeutic use*; D014802:Vitamin A Deficiency / Q000188:drug therapy* / Q000191:economics; D015024:Zambia
chemical_list: D014801:Vitamin A