title: Identifying specific receptors for cargo-mediated autophagy.
abstract: Macroautophagy has been implicated in numerous diseases, yet our understanding of the proteins responsible for the turnover of specific cargo by autophagy is limited. In a recent paper published in Nature, Mancias et al. used quantitative proteomics to identify a cohort of autophagosome-enriched proteins, one of which, nuclear receptor coactivator 4 (NCOA4) was shown to be required for the selective delivery of ferritin to the lysosome, ultimately regulating intracellular iron by autophagic turnover of ferritin, or ferritinophagy.
authors.affiliation: Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Goodall
authors.affiliation: Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Thorburn
mesh_terms: D001343:Autophagy; D005293:Ferritins / Q000378:metabolism*; D006801:Humans; D056918:Nuclear Receptor Coactivators / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism*; D040901:Proteomics
chemical_list: D056918:Nuclear Receptor Coactivators; D005293:Ferritins