title: Association between the XPG Asp1104His and XPF Arg415Gln polymorphisms and risk of cancer: a meta-analysis.
abstract: BACKGROUND
  The XPG (xeroderma pigmentosum type G) Asp1104His and XPF (xeroderma pigmentosum type F) Arg415Gln polymorphisms had been implicated in cancer susceptibility. The previous published data on the association between XPG Asp1104His and XPF Arg415Gln polymorphisms and cancer risk remained controversial.
  
  
  RESULTS
  To derive a more precise estimation of the association between the XPG Asp1104His and XPF Arg415Gln polymorphisms and overall cancer risk, we performed a meta-analysis to investigate the association between cancer susceptibility and XPG Asp1104His (32,162 cases and 39,858 controls from 66 studies) and XPF Arg415Gln polymorphisms (17,864 cases and 20,578 controls from 32 studies) in different inheritance models. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11). In the further stratified and sensitivity analyses, significantly decreased lung cancer risk was found for XPF Arg415Gln (dominant model: OR = 0.82, 95% CI = 0.71-0.96; Arg/Gln versus Arg/Arg: OR = 0.83, 95% CI = 0.71-0.97; additive model: OR = 0.83, 95% CI = 0.72-0.95) and significantly increased other cancer risk was found among hospital-based studies for XPG Asp1104His (dominant model: OR = 1.23, 95% CI = 1.02-1.49).
  
  
  CONCLUSIONS
  In summary, this meta-analysis suggests that XPF Arg415Gln polymorphism may be associated with decreased lung cancer risk and XPG Asp1104His may be a low-penetrant risk factor in some cancers development. And larger scale primary studies are required to further evaluate the interaction of XPG Asp1104His and XPF Arg415Gln polymorphisms and cancer risk in specific populations.
authors.affiliation: Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.affiliation: Department of Clinical Biochemistry, Affiliated Hospital of Guiyang Medical University, Guiyang, China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Liu
authors.affiliation: Department of Hematology, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biological Chemistry, Changzhi Medical College, Changzhi, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Hematology, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Su-Lan
authors.initials: SL
authors.lastname: Wang
authors.affiliation: Department of Hematology, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Xu-Liang
authors.initials: XL
authors.lastname: Shen
authors.affiliation: Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Xian-Bin
authors.initials: XB
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020125:Mutation, Missense; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D014157:Transcription Factors / Q000235:genetics*; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5