title: Management of necrotizing pneumonia and pulmonary gangrene: a case series and review of the literature.
abstract: BACKGROUND
  Necrotizing pneumonia is an uncommon but severe complication of bacterial pneumonia, associated with high morbidity and mortality. The availability of current data regarding the management of necrotizing pneumonia is limited to case reports and small retrospective observational cohort studies. Consequently, appropriate management for these patients remains unclear.
  
  
  OBJECTIVE
  To describe five cases and review the available literature to help guide management of necrotizing pneumonia.
  
  
  METHODS
  Cases involving five adults with respiratory failure due to necrotizing pneumonia admitted to a tertiary care centre and infected with Streptococcus pneumoniae (n=3), Klebsiella pneumoniae (n=1) and methicillin-resistant Staphylococcus aureus (n=1) were reviewed. All available literature was reviewed and encompassed case reports and retrospective reviews dating from 1975 to the present.
  
  
  RESULTS
  All five patients received aggressive medical management and consultation by thoracic surgery. Three patients underwent surgical procedures to debride necrotic lung parenchyma. Two of the five patients died in hospital.
  
  
  CONCLUSIONS
  Necrotizing pneumonia often leads to pulmonary gangrene. Computed tomography of the thorax with contrast is recommended to evaluate the pulmonary vascular supply. Further study is necessary to determine whether surgical intervention, in the absence of pulmonary gangrene, results in better outcomes.
authors.forename: Neela
authors.initials: N
authors.lastname: Chatha
authors.forename: Dalilah
authors.initials: D
authors.lastname: Fortin
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Bosma
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005734:Gangrene / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000628:therapy