title: Intestinal macrophages and dendritic cells: what's the difference?
abstract: Mononuclear phagocytes (MPs) in the murine intestine, comprising dendritic cells (DCs) and macrophages (Mϕs), perform disparate yet complementary immunological functions. Functional analyses of these distinct MP subsets have been complicated by the substantial overlap in their surface phenotypes. Here, we review recent findings that have enabled more accurate definition of these MP subsets. We discuss these recent advances in the context of the current understanding of the functions of DCs and Mϕs in the maintenance of intestinal homeostasis, and how their functions may alter when homeostasis is disrupted.
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
authors.forename: Vuk
authors.initials: V
authors.lastname: Cerovic
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
authors.forename: Calum C
authors.initials: CC
authors.lastname: Bain
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
authors.forename: Allan M
authors.initials: AM
authors.lastname: Mowat
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK. Electronic address: simon.milling@glasgow.ac.uk.
authors.forename: Simon W F
authors.initials: SW
authors.lastname: Milling
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism
keywords: dendritic cells; intestine; macrophages; mouse