title: Base-catalyzed bicyclization of dialkyl glutaconates with cinnamoylacetamides: a synthetic strategy for isoquinolinedione derivatives.
abstract: We report here that polysubstituted dihydroisoquinolones and isoquinolones can be constructed by the one-pot reaction of the readily available acyclic α,β-unsaturated carbonyl precursors and dialkyl glutaconates under mild basic conditions (1-45 min for the former vs. 1-6 h for the latter) via the domino process involving [3+3] annulation/intramolecular aza-cyclization.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China. zhaoyl351@nenu.edu.cn liuqun@nenu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Zhao
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Yi-Jin
authors.initials: YJ
authors.lastname: Li
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000468:Alkalies / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D005977:Glutarates / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000081:Acetamides; D000468:Alkalies; D001372:Aza Compounds; D005977:Glutarates; D007546:Isoquinolines; C010971:glutaconic acid