title: Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.
abstract: A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
authors.affiliation: School of Pharmacy, Faculty of Life Sciences, University College London, London WC1N 1AX, United Kingdom.
authors.forename: Christopher R M
authors.initials: CR
authors.lastname: Asquith
authors.affiliation: Clinical Laboratory and Center of Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland.
authors.forename: Marina L
authors.initials: ML
authors.lastname: Meli
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation.
authors.forename: Lidia S
authors.initials: LS
authors.lastname: Konstantinova
authors.affiliation: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
authors.forename: Tuomo
authors.initials: T
authors.lastname: Laitinen
authors.affiliation: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
authors.forename: Mikael
authors.initials: M
authors.lastname: Peräkylä
authors.affiliation: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Poso
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation.
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Rakitin
authors.affiliation: Veterinary Clinical Sciences, Royal Veterinary College, Hatfield AL9 7TA, United Kingdom.
authors.forename: Karin
authors.initials: K
authors.lastname: Allenspach
authors.affiliation: Clinical Laboratory and Center of Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland.
authors.forename: Regina
authors.initials: R
authors.lastname: Hofmann-Lehmann
authors.affiliation: School of Pharmacy, Faculty of Life Sciences, University College London, London WC1N 1AX, United Kingdom. Electronic address: s.hilton@ucl.ac.uk.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Hilton
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000378:metabolism*; D002415:Cats; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013843:Thiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D036022:Capsid Proteins; D011758:Pyrroles; D054852:Small Molecule Libraries; D013843:Thiazines
keywords: FIV; HIV-1; NCp7; Nucleocapsid protein; Scorpionine