title: The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-guided Therapy.
abstract: Despite efforts to standardize molecular diagnostic tests, performance differences are not rare. Laboratories are challenged in situations where treatment rules have been established using a reference assay that is different from the assays being used in daily practice. Assessing the viral load status of patients with chronic hepatitis C under modern triple therapy is a recognized example. We demonstrate the use of the range of uncertainty as an easy and efficient tool that can provide information on the certainty of a test result's interpretation in the context of making hepatitis C virus treatment decisions.
authors.affiliation: Abbott GmbH and Co KG, Wiesbaden, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Jülicher
authors.affiliation: Abbott GmbH and Co KG, Wiesbaden, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Dhein
keywords: hepatitis C; in vitro diagnostic tests; precision; response guided therapy; standardization; viral load