title: Pharmacologic modalities in the treatment of osteoradionecrosis of the jaw.
abstract: Managing osteoradionecrosis (ORN) of the facial bones is a challenge in maxillofacial head and neck surgery. Changes in understanding of ORN of the jaws has led to new studies using novel therapeutic modalities to manage this disorder. These treatment regimens may allow medical management to replace major reconstructive surgery for some patients who have already undergone chemoradiotherapy or combined modality therapy for head and neck cancer.
authors.affiliation: Maxillofacial/Head and Neck Surgery, The Royal Marsden Hospital, London, UK; UK RCS/BAOMS/Saving Faces Maxillofacial Surgical Specialty Lead for Research, London, UK. Electronic address: jim.mccaul@mac.com.
authors.forename: James Anthony
authors.initials: JA
authors.lastname: McCaul
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D059248:Chemoradiotherapy; D004002:Clodronic Acid / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D007571:Jaw Diseases / Q000188:drug therapy*; D056948:Orthognathic Surgical Procedures; D010025:Osteoradionecrosis / Q000188:drug therapy*; D010431:Pentoxifylline / Q000627:therapeutic use; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D019651:Plastic Surgery Procedures; D024505:Tocopherols / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D050071:Bone Density Conservation Agents; D011837:Radiation-Protective Agents; D004002:Clodronic Acid; D024505:Tocopherols; D010431:Pentoxifylline
keywords: Clodronate; Osteoradionecrosis; Pentoxifylline; Radiation-induced fibroatrophy; Tocopherol