title: Role of structural changes induced in biological membranes by hydrolysable tannins from sumac leaves (Rhus typhina L.) in their antihemolytic and antibacterial effects.
abstract: In this study, we found that the sumac tannins (Rhus typhina L.) exert to a various extent antihemolytic effects and antibacterial activity against Bacillus cereus and Pseudomonas aeruginosa depending on structural specificity of bacteria and different mechanisms of their toxic action. The sumac tannins exert the most expressed activity against B. cereus. The antihemolytic effect of the sumac tannins seems to be connected to a greater extent with their modifying action on the erythrocyte membrane structure. It was found that the sumac tannins are incorporated into the erythrocyte membrane, causing transformation of discocytes into echinocytes and enhancing the rigidity of the hydrophilic region of the lipid bilayer. We suggest that the embedding of sumac tannins into the membrane of erythrocytes alters their physical properties and, as a consequence, can limit their interaction with bacterial toxins.
authors.affiliation: Department of Biophysics, University of Bialystok, Swierkowa 20 B, 15-950, Białystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Olchowik-Grabarek
authors.forename: Izabela
authors.initials: I
authors.lastname: Swiecicka
authors.forename: Zhanna
authors.initials: Z
authors.lastname: Andreeva-Kovaleskaya
authors.forename: Alexander
authors.initials: A
authors.lastname: Solonin
authors.forename: Dorota
authors.initials: D
authors.lastname: Bonarska-Kujawa
authors.forename: Halina
authors.initials: H
authors.lastname: Kleszczyńska
authors.forename: Saidmukhtar
authors.initials: S
authors.lastname: Mavlyanov
authors.forename: Maria
authors.initials: M
authors.lastname: Zamaraeva
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011549:Pseudomonas / Q000187:drug effects; D029045:Rhus / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D047348:Hydrolyzable Tannins; D010936:Plant Extracts