title: [A case of intracranial invasion from sinonasal small cell neuroendocrine carcinoma].
abstract: Sinonasal neuroendocrine carcinomas (NECs) are rare tumors. We present a rare case of intracranial invasion of sinonasal small-cell NEC. A 61-year-old woman with nasal obstruction and bleeding was referred to our hospital. Computed tomography showed a polyp-like tumor occupying her left nasal cavity and extending to the paranasal sinuses and anterior cranial fossa. The tumor was removed using a transfacial approach by otolaryngologists and a bifrontal cranial approach by neurosurgeons. In histopathological analyses, we found that the tumor presented with both an epithelial and neuroendocrine nature, and was diagnosed as a small-cell NEC. Post-surgery, she received localized radiation therapy and chemotherapy, and is alive, 18 months after diagnosis. In cases where it is difficult to perform a differential diagnosis of tumors arising from the frontal cranial base and extending to the nasal and cranial sides, NEC should be considered as a possibility.
authors.affiliation: Department of Neurosurgery, Kagawa Prefectural Central Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ono
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hisamatsu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuramoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Katsumata
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Kawauchi
authors.forename: Kengo
authors.initials: K
authors.lastname: Kanai
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000532:radiotherapy / Q000601:surgery*; D002541:Cerebral Decortication; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed