title: Trajectory and risk factors for chemotherapy-induced nausea and vomiting in Asian patients with head and neck cancer.
abstract: BACKGROUND
  The purpose of this study was to analyze the trajectory of and risk factors for chemotherapy-induced nausea and vomiting in Asian patients with head and neck cancer.
  
  
  METHODS
  Adult patients with head and neck cancer scheduled to receive cisplatin-based chemotherapy were recruited for the study. Clinical events were collated from standardized diaries.
  
  
  RESULTS
  Two hundred thirty-five patients were included in the analyses. The majority (75.7%) was men, Chinese (81.7%), and manifested nasopharyngeal cancer (83.4%). The overall incidence of significant nausea and vomiting was 73.7% and 24.7%, respectively, with single-day cisplatin regimens of 48.9% and 28.9%, respectively, with the multiple-day cisplatin regimen. Patients using complementary alternative medicine were less likely than others to achieve a complete response to antiemetics.
  
  
  CONCLUSIONS
  Although postchemotherapy vomiting is relatively well controlled in Asian patients with head and neck cancer, postchemotherapy nausea remains problematic in this population.
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.|Department of Pharmacy, National Cancer Centre Singapore, Singapore.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Chan
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
authors.forename: Maung
authors.initials: M
authors.lastname: Shwe
authors.affiliation: Department of Pharmacy, National Cancer Centre Singapore, Singapore.
authors.forename: Yanxiang
authors.initials: Y
authors.lastname: Gan
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
authors.forename: Kevin
authors.initials: K
authors.lastname: Yap
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.|Department of Pharmacy, National Cancer Centre Singapore, Singapore.
authors.forename: Lita
authors.initials: L
authors.lastname: Chew
authors.affiliation: Department of Medical Oncology, National Cancer Centre Singapore, Singapore.
authors.forename: Wan-Teck
authors.initials: WT
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002173:Cancer Care Facilities; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000208:ethnology; D002681:China; D015331:Cohort Studies; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000208:ethnology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology
keywords: antiemetics; cancer; chemotherapy; chemotherapy-induced nausea and vomiting; head and neck cancer