title: Prostate cancer: surgery versus observation for localized prostate cancer.
abstract: A key study comparing radical prostatectomy and watchful waiting for prostate cancer has been updated with extended follow-up observation, demonstrating substantial benefits of surgery for reduced mortality mainly in younger men, but also reduced requirement for palliative treatment in older men. These findings should be interpreted within the current scenario of prostate cancer diagnosis and treatment.
authors.affiliation: Department of Urology, Utrecht University Medical Centre, Homeruslaan 24-1, Utrecht 3581MH, Netherlands.
authors.forename: Roderick C N
authors.initials: RC
authors.lastname: van den Bergh
authors.affiliation: Department of Urology, University of Bern, Inselspital, Freiburgstrasse, Bern 3010, Switzerland.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Giannarini
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D057832:Watchful Waiting
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen