title: Mast cells in renal inflammation and fibrosis: lessons learnt from animal studies.
abstract: Mast cells are hematopoietic cells involved in inflammation and immunity and have been recognized also as important effector cells in kidney inflammation. In humans, only a few mast cells reside in kidneys constitutively but in progressive renal diseases their numbers increase substantially representing an essential part of the interstitial infiltrate of inflammatory cells. Recent data obtained in experimental animal models have emphasized a complex role of these cells and the mediators they release as they have been shown both to promote, but also to protect from disease and fibrosis development. Sometimes conflicting results have been reported in similar models suggesting a very narrow window between these activities depending on the pathophysiological context. Interestingly in mice, mast cell or mast cell mediator specific actions became also apparent in the absence of significant mast cell kidney infiltration supporting systemic or regional actions via draining lymph nodes or kidney capsules. Many of their activities rely on the capacity of mast cells to release, in a timely controlled manner, a wide range of inflammatory mediators, which can promote anti-inflammatory actions and repair activities that contribute to healing, but in some circumstances or in case of inappropriate regulation may also promote kidney disease.
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Lydia Celia
authors.initials: LC
authors.lastname: Madjene
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Maguelonne
authors.initials: M
authors.lastname: Pons
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Luca
authors.initials: L
authors.lastname: Danelli
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Claver
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Liza
authors.initials: L
authors.lastname: Ali
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Iris K
authors.initials: IK
authors.lastname: Madera-Salcedo
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Asma
authors.initials: A
authors.lastname: Kassas
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pellefigues
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Marquet
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Dadah
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Tarik
authors.initials: T
authors.lastname: Attout
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France; Department of Pediatric Surgery and Urology, Hopital Robert-Debré, APHP, University Paris Diderot, Sorbonne Paris Cite, Paris, France.
authors.forename: Alaa
authors.initials: A
authors.lastname: El-Ghoneimi
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Gautier
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Benhamou
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Charles
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France; Département Hospitalo Universitaire (DHU) FIRE, Paris, France; Service de Néphrologie, Hôpital Universitaire Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris, Paris 75018, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Daugas
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Launay
authors.affiliation: INSERM UMRS 1149, Paris 75018, France; CNRS ERL 8252, Paris 75018, France; University Paris Diderot, Sorbonne Paris Cite, Laboratoire d'excellence INFLAMEX, Paris 75018, France. Electronic address: ulrich.blank@inserm.fr.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Blank
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000276:immunology* / Q000473:pathology*; D008181:Lupus Nephritis / Q000276:immunology / Q000473:pathology; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D051436:Renal Insufficiency, Chronic / Q000276:immunology* / Q000473:pathology*
keywords: Fibrosis lupus nephritis; Mast cell chymase; Mast cells; Renal disease