title: Delivering the promise of SFC: a case study.
abstract: During the past years there has been a rapid development in supercritical fluid chromatography (SFC) instrumentation making it a highly efficient and robust technique. Although much is written about the advantages of SFC over liquid chromatography (LC), there are not many direct comparisons detailing the gain in purification throughput, the savings in solvent consumption and the reduced environmental impact for large-scale SFC applications. We will show that a research scale separation laboratory built to handle multigram amounts can be used for kilogram separations when moving from LC to SFC.
authors.affiliation: Medicinal Chemistry RIA, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden. Electronic address: maria.lindskog@astrazeneca.com.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Lindskog
authors.affiliation: Medicinal Chemistry RIA, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden.
authors.forename: Hanna
authors.initials: H
authors.lastname: Nelander
authors.affiliation: Medicinal Chemistry RIA, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden.
authors.forename: Anna C
authors.initials: AC
authors.lastname: Jonson
authors.affiliation: Medicinal Chemistry RIA, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden.
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Halvarsson
mesh_terms: D002853:Chromatography, Liquid; D025924:Chromatography, Supercritical Fluid / Q000191:economics / Q000295:instrumentation / Q000379:methods; D003365:Costs and Cost Analysis; D004777:Environment; D012997:Solvents / Q000737:chemistry / Q000191:economics
chemical_list: D012997:Solvents