title: [The tumoral stroma, a breeding ground for cancer cells].
abstract: Carcinomas are constituted by malignant epithelial cells and the tumor microenvironment also called tumoral stroma. The present non-exhaustive review will focus on cellular and molecular key events implicating cancer-associated fibroblasts (CAF) and the extracellular matrix (ECM) in the stroma remodeling processes occuring during tumor invasive steps. We will also discuss the place of the stroma in the cancerology today, the recent progresses done and its usefulness to design new therapies.
authors.affiliation: Institut de génétique et de biologie moléculaire et cellulaire (IGBMC), département de génomique fonctionnelle et cancer, 1, rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France - CNRS UMR 7104, Inserm U964, université de Strasbourg, 67404 Illkirch Cedex, France.
authors.forename: Émilie
authors.initials: É
authors.lastname: Buache
authors.affiliation: Institut de génétique et de biologie moléculaire et cellulaire (IGBMC), département de génomique fonctionnelle et cancer, 1, rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France - CNRS UMR 7104, Inserm U964, université de Strasbourg, 67404 Illkirch Cedex, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Rio
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment