title: Malignant transformation of an odontogenic cyst in a period of 10 years.
abstract: Primary intraosseous carcinoma of the jaws (PIOSCC) might arise from odontogenic epithelium, more commonly from a previous odontogenic cyst. The aim of this case is to illustrate that the clinician should consider that an apparent benign dentigerous cyst can suffer malignant transformation and that all material removed from a patient must be evaluated histologically. A 44-year-old man presented in a routine periapical X-ray an impacted lower left third molar with radiolucency over its crown. Ten years later, the patient complained of pain in the same region and the tooth was extracted. After one month, the patient still complained of pain and suffered a fracture of the mandible. A biopsy was performed and carcinoma was diagnosed. The patient was treated surgically with adjuvant radio- and chemotherapy and after 8 years, he is well without signs of recurrences. This report describes a central mandibular carcinoma probably developed from a previous dentigerous cyst.
authors.affiliation: Stomatology Department, School of Dentistry, São Paulo University, São Paulo, SP, Brazil.
authors.forename: Juliane Pirágine
authors.initials: JP
authors.lastname: Araújo
authors.affiliation: Head and Neck Surgery and Otorhinolaryngology Department, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors.forename: Luiz Paulo
authors.initials: LP
authors.lastname: Kowalski
authors.affiliation: Head and Neck Surgery and Otorhinolaryngology Department, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors.forename: Mônica Lúcia
authors.initials: ML
authors.lastname: Rodrigues
authors.affiliation: Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.affiliation: Pathology Department, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors.forename: Clovis Antonio
authors.initials: CA
authors.lastname: Lopes Pinto
authors.affiliation: Stomatology Department, School of Dentistry, São Paulo University, São Paulo, SP, Brazil ; Stomatology Department, AC Camargo Cancer Center, Rua Professor Antônio Prudente, 211 Liberdade, 01509-010 São Paulo, SP, Brazil.
authors.forename: Fabio Abreu
authors.initials: FA
authors.lastname: Alves