title: Assessing the effect of laser beam width on quantitative evaluation of optical properties of intraocular lens implants.
abstract: The design and manufacture of intraocular lenses (IOLs) depend upon the identification and quantitative preclinical evaluation of key optical properties and environmental parameters. The confocal laser method (CLM) is a new technique for measuring IOL optical properties, such as dioptric power, optical quality, refractive index, and geometrical parameters. In comparison to competing systems, the CLM utilizes a fiber-optic confocal laser design that significantly improves the resolution, accuracy, and repeatability of optical measurements. Here, we investigate the impact of changing the beam diameter on the CLM platform for the evaluation of IOL dioptric powers. Due to the Gaussian intensity profile of the CLM laser beam, the changes in focal length and dioptric power associated with changes in beam diameter are well within the tolerances specified in the ISO IOL standard. These results demonstrate some of the advanced potentials of the CLM toward more effectively and quantitatively evaluating IOL optical properties.
authors.affiliation: Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Bennett N
authors.initials: BN
authors.lastname: Walker
authors.affiliation: Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Robert H
authors.initials: RH
authors.lastname: James
authors.affiliation: Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Aurin
authors.initials: A
authors.lastname: Chakravarty
authors.affiliation: Office of Device Evaluation, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Don
authors.initials: D
authors.lastname: Calogero
authors.affiliation: Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Ilko K
authors.initials: IK
authors.lastname: Ilev
mesh_terms: D007834:Lasers; D007910:Lenses, Intraocular; D018613:Microscopy, Confocal / Q000295:instrumentation / Q000379:methods*; D055095:Optics and Photonics / Q000295:instrumentation / Q000379:methods*