title: Assessment of lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1, interleukin-6, homocysteine, and uric acid levels in patients with psoriasis.
abstract: BACKGROUND
  Chronic inflammation may play a role in psoriasis pathogenesis. Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers. However, both the roles of these markers and the pathogenesis of psoriasis are unknown.
  
  
  OBJECTIVE
  The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.
  
  
  METHODS
  Fifty-six patients with psoriasis and 33 healthy controls were included in the study. Serum concentrations of the markers were evaluated by ELISA. The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients. Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.
  
  
  RESULTS
  The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp., P < 0.001, P < 0.05). The others showed no significant differences between psoriasis and the control groups (all of them P > 0.05). The mean PASI score in the patient group was 8.3 ± 6.5.
  
  
  CONCLUSIONS
  These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.
authors.affiliation: Department of Dermatology, Konya Training and Research Hospital, Meram, 42023 Konya, Turkey.
authors.forename: Arzu
authors.identifier: 0000-0001-5372-0712
authors.initials: A
authors.lastname: Ataseven
authors.affiliation: Department of Microbiology, Faculty of Medicine, Afyon Kocatepe University, 03200 Afyon, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Kesli
authors.affiliation: Department of Dermatology, Konya Training and Research Hospital, Meram, 42023 Konya, Turkey.
authors.forename: Gulcan Saylam
authors.initials: GS
authors.lastname: Kurtipek
authors.affiliation: Department of Dermatology, Faculty of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
authors.forename: Perihan
authors.initials: P
authors.lastname: Ozturk
mesh_terms: D000209:Acute-Phase Proteins; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D051152:Clusterin / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000097:blood*; D011565:Psoriasis / Q000097:blood*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C495242:CLU protein, human; D051152:Clusterin; C508600:IL6 protein, human; D015850:Interleukin-6; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D047888:Receptors, Tumor Necrosis Factor, Type I; D006710:Homocysteine; D014527:Uric Acid