title: Transoral laser microsurgery for laryngeal carcinoma: Survival analysis in a hospital-based population.
abstract: BACKGROUND
  Although already established for treatment for early-stage laryngeal cancers, transoral laser microsurgery indications for more advanced tumors are not unanimous. Additionally, no outcomes concerning the Portuguese population are currently accessible.
  
  
  METHODS
  Outcomes of 248 patients presenting laryngeal carcinoma primarily treated by transoral laser microsurgery with curative intention in tertiary referral center were retrospectively evaluated and compared with concerning literature.
  
  
  RESULTS
  For supraglottic tumors (23 stage I-II and 20 stage III-IV), 5-year disease-specific survival (DSS) was, respectively, 88.4% and 72.7%, and the total larynx-preservation rate was 90.7%. For glottic cancer (165 stage I-II and 40 stage III-IV), 5-year DSS was, respectively, 96.5% and 90.8% and the larynx preservation rate was 88.3%.
  
  
  CONCLUSIONS
  Transoral laser microsurgery, alone or with neck dissection and adjuvant therapy, is an efficient procedure for treatment of laryngeal cancer in different stages. To the best of our knowledge, this is the first study reporting transoral laser microsurgery outcomes in the Portuguese population.
authors.affiliation: Department of Otolaryngology, Portuguese Institute of Oncology Dr Francisco Gentil, Porto, Portugal.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Breda
authors.affiliation: Department of Molecular Oncology GRP CI, Portuguese Institute of Oncology Dr Francisco Gentil, Porto, Portugal.
authors.forename: Raquel
authors.initials: R
authors.lastname: Catarino
authors.affiliation: Department of Otolaryngology, Portuguese Institute of Oncology Dr Francisco Gentil, Porto, Portugal.
authors.forename: Eurico
authors.initials: E
authors.lastname: Monteiro
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology; D006785:Hospitals, University; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D007828:Laryngoscopy / Q000379:methods; D053685:Laser Therapy / Q000379:methods; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D037981:Neck Dissection; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments / Q000379:methods; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: functional outcome; glottic laryngeal carcinoma oncologic result; organ preservation; supraglottic laryngeal carcinoma oncologic result; transoral laser microsurgery