title: Long-term progression of retinal vasculitis in Behçet patients using a fluorescein angiography scoring system.
abstract: BACKGROUND
  To evaluate the long-time progression of retinal vasculitis in Behçet patients using the fluorescein angiography (FA) scoring system.
  
  
  METHODS
  Retrospective study was conducted for 71 eyes of 43 patients who met the study criteria. All patients completed at least 2 years of follow-up. FA was taken during the periods of active retinal vasculitis and the quiescent phase, and analyzed using a FA scoring system. Among nine categories, the four most prevalent FA signs were evaluated: optic disc hyperfluorescence (score 0-3), macular edema (score 0-4), retinal vascular staining and/or leakage (score 0-7), and capillary leakage (score 0-10).
  
  
  RESULTS
  Mean number of total active inflammations was 2.6 ± 1.5 times during mean 55.0 ± 20.0 months. Mean scores at the first active inflammation were 1.8 ± 1.0 for optic disc hyperfluorescence, 2.4 ± 1.0 for macular edema, 5.3 ± 2.1 for retinal vascular staining and/or leakage, and 5.8 ± 3.2 for capillary leakage. Mean total FA score was 17.4 ± 6.8. Mean scores at the first quiescent phase were 0.6 ± 0.4 for optic disc hyperfluorescence, 1.1 ± 1.2 for macular edema, 3.8 ± 1.9 for retinal vascular staining and/or leakage, and 3.5 ± 3.5 for capillary leakage. Mean total FA score was 9.1 ± 5.0. Mean scores for each active inflammation and quiescent phase were not significantly changed, and mean FA scores were significantly reduced in quiescent phase (P = 0.003 for optic disc hyperfluorescence, P = 0.005 for macular leakage, P = 0.010 for retinal vascular staining and/or leakage, P = 0.008 for capillary leakage, and P = 0.018 for total FA score; paired t-test).
  
  
  CONCLUSIONS
  Retinal vasculitis of Behçet patients did not significantly progress during long-term follow-up.
authors.affiliation: Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul, Republic of Korea.
authors.forename: Hae Min
authors.initials: HM
authors.lastname: Kang
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Lee
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001813:Blood-Retinal Barrier; D002199:Capillary Permeability; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D031300:Retinal Vasculitis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents