title: Anti-M antibodies as a cause of intrauterine fetal death and neonatal hyperbilirubinaemia.
abstract: A preterm male infant (35 weeks), appropriate for gestational age with birth weight of 2.20 kg was born to a 28-year G2 P0 mother. The mother's blood group was A positive and the father's was B positive. Her first pregnancy was an intrauterine fetal death due to immune hydrops. The mother's blood was positive for indirect Coomb's test with 1:32 dilution and anti-M antibodies. This pregnancy was induced at 35 weeks of gestation. Investigations from the cord blood revealed A positive blood group, positive direct Coomb's test, haematocrit of 41.4%, cord reticulocyte count of 5.3% and total serum bilirubin (TSB) of 2.7 mg/dL. Phototherapy was started at 27 h of life for visible jaundice. In view of progressive pallor and a sudden rise of bilirubin, the infant was subjected to exchange transfusion on day 5 of life. The transfusion was given with O negative and anti-M antibodies negative donor blood. Total serum bilirubin (TSB) prior to exchange transfusion was 28 mg/dL and packed cell volume (PCV) was 21%. Phototherapy was continued for a total duration of 8 days.
authors.affiliation: Department of Neonatology, Fernandez Hospital, Hyderabad, Andhra Pradesh, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.forename: Anuradha
authors.initials: A
authors.lastname: Murki
authors.forename: Srinivas
authors.initials: S
authors.lastname: Murki
authors.forename: Tejo
authors.initials: T
authors.lastname: Pratap
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D003298:Coombs Test; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology*; D051556:Hyperbilirubinemia, Neonatal / Q000209:etiology* / Q000628:therapy*; D007075:Immunoglobulin M / Q000276:immunology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008951:MNSs Blood-Group System / Q000276:immunology; D008297:Male; D010789:Phototherapy; D011247:Pregnancy
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007075:Immunoglobulin M; D008951:MNSs Blood-Group System