title: Natural products from mangrove actinomycetes.
abstract: Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. The mangrove ecosystem is becoming a hot spot for natural product discovery and bioactivity survey. Diverse mangrove actinomycetes as promising and productive sources are worth being explored and uncovered. At the time of writing, we report 73 novel compounds and 49 known compounds isolated from mangrove actinomycetes including alkaloids, benzene derivatives, cyclopentenone derivatives, dilactones, macrolides, 2-pyranones and sesquiterpenes. Attractive structures such as salinosporamides, xiamycins and novel indolocarbazoles are highlighted. Many exciting compounds have been proven as potential new antibiotics, antitumor and antiviral agents, anti-fibrotic agents and antioxidants. Furthermore, some of their biosynthetic pathways have also been revealed. This review is an attempt to consolidate and summarize the past and the latest studies on mangrove actinomycetes natural product discovery and to draw attention to their immense potential as novel and bioactive compounds for marine drugs discovery.
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. xudongbo@whu.edu.cn.
authors.forename: Dong-Bo
authors.initials: DB
authors.lastname: Xu
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. yy_ww1001@163.com.
authors.forename: Wan-Wan
authors.initials: WW
authors.lastname: Ye
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. hanying0928@whu.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zxdeng@whu.edu.cn.
authors.forename: Zi-Xin
authors.initials: ZX
authors.lastname: Deng
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. kuihong31@whu.edu.cn.
authors.forename: Kui
authors.initials: K
authors.lastname: Hong
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D032407:Avicennia / Q000382:microbiology*; D001688:Biological Products / Q000737:chemistry*; D043982:Rhizophoraceae / Q000382:microbiology*
chemical_list: D001688:Biological Products