title: Association of osteopontin with osteoarthritis.
abstract: The joint disease osteoarthritis (OA) is the most common form of arthritis, which mainly affects the older people. OA is becoming one of the major non-fatal health burdens of the world. The etiology of OA is mostly unclear, and it cannot be cured totally. Osteopontin (OPN) is a multifunctional phosphoprotein, of which overexpression and high level of presence in synovial fluid and articular cartilage were found to be associated with OA progression. Usually, in OA progression, OPN plays important role as an intrinsic regulator. Recent studies have taken attempt to use this protein as a diagnostic marker of OA and use OPN as a target for the drug development against OA. This review summarizes the role of OPN in OA, with focusing on the mechanism of action, and also discussing the diagnostic and therapeutic aspects of OA related to OPN.
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Cheng
authors.forename: Shuguang
authors.initials: S
authors.lastname: Gao
authors.forename: Guanghua
authors.initials: G
authors.lastname: Lei
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007596:Joints / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D058990:Molecular Targeted Therapy; D053495:Osteopontin / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D018836:Inflammation Mediators; D053495:Osteopontin