title: Quantification of myocardial perfusion using cardiac magnetic resonance imaging correlates significantly to rubidium-82 positron emission tomography in patients with severe coronary artery disease: a preliminary study.
abstract: BACKGROUND
  Aim was to compare absolute myocardial perfusion using cardiac magnetic resonance imaging (CMRI) based on Tikhonov's procedure of deconvolution and rubidium-82 positron emission tomography (Rb-82 PET).
  
  
  METHODS
  Fourteen patients with coronary artery stenosis underwent rest and adenosine stress imaging by 1.5-Tesla MR Scanner and a mCT/PET 64-slice Scanner. CMRI were analyzed based on Tikhonov's procedure of deconvolution without specifying an explicit compartment model using our own software. PET images were analyzed using standard clinical software. CMRI and PET data was compared with Spearman's rho and Bland-Altman analysis.
  
  
  RESULTS
  CMRI results were strongly and significantly correlated with PET results for the absolute global myocardial perfusion differences (r=0.805, p=0.001) and for global myocardial perfusion reserve (MPR) (r=0.886, p<0.001). At vessel territorial level, CMRI results were also significantly correlated with absolute PET myocardial perfusion differences (r=0.737, p<0.001) and MPR (r=0.818, p<0.001). Each vessel territory had similar strong correlation for absolute myocardial perfusion differences (right coronary artery (RCA): r=0.787, p=0.001; left anterior descending artery (LAD): r=0.796, p=0.001; left circumflex artery (LCX): r=0.880, p<0.001) and for MPR (RCA: r=0.895, p<0.001; LAD: r=0.886, p<0.001; LCX: r=0.886, p<0.001).
  
  
  CONCLUSIONS
  On a global and vessel territorial basis, CMRI-measured absolute myocardial perfusion differences and MPR were strongly and significantly correlated with the Rb-82 PET findings.
authors.affiliation: Department of Cardiology & Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: abbas.ali.qayyum@regionh.dk.
authors.forename: Abbas A
authors.initials: AA
authors.lastname: Qayyum
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: philip.hasbak@regionh.dk.
authors.forename: Philip
authors.initials: P
authors.lastname: Hasbak
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark; Functional Imaging Unit, Diagnostic Department, Glostrup Hospital, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Ndr. Ringvej 57, 2600 Copenhagen, Denmark. Electronic address: henrik.larsson@regionh.dk.
authors.forename: Henrik B W
authors.initials: HBW
authors.lastname: Larsson
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: thomas.emil.christensen@regionh.dk.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Christensen
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: adam.ali.ghotbi@regionh.dk.
authors.forename: Adam A
authors.initials: AA
authors.lastname: Ghotbi
authors.affiliation: Department of Cardiology & Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: anders.b.mathiasen@gmail.com.
authors.forename: Anders B
authors.initials: AB
authors.lastname: Mathiasen
authors.affiliation: Department of Cardiology & Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: niels.vejlstrup@regionh.dk.
authors.forename: Niels G
authors.initials: NG
authors.lastname: Vejlstrup
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: andreas.kjaer@regionh.dk.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjaer
authors.affiliation: Department of Cardiology & Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: jens.kastrup@regionh.dk.
authors.forename: Jens
authors.initials: J
authors.lastname: Kastrup
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology*; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012414:Rubidium Radioisotopes / Q000493:pharmacokinetics; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D019275:Radiopharmaceuticals; D012414:Rubidium Radioisotopes
keywords: Cardiac magnetic resonance imaging; Coronary artery disease; Myocardial perfusion imaging; Positron emission tomography; Rubidium-82