title: Poly(basic red 9) doped functionalized multi-walled carbon nanotubes as composite films for neurotransmitters biosensors.
abstract: This paper discusses the electrochemical polymerization of basic dye films, which are composed of basic red 9 (BR9), on various electrodes and the enhancement of the electropolymerization by functionalized multiwall carbon nanotubes (f-MWCNTs) modification of the electrode surface. The presence of f-MWCNTs enhances the surface coverage (Γ) and stability. Poly(BR9) films were electrocatalytically active for epinephrine and serotonin oxidation. The electrocatalytic oxidation current developed from the anodic peak of the redox couple. Electrochemical impedance spectroscopy (EIS) was applied to monitor the whole process of the electrode modification. EIS can provide useful information regarding the impedance changes on the electrode surface between each step. We studied the surface morphology of the composite film using scanning electron microscopy (SEM) and atomic force microscopy (AFM), which revealed that BR9 is doped on f-MWCNTs. Cyclic voltammetry (CV) was used for the measurement of the electroanalytical properties of the analytes. The sensitivity values for the f-MWCNTs/BR9 composite film were higher than the poly(BR9) and f-MWCNTs composite film. Finally, differential pulse voltammetry (DPV) was used for the detection of a mixture of analytes at the f-MWCNTs/BR9 composite film. We simulated a more complex system with both serotonin and epinephrine present simultaneously. This system also exhibited oxidation peaks for serotonin in bovine calf serum (BCS) and epinephrine injection for real samples determination at pH 7.0 at the f-MWCNTs/BR9 composite film.
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: M Ajmal
authors.initials: MA
authors.lastname: Ali
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: smchen78@ms15.hinet.net.
authors.forename: Shen-Ming
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC.
authors.forename: Shin-Ying
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Chemistry Division, Center for General Education, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC. Electronic address: blou@mail.cgu.edu.tw.
authors.forename: Bih-Show
authors.initials: BS
authors.lastname: Lou
authors.affiliation: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Fahad M A
authors.initials: FM
authors.lastname: Al-Hemaid
mesh_terms: D015374:Biosensing Techniques; D002384:Catalysis; D004396:Coloring Agents / Q000737:chemistry*; D058266:Dielectric Spectroscopy; D055664:Electrochemical Techniques; D004566:Electrodes; D004837:Epinephrine / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D018625:Microscopy, Atomic Force; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D018377:Neurotransmitter Agents / Q000032:analysis*; D011108:Polymers / Q000737:chemistry*; D012394:Rosaniline Dyes / Q000737:chemistry*; D012701:Serotonin / Q000032:analysis
chemical_list: D004396:Coloring Agents; D037742:Nanotubes, Carbon; D018377:Neurotransmitter Agents; D011108:Polymers; D012394:Rosaniline Dyes; D012701:Serotonin; D004837:Epinephrine
keywords: Basic red 9; Bionanotechnology; Composite film; Epinephrine; Multi-wall carbon nanotubes; Serotonin