title: Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls.
abstract: Controllable biomineralization modification of cisplatin can alter the drug biodistribution with extended circulation time in blood. These changes increase passive tumor target and decrease non-specific accumulation significantly, which can improve chemotherapeutic effect with minimum side effects.
authors.affiliation: Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xueyao
authors.initials: X
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Chen
authors.forename: Guangchuan
authors.initials: G
authors.lastname: Wang
authors.forename: Cuilian
authors.initials: C
authors.lastname: Liu
authors.forename: Xurong
authors.initials: X
authors.lastname: Xu
authors.forename: Ruikang
authors.initials: R
authors.lastname: Tang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage*; D004337:Drug Carriers; D004705:Endocytosis; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D009368:Neoplasm Transplantation; D010316:Particle Size; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D002945:Cisplatin
keywords: biodistribution; biomineralization; cisplatin; nanoparticles; size effects