title: A visual ERP study of impulse inhibition following a zaleplon-induced nap after sleep deprivation.
abstract: The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD) were examined by event-related brain potentials. Sixteen adult participants performed a Go/NoGo task at five time points: (1) baseline; (2) after 30 h of SD; (3) upon sudden awakening, also called 2 h post-drug; (4) 4 h post-drug; and (5) 6 h post-drug. Behavior results show an increase in both reaction time and false alarm rates after SD and sudden awakening, and a marked decrease at 4 h and 6 h post-drug in zaleplon and placebo conditions. However, no difference was observed between the zaleplon condition and the placebo condition. In event-related potential (ERP) reults compared with results obtained under control conditions, NoGo-P3 latencies significantly increased, whereas the Nogo-P3 amplitude decreased after 30 h of SD and sudden awakening in both the zaleplon condition and the placebo condition. These results indicate that SD attenuates resource allocation and error monitoring for NoGo stimuli. In addition, NoGo-P3 latencies were longer in the zaleplon condition compared with the placebo condition at sudden awakening. Additionally, the NoGo-P3 latencies were shorter in the zaleplon condition than in the placebo condition at 4 h and 6 h post-drug. These results indicate that zaleplon at a dose of 10 mg/day may help subjects achieve a better recovery or maintain better impulse inhibition function, although the side effects of zaleplon last at least 2 h post-drug.
authors.affiliation: Department of Psychology, Fourth Military Medical University, Xi'an Shaanxi, China; Department of Rehabilitative Physioltherapy of Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi, China.
authors.forename: Qianru
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Psychology, Fourth Military Medical University, Xi'an Shaanxi, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Clinical Psychology, Air Force General Hospital, Beijing, China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Qi
authors.affiliation: Institute of Basic Medical Sciences, Academy of Military Medical Science, Beijing, China.
authors.forename: Yongqi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Psychology, Fourth Military Medical University, Xi'an Shaanxi, China.
authors.forename: Tianli
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Rehabilitative Physioltherapy of Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Psychology, Fourth Military Medical University, Xi'an Shaanxi, China.
authors.forename: Xufeng
authors.initials: X
authors.lastname: Liu
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D004334:Drug Administration Schedule; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012892:Sleep Deprivation / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D000081:Acetamides; D011743:Pyrimidines; C085665:zaleplon