title: Synthetic protocol toward fused pyrazolone derivatives via a Michael addition and reductive ring closing strategy.
abstract: A new class of pyrazolo[3,4-c]pyridine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy. These fused heterocycles were accessed from simple starting materials such as nitroolefins and 3-ethoxycarbonyl(methylene)pyrazoline-5-one. The pyrazolo-fused heterocycles were obtained in good overall yields.
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven , Celestijnenlaan 200F, 3001 Leuven, Belgium.
authors.forename: Nikita
authors.initials: N
authors.lastname: Parekh
authors.forename: Joice
authors.initials: J
authors.lastname: Thomas
authors.forename: Jubi
authors.initials: J
authors.lastname: John
authors.forename: Radhika
authors.initials: R
authors.lastname: Kusurkar
authors.forename: Wim M
authors.initials: WM
authors.lastname: De Borggraeve
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
mesh_terms: D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D047069:Pyrazolones; D011728:Pyridones