title: Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy.
abstract: Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Ran
authors.initials: R
authors.lastname: Namgung
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Yeong
authors.initials: Y
authors.lastname: Mi Lee
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Yuna
authors.initials: Y
authors.lastname: Jang
authors.affiliation: Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 700-421, Korea.
authors.forename: Byung-Heon
authors.initials: BH
authors.lastname: Lee
authors.affiliation: 1] Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 700-421, Korea [2] Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea.
authors.forename: In-San
authors.initials: IS
authors.lastname: Kim
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Pandian
authors.initials: P
authors.lastname: Sokkar
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Rhee
authors.affiliation: 1] Bioengineering Department, University of Washington, Seattle, Washington 98195, USA [2] Department of Biochemistry and Cell Biology, WCU Program, School of Medicine, Kyungpook National University, Daegu 700-421, Korea.
authors.forename: Allan S
authors.initials: AS
authors.lastname: Hoffman
authors.affiliation: 1] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002482:Cellulose / Q000009:adverse effects / Q000627:therapeutic use*; D003505:Cyclodextrins / Q000009:adverse effects / Q000627:therapeutic use*; D004337:Drug Carriers / Q000627:therapeutic use*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000627:therapeutic use*; D011108:Polymers / Q000009:adverse effects / Q000627:therapeutic use; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D011108:Polymers; C041953:cyclodextrin polymer; D002482:Cellulose; D017239:Paclitaxel