title: [The epigenome in neurological disorders: a new marker for understanding neuronal dysfunction].
abstract: An epigenome is a chemical modification pattern of genomic DNA that determines the on/off status of genes, and its abnormalities are known to cause congenital diseases. Recent studies have shown that epigenomic patterns are altered by various environmental factors, indicating that epigenomic abnormalities also cause acquired mental and neurological diseases. An epigenomic pattern that reflects past environmental insults is an epigenomic signature. Therefore, it will be used as a marker for preemptive medicine in that it is not based on the population but is instead based on individuals.
authors.affiliation: Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kubota
authors.forename: Takae
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Kunio
authors.initials: K
authors.lastname: Miyake
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000502:physiology; D044127:Epigenesis, Genetic / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D023281:Genomics; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis / Q000235:genetics*
chemical_list: D005819:Genetic Markers