title: Deconvolution of isotope signals from bundles of multiple hairs.
abstract: Segmental analysis of hair has been used in diverse fields ranging from forensics to ecology to measure the concentration of substances such as drugs and isotopes. Multiple hairs are typically combined into a bundle for segmental analysis to obtain a high-resolution series of measurements. Individual hair strands cycle through multiple phases of growth and grow at different rates when in the growth phase. Variation in growth of hair strands in a bundle can cause misalignment of substance concentration between hairs, attenuating the primary body signal. We developed a mathematical model based on the known physiology of hair growth to describe the signal averaging caused by bundling multiple hairs for segmental analysis. The model was used to form an inverse method to estimate the primary body signal from measurements of a hair bundle. The inverse method was applied to a previously described stable oxygen isotope chronology from the hair of a murder victim and provides a refined interpretation of the data. Aspects of the reconstruction were confirmed when the victim was later identified.
authors.affiliation: National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, TN, 37996, USA, cremien@nimbios.org.
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Remien
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Adler
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Chesson
authors.forename: Luciano O
authors.initials: LO
authors.lastname: Valenzuela
authors.forename: James R
authors.initials: JR
authors.lastname: Ehleringer
authors.forename: Thure E
authors.initials: TE
authors.lastname: Cerling
mesh_terms: D019548:Crime Victims; D006197:Hair / Q000737:chemistry* / Q000254:growth & development*; D006708:Homicide; D006801:Humans; D007554:Isotopes / Q000032:analysis*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D007554:Isotopes; D004364:Pharmaceutical Preparations