title: Protective effects of Jiashen Prescription () on myocardial infarction in rats.
abstract: OBJECTIVE
  To evaluate the effects of Jiashen Prescription (, JSP) on myocardial infarction (MI) size and cardiac function at the early stage of MI in rats.
  
  
  METHODS
  One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle, JSP 3 and 6 g/(kg·d), or losartan 10 mg/(kg·d) for 1 week.
  
  
  RESULTS
  Compared with the vehicle-treated MI rats, 6 g/(kg·d) JSP reduced MI size 3 days after MI (P<0.05), and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI (P<0.05). In addition, 6 g/(kg·d) JSP and losartan were equally effective in reducing MI size and enhancing cardiac functional recovery.
  
  
  CONCLUSIONS
  JSP reduces MI size and improves cardiac function after MI, suggesting that JSP has potential as a therapy for MI.
authors.affiliation: Division of Cardiology and Central Laboratory, First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China, zhumingjun317@163.com.
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Zhu
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Shi-Yang
authors.initials: SY
authors.lastname: Xie
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Yong-Xia
authors.initials: YX
authors.lastname: Wang
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Bo-Li
authors.initials: BL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001835:Body Weight; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006334:Heart Function Tests; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D017207:Rats, Sprague-Dawley; D016019:Survival Analysis; D014463:Ultrasonography
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; C000605767:jiashen