title: Failure of recovery from lead induced hepatoxicity and disruption of erythrocyte antioxidant defence system in Wistar rats.
abstract: Lead acetate (PbA) is one of the major environmental contaminants with grave toxicological consequences both in the developing and developed countries. The liver and erythrocyte antioxidant status and markers of oxidative were assessed. Exposure of rats to PbA led to significant decline (p < 0.05) in hepatic and erythrocyte glutathione peroxidase (GPx), glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH) content. Similarly, malondialdehyde (MDA) and H(2)O(2) concentrations were significantly (p < 0.05) elevated. Histopathology and immunohistology of liver of rats exposed to PbA showed focal areas of necrosis and COX-2 expression after 6 weeks of PbA withdrawal. Taken together, hepatic and erythrocytes antioxidant defence system failed to recover after withdrawal of the exposed PbA for the period of the study. In conclusion, experimental animals exposed to PbA did not recover from hepatotoxicity and disruption of erythrocyte antioxidant defence system via free radical generation and oxidative stress.
authors.affiliation: Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
authors.forename: Temidayo O
authors.initials: TO
authors.lastname: Omobowale
authors.affiliation: Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria. Electronic address: ademolaoyagbemi@yahoo.com.
authors.forename: Ademola A
authors.initials: AA
authors.lastname: Oyagbemi
authors.affiliation: Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
authors.forename: Akinleye S
authors.initials: AS
authors.lastname: Akinrinde
authors.affiliation: Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
authors.forename: Adebowale B
authors.initials: AB
authors.lastname: Saba
authors.affiliation: Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
authors.forename: Oluwabusola T
authors.initials: OT
authors.lastname: Daramola
authors.affiliation: Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
authors.forename: Blessing S
authors.initials: BS
authors.lastname: Ogunpolu
authors.affiliation: Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
authors.forename: James O
authors.initials: JO
authors.lastname: Olopade
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006400:Hematocrit; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009942:Organometallic Compounds / Q000633:toxicity*; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004785:Environmental Pollutants; D009942:Organometallic Compounds; D002374:Catalase; D005979:Glutathione Peroxidase; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; C008261:lead acetate
keywords: COX-2; Erythrocyte; Hepatotoxicity; Lead acetate; Liver; Oxidative stress