title: Determination of the presence and pharmacokinetic profile of ciprofloxacin by TLC and HPLC method respectively in broiler chicken after single oral administration.
abstract: The objective of this study was to determine the presence of ciprofloxacin and pharmacokinetics of ciprofloxacin in blood plasma of broiler chicken after single oral administration at feeding state. Ciprofloxacin was administered orally at 10 mg kg(-1) to each of the 10 broiler chickens at feeding state. Presence of ciprofloxacin was determined by TLC method and pharmacokinetics by HPLC method. Peak plasma concentration (Cmax) of ciprofloxacin, 0.26±0.03 mg l(-1) was achieved at 4.40±0.1 h (Tmax). Biological half-life of ciprofloxacin was 5.25±0.02 h. Area under the curve (AUC) was 13.397±0.13 mg ml(-1) h, elimination rate constant was 0.13±0.02 h(-1), volume of distribution was 0.194±0.04 l kg(-1) and bioavailability was 49±0.48%. On the basis of the results of the present study, we conclude that, feeding state may have a vital effect on the pharmacokinetic profile of ciprofloxacin in broiler blood plasma.
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
authors.forename: Md Mustahsan
authors.initials: MM
authors.lastname: Billah
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
authors.forename: S M Masud
authors.initials: SM
authors.lastname: Rana
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
authors.forename: Mohammad Salim
authors.initials: MS
authors.lastname: Hossain
authors.affiliation: Department of Physiology, Biochemistry and Pharmacology, Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh.
authors.forename: A K M
authors.initials: AK
authors.lastname: Saifuddin
authors.affiliation: Department of Physiology, Biochemistry and Pharmacology, Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh.
authors.forename: S K M Azizul
authors.initials: SK
authors.lastname: Islam
authors.affiliation: Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
authors.forename: Zannatul
authors.initials: Z
authors.lastname: Naim
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
authors.forename: Santanu
authors.initials: S
authors.lastname: Barua
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002645:Chickens; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002855:Chromatography, Thin Layer / Q000379:methods*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004435:Eating; D006207:Half-Life; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin