title: Synthesis of carbazoles by copper-catalyzed intramolecular C-H/N-H coupling.
abstract: A Cu-catalyzed intramolecular C-H amination for the synthesis of carbazoles has been developed. The key to success is the installation of the picolinamide-based directing group, which is spontaneously removed after the coupling event. The Cu catalysis proceeded smoothly under Pd- and I(III)-free conditions, and its mild oxidation aptitude enables the rapid and concise construction of heteroatom-incorporated carbazole core π-systems.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Koji
authors.initials: K
authors.lastname: Hirano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Satoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
mesh_terms: D000577:Amides / Q000737:chemistry; D000586:Amination; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*
chemical_list: D000577:Amides; D002227:Carbazoles; D010848:Picolinic Acids; C041514:carbazole; D010165:Palladium; D003300:Copper; C003142:picolinamide