title: Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain.
abstract: Neural stem cells in the adult mammalian hippocampus continuously generate new functional neurons, which modify the hippocampal network and significantly contribute to cognitive processes and mood regulation. Here, we show that the development of new neurons from stem cells in adult mice is paralleled by extensive changes to mitochondrial mass, distribution, and shape. Moreover, exercise-a strong modifier of adult hippocampal neurogenesis-accelerates neuronal maturation and induces a profound increase in mitochondrial content and the presence of mitochondria in dendritic segments. Genetic inhibition of the activity of the mitochondrial fission factor dynamin-related protein 1 (Drp1) inhibits neurogenesis under basal and exercise conditions. Conversely, enhanced Drp1 activity furthers exercise-induced acceleration of neuronal maturation. Collectively, these results indicate that adult hippocampal neurogenesis requires adaptation of the mitochondrial compartment and suggest that mitochondria are targets for enhancing neurogenesis-dependent hippocampal plasticity.
authors.affiliation: Research Group Adult Neurogenesis and Neural Stem Cells, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Munich-Neuherberg, Germany, Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany, and F. Hoffmann-La Roche Ltd, CNS Discovery, Pharma Research and Early Development, CH-4070 Basel, Switzerland.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Steib
authors.forename: Iris
authors.initials: I
authors.lastname: Schäffner
authors.forename: Ravi
authors.initials: R
authors.lastname: Jagasia
authors.forename: Birgit
authors.initials: B
authors.lastname: Ebert
authors.forename: D Chichung
authors.initials: DC
authors.lastname: Lie
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000254:growth & development*; D002452:Cell Count; D002454:Cell Differentiation / Q000502:physiology; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D049229:Dendritic Spines / Q000502:physiology / Q000648:ultrastructure; D034281:Dynamins / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D013238:Stereotaxic Techniques
chemical_list: C486391:Dnm1l protein, mouse; D034281:Dynamins
keywords: Activity; adult hippocampal neurogenesis; exercise; mitochondria; stem cells