title: Cholesterol metabolism-associated molecules in late onset Alzheimer's disease.
abstract: Alzheimers disease (AD) is the most common cause of dementia and, with an aging population, poses a huge public health problem. Although a small per cent is caused by single gene changes, most AD is sporadic and unexplained. Of many modifying factors, changes in brain cholesterol homeostasis are the best studied. We present a review of the role of altered cholesterol metabolism and hypercholesterolemia in APP processing and Abeta generation. We also provide an overview of the potential pharmacological modulation of cholesterol homeostasis in the brain by cholesterol-lowering agents and beta-cyclodextrins.
authors.affiliation: Department of Psychology, Section of Neuroscience and Neurobiology Research Center D. Bovet, Sapienza University of Rome, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Fiorenza
authors.affiliation: Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Dardis
authors.affiliation: Department of Psychology, Section of Neuroscience and Neurobiology Research Center D. Bovet, Sapienza University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Canterini
authors.affiliation: Department of Pediatrics, University of Arizona, Tucson, AZ, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Erickson