title: ANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane.
abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides is an important cause of rapidly progressive glomerulonephritides (RPGN), and they are classically described as pauci-immune diseases as evidenced by the absence of immune deposits on immunofluoresence microscopy of the kidney biopsy. We report two patients with RPGN, pulmonary-renal syndrome, positive ANCA serology and linear Immunoglobulin G (IgG) staining on glomerular basement membrane in the absence of detectable anti-glomerular basement membrane (anti-GBM) antibodies in the serum.
authors.forename: Wiroon
authors.initials: W
authors.lastname: Sangsiraprapha
authors.forename: Luan
authors.initials: L
authors.lastname: Truong
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Sreedhar
authors.initials: S
authors.lastname: Mandayam
mesh_terms: D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005455:Fluorescent Antibody Technique; D050533:Glomerular Basement Membrane / Q000276:immunology*; D005921:Glomerulonephritis / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D006470:Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents