title: Hemostasis control in dental extractions in patients receiving oral anticoagulant therapy: an approach with calcium sulfate.
abstract: The aim of this study was to evaluate the use of calcium sulfate (CaS) as a hemostatic agent after tooth extraction in patients with anticoagulant drug therapy. A total of 30 patients undergoing anticoagulant therapy (22 women and 8 men) with a mean age of 54.6 years (SD = 9.2 years), needing dental extractions, were selected for this study. They were divided into 2 groups, control (group 1) and test (group 2), in a randomized way. In group 1 patients, the postextraction socket was managed with obliterative suture only. Group 2 patients were treated with CaS placed into the postextraction sockets. All the patients did not interrupt the anticoagulant therapy during the dental treatment. The healing pattern was found to be approximately similar in all treatment groups, showing significant improvement at each consecutive visit. However, a statistically significant difference in the adequate hemostasis was evident between groups 1 and 2 (P = 0.0056). The use of CaS helped to control the bleeding from inside the socket, producing instantly a very good hemostasis. Further studies are necessary to confirm the simplicity, possibilities, and limits of the proposed procedure.
authors.affiliation: From the *Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy; †Department of Oral Rehabilitation, School of Dental Medicine, Tel-Aviv University, Israel; and ‡Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Scarano
authors.forename: Bruna
authors.initials: B
authors.lastname: Sinjari
authors.forename: Giovanna
authors.initials: G
authors.lastname: Murmura
authors.forename: Eitan
authors.initials: E
authors.lastname: Mijiritsky
authors.forename: Flavia
authors.initials: F
authors.lastname: Iaculli
authors.forename: Carmen
authors.initials: C
authors.lastname: Mortellaro
authors.forename: Stefano
authors.initials: S
authors.lastname: Tetè
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002133:Calcium Sulfate / Q000627:therapeutic use*; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000517:prevention & control; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D014081:Tooth Extraction / Q000009:adverse effects; D020390:Tooth Socket / Q000601:surgery; D014859:Warfarin / Q000008:administration & dosage / Q000627:therapeutic use; D058106:Wound Closure Techniques; D014945:Wound Healing / Q000502:physiology
chemical_list: D000925:Anticoagulants; D006490:Hemostatics; D014859:Warfarin; D002133:Calcium Sulfate