title: Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats.
abstract: Liver is the main site in the body for intense metabolism and excretion. A number of chemicals and drugs which are used routinely cause liver damage. The present study investigates the antihepatotoxic effect of Physalis peruviana whole ripe fruit, water and ethanol extracts of fruit in normal as well as in carbon tetrachloride (CCl(4)) intoxicated rats. The CCl(4) treated rats showed marked elevation in liver enzymes: alanine transaminse, aspratate transaminase, alkaline phosphatase, lactate dehydrogenase and other biochemical parameters: bilirubin, creatinine and urea, thus indicating liver injury. Whereas animal treated/fed with various preparations of Physalis peruviana showed significant lowering effect (p<0.05) in the elevated levels of serum markers like ALAT, ASAT, ALP, LDH, creatinine, urea and bilirubin indicating the protection against hepatic cell damage. The water extract of Physalis peruviana showed highest activity in both rat models while ripe fruit and ethanol extract showed moderate activity compared to standard drug.
authors.affiliation: Biotechnology and Drug Development Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Darakhshan
authors.initials: D
authors.lastname: Taj
authors.affiliation: Biotechnology and Drug Development Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Hira
authors.initials: H
authors.lastname: Khan
authors.affiliation: Biotechnology and Drug Development Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Viqar
authors.initials: V
authors.lastname: Sultana
authors.affiliation: Postharvest Technology Laboratory, Department of Food Science & Technology, University of Karachi, Karachi, Pakistan.
authors.forename: Jehan
authors.initials: J
authors.lastname: Ara
authors.forename: Syed
authors.initials: S
authors.lastname: Ehteshamul-Haque
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005260:Female; D005638:Fruit; D008099:Liver / Q000187:drug effects*; D032321:Physalis; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase