title: Mild oxidation of tosylmethylisocyanide to tosylmethylisocyanate: utility in synthetic and medicinal chemistry.
abstract: A convenient and efficient (one-step) oxidation is reported of commercially available tosylmethylisocyanide (TOSMIC) to form tosylmethylisocyanate, making this highly reactive bifunctional molecule a readily available synthetic reagent. Besides engaging in nucleophilic addition reactions with alcohols, amines and thiols, tosylmethylisocyanate also reacts with carboxylic acids to form tosylmethylamides, which undergo substitution reactions in the presence of organocopper and organomagnesium reagents.
authors.affiliation: Department of Chemistry & Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301.
authors.forename: Hoang V
authors.initials: HV
authors.lastname: Le
authors.affiliation: Department of Chemistry & Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301.
authors.forename: Bruce
authors.initials: B
authors.lastname: Ganem
keywords: Isonitrile-based Multicomponent reactions; Tosylmethylamide; Tosylmethylisocyanate; Tosylmethylisocyanide; p-Toluenesulfonylmethyl isocyanate