title: Pathogenicity mechanisms and host response during oral Candida albicans infections.
abstract: Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or immunosuppression. In recent years, identification of fungal factors contributing to host cell damage and new insights into host defense mechanisms have significantly extended our understanding of the pathogenesis of oral candidiasis. In this review, we will provide an overview of the pathogenicity mechanisms during oral Candida infections and discuss some approaches by which this knowledge could be transferred into therapeutic approaches.
authors.affiliation: Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute Jena (HKI), Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: Betty
authors.initials: B
authors.lastname: Hebecker
authors.forename: Julian R
authors.initials: JR
authors.lastname: Naglik
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hube
authors.forename: Ilse D
authors.initials: ID
authors.lastname: Jacobsen
mesh_terms: D002176:Candida albicans / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D018928:Immunity, Mucosal; D012307:Risk Factors
keywords: adhesion; damage; epithelial cells; immunosuppression; infection models; innate immunity; invasion