title: [Preparation of colon target pellets of Pulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion].
abstract: OBJECTIVE
  To prepare colon target pellets of Pulsatilla total saponins.
  
  
  METHODS
  Pulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion was prepared by the water solution-mixing method. Then plain pills of inclusion were prepared by the granulation-spheronization method, and coated by Glatt fluid bed.
  
  
  RESULTS
  The dissolution of plain pills of Pulsatilla total saponins at 2 h was 16.0%, while that of plain pills of inclusion at 0.5 h was 91.9%. With Eudragit S100 as the coating material, TEC as the plasticizer and talcum power as the anti-adherent, when the coating weight was 12%, the coating efficiency was high, with almost no bonding and drug release of coated pellets in artificial gastric juice for 2 h. The accumulated drug release in artificial intestinal fluid for 4 h was less than 15%, and that in artificial colon fluid for 4 h was more than 90%.
  
  
  CONCLUSIONS
  Coated pellets of Pulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion showed a good colon targeted drug release in vitro, thus could be further developed to be oral colon targeted preparations.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Guan
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Zhu
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Hong-Ning
authors.initials: HN
authors.lastname: Liu
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000042:Absorption; D040761:Biomimetic Materials / Q000378:metabolism; D003106:Colon / Q000378:metabolism*; D004339:Drug Compounding / Q000379:methods*; D004343:Drug Implants; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D031946:Pulsatilla / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000378:metabolism*; D013499:Surface Properties; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004343:Drug Implants; D012503:Saponins; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin