title: Palladium-catalyzed one-pot synthesis of quinazolinones via tert-butyl isocyanide insertion.
abstract: A novel palladium-catalyzed three-component reaction for the synthesis of quinazolin-4(3H)-ones from readily available 2-aminobenzamides and aryl halides via a palladium-catalyzed isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs quinazolin-4(3H)-ones in moderate to excellent yields with the advantages of operational simplicity.
authors.affiliation: College of Pharmaceutical Sciences, Soochow University , Suzhou, 215123, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jiang
authors.forename: Ting
authors.initials: T
authors.lastname: Tang
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Zhu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001549:Benzamides; D009570:Nitriles; D052999:Quinazolinones; D010165:Palladium; C099535:tert-butyl isocyanide