title: Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range.
abstract: OBJECTIVE
  The aim of this study was to examine the relationship between whole-body insulin-mediated glucose disposal and the fasting plasma glucose concentration in nondiabetic individuals.
  
  
  METHODS
  Two hundred fifty-three nondiabetic subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance received a 75-g oral glucose tolerance test and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG and NGT individuals and was related to fasting and 2-hour plasma glucose concentrations in each group.
  
  
  RESULTS
  TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2-hour plasma glucose (PG; r = 0.40, P < .0001) but not with the fasting PG. When IFG and NGT individuals were stratified based on their 2-hour PG concentration, the increase in 2-hour PG was associated with a progressive decrease in TGD in both groups, and the TGD was comparable among NGT and IFG individuals.
  
  
  CONCLUSIONS
  The present results indicate the following: 1) as in NGT, insulin-stimulated TGD varies considerably in IFG individuals; 2) the large variability in TGD in IFG and NGT individuals is related to the 2-hour PG concentration; and 3) after adjustment for the 2-hour proglucagon concentration, IFG subjects have comparable TGD with NGT individuals.
authors.affiliation: Diabetes Division (D.W., L.N., R.A., M.F., A.H.-D., D.T., R.A.D., C.P.J., M.A.-G.), University of Texas Health Science Center at San Antonio, Texas 78229; and Division of Diabetes (M.K.), Istanbul Medipol University, 34810 Istanbul, Turkey.
authors.forename: Diedre
authors.initials: D
authors.lastname: Winner
authors.forename: Luke
authors.initials: L
authors.lastname: Norton
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kanat
authors.forename: Ruth
authors.initials: R
authors.lastname: Arya
authors.forename: Marcel
authors.initials: M
authors.lastname: Fourcaudot
authors.forename: Andrea
authors.initials: A
authors.lastname: Hansis-Diarte
authors.forename: Devjit
authors.initials: D
authors.lastname: Tripathy
authors.forename: Ralph A
authors.initials: RA
authors.lastname: DeFronzo
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Jenkinson
authors.forename: Muhammad
authors.initials: M
authors.lastname: Abdul-Ghani
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000378:metabolism; D015309:Glucose Clamp Technique / Q000379:methods / Q000592:standards; D018149:Glucose Intolerance / Q000378:metabolism; D005951:Glucose Tolerance Test / Q000379:methods* / Q000592:standards*; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D011236:Prediabetic State / Q000378:metabolism; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon