title: Peripartum heart failure caused by left ventricular diastolic dysfunction: a case report.
abstract: Peripartum cardiomyopathy is a rare but potentially life-threatening condition. The current definition of peripartum cardiomyopathy only includes patients with systolic dysfunction. We describe a 25-year-old nulligravid patient with heart failure, i.e. left ventricular diastolic dysfunction with preserved systolic dysfunction during the third trimester of pregnancy. She complained of dyspnea and was referred to our hospital at 31 weeks of gestation. The patient met the clinical criteria for peripartum cardiomyopathy with the exception of systolic dysfunction. Brain-type natriuretic peptide levels peaked at 1447 pg/dL. The patient responded to therapy for heart failure and showed resolution of her diastolic dysfunction by 1 month postpartum. The case demonstrated the important role of diastolic dysfunction in peripartum heart failure and the possibility of clarifying the pathophysiology of peripartum cardiomyopathy by evaluating diastolic function. Further investigations are needed to provide evidence regarding the clinical role of diastolic dysfunction in peripartum heart failure.
authors.affiliation: Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kakogawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nako
authors.forename: Suguru
authors.initials: S
authors.lastname: Igarashi
authors.forename: Shin
authors.initials: S
authors.lastname: Nakamura
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D058725:Peripartum Period; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000503:physiopathology*; D011263:Pregnancy Trimester, Third; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*
keywords: Peripartum heart failure; brain-type natriuretic peptide; diastolic dysfunction; peripartum cardiomyopathy; pregnancy