title: Two pairs of monozygotic twins with concordant acute lymphoblastic leukemia (ALL): case report.
abstract: The occurrence of leukemia in twins is rare but has a crucial implication in the genetic research of leukemia. This report presents 2 pairs of monozygotic twins with precursor B-cell acute lymphoblastic leukemia. Mixed lineage leukemia (MLL)-AF4 fusion genes were found in the twin sisters. This study is the first to report on infant ALL harboring the 46,XY, -4, +10, -13, del(14)(q24), -15, +2mar[4 cells] complex chromosome abnormality. Our report showed that the unified cytogenetic features in monozygotic twins and MLL-AF4 fusion gene may be necessary but insufficient for the clinical development and prognosis of identical twins with leukemia.
authors.affiliation: Department of Pediatrics, Qilu Hospital, Shandong University, Shandong, Ji'nan, P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Nianzheng
authors.initials: N
authors.lastname: Sun
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Huang
authors.forename: Xiuli
authors.initials: X
authors.lastname: Ju
mesh_terms: D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D020732:Cytogenetic Analysis; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D014178:Translocation, Genetic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*
chemical_list: C113855:MLL-AF4 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein