title: Convenient three-dimensional cell culture in supermolecular hydrogels.
abstract: A convenient three-dimensional cell culture was developed by employing high swelling property of hybrid hydrogels coassembled from C2-phenyl-based supermolecular gelators and sodium hyaluronate. Imaging and spectroscopic analysis by scanning electron microscopy (SEM), atomic force microscopy (AFM), transform infrared (FT-IR) spectra confirm that the hybrid gelators can self-assemble into nanofibrous hydrogel. The high swelling property of dried gel ensures cell migration and proliferation inside bulk of the hydrogels, which provides a facial method to study disease models, the effect of drug dosages, and tissue culture in vitro.
authors.affiliation: State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiaotong University , 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Zongqi
authors.initials: Z
authors.lastname: Yin
authors.forename: Xiao-Qiu
authors.initials: XQ
authors.lastname: Dou
authors.forename: Guangdong
authors.initials: G
authors.lastname: Zhou
authors.forename: Chuan-Liang
authors.initials: CL
authors.lastname: Feng
mesh_terms: D018929:Cell Culture Techniques; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D020100:Hydrogels