title: [Renal complications after hematopoietic stem cell transplantation].
abstract: Hematopoietic stem cell transplantation is a widely used therapeutic modality for many, mainly malignant, diseases. Toxicities of this procedure include acute and chronic renal dysfunction. Acute renal failure, generally reversible is due to acute tubular necrosis (tumor lysis syndrome, marrow-infusion toxicity, sepsis, nephrotoxins), hepatic veno-occlusive disease or acute graft-versus-host disease. Chronic renal failure is often multifactorial, caused by conditioning-associated endothelial cell toxicity (bone marrow transplant nephropathy) and calcineurin inhibitors toxicity. Renal pathologic findings are somewhat similar to thrombotic microangiopathy, with sometimes systemic disease. Rare cases of nephrotic syndrome have been described after hematopoietic stem cell transplantation, mainly membranous nephropathy, associated with graft-versus-host disease. Therapeutic options for renal dysfunction after hematopoietic stem cell transplantation are limited but kidney transplantation is possible in case of end-stage renal disease.
authors.affiliation: Service de néphrologie et transplantation rénale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: imad.abboud@sls.aphp.fr.
authors.forename: Imad
authors.initials: I
authors.lastname: Abboud
authors.affiliation: Service de néphrologie et transplantation rénale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Évangeline
authors.initials: É
authors.lastname: Pillebout
authors.affiliation: Service d'anatomopathologie, hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Nochy
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*
keywords: Bone marrow transplantation; Calcineurin inhibitor; Greffe de cellules souches hématopoïétiques; Hematopoietic stem cell transplantation; Inhibiteur de la calcineurine; Insuffisance rénale aiguë; Insuffisance rénale chronique; Microangiopathie thrombotique; Renal dysfunction; Renal failure; Réaction du greffon contre l’hôte; Thrombotic microangiopathy