title: Eosinophilic esophagitis: interactions with gastroesophageal reflux disease.
abstract: Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are not mutually exclusive. The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. We believe that a clinical or histologic response to PPIs does not rule in GERD or rule out EoE. We recommend a trial of PPI therapy for patients with symptomatic esophageal eosinophilia, even if the diagnosis of EoE seems clear-cut.
authors.affiliation: Departments of Pediatrics and Internal Medicine, Esophageal Diseases Center, Children's Medical Center, VA North Texas Health Care System, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: edaire.cheng@utsouthwestern.edu.
authors.forename: Edaire
authors.initials: E
authors.lastname: Cheng
authors.affiliation: Department of Internal Medicine, Esophageal Diseases Center, Children's Medical Center, VA North Texas Health Care System, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Rhonda F
authors.initials: RF
authors.lastname: Souza
authors.affiliation: Department of Internal Medicine, Esophageal Diseases Center, Children's Medical Center, VA North Texas Health Care System, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Stuart Jon
authors.initials: SJ
authors.lastname: Spechler
mesh_terms: D057765:Eosinophilic Esophagitis / Q000150:complications* / Q000188:drug therapy; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors
keywords: Eosinophilic esophagitis; Gastroesophageal reflux disease; PPI-responsive esophageal eosinophilia; Proton pump inhibitors