title: Evaluation of nanodispersion of iron oxides using various polymers.
abstract: In order to create Fe2O3 and Fe2O3·H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe2O3 and Fe2O3·H2O particles. Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe2O3 nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill. Fe2O3·H2O nanoparticles could also be produced using 5.0% hydroxypropylcellulose-SSL and 4.0 and 7.0% Pharmacoat 904. The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ueyama
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ogata
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Daikoku
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Kotobuki Industries Co., Ltd., Ohashi-Gyoen-Bldg. 2F, 1-8-1 Shinjuku, Shinjuku-ku, Tokyo 1600022, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kitagawa
authors.affiliation: Kotobuki Industries Co., Ltd., Ohashi-Gyoen-Bldg. 2F, 1-8-1 Shinjuku, Shinjuku-ku, Tokyo 1600022, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Imajo
authors.affiliation: Kotobuki Industries Co., Ltd., Ohashi-Gyoen-Bldg. 2F, 1-8-1 Shinjuku, Shinjuku-ku, Tokyo 1600022, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tahara
authors.affiliation: Kotobuki Industries Co., Ltd., Ohashi-Gyoen-Bldg. 2F, 1-8-1 Shinjuku, Shinjuku-ku, Tokyo 1600022, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inkyo
authors.affiliation: Kishi Kasei Co., Ltd., 1-11-22 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 2360004, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamaguchi
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nagata
keywords: Dispersibility; iron oxide; nanoparticle; polymer; wet-milling