title: The molecular structure of Alzheimer β-amyloid fibrils formed in the presence of phospholipid vesicles.
abstract: β-amyloid (Aβ) fibrils are the major species involved in Alzheimer's disease (AD). An atomic-resolution molecular structure of Aβ40 fibrils formed in the presence of lipid vesicles was obtained by using magic angle spinning (MAS) solid-state NMR spectroscopy. The fibril structures formed in the presence of the lipid vesicles are remarkably different from those formed in solution. These results provide insights into the molecular mechanism of Aβ aggregation in the presence of lipid vesicles.
authors.affiliation: Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071 (P.R. China).
authors.forename: Zheng
authors.initials: Z
authors.lastname: Niu
authors.forename: Weijing
authors.initials: W
authors.lastname: Zhao
authors.forename: Zhengfeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Fanshu
authors.initials: F
authors.lastname: Xiao
authors.forename: Xinqi
authors.initials: X
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D010743:Phospholipids; C078592:amyloid beta-protein (1-40)
keywords: Alzheimer’s disease; NMR spectroscopy; magic-angle spinning; protein structures; β-amyloid aggregation