title: Case report and cohort analysis of drug-induced liver injury associated with daptomycin.
abstract: A patient receiving daptomycin developed asymptomatic transaminitis and hyperbilirubinemia without concurrent multiorgan dysfunction or elevation of his creatinine kinase level. After ruling out other etiologies, the liver injury was attributed to daptomycin and was subsequently resolved. A single-center retrospective cohort analysis of baseline and follow-up liver function panels (n = 614) from all admissions from 2008 to 2013 during which daptomycin was administered did not reveal any other cases of probable or definite drug-induced liver injury associated with daptomycin.
authors.affiliation: South Carolina College of Pharmacy, Charleston, South Carolina, USA bohm@musc.edu.
authors.forename: Nicole
authors.initials: N
authors.lastname: Bohm
authors.affiliation: Department of Pharmacy, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Makowski
authors.affiliation: South Carolina College of Pharmacy, Charleston, South Carolina, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Machado
authors.affiliation: College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Davie
authors.affiliation: College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Nelson
authors.initials: N
authors.lastname: Seabrook
authors.affiliation: College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: Wheless
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bevill
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Clark
authors.affiliation: Division of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: T Rogers
authors.initials: TR
authors.lastname: Kyle
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology / Q000534:rehabilitation; D017576:Daptomycin / Q000009:adverse effects*; D006760:Hospitalization; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000472:pathogenicity / Q000502:physiology; D020127:Recovery of Function; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin