title: Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment.
abstract: Nanoparticle-based therapeutics are poised to become a leading delivery strategy for cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer clearance times, and increased efficacy compared to conventional systemic therapeutic approaches. This article reviews existing nanoparticle technologies and methods that are used to target drugs to treat cancer by altering signal transduction or modulating the tumor microenvironment. We also consider the implications of recent advances in the nanotherapeutics field for the future of cancer therapy.
authors.affiliation: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
authors.forename: Mathumai
authors.initials: M
authors.lastname: Kanapathipillai
authors.affiliation: Department of Biomedical Engineering, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Brock
authors.affiliation: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. Electronic address: don.ingber@wyss.harvard.edu.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ingber
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents
keywords: Delivery; Drug; Microenvironment; Nanoparticle; Nanotherapeutics; Tumor