title: Inhibitory effects of edaravone in β-amyloid-induced neurotoxicity in rats.
abstract: Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis. Edaravone, a potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect in stroke patients. The current study aimed to investigate the effects of EDA in an Aβ-induced rat model of AD, by studying Aβ 1-40-induced voltage-gated calcium channel currents in hippocampal CA1 pyramidal neurons, learning and memory behavioral tests, the number of surviving cholinergic neurons in the basal forebrain, and the acetylcholine level in the hippocampus in this rat model of AD. The results showed that the Aβ 1-40-induced increase of I Ca can be inhibited by EDA in a dose-dependent manner. Treatment with EDA significantly improved Aβ 1-40-induced learning and memory performance. Choline acetyltransferase positive cells in basal forebrain and acetylcholine content in the hippocampus were increased by the administration of EDA as compared with the non-EDA treated Aβ 1-40 group. These results demonstrate that EDA can inhibit the neurotoxic effect of Aβ toxicity. Collectively, these findings suggest that EDA may serve as a potential complemental treatment strategy for AD.
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi City, Shandong 276000, China.
authors.forename: Feng
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Out-Patient, Yulin Teacher's College Hospital, Yulin, Guangxi 537000, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Cao
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi City, Shandong 276000, China.
authors.forename: Feng-Yuan
authors.initials: FY
authors.lastname: Che
authors.affiliation: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong 510120, China.
authors.forename: Lian-Hong
authors.initials: LH
authors.lastname: Yang
authors.affiliation: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong 510120, China.
authors.forename: Song-Hua
authors.initials: SH
authors.lastname: Xiao
authors.affiliation: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong 510120, China.
authors.forename: Jun
authors.identifier: 0000-0001-9202-5878
authors.initials: J
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D056547:CA1 Region, Hippocampal / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010446:Peptide Fragments / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016229:Amyloid beta-Peptides; D016166:Free Radical Scavengers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D000077553:Edaravone; D000983:Antipyrine