title: [Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
abstract: Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats. LHT 1-02 has proved to be more effective than the reference drugs vinpocetin and glycine in preventing the reperfusive damage, which was manifested by decreased postischemic hyperglycemia, activated utilization of oxygen in the brain, and suppressed postischemic metabolic lactate acidosis. Thus, the results of this comparative study show expediency of further investigations of LHT 1 - 02 as a potential neuroprotective drug.
authors.forename: L M
authors.initials: LM
authors.lastname: Makarova
authors.forename: M A
authors.initials: MA
authors.lastname: Prikhod'ko
authors.forename: V E
authors.initials: VE
authors.lastname: Pogorelyĭ
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Skachilova
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D000140:Acidosis, Lactic / Q000517:prevention & control; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002415:Cats; D018698:Glutamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology; D019344:Lactic Acid / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D014748:Vinca Alkaloids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D018696:Neuroprotective Agents; D014748:Vinca Alkaloids; C032858:apovincaminic acid; D019344:Lactic Acid; D018698:Glutamic Acid; C013983:vinpocetine; D005998:Glycine