title: Self-repair capability of surgically created incisions in TMJ disc: an experimental study on goats.
abstract: This study was to investigate whether surgically created incisions in discs at different sizes would heal spontaneously. Thirty mature goats were randomly divided into group A (1 mm), group B (3 mm) and group C (5 mm) according to the length of incision on the discs. Five animals in each group were sacrificed at 3 and 6 months postoperatively. The disc and condyle were evaluated by gross, histological and immunohistochemistry examinations. 1-mm discal incisions healed spontaneously with nearly normal gross and histological appearance at 6 months postoperatively, while 3-mm and 5-mm discal incisions failed to heal. Degenerative changes were observed in the fibrocartilage in both 3-mm and 5-mm incision groups, with a greater extent in the 5-mm group. Our results suggested that the TMJ disc of goat has limited self-repair capability to damage, which will be useful for making pre-surgical decisions related to the size and healing period of TMJ disc perforations.
authors.affiliation: The State Key Laboratory of Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of Cosmetic Surgery, The Third Hospital of Chengdu, Chengdu 610031, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.affiliation: The State Key Laboratory of Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Weina
authors.initials: W
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory of Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory of Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: The State Key Laboratory of Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: zss_1977@163.com.
authors.forename: Songsong
authors.initials: S
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D019902:Chondrocytes / Q000473:pathology; D024042:Collagen Type I / Q000032:analysis; D051445:Fibrocartilage / Q000473:pathology / Q000601:surgery; D006041:Goats; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology / Q000601:surgery; D023421:Models, Animal; D011897:Random Allocation; D019224:Temporomandibular Joint Disc / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology
chemical_list: D024042:Collagen Type I
keywords: Articular disc; Goat; Self-repair; Temporomandibular joint