title: Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults.
abstract: Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.
authors.affiliation: Division of Adolescent and Young Adult Health, Department of Pediatrics Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: S Todd
authors.initials: ST
authors.lastname: Callahan
authors.affiliation: EMMES Corp., Rockville, Maryland.
authors.forename: Mark
authors.initials: M
authors.lastname: Wolff
authors.affiliation: EMMES Corp., Rockville, Maryland.
authors.forename: Heather R
authors.initials: HR
authors.lastname: Hill
authors.affiliation: Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control* / Q000821:virology; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines
keywords: body mass index; immune response; influenza vaccine; obesity