title: The effect of propofol on intravenous glucose tolerance test in rhesus monkey.
abstract: BACKGROUND
  Many anesthetics have been shown to impair glucose metabolism and cause hyperglycemia. The aim of this study was to evaluate the effects of propofol on glucose metabolism and insulin secretion during intravenous glucose tolerance test (IVGTT) in rhesus monkey.
  
  
  METHODS
  Serum cortisol, blood glucose, insulin, and C-peptide concentrations during IVGTT were measured in four rhesus monkeys under either conscious state or propofol anesthesia.
  
  
  CONCLUSIONS
  The levels of serum cortisol significantly increased under conscious condition, whereas these levels remained constant under propofol anesthesia. In propofol group, the levels of serum insulin and C-peptide significantly increased compared with those in conscious group. Accordingly, glucose disposal capacity was significantly improved, and the time to return to basal glucose levels was shortened in propofol group. This study showed that propofol significantly increased insulin and C-peptide, and the corresponding improvement in glucose disposal may be related to reduction of serum cortisol in monkey.
authors.affiliation: Translational Xenotransplantation Research Center, Seoul, Korea; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; Medical Research Institute for Infectious Diseases, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Jun-Seop
authors.initials: JS
authors.lastname: Shin
authors.forename: Il Hee
authors.initials: IH
authors.lastname: Yoon
authors.forename: Byoung Hoon
authors.initials: BH
authors.lastname: Min
authors.forename: Won Young
authors.initials: WY
authors.lastname: Jeong
authors.forename: Ga Eul
authors.initials: GE
authors.lastname: Lee
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Ju Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Jae Yool
authors.initials: JY
authors.lastname: Jang
authors.forename: Chung-Gyu
authors.initials: CG
authors.lastname: Park
mesh_terms: D000758:Anesthesia; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002096:C-Peptide / Q000097:blood; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D015742:Propofol / Q000009:adverse effects*
chemical_list: D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D006854:Hydrocortisone; D015742:Propofol
keywords: cortisol; insulin secretion; intravenous glucose tolerance test; propofol; rhesus monkey