title: Incidence of cancer following bariatric surgery: systematic review and meta-analysis.
abstract: Obesity is linked to the development of cancer. Previous studies have suggested that there is a relationship between bariatric surgery and reduced cancer risk. Data sources were from Medline, Embase, and Cochrane Library. From 951 references, 13 studies met the inclusion criteria (54,257 participants). In controlled studies, bariatric surgery was associated with a reduction in the risk of cancer. The cancer incidence density rate was 1.06 cases per 1000 person-years within the surgery groups. In the meta-regression, we found an inverse relationship between the presurgical body mass index and cancer incidence after surgery (beta coefficient -0.2, P < 0.05). Bariatric surgery is associated with reduced cancer risk in morbidly obese people. However, considering the heterogeneity among the studies, conclusions should be drawn with care.
authors.affiliation: Postgraduate Program in Medical Sciences: Endocrinology and Metabolism, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, 90035-003, Porto Alegre, RS, Brazil.
authors.forename: Daniela Schaan
authors.initials: DS
authors.lastname: Casagrande
authors.forename: Daniela Dornelles
authors.initials: DD
authors.lastname: Rosa
authors.forename: Daniel
authors.initials: D
authors.lastname: Umpierre
authors.forename: Roberta Aguiar
authors.initials: RA
authors.lastname: Sarmento
authors.forename: Clarissa Garcia
authors.initials: CG
authors.lastname: Rodrigues
authors.forename: Beatriz D
authors.initials: BD
authors.lastname: Schaan
mesh_terms: D050110:Bariatric Surgery; D015992:Body Mass Index; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology*; D009767:Obesity, Morbid / Q000453:epidemiology / Q000601:surgery*; D065840:Protective Factors; D015431:Weight Loss