title: Technical development of a new semispherical radiofrequency bipolar device (RONJA): ex vivo and in vivo studies.
abstract: The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation of healthy tissue, numerous needle punctures, and, therefore, longer operating procedure. Our newly designed and tested semispherical surgical tool can solve some of these disadvantages. By conducting an in vivo study on a set of 12 pigs, randomly divided into two groups, we have compared efficiency of the newly developed instrument with the commonly used device. Statistical analysis showed that there were no significant differences between the groups. On average, the tested instrument RONJA had shorter ablation time in both liver lobes and reduced the total operating time. The depth of the thermal alteration was on average 4 mm larger using the newly tested instrument. The new radiofrequency method described in this study could be used in open liver surgery for the treatment of small liver malignancies (up to 2 cm) in a single application with the aim of saving healthy liver parenchyma. Further experimental studies are needed to confirm these results before clinical application of the method in the treatment of human liver malignancies.
authors.affiliation: Department of Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic ; Department of Cybernetics and Biomedical Engineering, Faculty of Electrical Engineering and Computer Science, VSB-Technical University of Ostrava, 17. listopadu 15, 708 00 Ostrava-Poruba, Czech Republic ; Department of Surgery, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava 3, Czech Republic ; Liver and Pancreas Surgery, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0HS, UK.
authors.forename: Petr
authors.initials: P
authors.lastname: Vavra
authors.affiliation: Department of Cybernetics and Biomedical Engineering, Faculty of Electrical Engineering and Computer Science, VSB-Technical University of Ostrava, 17. listopadu 15, 708 00 Ostrava-Poruba, Czech Republic.
authors.forename: Marek
authors.identifier: 0000-0001-9527-4642
authors.initials: M
authors.lastname: Penhaker
authors.affiliation: Faculty of Mechanical Engineering, VSB-Technical University of Ostrava, 17. listopadu 15, 708 00 Ostrava-Poruba, Czech Republic.
authors.forename: Jan
authors.identifier: 0000-0001-9991-482X
authors.initials: J
authors.lastname: Grepl
authors.affiliation: Department of Vice-President for Science and Research, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Jurcikova
authors.affiliation: Department of Surgery, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava 3, Czech Republic.
authors.forename: Jiri
authors.identifier: 0000-0003-3614-8528
authors.initials: J
authors.lastname: Palecek
authors.affiliation: CEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1/3, 612 42 Brno-Královo Pole, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Crha
authors.affiliation: Department of Cybernetics and Biomedical Engineering, Faculty of Electrical Engineering and Computer Science, VSB-Technical University of Ostrava, 17. listopadu 15, 708 00 Ostrava-Poruba, Czech Republic.
authors.forename: Jana
authors.identifier: 0000-0002-5213-3302
authors.initials: J
authors.lastname: Nowakova
authors.affiliation: Department of Cybernetics and Biomedical Engineering, Faculty of Electrical Engineering and Computer Science, VSB-Technical University of Ostrava, 17. listopadu 15, 708 00 Ostrava-Poruba, Czech Republic.
authors.forename: Martin
authors.identifier: 0000-0001-7073-9642
authors.initials: M
authors.lastname: Hasal
authors.affiliation: Department of Surgery, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava 3, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Skrobankova
authors.affiliation: Department of Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Ostruszka
authors.affiliation: Department of Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic ; Department of Surgery, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava 3, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Ihnat
authors.affiliation: Institute of Pathology, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic ; Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava 3, Czech Republic.
authors.forename: Patricie
authors.initials: P
authors.lastname: Delongova
authors.affiliation: Department of Mathematical Methods in Economy, Faculty of Economics, VSB-Technical University of Ostrava, 17. listopadu 15, 708 00 Ostrava-Poruba, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Salounova
authors.affiliation: Liver and Pancreas Surgery, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0HS, UK.
authors.forename: Nagy A
authors.initials: NA
authors.lastname: Habib
authors.affiliation: Department of Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic ; Department of Surgery, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava 3, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Zonca
mesh_terms: D000818:Animals; D001706:Biopsy; D017115:Catheter Ablation / Q000295:instrumentation*; D004566:Electrodes; D066298:In Vitro Techniques; D008099:Liver / Q000473:pathology / Q000601:surgery*; D034421:Sus scrofa; D013817:Thermography