title: [Nephrotic syndrome in a woman with tuberous sclerosis].
abstract: METHODS
  A 50-year-old woman with known tuberous sclerosis complex (TSC) was referred for further work-up of nephrotic syndrome. A left-side nephrectomy due to an anamnestically reported "shrunken kidney" had been performed at the age of 15 years. The patient presented with massive edematous swelling of all extremities and typical cutaneous lesions of TSC. DIAGNOSTIC FINDINGS, TREATMENT AND CLINICAL COURSE: Laboratory analysis revealed nephrotic proteinuria, hypalbuminemia and advanced impairment of kidney function. Computed tomography revealed a massively enlarged remaining kidney with confluent angiomyolipomata. As kidney biopsy was deemed to be too hazardous, a thorough work-up for potentially underlying diseases finally revealed endometrial carcinoma. Hysterectomy resulted in a prompt and sustained decrease of proteinuria and disappearance of edema.
  
  
  CONCLUSIONS
  Although a renal involvement is typical in TSC the occurrence of nephrotic syndrome is not and should give reason for further evaluation.
authors.affiliation: Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Sauter
authors.affiliation: Institut für klinische Radiologie, Klinikum der Universität München.
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.affiliation: Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Fischereder
mesh_terms: D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis* / Q000601:surgery*; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000175:diagnosis* / Q000601:surgery*