title: Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides.
abstract: Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H2S(n), n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H2S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H2S(n) is rapidly growing. However, the detection of H2S(n) is still challenging. In this work we report a H2S(n)-mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H2S(n) are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H2S(n).
authors.affiliation: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Shi
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Huimin
authors.initials: H
authors.lastname: Ma
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D006862:Hydrogen Sulfide / Q000032:analysis*; D015394:Molecular Structure; D013440:Sulfides / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D013440:Sulfides; C032915:polysulfide; D006862:Hydrogen Sulfide