title: Preventing intraperitoneal adhesions with linezolid and hyaluronic acid/carboxymethylcellulose: a comparative study in cecal abrasion model.
abstract: BACKGROUND
  We aimed to compare the effectiveness of linezolid in preventing intraperitoneal adhesions with hyaluronic acid + carboxymethylcellulose (Seprafilm).
  
  
  METHODS
  Thirty rats were divided randomly into 3 groups: Group I (control), untreated; Group II (Seprafilm); and Group III (linezolid). All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, inflammation, and fibrosis were evaluated.
  
  
  RESULTS
  The multiple comparisons between groups showed a statistically significant difference for adhesion. There were statistically significant differences between Group I and II and I and III, but no statistically significant difference between Group II and III. The multiple comparisons between the groups showed a statistically significant difference for inflammation and fibrosis. For inflammation and fibrosis, there was a statistically significant difference between Group I and II and I and III, but no statistically significant difference between Group II and III.
  
  
  CONCLUSIONS
  The efficiency of linezolid in reducing the formation of intraperitoneal adhesions was statistically significant compared with the control group.
authors.affiliation: Faculty of Medicine, Department of Surgery, Bozok University, Yozgat, Turkey. Electronic address: kasimcaglayan@hotmail.com.
authors.forename: Kasim
authors.initials: K
authors.lastname: Caglayan
authors.affiliation: Faculty of Medicine, Department of Surgery, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Gungor
authors.affiliation: Department of Surgery, Siirt Kurtalan State Hospital, Siirt, Turkey.
authors.forename: Hamza
authors.initials: H
authors.lastname: Cinar
authors.affiliation: Department of Pathology, Taksim Training and Education Hospital, Istanbul, Turkey.
authors.forename: Nilsen Y
authors.initials: NY
authors.lastname: Erdogan
authors.affiliation: Faculty of Medicine, Department of Surgery, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Koca
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D002432:Cecum / Q000601:surgery; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D000069349:Linezolid; D023303:Oxazolidinones / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D023303:Oxazolidinones; C118198:Seprafilm; D006820:Hyaluronic Acid; D000069349:Linezolid; D002266:Carboxymethylcellulose Sodium
keywords: Hyaluronic acid + carboxymethylcellulose; Intraperitoneal adhesion; Linezolid