title: Does gestational diabetes mellitus affect respiratory outcome in late-preterm infants?
abstract: BACKGROUND
  Both gestational diabetes mellitus (GDM) and late-preterm delivery at 34-36 weeks' gestation are independently associated with neonatal respiratory complications, but it is unknown whether their combination increases further its risk. We therefore appraised the independent effect of GDM on the respiratory outcome of late-preterm infants.
  
  
  METHODS
  In a retrospective cohort study, respiratory outcome of 911 infants delivered at 34-36 weeks' gestation between 1 January 2009 and 30 August 2012 from mothers with GDM (study group, n=130) was compared with infants delivered at the same gestation by mothers without GDM (control group, n=781).
  
  
  RESULTS
  The study group had significantly higher incidence of transient tachypnoea of newborn (TTN, p=0.02) and air leak (p=0.012), and required more respiratory support, including oxygen, continuous positive airway pressure (CPAP), mechanical ventilation and neonatal intensive care, with a longer length of hospital stay, but not duration on respiratory support. On logistic regression analysis, GDM is an independent risk factor for TTN (aOR=1.5, 95% C.I.1.0-2.4), CPAP (aOR=2.37, 95% C.I. 1.05-4.89), mechanical ventilation (aOR=4.02 95% C.I. 1.57-10.32) and neonatal intensive care (aOR 1.83, 95% C.I. 1.05-3.87).
  
  
  CONCLUSIONS
  Our results demonstrated an independent effect of GDM on the risk of severe respiratory complications in late-preterm infants. Additional close monitoring and timely intervention are necessary in the management of these infants.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong. Electronic address: fungpg@hotmail.com.
authors.forename: G P G
authors.initials: GP
authors.lastname: Fung
authors.affiliation: Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong.
authors.forename: L M
authors.initials: LM
authors.lastname: Chan
authors.affiliation: Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong.
authors.forename: Y C
authors.initials: YC
authors.lastname: Ho
authors.affiliation: Department of Obstetrics and Gynaecology, United Christian Hospital, Hong Kong.
authors.forename: W K
authors.initials: WK
authors.lastname: To
authors.affiliation: Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong.
authors.forename: H B
authors.initials: HB
authors.lastname: Chan
authors.affiliation: Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Hong Kong.
authors.forename: T T
authors.initials: TT
authors.lastname: Lao
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007902:Length of Stay; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy; D012119:Respiration; D012189:Retrospective Studies
keywords: Chinese; Diabetes mellitus; Late preterm; Neonatal outcome; Preterm infant; Respiratory distress