title: Wound healing in acutely injured fascia.
abstract: Fascial healing following acute injury, such as that occurring during surgical procedures, is defined functionally. For example, failure of fascial healing following celiotomy is only identified when incisional hernias are diagnosed. Such hernias incur billions of dollars per year in medical costs. Despite the importance of fascial healing, there is a paucity of data regarding the quality such healing. In clinical settings, the quantification of fascial wound healing is limited to a binary state: either there is no clinically apparent functional deficit and full fascia healing is assumed, or an incisional hernia or other functional failure is visible and the fascia did not heal. There are no clinical methods to isolate and functionally test fascia in patients. Recent studies have revealed unexpected findings regarding the recovery of tensile strength, specific surgical methods that optimize fascial healing, and the potential impact of biological pharmaceuticals in eliminating fascial healing failure. However, much remains unknown about the biology of fascial healing.
authors.affiliation: Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Frank H
authors.initials: FH
authors.lastname: Lau
authors.forename: Bohdan
authors.initials: B
authors.lastname: Pomahac
mesh_terms: D000009:Abdominal Muscles / Q000473:pathology* / Q000601:surgery; D005205:Fascia / Q000473:pathology*; D000071938:Fasciotomy; D006801:Humans; D007150:Immunohistochemistry; D011183:Postoperative Complications / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013529:Surgical Wound Dehiscence / Q000473:pathology; D013718:Tensile Strength; D014945:Wound Healing