title: [Prognostic value of IL-10 expression in tumor tissues of breast cancer patients].
abstract: OBJECTIVE
  To evaluate the prognostic value of IL-10 expression in breast cancer patients and determine the correlation between IL-10 expression and clinicopathological features of breast cancer.
  
  
  METHODS
  Paraffin sections were retrospectively collected from 130 patients of stage I-III breast cancer who received surgery between January 2000 and December 2002 in the Chinese PLA General Hospital. The protein expression of IL-10 in the primary lesions was detected by immunohistochemistry to analyze the correlations of IL-10 expression with clinicopathological variables and prognosis.
  
  
  RESULTS
  IL-10 was found expressed in the cytoplasm of both tumor cells and stromal cells. Higher IL-10 expression in tumor cell cytoplasm was associated with lower T grade (P=0.012), higher SBR grade (P=0.004), positive ER (P=0.007), negative vascular invasion (P=0.034). The multivariant COX regression analysis showed that higher IL-10 expression in tumor cell cytoplasm was associated with better disease-free survival (HR=0.443, P=0.022) and that higher density of IL-10⁺; in stromal cell cytoplasm was associated with overall survival (HR=0.411, P=0.051).
  
  
  CONCLUSIONS
  IL-10 expression level in breast tumor cells and stromal cells can be used as a predictor of breast cancer prognosis. Low expression of IL-10 is associated with poor survival outcome.
authors.affiliation: Department of Medical Oncology, PLA General Hospital, Beijing 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, PLA General Hospital, Beijing 100853, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Medical Oncology, PLA General Hospital, Beijing 100853, China.
authors.forename: Shunchang
authors.initials: S
authors.lastname: Jiao
authors.affiliation: Department of Medical Oncology, PLA General Hospital, Beijing 100853, China.
authors.forename: Junlan
authors.initials: J
authors.lastname: Yang
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003593:Cytoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000096:biosynthesis*; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: D016753:Interleukin-10