title: The use of glyburide in the management of gestational diabetes mellitus: a meta-analysis.
abstract: OBJECTIVE
  Glyburide has been used for managing gestational diabetes mellitus (GDM) in a number of countries. It is rather inexpensive. However, its efficacy and safety remain controversial. With this meta-analysis, we evaluated glyburide in comparison with insulin.
  
  
  METHODS
  With a systematic literature search strategy, a total of 93 randomized controlled trials (RCTs) with insulin and glyburide comparison were identified. Based on the revised Consolidated Standards of Reporting Trials (CONSORT) checklist, five of them met the inclusion criteria and were included in this meta-analysis.
  
  
  RESULTS
  Six hundred and seventy four subjects were included in these five RCTs. When compared with insulin, glyburide had an increased relative risk (RR) for neonatal hypoglycemia (RR: 1.98; 95% confidence interval [CI]: 1.17, 3.36). Estimation of standard mean differences (SMD) showed that both fetal birth weight and incidence of macrosomia were higher in subjects receiving glyburide than in those receiving insulin (SMD: 0.21; 95% CI: 0.06, 0.36; RR: 2.22; 95% CI: 1.07, 4.61 respectively). There were no significant differences in maternal glucose control, glycated hemoglobin, the rate of Cesarean section, large-for-gestational age, neonatal hypocalcemia, length of stay for neonatal ICU admissions, preterm birth, or congenital anomalies.
  
  
  CONCLUSIONS
  Our study suggested that in women with GDM, glyburide is as effective as insulin, but the risks of neonatal hypoglycemia, high fetal birth weight, and macrosomia were higher.
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang Xi, PR China.
authors.forename: Ya-chang
authors.initials: YC
authors.lastname: Zeng
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang Xi, PR China. Electronic address: lmj1699@vip.163.com.
authors.forename: Mu-jun
authors.initials: MJ
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang Xi, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang Xi, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang Xi, PR China.
authors.forename: Su-mei
authors.initials: SM
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guang Xi, PR China.
authors.forename: Xiao-liang
authors.initials: XL
authors.lastname: Mo
authors.affiliation: Department of Ophthalmology, Nanning Red-Cross Hospital, Nanning, Guang Xi, PR China.
authors.forename: Bin-Yi
authors.initials: BY
authors.lastname: Li
mesh_terms: D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005905:Glyburide
keywords: Gestational diabetes mellitus; Glyburide; Insulin; Meta-analysis