title: [Hypertension].
abstract: Hypertension is well known to one of the risk factors to reduce cognitive function, however, it is still unclear whether anti-hypertensive therapy is effective to prevent development of dementia or Alzheimer's disease. Epidemiological studies suggested antihypertensive therapy from the middle-age could reduce risk of dementia. The meta-analysis including HYVET also suggested blood pressure lowering from the elderly might be also effective to prevent development of dementia. The network meta-analysis and the cohort study using mega-data bank suggested ARB might be effective to prevent development of dementia or Alzheimer's disease compared to administration with other anti-hypertensive drugs. Although the further major clinical investigation is required, anti-hypertensive treatment might be useful to manage hypertensive patients with dementia.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ohishi
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D003704:Dementia / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000628:therapy*
chemical_list: D000959:Antihypertensive Agents