title: Matricryptins and matrikines: biologically active fragments of the extracellular matrix.
abstract: Numerous extracellular proteins and glycosaminoglycans (GAGs) undergo limited enzymatic cleavage resulting in the release of fragments exerting biological activities, which are usually different from those of the full-length molecules. In this review, we define matrikines and matricryptins, which are bioactive fragments released from the extracellular matrix proteins, proteoglycans and GAGs and report their major biological activities. These fragments regulate a number of physiopathological processes including angiogenesis, cancer, fibrosis, inflammation, neurodegenerative diseases and wound healing. The challenges to translate these fragments from molecules biologically active in vitro and in experimental models to potential drugs are discussed in the last part of the review.
authors.affiliation: Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS, Université Lyon 1, Lyon Cedex 07, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ricard-Blum
authors.forename: Romain
authors.initials: R
authors.lastname: Salza
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism / Q000502:physiology*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D051379:Mice; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism; D009389:Neovascularization, Pathologic; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D017434:Protein Structure, Tertiary; D011509:Proteoglycans / Q000378:metabolism*; D040901:Proteomics; D012871:Skin Diseases / Q000378:metabolism; D049490:Systems Biology; D014945:Wound Healing / Q000502:physiology
chemical_list: D016326:Extracellular Matrix Proteins; D006025:Glycosaminoglycans; D011509:Proteoglycans
keywords: bioactive fragments; endostatin; extracellular matrix; matricryptins; matrikines