title: Anti-Müllerian hormone in reproductive age women with systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune systemic and chronic disease. Fertility in SLE patients is considered normal; factors that have been associated in these patients with ovarian failure are: disease activity, autoantibodies, and the use of cytotoxic agents. The anti-Müllerian hormone (AMH) is a marker that helps to determine the follicular reserve.
  
  
  OBJECTIVE
  Determinate the objective was to determine AMH levels in women of reproductive age with SLE.
  
  
  METHODS
  We included 65 women with SLE classified according to the 1997 ACR criteria, 18- to 40-years old. We obtained demographic, clinical, obstetric, and gynecological characteristics as well as serum levels of AMH. We performed a bivariate analysis among patients with low ovarian reserve and those with normal ovarian reserve. We also performed a correlation analysis between activity and damage index and between the cumulative cyclophosphamide dose and AMH levels.
  
  
  RESULTS
  We found a median of serum AMH in SLE patients of .61 ng/mL. The prevalence of low ovarian reserve in our study was 3.07%. We found a median MEX-SLEDAI score of 1 point and the median SLICC score was 2 points. Twenty-five patients (38.4%) had used cyclophosphamide and their cumulative average dose was 7.5 grams.
  
  
  CONCLUSIONS
  We found a median of AMH of .61 ng/mL in our population. The prevalence of low ovarian reserve in SLE patients was 3.07%. We did not find a correlation between AMH levels, the use of cyclophosphamide, and disease activity.
authors.affiliation: Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Velarde-Ochoa
authors.affiliation: Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Jorge Antonio
authors.initials: JA
authors.lastname: Esquivel-Valerio
authors.affiliation: Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México. Electronic address: drdavidvega@yahoo.com.mx.
authors.forename: David
authors.initials: D
authors.lastname: Vega-Morales
authors.affiliation: Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Cassandra Michele
authors.initials: CM
authors.lastname: Skinner-Taylor
authors.affiliation: Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Dionicio Ángel
authors.initials: DÁ
authors.lastname: Galarza-Delgado
authors.affiliation: Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Mario Alberto
authors.initials: MA
authors.lastname: Garza-Elizondo
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000503:physiopathology; D065851:Ovarian Reserve; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: Anti-müllerian hormone; Ciclofosfamida; Cyclophosphamide; Hispanic americans; Hormona anti-mülleriana; Latinoamericanos; Lupus eritematoso sistémico; Systemic lupus erythematosus