title: Adult neurogenesis: mechanisms and functional significance.
abstract: New neurons are generated throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, has been implicated in physiological brain function, and failing or altered neurogenesis has been associated with a number of neuropsychiatric diseases. Here, we provide an overview of the mechanisms governing the neurogenic process in the adult brain and describe how new neurons may contribute to brain function in health and disease.
authors.affiliation: Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: Simon M G
authors.initials: SM
authors.lastname: Braun
authors.forename: Sebastian
authors.initials: S
authors.lastname: Jessberger
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D055153:Stem Cell Niche / Q000502:physiology
keywords: Neural stem cell; Neurogenesis; Neurons; Neuropsychiatric disease