title: Spontaneous biomimetic formation of (±)-dictazole B under irradiation with artificial sunlight.
abstract: Guided by biosynthetic considerations, the total synthesis of dictazole B is reported for the first time. Experimental evidence for an easy access to challenging cyclobutane alkaloids of marine origin, which are often postulated to be biosynthetic precursors of more complex structures, is provided.
authors.affiliation: Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 BioCIS, LabEx LERMIT, Université Paris-Sud, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry (France) http://www.biocis.u-psud.fr.
authors.forename: Adam
authors.initials: A
authors.lastname: Skiredj
authors.forename: Mehdi A
authors.initials: MA
authors.lastname: Beniddir
authors.forename: Delphine
authors.initials: D
authors.lastname: Joseph
authors.forename: Karine
authors.initials: K
authors.lastname: Leblanc
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bernadat
authors.forename: Laurent
authors.initials: L
authors.lastname: Evanno
authors.forename: Erwan
authors.initials: E
authors.lastname: Poupon
mesh_terms: D032701:Biomimetics; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013472:Sunlight
chemical_list: D003503:Cyclobutanes; D026121:Indole Alkaloids; C550133:dictazole B
keywords: alkaloids; aplysinopsin; biomimetic synthesis; natural products; self-assembly