title: C-terminal AKT phosphorylation by CDK2-cyclin A or mTOR activates AKT.
abstract: CDK2-cyclin A2 or mTOR activate AKT via phosphorylation of the C-terminal residues S477 and T479.
mesh_terms: D019943:Amino Acid Substitution; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D056751:Cyclin A2 / Q000378:metabolism*; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism; D005260:Female; D006801:Humans; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: C503721:CCNA2 protein, human; D056751:Cyclin A2; C546842:MTOR protein, human; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2