title: The fire within: microbes inflame tumors.
abstract: The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment.
authors.affiliation: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
authors.forename: Nicola
authors.initials: N
authors.lastname: Gagliani
authors.affiliation: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, Hamburg, Germany.
authors.forename: Samuel
authors.initials: S
authors.lastname: Huber
authors.affiliation: Immunology Department, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
authors.affiliation: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, School of Medicine, Yale University, New Haven, CT 06520, USA. Electronic address: richard.flavell@yale.edu.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D005759:Gastroenteritis / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D007113:Immunity, Innate; D007414:Intestinal Neoplasms / Q000276:immunology* / Q000382:microbiology*; D064307:Microbiota; D058504:Th17 Cells / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D051193:Toll-Like Receptors