title: Breast carcinoma with osteoclastic giant cells: case report and review of the literature.
abstract: Breast carcinoma with osteoclastic giant cells (OGCs) are uncommon. Here, we report a 46-year-old woman with a painless lump in her left breast that has been proved clinically and radiographically. Microscopical examination showed OGCs accompanying invasive ductal carcinoma. Immunohistochemical assay revealed that OGCs derived from macrophages. Despite positive lymph node metastasis, the patient has been well without evidence of recurrence or metastasis one year after the operation. To date, the influence of OGCs on the prognosis of patients is still controversial. Our case may provide insights into further understanding beast carcinoma with OGCs.
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Imaging Center, Nanfang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Xuenong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China ; Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008327:Mammography; D008408:Mastectomy; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology*; D016896:Treatment Outcome
keywords: Breast carcinoma; immunohistochemistry; osteoclastic giant cells; prognosis; tumor metastasis