title: Signaling Pathways and Epigenetic Regulations in the Control of RORγt Expression in T Helper 17 Cells.
abstract: T helper 17 (Th17) cells constitute a unique T-cell lineage that plays a crucial role in inflammatory diseases. A decade ago, retinoic acid receptor-related orphan receptor-γt (RORγt) was identified as the specific transcription factor required for Th17-cell lineage commitment. However, the underlying mechanisms involved in the regulation of the RORγt expression remain largely unclear and therefore preclude the accurate identification and manipulation of Th17 cells. In this review, we summarize the recent advances to obtain an understanding of how RORγt expression is controlled at the molecular level, highlighting the importance of signal transduction pathways and epigenetic regulations in the control of RORγt expression in Th17 cells.
authors.affiliation: Institute of Immunology, PLA, Third Military Medical University , Chongqing , P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tian
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Ni
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3
keywords: RORγt gene; Th17 cells; epigenetic; signaling pathway; transcriptional regulation