title: Soluble Lectin-Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome.
abstract: BACKGROUND
  Metabolic syndrome (MetS) defines a well-known cluster of metabolic disturbances associated with an increased risk of cardiovascular disease and diabetes. The aim of this study was to examine the distribution of soluble lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (sLOX-1) levels in patients with MetS, possible association of sLOX-1 with oxidized LDL (oxLDL), endothelial nitric oxide synthase (eNOS), nitric oxide (NOx), endothelin-1 (ET-1), paraoxonase 1 (PON1), and arylesterase (ARE) activities, and these parameters compared with healthy controls.
  
  
  METHODS
  A total of 55 patients (37 women, 18 men) with MetS and 29 healthy controls (19 women, 10 men) with a body mass index (BMI) less than 25 kg/m(2) were enrolled in the study.
  
  
  RESULTS
  sLOX-1, oxLDL, and ET-1 levels were significantly higher in patients with MetS than in control subjects (P = 0.023 P < 0.001, and P < 0.001, respectively). MetS patients have significantly lower eNOS and NOx levels, and PON1 and ARE activities than control subjects (P = 0.017, P < 0.004, P < 0.001, and P = 0.010, respectively). A positive correlation was observed between the sLOX-1 levels and the oxLDL, ET-1, BMI, glucose levels. ET-1 levels also exhibited significant negative correlation with ARE activity.
  
  
  CONCLUSIONS
  sLOX-1 levels are associated with cardiovascular risk factors, such as increased oxLDL, obesity, and diabetes, in patients with MetS. An increased concentration of sLOX-1 could be an early predictor of endothelial damage in MetS. In addition, it appears that oxLDL, ET-1, eNOS, NOx, PON1, and ARE activities may accurately reflect the levels of endothelial dysfunction in MetS patients.
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Civelek
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kutnu
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Uzun
authors.affiliation: Istanbul Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Erdenen
authors.affiliation: Istanbul Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Altunoglu
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Andican
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Seven
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: A O
authors.initials: AO
authors.lastname: Sahin
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Burcak
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood; D015992:Body Mass Index; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D008659:Metabolic Diseases / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D052250:Nitric Oxide Synthase Type III / Q000097:blood; D012372:ROC Curve; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: D019332:Endothelin-1; D008077:Lipoproteins, LDL; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: endothelial nitric oxide synthase; endothelin-1; metabolic syndrome; nitric oxide; oxidized LDL; soluble lectin-like oxidized LDL receptor 1