title: Cognitive and motor perturbations in elderly with longstanding diabetes mellitus.
abstract: Type 2 diabetes mellitus is a chronic disease characterized by insulin resistance; inflammation; oxidative stress; vascular damage; and dysfunction of glucose, protein, and lipid metabolisms. However, comparatively less attention has been paid to neurologic alterations seen in elderly individuals with type 2 diabetes. We review clinical, metabolic, and biochemical aspects of diabetic encephalopathy (DE) and propose that quality of dietary lipids is closely linked to DE. This implies that preventive nutritional interventions may be designed to improve DE.
authors.affiliation: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
authors.forename: G T
authors.initials: GT
authors.lastname: Díaz-Gerevini
authors.affiliation: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; Cátedra de Histología, Embriología y Genética, Universidad Nacional de La Rioja, La Rioja, Argentina; CONICET, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Repossi
authors.affiliation: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Dain
authors.affiliation: CONICET, Argentina; Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Tarres
authors.affiliation: Department of Medicine, GVP Hospital and BioScience Research Centre, Campus of Gayatri Vidya Parishad College of Engineering, Visakhapatnam, India; UND Life Sciences, Federal Way, Washington, USA.
authors.forename: U N
authors.initials: UN
authors.lastname: Das
authors.affiliation: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; CONICET, Argentina. Electronic address: Aeynard@gmail.com.
authors.forename: A R
authors.initials: AR
authors.lastname: Eynard
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003071:Cognition; D003072:Cognition Disorders / Q000178:diet therapy / Q000209:etiology / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D007328:Insulin / Q000378:metabolism; D014652:Vascular Diseases / Q000178:diet therapy / Q000209:etiology / Q000503:physiopathology
chemical_list: D007328:Insulin
keywords: DE (Diabetic Encephalopathy); Diabetes mellitus; Dietary lipids; Insulin resistance; Oxidative stress