title: Curcumin, a component of golden spice: from bedside to bench and back.
abstract: Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of years, it is only within the past century that we learned about the chemistry of its active component, curcumin. More than 6000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical. Over sixty five clinical trials conducted on this molecules, have shed light on the role of curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer. The current review provides an overview of the history, chemistry, analogs, and mechanism of action of curcumin.
authors.affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Sahdeo
authors.initials: S
authors.lastname: Prasad
authors.affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Subash C
authors.initials: SC
authors.lastname: Gupta
authors.affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Tyagi
authors.affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: aggarwal@mdanderson.org.
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Aggarwal
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D002460:Cell Line; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin; D006801:Humans; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D017365:Spices
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D003474:Curcumin
keywords: Chronic diseases; Clinical trials; Curcumin; Curcumin analogs; Inflammation