title: Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam.
abstract: We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.
authors.affiliation: a Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110 001 , India.
authors.forename: Jaggaiah N
authors.initials: JN
authors.lastname: Gorantla
authors.forename: Jamsheena
authors.initials: J
authors.lastname: Vellekkatt
authors.forename: Lekshmi R
authors.initials: LR
authors.lastname: Nath
authors.forename: Ruby John
authors.initials: RJ
authors.lastname: Anto
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Lankalapalli
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D007194:India; D020128:Inhibitory Concentration 50; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D014197:Trees / Q000737:chemistry*
chemical_list: D057889:Iridoid Glycosides; C000593912:theveside; C000593911:theviridoside
keywords: Cerbera odollam; cytotoxicity; semi-synthetic derivatives; theveside; theviridoside