title: Cross-electrophile coupling: principles of reactivity and selectivity.
abstract: A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this challenge: (1) employing an excess of one reagent; (2) electronic differentiation of starting materials; (3) catalyst-substrate steric matching; and (4) radical chain processes. Each method is described using examples from the recent literature.
authors.affiliation: Department of Chemistry, University of Rochester , Rochester, New York 14627-0216, United States.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Everson
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weix
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D001593:Benzyl Compounds; D003432:Cross-Linking Reagents; D007202:Indicators and Reagents