title: Urinary excretion of liver-type FABP as a new clinical marker for the progression of obstructive nephropathy.
abstract: OBJECTIVE
  The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON).
  
  
  METHODS
  A total of 108 ON patients and urine samples were collected. An ELISA was used to determine the uL-FABP and uNGAL levels. A total of 90 patients completed the 1-year follow-up and were used to evaluate the predictive value of uL-FABP and uNGAL for the renal prognosis in ON.
  
  
  RESULTS
  During the 1-year renal function follow-up, the uL-FABP level was significantly correlated with poor prognosis. When the preoperative uL-FABP and uNGAL or 72-h postoperative uL-FABP and uNGAL levels were combined, the areas under the curve for renal prognosis were 0.968 and 0.952, respectively.
  
  
  CONCLUSIONS
  uL-FABP was helpful for the prediction of renal prognosis in ON. The combination of uL-FABP and uNGAL increased the accuracy of prediction.
authors.affiliation: Department of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai, 200127, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xie
authors.forename: Weijia
authors.initials: W
authors.lastname: Xu
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Xinghua
authors.initials: X
authors.lastname: Shao
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ni
authors.forename: Shan
authors.initials: S
authors.lastname: Mou
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000209:Acute-Phase Proteins / Q000652:urine; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000652:urine; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine