title: Managing hypertension in the newborn infants.
abstract: Hypertension in newborn infants, particularly those requiring intensive care, is becoming increasingly recognized, with prevalence of 0.2-3%. Recent studies have established normative tables for blood pressure (BP) in both term and pre-term infants based on the gestational age, postnatal age, gender, weight and height, identifying the neonates at increased risk for early-onset cardiovascular disease. Common causes of neonatal hypertension include thromboembolic complications secondary to umbilical artery catheterization, congenital renal structural malformation, renovascular disease, aortic coarctation, as well as acute kidney injury and certain medications. A careful diagnostic evaluation should lead to identification of the underlying cause of hypertension in most infants. Treatment options should be tailored to the severity; and underlying cause of hypertension, including intravenous and/or oral therapy. This review summarizes recent work in these areas, focusing on optimal BP measurement, definition, evaluation and management of hypertension as well as advances in drug therapy of neonatal hypertension.
authors.affiliation: Department of Pediatrics, Section of Nephrology, Ali-Asghar Children's Hospital, Iran University Medical Sciences, Tehran, Iran.
authors.forename: Azar
authors.initials: A
authors.lastname: Nickavar
authors.affiliation: Departments of Pediatrics, Section of Nephrology, Rush Children's Hospital, Rush University Medical Center, Chicago, Illinois, USA, and Child Growth Development Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farahnak
authors.initials: F
authors.lastname: Assadi
keywords: Blood pressure; diagnosis; evaluation; hypertension; neonates; treatment