title: Current trends in bone tissue engineering.
abstract: The development of tissue engineering and regeneration constitutes a new platform for translational medical research. Effective therapies for bone engineering typically employ the coordinated manipulation of cells, biologically active signaling molecules, and biomimetic, biodegradable scaffolds. Bone tissue engineering has become increasingly dependent on the merging of innovations from each of these fields, as they continue to evolve independently. This foreword will highlight some of the most recent advances in bone tissue engineering and regeneration, emphasizing the interconnected fields of stem cell biology, cell signaling biology, and biomaterial research. These include, for example, novel methods for mesenchymal stem cell purification, new methods of Wnt signaling pathway manipulation, and cutting edge computer assisted nanoscale design of bone scaffold materials. In the following special issue, we sought to incorporate these diverse areas of emphasis in order to reflect current trends in the field.
authors.affiliation: Department of Pathology & Laboratory Medicine, and Orthopedic Hospital Research Center, University of California, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, A3-251 CHS, Los Angeles, CA 90095, USA.
authors.forename: Marco
authors.identifier: 0000-0001-6294-1824
authors.initials: M
authors.lastname: Mravic
authors.affiliation: Department of Pathology & Laboratory Medicine, and Orthopedic Hospital Research Center, University of California, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, A3-251 CHS, Los Angeles, CA 90095, USA.
authors.forename: Bruno
authors.initials: B
authors.lastname: Péault
authors.affiliation: Department of Pathology & Laboratory Medicine, and Orthopedic Hospital Research Center, University of California, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, A3-251 CHS, Los Angeles, CA 90095, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration / Q000235:genetics*; D017076:Computer-Aided Design; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds / Q000639:trends; D060449:Wnt Signaling Pathway / Q000235:genetics*
chemical_list: D001672:Biocompatible Materials