title: Long-term changes in straylight induced by corneal refractive therapy: a pilot study.
abstract: OBJECTIVE
  To assess long-term intraocular straylight changes induced by corneal refractive therapy (CRT) and to determine whether these changes persist after cessation of CRT lens wear.
  
  
  METHODS
  A single-center, prospective, longitudinal study was performed in 22 subjects (group 1) undergoing overnight corneal refractive therapy for 1 year. Ten right eyes of 10 subjects (group 2) with emmetropia served as controls. In each subject, high contrast visual acuity (HCVA), manifest refraction and intraocular straylight were determined at several time points during treatment and 1 month after discontinuing treatment. Straylight was measured using the van den Berg straylight meter (third generation). EDTRS charts (logMAR units) were used to assess HCVA. For both groups, only data for the right eyes were analyzed.
  
  
  RESULTS
  Straylight (mean ± standard deviation) significantly fell from baseline (0.98 ± 0.13) to values recorded after 1 month (0.88 ± 0.13, p=0.011), 3 months (0.88 ± 0.13, p=0.004), 6 months (0.88 ± 0.13, p=0.000) and 12 months (0.76 ± 0.12, p=0.003) of treatment. One month after discontinuing CRT lens wear, straylight was still significantly lower than baseline (0.89 ± 0.13, p=0.003). No correlations were observed between intraocular straylight and HCVA.
  
  
  CONCLUSIONS
  Good refractive outcomes and reductions in straylight were observed in response to corneal refractive therapy for myopia. The reduction in straylight observed after discontinuing CRT warrents further investigation.
authors.affiliation: Departament of Optics II, Copmplutense University of Madrid, Spain. Electronic address: alorente@ucm.es.
authors.forename: Amalia
authors.initials: A
authors.lastname: Lorente-Velázquez
authors.affiliation: Departament of Optics II, Copmplutense University of Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: González Mesa
authors.affiliation: Clínica Novovisión, Madrid, Spain.
authors.forename: Jose Ramón
authors.initials: JR
authors.lastname: Gutierrez
authors.affiliation: Clínica Novovisión, Madrid, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Villa-Collar
authors.affiliation: Departament of Optics II, Copmplutense University of Madrid, Spain.
authors.forename: Amelia
authors.initials: A
authors.lastname: Nieto-Bona
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008027:Light; D008137:Longitudinal Studies; D008297:Male; D009216:Myopia / Q000175:diagnosis* / Q000628:therapy*; D054158:Orthokeratologic Procedures / Q000009:adverse effects* / Q000379:methods*; D010865:Pilot Projects; D020127:Recovery of Function; D012029:Refraction, Ocular; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology*; D055815:Young Adult
keywords: Cornea; Corneal refractive therapy; Intraocular straylight