title: Angiotensin II and 1-7 during aging in Metabolic Syndrome rats. Expression of AT1, AT2 and Mas receptors in abdominal white adipose tissue.
abstract: Renin-Angiotensin System (RAS) plays an important role in the development of Metabolic Syndrome (MS) and in aging. Angiotensin 1-7 (Ang 1-7) has opposite effects to Ang II. All of the components of RAS are expressed locally in adipose tissue and there is over-activation of adipose RAS in obesity and hypertension. We determined serum and abdominal adipose tissue Ang II and Ang 1-7 in control and MS rats during aging and the expression of AT1, AT2 and Mas in white adipose tissue. MS was induced by sucrose ingestion during 6, 12 and 18 months. During aging, an increase in body weight, abdominal fat and dyslipidemia were found but increases in aging MS rats were higher. Control and MS concentrations of serum Ang II from 6-month old rats were similar. Aging did not modify Ang II seric concentration in control rats but decreased it in MS rats. Ang II levels increased in WAT from both groups of rats. Serum and adipose tissue Ang 1-7 increased during aging in MS rats. Western blot analysis revealed that AT1 expression increased in the control group during aging while AT2 and Mas remained unchanged. In MS rats, AT1 and AT2 expression decreased significantly in aged rats. The high concentration of Ang 1-7 and adiponectin in old MS rats might be associated to an increased expression of PPAR-γ. PPAR-γ was increased in adipose tissue from MS rats. It decreased with aging in control rats and showed no changes during aging in MS rats. Ang 1-7/Mas axis was the predominant pathway in WAT from old MS animals and could represent a potential target for therapeutical strategies in the treatment of MS during aging.
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico D.F., Mexico.
authors.forename: M E
authors.initials: ME
authors.lastname: Rubio-Ruíz
authors.affiliation: Department of Pharmacology, Instituto Nacional de Cardiología ``Ignacio Chávez'' Mexico D.F., Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Del Valle-Mondragón
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico D.F., Mexico.
authors.forename: V
authors.initials: V
authors.lastname: Castrejón-Tellez
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología ``Ignacio Chávez'' Mexico D.F., Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Carreón-Torres
authors.affiliation: Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y de la Nutrición "Salvador Zubirán", Mexico D.F., Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Díaz-Díaz
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico D.F., Mexico. Electronic address: gualanv@yahoo.com.
authors.forename: V
authors.initials: V
authors.lastname: Guarner-Lans
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000473:pathology; D024821:Metabolic Syndrome / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D051381:Rats; D044139:Receptor, Angiotensin, Type 2 / Q000096:biosynthesis*; D011945:Receptors, Angiotensin / Q000096:biosynthesis*; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis*; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: C524087:Agtrap protein, rat; D010446:Peptide Fragments; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D043562:Receptors, G-Protein-Coupled; D000804:Angiotensin II; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: Age; Metabolic Syndrome; Renin-Angiotensin System; White adipose tissue