title: Challenges in providing critical care for patients with anti-N-methyl-D-aspartate receptor encephalitis.
abstract: Anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is characterized by a constellation of psychiatric, neurologic, autonomic, and cardiopulmonary manifestations. Although patients typically recover with appropriate treatment, they commonly require weeks to months of inpatient care, including prolonged stays in critical care units. This case series not only advocates for consideration of the disease in the appropriate context but also specifically highlights the distinct challenges intensivists encounter caring for patients with NMDARE. With a greater knowledge of the nuances and sequelae of NMDARE, critical care specialists will be better equipped to anticipate and manage the potentially life-threatening complications of the disease.
authors.affiliation: Pulmonary, Critical Care, and Sleep Section, Baylor College of Medicine. Electronic address: ch5@bcm.edu.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Howard
authors.affiliation: Department of Neurology, Baylor College of Medicine; Department of Neurology, Ben Taub General Hospital, Houston, TX.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Kass
authors.affiliation: Pulmonary, Critical Care, and Sleep Section, Baylor College of Medicine; Medical Intensive Care Unit, Ben Taub General Hospital, Houston, TX.
authors.forename: Venkata D P
authors.initials: VDP
authors.lastname: Bandi
authors.affiliation: Pulmonary, Critical Care, and Sleep Section, Baylor College of Medicine; Medical Intensive Care Unit, Ben Taub General Hospital, Houston, TX.
authors.forename: Kalpalatha K
authors.initials: KK
authors.lastname: Guntupalli
mesh_terms: D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000175:diagnosis / Q000628:therapy*; D002555:Cerebrospinal Fluid / Q000737:chemistry; D015928:Cognitive Behavioral Therapy / Q000379:methods; D003422:Critical Care / Q000592:standards / Q000639:trends*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage; D007275:Injections, Intravenous; D010951:Plasma Exchange / Q000379:methods*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology / Q000378:metabolism; D012121:Respiration, Artificial / Q000379:methods*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D016194:Receptors, N-Methyl-D-Aspartate