title: Fetal intestinal perforation and meconium peritonitis associated with maternal autoimmune hepatitis.
abstract: Autoimmune hepatitis (AIH) in pregnancy can affect both fetal and maternal outcomes. Little is known regarding the fetal outcomes of AIH in pregnancy. The major risks include spontaneous abortions, fetal mortality, perinatal mortality and prematurity. Two common drugs used in the management of AIH, azathioprine and prednisone, may also be associated with adverse fetal outcomes. We present the case of perinatal focal intestinal perforation with a meconium pseudocyst in a preterm infant of a mother with autoimmune hepatitis on azathioprine and methylprednisone.
authors.affiliation: Department of Pediatrics, New York Methodist Hospital, Brooklyn, NY, USA.
authors.forename: P
authors.initials: P
authors.lastname: Charlagorla
authors.affiliation: Saint George's University School of Medicine, True Blue, Grenada.
authors.forename: S
authors.initials: S
authors.lastname: Sublett
authors.affiliation: Department of Pediatrics, New York Methodist Hospital, Brooklyn, NY, USA.
authors.forename: F
authors.initials: F
authors.lastname: Sy
authors.affiliation: Department of Surgery, New York Methodist Hospital, Brooklyn, NY, USA.
authors.forename: E
authors.initials: E
authors.lastname: Kessler
authors.affiliation: Department of Pediatrics, New York Methodist Hospital, Brooklyn, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gad
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects; D013293:Enterococcus faecalis / Q000302:isolation & purification; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000601:surgery; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007081:Ileostomy; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007231:Infant, Newborn; D007234:Infant, Premature; D007416:Intestinal Perforation / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000601:surgery; D007813:Laparotomy; D008297:Male; D008470:Meconium / Q000000981:diagnostic imaging* / Q000382:microbiology; D010538:Peritonitis / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000601:surgery; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007166:Immunosuppressive Agents; D000667:Ampicillin; D001379:Azathioprine
keywords: Fetal intestinal perforation; autoimmune hepatitis; azathioprine; meconium peritonitis