title: [Proliferation of adult mammalian ventricular cardiomyocytes: a sporadic but feasible phenomenon].
abstract: Proliferation of adult mammalian ventricular cardiomyocytes has been ruled out by some researchers, who have argued that these cells are terminally differentiated; however, this dogma has been rejected because other researchers have reported that these cells can present the processes necessary to proliferate, that is, DNA synthesis, mitosis and cytokinesis when the heart is damaged experimentally through pharmacological and surgical strategies or due to pathological conditions concerning the cardiovascular system. This review integrates some of the available works in the literature evaluating the DNA synthesis, mitosis and cytokinesis in these myocytes, when the myocardium is damaged, with the purpose of knowing if their proliferation can be considered as a feasible phenomenon. The review is concluded with a reflection about the perspectives of the knowledge generated in this area.
authors.affiliation: Departamento de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., México. Electronic address: varalv@cardiologia.org.mx.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Vargas-González
mesh_terms: D000328:Adult; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D048749:Cytokinesis; D004247:DNA / Q000096:biosynthesis*; D004285:Dogs; D006352:Heart Ventricles / Q000166:cytology*; D006801:Humans; D051379:Mice; D008938:Mitosis / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D012333:RNA, Messenger; D004247:DNA; D001973:Bromodeoxyuridine
keywords: Adult stage; Citocinesis y desdiferenciación; Cytokinesis and dedifferentiation; DNA synthesis; Etapa adulta; Mexico; Miocitos cardíacos ventriculares; Mitosis; México; Proliferación; Proliferation; Síntesis de ADN; Ventricular cardiomyocytes