title: Effect of oral ondansetron on decreasing the vomiting associated with acute gastroenteritis in Iranian children.
abstract: OBJECTIVE
  The aim of this study was to determine the effect of oral ondansetron in decreasing the vomiting due to acute gastroenteritis in children.
  
  
  METHODS
  In a single center, randomized, double blind, controlled trial, the effect of oral ondansetron was compared with placebo on 176 patients between 1 and 10 years old with acute gastroenteritis. 30 minutes after drug administration, oral rehydration therapy (ORT) was initiated. Severity of vomiting was evaluated during emergency department (ED) stay and 48 hours follow up. Data were collected and analyzed by SPSS16.
  
  
  RESULTS
  Fifty two of children (58.5%) were males with the mean age of 3.12 (±2.30) years. Ten patients in ondansetron and 14 in placebo group had persistent vomiting during ED stay. After analyzing, there was no significant relation between vomiting in 4 and 48 hours and need for intra venous fluid therapy between the two groups although ondansetron generally decreased ORT failure (P=0.03).
  
  
  CONCLUSIONS
  Although administrayion of oral ondansetron in gastroenteritis could decrease failure of ORT, it seems that further well-conducted clinical studies are needed to determine effects of oral ondansetron precisely.
authors.affiliation: Pediatrics Growth Disorders Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Kioomars
authors.initials: K
authors.lastname: Golshekan
authors.affiliation: Pediatrics Growth Disorders Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Badeli
authors.affiliation: Pediatrics Growth Disorders Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Rezaieian
authors.affiliation: Pediatrics Growth Disorders Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Haniyeh
authors.initials: H
authors.lastname: Mohammadpour
authors.affiliation: Pediatrics Growth Disorders Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Afagh
authors.initials: A
authors.lastname: Hassanzadehrad
keywords: Acute Gastroenteritis; Ondansetron; Oral Rehydration Therapy; Vomiting