title: Resisting protein adsorption on biodegradable polyester brushes.
abstract: The protein adsorption and degradation behaviors of poly(lactic acid), poly(glycolic acid) (PGA) and poly(ε-caprolactone) (PCL) brushes and their co-polymer brushes with oligo(ethylene glycol) (OEG) were studied. Both brush structure and relative amount of OEG and polyester were found to be important to the protein resistance of the brushes. A protein-resisting surface can be fabricated either by using OEG as the top layer of a copolymer brush or by increasing the amount of OEG relative to polyester when using a hydroxyl terminated OEG (OEG-OH) and a methoxy terminated OEG (OEG-OMe) mixture as the substrate layer. The degradation of single polyester brushes and their co-polymer brushes using OEG-OH as a substrate layer or using OEG as a top layer was hindered. This phenomenon was rationalized by the inhibition of the proposed back-biting process as the hydroxy end groups of polyester were blocked by OEG molecules. Among these brushes tested, PGA co-polymer brushes using the methoxy/hydroxyl OEG mixture as the substrate layer proved to be both protein-resistant and degradable due to the relatively large amount of OEG moieties and the good biodegradability of PGA.
authors.affiliation: Department of Chemistry, North Carolina State University, Box 8204, Raleigh, NC 27695, USA.
authors.forename: Xinfang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Chemistry, North Carolina State University, Box 8204, Raleigh, NC 27695, USA. Electronic address: cbgorman@ncsu.edu.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Gorman
mesh_terms: D020341:Absorbable Implants; D001665:Binding Sites; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; D012710:Serum Albumin, Bovine
keywords: Adsorption; Copolymer; Degradation; Electrochemistry; Polyester