title: Evaluation of renal quantitative T2* changes on MRI following administration of ferumoxytol as a T2* contrast agent.
abstract: OBJECTIVE
  To evaluate the time-dependent changes in regional quantitative T2* maps of the kidney following intravenous administration of ferumoxytol.
  
  
  METHODS
  Twenty-four individuals with normal kidney function underwent T2*-weighted MRI of the kidney before, immediately after, and 48 hours after intravenous administration of ferumoxytol at a dose of 4 mg/kg (group A, n=12) or 6 mg/kg (group B, n=12). T2* values were statistically analyzed using two-tailed paired t-tests.
  
  
  RESULTS
  In group A, the percentage changes from baseline to immediate post and baseline to 48 hours were 85.3% and 64.2% for the cortex and 90.8% and 64.6% for the medulla, respectively. In group B, the percentage changes from baseline to immediate post and baseline to 48 hours were 85.2% and 73.4% for the cortex and 94.5% and 74% for the medulla, respectively. This difference was significant for both groups (P<0.0001).
  
  
  CONCLUSIONS
  There is significant and differential uptake of ferumoxytol in the cortex and medulla of physiologically normal kidneys. This differential uptake may offer the ability to interrogate renal cortex and medulla with possible clinical applications in medical renal disease and transplant organ assessment. We propose an organ of interest based dose titration of ferumoxytol to better differentiate circulating from intracellular ferumoxytol particles.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Richard B Simches Research Center, Boston, MA, USA.
authors.forename: Sandeep S
authors.initials: SS
authors.lastname: Hedgire
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Richard B Simches Research Center, Boston, MA, USA.
authors.forename: Shaunagh
authors.initials: S
authors.lastname: McDermott
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Richard B Simches Research Center, Boston, MA, USA.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Wojtkiewicz
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Richard B Simches Research Center, Boston, MA, USA.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Abtahi
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Richard B Simches Research Center, Boston, MA, USA.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Harisinghani
authors.affiliation: Joslin Diabetes Center, Boston, MA, USA.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Gaglia
mesh_terms: D000328:Adult; D000368:Aged; D003198:Computer Simulation; D003287:Contrast Media / Q000737:chemistry; D005260:Female; D052203:Ferrosoferric Oxide / Q000494:pharmacology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007668:Kidney / Q000033:anatomy & histology / Q000378:metabolism*; D007677:Kidney Function Tests / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: D003287:Contrast Media; D052203:Ferrosoferric Oxide
keywords: T2* weighted imaging; USPIO; ferumoxytol; renal MRI