title: Mobile phone use and brain tumours in the CERENAT case-control study.
abstract: The carcinogenic effect of radiofrequency electromagnetic fields in humans remains controversial. However, it has been suggested that they could be involved in the aetiology of some types of brain tumours.
  
  
  OBJECTIVE
  The objective was to analyse the association between mobile phone exposure and primary central nervous system tumours (gliomas and meningiomas) in adults.
  
  
  METHODS
  CERENAT is a multicenter case-control study carried out in four areas in France in 2004-2006. Data about mobile phone use were collected through a detailed questionnaire delivered in a face-to-face manner. Conditional logistic regression for matched sets was used to estimate adjusted ORs and 95% CIs.
  
  
  RESULTS
  A total of 253 gliomas, 194 meningiomas and 892 matched controls selected from the local electoral rolls were analysed. No association with brain tumours was observed when comparing regular mobile phone users with non-users (OR=1.24; 95% CI 0.86 to 1.77 for gliomas, OR=0.90; 95% CI 0.61 to 1.34 for meningiomas). However, the positive association was statistically significant in the heaviest users when considering life-long cumulative duration (≥896 h, OR=2.89; 95% CI 1.41 to 5.93 for gliomas; OR=2.57; 95% CI 1.02 to 6.44 for meningiomas) and number of calls for gliomas (≥18,360 calls, OR=2.10, 95% CI 1.03 to 4.31). Risks were higher for gliomas, temporal tumours, occupational and urban mobile phone use.
  
  
  CONCLUSIONS
  These additional data support previous findings concerning a possible association between heavy mobile phone use and brain tumours.
authors.affiliation: Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France CHU de Bordeaux, Service d'information médicale, Bordeaux, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Coureau
authors.affiliation: Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France.
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Bouvier
authors.affiliation: INSERM, UMR1086-Cancers et Préventions, Caen, France Univ. Caen Basse-Normandie, Caen, France Centre François Baclesse, Caen, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lebailly
authors.affiliation: Laboratoire d'Epidémiologie et de Biostatistiques, Univ. Montpellier, Institut Universitaire de Recherche Clinique, Montpellier, France Département d'informatique médicale, CHU de Nîmes, Nîmes, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Fabbro-Peray
authors.affiliation: Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Gruber
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Leffondre
authors.affiliation: Département de neurologie, CHU de Caen, Caen, France.
authors.forename: Jean-Sebastien
authors.initials: JS
authors.lastname: Guillamo
authors.affiliation: Service de Neurochirurgie, CHU de Bordeaux, Bordeaux, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Loiseau
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France.
authors.forename: Simone
authors.initials: S
authors.lastname: Mathoulin-Pélissier
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France CHU de Bordeaux, Service d'information médicale, Bordeaux, France.
authors.forename: Roger
authors.initials: R
authors.lastname: Salamon
authors.affiliation: Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France Service de Médecine du Travail, CHU de Bordeaux, Bordeaux, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Baldi
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D040421:Cell Phone; D005260:Female; D005910:Glioma / Q000209:etiology*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology*; D008579:Meningioma / Q000209:etiology*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects; D016017:Odds Ratio; D011846:Radio Waves / Q000009:adverse effects*; D012307:Risk Factors; D014505:Urban Population
keywords: Case-control studies; Electromagnetic fields; Glioma; Meningioma; Mobile phone; Radiofrequency electromagnetic fields