title: Presentation, therapy and outcome of patients with ischemic stroke under new oral anticoagulants.
abstract: BACKGROUND
  Aim was to describe the clinical spectrum, therapy, and outcome of ischemic strokes under therapy with new oral anticoagulants (NOAC).
  
  
  RESULTS
  A literature research was carried out in PubMed. Clinical trials as well as case reports were included. Four large trials comparing NOAC with warfarin reported 469 ischemic strokes but neither co-medication, nor comorbidities, location, clinical spectrum, therapy, nor outcome are reported. Eleven cases with ischemic strokes under dabigatran from the literature are reported. Six patients received thrombolytic therapy, in three of them unaware dabigatran therapy. Two patients received mechanical recanalization. Two patients died, one due to cerebral hemorrhage after thrombolysis, the other after partial recanalization of the basilar artery.
  
  
  CONCLUSIONS
  Little is known about ischemic strokes under NOAC. To increase the knowledge, the data of 469 ischemic strokes which occurred in NOAC-investigating trials should be analyzed. Furthermore ischemic and bleeding events under NOAC outside clinical trials should be reported. An international registry, independent from the pharmaceutical industry for collecting these informations is desirable.
authors.affiliation: Hospital Rudolf-Foundation, Wien, Austria. Electronic address: claudia.stoellberger@chello.at.
authors.forename: Claudia
authors.initials: C
authors.lastname: Stöllberger
authors.affiliation: Hospital Rudolf-Foundation, Wien, Austria.
authors.forename: Josef
authors.initials: J
authors.lastname: Finsterer
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy*; D006801:Humans; D020521:Stroke / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants
keywords: Atrial fibrillation; Dabigatran; Rivaroxaban; Stroke; Thrombolysis