title: Uterine transplantation in primates: a mini-review of the literature.
abstract: Assisted reproductive technology has improved markedly in recent years, and many infertile patients have had children with the use of this technology. However, women with infertility due to an absent or nonfunctional uterus currently have no option of having a genetically linked child other than gestational surrogacy. Uterus transplantation (UTx) is now a possible approach for women with uterine-factor infertility to deliver a child. UTx studies have been performed in many animals, and accumulation of data from these studies has brought UTx within reach of clinical application. This has led to performance of UTx in humans in Saudi Arabia, Turkey, and Sweden. However, there has yet to be a delivery after allogeneic UTx in primates. More basic studies in primates are needed, and data from research in primates can provide important information for establishment of UTx in humans. In this review, we summarize the literature on UTx studies, with a focus on primates, both human and nonhuman.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kisu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan. Electronic address: kbanno@z7.keio.jp.
authors.forename: K
authors.initials: K
authors.lastname: Banno
authors.affiliation: Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.affiliation: Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.affiliation: Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Suganuma
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Aoki
mesh_terms: D000818:Animals; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology / Q000601:surgery*; D023421:Models, Animal; D011247:Pregnancy; D011323:Primates; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D014599:Uterus / Q000637:transplantation*