title: A selective, long-lived deep-red emissive ruthenium(II) polypyridine complexes for the detection of BSA.
abstract: A selective, label free luminescence sensor for bovine serum albumin (BSA) is investigated using ruthenium(II) complexes over the other proteins. Interaction between BSA and ruthenium(II) complexes has been studied using absorption, emission, excited state lifetime and circular dichroism (CD) spectral techniques. The luminescence intensity of ruthenium(II) complexes (I and II), has enhanced at 602 and 613 nm with a large hypsochromic shift of 18 and 5 nm respectively upon addition of BSA. The mode of binding of ruthenium(II) complexes with BSA has analyzed using computational docking studies.
authors.affiliation: Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India; Department of Chemistry, VV College of Engineering, Tisaiyanvilai, Tirunelveli, India.
authors.forename: Eththilu
authors.initials: E
authors.lastname: Babu
authors.affiliation: Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India; Graduate School of EEWS (WCU), Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
authors.forename: Paulpandian
authors.initials: P
authors.lastname: Muthu Mareeswaran
authors.affiliation: Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Singaravadivel
authors.affiliation: Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India; Department of Chemistry, SRI G.V.G Visalakshi College for Women, Udumalapet, Tamil Nadu, India.
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Bhuvaneswari
authors.affiliation: Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India. Electronic address: rajagopalseenivasan@yahoo.com.
authors.forename: Seenivasan
authors.initials: S
authors.lastname: Rajagopal
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002021:Buffers; D002417:Cattle; D002712:Chlorides / Q000737:chemistry; D002942:Circular Dichroism; D003198:Computer Simulation; D007700:Kinetics; D049449:Luminescence; D010710:Phosphates / Q000737:chemistry; D011485:Protein Binding; D017433:Protein Structure, Secondary; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012984:Software
chemical_list: D002021:Buffers; D002712:Chlorides; D010710:Phosphates; D011725:Pyridines; D012710:Serum Albumin, Bovine; D012428:Ruthenium
keywords: Biosensor; Bovine serum albumin (BSA); Docking; Luminescence; Ruthenium(II) complex