title: Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging.
abstract: We report stamping surface-enhanced Raman spectroscopy (S-SERS) for label-free, multiplexed, molecular sensing and large-area, high-resolution molecular imaging on a flexible, nonplasmonic surface without solution-phase molecule transfer. In this technique, a polydimethylsiloxane (PDMS) thin film and nanoporous gold disk SERS substrate play the roles as molecule carrier and Raman signal enhancer, respectively. After stamping the SERS substrate onto the PDMS film, SERS measurements can be directly taken from the "sandwiched" target molecules. The performance of S-SERS is evaluated by the detection of Rhodamine 6G, urea, and its mixture with acetaminophen, in a physiologically relevant concentration range, along with the corresponding SERS spectroscopic maps. S-SERS features simple sample preparation, low cost, and high reproducibility, which could lead to SERS-based sensing and imaging for point-of-care and forensics applications.
authors.affiliation: University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204.
authors.forename: Ji
authors.initials: J
authors.lastname: Qi
authors.affiliation: University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Sam Houston State University, Forensic Science Program, 1003 Bowers Boulevard, Huntsville, Texas 77341.
authors.forename: Jorn Chi-Chung
authors.initials: JC
authors.lastname: Yu
authors.affiliation: University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204.
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Shih
mesh_terms: D004129:Dimethylpolysiloxanes; D057054:Molecular Imaging / Q000379:methods*; D049329:Nanostructures; D009757:Nylons; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D004129:Dimethylpolysiloxanes; D009757:Nylons; C085707:poly(dimethylsiloxane)-polyamide copolymer