An investigation of the white matter microstructure in motion detection using diffusion MRI.
One of the most widely investigated functions of the brain is vision. Whereas special attention is often paid to motion detection and its modulation by attention, comparatively still little is known about the structural background of this function. We therefore, examined the white matter microstructural background of coherent motion detection. A random-dot kinematogram paradigm was used to measure the sensitivity of healthy individuals׳ to movement coherence. The potential correlation was investigated between the motion detection threshold and the white matter microstructure as measured by high angular resolution diffusion MRI. The Track Based Spatial Statistics method was used to address this correlation and probabilistic tractography to reveal the connection between identified regions. A significant positive correlation was found between the behavioural data and the local fractional anisotropy in the posterior part of the right superior frontal gyrus, the right juxta-cortical superior parietal lobule, the left parietal white matter, the left superior temporal gyrus and the left optic radiation. Probabilistic tractography identified pathways that are highly similar to the segregated attention networks, which have a crucial role in the paradigm. This study draws attention to the structural determinant of a behavioural function.
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.
Gergő
G
Csete
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary; International Clinical Research Centre, St. Anne׳s University Hospital, Brno, Czech Republic.
Nikoletta
N
Szabó
Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Alice
A
Rokszin
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.
Eszter
E
Tóth
Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Gábor
G
Braunitzer
Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
György
G
Benedek
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary; MTA-SZTE Neuroscience Research Group, Semmelweis u. 6, H-6725 Szeged, Hungary.
László
L
Vécsei
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary; International Clinical Research Centre, St. Anne׳s University Hospital, Brno, Czech Republic. Electronic address: kincses.zsigmond.tamas@med.u-szeged.hu.
Zsigmond Tamás
ZT
Kincses
D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D004056:Differential Threshold / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D010775:Photic Stimulation; D011601:Psychophysics; D017603:Signal Detection, Psychological / Q000502:physiology*; D066127:White Matter / Q000033:anatomy & histology* / Q000502:physiology*; D055815:Young Adult
DTI; MRI; Motion detection; Vision; White matter microstructure