Efficiency of pancreatic duct stenting therapy in children with chronic pancreatitis.
BACKGROUND
Chronic pancreatitis (CP) is a rare disease in childhood. Although ERCP is commonly performed in children, the effect of pancreatic duct stenting therapy in children with CP is unknown.


OBJECTIVE
To investigate the efficacy of pancreatic duct stenting in children with CP.


METHODS
Retrospective analysis.


METHODS
National referral center.


METHODS
A total of 208 children with CP hospitalized between 1988 and 2012.


METHODS
ERCP with pancreatic duct stenting.


METHODS
Results of endoscopic therapy and number of pancreatitis episodes per year before and after treatment.


RESULTS
A total of 223 pancreatic duct stenting procedures were performed in 72 children. The median number of stent replacements was 3 (range 1-21). A statistically significant decrease in the number of pancreatitis episodes per year was observed: from 1.75 to 0.23 after endoscopic treatment (P < .05). Pancreatic duct stenting was performed more frequently in patients with hereditary pancreatitis (61.5%) and in children with CP and anatomic anomalies of the pancreatic duct (65%; P < .05).


CONCLUSIONS
Retrospective analysis with the assessment of adverse events based on medical history.


CONCLUSIONS
Pancreatic duct stenting therapy is a safe and effective procedure in children with CP. This therapy should be recommended especially for children with hereditary pancreatitis and patients with anatomic anomalies of the pancreatic duct.
Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
Grzegorz
G
Oracz
Endoterapia, Warsaw, Poland.
Jan
J
Pertkiewicz
Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
Jaroslaw
J
Kierkus
Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
Maciej
M
Dadalski
Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
Jerzy
J
Socha
Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
Jozef
J
Ryzko
D000293:Adolescent; D001327:Autoimmune Diseases / Q000150:complications; D002648:Child; D002675:Child, Preschool; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods*; D015331:Cohort Studies; D004065:Digestive System Abnormalities / Q000150:complications; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010183:Pancreatic Ducts / Q000601:surgery*; D050500:Pancreatitis, Chronic / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome