Flow cytometric monitoring of the in vitro inhibition of the phosphorylation of CRKL and of SRC family kinases in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors.
Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Department of Hemato-Oncology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
L
L
Krupkova
R
R
Mojzikova
J
J
Novotny
J
J
Gazdova
M
M
Divoka
I
I
Skoumalova
P
P
Rohon
M
M
Jarosova
K
K
Indrak
E
E
Faber
V
V
Divoky
D048868:Adaptor Proteins, Signal Transducing / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000378:metabolism*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
D048868:Adaptor Proteins, Signal Transducing; D000970:Antineoplastic Agents; C082869:CRKL protein; D009687:Nuclear Proteins; D047428:Protein Kinase Inhibitors; D019061:src-Family Kinases