The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process.
Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14) cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber veins located at the peripheral capsular region or within the collagenous septae of the tumors.
Department of Pathology, National University Health System Hospital, Singapore, Singapore.
Fredrik
F
Petersson
Jindrich
J
Branzovsky
Petr
P
Martinek
Marie
M
Korabecna
Bozo
B
Kruslin
Milan
M
Hora
Kvetoslava
K
Peckova
Kevin
K
Bauleth
Kristyna
K
Pivovarcikova
Michal
M
Michal
Marian
M
Svajdler
Maris
M
Sperga
Stela
S
Bulimbasic
Xavier
X
Leroy
Boris
B
Rychly
Sandra
S
Trivunic
Bohuslava
B
Kokoskova
Pavla
P
Rotterova
Miroslav
M
Podhola
Saul
S
Suster
Ondrej
O
Hes
D018262:Adenocarcinoma, Clear Cell / Q000473:pathology; D000231:Adenocarcinoma, Papillary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002999:Clone Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D007889:Leiomyoma / Q000473:pathology*; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis
D011944:Receptors, Androgen