Synthetic versus natural receptors: supramolecular control of chemical sensing in fish.
The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.
CIQA, Faculdade de Ciências e Tecnologia and ⊥CCMAR, Universidade do Algarve , Campus de Gambelas 8005-139 Faro Portugal.
José P
JP
Da Silva
Rajib
R
Choudhury
Mintu
M
Porel
Uwe
U
Pischel
Steffen
S
Jockusch
Peter C
PC
Hubbard
Vaidhyanathan
V
Ramamurthy
Adelino V M
AV
Canário
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000378:metabolism*; D002103:Cadaverine / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D008958:Models, Molecular; D018035:Receptors, Odorant / Q000378:metabolism*; D012903:Smell; D017210:Tilapia / Q000502:physiology*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D000218:Adamantane; D001952:Bridged-Ring Compounds; D002103:Cadaverine; D007093:Imidazoles; D018035:Receptors, Odorant; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils