Role of neutrophil extracellular traps following injury.
Neutrophil extracellular traps (NETs), which consist of neutrophil DNA and cytoplasmic proteins, have been shown to be involved in various infectious, inflammatory, and autoimmune diseases. Neutrophil extracellular traps are abundant at the site of infection and acute inflammation. Neutrophil extracellular trap formation can occur through various intracellular signaling pathways, including peptidylarginine deiminase 4, Raf-MEK-ERK, nitric oxide, Toll-like receptor 4, high mobility group box 1, pentraxin 3, and mammalian targets of rapamycin. A growing body of evidence indicates that NETs may play an important role in injury, and decreases in NETs could reduce tissue injury. Neutrophil extracellular traps are believed to modulate the inflammatory and immune responses of individuals after injury. In this review, the role of NETs in injury, including traumatic injury, ischemia-reperfusion-induced injury, and sepsis, as well as the potential markers and therapeutic targets of NET-related injury will be discussed.
*Department of Anesthesiology, Chang Gung Memorial Hospital; and †College of Medicine, Chang Gung University, Taoyuan; and ‡Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
Fu-Chao
FC
Liu
Yueh-Hsun
YH
Chuang
Yung-Fong
YF
Tsai
Huang-Ping
HP
Yu
D000818:Animals; D065206:Extracellular Traps / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction; D014947:Wounds and Injuries / Q000503:physiopathology*