Investigating the solubility and cytocompatibility of CaO-Na2 O-SiO2 /TiO2 bioactive glasses.
This study aims to investigate the solubility of a series of titanium (TiO2 )-containing bioactive glasses and their subsequent effect on cell viability. Five glasses were synthesized in the composition range SiO2 -Na2 O-CaO with 5 mol % of increments TiO2 substituted for SiO2 . Glass solubility was investigated with respect to (1) exposed surface area, (2) particle size, (3) incubation time, and (4) compositional effects. Ion release profiles showed that sodium (Na(+) ) presented high release rates after 1 day and were unchanged between 7 and 14 days. Calcium (Ca(2+) ) release presented a significant change at each time period and was also composition dependent, where a reduction in Ca(2+) release is observed with an increase in TiO2 concentration. Silica (Si(4+) ) release did not present any clear trends while no titanium (Ti(4+) ) was released. Cell numbers were found to increase up to 44%, compared to the growing control population, with a reduction in particle size and with the inclusion of TiO2 in the glass composition.
Inamori School of Engineering, Alfred University, Alfred, New York.
Anthony W
AW
Wren
Aisling
A
Coughlan
Courtney M
CM
Smith
Sarah P
SP
Hudson
Fathima R
FR
Laffir
Mark R
MR
Towler
D000818:Animals; D002118:Calcium / Q000737:chemistry*; D002460:Cell Line; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D012995:Solubility; D014025:Titanium / Q000737:chemistry*
C009495:titanium dioxide; D014025:Titanium; D002118:Calcium
bioactive glass; cell culture; ion release; particle size; solubility