Association between the NFKB1-94ins/del ATTG polymorphism and cancer risk: an updated meta-analysis.
To assess the effect of the NFKB1 -94ins/del polymorphism on cancer, we conducted a meta-analysis based on 25 studies including 8,750 cases and 9,170 controls. Overall, the -94ins/del polymorphism was associated with cancer risk in the pooled analysis and in Asian population, whereas no association was observed in Caucasian population. Stratified analysis by subtypes of cancer showed that the -94ins/del polymorphism was associated with oral squamous cell carcinoma and ovarian cancer risk, but had no association with colorectal cancer, bladder cancer, and renal cell cancer. Our meta-analysis suggests the NFKB1 -94ins/del polymorphism affects cancer susceptibility, and the association is ethnic-specific.
1Institute of Cardiovascular Disease, General Hospital of Jinan Military Region, Jinan, Shandong, China.
Wenyuan
W
Duan
Erli
E
Wang
Fengquan
F
Zhang
Tongjian
T
Wang
Xiangdong
X
You
Bin
B
Qiao
D044466:Asian People / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000235:genetics; D044465:White People / Q000235:genetics
D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human
Cancer genetics; Carcinogenesis; Risk and prevention