Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model.
BACKGROUND
Polymer-free drug-eluting stents (DES) may overcome the shortcomings of polymer-based DES. The aim of this study was to examine the effect of the polymer-free TiO2 film-coated stent with abciximab or alpha lipoic acid in a porcine coronary overstretch restenosis model.


METHODS
Pigs were randomized into four groups in which the coronary arteries (24 pigs, 48 coronaries in each group) had TiO2 film-coated stent with abciximab (TCA, n = 12), TiO2 film-coated stent with alpha lipoic acid (TCALA, n = 12), biolimus A9-eluting stents with biodegradable polymer (BES, n = 12), and TiO2 film-coated stent (TCstent, n = 12). Histopathologic analysis was performed at 28 days after stenting.


RESULTS
There was no significant difference in the injury score and internal elastic lamina (IEL) among the four groups. There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2.7 ± 1.0mm(2), 2.6 ± 0.94 mm(2), 48.9 ± 16.25%, 1.0 (range 0.0-3.0), 1.0 (range 0.0-2.0) in TCA stent group vs. 2.7 ± 1.24 mm(2), 2.9 ± 0.83 mm(2), 53.5 ± 17.19%, 1.0 (range 0.0-2.0), 1.0 (range 0.0-2.0) in TCALA stent group vs. 2.7 ± 1.30 mm(2), 2.6 ± 1.06 mm(2), 50.1 ± 23.20%, 2.0 (range 1.0-3.0), 2.0 (range 1.0-3.0) in BES group vs. 1.7 ± 0.63 mm(2), 3.3 ± 0.58 mm(2), 60.2 ± 10.12%, 0.5 (range 0.0-2.0), 1.0 (range 0.0-2.0) in TC stent group, respectively].


CONCLUSIONS
TCA and TCALA are more effective to reduce neointimal hyperplasia compared to TC. Moreover, fibrin and inflammation scores are significantly lower in TCA and TCALA than BES in porcine coronary restenosis model.
Korea Cardiovascular Stent Institute, Jangsung, Republic of Korea; Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Kyung Seob
KS
Lim
Korea Cardiovascular Stent Institute, Jangsung, Republic of Korea; Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea; Regeneromics Research Center, Chonnam National University, Gwangju, Republic of Korea. Electronic address: myungho@chollian.net.
Myung Ho
MH
Jeong
Korea Cardiovascular Stent Institute, Jangsung, Republic of Korea; Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea.
In Ho
IH
Bae
Korea Cardiovascular Stent Institute, Jangsung, Republic of Korea; Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea.
Jun-Kyu
JK
Park
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Dae Sung
DS
Park
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Jong Min
JM
Kim
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Jung Ha
JH
Kim
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Hyung-Seok
HS
Kim
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Yong Sook
YS
Kim
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Hye-Yun
HY
Jeong
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Sun-Jung
SJ
Song
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Eun Ju
EJ
Yang
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Dong Lyun
DL
Cho
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Doo Sun
DS
Sim
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Keun-Ho
KH
Park
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Young Joon
YJ
Hong
Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
Youngkeun
Y
Ahn
D000077284:Abciximab; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D023903:Coronary Restenosis / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D054855:Drug-Eluting Stents; D005337:Fibrin; D006965:Hyperplasia / Q000517:prevention & control; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D007249:Inflammation; D008297:Male; D058426:Neointima / Q000517:prevention & control; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011108:Polymers; D013552:Swine; D008063:Thioctic Acid / Q000008:administration & dosage*; D013997:Time Factors; D014025:Titanium; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D011108:Polymers; C009495:titanium dioxide; D008063:Thioctic Acid; D005337:Fibrin; D014025:Titanium; D000077284:Abciximab
Inflammation; Percutaneous coronary intervention; Restenosis; Stents