In situ forming implants for periodontitis treatment with improved adhesive properties.
Novel in situ forming implants are presented showing a promising potential to overcome one of the major practical hurdles associated with local periodontitis treatment: limited adhesion to the surrounding tissue, resulting in accidental expulsion of at least parts of the implants from the patients' pockets. This leads to high uncertainties in the systems' residence times at the site of action and in the resulting drug exposure. In the present study, the addition of different types and amounts of plasticizers (acetyltributyl citrate and dibutyl sebacate) as well as of adhesive polymers (e.g., cellulose derivatives such as hydroxypropyl methylcellulose) is shown to allow for a significant increase in the stickiness of poly(lactic-co-glycolic acid)-based implants. The systems are formed in situ from N-methyl pyrrolidone-based liquid formulations. Importantly, at the same time, good plastic deformability of the implants can be provided and desired drug release patterns can be fine-tuned using several formulation tools. The antimicrobial activity of this new type of in situ forming implants, loaded with doxycycline hyclate, was demonstrated using the agar well diffusion method and multiple Streptococcus strains isolated from the oral microflora of patients suffering from periodontitis.
University of Lille, College of Pharmacy, Lille, France; INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
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Do
University of Lille, College of Pharmacy, Lille, France; INSERM U 995, Inflammatory Bowel Diseases, Lille, France.
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Neut
INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France; University of Lille, School of Dentistry, Lille, France.
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Delcourt
University of Lille, College of Pharmacy, Lille, France; INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
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Seixas Certo
University of Lille, College of Pharmacy, Lille, France; INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
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Siepmann
University of Lille, College of Pharmacy, Lille, France; INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France. Electronic address: florence.siepmann@univ-lille2.fr.
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Siepmann
D000269:Adhesives / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015921:Dental Implants; D006801:Humans; D010518:Periodontitis / Q000601:surgery*; D010599:Pharmacokinetics; D010968:Plasticizers; D011108:Polymers / Q000737:chemistry
D000269:Adhesives; D000900:Anti-Bacterial Agents; D015921:Dental Implants; D010968:Plasticizers; D011108:Polymers
Bioadhesion; Doxycycline; In situ forming implant; Local drug delivery; PLGA; Periodontitis