Design, synthesis and characterization of zinc-morin, a metal flavonol complex and evaluation of its antidiabetic potential in HFD-STZ induced type 2 diabetes in rats.
The present study deals with the synthesis, characterization of zinc-morin complex and evaluation of its antidiabetic efficacy in High Fat Diet (HFD)-fedStreptozotocin (STZ) induced diabetic rats. Oral administration of zinc-morin complex to diabetic rats (5mg/kg body weight/day) for a period of 30 days resulted in the decreased levels of blood glucose and HbA1c. Oral administrations of the zinc-morin complex for 30 days significantly improved hyperglycemia, glucose intolerance, and insulin resistance. The elevated levels of lipid peroxides declined and the antioxidant competence was found to be improved in diabetic rats treated with the complex. The status of the lipid and lipoprotein profile in the serum was normalized upon treatment. Levels of TNFα decreased upon treatment with the complex. The altered levels of adipokines such as adiponectin and leptin were normalized upon treatment with the complex. In conclusion, the present study indicates that the zinc-morin complex possesses antidiabetic, antidyslipidemic and antioxidant potentials in HFD-fedSTZ induced diabetic rats.
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
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Sendrayaperumal
Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
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Iyyam Pillai
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India. Electronic address: subbus2020@yahoo.co.in.
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Subramanian
D052242:Adiponectin / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D056831:Coordination Complexes / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011897:Random Allocation; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*; D047309:Flavones
D052242:Adiponectin; D001786:Blood Glucose; D056831:Coordination Complexes; D005419:Flavonoids; D006442:Glycated Hemoglobin; D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D015032:Zinc; C008548:morin; D047309:Flavones
Antidiabetic; Antidyslipidemic; Antioxidant; High fat; Insulin resistance; Zinc–Morin