α-Glucosidase inhibitors from the stems of Embelia ribes.
From the ethyl acetate extract of the stems of Embelia ribes (Myrsinaceae), a new alkenylresorcinol, embeliphenol A (1), together with 11 known compounds have been isolated. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, except for 2 and 9. Compounds 1, 3-6, 8, and 12 showed more potent inhibitory activity, with IC50 values ranging from 10.4 to 116.7 μM, than that of a positive control acarbose (IC50 , 214.5 μM).
Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Vietnam.
Phu Hoang
PH
Dang
Hai Xuan
HX
Nguyen
Nhan Trung
NT
Nguyen
Hanh Ngoc Thi
HN
Le
Mai Thanh Thi
MT
Nguyen
D031645:Embelia / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry* / Q000302:isolation & purification
D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D012118:Resorcinols; C000595096:embeliphenol A
Embelia ribes; embeliphenol A; α-glucosidase inhibition