Selenium-platinum coordination compounds as novel anticancer drugs: selectively killing cancer cells via a reactive oxygen species (ROS)-mediated apoptosis route.
We report the preparation of selenium-containing platinum-based anticancer drug EG-Se/Pt. EG-Se/Pt was obtained from the coordination of selenium-containing molecules (EG-Se) with cisplatin (CDDP). The structure of EG-Se/Pt was characterized by (1) H and (77) Se NMR spectroscopy, XPS, ESI-MS, and MALDI-TOF. In aqueous solution, EG-Se/Pt self-assembles to form spherical aggregates. EG-Se/Pt shows enhanced stability against dilution and high salt concentration compared with EG-Se. EG-Se/Pt induces cell apoptosis via reactive oxygen species (ROS), which leads to high selectivity between cancer cells and normal cells in cytotoxicity assays. More importantly, EG-Se/Pt effectively inhibits tumor growth in vivo in tumor-bearing mice. It is anticipated that tuning the ROS level through the assembly of selenium-containing molecules can be a general method to realize anticancer selectivity.
Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084 (China).
Lingwu
L
Zeng
Yang
Y
Li
Tianyu
T
Li
Wei
W
Cao
Yu
Y
Yi
Weijia
W
Geng
Zhiwei
Z
Sun
Huaping
H
Xu
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D010984:Platinum / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012643:Selenium / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D010984:Platinum; D012643:Selenium
antitumor agents; cancer; coordination chemistry; reactive oxygen species; selenium