22 again: IL-22 as a risk gene and important mediator in psoriasis.
IL-22 targets our external epithelial barriers, bolstering our defenses, and has long been implicated in the pathogenesis of psoriasis. Nikamo and colleagues (2014) identify a haplotype in the IL22 promoter with a strong association to juvenile-onset psoriasis and demonstrate that this risk variant is associated with increased IL-22 production by T cells. We explore the implications of this work.
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Andrew
A
Johnston
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: johanng@med.umich.edu.
Johann E
JE
Gudjonsson
D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D011401:Promoter Regions, Genetic; D011565:Psoriasis / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D000097043:Interleukin-22
D007378:Interleukins; D000097043:Interleukin-22