Synthesis and evaluation of flavanones as anticancer agents.
A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol-water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (MCF7), human colon adenocarcinoma (HT29) and human kidney adenocarcinoma (A498) using sulforhodamine B dye. Results indicated that most of the compounds exhibited significant in vitro anticancer potential. Among them, compound having furan ring showed most potent activity against all the tested cell lines.
Institute of Pharmaceutical Research, GLA University, N.H.#2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406, India.
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Murti
Institute of Pharmaceutical Research, GLA University, N.H.#2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406, India.
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Mishra
A498; Flavanone; HT29; MCF7; SRB dye; anticancer activity; chalcone