Investigation of the central and peripheral analgesic and anti-inflammatory activity of Draksharishta an Indian Ayurvedic formulation.
BACKGROUND
Draksharishta (DRK) is an Ayurvedic formulation approved by the "National formulary of Ayurvedic Medicine 2011", of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. But there are very scientific evidences available to support their common uses.


OBJECTIVE
Our present studies make an attempt toward identifying probable antinociceptive and anti-inflammatory effect and its mechanisms of DRK.


RESULTS
DRK, at three doses, (10 mL/kg, 20 mL/kg, and 40 mL/kg) showed no involvement of the CNS in antinociceptive activity of the test drug. Both Carrageenan-induced paw edema and acetic acid writhing tests gave significant results (P < 0.05), indicating possible peripheral analgesic and anti-inflammatory action. Formalin-induced paw- licking test showed that DRK had significant effect in suppressing inflammatory pain (P < 0.05) but not neurogenic pain.


CONCLUSIONS
Hence our study shows anti-inflammatory and peripheral analgesic action for DRK.
Department of Pharmacy, North South University, Dhaka, Bangladesh.
Ashraf-Ul
AU
Kabir
Department of Pharmacy, North South University, Dhaka, Bangladesh.
Mehdi Bin
MB
Samad
Department of Pharmacy, North South University, Dhaka, Bangladesh.
Ninadh Malrina
NM
D Costa
Department of Pharmacy, North South University, Dhaka, Bangladesh.
Juardar Mohammad
JM
Hannan
Anti-inflammatory; Draksharishta; anti-nociceptive; central analgesic; peripheral analgesic