Mini gamma cameras for intra-operative nuclear tomographic reconstruction.
Nuclear imaging modalities like PET or SPECT are in extensive use in medical diagnostics. In a move towards personalized therapy, we present a flexible nuclear tomographic imaging system to enable intra-operative SPECT-like 3D imaging. The system consists of a miniaturized gamma camera mounted on a robot arm for flexible positioning, while spatio-temporal localization is provided by an optical tracking system. To facilitate statistical tomographic reconstruction of the radiotracer distribution using a maximum likelihood approach, a precise model of the mini gamma camera is generated by measurements. The entire system is evaluated in a series of experiments using a hot spot phantom, with a focus on criteria relevant for the intra-operative workflow, namely the number of required imaging positions as well as the required imaging time. The results show that high quality reconstructed images of simple hot spot configurations with positional errors of less than one millimeter are possible within acquisition times as short as 15s.
Computer Aided Medical Procedures (CAMP), Technische Universität München, Boltzmannstraße 3, 85748 Garching b. München, Germany. Electronic address: matthies@in.tum.de.
Philipp
P
Matthies
Computer Aided Medical Procedures (CAMP), Technische Universität München, Boltzmannstraße 3, 85748 Garching b. München, Germany; Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 München, Germany. Electronic address: gardiaza@in.tum.de.
José
J
Gardiazabal
Computer Aided Medical Procedures (CAMP), Technische Universität München, Boltzmannstraße 3, 85748 Garching b. München, Germany; Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 München, Germany.
Aslı
A
Okur
Computer Aided Medical Procedures (CAMP), Technische Universität München, Boltzmannstraße 3, 85748 Garching b. München, Germany.
Jakob
J
Vogel
Computer Aided Medical Procedures (CAMP), Technische Universität München, Boltzmannstraße 3, 85748 Garching b. München, Germany.
Tobias
T
Lasser
Computer Aided Medical Procedures (CAMP), Technische Universität München, Boltzmannstraße 3, 85748 Garching b. München, Germany.
Nassir
N
Navab
D004867:Equipment Design; D019544:Equipment Failure Analysis; D015902:Gamma Cameras; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D008904:Miniaturization; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*
Image reconstruction (iterative); Intra-operative imaging; Nuclear imaging