Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus.
OBJECTIVE
Discordant results about the relationship between diabetes complications and the risk of fragility fractures have been reported. Our aims were to analyze the factors related to morphometric vertebral fractures (VFs) in patients with type 2 diabetes mellitus, and to explore the association between the presence of VFs and the main cardiovascular risk factors.


METHODS
We carried out a cross-sectional study including 123 patients with type 2 diabetes mellitus, and in 72 of these patients we recorded data about the risk factors for VFs and comorbidities of diabetes including diabetes-related microvascular disease and cardiovascular disease.


RESULTS
In the crude analysis, diabetic retinopathy (odds ratio [OR] 4.09, 95% confidence interval [CI] 1.01-12.5), ischemic heart disease (OR 5.02, 95% CI 1.1-9.7) and waist circumference (OR 1.06, 95% CI 1.006-1.114) were related to VFs. In the full model (adjusted for age, sex, body mass index), ischemic heart disease was the only determinant of VF (OR 3.33, CI 1.02-10.91, P = 0.047); whereas diabetic retinopathy did not reached significance (OR 2.27, CI 0.71-7.27, P = 0.16).


CONCLUSIONS
In summary, ischemic heart disease is associated with an increased risk of VFs in type 2 diabetes mellitus.
Bone Metabolic Unit (RETICEF) Endocrinology Division Spain.
Manuel
M
Muñoz-Torres
Bone Metabolic Unit (RETICEF) Endocrinology Division Spain.
Rebeca
R
Reyes-García
Bone Metabolic Unit (RETICEF) Endocrinology Division Spain.
Antonia
A
García-Martin
Department of Preventive Medicine and Public Health University of Granada Epidemiology and Health Public CIBER (CIBERESP) Spain.
José Juan
JJ
Jiménez-Moleón
Bio-Health Research Foundation of Eastern Andalusia - Alejandro Otero (FIBAO) Granada Spain.
Amanda Rocío
AR
Gonzalez-Ramírez
Vascular Surgery Division University Hospital San Cecilio Spain.
María Jesús
MJ
Lara-Villoslada
Bone Metabolic Unit (RETICEF) Endocrinology Division Spain ; Endocrinology Division General Hospital of Ciudad Real Ciudad Real Spain.
Pedro Rozas
PR
Moreno
Ischemic heart disease; Type 2 diabetes mellitus; Vertebral fractures