Changes in intracellular potentials of snail neurons induced by β-phenylglutamic acid hydrochloride.
β-Phenylglutamic acid hydrochloride (RGPU-135, neuroglutamine, or glutarone) in concentrations of 1, 10, 100, and 1000 μM reversibly and dose-dependently modulated the intracellular action potentials in Plantorbarius corneus snail neurons and hyperpolarized the membrane by 9.1±2.5% with maximum shift of resting potential at 100 μM. Hyperpolarization was accompanied by up-regulation of synaptic activity and changes in the pattern of impulse activity manifested by a decrease in the discharge rate, shortening of the interburst time, increase in the mean number of spikes in the bursts, and shortening of the interspike time within the bursts. Both hyperpolarization and impulse activity rearrangement persisted for 10-20 min after washing of RGPU-135.
I. P. Pavlov St. Petersburg State Medical University, St. Petersburg, Russia, vislobokov@yandex.ru.
A I
AI
Vislobokov
Yu D
YD
Ignatov
V V
VV
Bagmetova
I N
IN
Tyurenkov
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology*; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008564:Membrane Potentials / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D012908:Snails / Q000502:physiology*
C581791:RGPU-135; D018698:Glutamic Acid