Expression of Bmi-1 and PAI-1 in esophageal squamous cell carcinoma.
OBJECTIVE
To determine the correlation between invasiveness, migration and prognosis in esophageal squamous cell carcinoma (ESCC) and expression of the B-cell-specific Moloney leukemia virus insert site 1 (Bmi-1) and plasminogen activator inhibitor-1 (PAI-1).


METHODS
Eighty previously untreated patients who underwent surgical excision of ESCC were included. The expression of Bmi-1 and PAI-1 was examined immunohistochemically in formalin-fixed paraffin-embedded primary tissue specimens. The relationships between the expression of Bmi-1 and PAI-1, the clinicopathologic features of ESCC, and the survival rate of ESCC patients were also discussed. The correlation between Bmi-1 and PAI-1 protein expression in ESCC was analyzed. The relationship between Bmi-1 and PAI-1 expression and ESCC prognosis was evaluated using a Cox regression model and Kaplan-Meier survival curve analysis.


RESULTS
The rates of positive Bmi-1 and PAI-1 expression in ESCC were higher than those in normal esophageal tissue (P < 0.05). The expression of Bmi-1 and PAI-1 was correlated with depth of invasion and lymph node metastasis (P < 0.05), but not with patient age, tumor size or nationality (P > 0.05). The expression of Bmi-1 was positively correlated with that of PAI-1 (P < 0.05). The 10-year overall survival rate for all patients was 20% (16/80). Univariate Kaplan-Meier survival analysis showed that patients with high expression of esophageal PAI-1 and Bmi-1 had lower survival, however, the difference was not statistically significant. Cox multivariate analysis showed that PAI-1 and Bmi-1 were not independent factors for survival rate, while the depth of tumor invasion and metastasis were independent factors affecting patient survival.


CONCLUSIONS
The expression of Bmi-1 and PAI-1 plays a role in ESCC progression, and may be used as a prognostic marker in ESCC.
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Yan
Y
Zhang
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Ya-Lou
YL
Zhang
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Hong-Ming
HM
Chen
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Hong-Wei
HW
Pu
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Wen-Jing
WJ
Ma
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Xiao-Mei
XM
Li
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Hong
H
Ma
Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Wen-Jing Ma, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
Xiao
X
Chen
D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D063150:Polycomb Repressive Complex 1 / Q000032:analysis*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors
C069077:BMI1 protein, human; D014408:Biomarkers, Tumor; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D063150:Polycomb Repressive Complex 1
B-cell-specific moloney leukemia virus insert site 1; Esophageal squamous cell carcinoma; Metastasis; Plasminogen activator inhibitor-1; Prognosis