Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery.
In this study, we report the novel double pH-sensitive mixed micelles to fabricate multicore niosomes for drug delivery. The double pH-sensitive mixed micelles (PMM) were prepared with different pH-sensitive polymers, mPEG2000-Hz-CHEMS and mPEG2000-IS (2:1 w/w). Ginsenoside Rh2-loaded DPMM was mixed with Pluronic F-68, in the aqueous medium, and multicore niosomes were fabricated. The size of multicore niosomes were around 100-300 nm with a high encapsulation efficiency of G-Rh2. The G-Rh2-MCN could release encapsulated G-Rh2 with an accelerated rate under lower pH conditions with lower cytotoxicity and good antitumor efficacy.
School of Pharmacy, Yantai University , Yantai , P. R. China.
Daquan
D
Chen
Hongyun
H
Yu
Hongjie
H
Mu
Guisheng
G
Li
Yan
Y
Shen
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D065546:Drug Liberation; D004355:Drug Stability; D036145:Ginsenosides / Q000008:administration & dosage* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D061986:MCF-7 Cells; D051379:Mice; D008823:Micelles; D011108:Polymers / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D036145:Ginsenosides; D008081:Liposomes; D008823:Micelles; D011108:Polymers; C055305:ginsenoside Rh2
Ginsenoside Rh2 delivery; double pH-sensitive; mixed micelles; multicore niosomes