Effect of Gd-EOB-DTPA on hepatic fat quantification using high-speed T2-corrected multi-echo acquisition in (1)H MR spectroscopy.
OBJECTIVE
To determine whether gadolinium ethoxybenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration affects hepatic fat quantification by magnetic resonance spectroscopy (MRS) using the fast breath-hold high-speed T2-corrected multiecho (HISTO) technique.


METHODS
Seventy-six patients underwent Gd-EOB-DTPA-enhanced liver MR and 15sec breath-hold HISTO MRS (4 times), twice before and twice after Gd-EOB-DTPA administration. Two consecutive MRSs were performed immediately before the dynamic study. Post-contrast MRS was performed twice continuously, approximately 15min after contrast injection, prior to obtaining 20-min hepatobiliary phase images. We used paired t-test and intraclass correlation coefficient (ICC) to evaluate the variability of the mean fat fraction (FF) on pre-contrast MRS and post-contrast MRS and the effect of the contrast agent on the mean FF.


RESULTS
The mean FFs were not significantly different between pre-contrast MRS and post-contrast MRS (6.50%±6.54 versus 6.70%±6.61, P=0.15). The ICC of FF calculation between pre- and post-contrast MRS was 0.984. The ICCs for the FF magnitude between pre- and post-contrast MRS were 0.452, 0.771, and 0.995 for FF <5%, FF 5-10%, and FF ≥10%, respectively.


CONCLUSIONS
Gd-EOB-DTPA does not appear to influence hepatic fat quantification, especially for patients with hepatic steatosis.
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Yang Shin
YS
Park
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. Electronic address: chlee86@korea.ac.kr.
Chang Hee
CH
Lee
Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Ji Hoon
JH
Kim
Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Baek Hui
BH
Kim
Department of Radiology, Ewha Womans University Mokdong Hospital, Seoul, Korea.
Jeoung Hyun
JH
Kim
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Kyeong Ah
KA
Kim
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Cheol Min
CM
Park
D000273:Adipose Tissue / Q000737:chemistry*; D050154:Adiposity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D003287:Contrast Media / Q000493:pharmacokinetics; D005234:Fatty Liver / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015415:Biomarkers; D003287:Contrast Media; D008055:Lipids; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
Fatty liver; High-speed T2-corrected multi-echo; Liver; MR spectroscopy; MRI