Carboxymethyl-cellulose/Fe3O4 nanostructures for antimicrobial substances delivery.
The synthesis of carboxymethyl-cellulose/magnetite (CMC/Fe3O4) was carried out. This magnetic hybrid material was characterized by infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. The adsorption of norfloxacin and cefotaxim antimicrobial substances (ATB) onto the CMC/Fe3O4 was performed in order to investigate the capacity of the magnetic scaffold to improve the antimicrobial activity of the respective therapeutic agents, assessed by an in vitro quantitative assay. The obtained results proved that CMC/Fe3O4/ATBs might be a promising candidate for the development of efficient and cheap antimicrobial drugs carriers under magnetic field.
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania.
Mihaela
M
Vlad
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania.
Ecaterina
E
Andronescu
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania.
Alexandru Mihai
AM
Grumezescu
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania.
Anton
A
Ficai
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania.
Georgeta
G
Voicu
S. Nicolau Institute of Virology, Bucharest, Romania.
Coralia
C
Bleotu
Microbiology Department, Faculty of Biology, University of Bucharest, Bucharest, Romania.
Mariana Carmen
MC
Chifiriuc
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry* / Q000494:pharmacology; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008280:Magnetics; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D049329:Nanostructures / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000890:Anti-Infective Agents; D004337:Drug Carriers; D002266:Carboxymethylcellulose Sodium; D052203:Ferrosoferric Oxide
CMC/Fe3O4; antimicrobial activity; biocompatibility; drug delivery; magnetic scaffold