Formation of four different aromatic scaffolds from nitriles through tandem divergent catalysis.
A zinc bromide complex, formed by the sequential reaction of nitriles with a Reformatsky reagent and terminal alkynes, is used as an intermediate for divergent palladium-catalyzed reactions. The reaction pathway of the intermediate is precisely controlled by the choice of the reaction solvent or the palladium catalyst to quickly form four different aromatic scaffolds--arylamines, aminoindenes, pyrroles, and quinolines--starting from readily available nitriles.
Department of Chemistry and Nano Science (BK 21 plus), Ewha Womans University, Seoul 120-750 (Korea).
Ju Hyun
JH
Kim
Jean
J
Bouffard
Sang-gi
SG
Lee
D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
D001965:Bromides; D009570:Nitriles; D017967:Zinc Compounds; D010165:Palladium; C093802:zinc bromide
aromatics; divergency; nitriles; palladium; tandem reactions