The pleiotropic roles of sphingolipid signaling in autophagy.
The autophagic process involves encompassing damaged proteins and organelles within double- or multi-membraned structures and delivering these molecules to the lytic compartments of vacuoles. Sphingolipids (SLs), which are ubiquitous membrane lipids in eukaryotes, participate in the generation of various membrane structures, including rafts, caveolae, and cytosolic vesicles. SLs are a complex family of molecules that have a growing number of members, including ceramide, sphingosine-1-phosphate, and dihydroceramide, which have been associated with the essential cellular process of autophagy. This review highlights recent studies focusing on the regulation and function of SL-associated autophagy and its role in cell fate, diseases, and therapeutic interventions.
1] The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032, China [2] Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Y
Y
Li
1] The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032, China [2] Department of Oral Biology, Stomatology School, The Fourth Military Medical University, Xi'an 710032, China.
S
S
Li
Department of Chemistry, Pharmacy School, The Fourth Military Medical University, Xi'an 710032, China.
X
X
Qin
Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
W
W
Hou
Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
H
H
Dong
The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032, China.
L
L
Yao
Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
L
L
Xiong
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D001343:Autophagy / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D013107:Sphingolipids / Q000378:metabolism*
D000970:Antineoplastic Agents; D013107:Sphingolipids