Hepatocellular carcinoma: genome-scale metabolic models for hepatocellular carcinoma.
A new study proposes a modelling strategy to identify reactions, genes and metabolites relevant in hepatocellular carcinoma using in silico and in vivo analyses. The proposed genome-scale metabolic model integrates genomic and proteomic information, and points to statins, among others, as potential chemopreventive and anticancer drugs.
HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Rosselló 153, 08036 Barcelona, Spain.
Roser
R
Pinyol
HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Rosselló 153, 08036 Barcelona, Spain.
Josep M
JM
Llovet
D000465:Algorithms; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D016678:Genome; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D008962:Models, Theoretical