Ion chromatography as highly suitable method for rapid and accurate determination of antibiotic fosfomycin in pharmaceutical wastewater.
A rapid and accurate ion chromatography (IC) method (limit of detection as low as 0.06 mg L(-1)) for fosfomycin concentration determination in pharmaceutical industrial wastewater was developed. This method was compared with the performance of high performance liquid chromatography determination (with a high detection limit of 96.0 mg L(-1)) and ultraviolet spectrometry after reacting with alizarin (difficult to perform in colored solutions). The accuracy of the IC method was established in the linear range of 1.0-15.0 mg L(-1) and a linear correlation was found with a correlation coefficient of 0.9998. The recoveries of fosfomycin from industrial pharmaceutical wastewater at spiking concentrations of 2.0, 5.0 and 8.0 mg L(-1) ranged from 81.91 to 94.74%, with a relative standard deviation (RSD) from 1 to 4%. The recoveries of effluent from a sequencing batch reactor treated fosfomycin with activated sludge at spiking concentrations of 5.0, 8.0, 10.0 mg L(-1) ranging from 98.25 to 99.91%, with a RSD from 1 to 2%. The developed IC procedure provided a rapid, reliable and sensitive method for the determination of fosfomycin concentration in industrial pharmaceutical wastewater and samples containing complex components.
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China E-mail: songyh@craes.org.cn; Department of Urban Water Environmental Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Ping
P
Zeng
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China E-mail: songyh@craes.org.cn; Department of Urban Water Environmental Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Xiaolin
X
Xie
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China E-mail: songyh@craes.org.cn; Department of Urban Water Environmental Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Yonghui
Y
Song
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China E-mail: songyh@craes.org.cn; Department of Urban Water Environmental Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Ruixia
R
Liu
Department of Urban Water Environmental Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Chaowei
C
Zhu
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, ENSCM, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France.
Anne
A
Galarneau
Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés, UMR 5504 INSA/CNRS, UMR 792 INSA/INRA, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France.
Jean-Stéphane
JS
Pic
D000880:Anthraquinones; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002845:Chromatography / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004345:Drug Industry; D004784:Environmental Monitoring; D005578:Fosfomycin / Q000737:chemistry*; D007220:Industrial Waste / Q000032:analysis; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000737:chemistry*
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D007220:Industrial Waste; D014874:Water Pollutants, Chemical; D005578:Fosfomycin; C010078:alizarin