Improving intra-fractional target position accuracy using a 3D surface surrogate for left breast irradiation using the respiratory-gated deep-inspiration breath-hold technique.
OBJECTIVE
To evaluate the use of 3D optical surface imaging as a surrogate for respiratory gated deep-inspiration breath-hold (DIBH) for left breast irradiation.


METHODS
Patients with left-sided breast cancer treated with lumpectomy or mastectomy were selected as candidates for DIBH treatment for their external beam radiation therapy. Treatment plans were created on both free breathing (FB) and DIBH computed tomography (CT) simulation scans to determine dosimetric benefits from DIBH. The Real-time Position Management (RPM) system was used to acquire patient's breathing trace during DIBH CT acquisition and treatment delivery. The reference 3D surface models from FB and DIBH CT scans were generated and transferred to the "AlignRT" system for patient positioning and real-time treatment monitoring. MV Cine images were acquired during treatment for each beam as quality assurance for intra-fractional position verification. The chest wall excursions measured on these images were used to define the actual target position during treatment, and to investigate the accuracy and reproducibility of RPM and AlignRT.


RESULTS
Reduction in heart dose can be achieved using DIBH for left breast/chest wall radiation. RPM was shown to have inferior correlation with the actual target position, as determined by the MV Cine imaging. Therefore, RPM alone may not be an adequate surrogate in defining the breath-hold level. Alternatively, the AlignRT surface imaging demonstrated a superior correlation with the actual target positioning during DIBH. Both the vertical and magnitude real-time deltas (RTDs) reported by AlignRT can be used as the gating parameter, with a recommended threshold of ±3 mm and 5 mm, respectively.


CONCLUSIONS
The RPM system alone may not be sufficient for the required level of accuracy in left-sided breast/CW DIBH treatments. The 3D surface imaging can be used to ensure patient setup and monitor inter- and intra- fractional motions. Furthermore, the target position accuracy during DIBH treatment can be improved by AlignRT as a superior surrogate, in addition to the RPM system.
Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, Ohio, United States of America.
Yi
Y
Rong
Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, Ohio, United States of America.
Steve
S
Walston
Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, Ohio, United States of America.
Meng Xu
MX
Welliver
Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, Ohio, United States of America.
Arnab
A
Chakravarti
Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, Ohio, United States of America.
Allison M
AM
Quick
D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D062485:Breath Holding; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D012119:Respiration; D014057:Tomography, X-Ray Computed