[Hedgehog signaling pathway and osteoporosis].
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis.
Ming
M
Luo
Hong-Xing
HX
Huang
Hong
H
Huang
Ze-Tian
ZT
Li
Yuan-Yuan
YY
Lai
D002454:Cell Differentiation; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics / Q000502:physiology; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D010006:Osteoblasts / Q000166:cytology; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology*; D015398:Signal Transduction / Q000502:physiology*; D000076182:Sp7 Transcription Factor; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D050659:Core Binding Factor Alpha 1 Subunit; D053823:Hedgehog Proteins; D000076182:Sp7 Transcription Factor; C478163:SP7 protein, human; D014157:Transcription Factors