Zinc mediated allylations of chlorosilanes promoted by ultrasound: synthesis of novel constrained sila amino acids.
A simple, fast and efficient method for allylation and propargylation of chlorosilanes through zinc mediation and ultrasound promotion is reported. As a direct application of the resulting bis-allylsilanes, three novel, constrained sila amino acids are prepared for the first time. The design and synthesis of the constrained sila analogue of GABA (γ-amino butyric acid) is a highlight of this work.
Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr HomiBhabha Road, Pune, 411008, India. ds.reddy@ncl.res.in.
Remya
R
Ramesh
D Srinivasa
DS
Reddy
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D014465:Ultrasonics / Q000379:methods*; D015032:Zinc / Q000737:chemistry*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis
D000596:Amino Acids; D012821:Silanes; D005680:gamma-Aminobutyric Acid; D015032:Zinc; D012825:Silicon