A polymer-based ratiometric intracellular glucose sensor.
The glucose metabolism level reflects cell proliferative status. A polymeric glucose ratiometric sensor comprising poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMAETMA) was synthesized. Cellular internalization and glucose response of the polymer within HeLa cells were investigated.
Center for Biosignatures Discovery Automation, Biodesign Institute, Arizona State University, Tempe 85287-6501, USA. Yanqing.tian@asu.edu.
Liqiang
L
Zhang
Fengyu
F
Su
Sean
S
Buizer
Xiangxing
X
Kong
Fred
F
Lee
Kevin
K
Day
Yanqing
Y
Tian
Deirdre R
DR
Meldrum
D015374:Biosensing Techniques; D005453:Fluorescence; D005947:Glucose / Q000032:analysis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D011109:Polymethacrylic Acids / Q000737:chemistry*
D011109:Polymethacrylic Acids; C011533:Duxon; D005947:Glucose; D010100:Oxygen