Correlation of glycated albumin but not hemoglobin A1c with endogenous insulin secretion in fulminant type 1 diabetes mellitus.
Aims/Introduction:  Fulminant type 1 diabetes mellitus (FT1DM) develops as a result of very rapid and almost complete pancreatic β-cell destruction. We hypothesized that in patients with FT1DM who have less endogenous insulin secretion, disease progression is more rapid, and thus glycated albumin (GA) levels are lower. This study was designed to prove this hypothesis.


METHODS
The present study included 42 patients with FT1DM (24 men, 18 women) in whom glycated hemoglobin (HbA1c), GA and daily urinary C-peptide (CPR) were measured at the time of diagnosis. Patients with complications, such as liver disease, kidney disease, anemia, or who were pregnant were excluded.


RESULTS
Urinary CPR (log transformed) was not correlated with HbA1c (R = 0.168, P = 0.287), but was positively correlated with GA (R = 0.336, P = 0.030). It was weakly, but not significantly, correlated with GA/HbA1c ratio (R = 0.281, P = 0.072). In patients with GA < 24.0%, urinary CPR was significantly lower than in patients with GA ≥ 24.0%. In addition, in patients with GA/HbA1c ratio <3.8, urinary CPR was significantly lower than in patients with GA/HbA1c ratio ≥ 3.8.


CONCLUSIONS
Our findings suggest that in patients with FT1DM, GA at the time of diagnosis was correlated with endogenous insulin secretion. GA < 24.0% at the time of diagnosis is predictive for less endogenous insulin secretion in patients with FT1DM. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00050.x, 2010).
Department of Internal Medicine, Kinki Central Hospital, Hyogo.
Masafumi
M
Koga
Department of Internal Medicine, Kinki Central Hospital, Hyogo.
Jun
J
Murai
Department of Internal Medicine, Kinki Central Hospital, Hyogo.
Hiroshi
H
Saito
Department of Medicine, Nissay Hospital.
Soji
S
Kasayama
Third Department of Internal Medicine, University of Yamanashi School of Medicine, Yamanashi.
Tetsuro
T
Kobayashi
Department of Metabolic Medicine, Osaka University Graduate School of Medicine.
Akihisa
A
Imagawa
First Department of Internal Medicine, Osaka Medical College, Osaka, Japan.
Toshiaki
T
Hanafusa
C‐peptide; Fulminant type 1 diabetes mellitus; Glycated albumin