A model study for tethering of (bio)active molecules to biomaterial surfaces through arginine.
A new approach for tethering of bioactive molecules via arginine is proposed and validated on collagen 2D matrices. The method involves the introduction of a methyl ketone on arginine side-chains, followed by reaction with model alkoxyamino derivatives.
Pain Therapy Service, Fondazione IRCCS Policlinico San Matteo, via Golgi, 19-27100 Pavia, Italy.
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F
Taraballi
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Russo
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C
Battocchio
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G
Polzonetti
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F
Nicotra
L
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Cipolla
D000818:Animals; D001120:Arginine / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D019791:Guanidine / Q000737:chemistry; D006736:Horses; D007659:Ketones / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D011765:Pyruvaldehyde / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D001672:Biocompatible Materials; D007659:Ketones; D011765:Pyruvaldehyde; D003094:Collagen; D001120:Arginine; D007785:Lactose; D019791:Guanidine