Anisotropic conductivity tensor imaging in MREIT using directional diffusion rate of water molecules.
Magnetic resonance electrical impedance tomography (MREIT) is an emerging method to visualize electrical conductivity and/or current density images at low frequencies (below 1 KHz). Injecting currents into an imaging object, one component of the induced magnetic flux density is acquired using an MRI scanner for isotropic conductivity image reconstructions. Diffusion tensor MRI (DT-MRI) measures the intrinsic three-dimensional diffusion property of water molecules within a tissue. It characterizes the anisotropic water transport by the effective diffusion tensor. Combining the DT-MRI and MREIT techniques, we propose a novel direct method for absolute conductivity tensor image reconstructions based on a linear relationship between the water diffusion tensor and the electrical conductivity tensor. We first recover the projected current density, which is the best approximation of the internal current density one can obtain from the measured single component of the induced magnetic flux density. This enables us to estimate a scale factor between the diffusion tensor and the conductivity tensor. Combining these values at all pixels with the acquired diffusion tensor map, we can quantitatively recover the anisotropic conductivity tensor map. From numerical simulations and experimental verifications using a biological tissue phantom, we found that the new method overcomes the limitations of each method and successfully reconstructs both the direction and magnitude of the conductivity tensor for both the anisotropic and isotropic regions.
Department of Mathematics, Konkuk University, Seoul, Korea.
Oh In
OI
Kwon
Woo Chul
WC
Jeong
Saurav Z K
SZ
Sajib
Hyung Joong
HJ
Kim
Eung Je
EJ
Woo
D016880:Anisotropy; D004058:Diffusion; D017097:Electric Impedance; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D059629:Signal-To-Noise Ratio; D014054:Tomography / Q000379:methods*; D014867:Water / Q000378:metabolism*
D014867:Water