Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans.
Intense exercise is associated with a reduction in cerebral blood flow (CBF), but regulation of CBF during strenuous exercise in the heat with dehydration is unclear. We assessed internal (ICA) and common carotid artery (CCA) haemodynamics (indicative of CBF and extra-cranial blood flow), middle cerebral artery velocity (MCA Vmean), arterial-venous differences and blood temperature in 10 trained males during incremental cycling to exhaustion in the heat (35°C) in control, dehydrated and rehydrated states. Dehydration reduced body mass (75.8 ± 3 vs. 78.2 ± 3 kg), increased internal temperature (38.3 ± 0.1 vs. 36.8 ± 0.1°C), impaired exercise capacity (269 ± 11 vs. 336 ± 14 W), and lowered ICA and MCA Vmean by 12-23% without compromising CCA blood flow. During euhydrated incremental exercise on a separate day, however, exercise capacity and ICA, MCA Vmean and CCA dynamics were preserved. The fast decline in cerebral perfusion with dehydration was accompanied by increased O2 extraction (P < 0.05), resulting in a maintained cerebral metabolic rate for oxygen (CMRO2). In all conditions, reductions in ICA and MCA Vmean were associated with declining cerebral vascular conductance, increasing jugular venous noradrenaline, and falling arterial carbon dioxide tension (P aCO 2) (R(2) ≥ 0.41, P ≤ 0.01) whereas CCA flow and conductance were related to elevated blood temperature. In conclusion, dehydration accelerated the decline in CBF by decreasing P aCO 2 and enhancing vasoconstrictor activity. However, the circulatory strain on the human brain during maximal exercise does not compromise CMRO2 because of compensatory increases in O2 extraction.
Centre for Sports Medicine and Human Performance, Brunel University, London, UK.
Steven J
SJ
Trangmar
Centre for Sports Medicine and Human Performance, Brunel University, London, UK.
Scott T
ST
Chiesa
Centre for Sports Medicine and Human Performance, Brunel University, London, UK.
Christopher G
CG
Stock
Centre for Sports Medicine and Human Performance, Brunel University, London, UK.
Kameljit K
KK
Kalsi
Centre for Sports Medicine and Human Performance, Brunel University, London, UK Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Niels H
NH
Secher
Centre for Sports Medicine and Human Performance, Brunel University, London, UK j.gonzalez-alonso@brunel.ac.uk.
José
J
González-Alonso
D000328:Adult; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D002339:Carotid Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003681:Dehydration / Q000378:metabolism / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000502:physiology; D010100:Oxygen / Q000502:physiology; D010101:Oxygen Consumption; D055815:Young Adult
D010100:Oxygen