I2-catalyzed oxidative cross-coupling of methyl ketones and benzamidines hydrochloride: a facile access to α-ketoimides.
An iodine-catalyzed oxidative cross-coupling of C-H/N-H has been demonstrated. This simple and efficient approach constructed α-ketoimides in good to excellent yields from methyl ketones and benzamidines hydrochloride under metal-free and peroxide-free conditions. This synthetic strategy was achieved via an in situ iodination-based oxidative coupling pathway.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
Xia
X
Wu
Qinghe
Q
Gao
Shan
S
Liu
Anxin
A
Wu
D001550:Benzamidines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006851:Hydrochloric Acid / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
D001550:Benzamidines; D007659:Ketones; D007455:Iodine; C032157:benzamidine; D006851:Hydrochloric Acid