The role of BTB-zinc finger transcription factors during T cell development and in the regulation of T cell-mediated immunity.
The proper regulation of the development and function of peripheral helper and cytotoxic T cell lineages is essential for T cell-mediated adaptive immunity. Progress made during the last 10-15 years led to the identification of several transcription factors and transcription factor networks that control the development and function of T cell subsets. Among the transcription factors identified are also several members of the so-called BTB/POZ domain containing zinc finger (ZF) transcription factor family (BTB-ZF), and important roles of BTB-ZF factors have been described. In this review, we will provide an up-to-date overview about the role of BTB-ZF factors during T cell development and in peripheral T cells.
Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria, wilfried.ellmeier@meduniwien.ac.at.
Wilfried
W
Ellmeier
Ichiro
I
Taniuchi
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007109:Immunity; D038041:Lymphopoiesis; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016335:Zinc Fingers
D014157:Transcription Factors