Role of perifollicular Doppler blood flow in predicting cycle response in infertile women with genital tuberculosis undergoing in vitro fertilization/intracytoplasmic sperm injection.
OBJECTIVE
This study was evaluated the role of perifollicular Doppler blood flow in predicting cycle response in women with and without genital tuberculosis (TB) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles.


METHODS
This prospective observational study was performed on 254 women undergoing IVF for tubal factor infertility in the assisted reproductive unit. Perifollicular Doppler blood flows were assessed in dominant follicles >16 mm before oocyte recovery in patients with and without genital TB.


RESULTS
A positive correlation was found between estradiol on the day of human chorionic gonadotropin (r = 0.15, P = 0.05), number of oocytes retrieved (r = 0.25, P = 0.001), MII (r = 0.24, P = 0.001), day 1 2PN (r = 0.16, P = 0.04), number of embryos (r = 0.16, P = 0.04) and blood flow in patients without genital TB. A trend of having poor ovarian blood flow was observed in patients with genital TB when compared with those without the disease (P > 0.001).


CONCLUSIONS
In our study, the perifollicular blood flow (PFBF) provided a favorable prediction on the quantity of oocytes retrieved, MII, day 1 2PN and number of embryos but did not show any significant statistical difference in other outcome variables including fertilization or cleavage rate in women with or without genital TB undergoing IVF/ICSI cycles. Hence PFBF has the potential to be used as a simple and non-invasive surrogate marker of capillary blood flow around recruitable follicles to predict response to ovarian stimulation and cycle outcome.
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Neena
N
Malhotra
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Anupama
A
Bahadur
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Neeta
N
Singh
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Mani
M
Kalaivani
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Suneeta
S
Mittal
Doppler; genital tuberculosis; ovarian stimulation; perifollicular blood flow; surrogate marker