p53 keeps bystanders at the gates.
The inappropriate expansion of self-reactive "bystander" T cells can contribute to autoimmune disease. In this issue of Immunity, Watanabe et al. (2014) demonstrate that the tumor suppressor p53 prevents the cytokine-dependent proliferation of T cells in the absence of cognate antigens.
Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Michael A
MA
Fray
Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: stephen.bunnell@tufts.edu.
Stephen C
SC
Bunnell
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D016159:Tumor Suppressor Protein p53; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2