Association of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients.
Aims/Introduction:  Resistin, an inflammatory cytokine, might be involved in the development of atherosclerosis. In a recent paper, we showed that resistin polymorphism might be a risk marker for stroke susceptibility in Japanese type 2 diabetic patients. We tested whether the serum resistin levels might be also a risk marker of stroke independently from RETN polymorphism.


METHODS
Type 2 diabetic outpatients from our hospitals were enrolled. Patients (n = 89) with a history of coronary heart disease and stroke, and randomly selected controls (n = 178) matched for sex and age, but without a history of coronary heart disease and stroke, were examined for polymorphism -420 (C>G) and cytokines levels.


RESULTS
Serum resistin levels were significantly higher in patients with cardiovascular diseases (CVD) than in those without CVD (P = 0.024), and were highest in patients with stroke among the CVD. In multiple logistic regression analysis, serum resistin levels was an independent risk marker of stroke even after adjusted by RETN polymorphism, age, sex, body mass index, HbA1c, systolic and diastolic blood pressure, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, creatinine, history of coronary heart disease, treatment of insulin, sulfonylurea and aspirin (odds ratio 1.33, 95% confidence interval [CI] 1.02-1.73, P = 0.039). The enrolled patients were divided by their serum resistin levels (high or low group) and their genotypes (CC, CG, GG at -420) into six groups. Patients with the GG genotype and high resistin levels showed the highest odds ratio, 5.69 (95% CI 1.24-26.1), compared with the group with CC and low levels.


CONCLUSIONS
The results suggest that serum resistin levels might be a good marker of susceptibility to stroke as well as RETN polymorphism. (J Diabetes Invest, doi: 10.1111/j.2040-1124.00040.x, 2010).
Diabetes Center, Chubu Rosai Hospital, Japan Labour Health and Welfare Organization ; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Eitaro
E
Nakashima
Diabetes Center, Chubu Rosai Hospital, Japan Labour Health and Welfare Organization.
Atsuko
A
Watarai
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Takayoshi
T
Tsukahara
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Yoji
Y
Hamada
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Keiko
K
Naruse
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Hideki
H
Kamiya
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Jiro
J
Kato
Department of Gene Diagnostics and Therapeutics, International Medical Center of Japan, Tokyo.
Norihiro
N
Kato
Department of Mathematical Sciences, Faculty of Mathematical Sciences and Information Engineering, Nanzan University, Seto, Japan.
Makoto
M
Tomita
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Yutaka
Y
Oiso
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya.
Jiro
J
Nakamura
Resistin; Stroke; Type 2 diabetes