Measuring microangiopathy abnormalities in systemic sclerosis patients: the role of capillaroscopy-based scoring models.
Capillaroscopy is a noninvasive imaging technique for the in vivo study of microcirculation. The role of a qualitative evaluation of capillaroscopy in the assessment of Raynaud's phenomenon secondary to scleroderma spectrum disorder, particularly systemic sclerosis (SSc), is well defined. The usefulness of capillaroscopy in the follow-up of SSc patients and the possible prognostic role for the appearance of typical SSc vascular and visceral involvement, namely, digital ulcers, pulmonary arterial hypertension, and mortality, is suggested by many authors but still under debate. In this regard, and for a reliable and repeatable longitudinal evaluation of SSc microangiopathy, a quantitative analysis should be required. In this review, we describe the current classifications proposed to define the SSc microvascular involvement and the scoring methods suggested for a semiquantitative and quantitative analysis of microangiopathy and its correlation with clinical manifestations of disease.
Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
Marco
M
Sebastiani
Andreina
A
Manfredi
Giulia
G
Cassone
Dilia
D
Giuggioli
Cecilia
C
Ghizzoni
Clodoveo
C
Ferri
D006801:Humans; D008833:Microcirculation / Q000502:physiology; D020678:Microscopic Angioscopy / Q000592:standards*; D011859:Radiography; D012107:Research Design / Q000592:standards*; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging* / Q000503:physiopathology