Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides.
Diverse 4-aryl-2-quinolinones are prepared from propionamides in one pot by ligand-promoted triple sequential C-H activation reactions and a stereospecific Heck reaction. In these cascade reactions, three new C-C bonds and one C-N bond are formed to rapidly build molecular complexity from propionic acid.
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
Youqian
Y
Deng
Wei
W
Gong
Jian
J
He
Jin-Quan
JQ
Yu
D000577:Amides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D015363:Quinolones / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
D000577:Amides; D008024:Ligands; D015363:Quinolones; D012997:Solvents; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C034666:propionamide
C-H activation; amidation; arylation; dehydrogenation; quinolinone