A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
BACKGROUND
Recent studies show that enzymatically hydrolysed collagen, the collagen peptide, is absorbed and distributed to joint tissues and has analgesic and anti-inflammatory properties. A double-blind, placebo-controlled, randomised trial with collagen peptides isolated from pork skin (PCP) and bovine bone (BCP) sources was carried out to study the effectiveness of orally supplemented collagen peptide to control the progression of osteoarthritis in patients diagnosed with knee osteoarthritis. Improvement in treatment was assessed with reduction in Western Ontario McMaster Universities (WOMAC), visual analogue scale (VAS) and quality of life (QOL) scores from baseline to 13 weeks (Visit 7). Safety and tolerability were also evaluated.


RESULTS
There was significant reduction from baseline to Visit 7 in the primary end points of WOMAC and VAS scores and in the secondary end point of QOL score in subjects with PCP and BCP groups, while in subjects with placebo group the end point indices remained unaltered. Furthermore, all the score levels of WOMAC, VAS and QOL decreased significantly (P < 0.01) in the study group compared to placebo group in Visit 7.


CONCLUSIONS
The study demonstrated that collagen peptides are potential therapeutic agents as nutritional supplements for the management of osteoarthritis and maintenance of joint health.
Nitta Gelatin India Ltd, Kinfra Parks Ltd, Kakkanad, Cochin - 682030, India.
Suresh
S
Kumar
Fumihito
F
Sugihara
Keiji
K
Suzuki
Naoki
N
Inoue
Sriraam
S
Venkateswarathirukumara
D000328:Adult; D000368:Aged; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D001842:Bone and Bones / Q000737:chemistry; D002417:Cattle; D003094:Collagen / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000009:adverse effects; D019587:Dietary Supplements / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D010352:Patient Dropouts; D010446:Peptide Fragments / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D011788:Quality of Life; D012720:Severity of Illness Index; D012867:Skin / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010446:Peptide Fragments; D003094:Collagen
cartilage; clinical study; collagen peptide; osteoarthritis