Comparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome.
OBJECTIVE
Metabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS.


METHODS
Total of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 ± 10.4 in different offices in a city in Japan.


METHODS
Fasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion.


RESULTS
Serum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2'-deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2 in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, γ-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, γ-GT, HOMA-R in women under 50 years old.


CONCLUSIONS
Ferritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men.
Department of Public Health, Faculty of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Suketaka
S
Iwanaga
Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa, 761-0793, Japan.
Noriko
N
Sakano
Geriatric Health Service Facility, Niwanosato Home, Mihara, Hiroshima, 729-1321, Japan.
Kazuhisa
K
Taketa
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Noriko
N
Takahashi
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Da-Hong
DH
Wang
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Hidekazu
H
Takahashi
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Masayuki
M
Kubo
Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa, 761-0793, Japan.
Nobuyuki
N
Miyatake
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan. Electronic address:kogino@md.okayama-u.ac.jp.
Keiki
K
Ogino
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D008875:Middle Aged; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology
D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D005293:Ferritins