Catalytic asymmetric aminolactonization of 1,2-disubstituted alkenoic acid esters: efficient construction of aminolactones with an all-carbon quaternary stereo-centre.
Chiral BOX-Cu(OTf)2 catalyzed enantioselective aminolactonization of the tert-butyl ester of alkenoic acids has been developed via in situ aziridination using PhINNs as the nitrene source. It provides exclusively trans-γ- and δ-amino lactones including an additional all-carbon quaternary stereo-centre with up to 98% ee in good to excellent yields.
Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur 721302, India. shajra@chem.iitkgp.ernet.in.
Saumen
S
Hajra
Sk Md Samim
SM
Akhtar
Sk Mohammad
SM
Aziz