Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds.
Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.
Department of Chemistry, University College London, 20 Gordon St, London, UK. j.r.baker@ucl.ac.uk.
Cristina
C
Marculescu
Hanno
H
Kossen
Rachel E
RE
Morgan
Patrick
P
Mayer
Sally A
SA
Fletcher
Berend
B
Tolner
Kerry A
KA
Chester
Lyn H
LH
Jones
James R
JR
Baker
D003545:Cysteine / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D051380:GRB2 Adaptor Protein / Q000737:chemistry; D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry*; D013004:Somatostatin / Q000737:chemistry
D004220:Disulfides; D051380:GRB2 Adaptor Protein; D008301:Maleimides; D013004:Somatostatin; D003545:Cysteine