Functional activity of Th-17 lymphocytes in pulmonary tuberculosis.
Increased content of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia, kononova.te@gmail.com.
T E
TE
Kononova
O I
OI
Urazova
V V
VV
Novitskii
E G
EG
Churina
Yu V
YV
Kolobovnikova
M V
MV
Ignatov
P A
PA
Zakharova
O V
OV
Pechenova
D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D055815:Young Adult; D000097043:Interleukin-22
D015704:CD4 Antigens; D020381:Interleukin-17; D007378:Interleukins; D055651:NK Cell Lectin-Like Receptor Subfamily B; D000097043:Interleukin-22; C508717:IL17A protein, human; C527203:KLRB1 protein, human