Oncolytic virotherapy of canine and feline cancer.
Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer.
Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. ivaylo.gentschev@mail.uni-wuerzburg.de.
Ivaylo
I
Gentschev
Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. sandeep.patil@stud-mail.uni-wuerzburg.de.
Sandeep S
SS
Patil
Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. ivan.petrov@uni-wuerzburg.de.
Ivan
I
Petrov
Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA. Joseph.Cappello@genelux.com.
Joseph
J
Cappello
Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. marion.adelfinger@biozentrum.uni-wuerzburg.de.
Marion
M
Adelfinger
Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. aaszalay@genelux.com.
Aladar A
AA
Szalay
D000818:Animals; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D009369:Neoplasms / Q000628:therapy / Q000662:veterinary*; D050130:Oncolytic Virotherapy / Q000379:methods*; D016896:Treatment Outcome