Alternative eluent composition for LC-MS analysis of perfluoroalkyl acids in raw fish samples.
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used in industry for different purposes. Due to the harmful effects that these compounds might cause in living organisms, EFSA and EU CONTAM panel have issued a monitoring program for PFAAs in foodstuffs. This has given rise to intense research dedicated to the analysis of PFAAs over the past few years. This work focuses on chromatographic analysis of three PFAAs in fish. The analytes, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorooctanesulfonic acid (PFOS), are commonly associated with the production of fluoropolymers. Fluorinated alcohols are used as eluent components, and their possible advantages as eluent modifiers in LC-MS analysis of PFAAs, alternative retention mechanism and enhanced ionization efficiency, are examined. The analyzed fish samples originating from Estonian fresh and marine waters had low contents of PFAAs.
Institute of Chemistry , University of Tartu, 14a Ravila Street, 50411 Tartu, Estonia.
Tõiv
T
Haljasorg
Jaan
J
Saame
Karin
K
Kipper
Anu
A
Teearu
Koit
K
Herodes
Mari
M
Reinik
Ivo
I
Leito
D017738:Alkanesulfonic Acids / Q000032:analysis*; D000818:Animals; D002210:Caprylates / Q000032:analysis*; D002853:Chromatography, Liquid; D005227:Fatty Acids; D005399:Fishes; D005466:Fluorocarbons / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D013058:Mass Spectrometry; D017747:Seafood / Q000032:analysis*
D017738:Alkanesulfonic Acids; D002210:Caprylates; D005227:Fatty Acids; D005466:Fluorocarbons; C101816:perfluoro-n-nonanoic acid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid