Valproic acid-induced pancreatitis in a 15-year-old boy with juvenile myoclonic epilepsy.
Drug-induced acute pancreatitis is a rare condition in childhood, and information about the incidence of valproic acid-induced acute pancreatitis in the pediatric population is scarce. In this clinical case, we report a first documented pediatric case of valproic acid-induced pancreatitis in Estonia. A 15-year-old boy with juvenile myoclonic epilepsy developed acute pancreatitis after 2-month therapy with valproic acid. The symptoms of pancreatitis subsided within 1 week after the discontinuation of treatment with valproic acid. Acute pancreatitis should be suspected in any pediatric patient with gastrointestinal symptoms during valproate treatment.
Department of Pediatrics, University of Tartu, Lunini 6, 51014 Tartu, Estonia. kadi.veri@lastehaigla.ee.
Kadi
K
Veri
Oivi
O
Uibo
Inga
I
Talvik
Tiina
T
Talvik
D000208:Acute Disease; D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004957:Estonia; D006801:Humans; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy*; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D028761:Withholding Treatment
D000927:Anticonvulsants; D014635:Valproic Acid