Absolute configuration of amphidinin A.
The absolute configurations at six stereogenic centers in amphidinin A (1), a cytotoxic linear polyketide isolated from a symbiotic marine dinoflagellate, Amphidinium sp., were elucidated to be 2R, 4R, 6S, 9R 11R, and 12S by the combination of J-based configuration analysis, modified Mosher's method, and density-functional theory calculations.
Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
Takahiro
T
Iwai
Takaaki
T
Kubota
Jun'ichi
J
Kobayashi
D004141:Dinoflagellida / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
D005663:Furans; D061065:Polyketides; C000591100:amphidinin A