Vitamin A and dendritic cell differentiation.
Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differentiation of CD11b+ DC subsets in the mucosa as well as the spleen depend on vitamin A signalling. As CD11b+ DC subsets exert non-redundant functions in anti-bacterial and anti-fungal immune responses, defects in CD11b+ DC differentiation will contribute to the clinical problems observed during vitamin A deficiency.
Marieke R
MR
Beijer
Georg
G
Kraal
Joke M M
JM
den Haan
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D014801:Vitamin A / Q000494:pharmacology*; D014802:Vitamin A Deficiency / Q000276:immunology / Q000378:metabolism
D015415:Biomarkers; D039481:CD11b Antigen; C509295:ITGAM protein, human; D014801:Vitamin A