Iron ERRs with Salmonella.
The hormone hepcidin promotes iron sequestration by macrophages. A recent study by Kim et al. (2014) implicates the orphan receptor ERRγ (estrogen-related receptor γ) in the regulation of hepcidin production and suggests that targeting the ERRγ-hepcidin axis may be beneficial during infection with the facultative intracellular pathogen Salmonella.
Departments of Laboratory Medicine and Microbiology, University of Washington, Seattle, WA 98195-7735, USA. Electronic address: fcfang@uw.edu.
Ferric C
FC
Fang
Department of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology, and Pneumology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Günter
G
Weiss
D000818:Animals; D022781:Hepatocytes / Q000378:metabolism*; D064451:Hepcidins / Q000378:metabolism*; D015850:Interleukin-6 / Q000276:immunology*; D007501:Iron / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D012480:Salmonella Infections / Q000378:metabolism*; D012486:Salmonella typhimurium; D015398:Signal Transduction / Q000276:immunology*
D064451:Hepcidins; D015850:Interleukin-6; D011960:Receptors, Estrogen; D007501:Iron