Homicide and Klinefelter syndrome: a complex interaction.
BACKGROUND
Several studies have shown an association between homicide and sexual chromosomal abnormalities, but data are still lacking regarding Klinefelter syndrome.


METHODS
We retrospectively reviewed two cases of homicide perpetrators who were both diagnosed with Klinefelter syndrome on the basis of a karyotype analysis. A neurocognitive assessment was also performed (MMSE, Frontal Assessment Battery, brain CT, and electroencephalogram).


RESULTS
Numerous intermediate risk factors of homicide were shared by our two cases, including dispositional (male gender, young age, low socioeconomic status), historical (prior arrest record and past conviction for any offense), contextual (unemployment), and clinical (alcohol abuse).


CONCLUSIONS
It is important that clinicians go beyond obvious risk factors, such as chromosomal abnormalities, to pinpoint other meaningful risk factors and potentially facilitate preventive approaches.
McGill Group for Suicide Studies Montréal, Department of Psychiatry & Douglas Mental Health University Institute, McGill University, Québec, Canada.
Stéphane
S
Richard-Devantoy
McGill Group for Suicide Studies Montréal, Department of Psychiatry & Douglas Mental Health University Institute, McGill University, Québec, Canada.
Fabrice
F
Jollant
Institut Philippe-Pinel de Montréal, Montréal, Québec, Canada.
Anne-Isabelle
AI
Bouyer-Richard
Hospital of Psychiatry, Sainte-Gemmes-sur-Loire, Sainte-Gemmes-sur-Loire, France.
Jean-Paul
JP
Lhuillier
INSERM U894, Paris-Descartes University, CMME, Sainte-Anne Hospital, Paris, France.
Philip
P
Gorwood
D000328:Adult; D002869:Chromosome Aberrations; D057237:Criminals / Q000523:psychology*; D005260:Female; D006708:Homicide / Q000523:psychology*; D006801:Humans; D007361:Intelligence Tests; D007713:Klinefelter Syndrome / Q000523:psychology*; D008297:Male; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors