Antiphospholipid syndrome in Sarawak: real world experience in a developing country.
We performed a cross-sectional study of all antiphospholipid syndrome (APS) patients during an 8-year period (2006-2013) to describe the clinical features, serology profiles, treatment regimes, and outcomes in our center. There were a total of 59 patients in our study with the female to male ratio of 9:1. They have a mean age of 41.6 ± 12.1 years and a mean duration of illness of 38.4 ± 68.5 months. The majority of patients presented with vascular thrombosis (69.5 %) with equal arterial and venous involvements. Twenty-six patients (44.1 %) presented with obstetric complications with recurrent abortions (32.2 %) as the main manifestation. Most patients were on daily warfarin doses of 2-6 mg (91.0 %) with target INR of 2-3. There was neither recurrent thrombosis nor bleeding complications documented. There were 80 % live births following treatment in our patients.
Unit of Rheumatology, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia, tehchenglay@yahoo.com.
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D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D002308:Cardiolipins / Q000276:immunology*; D003430:Cross-Sectional Studies; D003906:Developing Countries; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies
D017152:Antibodies, Antiphospholipid; D002308:Cardiolipins