Association of GSTTI and GSTM1 variants with acute myeloid leukemia risk.
We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the duplex polymerase chain reaction with the confronting two-pair primer (PCR-CTPP) method. Individuals carrying null GSTTI and GSTM1 genotypes had a 1.52- and 1.78-fold increased risk of developing acute leukemia, respectively, compared to non-null genotype carriers (P < 0.05). A high risk was observed in those carrying a combination of null genotypes of GSTM1 and GSTTI with GSTP1-Val allele genotypes when compared with those carrying wild-type genotypes, with an odds ratio (95% confidence interval) of 3.62 (1.53-8.82) (P < 0.05). These findings indicate that genetic variants of GSTTI and GSTM1 significantly increase the risk of developing AML. Our study offers important insights into the molecular etiology of AML.
Department of Hematology, The First Affiliated Hospital, Xinxiang Medical University, China.
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Zi
Department of Hematology, The First Affiliated Hospital, Xinxiang Medical University, China wusun778@163.com.
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Wu
Hematology Research Laboratory, The First Affiliated Hospital, Xinxiang Medical University, China.
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Ma
Department of Hematology, The First Affiliated Hospital, Xinxiang Medical University, China.
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Yang
Department of Hematology, The First Affiliated Hospital, Xinxiang Medical University, China.
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Yang
Department of Hematology, The First Affiliated Hospital, Xinxiang Medical University, China.
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Huang
West China School of Public Health, Sichuan University, Chengdu, China.
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Yang
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1