Polymorphism of the cytochrome P-450 1A1 (A2455G) in women with breast cancer in Eastern Azerbaijan, Iran.
OBJECTIVE
Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. The present study evaluates the existence of CYP1A1 polymorphism in a number of breast cancer samples.


METHODS
One hundred breast cancer patients and the same number of healthy controls were analyzed for the A2455G polymorphism of cytochrome P-450 1A1 by the polymerase chain reaction-restriction fragment length polymorphism technique.


RESULTS
Frequency of heterozygote genotype (A/G) indicated significant increase in case group (17%) compared to control group (7%) (OR=2.7; 95% CI=1.07-6.89; P-value=0.03). The related result of (A/A) genotype showed significantly decreased risk of breast cancer (OR=0.34; P-value=0.01). Higher frequency of heterozygotes was mainly observed among premenopausal breast cancer patients.


CONCLUSIONS
Our results suggest that the CYP1A1 polymorphism may be useful for predicting breast cancer risk in our study population.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hakimeh
H
Saadatian
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Jalal
J
Gharesouran
Department of Thorax Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Vahid
V
Montazeri
Department of Plant Breeding & Biotechnology, Faculty of Agriculture University of Tabriz, Tabriz, Iran.
Seyyed Abolgasem
SA
Mohammadi
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Seyyed Mojtaba
SM
Mohaddes Ardabili
Breast cancer; CYP1A1; Polymorphism