Fatal methylene blue associated serotonin toxicity.
This is the first report of a fatal outcome from serotonin toxicity, precipitated by an interaction between methylene blue and venlafaxine. Methylene blue-associated serotonin toxicity has been described before but usually as mild toxicity. Its presentation after general anaesthesia may be atypical and therefore more difficult to diagnose. However, the syndrome is completely preventable if serotonin re-uptake inhibiting agents are stopped beforehand.
Department of Internal Medicine, Bethesda Hospital - Care Group Leveste Middenveld, Hoogeveen, the Netherlands.
W M C
WM
Top
P K
PK
Gillman
C J
CJ
de Langen
A
A
Kooy
D000368:Aged; D003511:Cyclohexanols / Q000009:adverse effects*; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000601:surgery; D008751:Methylene Blue / Q000009:adverse effects*; D020230:Serotonin Syndrome / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D000069470:Venlafaxine Hydrochloride
D003511:Cyclohexanols; D004791:Enzyme Inhibitors; D008751:Methylene Blue; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride