Maternofoetal complications and their association with proteinuria in a tertiary care hospital of a developing country.
OBJECTIVE. To investigate association between maternofoetal complications and the amount of proteinuria measured by spot urine protein creatinine ratio in patients with preeclampsia. METHODS. 200 consecutive patients with preeclampsia were recruited in the study. The complications like first episode of severe hypertension, renal insufficiency, raised level of aspartate transaminase, signs of neurological involvement, thrombocytopenia, eclampsia, and need to shift in intensive care units were studied. The maternal outcome was studied in terms of type of labour, outcome of pregnancy, mode of delivery, indication of cesarean section, and maternal mortality. The foetal complications and outcome parameters were birth weight, Apgar score at the time of birth and at five minutes, need of high dependency unit care, and perinatal mortality. RESULT. The frequency of various maternal and foetal complications was between 14-53% and 22-92%, respectively. Maternal mortality was 3%, whereas perinatal mortality was 23%. Statistically significant association was found between the frequencies of various complications in mother and newborn and spot UPCR. CONCLUSION. The rate of various maternofoetal complications in preeclampsia is higher in developing countries than in developed world. Maternofoetal complications and outcome correlate with maternal spot UPCR.
Department of Obstetrics and Gynaecology, Lady Hardinge Medical College and Associated Hospitals, New Delhi 110001, India.
Archana
A
Kumari
Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Avinash
A
Chakrawarty
Department of Obstetrics and Gynaecology, Lady Hardinge Medical College and Associated Hospitals, New Delhi 110001, India.
Abha
A
Singh
Department of Biochemistry, Lady Hardinge Medical college and Associated Hospitals, New Delhi 110001, India.
Ritu
R
Singh
D000328:Adult; D001034:Apgar Score; D001219:Aspartate Aminotransferases / Q000097:blood; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D003906:Developing Countries; D004461:Eclampsia / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007194:India / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008107:Liver Diseases / Q000097:blood / Q000453:epidemiology; D008428:Maternal Mortality; D054238:Perinatal Mortality; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000652:urine; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D011507:Proteinuria / Q000453:epidemiology*; D012021:Reflex, Abnormal; D051437:Renal Insufficiency / Q000453:epidemiology; D012720:Severity of Illness Index; D062606:Tertiary Care Centers; D013921:Thrombocytopenia / Q000453:epidemiology; D055815:Young Adult
D001219:Aspartate Aminotransferases