Endosomes as platforms for NOD-like receptor signaling.
The NOD-like receptors (NLRs) were among the first innate immune receptors discovered, yet a clear understanding of the basic principles underlying their mechanisms of action is lacking. Two recent studies provide important cell biological insights into the subcellular sites of NOD1- and NOD2-dependent signaling.
Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02446, USA.
Kevin S
KS
Bonham
Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02446, USA. Electronic address: jonathan.kagan@childrens.harvard.edu.
Jonathan C
JC
Kagan
D011992:Endosomes / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D053474:Nod1 Signaling Adaptor Protein / Q000235:genetics / Q000378:metabolism*; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein