New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata.
Two new apotirucallane-type triterpenoids, cedrodorols A-B (1 and 2), along with seven known compounds (3-9), were isolated from the twigs and leaves of Cedrela odorata. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with the IC50 values of 13.09 and 3.93 μg/ml, respectively.
a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
Wen-Bin
WB
Wu
Hua
H
Zhang
Shi-Hui
SH
Dong
Li
L
Sheng
Yan
Y
Wu
Jia
J
Li
Jian-Min
JM
Yue
D031587:Cedrela / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C514394:apotirucallane; C000591802:cedrodorol A; C000591803:cedrodorol B; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
Cedrela odorata; Meliaceae; PTP1B inhibitor; triterpenoid