Hydrogen gas presents a promising therapeutic strategy for sepsis.
Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF- κ B and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China ; Tianjin Institute of Anesthesiology, Tianjin 300052, China.
Keliang
0000-0003-0919-9768
K
Xie
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China ; Tianjin Institute of Anesthesiology, Tianjin 300052, China.
Lingling
L
Liu
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China ; Tianjin Institute of Anesthesiology, Tianjin 300052, China.
Yonghao
Y
Yu
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China ; Tianjin Institute of Anesthesiology, Tianjin 300052, China.
Guolin
G
Wang
D000818:Animals; D006801:Humans; D006859:Hydrogen / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy*; D012965:Sodium Chloride / Q000627:therapeutic use
D012965:Sodium Chloride; D006859:Hydrogen