The p value of HPIV3-mediated autophagy inhibition.
Autophagy, a vesicular pathway involving the lysosomal degradation of cytosolic contents, is frequently hijacked by intracellular pathogens to optimize their infectivity. In this issue of Cell Host & Microbe, Ding et al. (2014) show that human parainfluenza virus exploits autophagy by targeting SNAREs and preventing the SNAP29-Stx17 interaction, an otherwise crucial event in autophagosome-lysosome fusion.
CIRI, International Center for Infectiology Research, Université de Lyon, 69007 Lyon, France; Inserm, U1111, 69007 Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, 69007 Lyon, France; Ecole Normale Supérieure de Lyon, 69007 Lyon, France; CNRS, UMR5308, 69007 Lyon, France. Electronic address: mathias.faure@inserm.fr.
Mathias
M
Faure
D006801:Humans; D008247:Lysosomes / Q000502:physiology*; D010224:Parainfluenza Virus 3, Human / Q000502:physiology*; D010588:Phagosomes / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism*; D010253:Respirovirus Infections / Q000503:physiopathology*; D014764:Viral Proteins / Q000378:metabolism*
D010750:Phosphoproteins; D014764:Viral Proteins