Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.
Until recently, no direct comparison between [(15)O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL) magnetic resonance imaging (MRI) and [(15)O]water PET. Quantitative CBF values were compared in 10 young healthy male volunteers at baseline conditions. A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively. The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBF between ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [(15)O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.
Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.
Ke
K
Zhang
Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.
Hans
H
Herzog
Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.
Jörg
J
Mauler
Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.
Christian
C
Filss
FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Thomas W
TW
Okell
Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.
Elena Rota
ER
Kops
Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.
Lutz
L
Tellmann
Department of Psychology, Dresden University of Technology, Dresden, Germany.
Thomas
T
Fischer
Department of Psychology, Dresden University of Technology, Dresden, Germany.
Burkhard
B
Brocke
Department of Neurology, University of Aachen, Aachen, Germany.
Walter
W
Sturm
1] Institute of Neuroscience and Medicine-5: Nuclear Chemistry, Forschungszentrum Jülich, Jülich, Germany [2] JARA Brain-Translational Brain Medicine, Germany.
Heinz H
HH
Coenen
1] Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany [2] Department of Neurology, University of Aachen, Aachen, Germany [3] JARA Brain-Translational Brain Medicine, Germany.
N Jon
NJ
Shah
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D013113:Spin Labels; D014867:Water / Q000737:chemistry; D055815:Young Adult
D010104:Oxygen Radioisotopes; D013113:Spin Labels; D014867:Water