Glycogen synthase kinase-β3 in ischemic neuronal death.
Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
Pradeep
P
Hanumanthappa
Asha
A
Densi
Associate Professor & Head, School of Biotechnology, Coordinator, DBT - Centre for Bioinformatics, National Institute of Technology Calicut, Calicut - 673601, India. rajanikant@nitc.ac.in.
Rajanikant Golgodu
RG
Krishnamurthy
D000818:Animals; D002545:Brain Ischemia / Q000201:enzymology* / Q000473:pathology*; D016923:Cell Death; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D009474:Neurons / Q000473:pathology*
C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3