Multifunctional theranostic red blood cells for magnetic-field-enhanced in vivo combination therapy of cancer.
Red blood cells are attached to iron oxide nanoparticles pre-coated with chlorine e6, a photosensitizer, and then loaded with a chemotherapeutic drug, doxorubicin, to enable imaging-guided combined photodynamic and chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise of integrating cell-based drug-delivery systems with nanotechnology as a biocompatible multifunctional platform for applications in cancer theranostics.
Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Chao
C
Wang
Xiaoqi
X
Sun
Liang
L
Cheng
Shengnan
S
Yin
Guangbao
G
Yang
Yonggang
Y
Li
Zhuang
Z
Liu
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy*; D045744:Cell Line, Tumor; D058948:Cell Tracking / Q000379:methods; D002735:Chlorophyllides; D003131:Combined Modality Therapy / Q000379:methods; D004317:Doxorubicin / Q000008:administration & dosage*; D017707:Erythrocyte Transfusion / Q000379:methods*; D004912:Erythrocytes / Q000737:chemistry / Q000166:cytology; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D010789:Phototherapy / Q000379:methods; D011166:Porphyrins / Q000008:administration & dosage* / Q000737:chemistry
D002735:Chlorophyllides; D058185:Magnetite Nanoparticles; D011166:Porphyrins; C062985:phytochlorin; D004317:Doxorubicin
biomaterials; combination therapy; drug delivery; magnetic targeting; red blood cells