Investigation of anti-Toxocara and anti-toxoplasma antibodies in patients with schizophrenia disorder.
Objective. The aim of the present study was to examine the relationship between Toxoplasma gondii and Toxocara spp. infections in patients with schizophrenia disorder. Method. A total of 100 patients with schizophrenia disorder and 95 healthy individuals participated in the study. Participants were tested for the presence of anti-T. gondii and anti-Toxocara spp. antibodies by ELISA and Western blotting. Data were analyzed using Chi-square test and Fisher 9 s exact test. Results. There were no differences in T. gondii IgG seroprevalence between patients with schizophrenia and healthy individuals (P = 0.1), but there were differences in seroprevalence between males and females with schizophrenia (P = 0.009). In contrast, Toxocara spp. IgG seroprevalence was greater in patients with schizophrenia disorder than in healthy individuals (P = 0.02), but there were no differences in seroprevalence between men and women with schizophrenia (P = 0.5). Finally, there were no differences in seroprevalence of T. gondii or Toxocara spp. IgG among different subtypes of schizophrenia, various age groups, residential area, or clinical course of treatment (P > 0.05). Conclusion. The present study suggests that patients with schizophrenia disorder are at elevated risk of Toxocara spp. infection. Moreover, contamination with T. gondii is a risk factor for schizophrenia in women.
Health Research Institute, Infectious and Tropical Diseases Research Center, Department of Medical Parasitology, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 613715794, Ahvaz, Iran.
Shahram
S
Khademvatan
Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Niloufar
N
Khajeddin
Department of Psychology, Shahid Chamran University, Ahvaz, Iran.
Sakineh
S
Izadi
Research Institute for Infectious Disease of Digestive System, Department of Medical Parasitology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Elham
E
Yousefi