Bio-sensitive activities of coordination compounds containing 1,10-phenanthroline as co-ligand: synthesis, structural elucidation and dna binding properties of metal(II) complexes.
Present work reports the DNA binding and cleavage characteristics of a series of mixed-ligand complexes having the composition [M(L)(phen)2]Cl2 (where M=Cu(II), Ni(II), Co(II) and Zn(II) and phen as co-ligand) in detail. Their structural features and other properties have been deduced from their elemental analyses, magnetic susceptibility and molar conductivity as well as from IR, UV-Vis, (1)H NMR and EPR spectral studies. The UV-Vis, magnetic susceptibility and EPR spectral data of metal complexes suggest an octahedral geometry. The binding properties of these complexes with calf thymus DNA (CT-DNA) have been explored using electronic absorption spectroscopy, viscosity measurement, cyclic voltammetry and differential pulse voltammetry. The DNA-binding constants for Cu(II), Ni(II), Co(II), and Zn(II) complexes are 6.14×10(5)M(-1), 1.8×10(5)M(-1), 6.7×10(4)M(-1) and 2.5×10(4)M(-1) respectively. Detailed analysis reveals that these complexes interact with DNA through intercalation binding. Nuclease activity has also been investigated by gel electrophoresis. Moreover, the synthesized Schiff base and its mixed-ligand complexes have been screened for antibacterial and antifungal activities. The data reveal that the complexes exhibit higher activity than the parent ligand.
Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India. Electronic address: ramchem1964@gmail.com.
Natarajan
N
Raman
Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
Rajkumar
R
Mahalakshmi
Department of Chemistry, University of Pitesti, Pitesti 110040, Romania.
Liviu
L
Mitu
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D001665:Binding Sites; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008024:Ligands; D009181:Mycoses / Q000188:drug therapy; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis
D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D010618:Phenanthrolines; D004247:DNA; C427203:calf thymus DNA; C025205:1,10-phenanthroline
1,10-Phenanthroline; Antibacterial activity; DNA binding; DNA cleavage; Metal complexes