Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study.
OBJECTIVE
We examined secular trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects.


METHODS
A total of 2,490 subjects in 1988 and 2,852 subjects in 2002 aged 40-79 years underwent a 75-g oral glucose tolerance test, and their glucose tolerance status was defined by the 1998 World Health Organization criteria.


RESULTS
The age-adjusted prevalence of type 2 diabetes increased significantly from 1988 to 2002 in men (14.6% in 1988 to 20.8% in 2002, P < 0.001) and women (9.1% in 1988 to 11.2% in 2002, P = 0.002). A significant rise in the age-adjusted prevalence of prediabetes was also observed in both sexes (26.2% in 1988 to 35.3% in 2002, P < 0.001 for men; 22.5% in 1988 to 25.1% in 2002, P = 0.04 for women). In age-stratified analysis, the prevalence of type 2 diabetes increased markedly over time in men aged 60-69 and 70-79 years (both P < 0.001) and women aged 70-79 years (P = 0.02). The prevalence of overall and central obesity increased significantly in men aged 60-69 and 70-79 years, and women aged 70-79 years from 1988 to 2002, whereas the frequency of regular exercise decreased significantly in men aged 70-79 years between the surveys.


CONCLUSIONS
Our findings suggest that the prevalence of type 2 diabetes and prediabetes increased significantly in both sexes from the 1980s to the 2000s in a general Japanese population, and that the increasing prevalence of obesity and the decline in physical activity exerted an influence on this rising trend.
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Naoko
N
Mukai
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Yasufumi
Y
Doi
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Toshiharu
T
Ninomiya
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Yoichiro
Y
Hirakawa
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Masaharu
M
Nagata
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Daigo
D
Yoshida
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Jun
J
Hata
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan ; Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Masayo
M
Fukuhara
Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Udai
U
Nakamura
Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Takanari
T
Kitazono
Department of Environmental Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Yutaka
Y
Kiyohara
Prediabetes; Prevalence; Type 2 diabetes