Autonomic neuropathy resulting in recurrent laryngeal nerve palsy in an HIV patient with Hodgkin lymphoma receiving vinblastine and antiretroviral therapy.
Hoarseness of voice due to vocal cord paresis as a result of recurrent laryngeal nerve palsy has been well recognised. Recurrent laryngeal nerve palsy is commonly caused by compression due to tumour or lymph nodes or by surgical damage. Vinca alkaloids are well known to cause peripheral neuropathy. However, vinca alkaloids causing recurrent laryngeal nerve palsy has been reported rarely in children. We report a case of an adult patient with HIV who developed hoarseness of voice due to vocal cord paralysis during vinblastine treatment for Hodgkin lymphoma. Mediastinal and hilar lymph node enlargement in such patients may distract clinicians from considering alternative causes of recurrent laryngeal nerve palsy, with potential ensuing severe or even life-threatening stridor.
Department of Genitourinary and HIV Medicine, Singleton Hospital, Swansea, UK Soumeya.cherif@wales.nhs.uk.
S
S
Cherif
Department of Genitourinary and HIV Medicine, Singleton Hospital, Swansea, UK.
S
S
Danino
Department of Genitourinary and HIV Medicine, Singleton Hospital, Swansea, UK.
K
K
Yoganathan
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D001706:Biopsy; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006685:Hoarseness / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011859:Radiography; D061226:Recurrent Laryngeal Nerve Injuries; D016896:Treatment Outcome; D014747:Vinblastine / Q000009:adverse effects / Q000627:therapeutic use*; D014826:Vocal Cord Paralysis / Q000139:chemically induced* / Q000150:complications; D014827:Vocal Cords / Q000000981:diagnostic imaging / Q000294:innervation
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine
AIDS; HIV; Hodgkin lymphoma; antiretroviral therapy; neuropathy; recurrent laryngeal nerve palsy; vinblastine; vinca alkaloids; vocal cords