Effect of a new combined therapy with nano-carbonate apatite and CO2 laser on dentin hypersensitivity in an in situ model.
OBJECTIVE
The aim of this study was to determine the occluding effects of a combination of dentifrice containing nano-carbonate apatite (n-CAP) and CO2 laser on dentinal tubules, and to evaluate the acid resistance of this combination after 4 days of treatment, by using an in situ model.


BACKGROUND
The synergic effect of this combination was demonstrated in an in vitro study.


METHODS
This was a two period crossover, single-blind, randomized, four-treatment, split-mouth study. Ten healthy participants wore lower intraoral appliances during the treatment period. Specimens were divided into the following four groups: no treatment (control group), tooth-brushing using 20% n-CAP dentifrice (n-CAP group), CO2 laser irradiation (laser group), and laser irradiation after n-CAP application (combined group). Occluding effects were evaluated on 2 days (days 1 and 2), and then acid challenge was performed using grape juice on 2 days (days 3 and 4). All of the specimen surfaces were evaluated by a scanning electron microscope.


RESULTS
The combined group showed a better occluding effect than control group compared with other treatment groups, and this effect was 20% higher than that in the n-CAP group. Also, the combined group had the smallest open dentinal tubular area among all of the treatment groups.


CONCLUSIONS
The combined therapy is a promising method for ensuring a long-lasting effect of dentin hypersensitivity treatment in clinical practice.
1 Department of Preventive Dentistry and Public Oral Health, College of Dentistry, Yonsei University , Seoul, Korea.
Sun Young
SY
Han
Ji Sun
JS
Kim
Young Seok
YS
Kim
Ho Keun
HK
Kwon
Baek Il
BI
Kim
D001031:Apatites / Q000008:administration & dosage*; D018592:Cross-Over Studies; D003802:Dentifrices / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006801:Humans; D054020:Lasers, Gas; D011897:Random Allocation; D016037:Single-Blind Method
D001031:Apatites; D003802:Dentifrices; C030782:carboapatite