Oxycodone vs. fentanyl patient-controlled analgesia after laparoscopic cholecystectomy.
OBJECTIVE
Oxycodone is semi-synthetic opioid, oral and parenteral preparations have been widely used for acute and chronic pain. The aim of this study was to assess the efficacy and side effects of oxycodone and fentanyl in patient controlled analgesia (PCA) after laparoscopic cholecystectomy.


METHODS
A prospective, randomized, double-blind study was conducted. 81 patients were randomly divided into two groups; fentanyl (10 mcg fentanyl and 1.5 mg ketorolac) and oxycodone group (1 mg oxycodone and 1.5 mg ketorolac). After the operation, a blinded observer assessed pain using a numerical rating scale (NRS), infused PCA dose, side effects, sedation levels, and satisfaction.


RESULTS
Cumulative PCA dose of oxycodone group at 48 h (31.4 ± 16.0 ml) was significantly less than that of fentanyl group (43.8 ± 23.1 ml, P = 0.009). Oxycodone group showed more nausea at 6-24 h after the operation (P = 0.001), but there was no difference in satisfaction score (P = 0.073). There were no significant differences in other side effects, sedation and NRS scores between two groups.


CONCLUSIONS
Oxycodone showed comparable effects for pain relief compared to fentanyl in spite of less cumulative PCA dose. Based on these results, we could conclude that oxycodone may be useful as an alternative to fentanyl for PCA after laparoscopic cholecystectomy.
Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Boo-Young
BY
Hwang
Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Jae-Young
JY
Kwon
Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Eunsoo
E
Kim
Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Do-Won
DW
Lee
Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Tae-Kyun
TK
Kim
Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Hae-Kyu
HK
Kim
D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled; D002763:Cholecystectomy; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D020910:Ketorolac / Q000008:administration & dosage; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010098:Oxycodone / Q000008:administration & dosage*; D059408:Pain Management; D010149:Postoperative Pain / Q000188:drug therapy* / Q000473:pathology
D010098:Oxycodone; D005283:Fentanyl; D020910:Ketorolac
Fentanyl; Laparoscopic cholecystectomy surgery; Oxycodone; Patient-controlled analgesia; Postoperative pain.