Manganese porphyrin-double stranded DNA complex guided in situ deposition of polyaniline for electrochemical thrombin detection.
In this work, we proposed a novel electrochemical strategy for sensitive detection of thrombin (TB) based on in situ generation of polyaniline (PANI) as a redox mediator by using a manganese porphyrin-double stranded DNA (MnTMPyP-dsDNA) peroxidase-like artificial enzyme mimic as a powerful catalyst and template.
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. yqchai@swu.edu.cn yuanruo@swu.edu.cn.
Shunbi
S
Xie
Yaqin
Y
Chai
Yali
Y
Yuan
Ruo
R
Yuan
D000814:Aniline Compounds / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000737:chemistry; D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D008345:Manganese / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013917:Thrombin / Q000032:analysis* / Q000737:chemistry
D000814:Aniline Compounds; D052157:Aptamers, Nucleotide; D011166:Porphyrins; C416807:polyaniline; C081676:thrombin aptamer; D008345:Manganese; D004247:DNA; D013917:Thrombin