Hepatitis B virus-associated nephropathy in a patient with diabetes mellitus.
Hepatitis B virus (HBV)-associated nephropathy is not a rare manifestation of HBV infection; this could result in diagnostic confusion and the possible misidentification of a diabetic patient with albuminuria. We present the first published case of a HBV-associated nephropathy occurring in a patient with diabetes. The patient was a 24-year-old man who was admitted to hospital with 4 days of generalized swelling and oliguria. He had a 3-year history of weight loss, and a 1-year history of polydipsia and polyuria before the symptoms of generalized swelling and oliguria appeared. Laboratory tests showed a fasting blood sugar of 15.1 mmol/L and glycated hemoglobin of 18.1%. The 24-h urine protein excretion was 2807.8 mg and serum albumin was 19.1 g/L. The diagnosis of HBV-associated nephropathy was confirmed by serological evaluations of HBV antigen and antibodies, immunohistochemical evidence of HBV-related antigens, and immune complexes in renal biopsies. The decreased proteinuria was observed after antiviral therapy.
Department of Renal Medicine The Second Affiliated Hospital ZheJiang University College of Medicine Hangzhou Zhejiang China.
Qing-Ling
QL
Zou
Department of Renal Medicine The Second Affiliated Hospital ZheJiang University College of Medicine Hangzhou Zhejiang China.
Gui-Na
GN
Wei
Department of Renal Medicine The Second Affiliated Hospital ZheJiang University College of Medicine Hangzhou Zhejiang China.
Jia-Xi
JX
Chen
Department of Pathology The Second Affiliated Hospital ZheJiang University College of Medicine Hangzhou Zhejiang China.
Qin
Q
Ye
Department of Endocrinology and Metabolism The Second Affiliated Hospital ZheJiang University College of Medicine Hangzhou Zhejiang China.
Peng-Fei
PF
Shan
Diabetes mellitus; Diabetic nephropathy; Hepatitis B virus‐associated nephropathy