The relationships between clinical characteristics, alcohol and psychotropic exposure, and circadian gene expression in human postmortem samples of affective disorder and control subjects.
Circadian abnormalities may be related to mood disorders. Circadian gene expression was measured in postmortem brain tissue from individuals with affective disorders and controls. Relationships between circadian gene expression, clinical characteristics, and alcohol and psychotropic medication use were noted. Further study is warranted to characterize these relationships.
Department of Psychiatry, Paul L. Foster School of Medicine, Texas Tech University Health Science Center in El Paso, El Paso, TX, USA. Electronic address: Robert99.Gonzalez@ttuhsc.edu.
Robert
R
Gonzalez
Section of Psychiatry, Makati Medical Center, Department of Neurosciences, Makati City, Philippines.
Carmina
C
Bernardo
Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Dianne
D
Cruz
Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Consuelo
C
Walss-Bass
Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Peter M
PM
Thompson
D000428:Alcohol Drinking / Q000235:genetics*; D001344:Autopsy; D001714:Bipolar Disorder / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D057906:Circadian Clocks / Q000235:genetics; D002940:Circadian Rhythm / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000235:genetics* / Q000473:pathology*; D056950:Period Circadian Proteins / Q000235:genetics*; D011180:Postmortem Changes; D012016:Reference Values
D056950:Period Circadian Proteins
Bipolar disorder; Circadian genes; Major depressive disorder