Fabrication of robust hydrogel coatings on polydimethylsiloxane substrates using micropillar anchor structures with chemical surface modification.
A durable hydrophilic and protein-resistant surface of polydimethylsiloxane (PDMS) based devices is desirable in many biomedical applications such as implantable and microfluidic devices. This paper describes a stable antifouling hydrogel coating on PDMS surfaces. The coating method combines chemical modification and surface microstructure fabrication of PDMS substrates. Three-(trimethoxysilyl)propyl methacrylates containing C═C groups were used to modify PDMS surfaces with micropillar array structures fabricated by a replica molding method. The micropillar structures increase the surface area of PDMS surfaces, which facilitates secure bonding with a hydrogel coating compared to flat PMDS surfaces. The adhesion properties of the hydrogel coating on PDMS substrates were characterized using bending, stretching and water immersion tests. Long-term hydrophilic stability (maintaining a contact angle of 55° for a month) and a low protein adsorption property (35 ng/cm(2) of adsorbed BSA-FITC) of the hydrogel coated PDMS were demonstrated. This coating method is suitable for PDMS modification with most crosslinkable polymers containing C═C groups, which can be useful for improving the anti-biofouling performance of PDMS-based biomedical microdevices.
Department of Mechanical Engineering and ‡Department of Pharmaceutical Sciences University of British Columbia , Vancouver, British Columbia V6T 1Z4, Canada.
Hongbin
H
Zhang
Chao
C
Bian
John K
JK
Jackson
Farzad
F
Khademolhosseini
Helen M
HM
Burt
Mu
M
Chiao
D000327:Adsorption; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D004129:Dimethylpolysiloxanes; D011108:Polymers; D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C013830:baysilon