Silver-mediated radical cyclization: construction of Δ(2)-isoxazolines from α-halo ketoximes and 1,3-dicarbonyl compounds.
A novel route to Δ(2)-isoxazolines is presented via silver-mediated radical cyclization of α-halo ketoximes with 1,3-dicarbonyl compounds. This method is performed using a radical strategy, and represents a new example of silver-initiated generation of oxime radicals for the formation of the C(sp(3))-O bonds.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. jhli@hnu.edu.cn.
Yan-Yun
YY
Liu
Xu-Heng
XH
Yang
Ji
J
Yang
Ren-Jie
RJ
Song
Jin-Heng
JH
Li
D001555:Benzene Derivatives / Q000737:chemistry*; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
D001555:Benzene Derivatives; D005609:Free Radicals; D006846:Hydrocarbons, Halogenated; D007555:Isoxazoles; D010091:Oximes; D012834:Silver