Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss.
OBJECTIVE
This study aims to investigate the correlation between serum anti-heat-shock protein 70 (anti-HSP 70) levels, serum paraoxonase (PON) levels and prognosis of idiopathic sudden sensorineural hearing loss (ISSHL).


METHODS
Twenty-five patients with ISSHL as the study group and 25 healthy volunteers as the control group were enrolled in this study. Blood samples were obtained from all patients before the treatment initiation and on the 10th day of the treatment from only patients of the study group. Idiopathic sudden sensorineural hearing loss was defined as the hearing loss between 250-6.000 Hz frequencies. The recoveries in the hearing thresholds were evaluated at 10 days of the treatment.


RESULTS
When the pre-treatment serum PON, anti-HSP 70 levels and the post-treatment serum PON, anti-HSP 70 levels of the patients with ISSHL were compared, we observed that the post-treatment serum PON levels of the recovered patients increased, while the post-treatment serum anti-HSP 70 levels of recovered patients decreased.


CONCLUSIONS
We believe that serum levels of anti-HSP 70 and PON can be used as markers for estimating and evaluating the prognosis of ISSHL patients.
Department of Otolaryngology, Elazığ Training and Research Hospital, 23200 Elazığ, Turkey.
Sertaç
S
Düzer
Hayrettin Cengiz
HC
Alpay
Dilara
D
Kaman
Oner
O
Sakallıoğlu
Sinasi
S
Yalçın
Irfan
I
Kaygusuz
Turgut
T
Karlıdağ
Erol
E
Keleş
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D001301:Audiometry, Pure-Tone; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006319:Hearing Loss, Sensorineural / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D003639:Hearing Loss, Sudden / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D043303:Aryldialkylphosphatase