Biological properties and molecular targets of umbelliprenin--a mini-review.
7-Prenyloxycoumarins are a group of secondary metabolites found mainly in plants belonging to the families Rutaceae and Apiaceae. Auraptene, umbelliprenin (UM), and 7-isopentenyloxycoumarin are some examples of prenylated coumarins. UM occurs in various edible plant species including celery, coriander, angelica, lemon, and particularly, Ferula species. Although UM was isolated more than 50 years ago, its biological activities have been studied since the last two decades. Besides anticancer activities, biological activities including anti-inflammatory, antioxidant, and antileishmanial activities have been reported from this natural compound. The present mini-review deals with the biological activities and mechanism of actions reported for UM.
a Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences , Mashhad , Iran.
Abolfazl
A
Shakeri
Milad
M
Iranshahy
Mehrdad
M
Iranshahi
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018320:Leishmania major / Q000187:drug effects; D015394:Molecular Structure; D027821:Rutaceae / Q000737:chemistry*; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C461443:7-isopentenyloxycoumarin; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D003374:Coumarins; D014468:Umbelliferones; C105832:aurapten; C003744:umbelliprenin
Apiaceae; Ferula; coumarin; umbelliprenin