Multivalent comb-type aptamer-siRNA conjugates for efficient and selective intracellular delivery.
In this study, a simple and efficient strategy for selective intracellular delivery of RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense strands and aptamer-incorporating sense strands.
Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea. hjmok@konkuk.ac.kr.
Hyundong
H
Yoo
Hyosook
H
Jung
Seung An
SA
Kim
Hyejung
H
Mok
D052157:Aptamers, Nucleotide / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003062:Codon; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D016372:RNA, Antisense / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use
D052157:Aptamers, Nucleotide; D003062:Codon; D016372:RNA, Antisense; D034741:RNA, Small Interfering