Reprint of: Environments of B cell development.
B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology.
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Motokazu
M
Tsuneto
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Ekaterina
E
Kajikhina
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Katharina
K
Seiler
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Andreas
A
Reimer
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Julia
J
Tornack
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Corinne
C
Bouquet
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Szandor
S
Simmons
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Marko
M
Knoll
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
Ingrid
I
Wolf
German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Koji
K
Tokoyoda
German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Anja
A
Hauser
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Takahiro
T
Hara
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Shizue
S
Tani-ichi
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Koichi
K
Ikuta
German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Joachim R
JR
Grün
German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Andreas
A
Grützkau
Cellular and Molecular Immunology, University of Göttingen, Germany.
Niklas
N
Engels
Cellular and Molecular Immunology, University of Göttingen, Germany.
Jürgen
J
Wienands
Department of Immunology, National Institutes of Infectious Diseases, Tokyo, Japan.
Yuki
Y
Yanagisawa
Department of Immunology, National Institutes of Infectious Diseases, Tokyo, Japan.
Kazuo
K
Ohnishi
Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany. Electronic address: melchers@mpiib-berlin.mpg.de.
Fritz
F
Melchers
B cell development; Endothelial cells; Fetal liver; Mesenchymal cells