Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population.
OBJECTIVE
Utility values that can be used in the economic evaluation of treatments for epilepsy can be elicited from the general population and the patient population, but it is unclear how the health state values differ. The aim of this study is to compare the preferences of the general population and a sample of people with epilepsy for health states described by the NEWQOL-6D QALY measure.


METHODS
The Time Trade Off preference elicitation technique was used to value eight NEWQOL-6D health states. The general population sample was recruited and interviewed in their homes, and the sample with epilepsy was recruited and interviewed in an epilepsy service in North West England. Descriptive analysis and regression modeling were used to compare health state values across the populations.


RESULTS
A sample of 70 people with epilepsy and a sample of 60 members of the general population were included. The populations differed across a range of background characteristics, but there were limited differences between the health state values. Patients provided significantly higher (better) values for the most severe health state described by the NEWQOL-6D (p<0.01) and nonsignificant higher values for states with intermediate severity. The general population health state value was only higher for the best health state described by the NEWQOL-6D.


CONCLUSIONS
The similarities in the patient and general population values for NEWQOL-6D health states suggest that the use of the general population utility weights for the estimation of QALYs in the economic evaluation of epilepsy interventions is appropriate and largely representative of patient preferences.
Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, Sheffield S1 4DA, UK. Electronic address: b.mulhern@sheffield.ac.uk.
Brendan
B
Mulhern
Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, Sheffield S1 4DA, UK.
Donna
D
Rowen
Institute of Psychology, Health and Society, University of Liverpool, UK.
Dee
D
Snape
Institute of Psychology, Health and Society, University of Liverpool, UK.
Ann
A
Jacoby
Division of Neurological Sciences, University of Liverpool, UK.
Tony
T
Marson
Centre for Health Economics and Medicines Evaluation, Bangor University, UK.
Dyfrig
D
Hughes
Division of Neurological Sciences, University of Liverpool, UK.
Gus
G
Baker
Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, Sheffield S1 4DA, UK.
John
J
Brazier
D000328:Adult; D000367:Age Factors; D004827:Epilepsy / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012016:Reference Values; D012044:Regression Analysis; D012737:Sex Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
Health state valuation; Health-related quality of life; Patient; Quality adjusted life year; Time Trade Off