Successful treatment of an essential thrombocythemia patient complicated by Sweet's syndrome with combination of chemotherapy and lenalidomide.
A 79-year-old man had been followed up since July 2003 based on a diagnosis of essential thrombocythemia (ET). The patient visited our hospital after developing a high fever and rash in August 2010, and Sweet's syndrome was diagnosed based on skin biopsy results. The bone marrow aspirate showed features like those of myelodysplastic/myeloproliferative neoplasm (MDS/MPN, unclassifiable). Administration of metenolone and azacitidine was initiated in March and May 2011, respectively, but the rash associated with Sweet's syndrome showed exacerbation. Ranimustine was therefore administered starting in July 2011 to control the blood cell count, but the rash associated with Sweet's syndrome persisted. Combination therapy with lenalidomide was initiated in September 2012, and resulted in control of the blood cell count and marked improvement of Sweet's syndrome.
Department of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital.
Michiko
M
Yamada
Hiroyuki
H
Kuroda
Masahiro
M
Yoshida
Wataru
W
Jomen
Tomoyuki
T
Abe
Tamaki
T
Sakurai
Shigeyuki
S
Fujii
Masahiro
M
Maeda
Miri
M
Fujita
Kazuo
K
Nagashima
Teppei
T
Matsuno
Masanori
M
Sato
Junji
J
Kato
D000368:Aged; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000473:pathology; D054437:Myelodysplastic-Myeloproliferative Diseases / Q000209:etiology / Q000473:pathology; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013920:Thrombocythemia, Essential / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
D009607:Nitrosourea Compounds; D013792:Thalidomide; D000077269:Lenalidomide; C020766:ranimustine