Cerebrospinal fluid cystatin C levels following treatment for aneurysmal subarachnoid hemorrhage.
OBJECTIVE
To investigate the changes of cerebrospinal fluid (CSF) cystatin C (CC) levels associated with the postoperative ischemic conditions and prognostic outcome in patients with aneurysmal subarachnoid hemorrhage (SAH).


METHODS
The study group consisted of 40 patients with microsurgically clipped intracranial aneurysms (IA's) and 22 control CSF samples. In patients, CSF samples were taken from the lumbar intrathecal catheter for CC measurement, at the beginning of operation, immediately after the operation (early postoperative), and the first postoperative day (late postoperative).


RESULTS
CC levels in three periods were significantly higher in patients with Hunt-Hess scores of 4, 5 than 1, 2, 3. There was a significant difference between the CC concentrations on the first postoperative day and controls. In patients who developed focal cerebral ischemia, CC levels at early and late postoperative periods were significantly higher than the group without ischemia. In addition, patients with poor prognostic outcome (GOS score of 1, 2, 3) had significantly higher levels of CC in all three periods than that of patients with good outcome (GOS score of 4, 5).


CONCLUSIONS
The raised CSF CC concentrations appear to be associated with the severity of bleeding, intraoperative ischemic events and poor prognostic outcome in patients with aneurysmal SAH.
Akdeniz University, School of Medicine, Department of Neurosurgery, Antalya, Turkey.
Ethem
E
Goksu
Ebru
E
Goksu
Bilge
B
Karsli
Mahmut
M
Akyuz
Halide
H
Akbas
Ali
A
Unal
Neval
N
Boztug
Recai
R
Tuncer
D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000209:etiology; D055316:Cystatin C / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000134:cerebrospinal fluid / Q000209:etiology; D011184:Postoperative Period; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000601:surgery
C525030:CST3 protein, human; D055316:Cystatin C