Sleep deprivation reduces tear secretion and impairs the tear film.
OBJECTIVE
We investigated whether sleep deprivation (SD) disturbs the tear film.


METHODS
A total of 20 healthy male subjects with no ocular disease was recruited: 10 were allocated to the SD group and 10 to the control group The 10 subjects in the SD group were deprived of sleep in an experimental setting and their outcomes were compared to those of the control group, which was not sleep-deprived. Tear film and ocular surface were evaluated at 2 PM, 10 PM, and 6 AM and 2 PM the following day. Tear osmolarity, Schirmer's test, tear film break-up time (TBUT), pain on a visual analog scale (VAS), and IOP were measured.


RESULTS
At 6 AM the following day, mean tear osmolarity level increased (P = 0.004), TBUT was significantly shorter (P = 0.01), and tear secretion measured by Schirmer's test was significantly reduced in the SD group than in the control group (P = 0.004). No significant change in IOP was observed in either group.


CONCLUSIONS
Sleep deprivation induced tear hyperosmolarity, shortened TBUT, and reduced tear secretion, all of which can trigger the development of ocular surface diseases. Therefore, SD can exacerbate signs and symptoms in patients with ocular surface diseases. (ClinicalTrials.gov number, NCT02026986.).
Department of Ophthalmology, Hallym University College of Medicine, Seoul, Korea.
Young Bok
YB
Lee
Department of Ophthalmology, Chosun University School of Medicine, Kwangju, Republic of Korea.
Jae Woong
JW
Koh
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
Joon Young
JY
Hyon
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Won Ryang
WR
Wee
Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
Jin Joo
JJ
Kim
Department of Ophthalmology, Hallym University College of Medicine, Seoul, Korea.
Young Joo
YJ
Shin
D000328:Adult; D001767:Blinking / Q000502:physiology; D003315:Cornea / Q000294:innervation / Q000378:metabolism*; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure; D007765:Lacrimal Apparatus / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D010147:Pain Measurement; D012892:Sleep Deprivation / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D013499:Surface Properties; D013666:Tears / Q000378:metabolism*; D055815:Young Adult
sleep deprivation; tear break-up time; tear hyperosmolarity; tear secretion