The impact on graft survival of interstitial inflammation in borderline change of allograft kidneys.
OBJECTIVE
In kidney transplantation cases, borderline change (BL) can lead to a progressive course. However, factors related to outcome and the progress of BL are not well defined. In this study, we focused specifically on interstitial inflammation as a factor influencing outcome after diagnosis of BL.


METHODS
We followed 252 recipients who underwent renal transplantation between 1998 to 2012 at our hospital. Of those, we retrospectively studied 40 diagnosed with BL from allograft biopsy findings, and then classified them as BL1 and BL2 according to the level of interstitial inflammation (i) (BL1: i < 10%, BL2: i ≥ 10%).


RESULTS
There were 21 BL1 and 19 BL2 cases, of whom 7 developed rejection during the follow-up period. There were no significant differences for graft survival rate and the rate leading to acute rejection between the 2 groups (P = 0.44, P = 0.69). Univariate analysis showed that the grade of interstitial inflammation was not a significant risk factor for developing acute rejection (P = 0.816).


CONCLUSIONS
Our results show that the level of interstitial inflammation does not have an effect on a progressive BL course.
Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
Kazuaki
K
Yamanaka
Masahiro
M
Kyo
Masayoshi
M
Okumi
Taigo
T
Kato
Yoichi
Y
Kakuta
Naotsugu
N
Ichimaru
Shiro
S
Takahara
Norio
N
Nonomura
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000473:pathology*; D012189:Retrospective Studies; D013256:Steroids / Q000627:therapeutic use; D014184:Transplantation, Homologous; D055815:Young Adult
D007166:Immunosuppressive Agents; D013256:Steroids
borderline change; interstitial inflammation; renal transplantation