Cancer stem cells in head and neck squamous cell carcinoma.
Recent studies have demonstrated that cancer stem cells (CSC) play an important role in the pathobiology of head and neck squamous cell carcinomas (HNSCC). This subpopulation of undifferentiated, self-renewing cells is responsible for resistance to conventional anti-cancer therapy, cancer recurrence, metastasis and ability to form a heterogeneous tumor. CSC are identified on the basis of specific markers, including membrane proteins or cell enzymes, or by using their self-renewal properties. As their resistance to standard HNSCC treatment may eventually lead to the lack of treatment success, there is an urgent need to better understanding CSC biology and identify them as potential target new treatment modality.
Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Head: prof. dr n. med. Antoni Krzeski, Warsaw, Poland.
Tomasz
T
Szafarowski
Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Head: prof. dr n. med. Antoni Krzeski, Warsaw, Poland; Department of Clinical Immunology, University of Medical Sciences in Poznan, Head: prof. dr n. med. Grzegorz Dworacki, Poznan, Poland. Electronic address: mirski975@gmail.com.
Miroslaw J
MJ
Szczepanski
D014408:Biomarkers, Tumor / Q000502:physiology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*
D014408:Biomarkers, Tumor
Cancer stem cells; HNSCC; Head and neck squamous cell carcinoma; Tumor markers; Tumorigenesis; markery nowotworowe; nowotworowe komórki macierzyste; nowotworzenie; raki głowy i szyi