NIR-responsive upconversion nanoparticles stimulate neurite outgrowth in PC12 cells.
Nerve regeneration is of diagnostic importance in neuroscience in regards to the treatment of degenerative disease. Owing to the ability to release rare-earth ions and produce ROS during upconversion process, upconversion nanoparticles are first reported for promoting neurite outgrowth. Different charged coating materials which play a critical role in cell attachment, can further lead to different effects on cell differentiation.
Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Yijia
Y
Guan
Meng
M
Li
Kai
K
Dong
Jinsong
J
Ren
Xiaogang
X
Qu
D000818:Animals; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002470:Cell Survival; D005452:Fluoresceins / Q000737:chemistry; D049452:Green Fluorescent Proteins / Q000737:chemistry; D007477:Ions; D008855:Microscopy, Electron, Scanning; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D020932:Nerve Growth Factor / Q000737:chemistry; D016501:Neurites / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000187:drug effects*; D016716:PC12 Cells; D011108:Polymers / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species; D019265:Spectroscopy, Near-Infrared
D005452:Fluoresceins; D007477:Ions; D011108:Polymers; D017382:Reactive Oxygen Species; D049452:Green Fluorescent Proteins; D020932:Nerve Growth Factor; C007740:fluorexon
NIR; neurite outgrowth; neuronal differentiation; rare earth elements; upconversion nanoparticles