The effect of the treatment of Helicobacter pylori infection on the glycemic control in type 2 diabetes mellitus.
OBJECTIVE
To evaluate the possible long-term effects of Helicobacter pylori infection on Hemoglobin A1c and fasting blood sugar levels in patients with type 2 diabetes.


BACKGROUND
Helicobacter pylori causes the gastrointestinal tract inflammation, which it plays an important role in distortion of glucose and lipids absorption that altered lipid metabolism and energy harvesting and develops type 2 diabetes, insulin resistance and has been linked to impaired blood glucose.


METHODS
In this clinical trial, patients with type 2 diabetes and confirmed Helicobacter pylori infection were recruited from the endocrinology clinic of the Shahid Beheshti University Tehran, Iran. Before and after 3 months of eradication therapy fasting blood samples were taken and glycalated hemoglobin levels and fasting blood sugar levels were measured.


RESULTS
85 (27 male 31.8%, 58 female 68.2%) patients with the mean age of 52.±4.7 years were recruited. 52 (62%) had successful Helicobacter pylori eradication (16 male, 30.8% and 36 female, 69.2%). The mean glycalated haemoglobin levels before successful treatment was 8.7±1.1 and after treatment was 8.3±0.9 and difference was significant (p<0.001). Mean IgG level of serology was 3.3±1.1 and the correlation with glycalated haemoglobin was significant (p=0.02) (r=0.4).


CONCLUSIONS
Our results indicate that the Helicobacter pylori treatment can improve the mean glycalated haemoglobin in patients with type 2 diabetes. More investigations will be required to evaluate the effects of Helicobacter pylori eradication among different age groups and in relation to obesity status, diabetes and other disease, and it may be beneficial for patients at risk of diabetes to be checked for the presence of Helicobacter pylori infection.
Gastroenterology and Liver Disease Research Cancer, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Homayon
H
Zojaji
Gastroenterology and Liver Disease Research Cancer, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Elnaz
E
Ataei
Gastroenterology and Liver Disease Research Cancer, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Somayeh Jahani
SJ
Sherafat
Gastroenterology and Liver Disease Research Cancer, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Mehdi
M
Ghobakhlou
Gastroenterology and Liver Disease Research Cancer, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Seyed Reza
SR
Fatemi
FBS; Glycemic control; HbA1C; Helicobacter pylori infection; Type 2 diabetes; UBT