Two siblings with Paget's disease of bone.
Paget's disease of bone (PDB) is a chronic disorder characterised by focal areas of excessive osteoclastic bone resorption with a secondary increase in osteoblastic bone formation. First-degree relatives of patients with PDB are at seven times higher risk of developing this disorder, with a tendency towards earlier age at onset. We report two siblings who presented with features of polyostotic Paget's disease. They presented with features of non-inflammatory back pain. Biochemical evaluation was unremarkable except for elevated serum alkaline phosphatase. Subsequently, radiology and bone scans were diagnostic of polyostotic PDB. They were treated with bisphosphonates with which they improved.
Department of Endocrinology & Diabetes, Christian Medical College, Vellore, Tamil Nadu, India.
Dukhabandhu
D
Naik
Christian Medical College, Vellore, Tamil Nadu, India.
Hesargatta Shyamsunder
HS
Asha
Department of ENT, Christian Medical College, Vellore, Tamil Nadu, India.
Suma Susan
SS
Mathews
Christian Medical College, Vellore, Tamil Nadu, India.
Thomas Vizhalil
TV
Paul
D001416:Back Pain / Q000209:etiology; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging*; D011859:Radiography; D011877:Radionuclide Imaging; D035781:Siblings