The global burden of aortic stenosis.
Degenerative, calcific valvular aortic stenosis (AS), caused by an active process of atherosclerosis, calcification and ossification, is the most common cause of AS in industrialized nations. The prevalence of calcific AS is age-dependent, and thus is expected to increase due to demographic aging of the global population. It is well recognized that severe AS carries a poor prognosis if left untreated. Despite this recognition, many patients are inappropriately denied surgery because of perceived risk. This article will examine the etiology, prevalence, and current trends in the treatment of degenerative AS focusing on indications for surgical aortic valve replacement.
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, MN.
Jeremy J
JJ
Thaden
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address: nkomo.vuyisile@mayo.edu.
Vuyisile T
VT
Nkomo
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, MN.
Maurice
M
Enriquez-Sarano
D000367:Age Factors; D000818:Animals; D001021:Aortic Valve / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D002114:Calcinosis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D014943:Global Health; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D018579:Patient Selection; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
Aortic stenosis; Aortic valve replacement; Prevalence