Solvent/detergent plasma: pharmaceutical characteristics and clinical experience.
The solvent/detergent treatment is an established virus inactivation technology that has been industrially applied for manufacturing plasma derived medicinal products for almost 30 years. Solvent/detergent plasma is a pharmaceutical product with standardised content of clotting factors, devoid of antibodies implicated in transfusion-related acute lung injury pathogenesis, and with a very high level of decontamination from transfusion-transmissible infectious agents. Many clinical studies have confirmed its safety and efficacy in the setting of congenital as well as acquired bleeding disorders. This narrative review will focus on the pharmaceutical characteristics of solvent/detergent plasma and the clinical experience with this blood product.
UOC di Immunoematologia e Medicina Trasfusionale e UOC di Patologia Clinica, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy, giancarlo@liumbruno.it.
Giancarlo Maria
GM
Liumbruno
Massimo
M
Franchini
D055371:Acute Lung Injury / Q000517:prevention & control; D016913:Blood Component Transfusion; D003902:Detergents / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D010949:Plasma / Q000737:chemistry / Q000821:virology; D012997:Solvents / Q000009:adverse effects / Q000494:pharmacology*; D038301:Virus Inactivation
D003902:Detergents; D012997:Solvents