Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents.
Podophyllotoxin (PPT), as well as its congeners and derivatives, exhibits pronounced biological activities, especially antineoplastic effects. Its strong inhibitory effect on tumor cell growth led to the development of three of the most highly prescribed anticancer drugs in the world, etoposide, teniposide, and the water-soluble prodrug etoposide phosphate. Their clinical success as well as intriguing mechanism of action stimulated great interest in further modification of PPT for better antitumor activity. The C-4 position has been a major target for structural derivatization aimed at either producing more potent compounds or overcoming drug resistance. Accordingly, numerous PPT derivatives have been prepared via hemisynthesis and important structure-activity relationship (SAR) correlations have been identified. Several resulting compounds, including GL-331, TOP-53, and NK611, reached clinical trials. Some excellent reviews on the distribution, sources, applications, synthesis, and SAR of PPT have been published. This review focuses on a second generation of new etoposide-related drugs and provides detailed coverage of the current status and recent development of C-4-modified PPT analogs as anticancer clinical trial candidates.
School of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
Ying-Qian
YQ
Liu
Jing
J
Tian
Keduo
K
Qian
Xiao-Bo
XB
Zhao
Susan L
SL
Morris-Natschke
Liu
L
Yang
Xiang
X
Nan
Xuan
X
Tian
Kuo-Hsiung
KH
Lee
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011034:Podophyllotoxin
C-4 position; cytotoxic agents; podophyllotoxin; reviews