[Phenotypes of prediabetes and type 2 diabetes].
Type 2 Diabetes is a heterogeneous disease which harbors several different pathomechanistic entities. For a successful prevention, it is important to understand the exact pathomechanisms. Overt type 2 Diabetes usually develops through an intermediary state called prediabetes, which is also heterogeneous. This state is especially important, because it already confers a higher risk for diabetes-associated complications. Therefore, detection of prediabetes and prevention of its progression to diabetes would be desirable. In this review, we describe the phenotypes of prediabetes and type 2 diabetes. We also try to envision the first steps of a future phenotype-oriented diabetes therapy.
Innere Medizin IV, Abteilung für Endokrinologie, Diabetologie, Vaskuläre Medizin, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen.
R
R
Wagner
Innere Medizin IV, Abteilung für Endokrinologie, Diabetologie, Vaskuläre Medizin, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen.
H-U
HU
Häring
Innere Medizin IV, Abteilung für Endokrinologie, Diabetologie, Vaskuläre Medizin, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen.
A
A
Fritsche
D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D048909:Diabetes Complications / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D018450:Disease Progression; D042241:Early Diagnosis; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein