[The path to innovative drug development of cancer vaccine: from discovery of tumor antigens to clinical trials].
Tumor immunology has been advancing after the great discovery of tumor-specific antigen MAGE in 1991, and a number of tumor antigens have been reported to date. We have also found novel tumor antigens through various methodologies such as gene expression cloning, bioinformatics, reverse immunology, transcriptome analysis and peptidome analysis. Recently, we made a success of defining cancer stem cell-specific antigens. The fruits of our basic research have been applied to clinical trials of cancer vaccine. The long path and future perspectives of innovative immunotherapeutic drug development are described.
Department of Pathology 1, Sapporo Medical University School of Medicine.
Toshihiko
T
Torigoe
Yoshihiko
Y
Hirohashi
Tomohide
T
Tsukahara
Takayuki
T
Kanaseki
Vitaly
V
Kochin
Noriyuki
N
Sato
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D019496:Cancer Vaccines; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000628:therapy
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines