Polymorphism of dopamine transporter gene DAT1 and individual variability of defense cardiac response in humans.
We evaluated association of BP stress-reactivity on the model of cardiac defense response in 45-70-year-old men with variable number of tandem repeat polymorphism in genes encoding dopamine transporter protein (DAT1) and serotonin transporter protein (5-HTTLPR). It was found that individuals carrying long allele variant (l) of DAT1 gene (l/l: allele l homozygotes) in the genotype in comparison with short variant (s) carriers (heterozygous genotype l/s) demonstrate hyperreactive profiles of cardiovascular stress reactivity characterized by a significant increase in the amplitude and duration of long-latency BP components in cardiac defensive response.
Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
L I
LI
Aftanas
K V
KV
Loktev
P V
PV
Miroshnikova
V V
VV
Gafarov
E A
EA
Gromova
D000161:Acoustic Stimulation; D000368:Aged; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D004586:Electrophoresis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D020080:Tandem Repeat Sequences / Q000235:genetics
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins