Results of drug correction of structural and functional changes in the gingiva in experimental gastroduodenitis.
Morphological changes in the gingiva under the effect of drugs improving microcirculation were studied in pubertal Wistar rats with experimental gastroduodenitis. Chronic gastroduodenitis was induced by intragastric administration of 50% medical bile (1 ml/100 g body weight daily) for 40 days. The best medical correction was attained with altan and citrarginine. Morphologic studies showed signs of regeneration plastic activity of the epithelium, restructuring of the gingival lamina propria, and enlargement of the vascular bed area. Calcium-D3 Nycomed disordered the regeneration processes in the rat epithelium, because of calcium ion capacity to increase oxygen demand in tissues and cause destructive processes. Hence, pathogenetic drug correction of degenerative processes in the gingiva under conditions of chronic gastroduodenitis should include drugs promoting recovery of the microcirculatory bed, altan and citrarginine.
Dnepropetrovsk Medical Academy, Ministry of Health of Ukraine, Dnepropetrovsk, Ukraine, helenromanenko@mail.ru.
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D000818:Animals; D000880:Anthraquinones / Q000627:therapeutic use*; D001120:Arginine / Q000627:therapeutic use; D001622:Betaine / Q000627:therapeutic use; D001646:Bile / Q000378:metabolism; D019343:Citric Acid / Q000627:therapeutic use; D004382:Duodenitis / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy*; D005881:Gingiva / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000880:Anthraquinones; D019343:Citric Acid; D001622:Betaine; D001120:Arginine; C004315:danthron