Leptin levels and nutritional status of indigenous Tepehuán and Mestizo subjects in Durango, Mexico.
The aim of this study was to assess differences in nutritional status and their association with circulating leptin levels in the indigenous Tepehuán people of Mezquital Durango and Mestizo populations of Durango City, Mexico. A group of 128 volunteers aged 18 through 59 years were recruited for the study: 60 indigenous Tepehuán from Mezquital and 68 Mestizo individuals from Durango City. The classification of nutritional status was through body mass index (BMI). Clinical evaluations, including anthropometry and lipid profiles, were performed to ascertain the health of the participants. Circulating leptin levels were determined in blood samples after at 08 hours of fasting. The healthy subjects were classified according to BMI: 32 Tepehuán and 30 Mestizo subjects were of normal weight (NW), and 28 Tepehuán and 38 Mestizo subjects were overweight or obese (OW/O). Both NW and OW/O Tepehuán subjects showed lower leptin concentrations than the comparable Mestizo subjects. Statistical analysis showed a negative Pearson's correlation (r = -0.5; P < 0.05) between BMI and leptin levels in NW Tepehuán subjects, but no significant correlation was found in other groups. The differences found in Tepehuán compared with Mestizo subjects might be explained by poor nutritional status, which leads to scarce adipose tissue and low levels of leptin synthesis. Leptin concentration and its relationship to BMI are associated with ethnicity.
Centro Interdisciplinario de Investigación para el Desarrollo Regional IPN, Durango, Sigma No. 119, Col. 20 de Noviembre II, 34220 Durango, DGO, Mexico.
Dealmy Delgadillo
DD
Guzmán
Escuela Nacional de Medicina y Homeopatía IPN Guillermo Massieu Helguera, No. 239, Fraccionamiento "La Escalera", Ticoman, 07320 Mexico City, DF, Mexico.
Laurence Annie Marchat
LA
Marchau
Centro de Investigación y de Estudios Avanzados del IPN Avenida Instituto Politécnico Nacional No. 2508, San Pedro Zacatenco, Gustavo A. Madero, 07360 Mexico City, DF, Mexico.
José L
JL
Reyes
Centro Interdisciplinario de Investigación para el Desarrollo Regional IPN, Durango, Sigma No. 119, Col. 20 de Noviembre II, 34220 Durango, DGO, Mexico.
Verónica Loera
VL
Castañeda
Centro Interdisciplinario de Investigación para el Desarrollo Regional IPN, Durango, Sigma No. 119, Col. 20 de Noviembre II, 34220 Durango, DGO, Mexico.
Martha Sosa
MS
Macías
Escuela Nacional de Medicina y Homeopatía IPN Guillermo Massieu Helguera, No. 239, Fraccionamiento "La Escalera", Ticoman, 07320 Mexico City, DF, Mexico.
Jessica García
JG
Vivas
Centro Interdisciplinario de Investigación para el Desarrollo Regional IPN, Durango, Sigma No. 119, Col. 20 de Noviembre II, 34220 Durango, DGO, Mexico ; Instituto Politécnico Nacional, CIIDIR, Durango, Mexico.
Ismael Lares
IL
Asseff
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007198:Indians, North American; D020738:Leptin / Q000097:blood*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000097:blood* / Q000208:ethnology; D055815:Young Adult
D020738:Leptin