Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine , Tokyo , Japan .
Miho
M
Nakamura
Hidetoshi
H
Nakamura
Naoto
N
Minematsu
Shotaro
S
Chubachi
Masaki
M
Miyazaki
Shuichi
S
Yoshida
Keishi
K
Tsuduki
Toru
T
Shirahata
Shuko
S
Mashimo
Saeko
S
Takahashi
Takahiro
T
Nakajima
Hiroki
H
Tateno
Seitaro
S
Fujishima
Tomoko
T
Betsuyaku
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D015851:Interleukin-7 / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D012907:Smoking / Q000097:blood* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
D015415:Biomarkers; D016207:Cytokines; D018793:Interleukin-13; D015848:Interleukin-5; D015850:Interleukin-6; D015851:Interleukin-7; D016753:Interleukin-10
Airflow limitation; chronic obstructive pulmonary disease; emphysema; inflammatory cytokine; plasma biomarker