Reusable, robust, and accurate laser-generated photonic nanosensor.
Developing noninvasive and accurate diagnostics that are easily manufactured, robust, and reusable will provide monitoring of high-risk individuals in any clinical or point-of-care environment. We have developed a clinically relevant optical glucose nanosensor that can be reused at least 400 times without a compromise in accuracy. The use of a single 6 ns laser (λ = 532 nm, 200 mJ) pulse rapidly produced off-axis Bragg diffraction gratings consisting of ordered silver nanoparticles embedded within a phenylboronic acid-functionalized hydrogel. This sensor exhibited reversible large wavelength shifts and diffracted the spectrum of narrow-band light over the wavelength range λpeak ≈ 510-1100 nm. The experimental sensitivity of the sensor permits diagnosis of glucosuria in the urine samples of diabetic patients with an improved performance compared to commercial high-throughput urinalysis devices. The sensor response was achieved within 5 min, reset to baseline in ∼10 s. It is anticipated that this sensing platform will have implications for the development of reusable, equipment-free colorimetric point-of-care diagnostic devices for diabetes screening.
Department of Chemical Engineering and Biotechnology, University of Cambridge , Tennis Court Road, Cambridge CB2 1QT, United Kingdom.
Ali K
AK
Yetisen
Yunuen
Y
Montelongo
Fernando
F
da Cruz Vasconcellos
J L
JL
Martinez-Hurtado
Sankalpa
S
Neupane
Haider
H
Butt
Malik M
MM
Qasim
Jeffrey
J
Blyth
Keith
K
Burling
J Bryan
JB
Carmody
Mark
M
Evans
Timothy D
TD
Wilkinson
Lauro T
LT
Kubota
Michael J
MJ
Monteiro
Christopher R
CR
Lowe