Stereocontrol in Palladium-Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1,5-Enynes and Propargyl Acetates.
Kinetic resolution during the catalytic allyl-propargyl cross-coupling with chiral starting materials can be accomplished with a chiral Palladium catalyst. These reactions offer ready access to enantiomerically enriched enyne products from simple readily available starting materials.
Department of Chemistry, Boston College, Chestnut Hill, MA 02467 (USA).
Michael J
MJ
Ardolino
Department of Chemistry, Boston College, Chestnut Hill, MA 02467 (USA).
Meredith S
MS
Eno
Department of Chemistry, Boston College, Chestnut Hill, MA 02467 (USA).
James P
JP
Morken
Allylation; Asymmetric Catalysis; Asymmetric Synthesis; Boron; Palladium