[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.
The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.
Institute for Lung Health, Department of Infection, Immunity and Inflammation, NIHR Biomedical Unit, Glenfield Hospital, University of Leicester, Leicester, UK; Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK.
David
D
Sweeney
Fay
F
Hollins
Edith
E
Gomez
Ruth
R
Saunders
R A John
RA
Challiss
Christopher E
CE
Brightling
D000328:Adult; D000368:Aged; D001249:Asthma / Q000503:physiopathology*; D001706:Biopsy; D002110:Caffeine / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D009568:Nitrendipine / Q000494:pharmacology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D012720:Severity of Illness Index; D014700:Verapamil / Q000494:pharmacology; D014797:Vital Capacity / Q000502:physiology
D002110:Caffeine; D009568:Nitrendipine; D014700:Verapamil
airway hyperresponsiveness; airway smooth muscle; asthma; calcium; oscillations