MicroRNAs: potential therapeutic targets in diabetic complications of the cardiovascular and renal systems.
Diabetes mellitus is a serious health problem that can lead to several pathological complications in numerous organs and tissues. The most important and most prevalent organs affected by this disease are the heart and the kidneys, and these complications are the major causes of death in patients with diabetes. MicroRNAs (miRNAs), short non-coding RNAs, have been found to be functionally important in the regulation of several pathological processes, and they are emerging as an important therapeutic tool to avoid the complications of diabetes mellitus. This review summarizes the knowledge on the effects of miRNAs in diabetes. The use of miRNAs in diabetes from a clinical perspective is also discussed, focusing on their potential role to repair cardiovascular and renal complications.
Centro de Ciências da Saúde, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Laboratório Integrado de Ciências Morfofuncionais, Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
M F
MF
Figueira
G
G
Monnerat-Cahli
E
E
Medei
A B
AB
Carvalho
M M
MM
Morales
M E
ME
Lamas
R N
RN
da Fonseca
J
J
Souza-Menezes
D000818:Animals; D058065:Diabetic Cardiomyopathies / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D003930:Diabetic Retinopathy / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D005786:Gene Expression Regulation; D005819:Genetic Markers; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D034622:RNA Interference
D005819:Genetic Markers; D035683:MicroRNAs; D016376:Oligonucleotides, Antisense
cardiomyopathy; diabetes; hyperglycaemia; miRNAs; nephropathy