Whither pharmacometrics?: present state and future choices.
The theme of this month's issue of Clinical Pharmacology & Therapeutics is pharmacometrics. When looking back at the early days of pharmacometrics, current contributions to the drug development process look impressive. The questions are whether the original promise is being kept and how the impact can become even greater.
Pharmacokinetics, Dynamics and Metabolism, Pfizer, San Diego, California, USA.
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Vicini
Medical Sciences Biostatistics, Amgen, Thousand Oaks, California, USA.
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Smith
D003198:Computer Simulation; D007880:Legislation, Drug; D015233:Models, Statistical; D010600:Pharmacology / Q000592:standards* / Q000639:trends*; D014894:Weights and Measures