Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study.
Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Perry T C
PT
van Doormaal
Unit of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy.
Nicola
N
Ticozzi
Unit of Genetics of Neurodegenerative and Metabolic Diseases, IRCCS Carlo Besta Neurological Institute, Milan, Italy.
Cinzia
C
Gellera
Unit of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy.
Antonia
A
Ratti
Unit of Genetics of Neurodegenerative and Metabolic Diseases, IRCCS Carlo Besta Neurological Institute, Milan, Italy.
Franco
F
Taroni
'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Adriano
A
Chiò
'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Andrea
A
Calvo
ALS Center, Salvatore Maugeri Foundation, IRCSS, Milan, Italy.
Gabriele
G
Mora
Laboratory of Molecular Genetics, Città della Salute e della Scienza Hospital, Turin, Italy.
Gabriella
G
Restagno
Neuromuscular Diseases Research Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Bryan J
BJ
Traynor
The Institute of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Anna
A
Birve
Leuven Institute for Neurodegenerative Disorders (LIND), University of Leuven, Leuven, Belgium; Vesalius Research Center Center (VRC), Flanders Institute for Biotechnology (VIB), Leuven, Belgium; Department of Clinical and Experimental Neurology, University Hospital Leuven, University of Leuven, Leuven, Belgium.
Robin
R
Lemmens
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Michael A
MA
van Es
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Christiaan G J
CG
Saris
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Hylke M
HM
Blauw
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Paul W J
PW
van Vught
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Ewout J N
EJ
Groen
Department of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy.
Lucia
L
Corrado
Department of Neurology, A. Avogadro University and Maggiore della Carità Hospital, Novara, Italy.
Letizia
L
Mazzini
Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy; Neurologic Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Roberto
R
Del Bo
Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy; Neurologic Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Stefania
S
Corti
Department of Neurology, University of Ulm, Ulm, Germany.
Stefan
S
Waibel
Department of Neurology, Charité University Hospital, Humboldt-University, Berlin, Germany.
Thomas
T
Meyer
Department of Neurology, University of Ulm, Ulm, Germany.
Albert C
AC
Ludolph
Leuven Institute for Neurodegenerative Disorders (LIND), University of Leuven, Leuven, Belgium; Laboratory for Neuroimmunology, Section for Experimental Neurology, KU Leuven, Leuven, Belgium.
An
A
Goris
Leuven Institute for Neurodegenerative Disorders (LIND), University of Leuven, Leuven, Belgium; Vesalius Research Center Center (VRC), Flanders Institute for Biotechnology (VIB), Leuven, Belgium; Department of Clinical and Experimental Neurology, University Hospital Leuven, University of Leuven, Leuven, Belgium.
Philip
P
van Damme
Leuven Institute for Neurodegenerative Disorders (LIND), University of Leuven, Leuven, Belgium; Vesalius Research Center Center (VRC), Flanders Institute for Biotechnology (VIB), Leuven, Belgium; Department of Clinical and Experimental Neurology, University Hospital Leuven, University of Leuven, Leuven, Belgium.
Wim
W
Robberecht
Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, UK.
Aleksey
A
Shatunov
Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, UK.
Isabella
I
Fogh
The Institute of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Peter M
PM
Andersen
Department of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy.
Sandra
S
D'Alfonso
Trinity College Institute of Neurosciences, Trinity College, Dublin, Ireland; Department of Neurology, Beaumont Hospital, Dublin, Ireland.
Orla
O
Hardiman
Department of Neurology, Beaumont Hospital, Dublin, Ireland; Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Simon
S
Cronin
Department of Psychiatry, University of Halle, Halle, Germany.
Dan
D
Rujescu
Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, UK.
Ammar
A
Al-Chalabi
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
John E
JE
Landers
Unit of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy.
Vincenzo
V
Silani
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
Leonard H
LH
van den Berg
Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands. Electronic address: j.h.veldink@umcutrecht.nl.
Jan H
JH
Veldink
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000401:mortality*; D015331:Cohort Studies; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016019:Survival Analysis
D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; C484407:KIFAP3 protein, human
Amyotrophic lateral sclerosis; Genome-wide association study; KIFAP3; Kinesin-associated protein 3 gene