Association of the 389 C/T polymorphism of the catalase gene with susceptibility to vitiligo: a meta-analysis.
BACKGROUND
The 389 C/T polymorphism in the catalase gene, CAT, has been reported to be associated with the risk of vitiligo.


OBJECTIVE
To evaluate the association of the CAT 389 C/T polymorphism with susceptibility to vitiligo.


METHODS
We undertook a literature search and included the relevant studies passing the selection criteria. After the relevant data were extracted from each study, we statistically analysed the strength of association between the CAT gene and vitiligo risk.


RESULTS
In total, 7 relevant studies were identified, comprising 1531 patients with vitiligo and 1608 controls. The genotype distribution in the controls of all studies complied with Hardy-Weinberg equilibrium. After pooling all studies, the results indicated that the 389 C/T polymorphisms in CAT were not associated with the risk of vitiligo in Asians and Turks; however the CT genotype might be a genetic risk factor for susceptibility to vitiligo (OR = 1.77, 95% CI 1.30-2.43, P < 0.001) and the CC genotype might decrease the risk of vitiligo (OR = 0.63, 95% CI 0.47-0.86, P < 0.01) in western Europeans.


CONCLUSIONS
The 389 C/T polymorphisms in the CAT gene may be associated with vitiligo in western Europeans. Further studies with larger sample sizes are warranted to confirm our findings.
Department of Physiology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China.
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D002374:Catalase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D014820:Vitiligo / Q000201:enzymology / Q000235:genetics*; D044465:White People / Q000235:genetics
D002374:Catalase