Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population.
OBJECTIVE
Genetic risk variants for type 2 diabetes; rs391300-G in SRR and rs17584499-T in PTPRD, have been identified by a genome-wide association study using Han Chinese individuals living in Taiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the Japanese, we carried out a replication study for the association of the two single nucleotide polymorphisms (SNPs) with type 2 diabetes in a Japanese population.


METHODS
We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNPs with type 2 diabetes by logistic regression analysis.


RESULTS
Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300-G: odds ratio [OR] = 0.97; 95% confidence interval [CI] 0.91-1.04; P = 0.44; rs17584499-T: OR = 1.04; 95% CI 0.96-1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index (BMI) did not affect the association of these variants with the disease. We did not observe a significant association of the SNPs with any metabolic traits, BMI, fasting plasma glucose, homeostasis model assessment of β-cell function (HOMA-β) and HOMA of insulin resistance (HOMA-IR) (P > 0.05).


CONCLUSIONS
Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the Japanese population.
Laboratory for Endocrinology and Metabolism RIKEN Center for Genomic Medicine Yokohama Japan.
Minako
M
Imamura
First Department of Internal Medicine Toyama Japan ; Community Medical Support Unit, Faculty of Medicine University of Toyama Toyama Japan.
Minoru
M
Iwata
Department of Medicine Shiga University of Medical Science Otsu Shiga Japan.
Hiroshi
H
Maegawa
Department of Medicine, Metabolism and Endocrinology School of Medicine Tokyo Japan ; Sportology Center Graduate School of Medicine, Juntendo University Tokyo Japan.
Hirotaka
H
Watada
Health Center Keio University School of Medicine Tokyo Japan.
Hiroshi
H
Hirose
Division of Metabolism and Endocrinology, Department of Internal Medicine St. Marianna University School of Medicine Kawasaki Kanagawa Japan.
Yasushi
Y
Tanaka
First Department of Internal Medicine Toyama Japan.
Kazuyuki
K
Tobe
Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine Kawasaki Medical School Kurashiki Okayama Japan.
Kohei
K
Kaku
Department of Medicine Shiga University of Medical Science Otsu Shiga Japan.
Atsunori
A
Kashiwagi
Department of Diabetes and Metabolic Diseases Graduate School of Medicine, The University of Tokyo Tokyo Japan.
Takashi
T
Kadowaki
Sportology Center Graduate School of Medicine, Juntendo University Tokyo Japan.
Ryuzo
R
Kawamori
Laboratory for Endocrinology and Metabolism RIKEN Center for Genomic Medicine Yokohama Japan.
Shiro
S
Maeda
Genetic association studies; Japanese; Type 2 diabetes mellitus