The Hippo signaling pathway in stem cell biology and cancer.
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.
Department of Pharmacology and Moores Cancer Center, University of California, San Diego La Jolla, CA, USA.
Jung-Soon
JS
Mo
Department of Pharmacology and Moores Cancer Center, University of California, San Diego La Jolla, CA, USA.
Hyun Woo
HW
Park
Department of Pharmacology and Moores Cancer Center, University of California, San Diego La Jolla, CA, USA kuguan@ucsd.edu.
Kun-Liang
KL
Guan
D047108:Embryonic Development / Q000502:physiology*; D000090683:Hippo Signaling Pathway; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*; D009420:Nervous System / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D012867:Skin / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*
D043562:Receptors, G-Protein-Coupled; D017346:Protein Serine-Threonine Kinases
Hippo pathway; YAP; cancer; regeneration; stem cell