Gout patients have an increased risk of developing most cancers, especially urological cancers.
OBJECTIVE
Inflammation and hyperuricaemia, which are the major characteristics of gout disease, are thought to be associated with carcinogenesis and anti-carcinogenesis, respectively. Therefore, we aimed to explore the causal effect on cancers from those with gout disease.


METHODS
New gout patients without a history of cancer were included from 1998 to 2000, and they had been followed up from 2001 to 2008 to observe the incidence of cancers from national outpatient records in Taiwan.


RESULTS
A total of 8408 male gout patients and 25,010 male controls were included by matching gout patients' age and year and month of first diagnosis during the including period. The mean ages at diagnosis were 51.03 ± 14.52 and 50.90 ± 14.45 years for gout patients and controls, respectively. The overall incidence of all cancers was 9.82 cases per 1000 person-years among gout patients compared to 4.35 cases per 1000 person-years among controls after 8 years of follow-up. The age-adjusted standardized incidence ratios (SIRs) were 2.26 [95% confidence interval (CI) 2.06-2.49], 3.31 (95% CI 2.55-4.31), 3.14 (95% CI 2.12-4.64), and 2.18 (95% CI 1.34-3.56) for all cancers, prostate cancer, bladder cancer, and renal cancer, respectively. The cumulative hazard ratios (HRs) were significantly higher in gout patients than in controls with regard to developing prostate, bladder, and renal cancers (all p < 0.001).


CONCLUSIONS
This study shows that gout patients are more likely to develop most cancers, especially the urological cancers: prostate, bladder, and renal cancers. The data also support the hypothesis of a link between metabolic syndrome (MetS) and cancer disorders.
Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine , Kaohsiung , Taiwan.
C-J
CJ
Chen
J-H
JH
Yen
S-J
SJ
Chang
D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D006073:Gout / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D033461:Hyperuricemia / Q000503:physiopathology; D015994:Incidence; D007249:Inflammation / Q000503:physiopathology; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000503:physiopathology; D014571:Urologic Neoplasms / Q000453:epidemiology* / Q000503:physiopathology