A Network Map of FGF-1/FGFR Signaling System.
Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Deregulation of FGF-1 signaling is not only implicated in tumorigenesis but also is associated with tumor invasion and metastasis. Given the biomedical significance of FGFs and the fact that individual FGFs have different roles in diverse physiological processes, the analysis of signaling pathways induced by the binding of specific FGFs to their cognate receptors demands more focused efforts. Currently, there are no resources in the public domain that facilitate the analysis of signaling pathways induced by individual FGFs in the FGF/FGFR signaling system. Towards this, we have developed a resource of signaling reactions triggered by FGF-1/FGFR system in various cell types/tissues. The pathway data and the reaction map are made available for download in different community standard data exchange formats through NetPath and NetSlim signaling pathway resources.
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Rajesh
R
Raju
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India ; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
Shyam Mohan
SM
Palapetta
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Varot K
VK
Sandhya
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India ; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
Apeksha
A
Sahu
Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
Abbas
A
Alipoor
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Lavanya
0000-0001-6237-4962
L
Balakrishnan
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Jayshree
J
Advani
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Bijesh
B
George
Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
K Ramachandra
KR
Kini
Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
N P
NP
Geetha
Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
H S
HS
Prakash
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
T S Keshava
TS
Prasad
Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Yu-Jung
0000-0002-4781-0946
YJ
Chang
Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
Linyi
0000-0001-7258-8817
L
Chen
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Akhilesh
A
Pandey
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Harsha
H
Gowda