Immune diseases caused by mutations in kinases and components of the ubiquitin system.
The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.
MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.
Philip
P
Cohen
D006801:Humans; D007154:Immune System Diseases / Q000235:genetics*; D009154:Mutation; D010766:Phosphorylation / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D054875:Ubiquitination / Q000235:genetics
D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases