Triterpene saponins from the stems of Entada phaseoloides.
Ten new triterpene saponins (1-10) have been isolated from the stems of Entada phaseoloides. Their structures were elucidated by spectroscopic analysis and chemical methods. Among these compounds, the aglycons of 6-10 are being reported for the first time, in this study, including 3β,15α,16α-trihydroxy-11α,12α-epoxy olean-28,13β-olide (6), 3β,15α,16α-trihydroxy-11-oxo-olean-12-en-28-oic acids (7 and 8), and 3β,15α,16α-trihydroxy-oleana-11,13(18)-dien-28-oic acids (9 and 10). The cytotoxic activities of all of these compounds were evaluated against HepG-2, A549, and Ec-1 cell lines.
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
Hui
H
Xiong
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
Xin
X
Ding
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
Xin-Zhou
XZ
Yang
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
Guang-Zhong
GZ
Yang
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
Zhi-Nan
ZN
Mei
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D012503:Saponins; D014315:Triterpenes; D009828:Oleanolic Acid