Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years.
Aim. To determine trace element status and aetiologic factors for development of trace elements deficiencies in children with iron-deficiency anaemia (IDA) aged 0 to 3 years. Contingent and Methods. 30 patients of the University Hospital, Pleven, Bulgaria-I group; 48 patients of the Sumy Regional Child's Clinical Hospital, Sumy, Ukraine-II group; 25 healthy controls were investigated. Serum concentrations of iron, zinc, copper, chromium, cobalt, and nickel were determined spectrophotometrically and by atomic absorption spectrophotometry. Results. Because the obtained serum levels of zinc, copper, and chromium were near the lower reference limits, I group was divided into IA and IB. In IA group, serum concentrations were lower than the reference values for 47%, 57%, and 73% of patients, respectively. In IB group, these were within the reference values. In II group, results for zinc, cobalt, and nickel were significantly lower (P < 0.05), and results for copper were significantly higher in comparison to controls. Conclusion. Low serum concentrations of zinc, copper, cobalt, and nickel were mainly due to inadequate dietary intake, malabsorption, and micronutrient interactions in both studied groups. Increased serum copper in II group was probably due to metabolic changes resulting from adaptations in IDA. Data can be used for developing a diagnostic algorithm for IDA.
Department of Chemistry and Biochemistry & Physics and Biophysics, University of Medicine-Pleven, 1 Kliment Ohridski Street, 5800 Pleven, Bulgaria.
Maria Georgieva
MG
Angelova
Department of Pediatrics, University of Medicine-Pleven, 1 Kliment Ohridski Street, 5800 Pleven, Bulgaria.
Tsvetelina Valentinova
TV
Petkova-Marinova
Department of Hygiene and Ecology, Sumy State University, Medical Institute, 31 Sanatornaya Street, Sumy 40007, Ukraine.
Maksym Vladimirovich
MV
Pogorielov
Department of Pediatrics with Medical Genetics, Sumy State University, Medical Institute, 31 Sanatornaya Street, Sumy 40007, Ukraine.
Andrii Nikolaevich
AN
Loboda
Department of Pediatrics, University of Medicine-Pleven, 1 Kliment Ohridski Street, 5800 Pleven, Bulgaria.
Vania Nedkova
VN
Nedkova-Kolarova
Department of Chemistry and Biochemistry & Physics and Biophysics, University of Medicine-Pleven, 1 Kliment Ohridski Street, 5800 Pleven, Bulgaria.
Atanaska Naumova
AN
Bozhinova