A practical source of chlorodifluoromethyl radicals. Convergent routes to gem-difluoroalkenes and -dienes and (2,2-difluoroethyl)-indoles, -azaindoles, and -naphthols.
The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.
Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique , 91128 Palaiseau, Cedex, France.
Pierre
P
Salomon
Samir Z
SZ
Zard