Reversal of a rocuronium-induced grade IV anaphylaxis via early injection of a large dose of sugammadex.
OBJECTIVE
To report rapid recovery from grade IV rocuronium-induced anaphylaxis with a large dose of sugammadex administered early after the onset of symptoms.


METHODS
A 22-yr-old female without relevant medical history developed an anaphylactic reaction within three minutes of rocuronium injection at induction of anesthesia for a routine cholecystectomy. During the first six minutes, she was unresponsive to usual treatment and her condition evolved to a grade IV anaphylaxis reaction despite a cumulated dose of epinephrine 0.7 mg. Sugammadex 14 mg·kg(-1), injected six minutes after rocuronium, resulted in total resolution of all manifestations of anaphylaxis within three minutes. The patient was discharged from hospital the next day. Allergy investigations confirmed rocuronium as the cause of anaphylaxis.


CONCLUSIONS
Very early administration of a large dose of sugammadex may be an effective treatment for rocuronium-induced anaphylaxis.
Département « Anesthésie -Douleur », Centre Hospitalier Régional Universitaire de Caremeau, Nîmes, Faculté de Médecine Montpellier-Nîmes, Université Montpellier I, Montpellier, France.
Benjamin
B
Conte
Lana
L
Zoric
Gerard
G
Bonada
Bertrand
B
Debaene
Jacques
J
Ripart
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy*; D000732:Androstanols / Q000008:administration & dosage / Q000009:adverse effects*; D002763:Cholecystectomy / Q000379:methods; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects; D000077123:Rocuronium; D000077122:Sugammadex; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium; D004837:Epinephrine