Serum β-nerve growth factor concentrations in pregnant female, nonpregnant female, and male cynomolgus monkeys.
Serum β-nerve growth factor (NGF) concentrations were determined in pregnant female, nonpregnant female, and male cynomolgus monkeys using a highly selective and sensitive immunoaffinity liquid chromatography-tandem mass spectrometry assay. NGF was significantly higher in pregnant monkeys than in nonpregnant female and male monkeys. NGF increased over pregnancy (mean NGF±SD: 541±448, 1590±520, and 3560±1430 pg/ml during the first, second, and third trimesters, respectively). These data will aid in further understanding the role of NGF during pregnancy.
Pfizer Inc., Pharmacokinetics Dynamics and Metabolism, Andover, Massachusetts.
Hendrik
H
Neubert
Pfizer Inc., Pharmacokinetics Dynamics and Metabolism, Groton, Connecticut.
Tracey H
TH
Clark
Pfizer Inc., Clinical Statistics, San Diego, California, USA.
Shibing
S
Deng
Pfizer Inc., Pharmacokinetics Dynamics and Metabolism, Groton, Connecticut.
Susan I
SI
Hurst