The concentration of serum zinc in celiac patients compared to healthy subjects in Tehran.
OBJECTIVE
This study evaluated serum levels of zinc in patient with CD compare to healthy subjects.


BACKGROUND
Celiac disease (CD) is characterized by small intestinal malabsorption of nutrients as a consequence of ingestion of wheat gluten. Zinc is an essential trace element that it has vital biological functions.


METHODS
Sera of 30 celiac cases and 30 healthy normal cohorts as control group were obtained. Atomic absorption spectrophotometer was employed for estimating serum zinc level.


RESULTS
Zinc concentrations in patients diagnosed with CD were significantly lower than healthy subjects (75.97±12 compared with 92.83±18, P-value < 0.0001).


CONCLUSIONS
The result of this study shows that serum zinc concentration is decreased in celiac patients compare to healthy controls. Serum zinc may thus be a marker of CD in adults presenting with gastrointestinal symptoms.
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Fariba
F
Fathi
Department of Chemistry, Tarbiat Modares University, Tehran, Iran.
Fatemeh
F
Ektefa
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Mohsen
M
Tafazzoli
Department of Gastroenterology, Luton & Dunstable Hospital NHS Foundation Trust, Luton, UK.
Kamran
K
Rostami
Gastroenterology and Liver diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad
M
Rostami Nejad
Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Mohsen
M
Fathi
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mostafa
M
Rezaei-Tavirani
Department of Basic Science, Faculty of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Afsaneh Arefi
AA
Oskouie
Gastroenterology and Liver diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Reza
MR
Zali
Atomic absorption spectrophotometer; Celiac disease; Zinc