Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis.
Hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumour progression and metastasis. However, the association between HIF-1α and clinicopathological characteristics of epithelial ovarian cancers is controversial. We searched articles on the association between HIF-1α expression and clinicopathological variables of epithelial ovarian cancer in Cochrane Library, Pubmed, Web of Knowledge and China National Knowledge Infrastructure (CNKI) from inception to February 2014. Twenty-five studies were included in the final review. The expression of HIF-1α in cancer or borderline tissue was significantly higher than that in benign tissue (cancer vs. benign, odds ratio (OR) = 9.73 (95 % confidence interval (CI), 4.90, 19.32); P < 0.00001; borderline vs. benign, OR = 6.29 (95 % CI, 2.69-14.73); P < 0.0001; cancer vs. borderline, OR = 2.31 (95 % CI, 1.04, 5.09); P = 0.04). The expression of HIF-1α in stages III-IV or lymph node metastasis was significantly higher than that in stages I-II or that without lymph node metastasis, respectively (OR = 3.01 (95 % CI, 1.92-4.74); P < 0.00001; OR = 5.20 (95 % CI, 2.10-12.89); P = 0.0004). HIF-1α was associated with histological grade of cancer (grades 3 vs. 1, OR = 4.52 (95 % CI, 2.79-7.31); P < 0.00001; grades 3 vs. 2, OR = 2.02 (95 % CI, 1.27-3.19); P = 0.003; grades 3 vs. 1, OR = 2.43 (95 % CI), 1.65-3.59; P < 0.00001) and lower 5-year survival rates (OR = 11.46 (95 % CI, 3.43-38.29); P < 0.0001). However, histological types and the age of patients were not associated with HIF-1α expression (OR = 1.01 (95 % CI, 0.72, 1.42); P = 0.94; OR = 1.06 (95 % CI, 0.73-1.55); P = 0.75). In conclusion, HIF-1α is related to the malignant degree, FIGO stage, histological grade, lymph node metastasis and 5-year survival rate of epithelial ovarian cancer. It may play an important role in clinical treatment and prognostic evaluation.
Department of Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.
Yue
Y
Jin
Haolu
H
Wang
Xiaowen
X
Liang
Jun
J
Ma
Yu
Y
Wang
D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology*; D008207:Lymphatic Metastasis; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000401:mortality / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology*; D011379:Prognosis
D051795:Hypoxia-Inducible Factor 1, alpha Subunit