Chiral magnesium(II)-catalyzed asymmetric ring-opening of meso-aziridines with primary alcohols.
The asymmetric ring-opening of meso-aziridines with primary alcohols is realized using an N,N'-dioxide-Mg(OTf)2 complex as the catalyst. The desired vicinal trans-β-amino ethers are afforded in good yields and enantioselectivities. Aniline and water could also be used as the nucleophiles for the ring-opening in an identical catalyst system.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn.
Jun
J
Li
Yuting
Y
Liao
Yulong
Y
Zhang
Xiaohua
X
Liu
Lili
L
Lin
Xiaoming
X
Feng