Lipid target achievement among patients with very high and high cardiovascular risk in a lipid clinic.
This was a retrospective study that assessed achievement of lipid-lowering treatment targets in the setting of a University Hospital Lipid Clinic. Low-density lipoprotein cholesterol (LDL-C) goal attainment according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines was recorded in 1000 consecutive adult patients followed for ≥3 years (mean 8 years). The LDL-C targets according to the NCEP ATP III were attained by 66% and 86% of patients with "very high" (n = 477) and "high" (n = 408) cardiovascular risk, respectively. Fewer patients were within LDL-C goals according to the ESC/EAS guidelines: 25% and 42%. Overall, 92% of the patients were on statins: 67% were on statin monotherapy, while 33% were on combinations with ezetimibe (25%), ω-3 fatty acids (5%), fibrates (4%), or colesevelam (2%). Even in a specialist lipid clinic, a large proportion of patients are not at goal according to the recent ESC/EAS guidelines.
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
Fotios
F
Barkas
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece vaglimp@yahoo.com.
Evangelos N
EN
Liberopoulos
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
Michael S
MS
Kostapanos
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
George
G
Liamis
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
Dimitrios
D
Tziallas
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
Moses
M
Elisaf
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood*; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006115:Greece; D019983:Guideline Adherence; D006785:Hospitals, University; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents
cardiovascular disease; dyslipidemia; guidelines; high risk; lipid clinic; low-density lipoprotein cholesterol; treatment target