Synthesis, characterization, theoretical study and biological activities of oxovanadium (IV) complexes with 2-thiophene carboxylic acid hydrazide.
Oxovanadium (IV) complexes (1)-(3) have been synthesized by treating 2-thiophene carboxylic acid hydrazide with VOSO4⋅xH2O and VCl3(THF)3 in different M/L ratios. These complexes have been characterized by elemental analysis, UV-vis, FT-IR and mass spectrometry. The FT-IR data predicts the bidentate nature of the ligand which is also confirmed by semi-empirical study. Mass spectrometric data shows that molecular ion peak is only observed for 2-thiophene carboxylic acid hydrazide. The ESP map and thermodynamic parameters shows the presence of partial charge on atoms and stability of synthesized oxovanadium complexes, respectively. DNA binding study of complexes (1)-(3) was carried out by UV-vis and cyclic voltammetric methods which suggests the intercalative binding mode of the complexes with DNA. Cytotoxicity was checked by brine shrimp lethality assay and complex (1) showed greater cytotoxicity towards Artemia salina as compared to free ligand. Immuno-modulatory activity data shows that hydrazide ligand was more active as compared to oxovanadium complexes and standard drug. Complex (2) shows significant urease inhibition activity. The ligand and synthesized complexes were found inactive against all tested bacterial and fungal strains.
Department of Chemistry, GC University, Faisalabad, Pakistan.
Mudassir
M
Jabeen
Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan. Electronic address: drsa54@yahoo.com.
Saqib
S
Ali
Department of Chemistry, GC University, Faisalabad, Pakistan. Electronic address: sairashahzadi@hotmail.com.
Saira
S
Shahzadi
Department of App. Sci. and Hum., Faculty of Engg. and Tech., Mody Institute of Technology and Science (Deemed University), Lakshmangargh, 332311 Sikar, Raj., India.
Saroj K
SK
Sharma
Department of App. Sci. and Hum., Faculty of Engg. and Tech., Mody Institute of Technology and Science (Deemed University), Lakshmangargh, 332311 Sikar, Raj., India.
Kushal
K
Qanungo
D000818:Animals; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D004247:DNA / Q000737:chemistry; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D007155:Immunologic Factors / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008968:Molecular Conformation; D017550:Spectroscopy, Fourier Transform Infrared; D013876:Thiophenes / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors / Q000378:metabolism; D017968:Vanadium Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity
D056831:Coordination Complexes; D007155:Immunologic Factors; D013876:Thiophenes; D017968:Vanadium Compounds; C016144:thiophene-2-carboxylic acid hydrazide; D004247:DNA; D014510:Urease
Biological activities; Conductance; Cyclic voltammetry; DNA binding study; Oxovanadium (IV) complexes; Semi-empirical study; Spectroscopy