Nickel-catalyzed α-arylation of ketones with phenol derivatives.
The nickel-catalyzed α-arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α-arylketones. For this transformation, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt) was identified as a new, enabling, air-stable ligand for this transformation. The intermediate of an assumed C-O oxidative addition was isolated and characterized by X-ray crystal-structure analysis.
Institute of Transformative Bio-Molecules (WPI-ITbM) an Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602 (Japan).
Ryosuke
R
Takise
Kei
K
Muto
Junichiro
J
Yamaguchi
Kenichiro
K
Itami
D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D007659:Ketones / Q000737:chemistry*; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D019800:Phenol / Q000737:chemistry*
D056831:Coordination Complexes; D007659:Ketones; D019800:Phenol; D002244:Carbon; D009532:Nickel; D010100:Oxygen
CO activation; nickel; oxidative addition; synthetic methods; α-arylation