Cellular metabolism modulation in T lymphocyte immunity.
T lymphocytes are a central component, and play an important role in controlling immunity and immunological diseases. Recent studies have shown that T cell metabolism is highly dynamic and has a tremendous impact on the modulation of T lymphocyte immunity. Specific metabolic pathways meet energy and biosynthetic requirements that can support specific T cell functional activities in immunity and immunological diseases. This review summarizes the recent progresses about the modulatory role of cell metabolism in T cell development, differentiation, activation and function in immunity. These might provide new opportunities to modulate the immune responses and treat clinical immunological diseases. This article is protected by copyright. All rights reserved.
Department of Immunology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences; Biotherapy Research Center, Institute of Immunobiology, Fudan University, Shanghai, China; Department Liver Surgery and Liver Transplantation, Shanghai Jiao-tong University School of Medicine Renji Hospital, Shanghai, China.
Huanrong
H
Liu
Hui
H
Yang
Xi
X
Chen
Yun
Y
Lu
Zhengguo
Z
Zhang
Jian
J
Wang
Ming
M
Zhang
Lixiang
L
Xue
Feng
F
Xue
Guangwei
G
Liu

mTOR
; Amino acid; Glycosis; HIF1α; Metabolism; T cell development; TH1 cells; Treg; c-myc; fatty acid