Combination therapy in the treatment of experimental invasive fungal infection by Sarocladium (Acremonium) kiliense.
Since human infections by Sarocladium (Acremonium) kiliense are usually refractory to antifungal therapy, combinations of drugs are an option that needs exploring. The antifungal activities of anidulafungin plus posaconazole or voriconazole and of amphotericin B plus voriconazole were evaluated and their efficacy was tested in a murine model of disseminated infection by three S. kiliense strains. The results showed that although efficacy was strain-dependent, these combinations work better, in general, than monotherapies. The best results were obtained with the combination of anidulafungin plus posaconazole, although the in vitro assay showed indifference or an antagonistic effect.
Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Fabiola
F
Fernández-Silva
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Javier
J
Capilla
Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Emilio
E
Mayayo
Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
Deanna
D
Sutton
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain. Electronic address: josep.guarro@urv.cat.
Josep
J
Guarro
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000379:methods; D006999:Hypocreales / Q000187:drug effects* / Q000302:isolation & purification*; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology*; D016019:Survival Analysis; D016896:Treatment Outcome
D000935:Antifungal Agents
Animal model; Antifungal combinations; Fungal infection; Sarocladium kiliense