Synthesis, discovery, and quantitation of dihomo-isofurans: biomarkers for in vivo adrenic acid peroxidation.
The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.
Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247-Universités de Montpellier I et II, ENSCM, Faculté de Pharmacie, 15 Av. Charles Flahault, 34093 Montpellier cedex 05 (France).
Aurélien
A
de La Torre
Yiu Yiu
YY
Lee
Camille
C
Oger
Per Torp
PT
Sangild
Thierry
T
Durand
Jetty Chung-Yung
JC
Lee
Jean-Marie
JM
Galano
D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015227:Lipid Peroxidation
D005231:Fatty Acids, Unsaturated; D005663:Furans; C011395:adrenic acid
biomarkers; lipids; mass spectrometry; oxidation; total synthesis