Direct assembly of 3,4-difunctionalized benzofurans and polycyclic benzofurans by phenol dearomatization and palladium-catalyzed domino reaction.
A method to directly convert 2-alkynylphenols to 3,4-difunctionalized benzofurans and polycyclic benzofurans was developed. This protocol involves a hypervalent-iodine-mediated oxidative dearomatization to break the aromaticity of 2-alkynylphenols, and a palladium-catalyzed domino reaction to install two functional groups at the C3 and the C4 positions and restore the aromaticity of benzofurans.
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China).
Zhaomeng
Z
Han
Liang
L
Zhang
Zhiming
Z
Li
Renhua
R
Fan
benzofurans; dearomatization; domino reactions; multicomponent reactions; phenols