Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?
Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials.


CONCLUSIONS
SpO2 of 85-89% can increase mortality and 91-95% can cause hyperoxia and ill effects. Neither of these ranges can be recommended, and wider intermediate targets, such as 87-94% or 88-94%, may be safer.
Ibero American Society of Neonatology (SIBEN), Dana Point, CA, USA; New York Medical College, Valhalla, NY, USA.
Augusto
A
Sola
Sergio G
SG
Golombek
María Teresa
MT
Montes Bueno
Lourdes
L
Lemus-Varela
Claudia
C
Zuluaga
Fernando
F
Domínguez
Hernando
H
Baquero
Alejandro E
AE
Young Sarmiento
Diego
D
Natta
Jose M
JM
Rodriguez Perez
Richard
R
Deulofeut
Ana
A
Quiroga
Gabriel Lara
GL
Flores
Mónica
M
Morgues
Alfredo García-Alix
AG
Pérez
Bart
B
Van Overmeire
Frank
F
van Bel
D006801:Humans; D018496:Hyperoxia / Q000517:prevention & control*; D000860:Hypoxia / Q000517:prevention & control*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D015931:Intensive Care, Neonatal / Q000592:standards*; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood*; D016032:Randomized Controlled Trials as Topic
D010100:Oxygen
Hyperoxia; Oximetry; Oxygen saturation; Premature infant; Retinopathy of prematurity