Cascade reactions in nanoreactors.
In an attempt to mimic the biosynthetic efficiencies of nature and in a search for greener, more sustainable alternatives to nowadays ways of producing chemicals, one-pot cascade reactions have attracted a lot of attention in the past decade. Since most catalysts are not compatible with each other, compartmentalization techniques have often been applied to prevent catalyst inactivation. A various array of nanoreactors have been developed to meet the demand of having a site-isolated catalyst system, while maintaining the catalyst activity. Both multienzyme nanoreactors as well as enzyme/metal catalyst or organocatalyst systems have shown great potential in one-pot cascade reactions and hold promise for future developments in this field.
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
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MC
van Oers
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
F P J T
FP
Rutjes
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. Electronic address: j.vanhest@science.ru.nl.
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JC
van Hest
D001557:Benzenesulfonates / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D019149:Bioreactors; D002384:Catalysis; D004798:Enzymes / Q000378:metabolism; D008670:Metals / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry
D001557:Benzenesulfonates; D001672:Biocompatible Materials; D004798:Enzymes; D008670:Metals; D011108:Polymers; D011759:Pyrrolidines; C032519:pyrrolidine; C029501:4-toluenesulfonic acid