FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature.
Intravascular large B-cell lymphoma (IVLBCL) remains a diagnostic challenge, because of non-specific findings on clinical, laboratory, and imaging studies. We present a case in which 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography was particularly useful to suspect the diagnosis, to detect unexpected locations, to guide contributive biopsy, and to assess the response to treatment. In case of initial negative results, FDG-PET should be repeated in the course of clinical evolution. In the presence of neurological or hormonal symptoms without brain magnetic resonance imaging abnormality, FDG-PET brain slices could depict additional pituitary and/or brain hypermetabolisms. We discuss the potential interests of FDG-PET in IVLBCL by a literature review.
Department of Nuclear Medicine, CHU Timone, Marseille, France.
Cecile
C
Colavolpe
Department of Internal Medicine, CHU Conception, Marseille, France.
Mikael
M
Ebbo
Department of Thoracic Surgery, CHU Nord, Marseille, France.
Delphine
D
Trousse
Department of Internal Medicine, CHU Conception, Marseille, France.
Hajar
H
Khibri
Department of Neurology, CHU Timone, Marseille, France.
Jerome
J
Franques
Department of Bio-pathology, Institut Paoli-Calmettes, Marseille, France.
Bruno
B
Chetaille
Department of Onco-hematology, Institut Paoli-Calmettes, Marseille, France.
Diane
D
Coso
Department of Nuclear Medicine, Centre Antoine Lacassagne, Nice, France.
Matthieu John
MJ
Ouvrier
Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France.
Lauris
L
Gastaud
Department of Nuclear Medicine, CHU Timone, Marseille, France.
Eric
E
Guedj
Department of Internal Medicine, CHU Conception, Marseille, France.
Nicolas
N
Schleinitz
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D003371:Cough / Q000209:etiology; D018450:Disease Progression; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012074:Remission Induction; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
FDG-PET/CT; intravascular diffuse large B-cell lymphoma; lung biopsy