New Lycopodium alkaloids from Phlegmariurus squarrosus.
Four new Lycopodium alkaloids (1-4), together with 15 known ones, were isolated from club moss Phlegmariurus squarrosus. Notably, 8α-hydroxylycojapodine A (1) was the first derivative of lycojapodine A (5) which was a novel C16N-type Lycopodium alkaloid with an unprecedented 6/6/6/7 tetracyclic ring system. Their structures were elucidated based on the spectroscopic data, including 1D and 2D NMR techniques.
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
Fei
F
Liu
Liao-Bin
LB
Dong
Xiu
X
Gao
Xing-De
XD
Wu
Juan
J
He
Li-Yan
LY
Peng
Xiao
X
Cheng
Qin-Shi
QS
Zhao
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D029542:Lycopodiaceae / Q000737:chemistry*; D032502:Lycopodium / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C539671:lycojapodine A; D009569:Nitric Oxide
11β-acetoxyl-N-methylhuperzine B; 8α-hydroxylycojapodine A; 8β-acetoxy-12β-hydroxy-epidihydrolycopodine; 8β-acetyllycoposerramine-U; Lycopodium alkaloids; Phlegmariurus squarrosus