trans-10,cis-12 conjugated linoleic acid specifically increases tissue α-tocopherol mediated by PPARγ inhibition in mice.
C57BL/6J mice were divided into control group (C), CLA, c9t11, or t10c12 groups. CLA and t10c12 significantly increased α-tocopherol levels in the plasma and various tissues in experiment 1. The CLA and t10c12 groups also showed a significant increase in hepatic α-tocopherol transfer protein (α-TTP) levels. In experiment 2, mice were divided into control, CLA, R (rosiglitazone, a PPARγ agonist), or CLA+R groups. Vitamin E levels in the liver, epididymal fat pad, kidney, and plasma were increased by CLA, and this effect was reduced in the CLA+R group. t10,c12-CLA is the most active isomer in the CLA mixture in the regulation of tissue vitamin E status and α-TTP protein levels in mice. The increase in liver vitamin E status in CLA-fed mice is mainly due to the effect of PPARγ inhibition.
Department of Health and Nutrition and.
Ming-Shyong
MS
Wang
Chia-Ling
CL
Chang
Chien-I
CI
Lee
Huey-Mei
HM
Shaw
D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D044243:Linoleic Acids, Conjugated / Q000737:chemistry / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D047495:PPAR gamma / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism; D024502:alpha-Tocopherol / Q000378:metabolism*
D052242:Adiponectin; D002352:Carrier Proteins; D044243:Linoleic Acids, Conjugated; D047495:PPAR gamma; D045162:Thiazolidinediones; D014280:Triglycerides; C017763:alpha-tocopherol transfer protein; C496197:trans-10,cis-12-conjugated linoleic acid; D000077154:Rosiglitazone; D014810:Vitamin E; D024502:alpha-Tocopherol
conjugated linoleic acid; mice; rosiglitazone; triglyceride; α-tocopherol