The gut microbiome, probiotics, bile acids axis, and human health.
The human gut microbiome produces potent ligands to bile acid receptors, and probiotics could act as therapeutics of bile acid dysmetabolism. A recent study in Cell Reports demonstrates that probiotic VSL#3 affects bile acid deconjugation and excretion, as well as the gut-liver FXR-FGF15 axis.
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
Mitchell Lawrence
ML
Jones
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
Catherine
C
Tomaro-Duchesneau
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada. Electronic address: satya.prakash@mcgill.ca.
Satya
S
Prakash
D001647:Bile Acids and Salts / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D064307:Microbiota / Q000187:drug effects*; D008954:Models, Biological; D019936:Probiotics / Q000627:therapeutic use*
D001647:Bile Acids and Salts; D008024:Ligands