Dynamics of magnetic particles near a surface: model and experiments on field-induced disaggregation.
Magnetic particles are widely used in biological research and bioanalytical applications. As the corresponding tools are progressively being miniaturized and integrated, the understanding of particle dynamics and the control of particles down to the level of single particles become important. Here, we describe a numerical model to simulate the dynamic behavior of ensembles of magnetic particles, taking account of magnetic interparticle interactions, interactions with the liquid medium and solid surfaces, as well as thermal diffusive motion of the particles. The model is verified using experimental data of magnetic field-induced disaggregation of magnetic particle clusters near a physical surface, wherein the magnetic field properties, particle size, cluster size, and cluster geometry were varied. Furthermore, the model clarifies how the cluster configuration, cluster alignment, magnitude of the field gradient, and the field repetition rate play a role in the particle disaggregation process. The simulation model will be very useful for further in silico studies on magnetic particle dynamics in biotechnological tools.
Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands and Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands.
A
A
van Reenen
Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands and Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands.
Y
Y
Gao
Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands and Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands.
A M
AM
de Jong
Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
M A
MA
Hulsen
Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands and Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands.
J M J
JM
den Toonder
Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands and Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands and Philips Research, Eindhoven, The Netherlands.
M W J
MW
Prins
D003102:Colloids / Q000737:chemistry*; D003198:Computer Simulation; D004058:Diffusion; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D008956:Models, Chemical; D010316:Particle Size; D013499:Surface Properties
D003102:Colloids; D058185:Magnetite Nanoparticles