[Long-term effects of hydroxychloroquine on metabolism of serum lipids and left ventricular structure and function in patients of systemic lupus erythematosus].
OBJECTIVE
To observe the long-term effects of hydroxychloroquine treatment on blood lipids and left ventricular function of systemic lupus erythematosus (SLE) patients.


METHODS
A total of 72 SLE patients were randomly divided into 2 groups of hydroxychloroquine treatment (n = 36) and non-hydroxychloroquine (n = 36). The serum level of lipids, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), fractional shortening rate (FS), left ventricular ejection fraction (LVEF) and E/A ratio were measured before, 6 month, 12 month and 2 years after treatment.


RESULTS
After long-term use of hydroxychloroquine, there were statistically differences in the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). And LVEDD, LVWPT and E/A were statistically different (P < 0.05) before and after hydroxychloroquine dosing.


CONCLUSIONS
The long-term use of hydroxychloroquine may improve lipid metabolism and left ventricular function in SLE patients.
Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Juan
J
Meng
Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email: llyyww615@sina.com.
Yuewu
Y
Lu
Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Xin
X
Dong
Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Hongyan
H
Liu
D000328:Adult; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects
D008055:Lipids; D006886:Hydroxychloroquine