[A meta-analysis on the relations between Helicobacter pylori infection and chronic urticaria].
OBJECTIVE
To investigate the relationship between Helicobacter pylori (HP) infection and the development of chronic urticaria.


METHODS
Published case-control studies which concerned HP infection related chronic urticaria were searched in Wanfang, CNKI, CQVIP Chinese databanks and PubMed. Meta-analysis was applied to analyze the pooled odds ratio (OR) and 95% confidence interval (CI).


RESULTS
37 studies which comprised 2 909 cases of chronic urticaria and 1 873 persons served as controls were enrolled. When compared with the controls, HP infection significantly increased the risk of chronic urticaria development with a pooled OR of 3.20 (95% CI: 2.31-4.43). Results from Meta-regression analyses showed that the distribution of residential areas and detection method being used were potential influential factors.


CONCLUSIONS
HP infection seemed to be associated with an increased risk of developing the chronic urticaria.
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Lude
L
Tang
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Yanjun
Y
Zhang
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Xiaomeng
X
Gao
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Rui
R
Dong
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Xifeng
X
Zhang
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Hongxi
H
Gu
Department of Microbiology, Harbin Medical University, Harbin 150081, China. Email: shangqingl@163.com.
Qinglong
Q
Shang
D016022:Case-Control Studies; D002908:Chronic Disease; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D014581:Urticaria / Q000209:etiology*