Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA).
OBJECTIVE
To investigate the efficacy of erlotinib versus docetaxel in previously treated patients with advanced non-small-cell lung cancer (NSCLC) in an epidermal growth factor receptor (EGFR) -unselected patient population.


METHODS
The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), response rate, safety, and analyses on EGFR wild-type tumors. Patients with stage IIIB or IV NSCLC, previous treatment with one or two chemotherapy regimens, evaluable or measurable disease, and performance status of 0 to 2 were eligible.


RESULTS
From August 2009 to July 2012, 150 and 151 patients were randomly assigned to erlotinib (150 mg daily) and docetaxel (60 mg/m(2) every 3 weeks), respectively. EGFR wild-type NSCLC was present in 109 and 90 patients in the erlotinib and docetaxel groups, respectively. Median PFS for erlotinib versus docetaxel was 2.0 v 3.2 months (hazard ratio [HR], 1.22; 95% CI, 0.97 to 1.55; P = .09), and median OS was 14.8 v 12.2 months (HR, 0.91; 95% CI, 0.68 to 1.22; P = .53), respectively. In a subset analysis of EGFR wild-type tumors, PFS for erlotinib versus docetaxel was 1.3 v 2.9 months (HR, 1.45; 95% CI, 1.09 to 1.94; P = .01), and OS was 9.0 v 10.1 months (HR, 0.98; 95% CI, 0.69 to 1.39; P = .91), respectively.


CONCLUSIONS
Erlotinib failed to show an improvement in PFS or OS compared with docetaxel in an EGFR-unselected patient population.
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan. t-kawaguchi@kch.hosp.go.jp.
Tomoya
T
Kawaguchi
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Masahiko
M
Ando
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Kazuhiro
K
Asami
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Yoshio
Y
Okano
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Masaaki
M
Fukuda
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Hideyuki
H
Nakagawa
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Hidenori
H
Ibata
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Toshiyuki
T
Kozuki
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Takeo
T
Endo
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Atsuhisa
A
Tamura
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Mitsuhiro
M
Kamimura
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Kazuhiro
K
Sakamoto
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Michihiro
M
Yoshimi
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Yoshifumi
Y
Soejima
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Yoshio
Y
Tomizawa
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Shun-ichi
S
Isa
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Minoru
M
Takada
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Hideo
H
Saka
Tomoya Kawaguchi, Kazuhiro Asami, and Shun-ichi Isa, National Hospital Organization Kinki-Chuo Chest Medical Center; Minoru Takada, Koyo Hospital, Osaka; Masahiko Ando, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital; Akihito Kubo, Aichi Medical University School of Medicine, Aichi; Yoshio Okano, National Hospital Organization Kochi Hospital, Kochi; Masaaki Fukuda, National Hospital Organization Nagasaki Medical Center, Nagasaki; Hideyuki Nakagawa, National Hospital Organization Hirosaki Hospital, Hirosaki; Hidenori Ibata, National Hospital Organization Mie Chuo Medical Center, Tsu; Toshiyuki Kozuki, National Hospital Organization Shikoku Cancer Center, Matsuyama; Takeo Endo, National Hospital Organization Mito Medical Center, Mito; Atsuhisa Tamura, National Hospital Organization Tokyo Hospital; Mitsuhiro Kamimura, National Hospital Organization Disaster Medical Center, Tokyo; Kazuhiro Sakamoto, National Hospital Organization Yokohama Medical Center, Yokohama; Michihiro Yoshimi, National Hospital Organization Fukuoka East Medical Center, Fukuoka; Yoshifumi Soejima, National Hospital Organization Ureshino Medical Center, Ureshino; Yoshio Tomizawa, National Hospital Organization Nishigunma Hospital, Gunma; and Hideo Saka, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Akihito
A
Kubo
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D018572:Disease-Free Survival; D000077143:Docetaxel; D066246:ErbB Receptors / Q000235:genetics; D000069347:Erlotinib Hydrochloride; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011799:Quinazolines / Q000627:therapeutic use*; D043823:Taxoids / Q000627:therapeutic use*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D011799:Quinazolines; D043823:Taxoids; D000077143:Docetaxel; D000069347:Erlotinib Hydrochloride; C512478:EGFR protein, human; D066246:ErbB Receptors