[Premature ovarian failure].
This article is a review on different aspects of premature ovarian failure (POF) defined as the development of hypogonadism in women before 40 years of age. The review will discuss the etiopathogeny, autoimmune and iatrogenic causes, abnormalities of chromosome X, as well as clinical manifestations, diagnosis, and treatment. Most of the women with this disorder do not have menstrual history, specific of POF development, but infertility associated with the diagnosis is the most problematic aspect of the disease.
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Universidade do Estado do Rio de Janeiro.
Carmen Regina Leal de
CR
Assumpção
D000328:Adult; D002869:Chromosome Aberrations; D041321:Chromosomes, Human, X / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics; D006801:Humans; D007006:Hypogonadism / Q000209:etiology; D015994:Incidence; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D006080:Ovarian Follicle / Q000187:drug effects / Q000528:radiation effects; D010053:Ovary / Q000000981:diagnostic imaging; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D014463:Ultrasonography
D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human