Prevalence of Toxoplasma gondii and Toxocara canis among patients with uveitis.
OBJECTIVE
To investigate the prevalence of Toxoplasma gondii and Toxocara canis in patients with uveitis.


METHODS
Patients with uveitis were examined. Serum antibodies to T. gondii and T. canis were tested by using enzyme-linked immunosorbent assay (ELISA). Polymerase chain reaction (PCR) was done using blood and aqueous humor (AH).


RESULTS
98 patients were enrolled. Mean age was 43.5 ± 13.2 years. Six patients were seropositive for T. gondii with the following pattern-anterior uveitis: 1; posterior uveitis with retinitis: 2; pan uveitis: 2. One patient had a positive result of PCR for T.gondii in AH, who showed pan uveitis. 23 patients were positive to serum IgG for T. canis with the following clinical manifestation-granuloma: 6; pigmented scar: 3; virtrits: 6-but none were PCR positive.


CONCLUSIONS
T.gondii and T.canis are still one of the important causes of uveitis. Ocular toxocariasis is not an uncommon cause of uveitis even in adult.
The retina center of Nune Eye Hospital , Seoul , Korea .
Su Jin
SJ
Lim
Sang Eun
SE
Lee
Sun Hyun
SH
Kim
Sung-Hee
SH
Hong
Yong Sung
YS
You
Oh Woong
OW
Kwon
Hyeun Seung
HS
Kim
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D000913:Antibodies, Protozoan / Q000032:analysis; D001082:Aqueous Humor / Q000469:parasitology; D015153:Blotting, Western; D018509:DNA, Helminth / Q000032:analysis; D016054:DNA, Protozoan / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D015822:Eye Infections, Parasitic / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D017166:Toxocara canis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D014120:Toxocariasis; D014122:Toxoplasma / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology; D015866:Uveitis, Posterior / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology; D055815:Young Adult
D000909:Antibodies, Helminth; D000913:Antibodies, Protozoan; D018509:DNA, Helminth; D016054:DNA, Protozoan
Ocular toxocariasis; ocular toxoplasmosis; parasite; serologic test; uveitis