Five-year longitudinal assessment (2008 to 2012) of E-101 solution activity against clinical target and antimicrobial-resistant pathogens.
This study summarizes the topical E-101 solution susceptibility testing results for 760 Gram-positive and Gram-negative target pathogens collected from 75 U.S. sites between 2008 and 2012 and 103 ESKAPE pathogens. E-101 solution maintained potent activity against all bacterial species studied for each year tested, with MICs ranging from <0.008 to 0.25 μg porcine myeloperoxidase (pMPO)/ml. These results confirm that E-101 solution retains its potent broad-spectrum activity against U.S. clinical isolates and organisms with challenging resistance phenotypes.
Indiana University School of Medicine, Indianapolis, Indiana, USA gdenys@iupui.edu.
Gerald A
GA
Denys
Eurofins Medinet, Chantilly, Virginia, USA.
Chris M
CM
Pillar
Eurofins Medinet, Chantilly, Virginia, USA.
Daniel F
DF
Sahm
Exoxemis, Inc., Little Rock, Arkansas, USA.
Peter
P
O'Hanley
Exoxemis, Inc., Little Rock, Arkansas, USA.
Jackson T
JT
Stephens
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D005949:Glucose Oxidase / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000517:prevention & control*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000517:prevention & control*; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D006997:Hypochlorous Acid / Q000737:chemistry; D008137:Longitudinal Studies; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000737:chemistry; D019999:Pharmaceutical Solutions / Q000737:chemistry / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry
D000890:Anti-Infective Agents; D019999:Pharmaceutical Solutions; D026082:Singlet Oxygen; D006997:Hypochlorous Acid; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase; D009195:Peroxidase