Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.
OBJECTIVE
To investigate whether chimerin 2 (CHN2) genetic polymorphisms were associated with the susceptibility to diabetic retinopathy (DR) in Taiwanese individuals with type 2 diabetes.


METHODS
This case-control study comprised of 171 individuals with DR and 548 without DR. Four rs39059, rs2023908, rs1002630 and rs1362363 polymorphism of CHN2 were genotyped for each subjects. All subjects underwent a complete ophthalmologic examination, and basic information (age, gender, age at diagnosis of diabetes, and ocular history of the patient) was record. Several clinical parameters (systolic and diastolic blood pressure, waist and hip circumferences, body mass index levels, fasting glucose and HbA1c) were measured.


RESULTS
Logistic regressions were used to analyze odds ratios between SNPs and DR after controlling for gender, systolic blood pressure, waist and hip ratio, duration of diabetes, serum HbA1c levels and nephropathy classification. A protective effect of rs1002630 (GA+AA) and rs1362363 (AG+GG) [odds ratio (OR) (95% confidence interval)=0.45 (0.22-0.88), 0.66 (0.44-0.99), respectively) was observed. Furthermore, the protective effect of rs1002630 was observed when compared subjects with non-proliferative DR with subjects without DR [OR=0.25 (95%C.I. = 0.09-0.73)].


CONCLUSIONS
This study showed that the rs1002630 of CHN2 were associated with DR risk and non-proliferative DR risk in Taiwanese individuals with type 2 diabetes. Variations at this locus may contribute to the pathogenesis of DR.
Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; School of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Marcelo
M
Chen
Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan.
Wun-Rong
WR
Lin
Division of Endocrinology and Metabolism of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Chieh-Hsiang
CH
Lu
Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Ching-Chu
CC
Chen
School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Yu-Chuen
YC
Huang
Center for Personalized Medicine, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrate Medicine, School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address: T12678@mail.cmuh.org.tw.
Wen-Ling
WL
Liao
School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address: d0704@www.cmuh.org.tw.
Fuu-Jen
FJ
Tsai
D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D020740:Chimerin Proteins / Q000235:genetics* / Q000378:metabolism; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012160:Retina / Q000473:pathology; D012720:Severity of Illness Index; D013624:Taiwan
D020740:Chimerin Proteins; C000593185:chimaerin-beta3 protein, human
CHN2; Diabetic retinopathy; Single nucleotide polymorphism; Taiwanese; Type 2 diabetes