Factitious hypobicarbonatemia associated with profound hyperlipidemia.
We describe a patient who presented on two occasions with severe hypobicarbonatemia and an associated high anion gap on enzymatic analysis. She also had profound hyperlipidemia. Her low bicarbonate was shown to be factitious by analysis of her blood using a direct ion-selective electrode method. Reanalysis of blood samples after treatment with a lipid clearing agent resulted in marked improvement in the bicarbonate level. We suggest that the light scattering effect of the hyperlipidemia interfered with the photometric analysis causing this factitious phenomenon.
Division of Nephrology and Hypertension, University of South Florida Morsani College of Medicine , Tampa, FL , USA and.
Stephen I
SI
Rifkin
Beth
B
Shaub
D000136:Acid-Base Equilibrium; D000328:Adult; D016477:Artifacts; D001639:Bicarbonates / Q000097:blood*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*
D001639:Bicarbonates
Acidosis; anion gap; artifact; bicarbonate; hyperlipidemia