Opioid requirements in mechanically ventilated trauma patients receiving dexmedetomidine versus propofol.
Proponents of dexmedetomidine often cite the agent's analgesic properties as one of its main advantages over propofol and benzodiazepines. However, there are very limited studies utilizing endpoints such as analgesic requirements to provide supporting evidence for these claims. The primary purpose of this retrospective study was to compare opioid analgesic requirements in trauma patients receiving nonconcurrent dexmedetomidine and propofol for sedation while being weaned from mechanical ventilation. Total analgesic requirements were similar between dexmedetomidine and propofol within 48 hours of sedative initiation in adult trauma patients (P > .05).
Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson (Drs Aljuhani, McKinney, and Erstad); University of Arizona Medical Center, University Campus, Tucson (Drs Aljuhani and McKinney); Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia (Dr Aljuhani); and Intermountain Medical Center, Murray, Utah (Dr McKinney).
Ohoud A
OA
Aljuhani
Courtney B
CB
McKinney
Brian L
BL
Erstad
D018806:APACHE; D000328:Adult; D015331:Cohort Studies; D016292:Procedural Sedation / Q000009:adverse effects / Q000379:methods; D003422:Critical Care / Q000379:methods; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D012121:Respiration, Artificial / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment; D014193:Trauma Centers; D015599:Trauma Severity Indices; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000379:methods*; D014947:Wounds and Injuries / Q000175:diagnosis / Q000628:therapy*
D020927:Dexmedetomidine; D015742:Propofol