Newly diagnosed type 1 diabetes complicated by ketoacidosis and peripheral thrombosis leading to transfemoral amputation.
Peripheral vascular thromboembolism is a rarely described complication of diabetic ketoacidosis. We report a 41-year-old otherwise healthy man admitted with ketoacidosis and ischaemia of the left foot. The patient was unsuccessfully treated with thromboendarterectomy, and the extremity was ultimately amputated. The patient had no family history of cardiovascular disease, and all blood sample analyses for hypercoagulability were negative. We recommend an increased focus on peripheral thromboembolism, when treating patients with severe ketoacidosis.
Department of Medical Endocrinology, Odense University Hospital (OUH), Odense C, Denmark.
Line Bisgaard
LB
Jørgensen
Department of Orthopaedic Surgery, Odense University Hospital (OUH), Odense C, Denmark.
Ole
O
Skov
Department of Medical Endocrinology, Odense University Hospital (OUH), Odense C, Denmark.
Knud
K
Yderstræde
D000328:Adult; D000671:Amputation, Surgical / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D016883:Diabetic Ketoacidosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D018450:Disease Progression; D005269:Femur / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D012086:Reoperation / Q000379:methods; D018570:Risk Assessment; D017131:Thrombectomy / Q000379:methods; D013923:Thromboembolism / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome