Room-temperature ligand-free Pd/C-catalyzed C-S bond formation: synthesis of 2-substituted benzothiazoles.
The synthesis of 2-substituted benzothiazoles has been achieved via cyclization of o-iodothiobenzanilide derivatives using Pd/C as the catalyst at room temperature. The protocol is ligand-free, additive-free, and high-yielding and involves very mild conditions.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering, and Materials Science, Soochow University , 199 RenAi Road, Suzhou, Jiangsu 215123, China.
Yannan
Y
Cheng
Qian
Q
Peng
Weigang
W
Fan
Pixu
P
Li