Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs.
Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.
Department of Infection Biology, Institute of Infection and Global Health, School of Veterinary Science, University of Liverpool, Liverpool, L3 5RF, UK; CIGMR (Centre for Integrated Genomic Medical Research), Faculty of Medical and Human Sciences Manchester University, Manchester, M13 9PT, UK.
A E G
AE
Baird
S D
SD
Carter
J F
JF
Innes
W
W
Ollier
A
A
Short
D000818:Animals; D000070598:Anterior Cruciate Ligament Injuries; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs / Q000293:injuries*; D055106:Genome-Wide Association Study / Q000662:veterinary*; D020641:Polymorphism, Single Nucleotide; D013045:Species Specificity
Newfoundlands; cranial cruciate ligament rupture; population stratification