Relationship between the prefrontal function and the severity of the emotional symptoms during a verbal fluency task in patients with major depressive disorder: a multi-channel NIRS study.
Multi-channel near-infrared spectroscopy (NIRS) is a noninvasive and low-cost functional neuroimaging technique in psychiatric research, and it has been wildly used for detecting the spatiotemporal characteristics of brain activity. In order to evaluate the clinical value of NIRS data in the assistant diagnosis of major depressive disorder (MDD), prefrontal cortex (PFC) hemoglobin concentration exchange of 30 MDD patients combined with anxious and obsessive-compulsive symptom was detected by NIRS under voice fluency task (VFT), then the relationship between the severity of depressive, anxious and obsessive-compulsive symptom assessed by Hamilton Rating Scale for Depression (HAMD), Hamilton Anxiety Rating Scale (HAMA) and Yale-Brown Obsessive Compulsive Scale (Y-BOCS) with NIRS data in PFC was analyzed. Hypoactivation in lateral and lower PFC of MDD patients was confirmed in this study. Furthermore, Spearman correlation found that oxy-hemoglobin concentration ([oxy-Hb]) exchange in right-lateral PFC was associated with the severity of anxiety, while bilateral PFC and antero-medial PFC were associated with severity of depression. Meanwhile, no statistical correlation was observed on the severity of obsessive-compulsive symptom. The results prompted that MDD patients with anxiety and obsession-compulsion symptom showed a PFC hypoactivation state in NIRS. Furthermore, the function of right-lateral PFC was associated with anxiety symptom, while bilateral PFC and antero-medial PFC were associated with depression symptom. Different from depression and anxiety, obsession-compulsion may have a different biological character in PFC function.
Medical Center, Tsinghua Unversity, Beijing, China; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Xiaomin
X
Liu
Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Gaoxiang
G
Sun
Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Xiaoqian
X
Zhang
Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Bo
B
Xu
Medical Center, Tsinghua Unversity, Beijing, China; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Chenyu
C
Shen
Medical Center, Tsinghua Unversity, Beijing, China; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Lujie
L
Shi
Medical Center, Tsinghua Unversity, Beijing, China; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Xiangyun
X
Ma
Medical Center, Tsinghua Unversity, Beijing, China; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Xiajin
X
Ren
Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China.
Kun
K
Feng
Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China. Electronic address: liupozi@tsinghua.edu.cn.
Pozi
P
Liu
D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000175:diagnosis / Q000503:physiopathology; D003192:Compulsive Behavior / Q000175:diagnosis / Q000503:physiopathology; D003863:Depression / Q000175:diagnosis / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009770:Obsessive Behavior / Q000175:diagnosis / Q000503:physiopathology; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014705:Verbal Behavior / Q000502:physiology*; D055815:Young Adult
D010108:Oxyhemoglobins
Anxious symptom; Major depressive disorder; Near-infrared spectroscopy (NIRS); Neurocognition; Obsessive–compulsive symptom; Prefrontal cortex