Adiponectin gene variants, adiponectin isoforms and cardiometabolic risk in type 2 diabetic patients.
OBJECTIVE
The aim of the present study was to examine the associations of rs2241766 (+45T>G), rs1501299 (+276G>T), rs17300539 (-11391G>A) and rs182052 (-10069G>A) in the adiponectin (Ad) gene with adiponectin concentrations, and concomitantly the association of these variants with cardiometabolic risk in type 2 diabetic patients of African ancestry.


METHODS
A cross-sectional study of 200 patients was carried out. Concentrations of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms were measured. The four polymorphisms were genotyped.


RESULTS
Decreased values were noted for total Ad in overweight, dyslipidemia and coronary artery disease (CAD), for HMW in overweight and dyslipidemia, for MMW in CAD, for LMW in dyslipidemia and CAD, for the percentage HMW/total in overweight, and for MMW:HMW ratio in patients without hypertriglyceridemic waist (HTGW). Significant associations were noted between total Ad, HMW, and HMW/total Ad and rs182052 under a dominant model (P = 0.04, P = 0.03 and P = 0.04, respectively), and between MMW and rs17300539 (P = 0.006). No significant difference in adiponectin concentrations was noted according to rs2241766 and rs1501299 genotypes. Patients carrying the rs2241766 G allele (TG+GG) had an increased risk of HTGW (odds ratio [OR] 3.1; P = 0.04) and of CAD (OR 3.3; P = 0.01). The odds of having low total adiponectin concentrations (<25th percentile: 3.49 ng/mL) for carrying the rs182052A allele (AA+GA) was: OR 0.40; P = 0.009. The single-nucleotide polymorphism associated with adiponectin levels was not concomitantly associated with cardiometabolic risk factors.


CONCLUSIONS
Adiponectin concentrations and ADIPOQ variants are implicated in the pathophysiological process leading to cardiovascular diseases, but the genetic effects seem to be independent of adiponectin concentrations in our Afro-Caribbean diabetic patients.
Research Group Clinical Epidemiology and Medicine ECM/L.A.M.I.A EA 4540 University Hospital of Guadeloupe University of Antilles and Guyane Guadeloupe France ; Department of Medical Information and Public Health University Hospital of Pointe-à-Pitre Guadeloupe France.
Lydia
L
Foucan
INSERM U695 Genetic determinants of type 2 diabetes and its vascular complications Paris France ; University Paris Diderot Sorbonne Paris Cité UMRS 695 UFR de Médecine Site Bichat Paris France.
Suliya
S
Maimaitiming
Research Group Clinical Epidemiology and Medicine ECM/L.A.M.I.A EA 4540 University Hospital of Guadeloupe University of Antilles and Guyane Guadeloupe France ; Cardiology Unit University Hospital of Pointe-à-Pitre Guadeloupe France.
Laurent
L
Larifla
Cardiology Unit University Hospital of Pointe-à-Pitre Guadeloupe France.
Segho
S
Hedreville
Research Group Clinical Epidemiology and Medicine ECM/L.A.M.I.A EA 4540 University Hospital of Guadeloupe University of Antilles and Guyane Guadeloupe France ; Department of Medical Information and Public Health University Hospital of Pointe-à-Pitre Guadeloupe France.
Jacqueline
J
Deloumeaux
Research Group Clinical Epidemiology and Medicine ECM/L.A.M.I.A EA 4540 University Hospital of Guadeloupe University of Antilles and Guyane Guadeloupe France.
Marie-Odile
MO
Joannes
Research Group Clinical Epidemiology and Medicine ECM/L.A.M.I.A EA 4540 University Hospital of Guadeloupe University of Antilles and Guyane Guadeloupe France.
Anne
A
Blanchet-Deverly
Research Group Clinical Epidemiology and Medicine ECM/L.A.M.I.A EA 4540 University Hospital of Guadeloupe University of Antilles and Guyane Guadeloupe France.
Fritz-Line
FL
Velayoudom-Céphise
INSERM U695 Genetic determinants of type 2 diabetes and its vascular complications Paris France.
Roberte
R
Aubert
Inserm U897 Bordeaux School of Public Health Victor Segalen Bordeaux 2 University Bordeaux France.
Roger
R
Salamon
Diabetology Unit University Hospital of Pointe-à-Pitre Guadeloupe France.
Jean-Paul
JP
Donnet
INSERM U695 Genetic determinants of type 2 diabetes and its vascular complications Paris France ; University Paris Diderot Sorbonne Paris Cité UMRS 695 UFR de Médecine Site Bichat Paris France.
Frederic
F
Fumeron
Adiponectin; Cardiometabolic risk; Diabetes