Regulating the regulator of ROS production.
Balancing inflammatory reactive oxygen species (ROS) production is essential for safely eliminating pathogenic microbes. The newly described protein Negative Regulator of ROS (NRROS) dampens ROS production by restricting NOX2 availability, and thus "cools-off" inflammation.
1] Department of Pharmacology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [2] Department of Medicine, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [3] Department of Pathology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA.
Marcelo G
MG
Bonini
1] Department of Pharmacology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [2] Center for Lung and Vascular Biology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA.
Asrar B
AB
Malik
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism*; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D008089:Listeria monocytogenes / Q000276:immunology*; D008297:Male; D011506:Proteins / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors*
D011506:Proteins; D017382:Reactive Oxygen Species