First-trimester 3D power Doppler of the uteroplacental circulation space and fetal growth restriction.
OBJECTIVE
The objective of the study was to compare the 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space in the first trimester between women who subsequently deliver growth-restricted vs normally grown neonates.


METHODS
This was a prospective observational study of singleton pregnancies at 11-14 weeks' gestation. The 3DPD indices, vascularization index, flow index, and vascularization flow index were determined on a uteroplacental circulation space sphere biopsy with the virtual organ computer-aided analysis program. Growth restriction was defined as a birthweight less than the 10th percentile for gestational age and was evaluated using both population-based and customized birth curves.


RESULTS
Five hundred seventy-seven women were enrolled. Five hundred twenty-six were eligible for analysis using population centiles, and 497 were available for evaluation using customized centiles. There was no difference in the first-trimester 3DPD indices between patients with growth-restricted and normally grown neonates using either curve.


CONCLUSIONS
Three-dimensional power Doppler indices of the uteroplacental circulation space in the first trimester are similar between neonates who develop growth restriction and those who will grow normally.
Division of Fetal Medicine and Obstetrics and Gynecology Ultrasound, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY. Electronic address: marar01@gmail.com.
Mara
M
Rosner
Division of Fetal Medicine and Obstetrics and Gynecology Ultrasound, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Pe'er
P
Dar
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Laura L
LL
Reimers
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Thomas
T
McAndrew
Division of Fetal Medicine and Obstetrics and Gynecology Ultrasound, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Juliana
J
Gebb
D000293:Adolescent; D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008297:Male; D010920:Placenta / Q000000981:diagnostic imaging*; D021041:Placental Circulation; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D016216:Ultrasonography, Prenatal / Q000379:methods*; D014599:Uterus / Q000000981:diagnostic imaging*; D055815:Young Adult
Doppler; fetal growth restriction; placenta