Anticancer activity of new depsipeptide compound isolated from an endophytic fungus.
A novel depsipeptide (PM181110) was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata (family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close in structure to FE399. The compound exhibited in vitro anticancer activity against 40 human cancer cell lines with a mean IC50 value of 0.089 μM and ex vivo efficacy towards 24 human tumor xenografts (mean IC50=0.245 μM).
Piramal Enterprises Limited, Mumbai, India.
Shilpa Amit
SA
Verekar
Piramal Enterprises Limited, Mumbai, India.
Prabhu Dutt
PD
Mishra
Piramal Enterprises Limited, Mumbai, India.
Eyyammadichiyil Sankaranarayanan
ES
Sreekumar
Piramal Enterprises Limited, Mumbai, India.
Sunil Kumar
SK
Deshmukh
Oncotest GmbH, Institut für experimentelle Onkologie, Freiburg, Germany.
Heinz-Herbert
HH
Fiebig
Oncotest GmbH, Institut für experimentelle Onkologie, Freiburg, Germany.
Gerhard
G
Kelter
Oncotest GmbH, Institut für experimentelle Onkologie, Freiburg, Germany.
Armin
A
Maier
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000302:isolation & purification; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D060026:Endophytes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D033641:Millettia / Q000382:microbiology; D015394:Molecular Structure; D018515:Plant Leaves / Q000382:microbiology; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D001688:Biological Products; D047630:Depsipeptides