Self-assembled cardanol azo derivatives as antifungal agent with chitin-binding ability.
Cardanol is a non-isoprenoic phenolic lipid-mixture of distilled cashew nut shell liquid obtained from Anacardium occidentale. Herein, cardanol is purified from cashew nut shell liquid (CNSL) and synthesized to new compounds with different azo amphiphiles. These synthesized compounds are allowed to self-assembled in hydrophobic environment and checked antifungal activity against Candida albicans. Self-assembled structure of CABA showed higher antifungal activity (16μg/mL) and chitin-binding ability in comparison to CAP and CANB. Furthermore, the self-assembled azo amphiphiles are immobilized with silver ions to prepare hydrogel which showed eight folds enhanced antifungal activity. Toxicity is reduced by several folds of self-assembled or hydrogel structure in comparison to pure compounds. Thus, the self-assembled structure of amphiphiles and their hydrogels have been found to be new macromolecules of interest with potential use as antifungal drugs.
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India. Electronic address: denial.mahata@gmail.com.
Denial
D
Mahata
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
Santi M
SM
Mandal
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
Rashmi
R
Bharti
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
Vinay Krishna
VK
Gupta
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
Mahitosh
M
Mandal
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
Ahindra
A
Nag
Rubber Technology Centre, Central Research Facility, Department of Chemistry, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India. Electronic address: golokb@rtc.iitkgp.ernet.in.
Golok B
GB
Nando
D031021:Anacardium / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D001391:Azo Compounds / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002686:Chitin / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D012834:Silver / Q000737:chemistry
D000935:Antifungal Agents; D001391:Azo Compounds; D020100:Hydrogels; D010636:Phenols; D002686:Chitin; D012834:Silver; C038590:cardanol
Antifungal hydrogel; Cardanol; Chitin-binding assay; Self-assembly