Self-assembled two-dimensional protein arrays in bionanotechnology: from S-layers to designed lattices.
Although the crystalline S-layer arrays that form the exoskeleton of many archaea and bacteria have been studied for decades, a long-awaited crystal structure coupled with a growing understanding of the S-layer assembly process are injecting new excitement in the field. The trend is amplified by computational strategies that allow for in silico design of protein building blocks capable of self-assembling into 2D lattices and other prescribed quaternary structures. We review these and other recent developments toward achieving unparalleled control over the geometry, chemistry and function of protein-based 2D objects from the nanoscale to the mesoscale.
Department of Chemical Engineering, University of Washington, Box 351750, Seattle, WA 98195-1750, USA. Electronic address: baneyx@uw.edu.
François
F
Baneyx
Department of Chemical Engineering, University of Washington, Box 351750, Seattle, WA 98195-1750, USA.
James F
JF
Matthaei
D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001411:Geobacillus stearothermophilus / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D040081:Protein Array Analysis / Q000295:instrumentation* / Q000639:trends; D015202:Protein Engineering; D020836:Protein Structure, Quaternary
D001426:Bacterial Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C055764:S-layer proteins; C104635:SbsB protein, Bacillus stearothermophilus