New cyclic cystine bridged peptides from the sponge Suberites waedoensis.
Two new peptides, chujamides A (1) and B (2), were isolated from the marine sponge Suberites waedoensis, which was collected from Korean waters. Based upon the results of the combined spectroscopic analyses, the structures of these compounds were determined to be proline-riched and cyclic cystine bridged dodeca- and undecapeptides. The absolute configurations of all amino acid residues were determined to be l by advanced Marfey's analysis. The new compounds exhibited weak cytotoxicities against A549 and K562 cell-lines, and compound 2 also demonstrated moderate inhibitory activity against Na⁺/K⁺-ATPase.
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. syoranzz@naver.com.
Jinhaeng
J
Song
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. mirabn@snu.ac.kr.
Ju-Eun
JE
Jeon
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. wth123@snu.ac.kr.
Tae Hyung
TH
Won
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea. cjsim@hnu.kr.
Chung J
CJ
Sim
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
Dong-Chan
DC
Oh
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. ohkibong@snu.ac.kr.
Ki-Bong
KB
Oh
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.
Jongheon
J
Shin
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D003545:Cysteine / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D056910:Republic of Korea; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D000596:Amino Acids; D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; C000593622:chujamide A; C000593623:chujamide B; D011392:Proline; D000254:Sodium-Potassium-Exchanging ATPase; D003545:Cysteine