Recurrent orbital adult-type fibrosarcoma in a 3-year-old girl.
A 3-year-old Filipino girl presented with progressive left-sided ptosis and proptosis after resection of a superomedial orbital tumor 2.5 years ago. She had been followed with serial MRI, which demonstrated interval growth of a recurrent lesion. Repeat resection was undertaken via an eyelid-splitting anterior orbitotomy. The patient's pediatric oncologist and sarcoma specialist did not recommend adjuvant chemotherapy, and the family declined proton radiotherapy. The patient will continue to be monitored with serial imaging. Histopathology, immunohistochemistry, and reverse transcriptase polymerase chain reaction were most consistent with a diagnosis of adult-type fibrosarcoma. This is the first reported case of adult-type fibrosarcoma presenting in the orbit of a child. Fibrosarcoma is a fibroblast-derived tumor that commonly presents in the extremities, usually in patients in their fourth to sixth decades. It is rarely seen in the orbit, with the largest case series to date only including 5 patients.
*Bascom Palmer Eye Institute, University of Miami Miller School of Medicine; †Florida Lions Eye Bank; and ‡Department of Pathology, University of Miami Hospital, Miami, Florida, U.S.A.
Rehan M
RM
Hussain
Benjamin P
BP
Erickson
Andrew E
AE
Rosenberg
Sander R
SR
Dubovy
Thomas E
TE
Johnson
D002675:Child, Preschool; D005094:Exophthalmos / Q000175:diagnosis; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local; D013508:Ophthalmologic Surgical Procedures; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000601:surgery; D020133:Reverse Transcriptase Polymerase Chain Reaction