Error correction and fast detectors implemented by ultrafast neuronal plasticity.
We experimentally show that the neuron functions as a precise time integrator, where the accumulated changes in neuronal response latencies, under complex and random stimulation patterns, are solely a function of a global quantity, the average time lag between stimulations. In contrast, momentary leaps in the neuronal response latency follow trends of consecutive stimulations, indicating ultrafast neuronal plasticity. On a circuit level, this ultrafast neuronal plasticity phenomenon implements error-correction mechanisms and fast detectors for misplaced stimulations. Additionally, at moderate (high) stimulation rates this phenomenon destabilizes (stabilizes) a periodic neuronal activity disrupted by misplaced stimulations.
Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Roni
R
Vardi
Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Hagar
H
Marmari
Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel and Department of Physics, Bar-Ilan University, Ramat-Gan 52900, Israel.
Ido
I
Kanter
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*