Association of adiponectin polymorphisms with the risk of diabetic nephropathy in type 2 diabetes: a meta-analysis.
OBJECTIVE
Adiponectin gene polymorphisms have been reported to be associated with the risk of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. However, the results are inconsistent.


METHODS
Electronic literature databases and reference lists of relevant articles published until December 2013 were searched as part of a systematic review and meta-analysis to clarify the association between adiponectin gene polymorphisms and DN susceptibility in T2DM. Fixed- or random-effects models were used to calculate the effect sizes of odds ratio (OR) and 95% confidence intervals (95% CI).


RESULTS
Eleven case control studies were included. Overall, a significant association was observed for rs2241766T/G polymorphisms under the recessive model (GG vs. TT+TG: OR 1.75; 95% CI 1.09-2.80; P = 0.02). For rs17300539G/A, a significant association was observed under the GA vs. GG model (OR 1.74; 95% CI 1.13-2.68; P = 0.01) and A vs. G allele model OR 1.65; 95% CI 1.13-2.41; P = 0.009). After stratification by ethnicity, we found that the rs2241766 T/G dominant model (GG+TG vs. TT: OR 1.52; 95% CI 1.12-2.07; P = 0.007), heterozygous model (TG vs. TT: OR 1.52; 95% CI 1.01-2.27; P = 0.04) and G vs. T allele (OR 1.50; 95% CI 1.07-2.10; P = 0.02) may be associated with DN risk in the Caucasian population. For rs17300593G/A, the dominant model (GA+AA vs. GG: OR 1.75; 95% CI 1.15-2.67; P = 0.009) may be associated with DN risk in the Caucasian population.


CONCLUSIONS
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuli
Y
Cai
Tianshu
T
Zeng
Lulu
L
Chen
D052242:Adiponectin / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D052242:Adiponectin
adiponectin; diabetic nephropathy; meta-analysis; polymorphisms; 关键词：脂联素，糖尿病肾病，meta分析，多态性