Gene regulation: the HSP70 gene jumps when shocked.
Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.
Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Maria
M
Vera
Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: robert.singer@einstein.yu.edu.
Robert H
RH
Singer
D000818:Animals; D018869:Heat-Shock Response; D006801:Humans; D015533:Transcriptional Activation; D019076:Transgenes