Dysfunction of Th1 and th2 lymphocytes and change in blood cytokine concentration at various stages of chronic intoxication with organophosphorus compounds.
Experiments on noninbred albino rats showed that a chronic exposure to organophosphorus compounds (carbophos and metaphos, 30 days, total dose 0.3 LD50) is primarily followed by a decrease in the immune reactions and IFN-γ associated with Th1 lymphocyte function (in comparison with the immune response due to activation of Th2 cells by IL-4). The concentrations of IL-2, IL-6, and IL-10 in the blood decreased after 30-day intoxication. The immune reactions associated with functional activity of Th1 and Th2 lymphocytes were shown to decrease similarly after chronic treatment with organophosphorus compounds for 60 days (total dose 0.6 LD50). This exposure was accompanied by a decrease in the concentrations of IFN-γ, IL-4, IL-2, and IL-6, but had no effect on the level of IL-10 in the blood.
Saratov Branch of the "REAVIZ" Samara Medical Institute, Saratov, Russia, pfzabrodsky@gmail.com.
P F
PF
Zabrodskii
M S
MS
Gromov
I Kh
IKh
Yafarova
D000818:Animals; D016207:Cytokines / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood; D007928:Lethal Dose 50; D008294:Malathion; D008743:Methyl Parathion; D009943:Organophosphorus Compounds / Q000276:immunology / Q000633:toxicity*; D051381:Rats; D018417:Th1 Cells / Q000187:drug effects* / Q000473:pathology; D018418:Th2 Cells / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D016207:Cytokines; D009943:Organophosphorus Compounds; D008743:Methyl Parathion; D007371:Interferon-gamma; D008294:Malathion