Midazolam premedication in attenuating ketamine psychic sequelae.
The objective of the study was to evaluate the effectiveness of midazolam premedication in attenuating the psychic sequelae of ketamine dissociative anaesthesia. Sixty patients undergoing various short surgical and urological procedures were taken in the study. All patients were premedicated with midazolam (0.05mg/kg i.v) five minutes before ketamine induction (1mg/kg i.v). The excitatory phenomenon, emergence delirium, occurrence of unpleasant dreams and patient acceptability of ketamine anaesthesia were recorded. Out of 60 patients studied, 15% had excitatory effects, 8% had mild delirium and 3% patients had unpleasant dreams in post operative period. Patient acceptability of ketamine anaesthesia was 100%. Hence from the study it was concluded that, midazolam premedication is effective in attenuating ketamine psychic sequelae.
Department of Pharmacology, S.V.S Medical College, Mahabubnagar 509002, Andhrapradesh, India.
S C
SC
Somashekara
Department of Pharmacology, S.V.S Medical College, Mahabubnagar 509002, Andhrapradesh, India.
D
D
Govindadas
Department of Pharmacology, S.V.S Medical College, Mahabubnagar 509002, Andhrapradesh, India.
G
G
Devashankaraiah
Department of Pharmacology, S.V.S Medical College, Mahabubnagar 509002, Andhrapradesh, India.
Rajkishore
R
Mahato
Department of Anatomy, S.V.S Medical College, Mahabubnagar 509002, Andhrapradesh, India.
S
S
Deepalaxmi
Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Bellary 583104, Karnataka, India.
V
V
Srinivas
Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Bellary 583104, Karnataka, India.
J V
JV
Murugesh
Department of Anaesthesiology, Vijayanagara Institute of Medical Sciences, Bellary 583104, Karnataka, India.
Devanand
Dissociative anaesthesia; Ketamine; Midazolam; Preaneasthetic medication