Impact of obesity on the predictive accuracy of prostate-specific antigen density and prostate-specific antigen in native Korean men undergoing prostate biopsy.
OBJECTIVE
To evaluate the impact of obesity on the biopsy detection of prostate cancer.


METHODS
We retrospectively reviewed data of 1182 consecutive Korean patients (≥50 years) with serum prostate-specific antigen levels of 3-10 ng/mL who underwent initial extended 12-cores biopsy from September 2009 to March 2013. Patients who took medications that were likely to influence the prostate-specific antigen level were excluded. Receiver operating characteristic curves were plotted for prostate-specific antigen and prostate-specific antigen density predicting cancer status among non-obese and obese men.


RESULTS
A total of 1062 patients (mean age 67.1 years) were enrolled in the analysis. A total of 230 men (21.7%) had a positive biopsy. In the overall study sample, the area under the receiver operator characteristic curve of serum prostate-specific antigen for predicting prostate cancer on biopsy were 0.584 and 0.633 for non-obese and obese men, respectively (P = 0.234). However, the area under the curve for prostate-specific antigen density in predicting cancer status showed a significant difference (non-obese 0.696, obese 0.784; P = 0.017).


CONCLUSIONS
There seems to be a significant difference in the ability of prostate-specific antigen density to predict biopsy results between non-obese and obese men. Obesity positively influenced the overall ability of prostate-specific antigen density to predict prostate cancer.
Department of Urology, College of Medicine, Soonchunhyang University, Cheonan, South Korea.
Jae Heon
JH
Kim
Seung Whan
SW
Doo
Won Jae
WJ
Yang
Kwang Woo
KW
Lee
Chang Ho
CH
Lee
Yun Seob
YS
Song
Yoon Su
YS
Jeon
Min Eui
ME
Kim
Soon-Sun
SS
Kwon
D000368:Aged; D019540:Area Under Curve; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009765:Obesity / Q000097:blood* / Q000150:complications; D009929:Organ Size; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology*; D012372:ROC Curve; D056910:Republic of Korea; D012189:Retrospective Studies
D017430:Prostate-Specific Antigen
obesity; prostatic specific antigen; prostatic specific antigen density; receiver operating characteristic curve