Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung.
We herein present a rare case of ALK-positive pulmonary pleomorphic carcinoma in an octogenarian patient. A computed tomography scan of the thorax indicated a pulmonary nodule in the right upper lobe of an asymptomatic 87-year-old female. The surgical resection revealed that the disease was pleomorphic carcinoma with pathological T2aN0M0, stage IB. EML4-ALK was evaluated using immunohistochemistry and fluorescence in situ hybridization, and EGFR mutations were analyzed using the Cycleave method. While there were no EGFR mutations detected, she was positive for the ALK rearrangement. This is the first report of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung.
Department of Thoracic Surgery, Omuta Tenryo Hospital, 1-100 Tenryo-machi, Omuta, 836-8566, Japan. ri-maruyama@omutatenryo-hp.jp.
Riichiroh
R
Maruyama
Department of Surgery, Omuta Tenryo Hospital, Omuta, Japan.
Fujio
F
Matsumura
Department of Surgery, Omuta Tenryo Hospital, Omuta, Japan.
Yuji
Y
Shibata
Department of Respiratory Medicine, Omuta Tenryo Hospital, Omuta, Japan.
Hiroshi
H
Takahashi
Department of Respiratory Medicine, Omuta Tenryo Hospital, Omuta, Japan.
Hiroko
H
Okabayashi
Department of Respiratory Medicine, Omuta Tenryo Hospital, Omuta, Japan.
Sachiyo
S
Kosai
Department of Respiratory Medicine, Omuta Tenryo Hospital, Omuta, Japan.
Izumi
I
Honda
Department of Pathology, Arao Municipal Hospital, Arao, Japan.
Susumu
S
Ohkawara
Department of Respiratory Medicine, Omuta Tenryo Hospital, Omuta, Japan.
Mineharu
M
Sugimoto
D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D000369:Aged, 80 and over; D000077548:Anaplastic Lymphoma Kinase; D001999:Bronchoscopy; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D049268:Positron-Emission Tomography; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D004273:DNA, Neoplasm; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
Anaplastic lymphoma kinase; Fluorescence in situ hybridization; Gene rearrangement; Octogenarian; Pleomorphic carcinoma