Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer.
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose, we compared the genotype and allele frequencies of the SNPs rs1467465 and rs12048235 in a group of 184 ovarian cancer patients with a control group of 184 age- and gender-matched women without any malignancy. Genotype-phenotype association revealed that A allele of SNP rs1467465 was more frequent in ovarian cancer patients than in the control group (0.40 vs. 0.33, OR 1.37, 95% CI 1.013-1.853, p = 0.04). After analysis of allele positivity we observed that A-positive genotypes were more frequent in the ovarian cancer group (0.65 vs. 0.53, OR 1.63, 95% CI 1.072-2.483, p = 0.02). Furthermore, the heterozygous genotype of rs1467465 was found to be more frequent in the patients group (0.50 vs. 0.41, OR 1.63, 95% CI 1.045-2.045, p = 0.03). No significant results were obtained with regard to SNP rs1204823. Our data suggest, that SNP rs1467465 of human gene icb-1 might affect susceptibility to ovarian cancer.
Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.
Susanne
S
Schüler
Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.
Claus
C
Lattrich
Second Department of Gynecology, Medical University of Lublin, Lublin, Poland.
Maciej
M
Skrzypczak
Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany.
Tanja
T
Fehm
Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.
Olaf
O
Ortmann
Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.
Oliver
O
Treeck
D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA
D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; C111850:THEMIS2 protein, human
Case control study; Ovarian cancer; Single nucleotide polymorphism; icb-1 gene