Palladium catalyzed C3-arylation of 4-hydroxy-2-pyridones.
The direct arylation of N-substituted-4-hydroxy-2-pyridones with aryl boronic acids has been achieved under palladium catalysis. The mild reaction conditions applied in this method and the use of a conventional catalytic system offer an attractive protocol for the efficient synthesis of a variety of 3-arylated products.
Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54124, Greece. alzograf@chem.auth.gr.
Elissavet E
EE
Anagnostaki
Anna D
AD
Fotiadou
Vera
V
Demertzidou
Alexandros L
AL
Zografos
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
D001897:Boronic Acids; D006841:Hydrocarbons, Aromatic; D011725:Pyridines; D010165:Palladium; C039659:2,4-dihydroxypyridine