Implications of Look AHEAD for clinical trials and clinical practice.
Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.
Weight Control & Diabetes Research Center, The Miriam Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
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D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009765:Obesity / Q000097:blood / Q000150:complications / Q000628:therapy*; D050177:Overweight / Q000628:therapy; D010353:Patient Education as Topic; D012107:Research Design; D040242:Risk Reduction Behavior; D011795:Surveys and Questionnaires; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014481:United States / Q000453:epidemiology; D015431:Weight Loss
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
cardiovascular disease; dietary intervention; type 2 diabetes