Carbon radical attack on a pyrimidine nitrogen. An unusual entry into polycyclic aminopyrimidones.
Unprecedented examples of a synthetically useful radical ring closure onto a pyrimidine nitrogen leading to novel, highly functionalized bi- and tricyclic pyrimidone structures are reported. An unexpected hydrogen atom translocation prior to the cyclization step was observed in some cases.
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique , 91128 Palaiseau, Cedex, France.
Ling
L
Qin
Zhibo
Z
Liu
Samir Z
SZ
Zard