Direct Radial LMHF Microvibration Induced Bone Formation and Promoted Implant Osseointegration.
BACKGROUND
Mechanical loading is known to play an important role in bone remodeling.


OBJECTIVE
This study aimed to evaluate the effect of direct low-magnitude high-frequency (LMHF) microvibration on dental implant bone formation and osseointegration.


METHODS
Titanium implants were installed in rabbit tibiae. The implants in the left legs were loaded with mechanical vibration (15 μm) at 10, 20, 30, and 40 Hz (10, 20, 30, and 40 Hz groups, respectively) for 30 minutes every day. The implants on the right legs were used as a sham control and did not receive a vibration load.


RESULTS
After 20 days, the 10, 20, and 30 Hz groups showed significantly greater newly formed bone volume, density, ratio of the bone surface area to the trabecular bone surface area, and ratio of the bone surface area in direct contact with osteoclasts versus the total bone surface area in the region of interest compared with the sham control group, especially the 20 Hz group. However, the 40 Hz group did not.


CONCLUSIONS
In conclusion, the application of direct LMHF (10, 20, or 30 Hz) vibration on the implants promoted bone formation and osseointegration, especially at 20 Hz; however, the use of 40 Hz did not result in any significant improvement.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Shirui
S
Wang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yang
Y
Liu
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yi
Y
Tang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wei
W
Zhao
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Junying
J
Li
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yang
Y
Yang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wen
W
Du
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Haiyang
H
Yu
D000818:Animals; D015519:Bone Density; D015921:Dental Implants; D016348:Osseointegration; D010012:Osteogenesis; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia; D014025:Titanium
D015921:Dental Implants; D014025:Titanium
LMHF; bone formation; dental implant; microvibration; osseointegration