Double C-F bond activation through β-fluorine elimination: nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes.
The nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes afforded fluorine-containing multi-substituted cyclopentadienes in a regioselective manner. This reaction involves the consecutive two C-F bond cleavage of a trifluoromethyl or a pentafluoroethyl group through β-fluorine elimination.
Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571 (Japan) http://www.chem.tsukuba.ac.jp/junji/index.html.
Tomohiro
T
Ichitsuka
Takeshi
T
Fujita
Tomohiro
T
Arita
Junji
J
Ichikawa
CF bond activation; alkynes; cycloaddition; cyclopentadienes; fluoroalkenes; nickel