Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses.
A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O·2(-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97 ± 1.56 and 11.70 ± 1.58 μM, respectively.
Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chia-Wei
CW
Ting
Tsong-Long
TL
Hwang
Ih-Sheng
IS
Chen
Ming-Jen
MJ
Cheng
Ping-Jyun
PJ
Sung
Ming-Hong
MH
Yen
Jih-Jung
JJ
Chen
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010196:Pancreatic Elastase / Q000276:immunology
D000893:Anti-Inflammatory Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C000594300:garcimultiflorone G; D009240:N-Formylmethionine Leucyl-Phenylalanine; D010196:Pancreatic Elastase
Biological activity; Garcimultiflorone G; Garcinia multiflora