[Analysis of pathologic characteristics and prognosis in different subtypes of adult medulloblastoma].
OBJECTIVE
To study the pathologic characteristics and prognosis in different subtypes of adult medulloblastoma (MB).


METHODS
The clinical information, imaging findings and pathologic characteristics of 151 cases of adult medulloblastomas were retrospectively reviewed and analyzed by chi-square test. The survival data were assessed using the Kaplan-Meier method.


RESULTS
Amongst the 151 MB cases studied, there were 73 cases of classic MB, 36 cases of desmoplastic/nodular MB, 39 cases of anaplastic MB and 3 cases of large cell MB. The primary tumors were more frequently located in cerebral hemisphere in desmoplastic/nodular MB than in other subtypes (P=0.000).On the other hand, large cell/anaplastic MB were associated with more frequently local recurrence and distant metastasis (P=0.003). The post-operative overall survival time ranged from 6 to 150 months, with median survival being (103.3±5.7) months (95%CI, 92.52 to 115.09). The median survival of classic MB, desmoplastic/nodular MB and large cell/anaplastic MB was (110.7±7.8) months, (125.5±7.6) months and (57.6±7.6) months, respectively. The differences were statistically significant (P=0.000).


CONCLUSIONS
The three variants of MB show different biologic behavior. Large cell/anaplastic MB represents an independent poor prognostic indicator in adults.
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
Fu
F
Zhao
Jing
J
Zhang
Xingchao
X
Wang
Zhenmin
Z
Wang
Ying
Y
Wang
Peiran
P
Qu
Lin
L
Luo
Department of Neurosurgery, Beijing Tiantan Hospital, Affilitated of Capital Medical University, Beijing 100050, China. E-mail: pinanliu@gmail.com.
Pinan
P
Liu
D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000145:classification / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008527:Medulloblastoma / Q000145:classification / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D016708:Synaptophysin / Q000378:metabolism; D055815:Young Adult
D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase