Better Osteoporotic Fracture Healing with Sintered Dicalcium Pyrophosphate (SDCP) Treatment: A Rat Femoral Fracture Model.
The aim of this study was to evaluate the effect of sintered dicalcium pyrophosphate (SDCP) on fracture healing in an osteoporotic rat model. Female Sprague-Dawley rats (8 weeks old) were randomly allocated into five groups: sham-operated group, and bilateral ovariectomized group treated with SDCP, alendronate, calcitonin, or no treatment. Rats were sacrificed at 6 or 16 weeks after fracture. Fracture sites were examined by microcomputed tomography (microCT), histology, and mechanical testing. The results showed that SDCP mildly suppressed callus remodeling at 6 weeks, but not at 16 weeks. The lamellar bone in the callus area and new cortical shell formation in SDCP-treated group were similar to that of the sham group at 16 weeks after fracture, indicating there was no delayed callus remodeling into lamellar bone. At both 6 and 16 weeks after fracture, ultimate stress and elastic modulus were similar between the SDCP and sham groups, and the mechanical strength in these groups was better than that in other groups. Finally, analysis of the serum bone markers CTX-1 and P1NP suggested that SDCP decreased the bone turnover rate and promoted proper fracture healing. The effect of SDCP is superior to that of alendronate and calcitonin in the healing of osteoporotic fractures.
Institute of Clinical Medicine (YJK, JSS) National Yang Ming University, Taipei, TaiwanInstitute of Microbiology and Immunology (CHC) National Yang Ming University, Taipei, TaiwanInstitute of Traditional Medicine (THT, YHT) National Yang Ming University, Taipei, TaiwanDepartment of Orthopaedics (YJK), School of Medicine, College of MedicineGraduate Institute of Clinical Medicine (JSS, GR), School of Medicine, College of MedicineDepartment of Orthopaedics, Shang-Ho Hospital (GR, CHC, YHT) Taipei Medical University, Taipei, TaiwanDepartment of Orthopaedic Surgery, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS)Department of Orthopaedics, Shang-Ho Hospital (CHC, GR, YHT)Department of Orthopaedics, School of Medicine, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS).
Yi-Jie
YJ
Kuo
Institute of Clinical Medicine (YJK, JSS) National Yang Ming University, Taipei, TaiwanInstitute of Microbiology and Immunology (CHC) National Yang Ming University, Taipei, TaiwanInstitute of Traditional Medicine (THT, YHT) National Yang Ming University, Taipei, TaiwanDepartment of Orthopaedics (YJK), School of Medicine, College of MedicineGraduate Institute of Clinical Medicine (JSS, GR), School of Medicine, College of MedicineDepartment of Orthopaedics, Shang-Ho Hospital (GR, CHC, YHT) Taipei Medical University, Taipei, TaiwanDepartment of Orthopaedic Surgery, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS)Department of Orthopaedics, Shang-Ho Hospital (CHC, GR, YHT)Department of Orthopaedics, School of Medicine, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS) drjssun@gmail.com.
Jui-Sheng
JS
Sun
Institute of Clinical Medicine (YJK, JSS) National Yang Ming University, Taipei, TaiwanInstitute of Microbiology and Immunology (CHC) National Yang Ming University, Taipei, TaiwanInstitute of Traditional Medicine (THT, YHT) National Yang Ming University, Taipei, TaiwanDepartment of Orthopaedics (YJK), School of Medicine, College of MedicineGraduate Institute of Clinical Medicine (JSS, GR), School of Medicine, College of MedicineDepartment of Orthopaedics, Shang-Ho Hospital (GR, CHC, YHT) Taipei Medical University, Taipei, TaiwanDepartment of Orthopaedic Surgery, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS)Department of Orthopaedics, Shang-Ho Hospital (CHC, GR, YHT)Department of Orthopaedics, School of Medicine, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS).
Gary
G
Rau
Institute of Clinical Medicine (YJK, JSS) National Yang Ming University, Taipei, TaiwanInstitute of Microbiology and Immunology (CHC) National Yang Ming University, Taipei, TaiwanInstitute of Traditional Medicine (THT, YHT) National Yang Ming University, Taipei, TaiwanDepartment of Orthopaedics (YJK), School of Medicine, College of MedicineGraduate Institute of Clinical Medicine (JSS, GR), School of Medicine, College of MedicineDepartment of Orthopaedics, Shang-Ho Hospital (GR, CHC, YHT) Taipei Medical University, Taipei, TaiwanDepartment of Orthopaedic Surgery, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS)Department of Orthopaedics, Shang-Ho Hospital (CHC, GR, YHT)Department of Orthopaedics, School of Medicine, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS).
Chia-Hsien
CH
Chen
Institute of Clinical Medicine (YJK, JSS) National Yang Ming University, Taipei, TaiwanInstitute of Microbiology and Immunology (CHC) National Yang Ming University, Taipei, TaiwanInstitute of Traditional Medicine (THT, YHT) National Yang Ming University, Taipei, TaiwanDepartment of Orthopaedics (YJK), School of Medicine, College of MedicineGraduate Institute of Clinical Medicine (JSS, GR), School of Medicine, College of MedicineDepartment of Orthopaedics, Shang-Ho Hospital (GR, CHC, YHT) Taipei Medical University, Taipei, TaiwanDepartment of Orthopaedic Surgery, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS)Department of Orthopaedics, Shang-Ho Hospital (CHC, GR, YHT)Department of Orthopaedics, School of Medicine, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS).
Tung-Hu
TH
Tsai
Institute of Clinical Medicine (YJK, JSS) National Yang Ming University, Taipei, TaiwanInstitute of Microbiology and Immunology (CHC) National Yang Ming University, Taipei, TaiwanInstitute of Traditional Medicine (THT, YHT) National Yang Ming University, Taipei, TaiwanDepartment of Orthopaedics (YJK), School of Medicine, College of MedicineGraduate Institute of Clinical Medicine (JSS, GR), School of Medicine, College of MedicineDepartment of Orthopaedics, Shang-Ho Hospital (GR, CHC, YHT) Taipei Medical University, Taipei, TaiwanDepartment of Orthopaedic Surgery, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS)Department of Orthopaedics, Shang-Ho Hospital (CHC, GR, YHT)Department of Orthopaedics, School of Medicine, National Taiwan University Hospital Hsin Chu Branch, Hsin-Chu, Taiwan (JSS).
Yang-Hwei
YH
Tsuang
D000818:Animals; D002131:Calcium Pyrophosphate / Q000627:therapeutic use*; D011756:Diphosphates / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D017102:Fracture Healing; D055595:Mechanical Phenomena; D010024:Osteoporosis / Q000150:complications*; D017207:Rats, Sprague-Dawley; D055114:X-Ray Microtomography
D011756:Diphosphates; D004338:Drug Combinations; C476842:sintered beta-dicalcium pyrophosphate; C003319:sodium pyrophosphate; D002131:Calcium Pyrophosphate
alendronate; bone remodeling; calcitonin; fracture healing; sintered dicalcium pyrophosphate (SDCP)