A stiffness-mediated oncogenic hammer.
A recent study in Nature Medicine identified a tissue stiffness-induced microRNA that mediates oncogenic signaling; its expression stratifies luminal breast cancer survivors to predict accelerated metastatic relapse.
Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. cghajar@fhcrc.org.
Cyrus M
CM
Ghajar
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D004548:Elasticity; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D040542:Mechanotransduction, Cellular; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009857:Oncogenes
C522576:MIRN18A microRNA, human; D035683:MicroRNAs