[Some peculiarities in the manifestation of oxidative stress and current status of antioxidant system in adolescents of different age groups with obesity, complicated by insulin resistance and without it].
The study has shown that neuroendocrine obesity in adolescents is associated with the formation of oxidative stress which is more pronounced in early than in late puberty. Obesity with concomitant insulin resistance increases manifestations of oxidative stress accompanied by a compensatory increase in the activity of catabolic enzymes and reduced capacity of the defense antioxidant system in late puberty. These alterations may be caused by age-related changes in hormonal secretion under conditions of insulin resistance in late puberty.
D K
DK
Kuleshova
V V
VV
Davydov
D000293:Adolescent; D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008550:Melatonin / Q000652:urine; D009765:Obesity / Q000097:blood / Q000201:enzymology / Q000378:metabolism* / Q000652:urine; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D007328:Insulin; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D008550:Melatonin
antioxidant system; neuroendocrine obesity; oxidative stress; puberty