Role of hypothermic machine perfusion in liver transplantation.
Machine liver perfusion has significantly evolved during the last ten years to optimize extended criteria liver grafts and to address the worldwide organ shortage. This review gives an overview on available ex vivo and in vivo data on hypothermic machine liver perfusion. We discuss also possible protective pathways and show most recent clinical applications of hypothermic machine liver perfusion in human.
Department of Visceral Surgery and Transplantation, Swiss HPB and Transplant Center, University Hospital Zurich, Zurich, Switzerland.
Andrea
A
Schlegel
Department of Visceral Surgery and Transplantation, Swiss HPB and Transplant Center, University Hospital Zurich, Zurich, Switzerland.
Philipp
P
Dutkowski
D000818:Animals; D003080:Cold Temperature; D006801:Humans; D008099:Liver / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation / Q000295:instrumentation / Q000379:methods*; D008928:Mitochondria / Q000473:pathology; D009926:Organ Preservation / Q000295:instrumentation / Q000379:methods*; D019188:Organ Preservation Solutions; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D010477:Perfusion / Q000295:instrumentation* / Q000379:methods; D013696:Temperature; D013997:Time Factors; D009927:Tissue and Organ Procurement
D019188:Organ Preservation Solutions; D010100:Oxygen
hypothermic oxygenated machine perfusion; marginal livers; oxygen; protective mechanisms