Aldehyde dehydrogenase 1 (ALDH1) positivity correlates with poor prognosis in cervical cancer.
OBJECTIVE
To analyse the associations between aldehyde dehydrogenase 1 (ALDH1) tumour immunopositivity and disease-free survival in cervical carcinoma.


METHODS
ALDH1 immunohistochemistry was performed on formalin-fixed, paraffin wax-embedded cervical tumour tissue samples obtained from hospital archives. Data regarding disease-free survival were obtained. Kaplan-Meier survival analyses and Cox proportional hazards regression models were performed.


RESULTS
Patients with ALDH1-positive tumours (n = 31) had significantly shorter disease-free survival than those with ALDH1-negative tumours (n = 167; 41.99 ± 0.90 vs 53.64 ± 2.67 months). ALDH1 positivity was associated with poor prognosis (relative risk 2.727; 95% confidence intervals 1.253, 5.914).


CONCLUSIONS
ALDH1 positivity is associated with poor prognosis of cervical carcinoma, and may be an independent predictor of prognosis.
Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China Key Laboratory of Malignant Tumour Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Tingting
T
Yao
Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Zhuna
Z
Wu
Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Yukun
Y
Liu
Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Qunxian
Q
Rao
Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China linzhongqiu@hotmail.com.
Zhongqiu
Z
Lin
D000328:Adult; D000368:Aged; D000080924:Aldehyde Dehydrogenase 1 Family; D002681:China; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology; D050697:Retinal Dehydrogenase / Q000378:metabolism*; D015996:Survival Rate; D016707:Tissue Fixation; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology*; D055815:Young Adult
D007527:Isoenzymes; D000080924:Aldehyde Dehydrogenase 1 Family; C510223:ALDH1A1 protein, human; D050697:Retinal Dehydrogenase
Cervical cancer; aldehyde dehydrogenase 1 (ALDH1); cancer stem cell; immunohistochemistry