The target cell genus does not matter.
Two type VI secreted phospholipases D of Pseudomonas aeruginosa were identified as trans-kingdom virulence effectors, targeting both prokaryotic and eukaryotic host cells. Each of them triggers killing bacterial competitors and internalization into non-phagocytic cells. These type VI lipolytic enzymes are widely distributed among pathogens and may constitute a conserved strategy.
CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée (IMM), Marseille, France. Electronic address: bleves@imm.cnrs.fr.
Sophie
S
Bleves
CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée (IMM), Marseille, France.
Thibault G
TG
Sana
CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée (IMM), Marseille, France.
Romé
R
Voulhoux
D018407:Bacterial Physiological Phenomena; D005057:Eukaryotic Cells / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D056265:Microbial Interactions; D010739:Phospholipase D / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D015398:Signal Transduction
D010739:Phospholipase D