Value of oncogenes for the prediction of brain metastases at initial diagnosis: a review of published data.
Identifying cancer patients who are at high risk of developing brain metastases at initial diagnosis and applying effective intervention or monitoring strategies is of vital importance. Recent advances in the biology of brain metastases revealed that some oncogenes from primary tumors may be potential markers for identifying cancer patients likely to metastasize to the brain. We here summarize data on the mechanisms of brain metastases supporting the involvement of oncogene changes in the brain metastatic evolution. We also review the available evidence on clinical studies of oncogenes in the prediction of cancer patients with high incidence of brain metastases.
Department of Oncology, Fuzhou General Hospital, Fujian - China.
Qian
Q
Huang
Xuenong
X
Ouyang
D014408:Biomarkers, Tumor / Q000235:genetics*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000556:secondary*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D009857:Oncogenes / Q000235:genetics*
D014408:Biomarkers, Tumor