Outcomes and patterns of care in adult skull base chordomas from the Surveillance, Epidemiology, and End Results (SEER) database.
This study aims to demonstrate survival rates and treatment patterns among patients with chordomas of the skull base using a large population database. Patients with cranial chordomas between 1973 and 2009 were identified from the USA Surveillance, Epidemiology, and End Results (SEER) public use database. Kaplan-Meier analysis was used to examine the effect of surgery and radiation on overall survival. We identified 394 patients with histologically-confirmed cranial chordomas. Median survival was 151 months. Most patients (89.09%) underwent surgery. Less than half (44.92%) received radiation after diagnosis. Patients who underwent surgical resection survived significantly longer than those who did not undergo resection, regardless of other treatments (151 versus 81 months, p<0.001). Ten year survival was lower among patients receiving radiation (44.8% versus 61.4%, p=0.66). Surgery predicted better overall survival by univariate analysis (hazard ratio [HR] 0.603, p=0.0293); younger age at diagnosis (HR 1.028, p<0.001), and later year of diagnosis (HR 0.971, p=0.0027) were prognostic of improved survival in a multivariate model. In subgroup analysis of patients with documented tumor size, smaller tumor size (HR 1.021, p=0.0067), younger age (HR 1.031, p=0.001), and treatment within a higher volume registry (HR 0.490, p=0.0129) predicted improved survival. Surgical intervention offers survival benefit for cranial chordomas. Findings of decreased survival in patients receiving radiation may be associated with selection. Studies examining surgical extent of resection data and radiation details are needed to determine the impact of radiotherapy.
Department of Neurosurgery, Stephen L. Harris Center for Chordoma Care, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E-9026, Boston, MA 02114, USA.
Pamela S
PS
Jones
Department of Neurosurgery, University of California, San Francisco, 5 San Francisco, CA, USA.
Manish K
MK
Aghi
Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA.
Alona
A
Muzikansky
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Helen A
HA
Shih
Department of Neurosurgery, Stephen L. Harris Center for Chordoma Care, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E-9026, Boston, MA 02114, USA.
Fred G
FG
Barker
Department of Neurosurgery, Stephen L. Harris Center for Chordoma Care, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E-9026, Boston, MA 02114, USA. Electronic address: wcurry@mgh.harvard.edu.
William T
WT
Curry
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002817:Chordoma / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019292:Skull Base Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome; D047368:Tumor Burden; D014481:United States / Q000453:epidemiology; D055815:Young Adult
Chordoma; Population study; Radiation therapy; Skull base tumors