Platelet αIIbβ3 activation: filling in the pieces.
In this issue of Blood, Kasirer-Friede and colleagues show that the adhesion and degranulation promoter protein (ADAP) promotes αIIbβ3 activation by presenting the cytoplasmic proteins talin and kindlin to the β3 cytoplasmic tail.
UNIVERSITY OF PENNSYLVANIA.
Joel S
JS
Bennett
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*; D016608:Talin / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; C477322:FERMT3 protein, human; C106957:FYB1 protein, human; C491468:Fyb protein, mouse; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D016608:Talin; C527818:kindlin-3 protein, mouse; D005340:Fibrinogen