Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasis.
A significant percentage of breast cancer victims will suffer from metastases indicating that new approaches to preventing breast cancer metastasis are thus needed. Dietary stearate (ST) and chemotherapy have been shown to reduce breast cancer metastasis. We tested the complementary use of dietary ST with a taxol-based chemotherapy which work through separate mechanisms to reduce breast cancer metastasis. We therefore carried out a prevention study in which diets were initiated prior to human MDA-MB-435 cancer cells being injected into the host and a treatment study in which diets were combined with paclitaxel (PTX). Using an orthotopic athymic nude mouse model and three diets [corn oil (CO) control diet, low fat (LF) or ST] the prevention study demonstrated that the ST diet decreased the incidence of lung metastasis by 50 % compared to both the LF and CO diets. The ST diet also reduced the number and size of metastatic lung nodules compared to the LF diet. Results of the treatment study indicated that both the CO and ST diets decreased the number of mice with lung metastasis compared to the LF diet. Both CO and ST also decreased the number of lung metastases per mouse compared to the LF diet however only the ST diet cohort was significant. Histomorphometric analysis of the lung tumor tissue indicated that the ST diet plus PTX decreased angiogenesis compared to the LF diet plus PTX. In conclusion these results support combining diet with chemotherapy in both treatment and prevention settings.
Department of Pathology, University of Alabama at Birmingham, 701 South 19th Street, LHRB Room 531, Birmingham, AL, 35294, USA.
Xiangmin
X
Zhao
Gabriel
G
Rezonzew
Dezhi
D
Wang
Gene P
GP
Siegal
Robert W
RW
Hardy
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000178:diet therapy / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000178:diet therapy / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D017239:Paclitaxel / Q000494:pharmacology / Q000627:therapeutic use; D013229:Stearic Acids / Q000008:administration & dosage; D015430:Weight Gain
D000970:Antineoplastic Agents; D013229:Stearic Acids; C031183:stearic acid; D017239:Paclitaxel