microRNAs in the tumor microenvironment: solving the riddle for a better diagnostics.
miRNAs are small noncoding RNAs with gene regulatory functions, frequently dysregulated in human cancers. Specific signatures of differentially expressed miRNAs can be used in the diagnosis of cancer and in some cases harbor prognostic implications. The biology of cancer is dictated not only by cancer cells but also by the surrounding tumor microenvironment. In particular, the role of miRNAs within the tumor microenvironment is emerging as of paramount importance. This review will focus on the current knowledge of the role of miRNAs and both cellular and stromal components of the tumor microenvironment. We will also discuss more recent findings, showing that miRNAs can be found inside of exosomes and mediate the cross-talk between cancer cells and surrounding cells, leading to the discovery of new fascinating molecular mechanisms leading to a better understanding of the cancer 'niche' and how these noncoding RNAs can become very promising diagnostic molecules.
Departments of Pediatrics and Molecular Microbiology & Immunology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Saban Research Institute, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Kishore B
KB
Challagundla
Francesca
F
Fanini
Ivan
I
Vannini
Petra
P
Wise
Mariam
M
Murtadha
Lawrence
L
Malinconico
Amelia
A
Cimmino
Muller
M
Fabbri
D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D059016:Tumor Microenvironment
D014408:Biomarkers, Tumor; D035683:MicroRNAs
biomarker; exosomes; extracellular matrix; immunity; inflammation; miRNA; stroma; toll-like receptor; tumor microenvironment