Role of hormonal levels on hospital mortality for male patients with severe traumatic brain injury.
BACKGROUND
Changes in hormone blood levels during the acute phase of traumatic brain injury (TBI) have been described in the literature. The objective was to investigate the association among several hormones plasma levels in the acute phase of severe TBI and the hospital mortality rate of male patients.


METHODS
The independent association among plasma levels of TSH, LH, FSH, GH, free T4, cortisol, IGF-1 and total testosterone was measured 10 hours and 30 hours after severe TBI and the hospital mortality of 60 consecutive male patients was evaluated.


RESULTS
At least one hormonal level abnormality was demonstrated in 3.6-73.1% of patients. The multiple logistic regressions showed a trend for an independent association among hospital mortality and normal or elevated LH levels measured at 10 hours (OR = 3.7, 95% CI = 0.8-16.3, p = 0.08) and 30 hours (OR = 3.9, 95% CI = 0.9-16.7, p = 0.06). Admission with abnormal pupils and a lower Glasgow Coma Score also were independently associated with hospital mortality.


CONCLUSIONS
The hormonal changes are frequent in the acute phase of severe TBI. The hormones plasma levels, excepting the LH, are not highly consistent with the hospital mortality of male patients.
Centro de Neurociências Aplicadas (CeNAp) .
Alexandre
A
Hohl
Marcelo Fernando
MF
Ronsoni
Rodrigo
R
Debona
Juliana
J
Ben
Marcelo Liborio
ML
Schwarzbold
Alexandre Paim
AP
Diaz
Maria Emília Rodrigues de Oliveira
ME
Thais
Marcelo Neves
MN
Linhares
Alexandra
A
Latini
Rui Daniel
RD
Prediger
Felipe Dal
FD
Pizzol
Roger
R
Walz
D000293:Adolescent; D000309:Adrenal Insufficiency / Q000097:blood* / Q000209:etiology / Q000401:mortality; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001930:Brain Injuries / Q000097:blood* / Q000150:complications / Q000401:mortality; D005640:Follicle Stimulating Hormone / Q000097:blood; D015600:Glasgow Coma Scale; D006728:Hormones / Q000097:blood*; D017052:Hospital Mortality; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007006:Hypogonadism / Q000097:blood* / Q000209:etiology / Q000401:mortality; D015601:Injury Severity Score; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D015415:Biomarkers; D006728:Hormones; D019382:Human Growth Hormone; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D006854:Hydrocortisone
Hormones; hospital mortality; male; prognosis; severe traumatic brain injury