Alkylations and hydroxymethylations of pyrazines via green Minisci-type reactions.
A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl)pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.
Research School of Chemistry and ‡Research School of Biology, The Australian National University , Canberra, ACT 0200, Australia.
Bjorn
B
Bohman
Benjamin
B
Berntsson
Ruby C M
RC
Dixon
Craig D
CD
Stewart
Russell A
RA
Barrow
D000478:Alkylation; D000818:Animals; D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D007313:Insecta / Q000737:chemistry; D015394:Molecular Structure; D010675:Pheromones / Q000737:chemistry; D010944:Plants / Q000737:chemistry; D011719:Pyrazines / Q000737:chemistry*
D001688:Biological Products; D010675:Pheromones; D011719:Pyrazines