Trifluoromethylation of Heterocycles in Water at Room Temperature.
Using a reaction medium containing nanoparticles consisting of commercially available TPGS-750-M in water, a combination of Langlois' reagent andt-BuOOH can be used to effect trifluoromethylation of several heterocyclic arrays, including heteroaromatics. These reactions take place at ambient temperatures, and the aqueous medium can be recycled.
Department of Chemistry & Biochemistry, University of California Santa Barbara 93106.
James C
JC
Fennewald
Department of Chemistry & Biochemistry, University of California Santa Barbara 93106.
Bruce H
BH
Lipshutz