Effects of dietary choline availability on latent inhibition of flavor aversion learning.
OBJECTIVE
It has been previously reported that dietary choline supplementation might affect latent inhibition (LI) using a conditioned suppression procedure in rats. We have assessed the effect of dietary choline on LI of flavor aversion learning.


METHODS
Adult male Wistar rats received a choline supplemented (5 g/kg), deficient (0 g/kg), or standard (1.1 g/kg) diet for 3 months. After this supplementation period, all rats went through a conditioned taste aversion (CTA) procedure, half of them being pre-exposed to the conditioned stimulus before the conditioning.


RESULTS
The results indicated that choline deficiency prevents LI of conditioned flavor aversion to cider vinegar (3%) induced by a LiCl (0.15 M; 2% body weight) intraperitoneal injection, while choline supplementation enhances CTA leading to slower extinction.


CONCLUSIONS
The role of the brain systems modulating attentional processes is discussed.
Fernando
F
Gámiz
Sergio Andrés
SA
Recio
Adela Florentina
AF
Iliescu
Milagros
M
Gallo
Isabel
I
de Brugada
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002794:Choline / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects*; D004032:Diet; D007266:Inhibition, Psychological; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013649:Taste / Q000502:physiology*
D002794:Choline
Attention; Choline; Flavor aversion; Latent inhibition; Learning; Rats