Improving photoprotection: 4-methylbenzylidene camphor microspheres.
We propose a new approach for photoprotection. 4-Methylbenzylidene camphor (4-MBC), one of the most widely used UV filters, was encapsulated in microspheres, with a view to overcoming problems (percutaneous absorption, photodegradation and lack of lasting effect) arising with organic sunscreens, and to achieve safe photoprotection. We focused on this filter in the light of the Cosmetics Europe opinion concerning its possible effects on the thyroid gland. Microspheres were prepared by emulsification-solvent evaporation, using different amounts of 4-MBC and characterized for morphology, encapsulation efficiency and particle size. The particles were then mixed in O/W emulsions. The in vitro sun protection factors, in vitro release and photostability were investigated and compared with emulsions containing the free sunscreen. The new microspheres offer good morphology and loading (up to 40%), and the same photoprotection as the free filter while at the same time protecting it from photodegradation. The systems also give a slower release from the emulsions.
a Dipartimento di Biotecnologie, Chimica e Farmacia , University of Siena , Siena , Italy and.|b Centro Interdipartimentale di Scienza e Tecnologia Cosmetiche, University of Siena , Siena , Italy.
Marisanna
M
Centini
b Centro Interdipartimentale di Scienza e Tecnologia Cosmetiche, University of Siena , Siena , Italy.
Giovanna
G
Miraglia
b Centro Interdipartimentale di Scienza e Tecnologia Cosmetiche, University of Siena , Siena , Italy.
Valeria
V
Quaranta
a Dipartimento di Biotecnologie, Chimica e Farmacia , University of Siena , Siena , Italy and.|b Centro Interdipartimentale di Scienza e Tecnologia Cosmetiche, University of Siena , Siena , Italy.
Anna
A
Buonocore
a Dipartimento di Biotecnologie, Chimica e Farmacia , University of Siena , Siena , Italy and.|b Centro Interdipartimentale di Scienza e Tecnologia Cosmetiche, University of Siena , Siena , Italy.
Cecilia
C
Anselmi
4-Methylbenzylidene camphor; microspheres; photoprotection; photostability; release; sunscreens