[Comparison liver resection with transarterial chemoembolization for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma patients on long-term survival after SPSS propensity score matching].
OBJECTIVE
To compare the long-term survival of patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) undergoing either liver resection or transarterial chemoembolization (TACE) after propensity score matching (PSM).


METHODS
One hundred sixty-seven and 70 BCLC-B HCC patients undergoing liver resection and TACE were retrospectively collected. PSM function of SPSS software was conducted to reduce confounding bias between the groups. And then survival analysis was performed for the matched data.


RESULTS
Fifty-three pairs of patients were successfully matched. And then survival analysis showed that the median survival periods and their 95% confidence intervals were 35.0 (26.3-43.7)months in the liver resection group versus 20.0(15.0-25.0) months in the TACE group. The 1, 3, 5 and 7-year survival rates were 91.0%, 49.0%, 30.0% and 17.0% in the liver resection group versus 73.0%, 25.0%, 8.0% and 5.0% respectively in the TACE group (P = 0.001). Cox regression analysis revealed that TACE, total bilirubin ≥ 34.2 µmol/L, alpha fetoprotein ≥ 400 ng/ml and tumor number ≥ 3 were independent risk factors of survival (hazard ratio >1, P < 0.05).


CONCLUSIONS
The balance of covariates may be achieved through PSM. And for patients with BCLC-B HCC, liver resection provides better long-term overall survival than TACE.
Department of Hepatobiliary Surgery, Tumor Hospital, Guangxi Medical University, Nanning 530021, China.
Yang
Y
Ke
Department of Hepatobiliary Surgery, Tumor Hospital, Guangxi Medical University, Nanning 530021, China.
Jianhong
J
Zhong
Department of Hepatobiliary Surgery, Tumor Hospital, Guangxi Medical University, Nanning 530021, China.
Zhe
Z
Guo
Department of Hepatobiliary Surgery, Tumor Hospital, Guangxi Medical University, Nanning 530021, China.
Yongrong
Y
Liang
Department of Hepatobiliary Surgery, Tumor Hospital, Guangxi Medical University, Nanning 530021, China. Email: kylw2013@126.com.
Lequn
L
Li
Department of Hepatobiliary Surgery, Tumor Hospital, Guangxi Medical University, Nanning 530021, China.
Bangde
B
Xiang
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D057216:Propensity Score; D012189:Retrospective Studies; D016896:Treatment Outcome