NDM-1-producing Enterobacteriaceae from South Africa: moving towards endemicity?
We describe 4 patients infected with NDM-1 Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens from South Africa that co-produced SHV-12, CTX-M-3, and CTX-M-15 and were positive for qnrS, qnrA, aac(6')-Ib-cr, rmtF, rmtC, and armA. Plasmids belonged to IncN, IncA/C replicon types with ccdAB and vagC/D addiction factors. Local and imported cases of NDM-producing bacteria co-exist within South Africa.
Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada; Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada.
Joseph E
JE
Rubin
Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada; Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Gisele
G
Peirano
Department of Clinical Microbiology, Lancet laboratories, Durban, KwaZulu-Natal, South Africa.
Abdool K
AK
Peer
Department of Clinical Microbiology, Lancet laboratories, Durban, KwaZulu-Natal, South Africa.
Chetna N
CN
Govind
Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada; Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. Electronic address: johann.pitout@cls.ab.ca.
Johann D D
JD
Pitout
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016971:Citrobacter freundii / Q000201:enzymology* / Q000302:isolation & purification; D019353:Endemic Diseases; D016972:Enterobacter cloacae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D012706:Serratia marcescens / Q000201:enzymology* / Q000302:isolation & purification; D013019:South Africa; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
Enterobacteriaceae; Metallo- β-lactamases; Molecular epidemiology; NDM