IL-10 and macrophages orchestrate gut homeostasis.
Macrophages in the gut originate from blood precursors and have distinct functional properties. In this issue of Immunity,Zigmond et al. (2014) and Shouval et al. (2014) report that interleukin-10 drives macrophages to express homeostatic tolerogenic functions, preventing colitis.
Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
Alberto
A
Mantovani
Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy.
Federica
F
Marchesi
D000818:Animals; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D053701:Receptors, Interleukin-10 / Q000276:immunology*
C556062:IL10 protein, mouse; D053701:Receptors, Interleukin-10; D016753:Interleukin-10