Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies.
High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.
The University of Texas M.D Anderson Cancer Center, Houston.
Dimitrios
D
Farmakiotis
The University of Texas M.D Anderson Cancer Center, Houston.
Fazal
F
Shirazi
Public Health Research Institute Center, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark.
Yanan
Y
Zhao
The University of Texas M.D Anderson Cancer Center, Houston.
Peguy J
PJ
Saad
The University of Texas M.D Anderson Cancer Center, Houston.
Nathaniel D
ND
Albert
Aristotle University of Thessaloniki, Greece.
Emmanuel
E
Roilides
New York-Presbyterian/Weill Cornell Medical Center, New York City.
Thomas J
TJ
Walsh
Public Health Research Institute Center, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark.
David S
DS
Perlin
The University of Texas M.D Anderson Cancer Center, Houston.
Dimitrios P
DP
Kontoyiannis
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001203:Ascomycota / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D004331:Drosophila melanogaster / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D008775:Methylprednisolone / Q000494:pharmacology*; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
Exserohilum rostratum; animal models; apoptosis; corticosteroids; virulence