Serum ischemia-modified albumin levels in children with epileptic seizures.
OBJECTIVE
The aim of the present study was to determine the level of ischemia-modified albumin (IMA) in children with epileptic seizures (ESs) and its relation with the seizure duration.


METHODS
The study was performed with 88 children as a prospective case-control study. Blood samples for IMA were obtained from 57 patients (mean age [SD], 50.86 [51.15] months) within 3 hours after ES and 31 healthy control subjects (mean age [SD], 53.13 [40.87] months). Ischemia-modified albumin was measured by the albumin cobalt binding test.


RESULTS
Although the mean (SD) of serum IMA level of the patients with seizure was 13.66 (13.16) U/mL, the mean (SD) of serum IMA level for the control group was 3.73 (1.93) U/mL. Ischemia-modified albumin levels were significantly higher in patients with seizure, compared with that in the control group (P < 0.01). When patients were grouped in itself according to the duration of ESs, the levels of IMA were detected to be increased in patients as the duration of seizures was lengthened.


CONCLUSIONS
Increased IMA levels after seizures suggest that IMA assay during seizure may be useful for predicting the diagnosis and severity of convulsion.
From the *Department of Pediatrics, Konya Education and Research Hospital; Departments of †Pediatric Neurology and ‡Pediatric Endocrinology, Faculty of Medicine, Necmeddin Erbakan University; Departments of §Biochemistry and ∥Pediatric Nephrology, Konya Education and Research Hospital, Konya, Turkey.
Celebi
C
Kocaoglu
Huseyin
H
Caksen
Mehmet Emre
ME
Atabek
Huseyin
H
Kurku
Sukru
S
Arslan
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014421:Turkey
D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human