Amino acids fuel T cell-mediated inflammation.
Reprogramming cellular metabolism helps support T cell growth and effector function upon activation. In this issue of Immunity, Nakaya et al. (2014) report that the glutamine transporter ASCT2 regulates T cell metabolism and mTOR kinase signaling to shape inflammatory T helper cell responses.
Goodman Cancer Research Centre, Department of Physiology, McGill University, Montreal, QC, Canada, H3G 1Y6.
Maya C
MC
Poffenberger
Goodman Cancer Research Centre, Department of Physiology, McGill University, Montreal, QC, Canada, H3G 1Y6. Electronic address: russell.jones@mcgill.ca.
Russell G
RG
Jones
D026962:Amino Acid Transport System ASC / Q000276:immunology*; D000818:Animals; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D015778:Minor Histocompatibility Antigens; D046912:Multiprotein Complexes / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
D026962:Amino Acid Transport System ASC; D015778:Minor Histocompatibility Antigens; D046912:Multiprotein Complexes; D011948:Receptors, Antigen, T-Cell; C498850:Slc1a5 protein, mouse; D005973:Glutamine; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases