Anti-MDA-5 antibody-positive bullous dermatomyositis with palmar papules complicating rapidly progressive interstitial lung disease.
We present the first case of dermatomyositis showing both vesicle formation and palmar papules. The association of bullous formation and internal malignancy, and palmar papules and interstitial lung disease (ILD) is well known in dermatomyositis, respectively. This patient presented with vesicles; however, the immunoprecipitation assays detected anti-MDA-5 antibody and the patient complicated rapidly progressive ILD, but no malignancy. We propose that palmar papules might be regarded as more critical than blister formation.
a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa, Otsu , Shiga , Japan.
Noriki
N
Fujimoto
a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa, Otsu , Shiga , Japan.
Shinichiro
S
Honda
a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa, Otsu , Shiga , Japan.
Makiko
M
Wakabayashi
b Department of Dermatology , Graduate School of Medical Science, Kanazawa University , Kanazawa , Ishikawa , Japan.
Yasuhito
Y
Hamaguchi
c Department of Dermatology , Faculty of Medicine, University of Tsukuba , Tsukuba , Ibaraki , Japan.
Manabu
M
Fujimoto
a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa, Otsu , Shiga , Japan.
Toshihiro
T
Tanaka
D001323:Autoantibodies / Q000032:analysis / Q000097:blood; D001706:Biopsy; D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006225:Hand; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1 / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology / Q000503:physiopathology
D001323:Autoantibodies; C452815:IFIH1 protein, human; D000072640:Interferon-Induced Helicase, IFIH1
Blister formation; Bullous dermatomyositis; MDA-5; Palmar papules; Vesicle