Equine placental mixed germ cell tumor with metastasis to the foal.
The placenta from an embryo transfer-recipient mare and live foal was examined. The placenta was effaced by multifocal masses, which ranged from less than 1 cm to 14 cm in diameter. The foal represented at 52 days for lethargy, ataxia, and urine dribbling; due to a poor prognosis, the foal was euthanized. At necropsy, the liver was effaced by multifocal, pale, irregular nodules. The lumbar vertebrae and other skeletal sites had multifocal lytic lesions. The placenta had 4 populations of neoplastic cells, including a spindle cell population, tall columnar and transitional epithelial cell populations, and an undifferentiated polygonal cell population. The foal's liver had similar populations and patterns of cells as those in the placenta. The lesion in the placenta and the masses in the foal were diagnosed as a mixed germ cell tumor and metastatic mixed germ cell tumor, respectively.
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa mbock@iastate.edu.
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MM
Bockenstedt
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa.
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Fales-Williams
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa.
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JS
Haynes
D000818:Animals; D000831:Animals, Newborn; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary / Q000662:veterinary*; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000662:veterinary*; D010920:Placenta / Q000473:pathology; D011247:Pregnancy
D014408:Biomarkers, Tumor
equine; mixed germ cell tumor; placenta