Personalized surgical management of colorectal cancer in elderly population.
Colorectal cancer (CRC) in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric population. In this phase of the life cycle, treatment is frequently suboptimal. Despite the fact that, nowadays, older people tend to be healthier than in previous generations, surgical undertreatment is frequently encountered. On the other hand, surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent disability. Unfortunately, due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors (heterogeneity, frailty, etc.), there is a dearth of evidence-based clinical guidelines for the management of these patients. The objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the elderly. More than in any other patient group, both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by CRC. Although cure and sphincter preservation are the primary goals, many other variables need to be taken into account, such as maintenance of cognitive status, independence, life expectancy and quality of life.
Giampaolo Ugolini, Federico Ghignone, Davide Zattoni, Giacomo Veronese, Isacco Montroni, Department of Medical and Surgical Sciences, University of Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy.
Giampaolo
G
Ugolini
Giampaolo Ugolini, Federico Ghignone, Davide Zattoni, Giacomo Veronese, Isacco Montroni, Department of Medical and Surgical Sciences, University of Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy.
Federico
F
Ghignone
Giampaolo Ugolini, Federico Ghignone, Davide Zattoni, Giacomo Veronese, Isacco Montroni, Department of Medical and Surgical Sciences, University of Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy.
Davide
D
Zattoni
Giampaolo Ugolini, Federico Ghignone, Davide Zattoni, Giacomo Veronese, Isacco Montroni, Department of Medical and Surgical Sciences, University of Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy.
Giacomo
G
Veronese
Giampaolo Ugolini, Federico Ghignone, Davide Zattoni, Giacomo Veronese, Isacco Montroni, Department of Medical and Surgical Sciences, University of Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy.
Isacco
I
Montroni
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000601:surgery*; D016330:Frail Elderly; D005853:Geriatrics / Q000379:methods; D006801:Humans; D010535:Laparoscopy; D008495:Medical Oncology / Q000379:methods; D010348:Patient Care Team; D019338:Polypharmacy; D011184:Postoperative Period; D011788:Quality of Life; D035862:Vulnerable Populations
Colorectal cancer; Elderly; Geriatric assessment; Personalized treatment; Surgery