A comparison of granules produced by high-shear and fluidized-bed granulation methods.
Placebo granules were manufactured by both wet high-shear and fluidized-bed techniques. The granules were compared based on size, shape, surface morphology, and a variety of different flowability measurements. This comparison showed that granule formation and growth were different, with induction growth for high-shear granulation and steady growth for fluidized-bed granulation. Final granules from high-shear granulation were more spherical and dense compared with the irregular granules from fluidized-bed granulation. The high-shear granules demonstrated better overall flow properties.
Biomedical Engineering, The University of Western Ontario, London, Canada, N6A 5B9.
Garett
G
Morin
Lauren
L
Briens
D002626:Chemistry, Pharmaceutical / Q000379:methods; D010316:Particle Size; D013678:Technology, Pharmaceutical / Q000379:methods*