Child externalizing behavior problems linked to genetic and non-genetic variation in dental caries.
The association of environmental and genetic variation in caries with child externalizing behavior problems (inattention, hyperactivity, impulsivity, and defiance) was studied in a sample of 239 pairs of 3- to 8-year-old impoverished Brazilian twins. It was hypothesized that externalizing problems would show a stronger positive association with environmental than genetic variation in caries. Univariate twin models were estimated to parse variation in caries into three components: additive genetic (A), shared environment (C) and non-shared environment/error (E). Age-adjusted associations between externalizing problems and each variance component were tested. Contrary to the hypothesis, modest but very consistent negative associations were found between externalizing problems and both genetic and environmental variation in caries. Mutans streptococci and sweetness preference did not explain the negative associations of caries and externalizing problems. Externalizing problems in non-medicated children were associated with less dental decay that could be explained by both genetic and environmental factors.
Department of Cariology and Comprehensive Care, New York University College of Dentistry, New York, N.Y., USA.
Michael F
MF
Lorber
Amy M
AM
Smith Slep
Richard E
RE
Heyman
Walter A
WA
Bretz
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000235:genetics; D002326:Cariogenic Agents / Q000008:administration & dosage; D002648:Child; D002653:Child Behavior Disorders / Q000235:genetics*; D002675:Child, Preschool; D004245:DMF Index; D003731:Dental Caries / Q000235:genetics*; D003743:Dental Enamel / Q000473:pathology; D003804:Dentin / Q000473:pathology; D019422:Dietary Sucrose / Q000008:administration & dosage; D004200:Diseases in Twins; D005518:Food Preferences; D059647:Gene-Environment Interaction; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics; D007175:Impulsive Behavior; D010636:Phenols; D013295:Streptococcus mutans / Q000302:isolation & purification; D014172:Transillumination; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D002326:Cariogenic Agents; D019422:Dietary Sucrose; D010636:Phenols