Design of chitosan-based nanoformulations for efficient intracellular release of active compounds.
The use of chitosan-based nanocarriers to transport active compounds gained an increasing attention in drug delivery. Intracellular delivery, with efficient intracellular release, become an important design considerations in chitosan based nanoformlations. Internal stimuli-responsive nanoformulations are designed to release active compounds after internalization based on certain internal stimuli like pH, redox potential and enzymes. Futhermore, nondestructive pathways may provide a nondigestive compartment for active compounds transport, which can protect the encapsulated agents from possible lysosomal degradation, thereby realizing release agents safely. This review gives a brief overview about the chitosan-based nanoformulations for efficient intracellular cargo release, including internal stimuli-responsive nanoformulations and nondestructive pathways based nanoformulations: design strategies and applications. The present problems and a possible future perspective related them are also discussed.
Department of Pharmaceutics, College of Pharmaceutical Sciences, Shandong University, 44 Wenhua Xilu, Jinan 250012, China.
Hongliang
H
Du
Xiaoye
X
Yang
Guangxi
G
Zhai
D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D007424:Intracellular Fluid / Q000737:chemistry* / Q000378:metabolism*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D010599:Pharmacokinetics
D053769:Nanocapsules; D004364:Pharmaceutical Preparations; D048271:Chitosan
chitosan nanoformulations; drug delivery; internal stimuli-responsive; intracellular release; nondestructive pathways