The role of BCR isotype in B-cell development and activation.
The development and function of B lymphocytes critically depend on the non-germline B-cell antigen receptor (BCR). In addition to the diverse antigen-recognition regions, whose coding sequences are generated by the somatic DNA rearrangement, the variety of the constant domains of the Heavy Chain (HC) portion contributes to the multiplicity of the BCR types. The functions of particular classes of the HC, particularly in the context of the membrane BCR, are not completely understood. The expression of the various classes of the HC correlates with the distinct stages of B-cell development, types of B-cell subsets, and their effector functions. In this chapter, we summarize and discuss the accumulated knowledge on the role of the μ, δ, and γ HC isotypes of the conventional and precursor BCR in B-cell differentiation, selection, and engagement with (auto)antigens.
Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany; Department of Molecular immunology, Faculty of Biology, University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Elena
E
Surova
Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany; Department of Molecular immunology, Faculty of Biology, University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany; Department of Immunology, Ulm University, Ulm, Germany. Electronic address: hassan.jumaa@uni-ulm.de.
Hassan
H
Jumaa
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000145:classification / Q000276:immunology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000145:classification* / Q000235:genetics; D007138:Immunoglobulin delta-Chains / Q000145:classification / Q000235:genetics; D007142:Immunoglobulin gamma-Chains / Q000145:classification / Q000235:genetics; D007148:Immunoglobulin mu-Chains / Q000145:classification / Q000235:genetics; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000145:classification* / Q000276:immunology* / Q000378:metabolism
D007132:Immunoglobulin Isotypes; D007138:Immunoglobulin delta-Chains; D007142:Immunoglobulin gamma-Chains; D007148:Immunoglobulin mu-Chains; D011947:Receptors, Antigen, B-Cell
Autoreactivity; B-cell development; Heavy-chain isotype; Immunoglobulin