Tandem CCCH zinc finger proteins in plant growth, development and stress response.
Cysteine3Histidine (CCCH)-type zinc finger proteins comprise a large family that is well conserved across eukaryotes. Among them, tandem CCCH zinc finger proteins (TZFs) play critical roles in mRNA metabolism in animals and yeast. While there are only three TZF members in humans, a much higher number of TZFs has been found in many plant species. Notably, plant TZFs are over-represented by a class of proteins containing a unique TZF domain preceded by an arginine (R)-rich (RR) motif, hereafter called RR-TZF. Recently, there have been a large number of reports indicating that RR-TZF proteins can localize to processing bodies (P-bodies) and stress granules (SG), two novel cytoplasmic aggregations of messenger ribonucleoprotein complexes (mRNPs), and play critical roles in plant growth, development and stress response, probably via RNA regulation. This review focuses on the classification and most recent development of molecular, cellular and genetic analyses of plant RR-TZF proteins.
Department of Horticulture and Crop Science, The Ohio State University, Columbus, OH 43210, USA.
Srimathi P
SP
Bogamuwa
Department of Horticulture and Crop Science, The Ohio State University, Columbus, OH 43210, USADepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USACenter for Applied Plant Sciences, The Ohio State University, Columbus, OH 43210, USA Jang.40@osu.edu.
Jyan-Chyun
JC
Jang
D063245:Plant Development; D010940:Plant Proteins / Q000145:classification* / Q000235:genetics; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D018749:RNA, Plant / Q000378:metabolism; D013312:Stress, Physiological; D020080:Tandem Repeat Sequences; D016335:Zinc Fingers
D010940:Plant Proteins; D018749:RNA, Plant
Arginine-rich motif; P-body and stress granules; RNA binding; RNA decay; RR-TZF protein; Tandem CCCH zinc finger proteins