Pseudogene-derived endogenous siRNAs and their function.
Pseudogenes were once considered genomic fossils, but recent studies indicate that they may function as gene regulators through the generation of endogenous small interfering RNAs (esiRNAs), antisense RNAs, and decoys for microRNAs. In this review, we summarize pseudogene study methods, emphasizing relevant publicly available resources, and we describe a systematic pipeline to identify pseudogene-derived esiRNAs and their targets, which can lead to a deeper understanding of pseudogene function.
Biomedical Informatics, Asia University, Taichung, Taiwan.
Wen-Ling
WL
Chan
Jan-Gowth
JG
Chang
D000818:Animals; D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D055106:Genome-Wide Association Study; D006801:Humans; D058977:Molecular Sequence Annotation; D011544:Pseudogenes / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism; D064878:Web Browser
D034741:RNA, Small Interfering