Urinary tract infection caused by Enterococcus isolates: aetiology and antimicrobial resistance patterns.
The purpose of this study was to analyse the data on resistance in Enterococcus faecalis and E. faecium isolated from urine samples of inpatients from January 2010 to December 2013. Compared to E. faecalis, E. faecium isolates were significantly more resistant to ampicilin, nitrofurantoin, and ciprofloxacin in the antimicrobial agents evaluated. Both species showed higher resistance to high-level gentamicin. The rate of vancomycin-resistant enterococci (VRE) in E. faecium was higher as compared to that of E. faecalis, and we found that apparent increase in the frequency of VRE E. faecalis clinical isolates in the 4-year study period. In our study, analysis of the antimicrobial resistance trends showed resistance to linezolid and vancomycin were <30.2% and <20.3% in both species, respectively. Of noteworthy is the high rate of MDR in two species from inpatients. This study highlights that it is of importance for clinicians to promote rational drug utilization and delay the emergence of resistant organisms.
Qing-Yong
QY
Wang
Rong-Hai
RH
Li
Xiao-Hong
XH
Shang
D000046:Academic Medical Centers; D000668:Ampicillin Resistance; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D002681:China; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D057286:Electronic Health Records; D013293:Enterococcus faecalis / Q000187:drug effects / Q000302:isolation & purification*; D016984:Enterococcus faecium / Q000187:drug effects / Q000302:isolation & purification*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology* / Q000652:urine; D006801:Humans; D009582:Nitrofurantoin / Q000494:pharmacology; D012189:Retrospective Studies; D013045:Species Specificity; D014552:Urinary Tract Infections / Q000382:microbiology* / Q000652:urine
D000892:Anti-Infective Agents, Urinary; D002939:Ciprofloxacin; D009582:Nitrofurantoin
Antimicrobial resistance,; Enterococcus spp.,; Urinary tract infection