Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity.
Acrylic copolymers with appropriate compositions of counits having cationic charge with 2-carbon and 6-carbon spacer arms can show superior antibacterial activities with concomitant very low hemolytic effect. These amphiphilic copolymers represent one of the most promising synthetic polymer antibacterial systems reported.
Center for Engineered Polymeric Materials, Department of Chemistry, College of Staten Island, City University of New York, 2800 Victory Blvd, Staten Island, New York 10314, USA. NanLoh.Yang-cepm@csi.cuny.edu.
Ashish
A
Punia
Edward
E
He
Kevin
K
Lee
Probal
P
Banerjee
Nan-Loh
NL
Yang
D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002462:Cell Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; C006903:carbopol 940