Wound healing potential of pterospermum acerifolium wild. With induction of tumor necrosis factor - α.
Pterospermum acerifolium, a well-known plant in Indian medicine possesses various therapeutic properties including healing properties and cytokine induction. Wound healing activity of ethanolic extract of P. acerifolium flower along with its effect on tumor necrosis factor-α (TNF-α) was assessed using excision model of wound repair in Wistar albino rats. After application of the P. acerifolium extract, rate of epithelization with an increase in wound contraction was observed. Animals tropically treated with 10% P. acerifolium extract in petroleum jelly, the wound healing process was observed faster as compared to control group which were treated with petroleum jelly alone. A significant accelerated healing was noticed in animals which were additionally prefed with 250mg/kg body weight of ethanolic P. acerifolium extract daily for 20 consecutive days along with the topical application 10% P. acerifolium extract. During wound healing phase TNF-α level was found to be up regulated by P. acerifolium treatment. Early wound healing may be pronounced due to P. acerifolium extract elevating TNF-α production.
Institute of Pharmacy and Technology Salipur, Cuttack, Orissa, 754202, India.
Aswini Kumar
AK
Senapati
Institute of Pharmacy and Technology Salipur, Cuttack, Orissa, 754202, India.
Ranjan Kumar
RK
Giri
Royal College of Pharmacy and Health Sciences, Berhampur, 760 001, India.
Dibya Sundar
DS
Panda
AU college of Pharmaceutical sciences, Andhra University, Visakhapatnam, 530003, India.
Sremantula
S
Satyanarayan
Cytokine induction; Pterospermum acerifolium; TNF-α; wound healing