Impact of IL-10 (-1082) promoter-single nucleotide polymorphism on the outcome of hepatitis C virus genotype 4 infection.
Immunoregulatory cytokines may influence the hepatitis C virus (HCV) infection outcome. This study aimed to determine the genotypic and allelic frequencies of the interleukin (IL)-10 (-1082) G/A polymorphism, and its association with chronicity or resolution of HCV genotype 4 infection in Egypt. The frequencies of different dimorphic polymorphisms based on single nucleotide substitution in chronic HCV patients (50) and resolved HCV patients (50) were: IL-10 (-1082) G/G 22 (44%) and 18 (36%), G/A 19 (38%) and 24 (48%), and A/A 9 (18%), and 8 (16%), respectively. In the sustained virologic response (SVR) (36) and spontaneously resolved subjects (14) groups, the frequencies were: IL-10 (-1082) G/G 11 (30.6%) and 7 (50%) G/A 18 (50%) and 6 (42.9%), A/A 7 (19.4%) and 1 (7.1%), respectively. An association between male gender and chronic hepatitis C outcome (P value 0.041) was found. However, no significant gender difference was found when we compared females versus males with elevated alanine transaminase (ALT) levels in the chronic HCV patient group (P value = 1).


CONCLUSIONS
No significant difference in the frequency of IL-10 single nucleotide polymorphism (SNP) at position 1082 was found between chronic and resolved HCV subjects.
Virology and Clinical Pathology Department, Cairo University, Egypt.
Soheir F
SF
Helal
Clinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Howayda E
HE
Gomaa
Clinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Eman H
EH
Thabet
Virology and Clinical Pathology Department, Cairo University, Egypt.
Mariam A
MA
Younan
Clinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Neveen A
NA
Helmy
HCV genotype 4; chronic hepatitis C; interleukin-10; resolved hepatitis C; single nucleotide polymorphism