Bridging the gaps between the histopathological and demographic risk factors of preterm birth in a unique Miami inner-city population.
We aim to identify the link between placental histological findings and obstetric reports to determine possible risk factors of spontaneous preterm birth (SPTB). We prospectively ascertained birth records and outcomes from all deliveries in our hospital in 1 year. Records were used to determine and stratify for either full-term or preterm [spontaneous or indicated (I)] deliveries. We analyzed for risk factor association using χ(2) tests and common odds ratio estimates (SPSS v21.0). Our cohort totaled 6088 deliveries: 236 IPTB, 43 SPTB, and 5809 term births. Largely Hispanic, we determined race, parity, prenatal care access, preeclampsia, gestational diabetes, and BMI to be highly associated with SPTB (p < 0.01). Histologically, placentas of women with SPTB were twice as likely to have chronic villitis. We found that chronic villitis is associated with SPTB. Results of this study can be used in increasing the understanding of SPTB.
1Department of Human Genetics, University of Miami, Miami, FL, USA.
Muthu Kumar
MK
Veerapen
Liset
L
Pelaez
JoNell Efantis
JE
Potter
Lunthita
L
Duthely
Rhea
R
Birusingh
Evadnie
E
Rampersaud
Olaf A
OA
Bodamer
Maria Matilde
MM
Rodriguez
D000328:Adult; D015331:Cohort Studies; D003710:Demography; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000473:pathology; D010922:Placenta Diseases / Q000453:epidemiology / Q000473:pathology; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D011295:Prenatal Care; D011446:Prospective Studies; D012307:Risk Factors; D014505:Urban Population; D055815:Young Adult
chronic villitis; obstetrics; placenta; premature; spontaneous preterm birth