Coagulation profile in patients with H1N1 influenza A infection undergoing treatment for haematological malignancies.
Patients with haematological malignancies receiving concurrent treatment or after allogeneic stem cell transplantation (HSCT) are considered to be at increased risk for acquiring influenza A (H1N1) infection (pH1N1) and influenza-associated complications leading to increased mortality. We report of a series of haematological patients with severe course of laboratory-confirmed pH1N1, including two patients after HSCT. Coagulation assays were conducted and the association between coagulation activation and poor outcome pH1N1 infection was found in the analyzed group.
Department of Haematology, Poznan University of Medical Sciences, Poznań, Poland.
Joanna
J
Rupa-Matysek
Lidia
L
Gil
Ewelina
E
Wojtasińska
Katarzyna
K
Zajdel
Katarzyna
K
Ciepłuch
Mieczysław
M
Komarnicki
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology; D007251:Influenza, Human / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D014184:Transplantation, Homologous
D000970:Antineoplastic Agents; D015415:Biomarkers