[The relevance of PET/CT for the surgical management of neuroendocrine neoplasms].
Neuroendocrine neoplasms (NEN) are rare malignancies with a wide spectrum of metastatic potential which originate from the endocrine cells of the body and express somatostatin receptors. The (68)gallium somatostatin receptor positron emission tomography-computed tomography (PET/CT) technique is the most sensitive method of assessment of well-differentiated NENs and for the detection of cancer of unknown primary (CUP syndrome) NENs. Imaging with 18F-fluorodeoxyglucose (18F-FDG PET/CT) is indicated in poorly differentiated neuroendocrine carcinomas. The receptor-dependent imaging of NENs has a decisive impact on further management.
Klinik für Allgemeine Chirurgie/Viszeralchirurgie, ENETS Center of Excellence/Zentralklinik Bad Berka, Robert-Koch-Allee 9, 99438, Bad Berka, Deutschland, avc@zentralklinik.de.
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Hommann
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Kaemmerer
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Hörsch
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Kulkarni
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Robiller
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Baum
D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000601:surgery; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D049268:Positron-Emission Tomography / Q000379:methods*; D017481:Receptors, Somatostatin; D012680:Sensitivity and Specificity; D013004:Somatostatin; D014057:Tomography, X-Ray Computed / Q000379:methods*
D005710:Gallium Radioisotopes; D017481:Receptors, Somatostatin; D019788:Fluorodeoxyglucose F18; D013004:Somatostatin