Advances in systems biology approaches for autoimmune diseases.
Because autoimmune diseases (AIDs) result from a complex combination of genetic and epigenetic factors, as well as an altered immune response to endogenous or exogenous antigens, systems biology approaches have been widely applied. The use of multi-omics approaches, including blood transcriptomics, genomics, epigenetics, proteomics, and metabolomics, not only allow for the discovery of a number of biomarkers but also will provide new directions for further translational AIDs applications. Systems biology approaches rely on high-throughput techniques with data analysis platforms that leverage the assessment of genes, proteins, metabolites, and network analysis of complex biologic or pathways implicated in specific AID conditions. To facilitate the discovery of validated and qualified biomarkers, better-coordinated multi-omics approaches and standardized translational research, in combination with the skills of biologists, clinicians, engineers, and bioinformaticians, are required.
Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul 143-729, Korea.
Ho-Youn
HY
Kim
Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143-729, Korea.
Hae-Rim
HR
Kim
Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143-729, Korea.
Sang-Heon
SH
Lee
Autoimmune diseases; Biomarker; Multi-omics; Network analysis; Systems biology; Translational research