14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends.
Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).
Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, London, UK. Electronic address: maria.bertolaccini@kcl.ac.uk.
Maria Laura
ML
Bertolaccini
Department of Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
Olga
O
Amengual
Department of Clinical and Experimental Sciences, University of Brescia, Italy; Rheumatology and Clinical Immunology Unit, Spedali Civili, Brescia, Italy.
Laura
L
Andreoli
Department of Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
Tatsuya
T
Atsumi
Division of Rheumatology, Department of Clinical Sciences and Community Health, University of Milan, Italy; Experimental Laboratory of Immunorheumatology, Istituto Auxologico Italiano, Milan, Italy.
Cecilia B
CB
Chighizola
Department of Physiology, Favaloro University, Division of Hematology, Thrombosis and Haemostasis, University Hospital, Favaloro Foundation, Buenos Aires, Argentina.
Ricardo
R
Forastiero
Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands.
Philip
P
de Groot
INOVA Diagnostics, San Diego, CA, USA.
Gabriella
G
Lakos
Service de Médecine Interne, Hôpital Claude-Huriez, Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
Marc
M
Lambert
Experimental Laboratory of Immunorheumatology, Istituto Auxologico Italiano, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Italy.
Pierluigi
P
Meroni
Clinical Coagulation Laboratory, Laboratory-Based Research, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Thomas L
TL
Ortel
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michelle
M
Petri
Centre for Rheumatology, Division of Medicine University College London, London, UK.
Anisur
A
Rahman
Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Robert
R
Roubey
Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, London, UK.
Savino
S
Sciascia
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Melissa
M
Snyder
Associated Regional and University Pathologists (ARUP) Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Anne E
AE
Tebo
Department of Clinical and Experimental Sciences, University of Brescia, Italy; Rheumatology and Clinical Immunology Unit, Spedali Civili, Brescia, Italy.
Angela
A
Tincani
Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Rohan
R
Willis
D026683:Advisory Committees; D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D003226:Congresses as Topic; D006801:Humans; D053482:beta 2-Glycoprotein I / Q000276:immunology
D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies; D053482:beta 2-Glycoprotein I
Antiprothrombin antibodies; Domain I; IgA; Lupus anticoagulant; Risk; aCL