Protoaculeine B, a putative N-terminal residue for the novel peptide toxin aculeines.
A new polyamine-modified indole derivative protoaculeine B (1) was isolated from Okinawan marine sponge Axinyssa aculeata. The structure of 1 was assigned on the basis of spectral data along with chemical transformations. Because the structure of 1 greatly inferred the N-terminal amino acid for highly modified peptide toxin aculeines, the probable structure for aculeine B was proposed on the basis of high-resolution mass spectral analysis.
Faculty of Fisheries Sciences and §Creative Research Institution, Hokkaido University , Hakodate 041-8611, Japan.
Satoko
S
Matsunaga
Reimi
R
Kishi
Kazunori
K
Otsuka
Masaki J
MJ
Fujita
Masato
M
Oikawa
Ryuichi
R
Sakai
D000818:Animals; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification; D011073:Polyamines / Q000737:chemistry* / Q000302:isolation & purification; D011161:Porifera / Q000737:chemistry*
D007211:Indoles; D010455:Peptides; D011073:Polyamines; C000591991:protoaculeine B