A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones.
A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy afforded the first practical, one-pot and general approach towards synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual formation of regioisomeric and uncommon isoquinolin-1(4H)-ones.
Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India.
R Gangadhara
RG
Chary
G
G
Dhananjaya
K Vara
KV
Prasad
S
S
Vaishaly
Y S S
YS
Ganesh
Balakrishna
B
Dulla
K Shiva
KS
Kumar
Manojit
M
Pal
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007202:Indicators and Reagents; D007536:Isomerism; D007546:Isoquinolines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy
D007202:Indicators and Reagents; D007546:Isoquinolines; D003300:Copper