Time to re-consider the meaning of BRAF V600E mutation in papillary thyroid carcinoma.
The BRAF V600E mutation, resulting from the BRAFT1799A transversion, is the most common genetic mutation in papillary thyroid carcinoma (PTC), with a mean frequency close to 50% among all cases. A large number of studies in the past decade have tried to dissect the relevance and the function of the V600E mutation in controlling oncogenesis and progression of thyroid cancer. However, several works published in the latest years have provided new evidence, in partial conflict with the previous knowledge, suggesting the need of reconsidering the meaning of the BRAF V600E mutation in PTC. In this work, we attempt to discuss some of the most recent molecular, preclinical and clinical evidence to construct a more exhaustive model of function for the BRAF V600E in development, progression and therapeutic approach of thyroid cancer.
Laboratory of Translational Research, Research and Statistic Infrastructure, Azienda Ospedaliera Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
Greta
G
Gandolfi
Laboratory of Translational Research, Research and Statistic Infrastructure, Azienda Ospedaliera Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
Valentina
V
Sancisi
Pathology Unit, Department of Oncology, Azienda Ospedaliera Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
Simonetta
S
Piana
Laboratory of Translational Research, Research and Statistic Infrastructure, Azienda Ospedaliera Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
Alessia
A
Ciarrocchi
D019943:Amino Acid Substitution; D000818:Animals; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D002291:Carcinoma, Papillary; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000378:metabolism; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*; D014633:Valine / Q000378:metabolism
D005973:Glutamine; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D014633:Valine
BRAF; molecular marker; papillary thyroid carcinoma