Association between coefficients of variation of the R-R intervals on electrocardiograms and post-challenge hyperglycemia in patients with newly diagnosed type 2 diabetes.
The aim of the present study was to examine whether there is a relationship between autonomic function and post-challenge hyperglycemia in patients with type 2 diabetes. Subjects included 122 Japanese patients newly diagnosed with type 2 diabetes. Autonomic nerve function was assessed using coefficients of variation of the R-R intervals on electrocardiograms (CVRR). Unlike anthropometry, insulin secretion and insulin resistance, age (r = -0.209, P < 0.021) and post-challenge plasma glucose at 120 min (PG120; r = -0.219, P < 0.015) were the only variables significantly correlated with CVRR. Age was not significantly correlated with PG120. In multiple regression analyses, CVRR Z-score, but not age, was significantly correlated with PG120. The present results suggest that autonomic function affects post-challenge blood glucose levels independently of age. (J Diabetes Invest,doi: 10.1111/j.2040-1124.2010.00098.x, 2011).
Department of Clinical Laboratory, Kanazawa University Hospital.
Yusuke
Y
Nakade
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science.
Toshinari
T
Takamura
Department of Epidemiology and Public Health, Kanazawa Medical University, Kanazawa, Japan.
Masaru
M
Sakurai
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science.
Hirofumi
H
Misu
Department of Clinical Laboratory, Kanazawa University Hospital.
Mitsuko
M
Nagata
Department of Clinical Laboratory, Kanazawa University Hospital.
Yuko
Y
Nanbu
Department of Clinical Laboratory, Kanazawa University Hospital.
Hiroyasu
H
Oe
Department of Clinical Laboratory, Kanazawa University Hospital.
Toshiji
T
Takamura
Department of Clinical Laboratory, Kanazawa University Hospital.
Yoshio
Y
Sakai
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science.
Shuichi
S
Kaneko
Department of Clinical Laboratory, Kanazawa University Hospital.
Takashi
T
Wada
Autonomic function; Hyperglycemia; Type 2 diabetes mellitus