Cigarette smoking and p300 amplitude in adults: a systematic review.
OBJECTIVE
To determine the association between chronic tobacco cigarette smoking and P300 amplitude.


METHODS
Systematic review with meta-analysis and meta-regression.


METHODS
Medline, Cochrane Database of Systematic Reviews, PsychInfo, and Web of Science.


METHODS
Eligible studies contained P300 amplitudes obtained from either visual or auditory stimuli and standard deviations or errors in female and male subjects older than 18 years in a group of nonabstaining chronic cigarette smokers and a nonsmoking control group.


RESULTS
The 9 eligible studies comprised 13 relevant datasets containing 1,956 current cigarette smokers and 2,194 nonsmoking controls (N = 4,150). The P300 amplitude was smaller in cigarette smokers than in nonsmoking controls (Hedges' g effect size = .365; 95% confidence interval [CI] = 0.196-0.534, p < .001). Meta-regression showed significant positive associations between the number of cigarettes smoked per day at the time of the study (slope estimate = .036, 95% CI = 0.016-0.056, p ≤ .001, length of smoking in years (slope estimate = .056, 95% CI = 0.005-0.102, p = .018), pack years (slope estimate = .018, 95% CI = 0.009-0.031 p = .009), and age (slope estimate = .068, 95% CI = 0.025-0.113, p = .002).


CONCLUSIONS
P300 amplitude was smaller in cigarette smokers than in nonsmoking controls, and a possible dose-response relationship was apparent. Findings indicate a possible association between cigarette smoking and decreased P300 amplitude.
Department of Psychology, Brigham Young University, Provo, UT; Neuroscience Center, Brigham Young University, Provo, UT dawson_hedges@byu.edu.
Dawson
D
Hedges
Neuroscience Center, Brigham Young University, Provo, UT.
David P
DP
Bennett
D000328:Adult; D000367:Age Factors; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult