Gold Catalysed Redox Synthesis of Imidazo[1,2-a]pyridine using PyridineN-Oxide and Alkynes.
A mild, catalytic, atom economical synthesis of imidazo[1,2-a]pyridines has been developed: catalytic PicAuCl2in the presence of an acid produces a range imidazo[1,2-a]pyridines in good yield. This strategy is mild and forseen to be of particular use for the installation of stereogenic centers adjacent to the imidazo[1,2-a]pyridine ring without loss of enantiomeric excess.
Novartis Institute of Biomedical Research, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom ; Department of Chemistry, University of California, Berkeley, California 94720, United States.
Eric P A
EP
Talbot
Novartis Institute of Biomedical Research, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom.
Melodie
M
Richardson
Novartis Institute of Biomedical Research, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom.
Jeffrey M
JM
McKenna
Department of Chemistry, University of California, Berkeley, California 94720, United States.
F Dean
FD
Toste
alkyne; atom economic; gold; imidazo[1,2-a]pyridine; pyridine N-oxide; redox