The many functions of the endoplasmic reticulum chaperones and folding enzymes.
Endoplasmic reticulum (ER) is an essential sub-cellular compartment of the eukaryotic cell performing many diverse functions essential for the cell and the whole organism. ER molecular chaperones and folding enzymes are multidomain proteins that are designed to support nascent proteins entering ER lumen to achieve their native conformation, mediate post-translational modification, prevent misfolded protein aggregation, and facilitate exit from the ER. Typically the role of ER chaperones expands beyond protein folding. Here, we illustrate the multifunctional nature of many ER associated molecular chaperones and folding enzymes and unique functional overlap of these proteins all designed to support the many functions of the ER membrane.
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Laura
L
Halperin
Joanna
J
Jung
Marek
M
Michalak
D000818:Animals; D020013:Calcium Signaling; D003553:Cystine / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000201:enzymology* / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology*; D017510:Protein Folding; D056811:Unfolded Protein Response
D018832:Molecular Chaperones; D003553:Cystine
Endoplasmic reticulum; chaperone; protein folding; protein quality control