Conservation of PHO pathway in ascomycetes and the role of Pho84.
In budding yeast, Saccharomyces cerevisiae, the phosphate signalling and response pathway, known as PHO pathway, monitors phosphate cytoplasmic levels by controlling genes involved in scavenging, uptake and utilization of phosphate. Recent attempts to understand the phosphate starvation response in other ascomycetes have suggested the existence of both common and novel components of the budding yeast PHO pathway in these ascomycetes. In this review, we discuss the components of PHO pathway, their roles in maintaining phosphate homeostasis in yeast and their conservation across ascomycetes. The role of high-affinity transporter, Pho84, in sensing and signalling of phosphate has also been discussed.
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400 005, India.
Parul
P
Tomar
Himanshu
H
Sinha
D001203:Ascomycota / Q000378:metabolism; D001692:Biological Transport; D003593:Cytoplasm / Q000378:metabolism; D008954:Models, Biological; D010710:Phosphates / Q000378:metabolism*; D028081:Proton-Phosphate Symporters / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D015854:Up-Regulation
C105495:PHO84 protein, S cerevisiae; D010710:Phosphates; D028081:Proton-Phosphate Symporters; D029701:Saccharomyces cerevisiae Proteins