Cerebral hypoxia-ischemia causes cardiac damage in a rat model.
Hypoxia-ischemia (HI) is a model of cerebral ischemia used to model neonatal hypoxia and to study brain damage. Interpreting the results of experiments that use HI rests partly on the assumption that only the brain suffers major damage. In this study, we demonstrate that HI also has adverse consequences on the heart. Both infarction scoring and measurements of troponin I indicate cardiac damage subsequent to HI. These results indicate that the effects of HI on the heart may confound the interpretation of experiments that have used HI to study neuroprotection or other aspects of brain damage.
Department of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Oliver
O
Linsell
John C
JC
Ashton
D000818:Animals; D020520:Brain Infarction / Q000150:complications; D004195:Disease Models, Animal; D006331:Heart Diseases / Q000097:blood / Q000209:etiology*; D020925:Hypoxia-Ischemia, Brain / Q000150:complications*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D019210:Troponin I / Q000097:blood
D019210:Troponin I