Quality of life and self-reported lower extremity function in adults with HIV-related distal sensory polyneuropathy.
BACKGROUND
Distal sensory polyneuropathy (DSP) is a common complication of HIV disease. Its effects on quality of life (QOL) and function have not been well described.


OBJECTIVE
The study objectives were: (1) to compare QOL and lower extremity function in people with HIV-related DSP and people with HIV disease who do not have DSP, (2) to determine the extent to which function predicts QOL, (3) to evaluate the agreement of 2 function scales, and (4) to describe the use of pain management resources.


METHODS
This was a cross-sectional survey study with predictive modeling and measurement tool concordant validation.


METHODS
A demographic questionnaire, the Medical Outcomes Study HIV Health Survey, the Lower Extremity Functional Scale (LEFS), the Lower Limb Functional Index (LLFI), and a review of medical records were used. General linear modeling was used to assess group differences in QOL and the relationship between function and QOL. Bland-Altman procedures were used to assess the agreement of the LEFS and the LLFI.


RESULTS
Usable data for analyses were available for 82 of the 94 participants enrolled. The 67% of participants who reported DSP symptoms tended to be older, had HIV disease longer, and were more likely to receive disability benefits. Participants without DSP had better LLFI, LEFS, and physical health summary scores. In multivariate models, lower limb function predicted physical and mental health summary scores. The LLFI identified participants with a lower level of function more often than the LEFS. Participants with DSP were more likely to use medical treatment, physical therapy, and complementary or alternative treatments.


CONCLUSIONS
A sample of convenience was used; the sample size resulted in a low power for the mental health summary score of the Medical Outcomes Study HIV Health Survey.


CONCLUSIONS
Quality of life and function were more impaired in participants with HIV disease and DSP. The LLFI was more likely to capture limitations in function than the LEFS. Participants with DSP reported more frequent use of pain management resources.
M.L.A. Galantino, PT, PhD, MS, MSCE, School of Health Sciences, The Richard Stockton College of New Jersey, 101 Vera King Farris Dr, Office: G-233, Galloway, NJ 08025 (USA), and Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, Pennsylvania. MaryLou.Galantino@stockton.edu.
Mary Lou A
ML
Galantino
D.M. Kietrys, PT, PhD, OCS, Department of Rehabilitation and Movement Sciences, School of Health Related Professions, Rutgers, The State University of New Jersey, Stratford, New Jersey.
David M
DM
Kietrys
J.S. Parrott, PhD, Department of Interdisciplinary Studies, School of Health Related Professions, Rutgers, The State University of New Jersey.
James Scott
JS
Parrott
M.E. Stevens, PT, DPT, Robert Wood Johnson University Hospital Hamilton, Mercerville, New Jersey.
Maureen E
ME
Stevens
A.M. Stevens, RN, BS, Meridian Health-Jersey Shore University Medical Center, Neptune, New Jersey.
Anne Marie
AM
Stevens
D.V. Condoluci, DO, FACOI, Kennedy Health System, Stratford, New Jersey.
David V
DV
Condoluci
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011115:Polyneuropathies / Q000209:etiology* / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D057566:Self Report; D012720:Severity of Illness Index; D055815:Young Adult
D044966:Anti-Retroviral Agents