Acoustic radiation force impulse elastography for non-invasive assessment of disease stage in patients with primary biliary cirrhosis: A preliminary study.
OBJECTIVE
To investigate the diagnostic performance of the acoustic radiation force impulse (ARFI) elastography for the assessment of primary biliary cirrhosis (PBC) stage.


METHODS
Sixty-one patients with PBC in which liver biopsy and ARFI elastography measurements were performed in the same session were included in the study. The diagnostic performance of ARFI elastography for predicting the PBC stage was determined from the area under receiver operating characteristics (AUROC) curve analysis.


RESULTS
ARFI elastography correlated significantly with histological stage (r = 0.74, p < 0.001) in patients with PBC. The AUROC of ARFI elastography for predicting histological stage equal to or higher than II, III, and equal to IV were 0.83, 0.93, and 0.91, respectively. The optimal cut-off values of ARFI elastography were 1.51 m/s, 1.79 m/s, and 2.01 m/s for PBC stage equal to or higher than II, III, and equal to IV, respectively.


CONCLUSIONS
ARFI elastography is an acceptable and powerful technique for quantitative assessment of PBC stage.
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China. Electronic address: zdk002@163.com.
D-K
DK
Zhang
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China.
M
M
Chen
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China.
Y
Y
Liu
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China.
R-F
RF
Wang
Department of Ultrasound, The First Hospital Affiliated to Shanxi Medical University, 030001 Taiyuan, China.
L-P
LP
Liu
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China.
M
M
Li
D001706:Biopsy; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives
C017985:progabide; D005680:gamma-Aminobutyric Acid