Utility of finger maze test for learning and memory abilities in infants of cynomolgus monkeys exposed to thiamazole.
A new type of learning and memory test using a finger maze was conducted in infant cynomolgus monkeys that were exposed to thiamazole (2 and 3.5 mg/kg per day to pregnant animals orally) during the fetal period (gestational days 120 to 150). We modified Tsuchida's original finger maze test method by reducing the number of trials per day and simplifying the criteria for achievement of training, and we added a long-term memory test. In the memory test, thiamazole-exposed infants required greater time to complete the finger maze test than the control infants although no effect was noted in the training or learning test. The results suggest that an impaired long-term memory could be detected by our modified finger maze test.
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL) Ltd., Kagoshima, Japan; Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.
Ayumi
A
Inoue
Akihiro
A
Arima
Hirohito
H
Kato
Shizufumi
S
Ebihara
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008713:Methimazole / Q000008:administration & dosage*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D008713:Methimazole
cynomolgus monkey; finger maze; infant; learning and memory test; thiamazole