Enantioselective organocatalytic partial transfer hydrogenation of lactone-fused quinolines.
The first enantioselective synthesis of 4-aza-podophyllotoxin derivatives by partial transfer hydrogenation of lactone-fused quinolines was achieved using a chiral Brønsted acid catalyst. This reaction was extended to a large scope of substrates with good yields and enantioselectivities.
Université Lille Nord de France , F-59000 Lille, France.
Alexandre
A
Aillerie
Vincent Lemau
VL
de Talancé
Aurélien
A
Moncomble
Till
T
Bousquet
Lydie
L
Pélinski
D002384:Catalysis; D006865:Hydrogenation; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007783:Lactones; D011804:Quinolines