Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men.
Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p < 0.01) with eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.
1Department of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan; 2Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; and 3Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Youngju
Y
Choi
Nobuhiko
N
Akazawa
Asako
A
Zempo-Miyaki
Song-Gyu
SG
Ra
Hitoshi
H
Shiraki
Ryuichi
R
Ajisaka
Seiji
S
Maeda
D000328:Adult; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D055070:Resistance Training / Q000379:methods*; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*; D014664:Vasodilation; D055815:Young Adult