Gluten related disorders.
Gluten associated disorders and the question around these associations has recently attracted attentions of many health professionals. This is because of high prevalence of undiagnosed gluten related disorders presenting with a multitude of symptoms and complications inside and outside small bowel. While the environmental factors associated with a complex genetics are leading to destructions of the small intestinal villi resulting in malabsorption syndrome in CD, GS is characterised by negative antibodies and grossly normal histology. The association between celiac disease and other disorders has been clearly established and there have been many reports of numerous intestinal and extra intestinal coexistent disorders with CD. But there is little information available regarding the clinical behavior of gluten sensitivity. In this review we discuss the clinical presentation of non-celiac GS and the prospect of current and the future diagnostic pathway.
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Mohammad
M
Rostami Nejad
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Maryam
M
Karkhane
Mashhad University of Medical Sciences, School of Pharmacy, Biotechnology Department, Mashhad, Iran.
Abdolrazagh
A
Marzban
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Ehsan
E
Nazemalhosseini Mojarad
School of Medicine, University of Birmingham, UK.
Kamran
K
Rostami
Celiac disease; Differentiation; Gluten sensitivity; Histology