Divergent picobirnaviruses in human feces.
The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest of ORF2.
terryfeifan@gmail.com delwarte@medicine.ucsf.edu.
Terry Fei Fan
http://orcid.org/0000-0002-4815-8697
TF
Ng
National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Everardo
E
Vega
Blood Systems Research Institute, San Francisco, California, USA.
Nikola O
NO
Kondov
Blood Systems Research Institute, San Francisco, California, USA.
Christopher
C
Markey
Xutao
X
Deng
National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Nicole
N
Gregoricus
National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jan
J
Vinjé
terryfeifan@gmail.com delwarte@medicine.ucsf.edu.
Eric
E
Delwart