Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions.
Scavenger receptor class B type I (SR-BI), is a physiologically relevant HDL receptor that mediates selective uptake of lipoprotein (HDL)-derived cholesteryl ester (CE) in vitro and in vivo. Mammalian SR-BI is a 509-amino acid, ~82 kDa glycoprotein that contains N- and C-terminal cytoplasmic domains, two-transmembrane domains, as well as a large extracellular domain containing 5-6 cysteine residues and multiple sites for N-linked glycosylation. The size and structural characteristics of SR-BI, however, vary considerably among lower vertebrates and insects. Recently, significant progress has been made in understanding the molecular mechanisms involved in the posttranscriptional/posttranslational regulation of SR-BI in a tissue specific manner. The purpose of this review is to summarize the current body of knowledge about the events and molecules connected with the posttranscriptional/posttranslational regulation of SR-BI and to update the molecular and functional characteristics of the insect SR-BI orthologs.
Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304; Division of Endocrinology, Stanford University, Stanford, California 94305.
Wen-Jun
WJ
Shen
Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304.
Jie
J
Hu
Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304; Division of Endocrinology, Stanford University, Stanford, California 94305.
Zhigang
Z
Hu
Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304; Division of Endocrinology, Stanford University, Stanford, California 94305.
Fredric B
FB
Kraemer
Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304; Division of Gastroenterology and Hepatology, Stanford University, Stanford, California 94305. Electronic address: salman.azhar@va.gov.
Salman
S
Azhar
D000818:Animals; D001692:Biological Transport; D005786:Gene Expression Regulation; D006031:Glycosylation; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009928:Organ Specificity; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D018110:Receptors, Lipoprotein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051122:Scavenger Receptors, Class B / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity
D019476:Insect Proteins; D008075:Lipoproteins, HDL; D018110:Receptors, Lipoprotein; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; C031616:high density lipoprotein receptors
HDL receptor; Selective uptake; Steroid hormones