Clinical and pathological features of acute kidney injury in children.
OBJECTIVE
Based on the diagnostic and staging criteria of acute kidney injury (AKI), we analyze the clinical and pathological characteristics of children at different stages of AKI and explored their clinical significances.


METHODS
165 children with AKI were divided into stage 1, stage 2, and stage 3 groups. Clinical and pathologic characteristics of AKI children were analyzed.


RESULTS
The three groups of patients showed significant differences in age, etiology, pathological damage, and the median recovery time of serum creatinine. Of the 165 patients, the incidence and duration of hematuria showed significant differences among the three groups, and the stage 1 group showed longer duration of proteinuria.


CONCLUSIONS
The patients were largely in stage 1 and 3. The children with AKI in stage 1 were largely school-age children and acute glomerulonephritis (AGN) was the main etiology. The AKI children in stage 3 were mainly infants, of which the etiology was mainly drugs and septicemia. The pathological type was mainly acute tubulointerstitial nephritis, and the renal function recovery was slow.
Academy of Pediatrics of University of South China , Changsha, Hunan , People's Republic of China and.
Zhihui
Z
Li
Zhijuan
Z
Kang
Cuirong
C
Duan
Tianhui
T
Wu
Liang
L
Zhang
Mai
M
Xun
Yunfeng
Y
Ding
Yi
Y
Zhang
Yan
Y
Yin
D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology; D012189:Retrospective Studies; D012720:Severity of Illness Index
D003404:Creatinine
Acute kidney injury; children; clinical feature; pathology; prognosis