Trace amines and cocaine abuse.
Cocaine addiction remains a clinical challenge with no effective pharmacotherapy available. Trace amine associated receptor (TAAR) 1 represents a promising drug target for the modulation of dopaminergic system and stimulant abuse. This Viewpoint discusses the emerging data which strongly suggest that TAAR 1 functions as a molecular "brake" that controls the addiction-related effects of cocaine and could be a novel drug target for the development of efficacious pharmacotherapy to treat cocaine addiction.
Department of Pharmacology and Toxicology, University at Buffalo , Buffalo, New York 14214, United States.
Jun-Xu
JX
Li
D000588:Amines / Q000378:metabolism; D000818:Animals; D002491:Central Nervous System Agents / Q000737:chemistry / Q000627:therapeutic use; D019970:Cocaine-Related Disorders / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000378:metabolism*; D000095383:Trace Amine-Associated Receptors
D000588:Amines; D002491:Central Nervous System Agents; D043562:Receptors, G-Protein-Coupled; D000095383:Trace Amine-Associated Receptors