Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.
Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. erikahenriques07@yahoo.com.br.
Erika Maria Henriques
EM
Monteiro
Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. lucano.farm@gmail.com.
Lucas Apolinário
LA
Chibli
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. hytomani@yahoo.com.
Célia Hitomi
CH
Yamamoto
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. miriamaop@yahoo.com.br.
Mônica Cecília Santana
MC
Pereira
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. fernandampvilela@gmail.com.
Fernanda Maria Pinto
FM
Vilela
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. mirianpereira.rodarte@ufjf.edu.br.
Mírian Pereira
MP
Rodarte
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. miriamaop@yahoo.com.br.
Míriam Aparecida de Oliveira
MA
Pinto
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. penhaufjf1@yahoo.com.br.
Maria da Penha Henriques
Mda P
do Amaral
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. marcelosilverio@hotmail.com.
Marcelo Silva
MS
Silvério
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. ailson.luz@ufjf.edu.br.
Ana Lúcia Santos de Matos
AL
Araújo
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. ailson.luz@ufjf.edu.br.
Aílson da Luz André
Ada L
de Araújo
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. glauciemar@gmail.com.
Glauciemar
G
Del-Vechio-Vieira
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. orlando.sousa@ufjf.edu.br.
Orlando Vieira
OV
de Sousa
D019342:Acetic Acid / Q000008:administration & dosage / Q000009:adverse effects; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000008:administration & dosage / Q000009:adverse effects; D004149:Dioxoles / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005557:Formaldehyde / Q000008:administration & dosage / Q000009:adverse effects; D007249:Inflammation / Q000188:drug therapy; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D051379:Mice; D059225:Nociception / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D012715:Sesame Oil / Q000494:pharmacology*; D023382:Toxicity Tests, Acute
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004149:Dioxoles; D017705:Lignans; D005557:Formaldehyde; D012715:Sesame Oil; D002351:Carrageenan; D019342:Acetic Acid; C054125:sesamin