Pathophysiology of ischemic placental disease.
The pregnancy disorders associated with placental ischemia share many similar pathological and pathophysiological features and are associated with the failure to deliver adequate nutrients and oxygen to the placenta. The origins of this deficiency are a subject of intense study. In this article, I review the genesis and consequences of this pathology addressing the similarities and the differences with the different disorders and addressing current gaps in our knowledge.
Magee-Womens Research Institute, Pittsburgh, PA 15213; Department of Obstetrics, Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research, University of Pittsburgh, Pittsburgh, PA. Electronic address: jroberts@mwri.magee.edu.
James M
JM
Roberts
D000037:Abruptio Placentae / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D059865:Endoplasmic Reticulum Stress; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D007511:Ischemia / Q000453:epidemiology / Q000503:physiopathology*; D018384:Oxidative Stress; D010920:Placenta / Q000098:blood supply*; D010922:Placenta Diseases / Q000453:epidemiology / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors
intrauterine growth restriction; placenta; placenta ischemia; preeclampsia; premature birth