Antibody-specific behavioral effects: intracerebroventricular injection of antiphospholipid antibodies induces hyperactive behavior while anti-ribosomal-P antibodies induces depression and smell deficits in mice.
This study compares the effects of human antiphospholipid (aPL) and anti-P-ribosomal (anti-P) IgG and control IgG on the brain. Intracerebroventricular (ICV) injected aPL mice (exAPS) displayed specific hyperactivity compared to anti-P-injected (exSLE) and control mice. In contrast ICV injected anti-P-injected mice specifically displayed depression-like behavior and olfactory impairment compared to the other 2 groups. Both anti-P and aPL injected mice were impaired in the passive avoidance test compared to controls. The distinct cognitive effects of the 2 pathogenic antibodies argue for a specific and differential direct action of these autoantibodies on the brain in clinical disease.
Department of Neurology, Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Israel. Electronic address: avivakatzav@gmail.com.
Aviva
A
Katzav
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Israel.
Tal
T
Ben-Ziv
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Israel.
Miri
M
Blank
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
Chaim G
CG
Pick
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Israel; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmunity Diseases, Tel Aviv University, Israel.
Yehuda
Y
Shoenfeld
Department of Neurology, Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Israel.
Joab
J
Chapman
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000633:toxicity*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000276:immunology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003863:Depression / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced* / Q000276:immunology; D007074:Immunoglobulin G / Q000633:toxicity*; D007276:Injections, Intraventricular; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D000857:Olfaction Disorders / Q000139:chemically induced* / Q000276:immunology; D011597:Psychomotor Performance / Q000187:drug effects; D012269:Ribosomal Proteins / Q000276:immunology*; D012684:Sensory Thresholds / Q000187:drug effects; D012903:Smell / Q000187:drug effects / Q000276:immunology
D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D012269:Ribosomal Proteins
Autoantibodies; Behavior; Cognitive function; Depression; Experimental mouse model; Smell