Association of TLR4 and TLR5 gene polymorphisms with Graves' disease in Chinese Cantonese population.
Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of TLR4 and TLR5 gene polymorphisms with GD in Chinese Cantonese population. Four single nucleotide polymorphisms (SNPs), rs11536889 and rs7873784 in TLR4, rs2072493 and rs5744174 in TLR5, were evaluated in 332 GD patients and 351 unrelated controls from Chinese Cantonese population. The minor allele C of TLR5 rs5744174 decreased the risk to GD in females (ORC vs. T=0.63; p=0.003; ptrend=0.003). Under a dominant model, rs5744174 conferred a protective effect in all cases (ORCC/CT vs. TT=0.65; p=0.009) or female subset (ORCC/CT vs. TT=0.57; p=0.002). Under a co-dominant model, rs5744174 also conferred a protective effect in all cases (ORTC vs. TT=0.64; p=0.008) and females (ORTC vs. TT=0.57; p=0.002). The haplotype A-C of TLR5 (rs2072493-rs5744174) decreased the risk of GD in females (OR=0.62; p=0.002). The other three SNPs were not found associated with GD. This study provided evidence that polymorphisms in TLR5 might be associated with decreased susceptibility of GD in females.
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.
WenJuan
W
Xiao
Shenzhen People's Hospital (The Second Affiliated Hospital of Jinan University), Shenzhen 518020, PR China.
ZeLin
Z
Liu
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.
JiangHai
J
Lin
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.
ChunJiang
C
Xiong
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.
JingBo
J
Li
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.
KeJing
K
Wu
Shenzhen People's Hospital (The Second Affiliated Hospital of Jinan University), Shenzhen 518020, PR China.
Yun
Y
Ma
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China.
YingXue
Y
Gong
Research Center for Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China. Electronic address: zhliu@jnu.edu.cn.
ZeHuan
Z
Liu
D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D051198:Toll-Like Receptor 5 / Q000235:genetics*
C495345:TLR4 protein, human; C495346:TLR5 protein, human; D051197:Toll-Like Receptor 4; D051198:Toll-Like Receptor 5
Association; Graves’ disease; Polymorphisms; Toll like receptor