Chronic sleep curtailment and adiposity.
OBJECTIVE
To examine the extent to which chronic sleep curtailment from infancy to mid-childhood is associated with total and central adiposity.


METHODS
We studied 1046 children participating in a prospective cohort study. At age 6 months and yearly from age 1 to 7 years, mothers reported their children's sleep duration in a usual 24-hour period. The main exposure was a sleep curtailment score from age 6 months to 7 years. The range of the total score was 0 to 13, where 0 indicated the maximal sleep curtailment and 13 indicated never having curtailed sleep. Outcomes in mid-childhood were BMI z score, dual X-ray absorptiometry total and trunk fat mass index (kg/m(2)), and waist and hip circumferences (cm).


RESULTS
The mean (SD) sleep score was 10.2 (2.7); 4.4% scored a 0 to 4, indicating multiple exposures to sleep curtailment between age 6 months to 7 years, 12.3% scored 5 to 7, 14.1% scored 8 to 9, 28.8% scored 10 to 11, and 40.3% scored 12 to 13. In multivariable models, children who had a sleep score of 0 to 4 had a BMI z score that was 0.48 U (95% confidence interval, 0.13 to 0.83) higher than those who had a sleep score of 12 to 13. We observed similar associations of higher total and trunk fat mass index and waist and hip circumferences, and higher odds of obesity (odds ratio, 2.62; 95% confidence interval, 0.99 to 6.97) among children who had a score of 0 to 4 vs 12 to 13.


CONCLUSIONS
Chronic sleep curtailment from infancy to school age was associated with higher overall and central adiposity in mid-childhood.
Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachussetts;Department of Nutrition, Harvard School of Public Health, Boston, Massachussetts; and etaveras@partners.org.
Elsie M
EM
Taveras
Department of Nutrition, Harvard School of Public Health, Boston, Massachussetts; andObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachussetts;
Matthew W
MW
Gillman
Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachussetts;
Michelle-Marie
MM
Peña
Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachussetts.
Susan
S
Redline
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachussetts;
Sheryl L
SL
Rifas-Shiman
D000367:Age Factors; D000886:Anthropometry; D050218:Body Fat Distribution; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D056128:Obesity, Abdominal / Q000453:epidemiology* / Q000209:etiology*; D016017:Odds Ratio; D063766:Pediatric Obesity / Q000453:epidemiology* / Q000209:etiology*; D011446:Prospective Studies; D012892:Sleep Deprivation / Q000150:complications* / Q000453:epidemiology*; D013223:Statistics as Topic
BMI; adiposity; early childhood; fat mass index; obesity; sleep curtailment