High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men.
High cardiorespiratory fitness (CRF) is associated with a reduced risk of Type 2 diabetes mellitus (T2DM) and improved β-cell function; genetic factors also determine these risks. This cross-sectional study investigated whether CRF modifies the association of polygenic risk of T2DM with glucose metabolism in nondiabetic Japanese men. Fasting plasma glucose, insulin, and glycated hemoglobin (HbA1c) levels were measured in 174 Japanese men (age: 20-79 yr). β-Cell function and insulin resistance were evaluated by calculating HOMA-β and HOMA-IR, respectively. CRF was assessed by measuring maximal oxygen uptake (V̇o2max). Subjects were divided into the low and high CRF groups within each age group according to the median V̇o2max. Eleven single nucleotide polymorphisms (SNPs) associated with T2DM were analyzed and used to calculate genetic risk score (GRS); subjects were divided into the low, middle, and high GRS groups. The high GRS group had higher HbA1c levels than the low GRS group in both the low and high CRF groups (P < 0.05). Furthermore, the individuals with a high GRS had a lower HOMA-β than those with a low GRS regardless of CRF (P < 0.05). In multiple linear regression analysis, although GRS was a significant predictor of HbA1c (β = 0.153, P = 0.025), V̇o2max was also associated with HbA1c (β = -0.240, P = 0.041) independent of GRS. These results suggest that CRF is associated with HbA1c levels independent of GRS derived from T2DM-related SNPs; however, it does not modify the association of GRS with increased HbA1c or impaired β-cell function.
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, Japan;
Kumpei
K
Tanisawa
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
Tomoko
T
Ito
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
Xiaomin
X
Sun
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
Ryuken
R
Ise
Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and.
Satomi
S
Oshima
Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and.
Zhen-Bo
ZB
Cao
Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, Saitama, Japan.
Shizuo
S
Sakamoto
Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, Japan;
Masashi
M
Tanaka
Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, Saitama, Japan mhiguchi@waseda.jp.
Mitsuru
M
Higuchi
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000235:genetics / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012306:Risk; D012307:Risk Factors; D055815:Young Adult
D001786:Blood Glucose; D005947:Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human
HbA1c; cardiorespiratory fitness; polygenic risk; β-cell function