MicroRNA expression altered by diet: can food be medicinal?
As the link between metabolism and major disease processes becomes more well-defined, the identification of key molecular targets is leading to new therapeutic strategies. As a result, small non-coding RNA molecules that regulate gene expression via epigenetic alterations, microRNAs have been identified as regulators of these metabolic processes. In the last decade, dietary interventions have been used to change metabolism and to potentially alter disease progression and clinical outcomes. These interventions have been linked, at a molecular level, to microRNAs. This review will summarize the role of various dietary strategies on the expression of several microRNA families.
Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, United States.
Joshua D
JD
Palmer
Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, United States.
Benjamin P
BP
Soule
Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, United States.
Brittany A
BA
Simone
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, United States.
Nicholas G
NG
Zaorsky
Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, United States.
Lianjin
L
Jin
Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, United States. Electronic address: nicole.simone@jeffersonhospital.org.
Nicole L
NL
Simone
D015415:Biomarkers / Q000378:metabolism; D004032:Diet; D005502:Food; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D010946:Plants, Medicinal
D015415:Biomarkers; D035683:MicroRNAs
Aging; Cancer; Diet; Nutrition; miR; microRNA