Buprenorphine and methadone for opioid addiction during pregnancy.
Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use. As part of a comprehensive care plan, such therapy may result in improved access to prenatal care, reduced illicit drug use, reduced exposure to infections associated with intravenous drug use, and improved maternal nutrition and infant birth weight. This article describes differences in patient selection between the two drugs, their relative safety during pregnancy, and changes in daily doses as a guide for prescribing clinicians.
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC 10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: emozurkewich@salud.unm.edu.
Ellen L
EL
Mozurkewich
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC 10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA.
William F
WF
Rayburn
D000701:Analgesics, Opioid / Q000009:adverse effects*; D002047:Buprenorphine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008691:Methadone / Q000627:therapeutic use*; D009357:Neonatal Abstinence Syndrome / Q000188:drug therapy / Q000517:prevention & control*; D058850:Opiate Substitution Treatment / Q000379:methods*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000523:psychology*; D037841:Pregnant People / Q000523:psychology; D011297:Prenatal Exposure Delayed Effects; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D002047:Buprenorphine; D008691:Methadone
Abstinence; Buprenorphine; Methadone; Neonatal; Pregnancy opioid addiction