Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity.
Lipasin (also known as C19ORF80, RIFL, ANGPTL8 and betatrophin) is a newly discovered circulating factor that regulates lipid metabolism and promotes pancreatic β-cell proliferation. Whether circulating levels of lipasin in humans are altered in a) type 2 diabetes; b) obesity and c) the postprandial state, however, is unknown. The current study aimed to compare serum lipasin levels in those who were a) non-diabetic (N=15) or diabetic (BMI- and age-matched; N=14); b) lean or obese (N=53 totally) and c) fasting and 2 hours following a defined meal (N=12). Serum lipasin levels were determined by the enzyme-linked immunosorbent assay. Lipasin levels [mean±SEM] were increased by more than two fold (P<0.001) in the diabetic patients (5.56±0.73 ng/mL) as compared to the control subjects (2.19±0.24 ng/mL). Serum lipasin levels were positively correlated with BMI (rho=0.49, P<0.001), and showed a 35% increase 2 hours following a defined meal (P=0.009). Therefore, lipasin/betatrophin is nutritionally-regulated hepatokine that is increased in human type 2 diabetes and obesity.
1] Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA [2].
Zhiyao
Z
Fu
1] Division of Endocrinology, School of Medicine, Wayne State University, Detroit, MI 48201, USA [2].
Feven
F
Berhane
Division of Endocrinology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Alemu
A
Fite
Division of Endocrinology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Berhane
B
Seyoum
1] Division of Endocrinology, School of Medicine, Wayne State University, Detroit, MI 48201, USA [2] Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
Abdul B
AB
Abou-Samra
1] Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA [2] Division of Endocrinology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Ren
R
Zhang
D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis*; D036361:Peptide Hormones / Q000097:blood*; D011379:Prognosis
C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers; D036361:Peptide Hormones