Chronic Neutrophilic Leukemia with V617F JAK2 Mutation.
Chronic neutrophilic leukemia (CNL) is a rare disease grouped under World health organization classification as chronic myeloproliferative disease. It is a diagnosis of exclusion in patients with sustained mature neutrophilia and splenomegaly with no evidence of other myeloproliferative disease or reactive neutrophilia. V617F JAK 2 mutation has been described in classical myeloproliferative diseases, but its association with CNL has been reported in a few cases. Here in, we describe three cases of CNL with presence of V617F JAK 2 mutation. To distinguish CNL from secondary neutrophilia can be difficult. Detection of the V617F JAK 2 mutation in such scenario can provide a useful diagnostic test to establish the neoplastic nature of the neutrophilia.
Laboratory Oncology Unit, Dr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, 110029 India.
Smeeta
S
Gajendra
Laboratory Oncology Unit, Dr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, 110029 India.
Ritu
R
Gupta
Laboratory Oncology Unit, Dr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, 110029 India.
Meenal
M
Chandgothia
Department of Medical Oncology, DR. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India.
Lalit
L
Kumar
Laboratory Oncology Unit, Dr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, 110029 India.
Richa
R
Gupta
Acton Biotech (I) Pvt. Ltd, Pune, India.
Snehal Motilal
SM
Chavan
Chronic myeloproliferative disease; Chronic neutrophilic leukemia; V617F JAK 2 mutation