Stem cell responses to nanotopography.
Cells interact with various nanoscaled topographical and biochemical cues in their cellular macromolecular environment. Nanotopography recreates or mimic the cellular macromolecular environment in vitro. The influence of material surface topography on the behavior of adherent cells has been studied. Current techniques enable various kinds of nanopatterned surface to be generated and applied to cells. The purpose of this review is to provide an overview of nanotopography and its surface patterns, and introduce nanotopography effects on cell behavior including cell attachment, proliferation, and cell differentiation with particular emphasis on musculoskeletal regeneration.
Department of Orthopaedics, Dongguk University, Ilsan Hospital, Korea.
Siyeon
S
Park
Gun-Il
GI
Im
D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
musculoskeletal regeneration; nanotopography; stem cells