Orthopaedic implant failure: aseptic implant loosening--the contribution and future challenges of mouse models in translational research.
Aseptic loosening as a result of wear debris is considered to be the main cause of long-term implant failure in orthopaedic surgery and improved biomaterials for bearing surfaces decreases significantly the release of micrometric wear particles. Increasingly, in-depth knowledge of osteoimmunology highlights the role of nanoparticles and ions released from some of these new bearing couples, opening up a new era in the comprehension of aseptic loosening. Mouse models have been essential in the progress made in the early comprehension of pathophysiology and in testing new therapeutic agents for particle-induced osteolysis. However, despite this encouraging progress, there is still no valid clinical alternative to revision surgery. The present review provides an update of the most commonly used bearing couples, the current concepts regarding particle-cell interactions and the approaches used to study the biology of periprosthetic osteolysis. It also discusses the contribution and future challenges of mouse models for successful translation of the preclinical progress into clinical applications.
Luis Alberto
LA
Cordova
Verena
V
Stresing
Bérengère
B
Gobin
Philippe
P
Rosset
Norbert
N
Passuti
François
F
Gouin
Valérie
V
Trichet
Pierre
P
Layrolle
Dominique
D
Heymann
D000818:Animals; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D001696:Biomechanical Phenomena; D002516:Ceramics / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004868:Equipment Failure; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects; D010014:Osteolysis / Q000209:etiology* / Q000503:physiopathology; D010316:Particle Size; D011095:Polyethylenes / Q000009:adverse effects / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000009:adverse effects; D012086:Reoperation; D057170:Translational Research, Biomedical
D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D019904:Polymethyl Methacrylate