Papillary ependymoma of the endometrium.
OBJECTIVE
To report an exceptional case of papillary ependymoma occurring in the endometrium.


RESULTS
A clinicopathological study was performed regarding a case of papillary ependymoma occurring in the endometrial cavity of a 61-year-old patient who had presented with a solid-type, stage III anaplastic ependymoma of the ovary, treated with cytoreductive surgery that included total abdominal hysterectomy. The uterus was enlarged and showed a dilated cavity, with broadly implanted papillary excrescences without myometrial invasion that were covered by tall, cylindrical cells. These cells had glial fibrillary acidic protein-expressing cytoplasm that was also positive for cytokeratins 7, 8, 18, and 34β-E12, epithelial membrane antigen, S100 protein, vimentin, and oestrogen and progesterone receptors.


CONCLUSIONS
Pathogenetically, the presence of this uterine ependymoma could represent either an example of multicentricity or a phenomenon of transtubal implantation of the ovarian tumour. Exceptionally, papillary ependymoma can occur in the endometrium, and may prompt differential diagnoses with other papillary endometrial tumours. Pathologists should consider this rare possibility in the differential diagnosis of papillary ovarian and endometrial lesions.
Departments of Pathology, San Cecilio University Hospital, University of Granada, Granada, Spain.
Maolly
M
Schuldt
Juan A
JA
Retamero
Christine
C
Bergeron
Francisco F
FF
Nogales
D016889:Endometrial Neoplasms / Q000473:pathology*; D004806:Ependymoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery
central nervous system tumours; ependymoma; glial fibrillary acidic protein; uterus