Next generation platforms for high-throughput biodosimetry.
Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems.
Center for High-Throughput Minimally Invasive Radiation Biodosimetry, Columbia University Medical Center, New York, NY 10032, USA mr3209@columbia.edu.
Mikhail
M
Repin
Center for High-Throughput Minimally Invasive Radiation Biodosimetry, Columbia University Medical Center, New York, NY 10032, USA.
Helen C
HC
Turner
Center for High-Throughput Minimally Invasive Radiation Biodosimetry, Columbia University Medical Center, New York, NY 10032, USA.
Guy
G
Garty
Center for High-Throughput Minimally Invasive Radiation Biodosimetry, Columbia University Medical Center, New York, NY 10032, USA.
David J
DJ
Brenner
D057205:Automation, Laboratory; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002877:Chromosomes, Human / Q000528:radiation effects*; D019411:Clinical Laboratory Techniques / Q000295:instrumentation* / Q000379:methods; D020732:Cytogenetic Analysis / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D057166:High-Throughput Screening Assays / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008677:Metaphase / Q000528:radiation effects; D011834:Radiation Monitoring / Q000379:methods*