Change in growth differentiation factor 15, but not C-reactive protein, independently predicts major cardiac events in patients with non-ST elevation acute coronary syndrome.
Among the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk. The concentrations of inflammatory biomarkers, however, are influenced, among others, by physiological variations, which are the natural, within-individual variation occurring over time. The aims of our study are: (a) to describe the changes in hsCRP and GDF-15 levels over a period of time and after an episode of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and (b) to examine whether the rate of change in hsCRP and GDF-15 after the acute event is associated with long-term major cardiovascular adverse events (MACE). Two hundred and Fifty five NSTE-ACS patients were included in the study. We measured hsCRP and GDF-15 concentrations, at admission and again 36 months after admission (end of the follow-up period). The present study shows that the change of hsCRP levels, measured after 36 months, does not predict MACE in NSTEACS-patients. However, the level of GDF-15 measured, after 36 months, was a stronger predictor of MACE, in comparison to the acute unstable phase.
Department of Cardiology, Hospital Universitario de Canarias, Ofra s/n La Cuesta, 38320 Tenerife, Spain ; Instituto Universitario de Tecnología Biomédicas, Ofra s/n La Cuesta, 38320 Tenerife, Spain.
Alberto
0000-0002-6384-6893
A
Dominguez-Rodriguez
Instituto Universitario de Tecnología Biomédicas, Ofra s/n La Cuesta, 38320 Tenerife, Spain ; Department of Physiology, University of La Laguna, Ofra s/n La Cuesta, 38320 Tenerife, Spain.
Pedro
0000-0002-7553-1784
P
Abreu-Gonzalez
Department of Cardiology, Hospital Universitario de Canarias, Ofra s/n La Cuesta, 38320 Tenerife, Spain.
Idaira F
IF
Hernandez-Baldomero
Hospital Universitario Central de Asturias, Area del Corazón, 33006 Oviedo, Spain.
Pablo
0000-0002-4958-6108
P
Avanzas
Department of Cardiology, Hospital Universitario de Canarias, Ofra s/n La Cuesta, 38320 Tenerife, Spain.
Francisco
F
Bosa-Ojeda
D054058:Acute Coronary Syndrome / Q000235:genetics / Q000378:metabolism*; D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
D015415:Biomarkers; D055436:Growth Differentiation Factor 15; D002097:C-Reactive Protein