Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
BACKGROUND
Management of clinically negative lymph nodes (cN0) in primary lip squamous cell carcinoma (SCC) has always been a controversial topic.


METHODS
A systematic review of English-language electronic databases using Medline, Embase, Cochrane library, Google Scholar, SCI, and specific journals on the subject matter was done. Only the studies mentioning primary nonmetastatic lip SCC with cN0 neck treated by surgery only and having at least 2 years of follow-up data were selected. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analysis was followed.


RESULTS
The pooled estimate of occult metastasis in neck dissected specimen was 0.17 (95% confidence interval [CI], 0.10-0.28) and that of delayed nodal metastasis in patients without neck dissection was 0.08 (95% CI, 0.01-0.18).


CONCLUSIONS
The results do not prove sufficient to justify elective treatment of the neck in primary cN0 lip SCC and close observation would be a viable option in such cases. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1392-1400, 2015.
Department of Oral and Maxillofacial Surgery, 2nd Affiliated Hospital of Jiamusi University, Jiamusi City, Heilongjiang, People's Republic of China.
Kishor
K
Bhandari
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Haidian District, Beijing, People's Republic of China.
Dian-can
DC
Wang
Department of Oral and Maxillofacial Surgery, 2nd Affiliated Hospital of Jiamusi University, Jiamusi City, Heilongjiang, People's Republic of China.
Shan-chang
SC
Li
Department of Oral and Maxillofacial Surgery, 2nd Affiliated Hospital of Jiamusi University, Jiamusi City, Heilongjiang, People's Republic of China.
Bing-hua
BH
Jiang
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Haidian District, Beijing, People's Republic of China.
Yu-xing
YX
Guo
Department of Oral and Maxillofacial Surgery, 2nd Affiliated Hospital of Jiamusi University, Jiamusi City, Heilongjiang, People's Republic of China.
Ujjwal
U
Koirala
Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital of Jiamusi University, Jiamusi City, Heilongjiang, People's Republic of China.
Xiao-yan
XY
Du
D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D018572:Disease-Free Survival; D017558:Elective Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D008048:Lip Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008297:Male; D037981:Neck Dissection / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
clinically node-negative (cN0) neck; elective neck dissection; lip squamous cell carcinoma; lymphatic metastasis; surgery