Adult-Onset Asthma Associated With Simultaneous Conjunctival, Eyelid, and Orbital Xanthogranulomatosis Responsive to Systemic Immunosuppression.
Adult xanthogranulomatous disease involving the ocular or orbital tissues is rare. The authors present a 63-year-old asthmatic woman with progressive left eyelid ptosis and fatigue in whom this diagnosis was clinically suspected on the basis of the characteristic waxy indurated yellow periocular and conjunctival lesions. These findings prompted an incisional biopsy which found evidence of Touton giant cells, necessitating a systemic evaluation which excluded the presence of hematological abnormalities or malignancy. The simultaneous occurrence of conjunctival, eyelid, and orbital xanthogranulomas has not been previously described in adult-onset asthma and periocular xanthogranuloma. The lesions were responsive to long-term systemic immunosuppression.
*Department of Ophthalmology and Visual Sciences, Vancouver Hospital Eye Care Centre and University of British Columbia; and †Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada.
Pari N
PN
Shams
Steve L
SL
Rasmussen
Peter J
PJ
Dolman
D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003229:Conjunctival Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005141:Eyelid Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006099:Granuloma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009916:Orbital Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D014973:Xanthomatosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D005938:Glucocorticoids; D011241:Prednisone