Mn(II)-containing coordination nanoparticles as highly efficient T(1) contrast agents for magnetic resonance imaging.
Large longitudinal relaxivities were observed in Mn(II)-containing Prussian blue analogue nanoparticles. At low concentrations and high field (7 T), a remarkable positive contrast enhancement was seen which exceeded that of clinical contrast agents and was attributed to the very large proportion of surface atoms of these coordination nanoparticles.
Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS, Université Paris 11, 91405 Orsay, France. laure.catala@u-psud.fr.
Gabriella
G
Paul
Yoann
Y
Prado
Nada
N
Dia
Eric
E
Rivière
Sophie
S
Laurent
Mathieu
M
Roch
Luce Vander
LV
Elst
Robert N
RN
Muller
Lucie
L
Sancey
Pascal
P
Perriat
Olivier
O
Tillement
Talal
T
Mallah
Laure
L
Catala
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D003287:Contrast Media / Q000138:chemical synthesis*; D004354:Drug Screening Assays, Antitumor; D005295:Ferrocyanides / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry* / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry*; D045663:Quantum Dots
D000970:Antineoplastic Agents; D003287:Contrast Media; D005295:Ferrocyanides; D017895:Manganese Compounds; C000170:ferric ferrocyanide