Rh(III)-catalyzed cascade oxidative olefination/cyclization of picolinamides and alkenes via C-H activation.
Rh(III)-catalyzed cascade oxidative alkenylation/cyclization of picolinamides and alkenes to furnish pyrido pyrrolone derivatives is described, in which three C-H bonds and one N-H bond broke, while one C-C bond and one C-N bond formed. The reaction proceeded with high yield and high regioselectivity and stereoselectivity. Moreover, copper acetate can also be used in catalytic amounts with O2 serving as the terminal oxidant.
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
Shangjun
S
Cai
Chao
C
Chen
Peng
P
Shao
Chanjuan
C
Xi
D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010848:Picolinic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D012238:Rhodium; D013237:Stereoisomerism
D000475:Alkenes; D000577:Amides; D010848:Picolinic Acids; D012238:Rhodium; C003142:picolinamide