Effects of tracer arrival time on the accuracy of high-resolution (voxel-wise) myocardial perfusion maps from contrast-enhanced first-pass perfusion magnetic resonance.
First-pass perfusion cardiac magnetic resonance(CMR) allows the quantitative assessment of myocardial blood flow(MBF). However, flow estimates are sensitive to the delay between the arterial and myocardial tissue tracer arrival time (tOnset) and the accurate estimation of MBF relies on the precise identification of tOnset . The aim of this study is to assess the sensitivity of the quantification process to tOnset at voxel level. Perfusion data were obtained from series of simulated data, a hardware perfusion phantom, and patients. Fermi deconvolution has been used for analysis. A novel algorithm, based on sequential deconvolution,which minimizes the error between myocardial curves and fitted curves obtained after deconvolution, has been used to identify the optimal tOnset for each region. Voxel-wise analysis showed to be more sensitive to tOnset compared to segmental analysis. The automated detection of the tOnset allowed a net improvement of the accuracy of MBF quantification and in patients the identification of perfusion abnormalities in territories that were missed when a constant user-selected tOnset was used. Our results indicate that high-resolution MBF quantification should be performed with optimized tOnset values at voxel level.
Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St. Thomas¿ Hospital, London, U.K.
Niloufar
N
Zarinabad
Philips Group Innovation¿Healthcare Incubators, Philips Research High Tech Campus, Eindhoven, AE, The Netherlands.
Gilion L T F
GLTF
Hautvast
Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St. Thomas¿ Hospital, London, U.K.
Eva
E
Sammut
Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St. Thomas¿ Hospital, London, U.K.
Aruna
A
Arujuna
Philips Healthcare, Imaging Systems¿MR, Best, DA, The Netherlands.
Marcel
M
Breeuwer
Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St. Thomas¿ Hospital, London, U.K.
Eike
E
Nagel
Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St. Thomas¿ Hospital, London, U.K.
Amedeo
A
Chiribiri
D057791:Cardiac Imaging Techniques / Q000379:methods*; D016022:Case-Control Studies; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics*; D003324:Coronary Artery Disease / Q000503:physiopathology; D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D019047:Phantoms, Imaging
D003287:Contrast Media