Intraoperative platelet-rich plasma does not improve outcomes of total knee arthroplasty.
This randomized controlled study was conducted to assess the effects of platelet-rich plasma (PRP) on outcomes of total knee arthroplasty (TKA). Forty patients who underwent unilateral TKA were evaluated prospectively; 20 received intraoperative PRP and 20 served as control subjects. The results showed no significant differences in reduction of bleeding, range of motion, swelling around the knee joint, muscle power recovery, pain, Knee Society Scores, and Knee Injury and Osteoarthritis Outcome Score between the 2 groups. Additionally, no distinct clinical characteristics were found in patients who received intraoperative PRP. Therefore, we conclude that intraoperative PRP does not improve outcomes of TKA.
Department of Orthopaedic Surgery, Hyogo Rehabilitation Center Hospital, Japan.
Masayuki
M
Morishita
Department of Orthopaedic Surgery, Hyogo Rehabilitation Center Hospital, Japan; Department of Orthopaedic Surgery, Kobe Kaisei Hospital, Japan.
Kazunari
K
Ishida
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan.
Tomoyuki
T
Matsumoto
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan.
Ryosuke
R
Kuroda
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan.
Masahiro
M
Kurosaka
Department of Orthopaedic Surgery, Hyogo Rehabilitation Center Hospital, Japan.
Nobuhiro
N
Tsumura
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000517:prevention & control; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D020370:Osteoarthritis, Knee / Q000601:surgery* / Q000628:therapy; D010149:Postoperative Pain / Q000517:prevention & control; D053657:Platelet-Rich Plasma; D016059:Range of Motion, Articular; D016896:Treatment Outcome
D006490:Hemostatics; D036341:Intercellular Signaling Peptides and Proteins
bleeding; functional score; platelet-rich plasma; postoperative recovery; total knee arthroplasty