Long-term effects of nanoparticles on nutrition and metabolism.
Nanoparticles have shown great potential in biological and biomedical applications due to their distinct physical and chemical properties. In the meanwhile, the biosafety of nanoparticles has also raised intense concerns worldwide. To address such concerns, great efforts have been made to examine short-term effects of nanoparticles on cell survival and proliferation. More recently, exploration of long-term effects of nanomaterials, particularly those with promising biomedical applications in vivo, has aroused significant interest. For example, gold nanoparticles (AuNPs) are generally considered non-toxic to cell growth, whereas recent studies suggest that AuNPs might have long-term effects on cellular metabolism and energy homeostasis. In this Review, recent advances in this direction are summarized. Further, possible mechanisms under which nanoparticles regulate metabolic signaling pathways, potential long-term effects on cellular anabolic or catabolic processes, and their implications in human health and metabolic disorders are discussed.
Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of sciences, Shanghai, 200031, China; Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
Nan
N
Chen
Hui
H
Wang
Qing
Q
Huang
Jiang
J
Li
Juan
J
Yan
Dannong
D
He
Chunhai
C
Fan
Haiyun
H
Song
D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D008247:Lysosomes / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008660:Metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009747:Nutritional Physiological Phenomena; D052756:Nutritional Sciences; D015398:Signal Transduction / Q000187:drug effects
D006046:Gold; D005947:Glucose
autophagy; metabolic signaling pathways; nanoparticles; oxidative stress