[Correlation of thyroid-stimulating hormone with metabolic syndrome in euthyroid male elders].
OBJECTIVE
To explore the relationship between thyroid-stimulating hormone (TSH) and metabolic syndrome (MS) and its components in euthyroid male elders.


METHODS
For this cross-sectional study, 307 euthyroid male elders aged over 60 years participating in a routine annual health screening examination at our hospital during May-June 2011 were enrolled. Their mean age was (72.6 ± 7.9) years. Height, weight, blood pressure, blood glucose, blood lipids, fasting insulin levels and thyroid functions (TT3, TT4, FT3, FT4, TSH, TgAb & TPOAb) were measured. And the association of thyroid functions and the presence of MS and its components was analyzed.


RESULTS
The prevalence of MS was 40.7% (125/307). The TSH level was significantly higher in the MS and obese group than that in control group ((2.6 ± 1.1) vs (2.4 ± 1.0) mU/L, P = 0.014; (2.7 ± 1.1) vs (2.3 ± 1.1)mU/L, P = 0.007). The prevalence of MS and obesity showed a gradual increase according to the TSH tertiles. When comparing subjects in the highest and lowest tertile of TSH, the former group demonstrated 1.872 and 1.904-fold increases in the odds ratio for obesity and MS after adjusting for age and homeostasis model assessment for insulin resistance (HOMA-IR) (95%CI: 1.051-3.332, P = 0.033; 95%CI: 1.070-3.387, P = 0.028) . Logistic regression analysis showed that the TSH levels were independent influencing factors for MS in male elders (OR = 1.324, 95%CI:1.042-1.683) .


CONCLUSIONS
High circulating TSH level, albeit normal, is associated with elevated risk for metabolic syndrome in male elders.
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Haiying
H
Xiao
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Yanhui
Y
Lu
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Xiaoling
X
Cheng
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Fusheng
F
Fang
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Yanping
Y
Gong
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Zhibing
Z
Li
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Jian
J
Li
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Hui
H
Tian
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China. Email: lichunlin301@163.com.
Chunlin
C
Li
D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D015995:Prevalence; D013972:Thyrotropin / Q000097:blood*
D013972:Thyrotropin