Preparation and characterization of silver nanoparticles-loaded calcium alginate beads embedded in gelatin scaffolds.
Silver nanoparticles (AgNPs)-loaded alginate beads embedded in gelatin scaffolds were successfully prepared. The AgNPs-loaded calcium alginate beads were prepared by electrospraying method. The effect of alginate concentration and applied voltage on shape and diameter of beads was studied. The diameter of dry AgNPs-loaded calcium alignate beads at various concentrations of AgNO3 ranged between 154 and 171 μm. The AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were fabricated by freeze-drying method. The water swelling and weight loss behaviors of the AgNPs-loaded alginate beads embedded in gelatin scaffolds increased with an increase in the submersion time. Moreover, the genipin-cross-linked gelatin scaffolds were proven to be nontoxic to normal human dermal fibroblasts, suggesting their potential uses as wound dressings.
School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, 57100, Thailand.
Porntipa
P
Pankongadisak
Uracha Rungsardthong
UR
Ruktanonchai
Pitt
P
Supaphol
Orawan
O
Suwantong
D000464:Alginates / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents; D005079:Excipients / Q000737:chemistry; D005612:Freeze Drying; D005780:Gelatin / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D039823:Iridoids / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012834:Silver / Q000737:chemistry*
D000464:Alginates; D003432:Cross-Linking Reagents; D005079:Excipients; D006603:Hexuronic Acids; D039823:Iridoids; D012834:Silver; D020723:Glucuronic Acid; D005780:Gelatin; C007834:genipin