Critical limb ischemia: current approach and future directions.
Patients with critical limb ischemia (CLI) represent the highest risk patients with peripheral artery disease (PAD), with high rates of death, amputation, and other cardiovascular events. Previously, nonsurgical options for patients with CLI were limited. However, advances in endovascular techniques such as angiosome-based revascularization and technologies such as drug-eluting balloon and stent platforms have dramatically improved the therapeutic outlook. Additionally, advances in stem cell-based therapy and angiogenic factors show promise as adjuvant medical therapy.
University of Virginia Health System, Charlottesville, VA, USA, kps2u@virginia.edu.
Kanwar P
KP
Singh
Aditya M
AM
Sharma
D000818:Animals; D016638:Critical Illness; D054855:Drug-Eluting Stents; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D033581:Stem Cell Transplantation; D016896:Treatment Outcome; D062666:Vascular Access Devices