Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: a pooled analysis of 4500 patients.
Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I(2)=41%; p-value for heterogeneity=0.13}.
Adventist Wockhardt Heart Institute, Surat Gujarat India. Electronic address: salildeo@yahoo.co.in.
Salil V
SV
Deo
Jordan University of Science and Technology, Irbid Jordan.
Abeer
A
Rababa'h
Queen Alia Heart Institute, Amman Jordan.
Salah E
SE
Altarabsheh
Asan Medical Center, Seoul, South Korea.
Ju Yong
JY
Lim
Samsung Medical Center, Sungkyunkwan University of Medical Sciences, Seoul, South Korea.
Yang Hyun
YH
Cho
Case Medical Center, Case Western Reserve University Cleveland OH USA.
Soon J
SJ
Park
D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000188:drug therapy* / Q000401:mortality*; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015996:Survival Rate
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
Dilated cardiomyopathy; Heart failure; HydroxylglutarylCoA reductase inhibitiors; Non-ischemic cardiomyopathy; Statin