[Autoimmune mechanisms toward type I collagen during parodontitis].
The article presents original data about autoimmune mechanisms according to the severity of the process during the chronic generalized Parodontitis. The medical examination of 179 patients with different forms of Parodontitis demonstrated that during Parodontitis the synthesis and re-synthesis of type I Collagen is negatively affected and as a result, type I Collagen concentration in the blood serum raises. In addition, the selection of antigen reactive lymphocytes increases toward Type I Collagen, which in turn boosts their quantity in blood and also stimulates the creation of auto-antibodies toward Type I Collagen. This is reflected by the increased quantity of auto-antibodies in the blood serum. The intensity of these processes amplifies as the Parodontitis inflammation becomes more severe. These results demonstrate that the autoimmune process develops toward Type I Collagen during Parodontitis and its intensity reflects the severity of the pathological processes in Parodontitis.
D001323:Autoantibodies / Q000097:blood; D024042:Collagen Type I / Q000097:blood* / Q000276:immunology*; D006801:Humans; D010518:Periodontitis / Q000276:immunology*
D001323:Autoantibodies; D024042:Collagen Type I