Comparative release studies of two cationic model drugs from different cellulose nanocrystal derivatives.
Native cellulose nanocrystal (CNC), oxidized CNC (CNC-OX) and chitosan oligosaccharide grafted CNC (CNC-CSOS) were evaluated as potential drug delivery carriers for two model drug compounds, procaine hydrochloride (PrHy) and imipramine hydrochloride (IMI). The loading of PrHy and IMI was performed at pH 8 and 7, respectively. IMI displayed higher binding to CNC derivatives than PrHy. Drug selective membranes were prepared for each model drug and a drug selective electrode system was used to measure the drug concentration in the filtrate and release medium. Isothermal Titration Calorimetry (ITC) was used to elucidate the types of interactions between model drugs and CNC and its derivatives. The complexation between model drugs and CNC derivatives was confirmed by zeta potential and transmittance measurements. The binding and release of these drugs correlated with the nature and types of interactions that exist between the CNC and drug molecules.
Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada. Electronic address: spakhlag@uwaterloo.ca.
Seyedeh Parinaz
SP
Akhlaghi
Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada.
Daryl
D
Tiong
CelluForce Inc., Montreal, QC, Canada.
Richard M
RM
Berry
Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada. Electronic address: mkctam@uwaterloo.ca.
Kam Chiu
KC
Tam
D002138:Calibration; D002151:Calorimetry; D002412:Cations / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004566:Electrodes; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007099:Imipramine / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D009844:Oligosaccharides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011343:Procaine / Q000737:chemistry; D011485:Protein Binding; D055672:Static Electricity
D002412:Cations; D004337:Drug Carriers; D009844:Oligosaccharides; D011108:Polymers; D011343:Procaine; D002482:Cellulose; D007099:Imipramine
Cellulose nanocrystals; Drug selective electrode; Imipramine hydrochloride; In vitro drug release; Isothermal titration calorimetry; Procaine hydrochloride