Antimicrobial Susceptibility Profile of Extended Spectrum β-Lactamase (ESBL) Producing Escherichia coli from Various Clinical Samples.
BACKGROUND
Extended spectrum β-lactamase (ESBL) producing Escherichia coli has tremendously increased worldwide and it is one of the most common causes of morbidity and mortality associated with hospital-acquired infections. This could be attributed to association of multi drug resistance in ESBL producing isolates. The present study was aimed to determine the antimicrobial sensitivity profile of ESBL producing E. coli isolates from various clinical samples.


METHODS
Clinical samples, which consist of pus, urine, blood, cerebrospinal fluid (CSF), stool, sputum, swabs, and different body fluids, are included in the study. Samples were processed and identified as per routine laboratory protocol. ESBL screening and confirmation along with antimicrobial susceptibility test was done according to the Clinical Laboratory Standards Institute (CLSI) guidelines.


RESULTS
Out of 180 third generation cephalosporins resistant E. coli, 100 (55.55%) isolates were ESBL producers showing a greater degree of resistance to antibiotics.


CONCLUSIONS
The prevalence of ESBL is increasing day by day in nearly every center of different countries and necessary steps to prevent the spread and emergence of resistance should be taken.
Department of Microbiology, Gold Field Institute of Medical Sciences and Research, Faridabad, Haryana, India.
Dinesh
D
Kumar
Department of Microbiology, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India.
Amit Kumar
AK
Singh
Department of Microbiology, School of Medical Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, India.
Mohammad Rashid
MR
Ali
Department of Microbiology, School of Medical Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, India.
Yogesh
Y
Chander
DDS; E. coli; ESBL; ESBL producing E. coli