The regulation of inflammatory mediators in acute kidney injury via exogenous mesenchymal stem cells.
Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. Various preclinical studies indicated the beneficial effects of MSCs in alleviating renal injury and accelerating tissue repair. However the mechanisms responsible for these effects are incompletely understood. In the recent years, anti-inflammatory/immunoregulatory properties of MSCs have become one of the important issues in the treatment of AKI. This review will summarize the current literature on the regulation of inflammatory mediators via exogenous MSCs contributing to the recovery from AKI.
Department of Urology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, China ; Department of Urology, Henan Provincial People's Hospital, No. 7 Weiwu Road, Zhengzhou 450003, China.
Tao
0000-0001-7989-3208
T
Du
Department of Urology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, China.
Ying-Jian
YJ
Zhu
D058186:Acute Kidney Injury / Q000276:immunology* / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007668:Kidney / Q000276:immunology / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000276:immunology* / Q000502:physiology*
D018925:Chemokines; D016207:Cytokines