Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: an observational study.
OBJECTIVE
To explore the expression patterns of Eag1 (ether á go-go 1) and HIF-1α (hypoxia-inducible factor 1α) in a cohort of patients with breast cancer.


METHODS
Department of general surgery in an upper first-class hospital in Xi'an, China.


METHODS
A total of 112 female Han Chinese patients with a diagnosis of invasive ductal carcinoma were included. Patients with main internal diseases, such as cardiovascular, endocrine, gastroenterological, haematological, infectious diseases, etc, were excluded.


METHODS
Expression profiles of Eag1 and HIF-1α.


RESULTS
Eag1 and HIF-1α were overexpressed in the tumour tissues compared with the pair-matched control tissues, p=0.002 and <0.001, respectively. The expression of Eag1 and HIF-1α was negatively correlated with tumour size, p=0.032 and p=0.025, respectively, and lymph node status (p=0.040, p=0.032, respectively). The coexpression of Eag1 and HIF-1α was correlated with tumour size (p=0.012), lymph node status (p=0.027) and tumour stage (p=0.036). HIF-1α has a strong correlation with hEag1 expression (κ=0.731, p<0.001).


CONCLUSIONS
HIF-1α expression has a strong correlation with hEag1 expression. We are the first to attempt to explore the correlation at the population level.
College of Life Science, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Qingxuan
Q
Lai
Department of General Surgery, Xijing Hospital, Xi'an, People's Republic of China.
Ting
T
Wang
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, People's Republic of China.
Qingqing
Q
Guo
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, People's Republic of China.
Yuxiang
Y
Zhang
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, People's Republic of China.
Youxin
Y
Wang
College of Life Science, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Li
L
Yuan
Department of General Surgery, Xijing Hospital, Xi'an, People's Republic of China.
Rui
R
Ling
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, People's Republic of China.
Yan
Y
He
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, People's Republic of China School of Medical Sciences, Edith Cowan University, Perth, Australia.
Wei
W
Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D051638:Ether-A-Go-Go Potassium Channels / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
D014408:Biomarkers, Tumor; D051638:Ether-A-Go-Go Potassium Channels; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C496884:KCNH1 protein, human
Histopathology; Molecular Biology