Hierarchical biointerfaces assembled by leukocyte-inspired particles for specifically recognizing cancer cells.
By mimicking certain biochemical and physical attributes of biological cells, bio-inspired particles have attracted great attention for potential biomedical applications based on cell-like biological functions. Inspired by leukocytes, hierarchical biointerfaces are designed and prepared based on specific molecules-modified leukocyte-inspired particles. These biointerfaces can efficiently recognize cancer cells from whole blood samples through the synergistic effect of molecular recognition and topographical interaction. Compared to flat, mono-micro or nano-biointerfaces, these micro/nano hierarchical biointerfaces are better able to promote specific recognition interactions, resulting in an enhanced cell-capture efficiency. It is anticipated that this study may provide promising guidance to develop new bio-inspired hierarchical biointerfaces for biomedical applications.
Laboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Science, Beijing, 100190, P. R. China.
Jingxin
J
Meng
Hongliang
H
Liu
Xueli
X
Liu
Gao
G
Yang
Pengchao
P
Zhang
Shutao
S
Wang
Lei
L
Jiang
D008841:Actin Cytoskeleton / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000378:metabolism; D032701:Biomimetics; D015815:Cell Adhesion Molecules / Q000378:metabolism; D045744:Cell Line, Tumor; D000071858:Epithelial Cell Adhesion Molecule; D006358:Hot Temperature; D006801:Humans; D007962:Leukocytes / Q000166:cytology*; D061986:MCF-7 Cells; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D013499:Surface Properties
D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule
bioinspired materials; cancer cells; hierarchical structures; specific recognition; structure-property relationships