Dragmacidoside: a new nucleoside from the Red Sea sponge Dragmacidon coccinea.
Chemical investigation of the Red Sea sponge Dragmacidon coccinea led to the isolation of a new nucleoside, dragmacidoside (1), along with eight known compounds: adenosine (2), inosine (3), deoxycytidine (4), methyl-α-d-glucopyranoside (5), clionasterol (6), stigmasterol (7), campesterol (8) and brassicasterol (9). The compounds were isolated from chloroform and ethyl acetate fractions of the methanolic extract of the sponge, and their structures were established based on various spectroscopic data including MS, 1D and 2D NMR (COSY, HSQC and HMBC). Biological testing revealed that the chloroform fraction possesses significant anti-inflammatory activity in the carrageenan-induced hind paw oedema in rats.
a Department of Natural Products and Alternative Medicine , Faculty of Pharmacy, King Abdulaziz University , Jeddah 21589 , Saudi Arabia.
Dina R
DR
Abou-Hussein
Jihan M
JM
Badr
Diaa T A
DT
Youssef
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D002351:Carrageenan / Q000009:adverse effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D019156:Indian Ocean; D008386:Marine Biology; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D012855:Sitosterols; D013265:Stigmasterol
D000893:Anti-Inflammatory Agents; D009705:Nucleosides; D012855:Sitosterols; C000592947:dragmacidoside; C025473:gamma-sitosterol; D002351:Carrageenan; D013265:Stigmasterol
Dragmacidon coccinea; Red Sea sponges; anti-inflammatory activity; dragmacidoside; nucleosides; steroids