Graphene oxide assisted fluorescent chemodosimeter for high-performance sensing and bioimaging of fluoride ions.
Fluorescent chemodosimeters for a fluoride ion (F(-)) based on a specifically F(-)-triggered chemical reaction are characterized by high selectivity. However, they are also subjected to intrinsic limits, such as long response time, poor stability under aqueous solution, and unpredictable cell-member penetration. To address these issues, we reported here that the self-assembly of fluorescent chemodosimeter molecules on a graphene oxide (GO) surface can solve these problems by taking advantage of the excellent chemical catalysis and nanocarrier functions of GO. As a proof of concept, a new F(-)-specific fluorescent chemodosimeter molecule, FC-A, and the GO self-assembly structure of GO/FC-A were synthesized and characterized. Fluorescent sensing and imaging of F(-) with FC-A and GO/FC-A were performed. The results showed that the reaction rate constant of GO/FC-A for F(-) is about 5-fold larger than that of FC-A, so that the response time was shortened from 4 h to about 30 min, while for F(-), the response sensitivity of GO/FC-A was >2-fold higher than that of FC-A. Furthermore, GO/FC-A showed a better bioimaging performance for F(-) than FC-A because of the nanocarrier function of GO for cells. It is demonstrated that this GO-based strategy is feasible and general, which could help in the exploration of the development of more effective fluorescent nanodosimeters for other analytes of interest.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, and Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University , Changsha 410082, China.
Changyao
C
Wang
Sheng
S
Yang
Mei
M
Yi
Changhui
C
Liu
Yijun
Y
Wang
Jishan
J
Li
Yinhui
Y
Li
Ronghua
R
Yang
D015374:Biosensing Techniques; D002384:Catalysis; D004396:Coloring Agents / Q000737:chemistry; D005453:Fluorescence; D005459:Fluorides / Q000737:chemistry / Q000302:isolation & purification*; D006108:Graphite / Q000737:chemistry*; D057054:Molecular Imaging; D010087:Oxides / Q000737:chemistry*
D004396:Coloring Agents; D010087:Oxides; D006108:Graphite; D005459:Fluorides