Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al (2014) use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.
Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences Medical School Newcastle University, Newcastle upon Tyne, UK.
Robert N
RN
Lightowlers
Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences Medical School Newcastle University, Newcastle upon Tyne, UK.
Zofia M A
ZM
Chrzanowska-Lightowlers
D000818:Animals; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D017240:Mitochondrial Myopathies / Q000188:drug therapy*; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011726:Pyridinium Compounds; D014803:Vitamin B Complex / Q000627:therapeutic use*
D011726:Pyridinium Compounds; C018613:nicotinamide-beta-riboside; D014803:Vitamin B Complex; D009536:Niacinamide