Detrusor underactivity: Pathophysiological considerations, models and proposals for future research. ICI-RS 2013.
OBJECTIVE
Detrusor underactivity, resulting in either prolonged or inefficient voiding, is a common clinical problem for which treatment options are currently limited. The aim of this report is to summarize current understanding of the clinical observation and its underlying pathophysiological entities.


METHODS
This report results from presentations and subsequent discussion at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, 2013.


CONCLUSIONS
The recommendations made by the ICI-RS panel include: Development of study tools based on a system's pathophysiological approach, correlation of in vitro and in vivo data in experimental animals and humans, and development of more comprehensive translational animal models. In addition, there is a need for longitudinal patient data to define risk groups and for the development of screening tools. In the near-future these recommendations should lead to a better understanding of detrusor underactivity and its pathophysiological background. Neurourol. Urodynam. 33:591-596, 2014. © 2014 Wiley Periodicals, Inc.
Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Gommert A
GA
van Koeveringe
Kevin L J
KL
Rademakers
Lori A
LA
Birder
Cees
C
Korstanje
Firouz
F
Daneshgari
Michael R
MR
Ruggieri
Yasuhiko
Y
Igawa
Christopher
C
Fry
Adrian
A
Wagg
D000375:Aging / Q000502:physiology*; D048909:Diabetes Complications / Q000503:physiopathology*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D059411:Lower Urinary Tract Symptoms / Q000378:metabolism / Q000503:physiopathology*; D009130:Muscle, Smooth / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology; D001743:Urinary Bladder / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D001748:Urinary Bladder Neck Obstruction / Q000503:physiopathology*; D014555:Urination Disorders / Q000378:metabolism / Q000503:physiopathology
ageing; detrusor underactivity; experimental animal models; lower urinary tract symptoms; underactive bladder; urinary tract physiology; voiding dysfunction