Anatomic and hormonal changes in the female reproductive tract immune environment during the life cycle: implications for HIV/STI prevention research.
The female genital tract undergoes anatomic changes from birth through menopause. Concurrently, the relative levels and roles of estradiol and progesterone dramatically change during the female life cycle. This review provides a conceptual overview of clinically relevant anatomic and hormonal changes in the female genital tract, and how these changes may affect HIV-1 pathogenesis, transmission, and mucosal immunology and protection against HIV and STIs across the female life cycle.
Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kartik K
KK
Venkatesh
Susan
S
Cu-Uvin
D004958:Estradiol / Q000378:metabolism*; D005260:Female; D005836:Genitalia, Female / Q000033:anatomy & histology / Q000378:metabolism / Q000821:virology; D015658:HIV Infections / Q000276:immunology / Q000473:pathology* / Q000635:transmission; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D008597:Menstrual Cycle; D009092:Mucous Membrane / Q000276:immunology*; D011374:Progesterone / Q000378:metabolism*; D046468:Sexual Development / Q000502:physiology; D012749:Sexually Transmitted Diseases / Q000276:immunology / Q000382:microbiology / Q000821:virology
D011374:Progesterone; D004958:Estradiol
Anatomy; HIV; STI; female genital tract; hormones; women