A one-pot hypoiodite catalysed oxidative cycloetherification approach to benzoxazoles.
A practical one-pot hypoiodite catalysed oxidative cyclization approach to synthesize α-ketobenzoxazole derivatives was successfully developed. This operationally simple protocol utilizes easily-accessible starting materials and has a broad substrate scope with excellent yields.
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan. jjwang@kmu.edu.tw.
Siva Senthil Kumar
SS
Boominathan
Wan-Ping
WP
Hu
Gopal Chandru
GC
Senadi
Jaya Kishore
JK
Vandavasi
Jeh-Jeng
JJ
Wang
D001583:Benzoxazoles / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D004987:Ethers / Q000138:chemical synthesis; D007202:Indicators and Reagents; D017613:Iodine Compounds / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction
D001583:Benzoxazoles; D004987:Ethers; D007202:Indicators and Reagents; D017613:Iodine Compounds; D016877:Oxidants; C081961:hypoiodous acid