[Clinical significance of serum telomerase mRNA in patients with prostate cancer].
OBJECTIVE
To explore the clinical significance of detecting serum mRNA of telomerase in the diagnosis of prostate cancer.


METHODS
Serum samples were collected from 29 patients with prostate cancer and 29 age-matched patients with cardiovascular or metabolic disease as non-tumor controls. Sera samples from 15 healthy age-matched subjects were used as healthy control. Detection of serum telomerase mRNA was performed with real-time reverse transcriptase quantitative polymerase chain reaction (PCR).


RESULTS
Serum telomerase mRNA was detectable in 89.7% (26/29) patients with prostate cancer, but almost undetectable in non-tumor (6.9%, 2/29) and healthy control groups(1/14).


CONCLUSIONS
Using real-time PCR for detecting serum telomerase mRNA may be an auxiliary method for diagnosing and monitoring of prostate cancer.
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China. Email: zhongmeihanjian@sina.com.
Lei
L
Ge
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Zhongjie
Z
Shan
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Qianhe
Q
Han
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Jianting
J
Hu
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Huiming
H
Liu
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Qingjun
Q
Guan
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Xiaowei
X
Qu
Department of Urology, Zhengzhou People's Hospital, Zhengzhou 450003, China.
Kun
K
Chen
D000368:Aged; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000097:blood*; D012333:RNA, Messenger / Q000097:blood* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019098:Telomerase / Q000097:blood* / Q000235:genetics
D012333:RNA, Messenger; D019098:Telomerase