Extensive cerebral white matter involvement in a patient with NMO spectrum disorder.
Abnormal brain MRI has been described in up to 60% of patients with NMO patients. However, white matter T2 hyperintensities have been rarely observed. We report the case of a 49-year-old woman with long-lasting neuromyelitis optica (NMO) spectrum disorder and diffuse cerebral white matter T2-weighted hyperintensities. Our case suggests that some NMO patients can progressively develop l extensive cerebral involvement.
CHU Montpellier, France xavier.ayrignac@yahoo.fr.
Xavier
X
Ayrignac
CHU Montpellier, France.
Clarisse Carra
CC
Dalière
CHU Montpellier, France.
Elodie
E
Nerrant
CHU Montpellier, France.
Thierry
T
Vincent
CHRU Strasbourg, France.
Jérôme
J
De Seze
CHU Montpellier, France.
Pierre
P
Labauge
D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D056784:Leukoencephalopathies / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011237:Predictive Value of Tests; D013997:Time Factors; D016896:Treatment Outcome; D066127:White Matter / Q000473:pathology*
C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D015415:Biomarkers; D007166:Immunosuppressive Agents
Devic’s syndrome; Neuromyelitis Optica; white matter disease