Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators.
Covering: 1973 to 2013. The biological activities of tigliane, lathyrane, ingenane, casbane, jatropholane and premyrsinane diterpenoids which contain the gem-dimethylcyclopropyl unit are described. Particular attention is given to their anti-viral, anti-microbial and cytotoxic activities. In the main text there are 132 references. The electronic supplementary information contains tables listing 424 of these diterpenoids, their occurrence and biological activity together with the references.
Department of Organic Chemistry, Faculty of Science, University of Cádiz, Polígono Río San Pedro s/n, 11510, Puerto Real (Cádiz), Spain. isidro.gonzalez@uca.es rosario.hernandez@uca.es.
María Jesús
MJ
Durán-Peña
José Manuel
JM
Botubol Ares
Isidro G
IG
Collado
Rosario
R
Hernández-Galán
D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003521:Cyclopropanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
D001688:Biological Products; D003521:Cyclopropanes; D004224:Diterpenes; D011493:Protein Kinase C