Trend analysis of diabetic prevalence and incidence in a rural area of South Korea between 2003-2008.
Aims/Introduction:  This study determined the change in prevalence of diabetes and prediabetes over a period of 5 years in South Korea. The incidence of diabetes and prediabetes and risk factors associated with the development of diabetes were also investigated.


METHODS
The Dalseong population-based cohort survey recruited 1806 subjects who were over 20-years-old in 2003. Five years later, 1287 of the original subjects were re-evaluated and 187 new subjects were added to the study. All participants completed a questionnaire, were given a physical examination, and provided blood samples for analysis including 2 h oral glucose tolerances.


RESULTS
Age-adjusted prevalence of diabetes rose from 6.7% in 2003 to 9.1% in 2008. The prevalence of prediabetes also increased from 18.5% in 2003 to 28.4% in 2008. The incidence rates of diabetes and prediabetes were 18.3 per 1000 person-years and 55.4 per 1000 person-years, respectively. The development of diabetes was associated with impaired fasting glucose (IFG) (odds ratio [OR] 5.661), impaired glucose tolerance (IGT) (OR: 6.013), age (OR 1.013), and waist-to-hip ratio (OR 1.513). After excluding the IFG and IGT, systolic blood pressure (OR 1.023), high-sensitivity C-reactive protein (hsCRP; OR 1.097), triglyceride (OR 1.002) and waist-to-hip ratio (OR 1.696) were statistically significant risk factors in a multivariate logistic regression analysis.


CONCLUSIONS
A significant rise in the prevalence of diabetes and prediabetes was observed between 2003 and 2008. In addition, this study newly demonstrated that waist-to-hip ratio and hsCRP were associated with the development of diabetes after adjusting for several confounding factors. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00045.x, 2010).
Department of Internal Medicine, Kyungpook National University School of Medicine.
Ji Yun
JY
Jeong
Department of Internal Medicine, Kyungpook National University School of Medicine.
Jung-Guk
JG
Kim
Department of Internal Medicine, Kyungpook National University School of Medicine.
Bo-Wan
BW
Kim
Department of Internal Medicine, Kyungpook National University School of Medicine.
Seong Su
SS
Moon
Department of Internal Medicine, School of Medicine, Keimyung University.
Hye-Soon
HS
Kim
Department of Internal Medicine, School of Medicine, Keimyung University.
Keun-Gyu
KG
Park
Department of Internal Medicine, College of Medicine, Yeungnam University.
Kyu Chang
KC
Won
Department of Internal Medicine, College of Medicine, Yeungnam University.
Hyoung Woo
HW
Lee
Department of Internal Medicine, College of Medicine, Yeungnam University.
Ji Sung
JS
Yoon
Department of Internal Medicine, School of Medicine, Catholic University of Daegu.
Ho-Sang
HS
Shon
Department of Internal Medicine, School of Medicine, Catholic University of Daegu.
Ji Hyun
JH
Lee
Department of Internal Medicine, School of Medicine, Catholic University of Daegu.
Eui-Dal
ED
Jung
Dalseong Healthcare Center.
Mi Young
MY
Park
Department of Preventive Medicine, Kyungpook National University School of Medicine.
Byung-Yeol
BY
Chun
Department of Preventive Medicine, Kyungpook National University School of Medicine.
Keon-Yeop
KY
Kim
Department of Preventive Medicine and Public Health, College of Medicine, Yeungnam University.
Tae-Yoon
TY
Hwang
Department of Preventive Medicine, School of Medicine, Keimyung University.
Mi-Young
MY
Lee
Department of Internal Medicine, Kyungpook National University School of Medicine ; WCU project "Development for new drug-target in complication of metabolic syndrome", Kyungpook National University School of Medicine ; Research Institute for Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.
In-Kyu
IK
Lee
Diabetes mellitus; Prevalence; South Korea