Synthesis and biological activities of certain mesoionic sydnone compounds containing chalcone moiety.
In order to have antibacterial, analgesic and anti-inflammatory activity in the same molecule, 4-[1-oxo-3- (substituted aryl)-2-propenyl]-3-(4-chlorophenyl) sydnones were synthesized by condensing 4-acetyl-3-(4-chlorophenyl)sydnone with various substituted aryl aldehydes and characterized by spectral studies; 4-acetyl-3-(4-chlorophenyl)sydnone itself, was prepared by acetylation of 3-(4-chlorophenyl) sydnone. The newly synthesized compounds were evaluated for antibacterial and anti-inflammatory activities by cup plate and carrageenan induced rat paw edema methods respectively. Some of the compounds showed promising antibacterial and anti-inflammatory activities.
Department of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, BVVS Campus, Bagalkote-587 101, Karnataka, India.
Shreenivas R
SR
Deshpande
Department of Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Shivamogga District, Karnataka, India.
K Vasantakumar
KV
Pai
Synthesis; anti-inflammatory; antibacterial; chalcone; sydnone