Three new resveratrol derivatives from the mangrove endophytic fungus Alternaria sp.
Three new resveratrol derivatives, namely, resveratrodehydes A-C (1-3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC50 < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC₅₀ < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay.
Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China. alanwongjh@sina.com.
Jinhua
J
Wang
Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, Mississippi University, Oxford, MS 38677, USA. dgcox@go.olemiss.edu.
Daniel G
DG
Cox
Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China. dwjzsu@scau.edu.cn.
Weijia
W
Ding
Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China. ghhscau@sina.com.
Guanghao
G
Huang
School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.
Yongcheng
Y
Lin
Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China. chunyuanli@scau.edu.cn.
Chunyuan
C
Li
D000528:Alternaria / Q000737:chemistry* / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry*; D045744:Cell Line, Tumor; D005285:Fermentation; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D031643:Myoporum / Q000382:microbiology; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D016166:Free Radical Scavengers; D013267:Stilbenes; D000077185:Resveratrol