Structural biology: a 'funny' cyclic dinucleotide receptor.
Deciphering the molecular basis of HCN channel regulation by cGMP leads to the serendipitous discovery of cyclic dinucleotides as potent inhibitors of I(f) current in the heart.
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington.
Yoni
Y
Haitin
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D015226:Dinucleoside Phosphates / Q000378:metabolism*; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / Q000378:metabolism*; D015640:Ion Channel Gating / Q000502:physiology*; D009124:Muscle Proteins / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*
D015226:Dinucleoside Phosphates; C119587:HCN4 protein, human; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D009124:Muscle Proteins; D015221:Potassium Channels; C528998:cyclic diadenosine phosphate; C062025:bis(3',5')-cyclic diguanylic acid; D000242:Cyclic AMP; D006152:Cyclic GMP