Passenger Lymphocyte Syndrome: A Case Report Involving Non-ABO Antibodies.
BACKGROUND
Passenger lymphocyte syndrome (PLS) is most often a result of an ABO minor mismatch between stem cell or solid organ donor and recipient. Relatively few cases of PLS have been reported resulting from non-ABO red cell antibodies.


METHODS
A blood group O/Rh-positive patient received a stem cell transplant from an A/Rh-negative donor who had an identifiable anti-D. Even though the plasma of the stem cell product was reduced and replaced with an electrolyte solution, the recipient developed a positive antibody screen, positive direct antiglobulin test, and significant hemolysis 8 days after transplantation.


CONCLUSIONS
PLS can result from non-ABO antibodies and can be associated with a significant degree of hemolysis.
Medical University of South Carolina, Charleston, SC, USA.
Jerry E
JE
Squires
Hemolysis; PLS; Passenger lymphocyte syndrome; Transplantation