Macrophages in homeostatic immune function.
Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders.
Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen, Germany.
Jonathan
J
Jantsch
Experimental and Clinical Research Center (ECRC), Max-Delbrück Center for Molecular Medicine, Charité Medical Faculty Berlin, Germany.
Katrina J
KJ
Binger
Experimental and Clinical Research Center (ECRC), Max-Delbrück Center for Molecular Medicine, Charité Medical Faculty Berlin, Germany.
Dominik N
DN
Müller
Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen, Germany ; Divison of Clinical Pharmacology, Vanderbilt University School of Medicine Nashville, TN, USA.
Jens
J
Titze
Na+ storage; angiogenesis; arteriogenesis; lipid metabolism; macrophage polarization; peroxisome proliferator activator receptor (PPAR); salt; tonicity enhance binding protein (TonEBP)/nuclear factor of activated T-cells 5(NFAT5)