Pathogen-like particles: biomimetic vaccine carriers engineered at the nanoscale.
Vaccine adjuvants are an essential component of vaccine design, helping to generate immunity to pathogen antigens in the absence of infection. Recent advances in nanoscale engineering have created a new class of particulate bionanotechnology that uses biomimicry to better integrate adjuvant and antigen. These pathogen-like particles, or PLPs, can come from a variety of sources, ranging from fully synthetic platforms to biologically derived, self-assembling systems. By employing molecularly engineered targeting and stimulation of key immune cells, recent studies utilizing PLPs as vaccine delivery platforms have shown great promise against high-impact, unsolved vaccine targets ranging from bacterial and viral pathogens to cancer and addiction.
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.
Joseph A
JA
Rosenthal
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Linxiao
L
Chen
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Jenny L
JL
Baker
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA. Electronic address: dap43@cornell.edu.
David
D
Putnam
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA. Electronic address: md255@cornell.edu.
Matthew P
MP
DeLisa
D000276:Adjuvants, Immunologic; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D032701:Biomimetics; D004337:Drug Carriers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D014612:Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology; D058425:Vaccines, Virus-Like Particle / Q000008:administration & dosage / Q000276:immunology*
D000276:Adjuvants, Immunologic; D001672:Biocompatible Materials; D004337:Drug Carriers; D014612:Vaccines; D014614:Vaccines, Synthetic; D058425:Vaccines, Virus-Like Particle