Red cell distribution width predicts contrast-induced nephropathy in patients undergoing percutaneous coronary intervention for acute coronary syndrome.
We investigated the relationship between red cell distribution width (RDW) and contrast-induced nephropathy (CIN) in patients (aged 61 ± 12, 69% men) with acute coronary syndrome (ACS). Consecutive patients diagnosed with ACS (n = 662) who underwent percutaneous coronary intervention (PCI) were included in the study. Patients were divided into 2 groups: CIN and no CIN. Contrast-induced nephropathy was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 hours after PCI. Contrast-induced nephropathy occurred in 81 (12.2%) patients. Red cell distribution width, creatinine, and high-sensitivity C-reactive protein levels were significantly higher in the CIN group than in the no-CIN group. Multivariate regression analysis revealed that baseline RDW level (odds ratio 1.379, 95% confidence interval 1.084-1.753, P = .009), age (P = .025), creatinine (P = .004), and left ventricular ejection fraction (P = .011) were independent risk factors for the development of CIN. In conclusion, increased RDW levels are independently associated with a greater risk of CIN in patients undergoing PCI for ACS.
Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey alpkurtul@yahoo.com.
Alparslan
A
Kurtul
Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
Mikail
M
Yarlioglues
Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
Sani Namik
SN
Murat
Department of Cardiology, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.
Muhammed Bora
MB
Demircelik
Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
Sadik Kadri
SK
Acikgoz
Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
Gokhan
G
Ergun
Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
Mustafa
M
Duran
Department of Cardiology, Numune Education and Research Hospital, Ankara, Turkey.
Mustafa
M
Cetin
Department of Cardiology, Numune Education and Research Hospital, Ankara, Turkey.
Ender
E
Ornek
D054058:Acute Coronary Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011237:Predictive Value of Tests; D015641:Radiography, Interventional / Q000009:adverse effects*; D012307:Risk Factors; D013318:Stroke Volume; D016896:Treatment Outcome; D015854:Up-Regulation; D016277:Ventricular Function, Left
D015415:Biomarkers; D003287:Contrast Media; D018836:Inflammation Mediators; D002097:C-Reactive Protein; D003404:Creatinine
acute coronary syndrome; contrast-induced nephropathy; percutaneous coronary intervention; red cell distribution width