Oxidative stress and paraoxonase 1 activity predict contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Reactive oxygen species have been implicated in the pathogenesis of contrast-induced nephropathy (CIN). We investigated the relationship between CIN with paraoxonase 1 (PON-1) activity and oxidative stress markers (total antioxidant status [TAS], total oxidant status [TOS], and oxidative stress index [OSI]) in patients with anterior ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention; 289 consecutive patients with STEMI were prospectively included. The patients were divided into 2 groups: CIN (n = 69) and non-CIN (n = 220). Activity of PON-1 and TAS levels were significantly lower and OSI and TOS levels were significantly higher in patients with CIN compared to the non-CIN group (P < .05, for all). On multivariate logistic regression analysis, PON-1 activity and OSI as well as the amount of contrast medium and diabetes were independent predictors for CIN in patients with anterior STEMI. Activity of PON-1 and oxidative stress may play a role in the pathogenesis of CIN.
Department of Cardiology, School of Medicine, Kafkas University, Kars, Turkey.
Abdurrezzak
A
Börekçi
Department of Cardiology, School of Medicine, Kafkas University, Kars, Turkey drmugur@yahoo.com.
Mustafa
M
Gür
Department of Cardiology, Yenimahalle State Hospital, Ankara, Turkey.
Caner
C
Türkoğlu
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Murat
M
Çaylı
Department of Biochemistry, School of Medicine, Harran University, Şanlıurfa, Turkey.
Şahbettin
Ş
Selek
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Onur
O
Kaypaklı
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Hakan
H
Uçar
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Mehmet
M
Coşkun
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Taner
T
Şeker
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Mevlüt
M
Koç
Department of Cardiology, School of Medicine, Kafkas University, Kars, Turkey.
Teyyar
T
Gökdeniz
Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey.
Mehmet Yavuz
MY
Gözükara
D000328:Adult; D000368:Aged; D056988:Anterior Wall Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000628:therapy*; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D048909:Diabetes Complications / Q000139:chemically induced; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D015415:Biomarkers; D003287:Contrast Media; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
contrast; infarction; nephropathy; oxidative stress; paraoxonase