Horsfiequinones A-F, dimeric diarylpropanoids from Horsfieldia tetratepala.
A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B-F (2-6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B-F (2-6), isolated as enantiomer mixtures with unequal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC50 values ranging from 3.18 ± 0.67 to 6.61 ± 0.08 µM.
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Qin
Q
Ma
Diqing Institute of Agricultural Science, Shangrila, Yunnan, China.
Kang
K
Min
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Hao-Liang
HL
Li
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Jin-He
JH
Jiang
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Ying
Y
Liu
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Rui
R
Zhan
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Ye-Gao
YG
Chen
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D026324:Myristicaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D010936:Plant Extracts; D020005:Propanols; C004532:quinone