The potential role of magnetic resonance spectroscopy in image-guided radiotherapy.
Magnetic resonance spectroscopy (MRS) is a non-invasive technique to detect metabolites within the normal and tumoral tissues. The ability of MRS to diagnose areas of high metabolic activity linked to tumor cell proliferation is particularly useful for radiotherapy treatment planning because of better gross tumor volume (GTV) delineation. The GTV may be targeted with higher radiation dose, potentially improving local control without excessive irradiation to the normal adjacent tissues. Prostate cancer and glioblastoma multiforme (GBM) are two tumor models that are associated with a heterogeneous tumor distribution. Preliminary studies suggest that the integration of MRS into radiotherapy planning for these tumors is feasible and safe. Image-guided radiotherapy (IGRT) by virtue of daily tumor imaging and steep dose gradient may allow for tumor dose escalation with the simultaneous integrated boost technique (SIB) and potentially decrease the complications rates in patients with GBM and prostate cancers.
Department of Psychology, Stanford University , Palo Alto, CA , USA.
Mai Lin
ML
Nguyen
School of Medicine, University of Arizona , Phoenix, AZ , USA.
Brooke
B
Willows
Department of Radiology, University of Arizona , Tucson, AZ , USA.
Rihan
R
Khan
Department of Radiation Oncology, University of West Virginia , Morgantown, WV , USA.
Alexander
A
Chi
Division of Neuro-Oncology, Department of Neurosurgery and Medical Oncology, Thomas Jefferson University , Philadelphia, PA , USA.
Lyndon
L
Kim
Department of Radiology, Emory University , Atlanta, GA , USA.
Sherif G
SG
Nour
Department of Radiation Oncology, Darmouth College , New Lebanon, NH , USA.
Thomas
T
Sroka
Department of Radiation Oncology, Centre Val d'Aurelle , Montpellier , France.
Christine
C
Kerr
Department of Radiation Oncology, Florida Radiation Oncology Group , Jacksonville, FL , USA.
Juan
J
Godinez
Department of Radiation Oncology, University of Arizona , Tucson, AZ , USA.
Melissa
M
Mills
Department of Radiation Oncology, Marshfield Clinic , Marshfield, WI , USA.
Ulf
U
Karlsson
Department of Radiation Oncology, Camden Clark Cancer Center , Parkersburg, WV , USA.
Gabor
G
Altdorfer
Department of Radiation Oncology, Howard University Hospital , Washington DC , USA.
Nam Phong
NP
Nguyen
Department of Radiation Oncology, East Carolina University , Greenville, NC , USA.
Gordon
G
Jendrasiak
GBM; IGRT; MRS; prostate cancer