Profile of acute kidney injury in pediatric leptospirosis.
OBJECTIVE
Leptospirosis is an emerging public health zoonotic disease driven by climate and environment. Reports on leptospirosis-induced acute kidney injury (AKI) in children are scant and lacking in detail. The main objective is to provide an accurate and comprehensive description of AKI in pediatric leptospirosis.


METHODS
We reviewed records of children ≤ 18 years old referred to the Section of Pediatric Nephrology in a tertiary-level government hospital from January 2004 to December 2012. They presented with clinical manifestations of leptospirosis and a microscopic agglutination test (MAT) ≥ 1:400. Patients were stratified as oliguric and non-oliguric with the former having a urine output of <0.5 mL/kg/h.


RESULTS
A total of 86 cases were included with 53 children (62%) presenting with oliguria during their confinement. Blood urea nitrogen (BUN) (p=0.04) and serum creatinine (p=0.01) levels were significantly more elevated in the oliguric subjects than the non-oliguric children upon hospital admission with a median estimated GFR (eGFR) of 9 and 11 mL/min per 1.73 m(2), respectively. Peritoneal dialysis (PD) was initiated in 19 (36%) patients in the oliguric group. Death occurred in 2 (4%) subjects with oliguric AKI. The most common pathologic serovars isolated were L. manilae (13%) and L. poi (13%).


CONCLUSIONS
Anicteric oliguric AKI due to leptospirosis is more frequent and severe than non-oliguric kidney failure in the pediatric population.
Department of Physiology, University of the Philippines-College of Medicine, University of the Philippines Manila , Philippines .
Francisco E
FE
Anacleto
Almira B
AB
Collado
Angeli M
AM
Wyson
D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007922:Leptospirosis / Q000150:complications*; D008297:Male; D010679:Philippines / Q000453:epidemiology; D012189:Retrospective Studies
Acute kidney injury; leptospirosis; pediatric nephrology; peritoneal diaysis; tropical disease