Delivering healthy mitochondria for the therapy of mitochondrial diseases and beyond.
Mitochondrial transfer has been demonstrated to a play a physiological role in the rescuing of mitochondrial DNA deficient cells by co-culture with human mesenchymal stem cells. The successful replacement of mitochondria using microinjection into the embryo has been revealed to improve embryo maturation. Evidence of mitochondrial transfer has been shown to minimize injury of the ischemic-reperfusion rabbit heart model. In this mini review, the therapeutic strategies of mitochondrial diseases based on the concept of mitochondrial transfer are illustrated, as well as a novel approach to peptide-mediated mitochondrial delivery. The possible mechanism of peptide-mediated mitochondrial delivery in the treatment of the myoclonic epilepsy and ragged-red fiber disease is summarized. Understanding the feasibility of mitochondrial manipulation in cells facilitates novel therapeutic skills in the future clinical practice of mitochondrial disorder.
Vascular and Genomic Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan; Department of Neurology, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan. Electronic address: liu26602@gmail.com.
Chin-San
CS
Liu
Vascular and Genomic Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan.
Jui-Chih
JC
Chang
Department of Surgery, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan.
Shou-Jen
SJ
Kuo
Vascular and Genomic Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan.
Ko-Hung
KH
Liu
Vascular and Genomic Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan.
Ta-Tsung
TT
Lin
Vascular and Genomic Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan.
Wen-Ling
WL
Cheng
Vascular and Genomic Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 50094, Taiwan.
Sheng-Fei
SF
Chuang
D000818:Animals; D003543:Cysteamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000473:pathology* / Q000637:transplantation; D028361:Mitochondrial Diseases / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010455:Peptides / Q000627:therapeutic use*; D011817:Rabbits
D004272:DNA, Mitochondrial; C503924:Pep-1 peptide; D010455:Peptides; D003543:Cysteamine
Mitochondrial diseases; Mitochondrial transfer; Pep-1; Therapeutics; Transplantation