Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.
An effective HIV-1 vaccine should elicit sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus. Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment. We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.
Los Alamos National Laboratory, Los Alamos, NM, United States.
Elena E
EE
Giorgi
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Harikrishnan
H
Balachandran
University of Manchester School of Mathematics, Manchester M60 1QD, UK.
Mark
M
Muldoon
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Norman L
NL
Letvin
Duke University Human Vaccine Institute, Durham, NC, United States; Duke Center for HIV/AIDS Vaccine Immunology, Durham, NC, United States.
Barton F
BF
Haynes
Los Alamos National Laboratory, Los Alamos, NM, United States; Santa Fe Institute, Santa Fe, NM, United States.
Bette T
BT
Korber
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address: ssantra@bidmc.harvard.edu.
Sampa
S
Santra
D003429:Cross Reactions; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000145:classification*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D054301:gag Gene Products, Human Immunodeficiency Virus
Cross-clade response; HIV-1; T lymphocyte