Ruthenium-catalyzed cyclization of ketoxime acetates with DMF for synthesis of symmetrical pyridines.
A novel ruthenium-catalyzed cyclization of ketoxime carboxylates with N,N-dimethylformamide (DMF) for the synthesis of tetrasubstituted symmetrical pyridines has been developed. A methyl carbon on DMF performed as a source of a one carbon synthon. And NaHSO3 plays a role in the reaction.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710069, P. R. China.
Mi-Na
MN
Zhao
Rong-Rong
RR
Hui
Zhi-Hui
ZH
Ren
Yao-Yu
YY
Wang
Zheng-Hui
ZH
Guan
D000085:Acetates / Q000737:chemistry*; D003500:Cyclization; D004126:Dimethylformamide / Q000737:chemistry*; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
D000085:Acetates; D010091:Oximes; D011725:Pyridines; D012428:Ruthenium; D004126:Dimethylformamide