Pregnancy rates in donor oocyte cycles compared to similar autologous in vitro fertilization cycles: an analysis of 26,457 fresh cycles from the Society for Assisted Reproductive Technology.
OBJECTIVE
To use a large US IVF database and compare pregnancy outcomes in fresh donor oocyte versus autologous IVF cycles in women age 20-30 years.


METHODS
Retrospective cohort study.


METHODS
Not applicable.


METHODS
Women undergoing fresh autologous ovarian stimulation, and oocyte donors and recipients in the United States between 2008 and 2010.


METHODS
None.


METHODS
Implantation, clinical pregnancy (CP), and live birth (LB) rates.


RESULTS
Despite similar demographics, stimulation, and embryo parameters, donor oocyte recipients had significantly higher rates of implantation, CP, and LB compared to those undergoing fresh autologous cycles. Odds ratios for implantation, CP, and LB significantly favored the donor oocyte group in all comparisons, including those limited to intracytoplasmic sperm injection cycles, intracytoplasmic sperm injection with male factor, unexplained infertility, cleavage stage embryo transfer, blastocyst transfer, elective single blastocyst transfer, and autologous patients with prior tubal ligation.


CONCLUSIONS
Recent US data suggest that the hormonal environment resulting from autologous ovarian stimulation lowers IVF success rates. Further research is needed to determine when to avoid fresh embryo transfer in autologous patients.
Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
Jason S
JS
Yeh
Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
Ryan G
RG
Steward
Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
Annie M
AM
Dude
Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
Anish A
AA
Shah
University Hospitals Fertility Center, Beachwood, Ohio.
James M
JM
Goldfarb
Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina. Electronic address: muashersj@gmail.com.
Suheil J
SJ
Muasher
D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000009:adverse effects; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D016017:Odds Ratio; D018587:Oocyte Donation; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome; D014481:United States; D055815:Young Adult
Ovarian; detrimental; endometrial; receptivity; stimulation