Cancer biology in diabetes.
Diabetes is a serious metabolic disease that causes multiple organ dysfunctions. Recent evidence suggests that diabetes could contribute to the initiation and progression of certain cancers in addition to the classic diabetic complications. Furthermore, some of the drugs used clinically to treat patients with diabetes might affect cancer initiation, progression and mortality. The recent discovery of the possible anticancer effects of metformin, a classic antidiabetic drug, has led physicians and scientists to reconsider the interaction between diabetes and cancer. In the present review, we analyze recent reports in this field, and explore possible mechanistic links between diabetes and cancer biology.
Division of Diabetes & Endocrinology Kanazawa Medical University Ishikawa Japan ; The Department of Vascular and Thyroid Surgery The Affiliated Hospital of Luzhou Medical College Luzhou China.
Shi
S
Sen
The Department of Vascular and Thyroid Surgery The Affiliated Hospital of Luzhou Medical College Luzhou China.
Yanzheng
Y
He
Division of Diabetes & Endocrinology Kanazawa Medical University Ishikawa Japan.
Daisuke
D
Koya
Division of Diabetes & Endocrinology Kanazawa Medical University Ishikawa Japan.
Keizo
K
Kanasaki
Antidiabetic drugs; Cancer; Diabetes