Mitophagy mechanisms and role in human diseases.
Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.
Center for Free Radical Biology, University of Alabama at Birmingham, USA; Department of Pathology, University of Alabama at Birmingham, USA.
Matthew
M
Redmann
Center for Free Radical Biology, University of Alabama at Birmingham, USA; Department of Pathology, University of Alabama at Birmingham, USA.
Matthew
M
Dodson
Université de Franche-Comté, Laboratoire de Biochimie, EA3922, SFR IBCT FED4234, Sciences et Techniques, 16 route de Gray, 25030 Besançon Cedex, France.
Michaël
M
Boyer-Guittaut
Center for Free Radical Biology, University of Alabama at Birmingham, USA; Department of Pathology, University of Alabama at Birmingham, USA.
Victor
V
Darley-Usmar
Center for Free Radical Biology, University of Alabama at Birmingham, USA; Department of Pathology, University of Alabama at Birmingham, USA; Department of Veterans Affairs, Birmingham VA Medical Center, AL 35294, USA. Electronic address: zhanja@uab.edu.
Jianhua
J
Zhang
D006331:Heart Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D053078:Membrane Potential, Mitochondrial; D063306:Mitophagy / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
Cancer; Heart disease; Mitochondria; Mitophagy; Parkinson's disease