Expression profiles of variation integration genes in bladder urothelial carcinoma.
Bladder cancer is a common cancer worldwide and its incidence continues to increase. There are approximately 261,000 cases of bladder cancer resulting in 115,000 deaths annually. This study aimed to integrate bladder cancer genome copy number variation information and bladder cancer gene transcription level expression data to construct a causal-target module network of the range of bladder cancer-related genomes. Here, we explored the control mechanism underlying bladder cancer phenotype expression regulation by the major bladder cancer genes. We selected 22 modules as the initial module network to expand the search to screen more networks. After bootstrapping 100 times, we obtained 16 key regulators. These 16 key candidate regulatory genes were further expanded to identify the expression changes of 11,676 genes in 275 modules, which may all have the same regulation. In conclusion, a series of modules associated with the terms 'cancer' or 'bladder' were considered to constitute a potential network.
Department of Urology, Yantai Yuhuangding Hospital, Yantai City, Shandong Province, China.
J M
JM
Wang
Department of Urology, Yantai Yuhuangding Hospital, Yantai City, Shandong Province, China.
Y Q
YQ
Wang
Department of Urology, Yantai Yuhuangding Hospital, Yantai City, Shandong Province, China.
Z L
ZL
Gao
Department of Urology, Yantai Yuhuangding Hospital, Yantai City, Shandong Province, China.
J T
JT
Wu
Department of Urology, Qilu Hospital, Jinan City, Shandong Province, China shiyucuikang356@hotmail.com.
B K
BK
Shi
Department of Urology, Yantai Yuhuangding Hospital, Yantai City, Shandong Province, China.
C C
CC
Yu
D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000473:pathology; D056915:DNA Copy Number Variations / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D059467:Transcriptome; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
D009363:Neoplasm Proteins