The role of bone morphogenetic proteins in myeloma cell survival.
Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are important for several aspects of myeloma pathogenesis including growth and survival of tumor cells, bone homeostasis, and anemia. Among cancer cells, myeloma cells are particularly sensitive to growth inhibition and apoptosis induced by BMPs and therefore represent good models to study BMP receptor usage and signaling. Our review highlights and discusses the current knowledge on BMP signaling in myeloma.
KG Jebsen Center for Myeloma Research, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway. Electronic address: toril.holien@ntnu.no.
Toril
T
Holien
KG Jebsen Center for Myeloma Research, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway. Electronic address: anders.sundan@ntnu.no.
Anders
A
Sundan
D000818:Animals; D017209:Apoptosis; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002470:Cell Survival; D006801:Humans; D008954:Models, Biological; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D015398:Signal Transduction
D019485:Bone Morphogenetic Proteins; D009363:Neoplasm Proteins
Apoptosis; BMP; Bone morphogenetic protein; Multiple myeloma