Synthesis of spiro[isoquinolinone-4,2'-oxiranes] and isoindolinones via a multicomponent reaction of 2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile.
Efficient synthesis of spiro[isoquinolinone-4,2'-oxiranes] was achieved based on a multicomponent one-pot reaction of readily available cis-2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile at room temperature. However, in the reaction with trans-2-acetyl-oxirane-2-carboxamide substrates, 3-iminoisoindolinones were obtained in moderate to high yields.
Department of Chemistry, Northeast Normal University, Changchun 130024, China. liangfs112@nenu.edu.cn.
Bing
B
Liu
Enxiang
E
Wei
Shaoxia
S
Lin
Baozhong
B
Zhao
Fushun
F
Liang