Duodenal adenocarcinoma might be the cause of intractable nausea and vomiting in patient with coeliac disease.
Coeliac disease (CD) is an autoimmune disorder which leads to chronic inflammation of the gut. Untreated CD is associated with upper gastrointestinal malignancies, Small-bowel lymphoma and adenocarcinoma are recognized complications of untreated coeliac disease (CD). We report the case of a 43-year-old male suffering from CD who was treated with a gluten-free diet one year, presenting with complaints of intractable nausea and vomiting. After several studies, He underwent push enteroscopy, which identified one large mass lesion in the third part of duodenum. However, histopathological examination showed adenocarcinoma. Subsequently, a duodenal segment resection was performed. After surgery, the patient recovered well and left our hospital in good condition. Clinicians should take into small bowel adenocarcinoma is rare but associated with CD particularly in CD patients with worrying symptoms such as nausea and vomiting unresponsiveness to treatment and these patients should be screened for long term complications like malignancy.
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hassan
H
Rajabalinia
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza
R
Dabiri
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahin
S
Shahbazi
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi
M
Ghobakhlou
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rasoul
R
Bahreiny
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahsa
M
Molaei
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad
M
Rostami Nejad
Gastroenterology and Liver diseases Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Reza
SR
Fatemi
Adenocarcinoma; Coeliac disease; Malignancy