Ambroxol-induced focal epileptic seizure.
It is well known that in epileptic patients some compounds and different drugs used for the treatment of comorbidities can facilitate or provoke seizures, this evidence regarding a wide spectrum of pharmacological categories. The potential facilitating factors usually include direct toxic effects or pharmacological interactions of either active ingredients or excipients. We report the case of a patient with drug-resistant epilepsy who experienced focal epileptic seizures, easily and constantly reproducible, after each administration of a cough syrup. This is, to our knowledge, the first electroencephalogram-documented case of focal epileptic seizures induced by cough syrup containing ambroxol as active ingredient.
Epilepsy Unit, Department of Neurological Sciences, "Sapienza" University of Rome, Rome, Italy.
Leonardo
L
Lapenta
Alessandra
A
Morano
Jinane
J
Fattouch
Sara
S
Casciato
Martina
M
Fanella
Anna Teresa
AT
Giallonardo
Carlo
C
Di Bonaventura
D000293:Adolescent; D000551:Ambroxol / Q000009:adverse effects*; D000927:Anticonvulsants / Q000627:therapeutic use; D000996:Antitussive Agents / Q000009:adverse effects*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004828:Epilepsies, Partial / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D004366:Nonprescription Drugs / Q000009:adverse effects*; D012008:Recurrence
D000927:Anticonvulsants; D000996:Antitussive Agents; D004366:Nonprescription Drugs; D000551:Ambroxol