Single-nucleotide-resolution DNA differentiation by pattern generation in lipid bilayer membranes.
Pattern generation/recognition in lipid bilayers is introduced for the differentiation of anionic biological relevant polymers. The amplification of the polymer differences during transport events allows the straightforward identification of a wide range collection of anionic polymers. The introduced approach displays excellent resolution even for single mutations in short single-stranded oligonuclotides.
Singular research centre in chemical biology and molecular materials (CIQUS) and Organic Chemistry Department, University of Santiago de Compostela (USC), E-15782, Santiago de Compostela, Spain.
Juan M
JM
Priegue
Javier
J
Montenegro
Juan R
JR
Granja
D000818:Animals; D000838:Anions; D001704:Biopolymers / Q000737:chemistry; D002412:Cations; D002462:Cell Membrane / Q000378:metabolism*; D004247:DNA / Q000737:chemistry*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D009154:Mutation; D009711:Nucleotides / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013696:Temperature
D000838:Anions; D001704:Biopolymers; D002412:Cations; D008051:Lipid Bilayers; D009711:Nucleotides; D009841:Oligonucleotides; D010455:Peptides; D011108:Polymers; D004247:DNA
DNA; amphiphiles; biomembranes; dynamic covalent chemistry; pattern generation; pattern recognition; transport