Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate.
A 22-year-old man was referred to our hospital with macroscopic hematuria and consistent anal pain. Magnetic resonance imaging revealed an enlarged prostate tumour invading the bladder and rectum. A biopsy revealed an unclassified spindle cell sarcoma. Subsequently, radical cystoprostatectomy and resection of the rectum were performed. A histopathological examination revealed a prostatic malignant phyllodes tumour with a negative surgical margin. However, a local recurrence was identified 2 months after surgery. Induction therapy included 4 cycles of systemic chemotherapy comprising etoposide with ifosfamide and cisplatin. Although a partial response was observed at the local site, lung metastasis developed. Second-line chemotherapy with ifosfamide and doxorubicin with radiotherapy to the pelvis was administered and led to complete regression; however, its efficacy was transient. Although additional chemotherapy was administered, the patient eventually died due to the rapidly growing, recurrent tumour.
Department of Urology, Kitasato University School of Medicine, Japan;
Yasukiyo
Y
Murakami
Department of Urology, Kitasato University School of Medicine, Japan;
Ken-Ichi
K
Tabata
Department of Urology, Kitasato University School of Medicine, Japan;
Atsushi
A
Sugita
Department of Urology, Kitasato University School of Medicine, Japan;
Kohei
K
Mochizuki
Department of Urology, Kitasato University School of Medicine, Japan;
Ryota
R
Maeyama
Department of Pharmacology, Kitasato University School of Medicine, Japan;
Miyoko
M
Okazaki
Department of Urology, Kitasato University School of Medicine, Japan;
Morihiro
M
Nishi
Department of Urology, Kitasato University School of Medicine, Japan;
Kazumasa
K
Matsumoto
Department of Urology, Kitasato University School of Medicine, Japan;
Tetsuo
T
Fujita
Department of Urology, Kitasato University School of Medicine, Japan;
Takefumi
T
Satoh
Department of Pathology, Kitasato University School of Medicine, Japan.
Shi-Xu
SX
Jiang
Department of Pathology, Kitasato University School of Medicine, Japan.
Makoto
M
Saegusa
Department of Urology, Kitasato University School of Medicine, Japan;
Masatsugu
M
Iwamura