Glanzmann thrombasthenia associated with human immunodeficiency virus-positive patient.
Glanzmann's thrombasthenia (GT) is an autosomal recessive inherited platelet function defect characterized by normal platelet count, prolonged bleeding time and abnormal clot retraction. This disease typically presents in infancy or early childhood and has proven to have very good prognosis. In this case study, a 22-year-old GT patient who also developed human immunodeficiency virus (HIV) infection after sometime is reported. The patient showed oral manifestations of gingival hyperplasia and petechial lesions. Unfortunately the detection of both thrombasthenia and HIV were done at considerably late stages which contributed to a poor prognosis. The patient died of cardiopulmonary arrest secondary to HIV, thrombasthenia and thrombocytopenia. The importance of early detection, supportive care and communication between the general and oral physician in management of the GT is also discussed.
Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh, India.
Rakesh Kumar
RK
Manne
Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh, India.
Kannan
K
Natarajan
Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh, India.
Rajendra
R
Patil
Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh, India.
Venkata Sarath
VS
Prathi
Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh, India.
Swapna Sridevi
SS
Beeraka
Department of Oral Medicine and Radiology, Narayana Dental College and Hospital, Chintareddypalem, Nellore, Andhra Pradesh, India.
Venkata Suneel Kumar
VS
Kolaparthi
Glanzmann thrombasthenia; IIb/IIIa glycoprotein complex; gingival hyperplasia; human immunodeficiency virus; thrombocytopenia