The glomerulopathy of sickle cell disease.
Sickle cell disease (SCD) produces many structural and functional abnormalities in the kidney, including glomerular abnormalities. Albuminuria is the most common manifestation of glomerular damage, with a prevalence between 26 and 68% in adult patients. The pathophysiology of albuminuria in SCD is likely multifactorial, with contributions from hyperfiltration, glomerular hypertension, ischemia-reperfusion injury, oxidative stress, decreased nitric oxide (NO) bioavailability, and endothelial dysfunction. Although its natural history in SCD remains inadequately defined, albuminuria is associated with increased echocardiography-derived tricuspid regurgitant jet velocity, systemic blood pressure, and hypertension, as well as history of stroke, suggesting a shared vasculopathic pathophysiology. While most patients with albuminuria are treated with angiotensin converting enzyme inhibitors/angiotensin receptor blockers, there are no published long-term data on the efficacy of these agents. With the improved patient survival following kidney transplantation, SCD patients with end-stage renal disease should be considered for this treatment modality. Given the high prevalence of albuminuria and its association with multiple SCD-related clinical complications, additional studies are needed to answer several clinically important questions in a bid to adequately elucidate its pathophysiology, natural history, and treatment.
Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC.
Kenneth I
KI
Ataga
Vimal K
VK
Derebail
David R
DR
Archer
D000419:Albuminuria / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000652:urine; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000652:urine; D057911:Angiotensin Receptor Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000652:urine; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000652:urine; D016030:Kidney Transplantation
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors