Deregulated expression of connective tissue growth factor (CTGF/CCN2) is linked to poor outcome in human cancer.
Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific. Recurring patterns in clinical outcome, histological desmoplasia and mechanisms of action have been found. When CTGF is overexpressed compared to low-expressing normal tissue or is underexpressed compared to high-expressing normal tissue, the functional outcome favours tumour survival and disease progression. CTGF acts by altering proliferation, drug resistance, angiogenesis, adhesion and migration contributing to metastasis. The pattern of CTGF expression and tumour response helps to clarify the role of this matricellular protein across a multitude of human cancers.
Leukaemia and Cancer Division, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.|School of Paediatrics and Child Health, The University of Western Australia, Perth, WA, Australia.
Julia E
JE
Wells
Leukaemia and Cancer Division, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.
Meegan
M
Howlett
School of Paediatrics and Child Health, The University of Western Australia, Perth, WA, Australia.
Catherine H
CH
Cole
Leukaemia and Cancer Division, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.
Ursula R
UR
Kees
D002448:Cell Adhesion / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D055513:Connective Tissue Growth Factor / Q000235:genetics* / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics; D009928:Organ Specificity / Q000235:genetics; D063868:Patient Outcome Assessment; D011379:Prognosis
D055513:Connective Tissue Growth Factor
CCN2; cancer; connective tissue growth factor (CTGF)