Molecular characterization, expression profiles, and analysis of Qinchuan cattle SIRT1 gene association with meat quality and body measurement traits (Bos taurus).
Silent information regulator (SIRT1), was closely associated with senescence, metabolism, and apoptosis. The objective of this study was to investigate whether SIRT1 gene could be used as a candidate gene in the breeding process of Qinchuan cattle. Via sequencing technology conducted in 453 individuals of Qinchuan cattle, single nucleotide polymorphisms (G25764A, A25846G, and T25868C) with 5 haplotypes and 6 combined genotypes in 3' untranslated region of SIRT1 gene were identified. In addition, three loci were significantly associated with some of the body measurements and meat quality traits in Qinchuan cattle (P < 0.05), and the H2H2 (GG-AA-CC) diplotypes had better performance than other combinations in Qinchuan cattle. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Linsheng
L
Gui
Hongbao
H
Wang
Shengjuan
S
Wei
Yaran
Y
Zhang
Linsen
L
Zan
D020413:3' Untranslated Regions; D000483:Alleles; D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D019295:Computational Biology; D005091:Exons; D063427:Food Quality; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D008460:Meat / Q000032:analysis*; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D056564:Sirtuin 1 / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome
D020413:3' Untranslated Regions; D056564:Sirtuin 1