Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia.
Zygomycosis is a lethal and invasive mold infection that is often associated with hematological malignancies. The keys for successful treatment include making a rapid diagnosis and appropriately administering antifungal agents. We herein report the early diagnosis of a case of zygomycosis in a patient with acute myeloid leukemia using a deoxyribonucleic acid sequence analysis. We successfully performed allogeneic hematopoietic stem cell transplantation with the use of high-dose liposomal amphotericin B and granulocyte transfusion.
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Japan.
Junichiro
J
Yuda
Koji
K
Kato
Yoshikane
Y
Kikushige
Kiyofumi
K
Ohkusu
Makiko
M
Kiyosuke
Keiji
K
Sakamoto
Seido
S
Oku
Noriko
N
Miyake
Masako
M
Kadowaki
Tadafumi
T
Iino
Kazuki
K
Tanimoto
Katsuto
K
Takenaka
Hiromi
H
Iwasaki
Toshihiro
T
Miyamoto
Nobuyuki
N
Shimono
Takanori
T
Teshima
Koichi
K
Akashi
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D020103:Rhizomucor / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA
D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D016179:Granulocyte Colony-Stimulating Factor; D000666:Amphotericin B