[Risk factors of bloodstream infections caused by Enterobacteriaceae and related prognostic factors in general intensive care unit].
OBJECTIVE
To explore the risk factors and its related prognostic factors of hospital-acquired bloodstream infections caused by enterobacteriaceae in general intensive care unit (GICU).


METHODS
The clinical data of hospital-acquired bloodstream infections caused by enterobacteriaceae in general intensive care unit from January 2007 to December 2012 were retrospectively analyzed to determine the risk factors and explore the related prognostic factors of bloodstream infections by mono-factor and Logistic regression analysis.


RESULTS
There were 35 cases BSI caused by enterobacteriaceae in all 96 patients with hospital-acquired bloodstream infections and the mortality was 42.9% (n = 15). The relevant risk factors included acute pancreatitis, abdominal surgery and use of antacids (P < 0.05 or 0.01) after a comparison of baseline conditions and clinical characteristics of patients between BSI caused by enterobacteriaceae and non-enterobacteriaceae. And the single factor and multi-factor Logistic regression analysis showed that their prognostic factors included patient age, acute physiology and chronic health evaluation (APACHE) II score, tracheal intubation or incision and extended-spectrum beta-lactamase (ESBL) positive (P < 0.05).


CONCLUSIONS
The patients admitted into general intensive care unit with acute pancreatitis, abdominal surgery and use of antacids are more likely to suffer from EBSI. And patient age, APACHE II score, tracheal intubation or incision and ESBL are important prognostic factors.
Intensive Care Unit, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, China.
Fuxi
F
Sun
Email: zhu1635253@163.com.
Ganzhu
G
Feng
Tianming
T
Gao
Yang
Y
Zhang
Shuidi
S
Zhao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000209:etiology*; D003428:Cross Infection / Q000209:etiology* / Q000382:microbiology; D004755:Enterobacteriaceae; D004756:Enterobacteriaceae Infections / Q000209:etiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors