Multifunctional roles of reticular fibroblastic cells: more than meets the eye?
Fibroblastic reticular cells (FRCs) are stromal cells found in secondary lymphoid organ. Despite its structural function in the lymph nodes being well established, recent studies indicate that the FRCs also play a key role in immunological processes, associated with cell transit, immune response, and cells activation quality, and contribute to peripheral tolerance. To this end, we focus this review on lymph nodes FRC characterization and discuss functional aspects such as production of cytokines and chemokines and their involvement in the immune response, seeking to establish whether certain subsets have a more functional specialization.
Experimental Research, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, 05152 000 São Paulo, SP, Brazil ; Programa de Alergia e Imunopatologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Av. Dr. Arnaldo, 455, 01418 200 São Paulo, SP, Brazil.
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Alvarenga
Experimental Research, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, 05152 000 São Paulo, SP, Brazil ; Programa de Alergia e Imunopatologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Av. Dr. Arnaldo, 455, 01418 200 São Paulo, SP, Brazil.
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Marti
D000818:Animals; D002465:Cell Movement; D002470:Cell Survival; D003239:Connective Tissue Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D061166:Peripheral Tolerance / Q000276:immunology; D010641:Phenotype; D011323:Primates