A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.
TGF-β signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.
Department of Molecular Biology, LTL255, Washington Road, Princeton University, Princeton, NJ 08544, USA.
Wenyang
W
Li
Department of Molecular Biology, LTL255, Washington Road, Princeton University, Princeton, NJ 08544, USA. Electronic address: ykang@princeton.edu.
Yibin
Y
Kang
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D062085:RNA, Long Noncoding / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D062085:RNA, Long Noncoding; D016212:Transforming Growth Factor beta