Label-free, optical sensing of the supramolecular assembly into fibrils of a ditryptophan-DNA hybrid.
The grafting of a short nucleic acid strand to ditryptophan dipeptide (WW) results in a peptide-DNA hybrid, which assembles into fibrils under controlled aggregation conditions as evidenced by label free optical sensing owing to the intrinsic fluorescence of the dipeptide.
University of Geneva, Faculty of Sciences, Department of Inorganic and Analytical Chemistry, 1211 Geneva 4, Switzerland. corinne.vebert@unige.ch.
Nidhi
N
Gour
Jancy Nixon
JN
Abraham
Mohamed
M
Chami
Axel
A
Castillo
Sandeep
S
Verma
Corinne
C
Vebert-Nardin
D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis / Q000737:chemistry*; D004151:Dipeptides / Q000032:analysis / Q000737:chemistry*; D005453:Fluorescence; D015394:Molecular Structure; D061848:Optical Imaging; D013050:Spectrometry, Fluorescence; D014364:Tryptophan / Q000032:analysis / Q000737:chemistry*
D004151:Dipeptides; D014364:Tryptophan; D004247:DNA