Childhood physical abuse predicts stressor-evoked activity within central visceral control regions.
Early life experience differentially shapes later stress reactivity, as evidenced by both animal and human studies. However, early experience-related changes in the function of central visceral neural circuits that control stress responses have not been well characterized, particularly in humans. The paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST), amygdala (Amyg) and subgenual anterior cingulate cortex (sgACC) form a core visceral stress-responsive circuit. The goal of this study is to examine how childhood emotional and physical abuse relates to adulthood stressor-evoked activity within these visceral brain regions. To evoke acute states of mental stress, participants (n = 155) performed functional magnetic resonance imaging (fMRI)-adapted versions of the multi-source interference task (MSIT) and the Stroop task with simultaneous monitoring of mean arterial pressure (MAP) and heart rate. Regression analyses revealed that childhood physical abuse correlated positively with stressor-evoked changes in MAP, and negatively with unbiased, a priori extractions of fMRI blood-oxygen level-dependent signal change values within the sgACC, BNST, PVN and Amyg (n = 138). Abuse-related changes in the function of visceral neural circuits may reflect neurobiological vulnerability to adverse health outcomes conferred by early adversity.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA Labst94@pitt.edu.
Layla
L
Banihashemi
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Lei K
LK
Sheu
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Aimee J
AJ
Midei
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Peter J
PJ
Gianaros
D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D062186:Arterial Pressure; D001931:Brain Mapping; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D003866:Depressive Disorder / Q000523:psychology; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010286:Paraventricular Hypothalamic Nucleus / Q000503:physiopathology; D000066550:Physical Abuse / Q000523:psychology*; D012686:Septal Nuclei / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology*; D057190:Stroop Test
abuse; amygdala; bed nucleus of the stria terminalis; hypothalamus; stress