Subsequent cancers, mortality, and causes of death in patients with mycosis fungoides and parapsoriasis: a Danish nationwide, population-based cohort study.
BACKGROUND
Data on subsequent cancers, prognostic factors for mortality, and causes of death are limited in mycosis fungoides (MF) and parapsoriasis.


OBJECTIVE
To assess subsequent cancers, mortality, and causes of death in MF and parapsoriasis.


METHODS
Using the Danish nationwide population-based registries, we identified 368 MF patients and 582 parapsoriasis patients and compared them with the general Danish population for subsequent cancers, mortality, and causes of death.


RESULTS
Subsequent cancers were significantly increased in parapsoriasis patients (standardized incidence ratio [SIR], 2.0 [95% confidence interval {CI}, 1.6-2.5]), and a trend was observed in MF (SIR, 1.2 [95% CI, 0.9-1.5]). Mortality was significantly increased in MF (SIR, 2.0 [95% CI, 1.8-2.3]) and parapsoriasis (SIR, 1.3 [95% CI, 1.1-1.5]). Excess mortality from MF was highest during the first 5 years of follow-up, and causes of increased death included both malignant and nonmalignant diseases.


CONCLUSIONS
We have no information regarding clinical stage, treatments, and patient lifestyles.


CONCLUSIONS
Patients with parapsoriasis had a significantly increased risk of subsequent cancers and increased mortality. In addition, the highest excess mortality in the MF group was observed during the first 5 years of follow-up, which suggests that MF exists in both an aggressive and a more indolent form.
Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: lise.lindahl@ki.au.dk.
Lise M
LM
Lindahl
Department of Clinical Epidemiology, Aarhus University Hospital and Research Unit for General Practice, Aarhus University, Aarhus, Denmark.
Morten
M
Fenger-Grøn
Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Lars
L
Iversen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009182:Mycosis Fungoides / Q000401:mortality*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D010267:Parapsoriasis; D011379:Prognosis; D012878:Skin Neoplasms / Q000401:mortality*; D055815:Young Adult
causes of death; cutaneous T-cell lymphoma; mortality; mycosis fungoides; parapsoriasis; subsequent cancers