Does the change on gastrointestinal tract microbiome affects host?
During the past decade, studies on the composition of human microbiota and its relation to the host became one of the most explored subjects of the medical literature. The development of high-throughput molecular technologies allowed a deeper characterization of human microbiota and a better understanding of its relationship with health and disease. Changes in human habits including wide use of antimicrobials can result in dysregulation of host-microbiome homeostasis, with multiple consequences. The purpose of this review is to highlight the most important evidence in the literature of host-microbiome interactions and illustrate how these intriguing relations may lead to new treatment and prevention strategies.
Department of Infectiology, Hospital Heliópolis, São Paulo, SP, Brazil. Electronic address: elisa.m.beirao@gmail.com.
Elisa M
EM
Beirão
Micology Special Laboratory, Disciplina de Infectologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Ana Carolina B
AC
Padovan
Department of Infectiology, Hospital Heliópolis, São Paulo, SP, Brazil.
Juvêncio J D
JJ
Furtado
Micology Special Laboratory, Disciplina de Infectologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Arnaldo L
AL
Colombo
Service of Hospital Infection Control, Disciplina de Infectologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Eduardo A S
EA
Medeiros
D041981:Gastrointestinal Tract / Q000382:microbiology*; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D064307:Microbiota / Q000502:physiology*
Gastrintestinal microbiome; Human