Use of sodium butyrate as an alternative to dietary fiber: effects on the embryonic development and anti-oxidative capacity of rats.
In this study, we evaluated the effect of replacing dietary fiber with sodium butyrate on reproductive performance and antioxidant defense in a high fat diet during pregnancy by using a rat model. Eighty virgin female Sprague Dawley rats were fed one of four diets--(1) control diet (C group), (2) high fat + high fiber diet (HF group), (3) high-fat +5% sodium butyrate diet (SB group), and (4) HF diet + α-cyano-4-hydroxy cinnamic acid (CHC group)--intraperitoneally on days 8, 10, 12, 14, and 16 of gestation. SB and dietary fiber had similar effects on improving fetal number and reducing the abortion rate; however, the anti-oxidant capacity of maternal serum, placenta, and fetus was superior in the HF group than in the SB group. In comparison, CHC injection decreased reproductive performance and antioxidant defense. Both dietary fiber (DF) and SB supplementation had a major but different effect on the expression of anti-oxidant related genes and nutrient transporters genes. In summary, our data indicate that SB and DF showed similar effect on reproductive performance, but SB cannot completely replace the DF towards with respect to redox regulation in high-fat diet; and SB might influence offspring metabolism and health differently to DF.
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
Yan
Y
Lin
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
Zheng-feng
ZF
Fang
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
Lian-qiang
LQ
Che
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
Sheng-yu
SY
Xu
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
De
D
Wu
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
Cai-mei
CM
Wu
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, and Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, Sichuan, P R China.
Xiu-qun
XQ
Wu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001483:Base Sequence; D020148:Butyric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D017931:DNA Primers; D004043:Dietary Fiber / Q000008:administration & dosage*; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D008099:Liver / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D017931:DNA Primers; D004043:Dietary Fiber; D012333:RNA, Messenger; D020148:Butyric Acid