Notching up vascular regeneration.
Regenerative medicine for cardiovascular disease requires effective approaches for therapeutic revascularization. In a recent paper in Cell Research, Sahara et al. establish a new role for Notch signaling to promote endothelial progenitor differentiation, and develop a protocol based on Notch inhibition in endothelial progenitors to markedly enhance the yield and purity of functional endothelial cells differentiated from embryonic stem cells.
Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Bing
B
Zhang
1] Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA [2] Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
William T
WT
Pu
D000818:Animals; D053595:Embryonic Stem Cells / Q000166:cytology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000378:metabolism*; D051880:Receptors, Notch / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*
D051880:Receptors, Notch; D042461:Vascular Endothelial Growth Factor A