Contemporary network proteomics and its requirements.
The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis.
School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, Singapore. gohwils@gmail.com.
Wilson Wen Bin
WW
Goh
School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, Singapore. wongls@comp.nus.edu.sg.
Limsoon
L
Wong
Department of Physiology, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore. judy_sng@sics.a-star.edu.sg.
Judy Chia Ghee
JC
Sng