Dimeric pyrrole-imidazole alkaloids: synthetic approaches and biosynthetic hypotheses.
The pyrrole-imidazole alkaloids are a group of structurally unique and biologically interesting marine sponge metabolites. Among them, the cyclic dimers have caught synthetic chemists' attention particularly. Numerous synthetic strategies have been developed and various biosynthetic hypotheses have been proposed for these fascinating natural products. We discuss herein the synthetic approaches and the biosynthetic insights obtained from these studies.
Division of Chemistry, Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA. Chuo.Chen@UTSouthwestern.edu.
Xiao
X
Wang
Zhiqiang
Z
Ma
Xiaolei
X
Wang
Saptarshi
S
De
Yuyong
Y
Ma
Chuo
C
Chen
D000470:Alkaloids / Q000096:biosynthesis* / Q000138:chemical synthesis*; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis*
D000470:Alkaloids; D001688:Biological Products; D007093:Imidazoles; D011758:Pyrroles