Remission of disseminated cancer after systemic oncolytic virotherapy.
MV-NIS is an engineered measles virus that is selectively destructive to myeloma plasma cells and can be monitored by noninvasive radioiodine imaging of NIS gene expression. Two measles-seronegative patients with relapsing drug-refractory myeloma and multiple glucose-avid plasmacytomas were treated by intravenous infusion of 10(11) TCID50 (50% tissue culture infectious dose) infectious units of MV-NIS. Both patients responded to therapy with M protein reduction and resolution of bone marrow plasmacytosis. Further, one patient experienced durable complete remission at all disease sites. Tumor targeting was clearly documented by NIS-mediated radioiodine uptake in virus-infected plasmacytomas. Toxicities resolved within the first week after therapy. Oncolytic viruses offer a promising new modality for the targeted infection and destruction of disseminated cancer.
Department of Molecular Medicine, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN.
Stephen J
SJ
Russell
Department of Molecular Medicine, Mayo Clinic, Rochester, MN.
Mark J
MJ
Federspiel
Department of Molecular Medicine, Mayo Clinic, Rochester, MN.
Kah-Whye
KW
Peng
Department of Molecular Medicine, Mayo Clinic, Rochester, MN.
Caili
C
Tong
Department of Molecular Medicine, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN.
David
D
Dingli
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
William G
WG
Morice
Department of Radiology, Mayo Clinic, Rochester, MN.
Val
V
Lowe
Department of Radiology, Mayo Clinic, Rochester, MN.
Michael K
MK
O'Connor
Division of Hematology, Mayo Clinic, Rochester, MN.
Robert A
RA
Kyle
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Nelson
N
Leung
Division of Hematology, Mayo Clinic, Rochester, MN.
Francis K
FK
Buadi
Division of Hematology, Mayo Clinic, Rochester, MN.
S Vincent
SV
Rajkumar
Division of Hematology, Mayo Clinic, Rochester, MN.
Morie A
MA
Gertz
Division of Hematology, Mayo Clinic, Rochester, MN.
Martha Q
MQ
Lacy
Department of Molecular Medicine, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address: Dispenzieri.angela@mayo.edu.
Angela
A
Dispenzieri
D000368:Aged; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008459:Measles virus; D008875:Middle Aged; D009101:Multiple Myeloma / Q000000981:diagnostic imaging / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D050504:Oncolytic Viruses; D011877:Radionuclide Imaging