Prostate cancer vaccines in combination with additional treatment modalities.
Immunotherapy has been investigated in both preclinical studies and clinical trials as a new therapy for prostate cancer. Vaccines, including those that utilize dendritic cells, viruses, or DNA, immunize against prostate-specific antigen and prostatic acid phosphatase. The vaccines have long been studied as monotherapy for the cancer, but increasingly more trials have been initiated in combination with other modalities. These include radiation, chemotherapy, and androgen deprivation therapy. This review describes and discusses the various combinations of vaccine immunotherapies.
Department of Urology, University of Iowa, 375 Newton Road, Iowa City, IA, 52242, USA.
Matthew A
MA
Uhlman
Megan T
MT
Bing
David M
DM
Lubaroff
D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D011173:Portraits as Topic; D011471:Prostatic Neoplasms / Q000628:therapy*
D019496:Cancer Vaccines