Postprandial glycaemia and inhibition of α-glucosidase activity by aqueous extract from Coriandrum sativum.
The antihyperglycaemic properties of the aqueous extract from the leaves and stems of Coriandrum sativum L. were evaluated in normoglycaemic rats, and on α-glucosidase activity from Saccharomyces cerevisiae, in order to validate its use in folk medicine. In in vivo experiments rats were administered with the aqueous extract of the plant at 100, 300 and 500 mg/kg, to observe the effect on oral sucrose tolerance test. The aqueous extract exhibited significant antihyperglycaemic activity at the three tested doses. In vitro experiments with α-glucosidase exhibited a competitive-type inhibition. These results confirm the antidiabetic properties of the extract of C. sativum L., probably by the inhibition of α-glucosidase in the gastrointestinal tract.
a Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México , Avenida de los Barrios 1, Col. Los Reyes Iztacala, Tlalnepantla , México 54090 , México.
F
F
Brindis
M
M
González-Andrade
M E
ME
González-Trujano
S
S
Estrada-Soto
R
R
Villalobos-Molina
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D028526:Coriandrum / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D012431:Rutin / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D000520:alpha-Glucosidases / Q000187:drug effects*
D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D012431:Rutin; D000520:alpha-Glucosidases
Coriandrum sativum; antihyperglycaemic; diabetes; α-glucosidase inhibition