Isotonic intravenous maintenance fluid reduces hospital acquired hyponatremia in young children with central nervous system infections.
OBJECTIVE
To find the appropriate type of intravenous fluid (isotonic vs. hypotonic saline in 5 % dextrose) for empiric maintenance fluid therapy in children with central nervous system (CNS) infections that reduces the incidence of hospital acquired hyponatremia.


METHODS
This blinded randomized controlled trial included hospitalized children aged 3 mo to 5 y with suspected CNS infections requiring intravenous maintenance fluid for at least 24 h. The subjects were randomized to receive 0.9 % saline (Group-A), 0.45 % saline (Group-B) and 0.18 % saline (Group-C) at standard maintenance rate. The outcome measures were proportion of patients developing hyponatremia (serum sodium < 135 mmol/L) after 24 h and serum sodium values at 6, 12, 18, 24 h of receiving maintenance fluids.


RESULTS
Of the 92 patients enrolled, 31, 30 and 31 patients were randomized to Group A, B and C, respectively. Majority (60.7 %) of the patients in Group-C developed hyponatremia compared with 7.1 % of the children in Group-A and 46.1 % in Group-B. During first 24 h of fluid administration successive fall in the serum sodium values was observed in patients receiving hypotonic fluids. The risk of developing hyponatremia was nearly 6½ (95 % confidence interval (CI) 1.6-26) to 8.5 (95 % CI 2.16-33.39) times more in patients who received hypotonic saline compared to those who received isotonic saline.


CONCLUSIONS
Administration of 0.9 % saline in 5 % dextrose as intravenous maintenance fluid in children with CNS infection leads to significantly less incidence of hyponatremia when compared to that with hypotonic fluids.
Department of Pediatrics, Lady Hardinge Medical College, and Kalawati Saran Children's Hospital, New Delhi, 110001, India, harishpemde@gmail.com.
Harish K
HK
Pemde
Ashok K
AK
Dutta
Ravitanaya
R
Sodani
Kirtisudha
K
Mishra
D002494:Central Nervous System Infections / Q000628:therapy*; D002675:Child, Preschool; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D007038:Hypotonic Solutions / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D007223:Infant; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D008297:Male; D012964:Sodium / Q000097:blood*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D016896:Treatment Outcome
D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D012965:Sodium Chloride; D012964:Sodium