Two human cases of Diphyllobothrium nihonkaiense infection in Korea.
Diphyllobothrium latum and Diphyllobothrium nihonkaiense are the 2 reported main causes of human diphyllobothriasis in the Republic of Korea. However, the differentiation of these 2 species based on morphologic features alone is difficult. The authors used nucleotide sequencing of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene to diagnose Diphyllobothrium spp. Two patients visited the emergency room at Kyungpook National University Hospital on 3 April and 12 April 2013, respectively, with fragments of parasites found while defecating. The parasites were identified as Diphyllobothrium spp. based on morphologic characteristics, and subsequent cox1 gene sequencing showed 99.9% similarity (1,478/1,480 bp) with D. nihonkaiense. Our findings support the hypothesis that D. nihonkaiense is a dominant species in Korea.
Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Su-Min
SM
Song
Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Hye-Won
HW
Yang
Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Min Kyu
MK
Jung
Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Jun
J
Heo
Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Chang Min
CM
Cho
Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Youn-Kyoung
YK
Goo
Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Yeonchul
Y
Hong
Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Dong-Il
DI
Chung
D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D001483:Base Sequence; D018509:DNA, Helminth / Q000235:genetics*; D004169:Diphyllobothriasis / Q000175:diagnosis* / Q000188:drug therapy; D004170:Diphyllobothrium / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology; D010802:Phylogeny; D011223:Praziquantel / Q000627:therapeutic use; D056910:Republic of Korea; D017422:Sequence Analysis, DNA; D055815:Young Adult
D000871:Anthelmintics; D018509:DNA, Helminth; D011223:Praziquantel; D003576:Electron Transport Complex IV
Diphyllobothrium nihonkaiense; cox1 gene; human case; praziquantel