The variability of atlas-based targets in relation to surrounding major fibre tracts in thalamic deep brain stimulation.
BACKGROUND
In essential tremor (ET), the main target for deep brain stimulation (DBS) is the thalamic ventralis intermedius nucleus (Vim). This target cannot be identified on conventional magnetic resonance imaging (MRI). Therefore, targeting depends on probabilistic coordinates derived from stereotactic atlases. The goal of our study was to investigate the variability of atlas-based Vim targets in relation to surrounding major fibre tracts.


METHODS
With the MRI and computed tomography (CT) scan data of ten patients who underwent DBS, we planned atlas based Vim targets in both hemispheres. We also performed deterministic fibre-tracking with diffusion tensor imaging (DTI) of the dentato-rubro-thalamic tract (DRTT), pyramidal tract (PT) and lemniscus medialis (LM) in all 20 hemispheres. Subsequently, we measured the distance from the atlas-based Vim target to each tract along the medial/lateral (x-coordinate), anterior/posterior (y-coordinate) and superior/inferior axis (z-coordinate).


RESULTS
Seventeen out of 20 DRTTs could be depicted with our standardised DTI/fibre-tracking parameters. The PT and the LM could be displayed in all 20 hemispheres. The atlas-based Vim target was found inside the DRTT in 11 (concerning the x-coordinate) and 10 hemispheres (concerning the z-coordinate). Regarding the anterior/posterior direction, the target was posterior to the DRTT in 11 cases. In 19 hemispheres the Vim target was located medial and superior to the PT and in 17 hemispheres posterior to it. Concerning the LM, the Vim target was found inside the LM in 16 (regarding the x-coordinate) and in 14 cases (regarding the z-coordinate). In eight cases it was located inside and in 12 cases anterior to the LM concerning the y-coordinate.


CONCLUSIONS
We found a considerable variability of the location of atlas-based target points of the ventralis intermedius nucleus in relation to neighbouring major fibre tracts in individual patients. These results suggest that individualised targeting to structures not directly visible on conventional MRI is necessary.
Department of Neurosurgery, University Hospital of Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany, Judith.anthofer@ukr.de.
Judith
J
Anthofer
Kathrin
K
Steib
Claudia
C
Fellner
Max
M
Lange
Alexander
A
Brawanski
Juergen
J
Schlaier
D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D046690:Deep Brain Stimulation / Q000379:methods*; D056324:Diffusion Tensor Imaging; D020821:Dystonic Disorders / Q000601:surgery / Q000628:therapy; D020329:Essential Tremor / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007206:Individuality; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery / Q000628:therapy; D011712:Pyramidal Tracts / Q000601:surgery*; D012189:Retrospective Studies; D013788:Thalamus / Q000601:surgery*; D020651:Ventral Thalamic Nuclei / Q000601:surgery