Click chemistry inspired synthesis of morpholine-fused triazoles.
The synthesis of triazolyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by click reaction with alkynes, and subsequent azidation of chlorohydroxy triazoles was achieved under a one-pot methodology. The developed triazolyl azido alcohols were further utilized for the synthesis of a diverse range of morpholine-fused triazoles of chemotherapeutic value. The structure of all developed compounds has been elucidated using IR, NMR, MS, and elemental analysis, where four of them have been characterized by single-crystal X-ray analysis.
Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University , Varanasi-221005, India.
Kunj B
KB
Mishra
Vinod K
VK
Tiwari
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D057930:Click Chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D004811:Epichlorohydrin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D009025:Morpholines; D014230:Triazoles; D004811:Epichlorohydrin; C037574:morpholine