Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes.
Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps). Our previous study showed that TCs are distinct from fibroblasts (Fbs) and mesenchymal stem cells (MSCs) as concerns gene expression and proteomics. The present study explores patterns of mouse TC-specific gene profiles on chromosome 1. We investigated the network of main genes and the potential functional correlations. We compared gene expression profiles of mouse pulmonary TCs, MSCs, Fbs, alveolar type II cells (ATII), airway basal cells (ABCs), proximal airway cells (PACs), CD8(+) T cells from bronchial lymph nodes (T-BL) and CD8(+) T cells from lungs (T-LL). The functional and feature networks were identified and compared by bioinformatics tools. Our data showed that on TC chromosome 1, there are about 25% up-regulated and 70% down-regulated genes (more than onefold) as compared with the other cells respectively. Capn2, Fhl2 and Qsox1 were over-expressed in TCs compared to the other cells, indicating that biological functions of TCs are mainly associated with morphogenesis and local tissue homoeostasis. TCs seem to have important roles in the prevention of tissue inflammation and fibrogenesis development in lung inflammatory diseases and as modulators of immune cell response. In conclusion, TCs are distinct from the other cell types.
Department of Pulmonary Medicine, Fudan University, Zhongshan Hospital, Shanghai Respiratory Research Institute, Shanghai, China; Department of Pulmonary Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Xiaoru
X
Sun
Minghuan
M
Zheng
Miaomiao
M
Zhang
Mengjia
M
Qian
Yonghua
Y
Zheng
Meiyi
M
Li
Dragos
D
Cretoiu
Chengshui
C
Chen
Luonan
L
Chen
Laurentiu M
LM
Popescu
Xiangdong
X
Wang
D056809:Alveolar Epithelial Cells / Q000378:metabolism*; D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics*; D016000:Cluster Analysis; D015536:Down-Regulation / Q000235:genetics; D005347:Fibroblasts / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D056885:Interstitial Cells of Cajal / Q000378:metabolism*; D008168:Lung / Q000166:cytology*; D008214:Lymphocytes / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D008807:Mice, Inbred BALB C; D059467:Transcriptome; D015854:Up-Regulation / Q000235:genetics
airway epithelial cells; alveolar type II cells; chromosome 1; fibroblasts; genes; lung; lymphocytes; mesenchymal stem cells; telocytes