Antifungal bromophenols from marine red alga Symphyocladia latiuscula.
Three new highly brominated polyphenols, 1-3, together with one known bromophenol, 4, were isolated from the EtOH extract of a marine red alga Symphyocladia latiuscula collected from the coast of Qingdao, P. R. China. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. Compounds 3 and 4 showed activities against the Candida albicans with the MIC values of 25 and 12.5 μg/ml, respectively.
School of Ocean Sciences, China University of Geosciences, No. 29 Xueyuan Road, Haidian District, Beijing, 100083, P. R. China, (phone: +86-10-82319124; fax: +86-10-82320065). xuxl@cugb.edu.cn.
Xiuli
X
Xu
Liyuan
L
Yin
Junhai
J
Gao
Lijie
L
Gao
Fuhang
F
Song
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D059808:Polyphenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
D000935:Antifungal Agents; D006842:Hydrocarbons, Brominated; D059808:Polyphenols
Antifungal activity; Candida albicans; Polyphenols, brominated; Symphyocladia latiuscula