Potential association of hyperhomocysteinemia with the progression of IgA nephropathy: a retrospective study.
BACKGROUND
The high blood homocysteine (Hcy) levels found in patients with hyperhomocysteinemia (HHcy) have been implicated in an increased risk of cardiovascular disease morbidity and mortality in end-stage renal disease (ESRD). This study investigated the association of HHcy with progression of IgA nephropathy.


METHODS
We analyzed 108 participants newly diagnosed with IgA nephropathy between August 2005 and August 2007 in the Department of Nephrology, Chinese People's Liberation Army General Hospital. The association between clinicopathological factors and the Hcy levels were analyzed by Logistic regression and those with ESRD risk were analyzed by Cox regression.


RESULTS
Patients were aged (35.71 ± 10.73) years and included 45.71% women and 12.04% patients with HHcy. In multivariate Logistic regression analysis, HHcy was associated with arterial lesions (OR 2.60; 95% CI 1.55 ± 4.34; P < 0.001) even when age, body mass index, estimated glomerular filtration rate, mean arterial pressure, and initial proteinuria were taken into account. Mean follow-up was (67.37 ± 16.21) months. HHcy was also associated with worse ESRD-free survival (HR 4.71; 95% CI 1.45 to 15.31; P = 0.010).


CONCLUSIONS
HHcy is associated with the risk of intrarenal arterial lesions and may be useful for estimating the prognosis of IgA nephropathy.
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China.
Shuwei
S
Duan
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China.
Shuwen
S
Liu
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China.
Xuefeng
X
Sun
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China.
Ying
Y
Zheng
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China.
Linchang
L
Liu
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China.
Feixiang
F
Yao
Department of Nephrology, Chinese People's Liberation Army General Hospital (301 Hospital), Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center of Kidney Diseases (2013BAI09B05), Beijing 100853, China. Email: wujie301@126.com.
Jie
J
Wu
D000328:Adult; D015992:Body Mass Index; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies