Reactivity of autoantibodies against not only erythrocytes but also hepatocytes in sera of mice with malaria.
In order to further examine the reactivity of autoantibodies, mice were infected with a non-lethal strain of Plasmodium yoelii. Parasitemia appeared between days 10 and 21. During this period, hyperglycemia and hypothermia were serially obeserved and this phenomenon resembled stress-associated responses. In parallel with parasitemia, autoantibodies appeared against nucleus and double-stranded DNA in the sera. To examine further the reactivity of autoantibodies against tissues, immunohistochemical staining using sera from mice with or without malaria was conducted. Autoantibodies contained reactivity to erythrocytes in the spleen, bone marrow and peripheral blood, especially against tissues obtained from mice with malaria. In the liver and intestine, autoantibodies reacted with hepatocytes and intestinal epithelial cells, respectively. These results suggested that the reactivity of autoantibodies against erythrocytes and hepatocytes might be associated with the modulation of the disease course in malaria.
Division of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Yasuhiro
Y
Kanda
Division of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan. Electronic address: kawamura@med.niigata-u.ac.jp.
Toshihiko
T
Kawamura
Division of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan; Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Takahiro
T
Kobayashi
Division of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan; Department of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Niigata 950-3198, Japan.
Hiroki
H
Kawamura
Division of Cellular and Molecular Immunology, Center of Molecular Biosciences, University of Ryukyus, Okinawa 903-0213, Japan.
Hisami
H
Watanabe
Division of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Toru
T
Abo
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D022781:Hepatocytes / Q000276:immunology*; D006943:Hyperglycemia; D007035:Hypothermia; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology; D008099:Liver / Q000166:cytology / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018512:Parasitemia / Q000097:blood / Q000276:immunology; D010967:Plasmodium yoelii / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000974:Antibodies, Antinuclear; D000953:Antigens, Protozoan; D001323:Autoantibodies
Autoantibody; Erythrocytes; Hepatocytes; Malaria; Plasmodium yoelii