Recent progress in metabolic signaling pathways regulating aging and life span.
The NIH Summit, Advances in Geroscience: Impact on Health Span and Chronic Disease, discusses several aspects of cellular degeneration that underlie susceptibility to chronic aging-associated diseases, morbidity, and mortality. In particular, the session on Metabolism focuses on the interrelationship between signal transduction, intermediary metabolism, and metabolic products and byproducts that contribute to pathophysiologic phenotypes and detrimental effects that occur during the aging process, thus leading to susceptibility to disease. Although it is well established that many metabolic pathways (ie, oxidative phosphorylation, insulin-stimulated glucose uptake) decline with age, it often remains uncertain if these are a cause or consequence of the aging process. Moreover, the mechanisms accounting for the decline in metabolic function remain enigmatic. Several novel and unexpected concepts are emerging that will help to define the roles of altered metabolic control in the degenerative mechanisms of aging. This brief review summarizes several of the topics to be discussed in the metabolism of aging session (http://www.geron.org/About%20Us/nih-geroscience-summit).
Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina. chris.newgard@duke.edu.
Christopher B
CB
Newgard
Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York.
Jeffrey E
JE
Pessin
D000375:Aging / Q000502:physiology*; D002908:Chronic Disease / Q000453:epidemiology*; D004734:Energy Metabolism / Q000502:physiology*; D014943:Global Health; D006801:Humans; D009017:Morbidity / Q000639:trends; D018384:Oxidative Stress / Q000502:physiology*; D015398:Signal Transduction; D015996:Survival Rate / Q000639:trends
Intermediary metabolism; Metabolic pathways.; Signal transduction