The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese Central European population.
OBJECTIVE
This study was designed to investigate the relationship between 8 selected adipokines (leptin, leptin receptor, adiponectin, agouti-related peptide, omentin, visfatin, adipsin and resistin), dietary composition and anthropometric parameters found in the Central European obese population.


METHODS
A total of 65 unrelated obese Central European Caucasian individuals were recruited for the study. Phenotypic measurements included weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness. Participants completed standardized self-reported 7-day food records. Plasma levels of leptin, leptin receptor, adiponectin, agouti-related peptide (AgRP), resistin, adipsin, omentin and visfatin were examined using ELISA.


RESULTS
Multiple associations (weight, height, percentage of body fat, waist circumference, hip circumference, WHR and sum of skinfold thickness) with the circulation levels of the investigated adipokines were identified. Leptin-Leptin receptor (L-LR) levels were found to correlate with total energy intake and macronutrients while adipsin was found to strongly correlate with multiple adipokines. Furthermore, the L-LR index was found to constitute a more accurate description of the relationship between BMI and body weight than individual measurements and the Ag-LR index was found to strongly correlate with both anthropometric and dietary characteristics.


CONCLUSIONS
Following confirmation on larger population samples and on samples of different ethnicities, the reported adipokine indexes could become a useful tool for estimating nutritional status and predicting the body composition of specific patient groups.
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00 Brno, Czech Republic. Electronic address: jbienert@med.muni.cz.
Julie
J
Bienertová-Vašků
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00 Brno, Czech Republic.
Jan
J
Novák
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00 Brno, Czech Republic.
Filip
F
Zlámal
Department of Preventive Medicine, Faculty of Medicine, Masaryk University, Kamenice 5, Building A21, 625 00 Brno, Czech Republic.
Martin
M
Forejt
Department of Preventive Medicine, Faculty of Medicine, Masaryk University, Kamenice 5, Building A21, 625 00 Brno, Czech Republic.
Soňa
S
Havlenová
Department of Preventive Medicine, Faculty of Medicine, Masaryk University, Kamenice 5, Building A21, 625 00 Brno, Czech Republic.
Aneta
A
Jackowská
Department of Biochemistry, Faculty of Medicine, Masaryk University, Kamenice 5, Building A16, 625 00 Brno, Czech Republic.
Josef
J
Tomandl
Department of Biochemistry, Faculty of Medicine, Masaryk University, Kamenice 5, Building A16, 625 00 Brno, Czech Republic.
Marie
M
Tomandlová
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00 Brno, Czech Republic.
Zbyněk
Z
Šplíchal
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00 Brno, Czech Republic.
Anna
A
Vašků
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D054369:Agouti-Related Protein / Q000097:blood; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D011416:Complement Factor D / Q000032:analysis; D016207:Cytokines / Q000097:blood; D018153:Czech Republic; D004032:Diet / Q000706:statistics & numerical data*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006305:Health Status Indicators; D006801:Humans; D037102:Lectins / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D009752:Nutritional Status; D009765:Obesity / Q000097:blood*; D054411:Receptors, Leptin / Q000097:blood; D052243:Resistin / Q000097:blood
D054392:Adipokines; D052242:Adiponectin; D054369:Agouti-Related Protein; D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D020738:Leptin; D054411:Receptors, Leptin; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase; D011416:Complement Factor D
Adipokine; Correlation; Index; Leptin; Nutrition; Obesity