Non-Helicobacter pylori, non-NSAIDs peptic ulcers: a descriptive study on patients referred to Taleghani hospital with upper gastrointestinal bleeding.
OBJECTIVE
The purpose of the present study was to evaluate the number and proportion of various causes of upper gastrointestinal bleeding and actual numbers of non-NSAID, non-Helicobacter pylori (H.pylori) peptic ulcers seen in endoscopy of these patients.


BACKGROUND
The number and the proportion of patients with non- H.pylori, non-NSAIDs peptic ulcer disease leading to upper gastrointestinal bleeding is believed to be increasing after eradication therapy for H.pylori.


METHODS
Medical records of patients referred to the emergency room of Taleghani hospital from 2010 with a clinical diagnosis of upper gastrointestinal bleeding (hematemesis, coffee ground vomiting and melena) were included in this study. Patients with hematochezia with evidence of a source of bleeding from upper gastrointestinal tract in endoscopy were also included in this study.


RESULTS
In this study, peptic ulcer disease (all kinds of ulcers) was seen in 61 patients which were about 44.85% of abnormalities seen on endoscopy of patients. Among these 61 ulcers, 44 were duodenal ulcer, 22 gastric ulcer (5 patients had the both duodenal and gastric ulcers). Multiple biopsies were taken and be sent to laboratory for Rapid Urease Test and pathological examination. About 65.53% of patients had ulcers associated with H.pylori, 9.83% had peptic ulcer disease associated with NSAIDs and 11.47% of patients had ulcers associated with both H.pylori and consumption of NSAIDs. 13.11% of patients had non-NSAIDs non- H.pylori peptic ulcer disease.


CONCLUSIONS
The results of this study supports the results of other studies that suggest the incidence of H.pylori infection related with duodenal ulcer is common, and that non-H pylori and non-NSAIDs duodenal ulcer is also common.
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hasan
H
Rajabalinia
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi
M
Ghobakhlou
Loghman Hakim Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahriar
S
Nikpour
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza
R
Dabiri
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rasoul
R
Bahriny
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Somayeh Jahani
SJ
Sherafat
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pardis Ketabi
PK
Moghaddam
Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amirhoushang Mohammad
AM
Alizadeh
H.pylori; Nonsteroidal antiflammatory drugs (NSAIDs); Peptic ulcer; Upper gastrointestinal bleeding