Powerful inner/outer controlled multi-target magnetic nanoparticle drug carrier prepared by liquid photo-immobilization.
Nanomagnetic materials offer exciting avenues for advancing cancer therapies. Most researches have focused on efficient delivery of drugs in the body by incorporating various drug molecules onto the surface of nanomagnetic particles. The challenge is how to synthesize low toxic nanocarriers with multi-target drug loading. The cancer cell death mechanisms associated with those nanocarriers remain unclear either. Following the cell biology mechanisms, we develop a liquid photo-immobilization approach to attach doxorubicin, folic acid, tumor necrosis factor-α, and interferon-γ onto the oleic acid molecules coated Fe3O4 magnetic nanoparticles to prepare a kind of novel inner/outer controlled multi-target magnetic nanoparticle drug carrier. In this work, this approach is demonstrated by a variety of structural and biomedical characterizations, addressing the anti-cancer effects in vivo and in vitro on the HeLa, and it is highly efficient and powerful in treating cancer cells in a valuable programmed cell death mechanism for overcoming drug resistance.
Institute for Advanced Materials and School of Life Science, South China Normal University, Guangzhou 510631, China.
Yan-Qing
YQ
Guan
1] Institute for Advanced Materials and School of Life Science, South China Normal University, Guangzhou 510631, China [2].
Zhe
Z
Zheng
Institute for Advanced Materials and School of Life Science, South China Normal University, Guangzhou 510631, China.
Zheng
Z
Huang
Institute for Advanced Materials and School of Life Science, South China Normal University, Guangzhou 510631, China.
Zhibin
Z
Li
1] Institute for Advanced Materials and School of Life Science, South China Normal University, Guangzhou 510631, China [2].
Shuiqin
S
Niu
1] Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, China [2] Institute for Advanced Materials and Laboratory of Quantum Engineering and Quantum Materials, South China Normal University, Guangzhou 510631, China.
Jun-Ming
JM
Liu
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015153:Blotting, Western; D059447:Cell Cycle Checkpoints / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006397:Hematinics / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000737:chemistry / Q000494:pharmacology; D008027:Light; D058185:Magnetite Nanoparticles; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D019301:Oleic Acid / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D014408:Biomarkers, Tumor; D004337:Drug Carriers; D006397:Hematinics; D058185:Magnetite Nanoparticles; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D019301:Oleic Acid; D004317:Doxorubicin; D007371:Interferon-gamma; D005492:Folic Acid