Management of calcium channel antagonist overdose with hyperinsulinemia-euglycemia therapy: case series and review of the literature.
Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use.
Department of Internal Medicine and Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Route 0354, Gaveston, TX 77555, USA.
Shiwan K
SK
Shah
Department of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USA.
Sanjeev Kumar
SK
Goswami
Department of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USA.
Rajesh V
RV
Babu
Department of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USA.
Gulshan
G
Sharma
Department of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USA.
Alexander G
AG
Duarte