[Preliminary relationship between serum cystatin C level and Parkinson's disease].
OBJECTIVE
To explore the role of serum cystatin C level in Parkinson's disease (PD) and evaluate the relationship between cystatin C level and clinical characteristics and different stages of PD.


METHODS
A total of 115 PD patients and 110 healthy controls were recruited. The results of such routine laboratory tests as triglyceride, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), creatinine, urea, uric acid and cystatin C were assessed from fasting blood samples at our clinical laboratory center. They were further divided into subgroups according to Hoehn & Yahr (H&Y) staging. Statistical analysis was performed with SPSS version 17.0 software.


RESULTS
Compared to controls (0.96 ± 0.16 mg/L), the mean serum level of cystatin C was significantly higher in PD patients (1.06 ± 0.20 mg/L). Spearman's correlation analyses showed a positive and significant correlation between cystatin C levels and age as well as creatinine levels. Correlation was not found between cystatin C level and triglyceride, cholesterol, LDL, HDL, urea or uric acid. ANOVA analysis showed that cystatin C had a higher level during the middle and late stages of PD than that during the early stage.


CONCLUSIONS
Cystatin C level may play an important role in the progression of PD.
Department of Neurology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
Jinmin
J
Xu
Jing
J
Chen
Chengjie
C
Mao
Yaping
Y
Yang
Email: liucf@suda.edu.cn.
Chunfeng
C
Liu
D000368:Aged; D016022:Case-Control Studies; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D044967:Serum / Q000378:metabolism
D055316:Cystatin C