Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer.
OBJECTIVE
In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate.


BACKGROUND
Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study.


METHODS
MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed.


RESULTS
The two bands at around 2800-2900 cm(-1) which are seen in functionalized product are attributed to the CH stretching of MWNT-COOH defects.


CONCLUSIONS
Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.
Proteomics Research Center, Faculty of Paramedical sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran.
Saeed
S
Heidari-Keshel
Department of Chemistry, Islamic Azad University, Shahre-Qods Branch, Shahre-Qods, Iran.
Mahdieh
M
Entezari
Proteomics Research Center, Faculty of Paramedical sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran.
Mostafa
M
Rezaei-Tavirani
Proteomics Research Center, Faculty of Paramedical sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran.
Maryam
M
Ebrahimi
Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Majid
M
Rezaei-Tavirani
Anti cancer; Functionalization; MTT; One-pot reaction