The α5GABAA receptor modulates the induction of long-term potentiation at ventral but not dorsal CA1 hippocampal synapses.
The hippocampal synapses display conspicuous ability for long-term plasticity which is thought to underlie learning and memory. Growing evidence shows that this ability differs along the long axis of the hippocampus, with the ventral CA1 hippocampal synapses displaying remarkably lower ability for long-term potentiation (LTP) compared with their dorsal counterpart when activated with high-frequency stimulation. Here, we show that low frequency, 10 Hz stimulation induced LTP more reliably in dorsal than in ventral CA1 field. Blockade of alpha5 subunit-containing GABAA receptors eliminated the difference between dorsal and ventral hippocampus. We propose that α5GABAA receptor-mediated activity plays a crucial role in regulating the threshold for induction of LTP especially at the ventral CA1 hippocampal synapses. This might have important implications for the functional specialization along the hippocampus.
Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Patras, 26504, Rion, Patras, Greece.
Hermes
H
Pofantis
Costas
C
Papatheodoropoulos
D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008839:Microelectrodes; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D046509:Tissue Culture Techniques
D058787:GABA-A Receptor Antagonists; C511535:Gabra5 protein, rat; D007093:Imidazoles; C105490:L 655,708; D011963:Receptors, GABA-A
GABA; L-655,708; electrophysiology; in vitro; memory; septotemporal; slice; synaptic plasticity; synaptic transmission; α5 subunit