Daphnane-type diterpenoid glucosides and further constituents of Euphorbia pilosa.
Phytochemical investigation of whole plants of Euphorbia pilosa led to the isolation and identification of two new daphnane-diterpenoid glucosides, euphopilosides A and B (1 and 2, resp.), and a new ent-abietane, euphopilolide (3), together with eight known compounds. Compounds 1 and 2 are the first daphnane-type diterpenoid glycosides. Their structures were elucidated by a combination of 1D- and 2D-NMR, and MS analyses, and acid hydrolysis. Compounds 1-9 were evaluated for their in vitro cytotoxicities against five human tumor cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compound 7 showed moderate inhibitory activity against all five cell lines.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China, (phone: +86-871-65223246; fax: +86-871-65223245); College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
Xu-Dong
XD
Zhang
Wei
W
Ni
Huan
H
Yan
Gen-Tao
GT
Li
Hui-Min
HM
Zhong
Yan
Y
Li
Hai-Yang
HY
Liu
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005960:Glucosides; C011309:mezerein
Cytotoxic activity; Daphnane; Diterpenoids; Euphorbia pilosa; Glycosides