Meroterpenoids from the alga-derived fungi Penicillium thomii Maire and Penicillium lividum Westling.
Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-β-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russian Federation.
Olesya I
OI
Zhuravleva
Maria P
MP
Sobolevskaya
Elena V
EV
Leshchenko
Natalya N
NN
Kirichuk
Vladimir A
VA
Denisenko
Pavel S
PS
Dmitrenok
Sergey A
SA
Dyshlovoy
Alexander M
AM
Zakharenko
Natalya Yu
NY
Kim
Shamil Sh
SSh
Afiyatullov
D000818:Animals; D001230:Aspergillus / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D007564:Japan; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010407:Penicillium / Q000737:chemistry*; D044647:Sargassum / Q000382:microbiology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018808:Transcription Factor AP-1 / Q000187:drug effects
D013729:Terpenes; D018808:Transcription Factor AP-1