Evaluation of the applicability of Resovist in DSC-MR perfusion-weighted imaging of rat hyperacute cerebral infarction.
OBJECTIVE
The aim of this study was to evaluate the use of Resovist in perfusion-weighted imaging (PWI) of rat hyperacute cerebral infarction.


METHODS
30 Wistar rats were randomly divided into 2 groups. Group A was intravenously injected with 8 μmol Fe/kg body weight of Resovist, whilst Group B was injected with 0.2 mmol/kg body weight of Gd-DTPA. These dosages were chosen to provide comparable maximum signal changes in normally perfused brain. CBV, CBF and MTT parameter profiles were obtained for the core diseased region and the penumbra of brain ischemia and compared between the two groups. These results were then correlated with pathological findings and TTC staining.


RESULTS
In our rat stroke model, signal-time curves were similar between Gd-DTPA and Resovist, both in the core area with severe ischemia and in the penumbra area with moderate ischemia. The CBV, MTT, and TTP values of PWI for ischemic penumbra in Groups A and B showed no statistical disparity.


CONCLUSIONS
The efficacy of Resovist in MR PWI is similar to Gd-DTPA in the diagnosis of perfusion reduction in the rat stroke model.
Guangdong Academy of Medical Sciences/Guangdong General Hospital, Department of Radiology, Guangdong Prov., P. R. China.
Shui-Xing
SX
Zhang
Wen-Bo
WB
Chen
Chang-Hong
CH
Liang
Biao
B
Huang
D000818:Animals; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D003911:Dextrans / Q000008:administration & dosage; D004195:Disease Models, Animal; D019786:Gadolinium DTPA / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C065507:ferumoxides; D019786:Gadolinium DTPA