Cellular senescence and the senescent secretory phenotype in age-related chronic diseases.
OBJECTIVE
Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered.


RESULTS
A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging.


CONCLUSIONS
Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
Yi
Y
Zhu
Jacqueline L
JL
Armstrong
Tamara
T
Tchkonia
James L
JL
Kirkland
D000375:Aging; D000544:Alzheimer Disease / Q000503:physiopathology; D050197:Atherosclerosis / Q000503:physiopathology; D016922:Cellular Senescence; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007249:Inflammation / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology; D010003:Osteoarthritis / Q000503:physiopathology; D010641:Phenotype