Cardiovascular abnormalities with single dose of tapentadol.
This case represents the development of dizziness, palpitation, tightness in chest, flushing, and tremor on consumption of a single dose of tapentadol (100 mg) for acute lower back pain. The patient was admitted in the intensive cardiac care unit for continuous monitoring. At admission, electrocardiogram showed tachycardia (140/min) along with ST segment elevation in second chest lead (V2). The patient was monitored and advised not to take further doses of tapentadol. He was discharged after 36 hours of admission. Tapentadol should be used cautiously in patients with cardiovascular diseases and receiving sympathomimetic drugs.
A
A
Vachhani
M
M
Barvaliya
V
V
Naik
Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
C B
CB
Tripathi
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D053840:Brugada Syndrome; D000075224:Cardiac Conduction System Disease; D018376:Cardiovascular Abnormalities / Q000139:chemically induced*; D064420:Drug-Related Side Effects and Adverse Reactions; D004562:Electrocardiography; D006329:Heart Conduction System / Q000002:abnormalities; D006801:Humans; D017116:Low Back Pain / Q000150:complications / Q000188:drug therapy*; D008297:Male; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects*; D000077432:Tapentadol; D016896:Treatment Outcome; D055815:Young Adult
D000701:Analgesics, Opioid; D010636:Phenols; D000077432:Tapentadol