Serum insulin-like growth factor-binding protein-3 level correlated with glycemic control and lipid profiles in children and adolescents with type 1 diabetes.
Increasing evidence suggests a role of the IGF axis in the maintenance of normal glucose and lipid metabolism. The local IGF-IGFBP environment changes significantly in response to the diabetes milieu. We aimed at determining serum IGF-1 and IGFBP-3 levels in children with type 1 diabetes mellitus (T1DM) and their relationship with clinical variables. Seventy-eight patients with T1DM and 47 healthy control subjects were included in this study. Significant reduction for concentration of serum IGF-1 was observed in patients with T1DM compared to healthy controls. However, serum IGFBP-3 levels were similar in patients with T1DM compared to controls. Both serum IGF-1 and IGFBP-3 levels were significantly correlated with age, BMI, and serum c-peptide levels. In addition, serum IGFBP-3 levels showed significant positive correlation with HbA1c, total cholesterol, and LDL-cholesterol in the uncontrolled diabetic patients. These findings suggest that IGFBP-3 may be involved in the glucose control and lipid metabolism in those with uncontrolled T1DM. Further studies are needed to document their roles on glucose and lipid metabolism in T1DM.
Min Sun
MS
Kim
Dae-Yeol
DY
Lee
D000293:Adolescent; D001786:Blood Glucose; D002096:C-Peptide / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood*; D008297:Male
D001786:Blood Glucose; D002096:C-Peptide; D007004:Hypoglycemic Agents; D018972:Insulin-Like Growth Factor Binding Protein 3; D008055:Lipids; D007334:Insulin-Like Growth Factor I