Age-related features of Cytoflavin effectiveness during experimental myocardial ischemia.
Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted the energy reserves of cells in old rats with myocardial ischemia.
Belgorod State National Research University, Belgorod, Russia.
N I
NI
Zhernakova
T V
TV
Gorbach
O V
OV
Romashchenko
V V
VV
Rumbesht
D000255:Adenosine Triphosphate / Q000097:blood* / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D004789:Enzyme Activation / Q000187:drug effects; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000166:cytology; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D009536:Niacinamide / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D000255:Adenosine Triphosphate