Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release.
The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N'-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.
IMBIV-CONICET, Departamento de Química Orgánica, ‡UNITEFA-CONICET, Departamento de Farmacia, §CIBICI-CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Haya de la Torre y Medina Allende, Edificio de Ciencias II, Ciudad Universitaria, Córdoba X5000HUA, Argentina.
Julio César
JC
Cuggino
Cintia Belén
CB
Contreras
Alvaro
A
Jimenez-Kairuz
Belkys Angélica
BA
Maletto
Cecilia Inés
CI
Alvarez Igarzabal
D000178:Acrylamides / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015242:Ofloxacin / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry
D000178:Acrylamides; D000179:Acrylates; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D020100:Hydrogels; D011108:Polymers; D012997:Solvents; D014867:Water; D015242:Ofloxacin; C067295:N-isopropylacrylamide; C036658:acrylic acid