Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: report of 2 cases.
BACKGROUND
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low-grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive behavior.


METHODS
We reviewed available records of patients with delayed cervical lymph node metastases from HCCC.


RESULTS
Two patients who were treated with wide local resection for HCCC and remained disease-free at the primary site were diagnosed with cervical lymph node metastases 10 and 14 years later. We treated both with neck dissection, and 1 patient received adjuvant radiation therapy.


CONCLUSIONS
These cases illustrate the risk for occult nodal metastases from HCCC with delayed presentation. Clinician awareness of the presence of subclinical metastases in the neck requires thorough long-term surveillance and potential intervention should nodal disease become manifest.
Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York; Department of Otolaryngology - Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York.
Henry K
HK
Su
Beverly Y
BY
Wang
Abul Ala Syed Rifat
AA
Mannan
Eliza H
EH
Dewey
Erin H
EH
Alpert
Laura L Dos
LL
Reis
Mark L
ML
Urken
D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D013997:Time Factors
clear cell carcinoma; delayed metastases; hyalinizing; lymph node metastases; salivary gland