DABCO-mediated isocyanide-based multicomponent reaction: synthesis of highly substituted cyclopentenes.
Highly substituted cyclopentenes can be accessed rapidly from isocyanides, aldehydes and malononitrile or ethyl cyanoacetate (AB2C2) using DABCO as a catalyst under solvent-free conditions at 40 °C within 30 min.
State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
Li-Rong
LR
Wen
Ming-Chao
MC
Lan
Wen-Kui
WK
Yuan
Ming
M
Li
D001688:Biological Products / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*
D001688:Biological Products; D003486:Cyanides; D003517:Cyclopentanes; D010879:Piperazines; C007306:triethylenediamine