Targeting cytotoxicity and tubulin polymerization by metal-carbene complexes on a purine tautomer platform.
This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(i) and Hg(ii)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India. sverma@iitk.ac.in.
Shruti
S
Khanna
Batakrishna
B
Jana
Abhijit
A
Saha
Prashant
P
Kurkute
Surajit
S
Ghosh
Sandeep
S
Verma
D000225:Adenine / Q000031:analogs & derivatives / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008628:Mercury / Q000737:chemistry / Q000494:pharmacology*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D058105:Polymerization; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism*; D050257:Tubulin Modulators / Q000737:chemistry / Q000494:pharmacology*
D056831:Coordination Complexes; D014404:Tubulin; D050257:Tubulin Modulators; C030011:carbene; D012834:Silver; D008628:Mercury; D000225:Adenine; D008697:Methane