Evaluation of homocysteine levels in patients with polycystic ovarian syndrome.
BACKGROUND
To determine the level of plasma homocysteine in patients with polycystic ovary syndrome (PCOS) compared with healthy controls.


METHODS
In this prospective case-control study on 85 PCOS women and 83 controls matched by body mass index (BMI), homocysteine levels were assessed.


RESULTS
The mean level of homocysteine was 16.25 ± 11.94 μmol/L in patients with PCOS and 11.58 ± 3.82 μmol/L in controls (p=0.002). Patients with PCOS had a significantly higher risk for hyperhomocysteinemia compared with BMI-matched control women.


CONCLUSIONS
These data suggest that homocysteine levels are elevated in the PCOS population. Further studies are needed to characterize this relationship.
Department of Obstetric and Gynecology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University (Mc.S), Tehran, Iran.
Saghar
S
Salehpour
Department of Obstetric and Gynecology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University (Mc.S), Tehran, Iran.
Ozra
O
Manzor-Al-Ajdad
Department of Obstetric and Gynecology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University (Mc.S), Tehran, Iran.
Elham Neisani
EN
Samani
Department of Obstetric and Gynecology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University (Mc.S), Tehran, Iran.
Alireza
A
Abadi
Cardiovascular Disease; Homocysteine Blood; Polycystic Ovary Syndrome