Glutamine-supplemented parenteral nutrition and probiotics in four adult autoimmune enteropathy patients.
To evaluate the effects of glutamine-supplemented parenteral nutrition (PN) and probiotics in adult autoimmune enteropathy (AIE) patients. Four adult AIE patients were identified from April 2006 to January 2012. Clinical and nutritional data were obtained from the patients' medical records. Glutamine-supplemented PN started immediately when the AIE diagnosis was confirmed. The total PN duration was 351 days. According to the PN prescription, the average caloric intake ranged from 20 to 25 kcal/kg/day, and the protein intake ranged from 1.2 to 1.5 g/kg/day. Alanyl-glutamine (20 g/day) was administered to AIE patients for 4 weeks followed by a 2-week break, and this treatment schedule was repeated when PN lasted for more than 6 weeks. Body weight gain and an increased serum albumin level were achieved after PN, and defecation frequency and quality also improved. Each patient received oral supplements, 250 mL of Ensure and two probiotics capsules (each capsule containing 0.5×108 colonies) three times a day when enteral nutrition started. Three AIE patients were successfully weaned off PN, and one patient died of pneumonia. Glutamine-supplemented PN and probiotics show promise in managing patients with AIE and related malnutrition.
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Ren Ying
RY
Xu
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Yan Ping
YP
Wan
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi Quan
YQ
Zhou
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li Ping
LP
Lu
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhi Qi
ZQ
Chen
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying Jie
YJ
Wu
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Clinical Nutrition Center, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei
W
Cai
D000328:Adult; D001644:Bifidobacterium; D013293:Enterococcus faecalis; D005260:Female; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D007779:Lactobacillus acidophilus; D007902:Length of Stay; D008297:Male; D044342:Malnutrition / Q000628:therapy; D010288:Parenteral Nutrition / Q000379:methods*; D016884:Polyendocrinopathies, Autoimmune / Q000628:therapy*; D019936:Probiotics / Q000008:administration & dosage*; D055815:Young Adult
D005973:Glutamine
Autoimmune enteropathy; Glutamine; Malnutrition; Parenteral nutrition; Probiotics