Factors associated with basal insulin dose in Japanese children and young adult type 1 diabetics.
Aims/Introduction:  The daily basal insulin doses/body weight and the daily basal insulin doses/total daily insulin doses of Japanese type 1 diabetes mellitus patients are less than those of Western type 1 diabetes mellitus patients. It is known that Western meals are richer in fat than Japanese meals. We speculated that fat intake might be associated with basal insulin dose in type 1 diabetes mellitus patients.


METHODS
Forty-one outpatients with type 1 diabetes mellitus (20 males, 21 females, mean age 15.9) were enrolled. Variables investigated included: gender, SDS-BMI, HbA1c, duration of diabetes, therapy (MDI or CSII), insulin doses and meal contents. Meal contents were recorded for 3 days using a digital camera. Correlation and multiple regression analyses were performed for all subjects and each age group.


RESULTS
The mean daily basal insulin doses/total daily insulin doses was 0.35. In the multiple regression analysis among all subjects, when daily basal insulin doses/body weight was used as a dependent variable, fat energy ratio of the meal was obtained as an entered variable (P = 0.001). This tendency was particularly strong among the patients aged 14 or above (P < 0.001, standardized coefficient β = 0.683).


CONCLUSIONS
In the type 1 diabetes patients who are aged 14 or above, an association between daily basal insulin doses/body weight and fat energy ratio of meal was suggested. This may explain the aforementioned expectation of increased fat intakes making higher basal insulin doses. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00171.x, 2011).
Department of Pediatrics, Osaka City University Graduate School of Medicine.
Tomomi
T
Hashimoto
Department of Pediatrics, Osaka City University Graduate School of Medicine.
Tomoyuki
T
Kawamura
Department of Pediatrics, Osaka City University Graduate School of Medicine.
Yoneo
Y
Kashihara
Department of Pediatrics, Osaka City University Graduate School of Medicine.
Masakazu
M
Hirose
Hug Hug Kids Clinic, Toyonaka, Japan.
Takashi
T
Higashide
Department of Pediatrics, Osaka City University Graduate School of Medicine.
Akitoshi
A
Tsuruhara
Nutrition Dietary Section, Osaka City University, Osaka.
Hiroki
H
Fujimoto
Nutrition Dietary Section, Osaka City University, Osaka.
Kaori
K
Noi
Department of Pediatrics, Osaka City University Graduate School of Medicine.
Haruo
H
Shintaku
Basal insulin; Dietary fats; Type 1 diabetes mellitus