[Association between polymorphism of dopamine β-hydroxylase gene and Parkinson's disease in Uygurs and Hans of Xinjiang].
OBJECTIVE
To explore the relationship between dopamine β-hydroxylase gene polymorphisms and Parkinson's disease (PD) in Uygurs and Hans populations of Xinjiang.


METHODS
The polymorphisms of DBH gene were determined by polymerase chain-reaction restriction fragment length polymorphism (PCR-RFLP) in 239 PD patients (including 100 Uygurs and 141 Hans) and 232 health controls (including 103 Uygurs and 129 Hans).


RESULTS
The genotypic or allelic distribution of DBH gene had significant differences between PD and control groups in both Uygur and Han populations (P < 0.05). The genotypic or allelic frequencies were significantly different between Han PD and control groups (P < 0.05). The genotypic or allelic frequencies in those aged 65 years or above were significantly different from that in others (P < 0.05). There was a significant increase of PD in A2 allele carriers (OR = 1.965, P < 0.05). And the frequencies of A2 allele in female PD patients were higher than those in female controls (P < 0.05) and A2 allele carriers had a significant increase of PD (OR = 1.696, P < 0.05).


CONCLUSIONS
Different between Uygurs and Hans of Xinjiang, DBH5 TaqI polymorphisms may be associated with PD in Hans. A2 allele carriers are often found in females and those aged 65 years or above.
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Yanyun
Y
Li
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China. Email: zxylao@sohu.com.
Xiaoying
X
Zhang
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Xihe
X
Han
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Miao
M
Guo
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Mei
M
Zou
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Linlin
L
Wang
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Yan
Y
Li
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Yan
Y
Xiao
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Wenjing
W
Zeng
Department of Neurology, General Hospital, Xinjiang Production & Construction Corps, Urumqi 830002, China.
Qiuxia
Q
Song
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002681:China; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic
D004299:Dopamine beta-Hydroxylase