Changes in lipid metabolism during Walker 256 tumor growth and the therapeutic effect of hyperthermia.
The dynamics of lipoprotein content during Walker 256 tumor growth in rats was studied. Moderate changes in HDL and LDL were paralleled by significant changes in VLDL level. A 2-fold increase of VLDL in comparison with the intact control was recorded on day 10 of tumor growth. Exposure to total hyperthermia additionally stimulated VLDL synthesis and this parameter increased by 4 times and more in rats with tumors in comparison with controls. This effect of hyperthermia correlated with significant subsequent decrease of rat mortality caused by the lethal effect of the tumor.
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
A V
AV
Efremov
I I
II
Khegai
K V
KV
Molokov
Yu V
YV
Pakhomova
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D006979:Hyperthermia, Induced / Q000379:methods*; D050356:Lipid Metabolism / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D051381:Rats
D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL