Killer cell immunoglobulin-like receptor genotypes and haplotypes with susceptibility to pulmonary tuberculosis infection.
BACKGROUND
Killer cell immunoglobulin-like receptors (KIRs) are expressed on natural killer (NK) cells and T cells and organized in highly polymorphic families. Genetic diversity is an important characteristic of KIR genes. The aim of the study was to investigate the influence of KIR genotypes and halotypes on the risk of pulmonary tuberculosis (PTB).


METHODS
A sequence specific primer polymerase chain reaction (SSP-PCR) was employed to amplify the KIR genes and pseudogenes in 139 pulmonary tuberculosis (PTB) patients and 30 healthy controls. The innovative point of our study was the subdivision of the patient group according to sputum smear test (positive and negative). KIR genotype and haplotype frequencies were compared between the PTB group and the control group by Chi-square test, and p < 0.05 was regarded as statistically significant.


RESULTS
The genotype AH and FZ14 may be associated with the clearance of Mycobacterium. In addition, haplotype B may be the susceptive haplotype that facilitated the clearance of Mycobacterium and haplotype A may be protective haplotype of PTB.


CONCLUSIONS
Therefore, the diversity of genotypes and haplotypes induced an inflammatory reaction that resulted in continuous infection.
Chao
C
Lu
Xue-Li
XL
Bai
Yun-Feng
YF
Deng
Chang-Yin
CY
Wang
Gang
G
Fan
Ya-Juan
YJ
Shen
Yi-Qing
YQ
Liu
Bing-Chang
BC
Zhang
Yue-Ran
YR
Zhao
Cheng
C
Huan
Chun-Zhi
CZ
Zhang
Zhi-Ming
ZM
Lu
D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D054340:Receptors, KIR / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000473:pathology
D054340:Receptors, KIR