Supplementary motor area (SMA) volume is associated with psychotic aberrant motor behaviour of patients with schizophrenia.
We aimed to investigate whether aberrant motor behavior in schizophrenia was associated with structural alterations in the motor system. Whole brain voxel based morphometry of patients with different severity of motor symptoms identified altered gray matter volume in the supplementary motor area (SMA), a key region of the motor system.
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland. Electronic address: stegmayer@puk.unibe.ch.
Katharina
K
Stegmayer
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Helge
H
Horn
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Andrea
A
Federspiel
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Nadja
N
Razavi
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Tobias
T
Bracht
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Karin
K
Laimböck
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Werner
W
Strik
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Thomas
T
Dierks
Support Center of Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, 3010 Bern, Switzerland.
Roland
R
Wiest
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Thomas J
TJ
Müller
University Hospital of Psychiatry, Bolligenstrasse 111, 3060 Bern Switzerland, Switzerland.
Sebastian
S
Walther
D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000473:pathology* / Q000503:physiopathology; D009048:Motor Skills / Q000502:physiology; D011597:Psychomotor Performance; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D012720:Severity of Illness Index
Dimension; Movement disorder; Rating scale