T-cell activation positively correlates with cell-associated HIV-DNA level in viremic patients with primary or chronic HIV-1 infection.
We investigated the relationship between the size of blood HIV reservoirs and T-cell activation in patients with primary HIV infection (PHI) and chronic HIV infection (CHI) before and after antiretroviral therapy (ART) interruption. Levels of T-cell activation strongly positively correlated with HIV-DNA levels in viremic PHI and CHI patients. In ART-treated CHI patients, residual immune activation was not associated with HIV-DNA levels. Interestingly, early levels of HIV-DNA in PHI predicted the extent of residual T-cell proliferation under ART.
aUniversité Paris Descartes, Sorbonne Paris Cité bInstitut Pasteur, Régulation des infections rétrovirales cAP-HP Hôpital Européen Georges Pompidou dUniversité Paris Diderot, Sorbonne Paris Cité eINSERM U943 fUniversité Pierre et Marie Curie gAP-HP Hôpital Saint-Antoine hUniversité Paris Descartes, EA 3620, Paris, France. *Present address: Urology Research Unit, Lausanne University Hospital, Lausanne, Switzerland.
Laurence
L
Weiss
Mathieu F
MF
Chevalier
Lambert
L
Assoumou
Céline
C
Didier
Pierre-Marie
PM
Girard
Christophe
C
Piketty
Dominique
D
Costagliola
Christine
C
Rouzioux
D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008213:Lymphocyte Activation; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000276:immunology*
D004279:DNA, Viral