Acute renal failure associated with albendazole therapy in a patient with trichinosis.
A 72-year-old Caucasian woman presented with a 3-week history of confusion, cramping abdominal pain, nausea, vomiting, diarrhoea, fatigue and dehydration. By history, she reported consumption of raw pork and bacon that was salted and cured in brine, but not boiled or cooked. Laboratory testing was significant for an absolute eosinophil count of 3.09×10(9)/L. She was found to have a positive Trichinella serology by ELISA testing. Based on history of raw pork consumption, symptoms, peripheral eosinophilia and positive serology, a diagnosis of trichinosis was made. Treatment was started with oral albendazole. Following initiation of therapy, the patient developed acute kidney injury presumably secondary to albendazole. Therapy was discontinued. Her serum creatinine returned to baseline over the following days. The decision was made to proceed with observation alone, as she did not tolerate treatment. At the 3-week follow-up, her gastrointestinal symptoms had improved and her eosinophilia had resolved.
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Cassandra Marie
CM
Batzlaff
Department of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Jakrapun
J
Pupaibool
Department of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
M Rizwan
MR
Sohail
D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D015766:Albendazole / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014234:Trichinella / Q000302:isolation & purification*; D014235:Trichinellosis / Q000175:diagnosis / Q000188:drug therapy*
D015766:Albendazole