MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.
Mammalian cells have the ability to recognize virus infection and mount a powerful antiviral transcriptional response that provides an initial barrier to replication and impacts both innate and adaptive immune responses. Retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) proteins mediate intracellular virus recognition and are activated by viral RNA ligands to induce antiviral signal transduction. While the mechanisms of RIG-I regulation are already well understood, less is known about the more enigmatic melanoma differentiation-associated 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2). Emerging evidence suggests that these two RLRs are intimately associated as both accomplices and antagonists of antiviral signal transduction.
Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.
Kenny R
KR
Rodriguez
Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.
Annie M
AM
Bruns
Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA horvath@northwestern.edu.
Curt M
CM
Horvath
D056704:Adaptive Immunity; D000818:Animals; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D000072640:Interferon-Induced Helicase, IFIH1; D020365:RNA Helicases / Q000378:metabolism*; D012328:RNA Viruses / Q000276:immunology*; D015398:Signal Transduction
C520569:DHX58 protein, human; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1; D020365:RNA Helicases