The effect of pharmacy restriction of clindamycin on Clostridium difficile infection rates in an orthopedics ward.
A high consumption of clindamycin was noted in an orthopedics ward with high rates of Clostridium difficile infection (CDI). We restricted clindamycin for the entire ward. A reduction of 88% in CDI (1.07 to 0.12 × 1,000 patients-days, P = .056) and 84% for all-cause diarrhea (2.40 to 0.38 × 1,000 patients-days, P = .021) was achieved. Clindamycin was reduced 92.61% without an increase in other antibiotics. We identified high consumption of clindamycin as a risk factor for CDI.
Coordinación de Epidemiología Hospitalaria, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Nora Cecilia
NC
Cruz-Rodríguez
Coordinación de Epidemiología Hospitalaria, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Raúl
R
Hernández-García
Coordinación de Epidemiología Hospitalaria, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Ana Gabriela
AG
Salinas-Caballero
Subdirección de Asistencia Hospitalaria, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Edelmiro
E
Pérez-Rodríguez
Servicio de Gastroenterología y Departamento de Patología Clínica, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Elvira
E
Garza-González
Coordinación de Epidemiología Hospitalaria, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México; Servicio de Infectología, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México. Electronic address: acamacho_md@yahoo.com.
Adrián
A
Camacho-Ortiz
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage*; D016360:Clostridioides difficile; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D004363:Drug Utilization / Q000706:statistics & numerical data*; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology* / Q000517:prevention & control; D006784:Hospitals, Teaching; D006801:Humans; D009985:Orthopedics; D010607:Pharmacy Service, Hospital; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D002981:Clindamycin
Antibiotic stewardship; Antibiotics; Hospital acquired infection