Retinal vessel oxygen saturation increases after vitrectomy.
OBJECTIVE
To evaluate the effects of vitrectomy on retinal vascular oxygen saturation in an adult population.


METHODS
This was a prospective observational study. Twenty-seven eyes of 27 patients who underwent vitrectomy for macular conditions were included. Retinal oximetry was performed using the Oxymap system prior to vitrectomy and 3 months after surgery and the mean retinal arterial and venous oxygen saturation were measured. The arterial-venous difference (AVD) was calculated as the difference between the arterial and venous saturations. Multivariate linear regression models were constructed to compare oxygen saturation before and after surgery, with adjustments for age, sex, hypertension, hyperlipidemia, diabetes mellitus, and indication for surgery.


RESULTS
The mean age of the subjects was 68.4 ± 8.9 years, 15 (55%) were male and the majority were of Chinese ethnicity (93%). The mean arterial saturation increased significantly after vitrectomy (101.93 ± 8.36% vs. 96.16 ± 14.14%, P = 0.01). The mean venous saturation also increased significantly after surgery (59.76 ± 8.52% vs. 50.40 ± 11.72%, P = 0.02). The mean AVD significantly decreased from 45.76 ± 12.18% before surgery to 42.17 ± 10.94% after surgery (P = 0.02).


CONCLUSIONS
Retinal arterial and venous oxygen saturation are significantly increased after vitrectomy, while the AVD is decreased after vitrectomy.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Laurence Shen
LS
Lim
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Licia
L
Tan
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Duke-NUS Graduate Medical School, Singapore.
Shamira
S
Perera
D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000503:physiopathology / Q000601:surgery; D012171:Retinal Vessels / Q000502:physiology*; D011795:Surveys and Questionnaires; D014821:Vitrectomy
D010100:Oxygen
oximetry; retinal ischemia; retinal vessel; vitrectomy