Evaluation of salivary beta-2 microglobulin as HBV proliferation marker in HBS Ag(+), HBV DNA PCR(+) and HBV DNA PCR(-) subjects.
OBJECTIVE
The aim of this study was to determine the concentration of salivary B2M as a marker of viral proliferation in HBS Ag(+), HBV DNA PCR(+) and Hbs Ag(+) and HBV DNA PCR(-) subjects.


BACKGROUND
Beta-2 microglobulin (B2M) is responsible for transmission of viral antigens such as Hepatitis B (HBV) on the surface of liver cells as part of an HLA complex.


METHODS
In this case control study, 25 PCR(+) and 2 PCR(-) patients were included. 5 mL of the saliva sample was obtained from all patients and salivary B2M level was measured using nephelometer. The data was evaluated by the descriptive, chi square and t tests.


RESULTS
72% of the PCR(+) patients received medications and in contrast, 85.7% of the patients with PCR(-) did not take any medication (P < 0.001). The average salivary concentration ofBeta-2 microglobulin in the PCR(+) group (5.28 ± 5.45 mg/deciliter) was more than PCR(-) group (1.51±0.77) and this difference was statistically significant (P = 0.003).


CONCLUSIONS
The salivary B2Mlevel can be used as a marker of viral proliferation in patients with hepatitis B.
Department of Oral Medicine, School of Dentistry, Dentistry Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Hamidreza
H
Abdolsamadi
Department of Infectious Diseases, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Peiman
P
Eini
Department of Oral Medicine, School of Dentistry, Dentistry Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Negin
N
Ronasi
Department of Gastroenterology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Seyed Alireza
SA
Kaboli
Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Mehrdad
M
Hajilooei
Department of Biostatistics, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Abbas
A
MoghimBeigi
Department of Oral Medicine, School of Dentistry, Dentistry Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Poorandokht
P
Davoudi
Department of Oral Medicine, School of Dentistry, Dentistry Research Center, Hamadan University of Medical Sciences, Hamadan, Iran ; Research Center of Molecular Medicine and Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Fatemeh
F
AhmadiMotemayel
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamid Mohaghegh
HM
Shalmani
Beta-2 microglobulin; Hepatitis B; Saliva; Virus proliferation marker