Meta-analysis of (18) fluorodeoxyglucose positron emission tomography-CT for diagnosis of lung malignancies in patients with head and neck squamous cell carcinomas.
BACKGROUND
The purpose of this meta-analysis was to evaluate the accuracy of (18) fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT for diagnosis of lung malignancies in patients with head and neck squamous cell carcinomas (HNSCCs).


METHODS
A systematic review of relevant literature was performed in the MEDLINE and EMBASE databases. The Stata software was used to pool the sensitivity, specificity, diagnostic odds ratio, and likelihood ratios, and to construct summary receiver operating characteristic (ROC) curves for (18) FDG PET-CT.


RESULTS
Twelve articles (1431 patients) were included in this study. The pooled sensitivity, specificity, diagnostic odds ratio, positive likelihood ratio, and negative likelihood ratio with 95% confidence interval (CI) for (18) FDG PET-CT were 0.85 (95% CI = 0.66-0.94), 0.98 (95% CI = 0.96-0.99), 335 (95% CI = 96.4-1166), 52.0 (95% CI = 23.3-115.9), and 0.16 (95% CI = 0.06-0.43), respectively. Area under the curve was 0.99 (95% CI = 0.97-0.99).


CONCLUSIONS
(18) FDG PET-CT is a valuable diagnostic tool for diagnosing lung malignancies in patients with HNSCC.
Department of Otolaryngology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Kai
K
Xi
Department of Otolaryngology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.|Department of Anesthesiology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Xiaojuan
X
Xie
Department of Otolaryngology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.|Laboratory of Pharmacology and Medical Molecular Biology, Medical College of Henan University of Science and Technology, Luoyang, China.
Shoumin
S
Xi
D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D019788:Fluorodeoxyglucose F18
18fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT; head and neck squamous cell carcinomas; lung metastases; meta-analysis; second primary lung cancers