The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response: a study based on a multicenter database in Korea.
Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the factors associated with the response to medical treatment by using a multicenter database in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative period in surgical patients or as a response to an acute illness was excluded. CPO cases were identified in 15 tertiary referral hospitals between 2000 and 2011. The patients' data were retrospectively reviewed and analyzed. In total, 104 patients (53 men; mean age at diagnosis, 47 yr) were identified. Seventy-seven of 104 patients (74%) showed a transition zone on abdominal computed tomography. Sixty of 104 patients (58%) showed poor responses to medical treatment and underwent surgery at the mean follow-up of 7.4 months (0.5-61 months). Younger age at the time of diagnosis, abdominal distension as a chief complaint, and greater cecal diameter were independently associated with the poor responses to medical treatment. These may be risk factors for a poor response to medical treatment.
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
Kwang Jae
KJ
Lee
Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Kee Wook
KW
Jung
Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Seung-Jae
SJ
Myung
Department of Gastroenterology, Gyeongsang National University School of Medicine, Jinju, Korea.
Hyun Jin
HJ
Kim
Department of Gastroenterology, Seoul National University Bundang Hospital, Seongnam, Korea.
Na Young
NY
Kim
Department of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Young Hoon
YH
Yoon
Department of Gastroenterology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
Chong Il
CI
Sohn
Department of Gastroenterology, Dankook University College of Medicine, Cheonan, Korea.
Jung Eun
JE
Shin
Department of Gastroenterology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Yu Kyung
YK
Cho
Department of Gastroenterology, Soonchunhyang University Hospital, Seoul, Korea.
Soo Jin
SJ
Hong
Department of Gastroenterology, Soonchunhyang University Hospital, Seoul, Korea.
Tae Hee
TH
Lee
Department of Gastroenterology, Keimyung University School of Medicine, Daegu, Korea.
Kyung Sik
KS
Park
Department of Gastroenterology, Ewha Womans University School of Medicine, Seoul, Korea.
Hye-Kyung
HK
Jung
Department of Gastroenterology, Chung-Ang University College of Medicine, Seoul, Korea.
Chang Hwan
CH
Choi
Department of Gastroenterology, Pusan National University School of Medicine, Busan, Korea.
Gwang Ha
GH
Kim
Department of Gastroenterology, Dongguk University Ilsan Hospital, Goyang, Korea.
Jae Hak
JH
Kim
Department of Gastroenterology, Eulji University School of Medicine, Seoul, Korea.
Yoon Ju
YJ
Jo
Department of Gastroenterology, Soonchunhyang University Hospital, Seoul, Korea.
Joon Seong
JS
Lee
Department of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Hyo-Jin
HJ
Park
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003106:Colon / Q000473:pathology* / Q000601:surgery; D003112:Colonic Pseudo-Obstruction / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D003248:Constipation / Q000175:diagnosis; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012189:Retrospective Studies; D064346:Sagittal Abdominal Diameter; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
Abdominal Distension; Colonic Dilatation; Colonic Pseudo-obstruction; Transition Zone