Effects of afala and antiestrogen ICI 182,780 in the model of hormone-dependent prostate inflammation.
In the hormone-dependent prostate inflammation model induced by implantation of slow-releasing pellets (50 mg testosterone and 5 mg estradiol) to Noble male rats, intragastric administration of Afala at a dose of 7.5 ml/kg for 18 weeks reduced the number of inflamed prostatic acini. The effect of afala was comparable with that of antiestrogen ICI 182,780 (3 mg/kg subcutaneously twice a week for 18 weeks). Prolonged treatment with hormones in high doses induced severe inflammation of the prostate tissue, which was not terminated by the test preparations. As differentiated from the antiestrogen ICI 182,780, afala did not induce body weight gain and decrease in pituitary weight in experimental animals in comparison with the control group.
Pharmatest Services Ltd, Turku, Finland, nauka@materiamedica.ru.
J
J
Bernoulli
Y
Y
Konkol
H
H
Vuorikoski
E
E
Yatkin
D000704:Analysis of Variance; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077267:Fulvestrant; D006652:Histological Techniques; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D013739:Testosterone / Q000009:adverse effects; D015430:Weight Gain / Q000187:drug effects
D000906:Antibodies; C533336:afala; D000077267:Fulvestrant; D013739:Testosterone; D004958:Estradiol