[Acquired cutis laxa associated with monoclonal gammopathy and lambda light chain deposition disease].
Cutis laxa is a rare entity characterized clinically by redundant skin that gives an appearance of premature aging. The appearance relates to a loss of elasticity because of the destruction of elastic fibers that affects the skin and other organs. It may be associated with inflammatory conditions or diseases, such as plasma cell dyscrasias. We report the case of a 54-year-old man with acquired cutis laxa, which preceded the development of IgG-lambda monoclonal gammopathy with lambda light chain deposits in the kidney. The patient had a fatal outcome owing to severe and rapidly progressive renal failure. We emphasize the importance of recognizing a plasma cell dyscrasia in a patient with cutis laxa, although this association is rare.
Hospital Clínico Universitario de Valencia.
Antonio J
AJ
Gonzalez-Rodriguez
Rebeca
R
Bella-Navarro
Dolores
D
Ramon Quiles
Esperanza
E
Jorda-Cuevas
D000686:Amyloidosis / Q000175:diagnosis; D003483:Cutis Laxa / Q000150:complications*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000378:metabolism; D051437:Renal Insufficiency / Q000150:complications* / Q000378:metabolism
D007146:Immunoglobulin lambda-Chains