New oral anticoagulants vs vitamin K antagonists: benefits for health-related quality of life in patients with atrial fibrillation.
New oral anticoagulants (NOAC) have demonstrated their efficacy as an alternative to vitamin K antagonists (VKA) in the prophylaxis of cardioembolic events in patients with atrial fibrillation (AF). However, evidence on the benefits of NOAC in health-related quality of life (HRQoL) is lacking.We evaluated changes in HRQoL related to oral anticoagulation therapy employing a specific questionnaire in a cohort of 416 patients with AF undergoing electrical cardioversion. In terms of HRQoL, we observed a progressive adaptation to treatment with VKA; satisfaction with NOAC remained constant. Older age, higher left ventricular ejection fraction and NOAC were associated with better HRQoL.
1. Grup de Recerca Cardiovascular, Hospital Universitari de Sant Joan, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Josep M
JM
Alegret
2. Hospital de la Sta. Creu i St. Pau, Barcelona, Spain.
Xavier
X
Viñolas
3. Hospital Virgen de la Salud, Toledo, Spain.
Miguel A
MA
Arias
4. Hospital Universitari Parc Taulí, Sabadell, Spain.
Antoni
A
Martínez-Rubio
5. LA-SER Outcomes, Oviedo, Spain.
Pablo
P
Rebollo
6. Medical Department, Bayer HealthCare, Barcelona, Spain.
Carles
C
Ràfols
7. Hospital Clínico, Santiago de Compostela, Spain.
José L
JL
Martínez-Sande
D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000473:pathology; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects; D000069604:Dabigatran; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D018487:Ventricular Dysfunction, Left / Q000473:pathology; D014812:Vitamin K / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives
D000925:Anticoagulants; D001562:Benzimidazoles; D015091:beta-Alanine; D014812:Vitamin K; D000069604:Dabigatran
dabigatran; health-related quality of life; new oral anticoagulants; ribaroxaban.; vitamin K antagonists