Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes.
There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsil's lymphoid tissue of patients on highly active antiretroviral therapy (HAART) and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P = 0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.
aService of Infectious Diseases bService of Microbiology, Hospital Universitario San Cecilio, Granada, Spain.
David
D
Vinuesa
Jorge
J
Parra-Ruiz
Natalia
N
Chueca
Marta
M
Alvarez
Leopoldo
L
Muñoz-Medina
Federico
F
Garcia
Jose
J
Hernandez-Quero
D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000821:virology*; D011533:Proviruses / Q000235:genetics; D044967:Serum / Q000821:virology; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
D004279:DNA, Viral; D017320:HIV Protease Inhibitors