Dissolvable metallohydrogels for controlled release: evidence of a kinetic supramolecular gel phase intermediate.
Two metallohydrogels based on an amino acid-based ligand and Zn(II) salts were synthesized. These hydrogels show an uncommon, reversible, time-dependent transformation from the opaque to transparent state. These hydrogels also exhibit gradual dissolution in water (pH ≤ 7) over time. A water-soluble stimulant, caffeine, could be in situ loaded into the hydrogels and slowly released during dissolution.
Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. HomiBhabha Road, Pune 411008, India. r.banerjee@ncl.res.in.
Subhadeep
S
Saha
Jürgen
J
Bachl
Tanay
T
Kundu
David
D
Díaz Díaz
Rahul
R
Banerjee
D000596:Amino Acids / Q000737:chemistry; D002110:Caffeine / Q000008:administration & dosage / Q000737:chemistry; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D004355:Drug Stability; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D012995:Solubility; D015032:Zinc / Q000737:chemistry
D000596:Amino Acids; D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D020100:Hydrogels; D008024:Ligands; D008670:Metals; D002110:Caffeine; D015032:Zinc