Associations of small dense low-density lipoprotein and adiponectin with complications of type 2 diabetes.
BACKGROUND
Small dense low-density lipoprotein (sd-LDL) has been demonstrated to be associated with cardiovascular diseases (CVD). The proposed atherogenic properties of hypoadiponectinemia might be mediated through increased sd-LDL. In this study, the associations of sd-LDL with cardiovascular and other complications of diabetes, and also with plasma levels of adiponectin, were investigated in diabetic patients.


METHODS
173 patients, with documented type 2 diabetes mellitus, were enrolled in this cross-sectional study. Laboratory, anthropometric, and clinical characteristics were all determined. The presence of CVD, hypertention, and microalbuminuria were also evaluated. Homeostasis model assessment of insulin resistance was calculated.


RESULTS
Sd-LDL concentrations were significantly lower in patients with CVD than those without CVD (p = 0.020); and also lower in hypertensive patients relative to non-hypertensive ones (p = 0.008). Serum levels of adiponectin were significantly lower in patients with CVD (p < 0.001), and hypertension (p = 0.002), compared with those without each of these complications. Sd-LDL and adiponectin concentrations were positively correlated (r = 0.36, p < 0.001). Sd-LDL was also significantly associated with HbA1c (r = 0.24, p = 0.002).


CONCLUSIONS
Our data suggest that decreased levels of adiponectin might be associated with developing complications of diabetes. This study did not provide any supportive results for the association of increased sd-LDL concentrations with CVD; neither for its association with other complications of diabetes.
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran.
Alireza
A
Esteghamati
Solmaz
S
Asnafi
Mohammad
M
Eslamian
Sina
S
Noshad
Manouchehr
M
Nakhjavani
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D052242:Adiponectin; D001786:Blood Glucose; D008077:Lipoproteins, LDL
Cardiovascular diseases; LDL particles; diabetic complications; dyslipidemia; lipoprotein particle size; obesity