A novel technique for the measurement of CBF and CBV with robot-arm-mounted flat panel CT in a large-animal model.
OBJECTIVE
Endovascular therapy is an emerging treatment option in patients with acute ischemic stroke and especially in cases presenting late after symptom onset. Information about remaining viable tissue as measured with perfusion imaging is crucial for proper patient selection. The aim of this study was to investigate whether perfusion imaging with C-arm CT in the angiography suite is feasible and provides measurements comparable with ones made by CTP.


METHODS
The MCA was occluded surgically in 6 sheep. Perfusion studies were performed before surgery, immediately after, and at 3 hours after MCA occlusion by using a robotic flat panel detector C-arm angiographic system. For comparison, conventional CTP was performed at the same time points. Two different protocols with the C-arm CT were tested. Images were analyzed by 2 readers with regard to the presence and size of perfusion abnormalities.


RESULTS
With C-arm CT, perfusion abnormalities were detected with a high sensitivity and specificity when vessel occlusion was confirmed by criterion standard DSA. No difference was found between lesions sizes measured with the 2 C-arm CT protocols and CTP. Growth of the CBV lesions with time was captured with C-arm CT and CTP.


CONCLUSIONS
In this small study, it was feasible to qualitatively measure CBV and CBF by using a flat panel detector angiographic system.
From the Institute of Neuroradiology (O.B., C.S., A.L., S.S., M.S.) oliver.beuing@med.ovgu.de.
O
O
Beuing
Healthcare Telematics and Medical Engineering (A.B., S.G., G.R.), Otto von Guericke University, Magdeburg, Germany.
A
A
Boese
Siemens AG (Y.K., Y.D.-Z.), Healthcare Sector, Erlangen, Germany.
Y
Y
Kyriakou
Siemens AG (Y.K., Y.D.-Z.), Healthcare Sector, Erlangen, Germany.
Y
Y
Deuerling-Zengh
Department of Neurosurgery (B.J.).
B
B
Jöllenbeck
From the Institute of Neuroradiology (O.B., C.S., A.L., S.S., M.S.).
C
C
Scherlach
From the Institute of Neuroradiology (O.B., C.S., A.L., S.S., M.S.).
A
A
Lenz
From the Institute of Neuroradiology (O.B., C.S., A.L., S.S., M.S.).
S
S
Serowy
Healthcare Telematics and Medical Engineering (A.B., S.G., G.R.), Otto von Guericke University, Magdeburg, Germany.
S
S
Gugel
Healthcare Telematics and Medical Engineering (A.B., S.G., G.R.), Otto von Guericke University, Magdeburg, Germany.
G
G
Rose
From the Institute of Neuroradiology (O.B., C.S., A.L., S.S., M.S.).
M
M
Skalej
D000818:Animals; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging; D055420:Perfusion Imaging / Q000379:methods*; D012371:Robotics / Q000379:methods*; D012756:Sheep; D020521:Stroke / Q000000981:diagnostic imaging*