Improvement in lipid profile after vitamin D supplementation in indigenous argentine school children.
OBJECTIVE
To determine whether vitamin D supplementation of indigenous school children living at high altitude who are vitamin D insufficient improves lipid profile.


METHODS
A prospective two-year study evaluated 60 children (29 males) from Hogar School who received 100,000 units of vitamin D and 36 children (16 males) from Sosa School who received 50,000 units. Anthropometric measures, Triglycerides (TG), HDL-C, TG/HDL-C, and vitamin D levels were measured in November 2011 and in November 2013.


RESULTS
Children aged 8.8 ± 2 years with mean z-BMI (-0.43) were evaluated. After vitamin D supplementation, mean vitamin D levels increased from 14.7 to 32.1 ng/mL (p < 0.01) in Hogar and from 14.6 to 25.1 ng/mL (p < 0.01) in Sosa School. Furthermore, mean HDL-C increased significantly in Hogar (39.8 to 43.9 mg/dL); while no significant changes were found in Sosa School (44.4 to 45.1 mg/dL). Though no significant changes were found in median TG (117 to 111 mg/dL) and TG/HDL (3.0 to 2.7 mg/dL) in Hogar; TG (95 to 111 mg/dL) and TG/HDL-C (2.2 to 2.4 mg/dL) increased significantly in Sosa School. Several multiple linear regression analyses showed that children from Hogar School decreased TG/HDL-C by 1.3 mg/dL (R(2): 0.14), HDL-c by 3.6 mg/dL (R(2): 0.13), and TG by 31 mg/dL (R(2): 0.11), adjusted for confounding factors.


CONCLUSIONS
Indigenous children who received 100,000 U of vitamin D significantly improved vitamin D and lipid levels compared to children who received 50,000 U, suggesting that optimal vitamin D levels are associated with a healthier lipid profile.
Valeria
V
Hirschler
Gustano
G
Maccallini
Maria I
MI
Tamborenea
Claoudio
C
Gonzalez
Milva
M
Sanchez
Claudia
C
Molinari
Luis
L
Castano
Graciela
G
Colque
Mariana
M
Hidalgo
Universidad de Buenos Aires, Maipu 812 5 M Buenos Aires (1006), Argentina. vhirschler@intramed.net.
Mirta
M
Urzagasti
D001118:Argentina; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D044382:Population Groups; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000188:drug therapy*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C034396:HDL-triglyceride; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014807:Vitamin D