Polymersomes as an effective drug delivery system for glioma--a review.
Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug delivery systems. Among them, polymersomes are superior novel carriers with diverse functions like enhanced stability, low permeability, tunable membrane properties, surface functionality, and long blood circulation time which make them suitable for cancer therapy. These are bilayered vesicles capable of encapsulating both hydrophilic and hydrophobic drugs used to target glioma effectively. In this review, we have discussed on general preparation, characterization, and targeting aspects of surface modified polymersomes for effective delivery of therapeutic agents to glioma.
Department of Pharmaceutics, PSG College of Pharmacy , Peelamedu, Coimbatore, Tamil Nadu , India and.
Balakumar
B
Krishnamoorthy
Vamshikrishna
V
Karanam
Vijaya Raghavan
VR
Chellan
Karthik
K
Siram
Tamil Selvan
TS
Natarajan
Marslin
M
Gregory
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000188:drug therapy*; D004337:Drug Carriers; D004655:Emulsions; D005910:Glioma / Q000188:drug therapy*; D011108:Polymers; D011956:Receptors, Cell Surface / Q000187:drug effects; D012997:Solvents
D000970:Antineoplastic Agents; D004337:Drug Carriers; D004655:Emulsions; D011108:Polymers; D011956:Receptors, Cell Surface; D012997:Solvents
Blood–brain barrier; dual-targeting effect; glioma; polymersomes; receptor-mediated endocytosis; surface functionalization