Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New diagnostic criteria of fulminant type 1 diabetes mellitus (2012).
We have revised a part of the diagnostic criteria for fulminant type 1 diabetes. The new criteria were set both to express the essence of this disease of rapid increase of patients' blood glucose and to be highly sensitive to reduce the misdiagnosis. After analyzing the data of 382 patients with newly-diagnosed fulminant type 1 diabetes, we adopted the glycated hemoglobin (HbA1c) level of 8.7% (National Glycohemoglobin Standardization Program [NGSP] value). The new criterion indicates 100% of sensitivity and the best value by receiver operating characteristic curve analysis. In addition, we added a comment that 'This value (HbA1c <8.7% in NGSP) is not applicable for patients with previously diagnosed glucose intolerance' in the new criteria and also a comment that 'Association with human leukocyte antigen DRB1*04:05-DQB1*04:01 is reported' as a related finding. We did not revise the screening criteria and the other part of the diagnostic criteria, because they are still reliable.
Department of Metabolic Medicine Graduate School of Medicine, Osaka University Suita Japan.
Akihisa
A
Imagawa
Department of Internal Medicine (I) Osaka Medical College Takatsuki Japan.
Toshiaki
T
Hanafusa
Department of Endocrinology and Diabetes Saitama Medical University Japan.
Takuya
T
Awata
Department of Endocrinology, Metabolism and Diabetes Kinki University School of Medicine Osaka Japan.
Hiroshi
H
Ikegami
Diabetes Center Tokyo Women's Medical University School of Medicine Tokyo Japan.
Yasuko
Y
Uchigata
Department of Laboratory Medicine Ehime University School of Medicine Japan.
Haruhiko
H
Osawa
Department of Metabolism/Diabetes and Clinical Nutrition Nagasaki University Hospital Nagasaki Japan.
Eiji
E
Kawasaki
Department of Endocrinology, Metabolism and Diabetes Kinki University School of Medicine Osaka Japan.
Yumiko
Y
Kawabata
Third Department of Internal Medicine University of Yamanashi School of Medicine Yamanashi Japan.
Tetsuro
T
Kobayashi
Department of Internal Medicine Saiseikai Central Hospital Tokyo Japan.
Akira
A
Shimada
Department of Internal Medicine The Sakakibara Heart Institute of Okayama Okayama Japan.
Ikki
I
Shimizu
Department of Diabetes and Metabolism Iwate Medical University Morioka Japan.
Kazuma
K
Takahashi
Department of Internal Medicine Kakogawa Municipal Hospital Kakogawa Japan.
Masao
M
Nagata
Diabetes Center Shiraishi Hospital Japan Ehime Japan.
Hideichi
H
Makino
Department of Internal Medicine Saitama Social Insurance Hospital Saitama Japan.
Taro
T
Maruyama
Criteria; Diagnosis; Fulminant