G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.
An ever-increasing number of people world-wide are developing and suffering from heart failure, and existing therapies, although improved are not ideal. Therefore, innovative treatment strategies are urgently needed. As our understanding of the underlying dysfunction of the myocardium increases, so does our ability to target the mechanisms responsible for heart failure progression. In this review we discuss novel molecular therapies and approaches for the treatment of heart failure. We will focus on the G protein-coupled receptor kinase GRK2, an increasing target for heart failure therapy, based on its important role in disease progression and the therapeutic potential of GRK2 inhibitors.
Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, Medical Education Research Building, 3500 North Broad Street, MERB 940, Philadelphia, PA 19140, USA.
Sarah M
SM
Schumacher-Bass
Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, Medical Education Research Building, 3500 North Broad Street, MERB 940, Philadelphia, PA 19140, USA.
Christopher J
CJ
Traynham
Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, Medical Education Research Building, 3500 North Broad Street, MERB 940, Philadelphia, PA 19140, USA.
Walter J
WJ
Koch