Synthesis of 2-C-substituted benzothiazoles via a copper-promoted domino condensation/S-arylation/heterocyclization process.
Two series of extremely useful 2-C-substituted benzothiazoles containing gem-bisphosphonates and aryl-substituted nitriles were synthesized here via a copper-promoted domino condensation/S-arylation/heterocyclization process.
Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 20025, China. jiangm263@163.com.
Haoyue
H
Xiang
Jin
J
Qi
Qian
Q
He
Min
M
Jiang
Chunhao
C
Yang
Lianfu
L
Deng
D000814:Aniline Compounds / Q000737:chemistry; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D009570:Nitriles / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry
D000814:Aniline Compounds; D052160:Benzothiazoles; D009570:Nitriles; D010648:Phenylacetates; D003300:Copper; C025136:phenylacetic acid; C023650:aniline