Gastroesophageal reflux in chronic cough and cough syncope and the effect of antireflux treatment: case report and literature review.
OBJECTIVE
This study aimed to evaluate the efficacy of antireflux treatment on gastroesophageal reflux (GER)-related cough syncope.


METHODS
The method used was a retrospective review of the outcomes of antireflux treatment with proton pump inhibitor (PPI), Stretta radiofrequency (SRF), or laparoscopic fundoplication (LF) of 8 patients with chronic cough and cough syncope that was clinically evaluated to be GER related over a period of 2 to 5 years.


RESULTS
In the 8 selected cases, the typical GER symptoms disappeared in 7 cases and were significantly eased in 1 case. The chronic cough diminished to mild and occasional occurrence in 6 cases and was completely relieved in 2 cases. Meanwhile, the cough syncope disappeared in all cases. Seven of the patients resumed physical and social functions after the antireflux treatments, except for 1 person, who had a stroke due to other causes.


CONCLUSIONS
For chronic cough and cough syncope of unknown cause, the GER assessment could be valuable. In treating well-selected GER-related chronic cough and cough syncope, PPI, SRF, and LF can be considered. Moreover, satisfactory restoration of physical and social functions could be achieved after effective antireflux therapy.
Center for GER, the Second Artillery General Hospital, Beijing Normal University, Beijing, China Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhi-Wei
ZW
Hu
Center for GER, the Second Artillery General Hospital, Beijing Normal University, Beijing, China Xuanwu Hospital, Capital Medical University, Beijing, China zhonggaowang@126.com.
Zhong-Gao
ZG
Wang
Xuanwu Hospital, Capital Medical University, Beijing, China.
Yu
Y
Zhang
Xuanwu Hospital, Capital Medical University, Beijing, China.
Shu-Rui
SR
Tian
Xuanwu Hospital, Capital Medical University, Beijing, China.
Ji-Min
JM
Wu
Center for GER, the Second Artillery General Hospital, Beijing Normal University, Beijing, China.
Guang-Chang
GC
Zhu
Center for GER, the Second Artillery General Hospital, Beijing Normal University, Beijing, China.
Wei-Tao
WT
Liang
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003371:Cough / Q000209:etiology / Q000628:therapy*; D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D013575:Syncope / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
D054328:Proton Pump Inhibitors
antireflux; chronic cough; cough syncope; gastroesophageal reflux