Calcium, Orai1, and epidermal proliferation.
Ca(2+) influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca(2+) influx after Ca(2+) release from the endoplasmic reticulum, and it has now been shown to modulate epidermal atrophy. These findings reveal new interactions among various Ca(2+) signaling pathways and uncover novel functions for Ca(2+) signaling via the Orai1 channel.
Endocrine Research Unit, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California, USA.
Daniel D
DD
Bikle
Dermatology Research Unit, Department of Dermatology, VA Medical Center, University of California, San Francisco, San Francisco, California, USA. Electronic address: maurot@derm.ucsf.edu.
Theodora M
TM
Mauro
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D004817:Epidermis / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D000071740:ORAI1 Protein
D015220:Calcium Channels; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C520430:Orai1 protein, mouse