First trimester prediction of ischemic placental disease.
Ischemic placental disease is characterized by one or more of the clinical manifestations of preeclampsia, fetal growth restriction, and/or placental abruption, resulting in indicated preterm delivery. Since over half of the indicated preterm deliveries are due to ischemic placental disease, accurate early prediction of the disease is of paramount importance in developing prevention strategies. This review article focuses on studies that have used the first trimester aneuploidy screening timing window to predict those patients who later develop ischemic placental disease. Emphasis was given to studies originating from the Fetal Medicine Foundation because of their uniformity in definitions and expertise of the personnel who performed the ultrasound screening exams.
Department of Obstetrics and Gynecology, Winthrop-University Hospital, Mineola, NY 11501. Electronic address: avintzileos@winthrop.org.
Anthony M
AM
Vintzileos
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
Cande V
CV
Ananth
D000037:Abruptio Placentae / Q000175:diagnosis* / Q000517:prevention & control; D015415:Biomarkers; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000517:prevention & control; D005865:Gestational Age; D006801:Humans; D007511:Ischemia / Q000175:diagnosis*; D010920:Placenta / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D021041:Placental Circulation; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000517:prevention & control; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000517:prevention & control; D011261:Pregnancy Trimester, First; D047928:Premature Birth; D015203:Reproducibility of Results; D012307:Risk Factors; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal
D015415:Biomarkers
Fetal growth restriction; First trimester; Ischemic placental disease; Placental abruption; Prediction; Preeclampsia