68Ga DOTANOC PET/CT detects primary malignant insulinoma.
Malignant insulinoma is an extremely rare pancreatic tumor variant characterized by an aggressive clinical behavior with local and distant spread. Delays in the diagnosis are common because symptoms usually precede tumor detection and may be misattributed. Aggressive surgical resection is the primary treatment option; therefore accurate tumor localization is important for appropriate management. Although somatostatin receptor imaging has a limited role in the visualization of benign insulinoma (characterized by a low expression of somatostatin receptors), it can still have a role in the detection of malignant forms.
From the Departments of *Nuclear Medicine, and †Internal Medicine, Sant'Orsola-Malpighi University Hospital, Bologna; and ‡Department of Nuclear Medicine, Santa Maria della Misericordia, Rovigo, Italy.
Valentina
V
Ambrosini
Davide
D
Campana
Cristina
C
Nanni
Maria Cristina
MC
Marzola
Domenico
D
Rubello
Stefano
S
Fanti
D005260:Female; D006801:Humans; D007340:Insulinoma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D064847:Multimodal Imaging; D009942:Organometallic Compounds; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals