Which metabolic syndrome criteria best predict non-alcoholic fatty liver disease in children?
OBJECTIVE
The aim of this study was to identify which metabolic syndrome criteria (WHO or IDF) better reflect the presence of non-alcoholic fatty liver disease (NAFLD) and to determine the prevalence of metabolic syndrome (MS) and NAFLD.


METHODS
Two hundred and seventeen obese children and adolescents, 8-15 years of age (body mass index >95 p), were included in the study. Anthropometric measurements, blood pressure measurements, an oral glucose tolerance test and lipid profile were measured. MS was diagnosed according to WHO and IDF criteria. NAFLD risk ratio was assessed according to the two MS criteria.


RESULTS
The prevalence of MS according to the IDF criteria was 43.3 %, and according to WHO criteria it was 55.2 %. NAFLD prevalence in the metabolic syndrome group according to IDF criteria was 25.5 % and this was statistically significant (p = 0.007). The prevalence of NAFLD was 20.8 % in the group with MS according to WHO criteria and this was not a statistically significant difference (p = 0.15). NAFLD hazard ratios were 7.06 (95 % CI 1.29-5.50) in the MS group according to IDF criteria and 2.02 (95 % CI 0.81-3.53) in the group with metabolic syndrome according to WHO criteria. IDF criteria were found to have a higher odds ratio.


CONCLUSIONS
The prevalence of MS depends on the diagnostic criteria used. IDF criteria give the best measure for the presence of NAFLD. NAFLD might be important as diagnostic criterion for MS.
Necmettin Erbakan University, School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Konya, 42080, Turkey.
Mehmet Emre
ME
Atabek
Beray
B
Selver Eklioglu
Nesibe
N
Akyürek
D000293:Adolescent; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology*; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012307:Risk Factors; D014463:Ultrasonography