Gombaspiroketals A-C, sesterterpenes from the sponge Clathria gombawuiensis.
Gombaspiroketals A-C (1-3), tetracyclic sesterterpenes of a novel skeletal class, were isolated from the Korean marine sponge Clathria gombawuiensis. On the basis of the combined spectroscopic analyses, the structures of these compounds were determined to be highly rearranged sesterterpene spiroketal methoxyacetals (1 and 2) and a corresponding hemiacetal (3). The relative and absolute configurations were assigned by NOESY analysis and ECD calculations, respectively. These compounds exhibited moderate cytotoxicities and antibacterial activities.
Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
Jung-Kyun
JK
Woo
Chang-Kwon
CK
Kim
Seong-Hwan
SH
Kim
Heegyu
H
Kim
Dong-Chan
DC
Oh
Ki-Bong
KB
Oh
Jongheon
J
Shin
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry*; D008386:Marine Biology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D056910:Republic of Korea; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D054830:Sesterterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005663:Furans; D012717:Sesquiterpenes; D054830:Sesterterpenes; D013141:Spiro Compounds; C000591951:gombaspiroketal A; C000591952:gombaspiroketal B; C000591953:gombaspiroketal C; C520774:spiroketal