A Pd-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization: a new entry to 2-amino-phenols.
A palladium-catalyzed cascade reaction of N-H insertion (NHI) and oxidative dehydrogenative aromatization (ODA) has been developed, which affords a straightforward and efficient way to access the carbazole precursors (2-arylamino-phenols) as well as to prepare 2-alkylamino-phenols from non-aromatic substrates.
School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun08@gmail.com.
Dong
D
Ding
Xiaobing
X
Lv
Jian
J
Li
Lin
L
Qiu
Guangyang
G
Xu
Jiangtao
J
Sun
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D000627:Aminophenols / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006865:Hydrogenation; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D000470:Alkaloids; D000627:Aminophenols; D006841:Hydrocarbons, Aromatic; C027667:2-aminophenol; D010165:Palladium