Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease.
Numerous complications can be observed in the post-transplant period among recipients of hematopoietic stem cells including graft-versus-host disease (GVHD), which is associated with significant morbidity and mortality. On the other hand, graft versus tumor (GVT) effect is a well-described phenomenon in patients with hematologic malignancies and has also been reported in renal cell cancer, ovarian cancer, breast carcinoma, and melanoma. We describe spontaneous regression of a cutaneous invasive squamous cell carcinoma and multifocal atypical intraepidermal proliferations in a patient with chronic graft-versus-host disease following initiation of extracorporeal photopheresis (ECP). This observation raises questions regarding the GVT in cutaneous neoplasms and potential immunomodulatory effects of ECP.
Yevgeniy
Y
Balagula
Janis M
JM
Taube
Timothy
T
Wang
Amir H
AH
Dorafshar
Johns Hopkins School of Medicine.
Ronald J
RJ
Sweren
D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000276:immunology* / Q000473:pathology; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D056747:Immunomodulation; D008297:Male; D008875:Middle Aged; D017893:Photopheresis; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000150:complications / Q000276:immunology* / Q000473:pathology