Microscopic Enteritis; clinical features and correlations with symptoms.
OBJECTIVE
To assess the clinical characteristic of CD as well as correlation of symptoms and the degrees of intestinal mucosal lesions in Iranian children.


BACKGROUND
Microscopic Enteritis (Marsh 0-II) is associated with malabsorption.


METHODS
From August 2005 to September 2009, 111 cases with malabsorption and classical gastrointestinal symptoms were evaluated.


RESULTS
The mean (±SD) age of children with CD was 4.9±3.5 years (range, 6 month - 16 years) and the mean duration of symptoms was 8 ± 20.5 months. 50 cases (45%) were female and 61 cases (55%) were male. The most common clinical presentation was failure to thrive in 72%, chronic diarrhea in 65.8% and Iron deficiency anemia in 59.5%. Sensitivity of EMA was 100% in patients with Marsh IIIb and Marsh IIIc. EMA was also positive in 77% of cases with Marsh 0, 18% in Marsh I, 44% in Marsh II and 81.8% in patients with Marsh IIIa.


CONCLUSIONS
Histopathology did not reflect the severity of gluten sensitivity. This would suggest that the degree of intestinal mucosal damage might not be a reliable prognostic factor. Significant symptoms can be present with minor histological change on biopsy.
Department of Pediatrics, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Touran
T
Shahraki
School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom.
Kamran
K
Rostami
Department of Nutrition, and Research Center for Children and Adolescent Health, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mansour
M
Shahraki
Institute of Health, Social Care and Psychology University of Worcester UK.
Justine
J
Bold
Department of Pathology, University of Medicine and Pharmacy Iasi, Romania.
Mihai
M
Danciu
Department of Gastroenterology, Alexander Hospital, Redditch, UK.
David
D
Al Dulaimi
2nd Department of Pathology, Spedali Civili University of Brescia Italy.
Vincenzo
V
Villanacci
Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy.
Gabrio
G
Bassotti
Coeliac disease; Histology; Macroscopic enteritis; Serology