A new sesquiterpene from the Hainan gorgonian Menella kanisa Grassoff.
Chemical investigation of the gorgonian Menella kanisa Grassoff collected from the South China Sea led to the isolation of a new sesquiterpene, menecubebane A (1), together with three known compounds, 8-methoxy-trans-calamenene (2), 8,9-dihydro-linderazulene (3) and (3β)-oleanan-3-ol (4). The structure of 1 was determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. All the compounds were evaluated for their cytotoxic, brine shrimp lethal and antifouling activities.
a Key Laboratory of Marine Drugs , The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , 5 Yushan Road, Qingdao 266003 , Shandong , P.R. China.
Min
M
Chen
Lei
L
Han
Yu
Y
Wang
Xiu-Li
XL
Zhang
Chang-Yun
CY
Wang
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D057219:Biofouling / Q000517:prevention & control; D002681:China; D004354:Drug Screening Assays, Antitumor; D005260:Female; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D008297:Male; D009792:Oceans and Seas; D011471:Prostatic Neoplasms; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D012717:Sesquiterpenes; C000592991:menecubebane A
Menella kanisa Grassoff; gorgonian; sesquiterpene; structure elucidation