Helicases, G4-DNAs, and drug design.
New helicase assays that recognise therapeutically important G4-DNA structures will lead to the discovery of novel molecular entities that bind not only to G4-tetrads, but also to grooves and loops of G4-DNA. Such assays can also provide inhibitors of G4-specific helicases that will shed light on the emerging involvement of helicases in cancer and other diseases linked to defective DNA repair pathways.
Institute of Fundamental Sciences, Massey University, Private Bag 11 222, Palmerston North (New Zealand), Fax: (+64) 6 350 5682.
Tracy K
TK
Hale
Gillian E
GE
Norris
Geoffrey B
GB
Jameson
Vyacheslav V
VV
Filichev
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D004265:DNA Helicases / Q000037:antagonists & inhibitors / Q000737:chemistry*; D004260:DNA Repair / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D054856:G-Quadruplexes; D057166:High-Throughput Screening Assays; D006801:Humans; D019098:Telomerase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D019098:Telomerase; D004265:DNA Helicases
G-quadruplexes; cancer; helicase; screening; telomerase