Human iPSC-derived miniature organs: a tool for drug studies.
In vitro organogenesis is now becoming a realistic goal of stem cell biology, as one can obtain an unlimited number of pluripotent stem cells through reprogramming technology. One practical challenge is to develop a four-dimensional (4-D) stem cell culture system whereby multiple progenitors communicate in a spatiotemporal manner, as observed during in vivo organogenesis. This perspective summarizes the potential for emerging culture platforms in the future application of induced pluripotent stem cell (iPSC)-derived miniature organs by recapitulating early embryogenesis.
1] Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan [2] PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan.
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Takebe
Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
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Taniguchi
D018929:Cell Culture Techniques; D002478:Cells, Cultured; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000187:drug effects* / Q000378:metabolism*; D038081:Organogenesis; D023822:Tissue Engineering; D018675:Toxicity Tests / Q000379:methods*