The emerging role of biotechnological drugs in the treatment of gout.
One of the most important therapeutic advances obtained in the field of rheumatology is the availability of the so-called bio(techno)logical drugs, which have deeply changed treatment perspectives in diseases such as rheumatoid arthritis and ankylosing spondylitis. According to the steadily increasing attention on gout, due to well-established prognostic and epidemiology implications, in the last 5 years, the same change of perspective has been observed also for this disease. In fact, several bio(techno)logical agents have been investigated both for the management of the articular gout symptoms, targeting mainly interleukin-1 β , as well as urate-lowering therapies such as recombinant uricases. Among the IL-1 β inhibitors, the majority of studies involve drugs such as anakinra, canakinumab, and rilonacept, but other compounds are under development. Moreover, other potential targets have been suggested, as, for example, the TNF alpha and IL-6, even if data obtained are less robust than those of IL-1 β inhibitors. Regarding urate-lowering therapies, the recombinant uricases pegloticase and rasburicase clearly showed their effectiveness in gout patients. Also in this case, new compounds are under development. The aim of this review is to focus on the various aspects of different bio(techno)logical drugs in gouty patients.
Division of Rheumatology, University and IRCCS Policlinico S.Matteo Foundation, Viale Golgi 2, 27100 Pavia, Italy.
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Cavagna
Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago Wellington 6242, New Zealand.
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WJ
Taylor
D001709:Biotechnology / Q000379:methods*; D016207:Cytokines / Q000378:metabolism; D006073:Gout / Q000188:drug therapy* / Q000378:metabolism; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014503:Urate Oxidase / Q000627:therapeutic use*; D014527:Uric Acid / Q000378:metabolism
D016207:Cytokines; D006074:Gout Suppressants; D011994:Recombinant Proteins; D014527:Uric Acid; D011092:Polyethylene Glycols; D014503:Urate Oxidase; C031545:Pegloticase