Evolution of the binge drinking pattern in college students: neurophysiological correlates.
It is well known that alcohol impairs response inhibition and that adolescence is a critical period of neuromaturation where cognitive processes such as inhibitory control are still developing. In recent years, growing evidence has shown the negative consequences of alcohol binge drinking on the adolescent and young human brain. However, the effects of cessation of binge drinking on brain function remain unexplored. The objective of the present study was to examine brain activity during response execution and inhibition in young binge drinkers in relation to the progression of their drinking habits over time. Event-related potentials (ERPs) elicited by a Go/NoGo task were recorded twice within a 2-year interval in 57 undergraduate students (25 controls, 22 binge drinkers, and 10 ex-binge drinkers) with no personal or family history of alcoholism or psychopathological disorders. The results showed that the amplitude of NoGo-P3 over the frontal region correlated with an earlier age of onset of regular drinking as well as with greater quantity and speed of alcohol consumption. Regression analysis showed that NoGo-P3 amplitude was significantly predicted by the speed of alcohol intake and the age of onset of regular drinking. The group comparisons showed that, after maintaining a binge drinking pattern for at least 2 years, binge drinkers displayed significantly larger NoGo-P3 amplitudes than controls, whereas ex-binge drinkers were in an intermediate position between the two other groups (with no significant differences with respect to controls or binge drinkers). These findings suggest that binge drinking in young people may impair the neural functioning related to inhibitory processes, and that the cessation of binge drinking may act as a brake on the neurophysiological impairments related to response inhibition.
Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782 Galicia, Spain. Electronic address: eduardo.lopez@usc.es.
Eduardo
E
López-Caneda
Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782 Galicia, Spain.
Socorro
S
Rodríguez Holguín
Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782 Galicia, Spain.
Montserrat
M
Corral
Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782 Galicia, Spain.
Sonia
S
Doallo
Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782 Galicia, Spain.
Fernando
F
Cadaveira
D000293:Adolescent; D017668:Age of Onset; D000428:Alcohol Drinking / Q000523:psychology; D063425:Binge Drinking / Q000503:physiopathology*; D000431:Ethanol / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D009482:Neurophysiology; D011930:Reaction Time / Q000187:drug effects; D013334:Students; D055815:Young Adult
D000431:Ethanol
Adolescence; Alcohol; Binge drinking; Event-related potentials; Inhibitory control; Response inhibition