Reduction in developmental coordination disorder with neonatal caffeine therapy.
OBJECTIVE
To determine the effect of neonatal caffeine treatment on rates of developmental coordination disorder (DCD).


METHODS
Children in the Caffeine for Apnea of Prematurity trial were assessed for motor performance (Movement Assessment Battery for Children [MABC]), clinical signs of cerebral palsy, and Full-Scale IQ at 5 years of age by staff who were unaware of the children's treatment group. DCD was defined as MABC<5th percentile in children with a Full-Scale IQ>69 who did not have a diagnosis of cerebral palsy.


RESULTS
There were 1433 children with known MABC corrected-age percentile as well as known Full-Scale IQ at 5 years and cerebral palsy status, of whom 735 had been randomly assigned to caffeine and 698 to placebo therapy. The rate of DCD was lower in those treated with caffeine (11.3%) than in the placebo group (15.2%) (OR adjusted for center and baseline covariates, 0.71, 95% CI, 0.52-0.97; P=.032).


CONCLUSIONS
Neonatal caffeine therapy for apnea of prematurity reduces the rate of DCD at 5 years of age. As more children have DCD than have cerebral palsy, this is an important additional benefit from neonatal caffeine treatment.
Department of Obstetrics and Gynecology, University of Melbourne and The Royal Women's Hospital, Melbourne, Victoria, Australia; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Lex W
LW
Doyle
Division of Neonatology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Barbara
B
Schmidt
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Peter J
PJ
Anderson
Department of Obstetrics and Gynecology, University of Melbourne and The Royal Women's Hospital, Melbourne, Victoria, Australia; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
Peter G
PG
Davis
University of Manitoba, Winnipeg, Canada.
Diane
D
Moddemann
University of British Columbia, Vancouver, Canada.
Ruth E
RE
Grunau
Mount Sinai Hospital, Toronto, Ontario, Canada.
Karel
K
O'Brien
University of Saskatchewan, Saskatoon, Canada.
Koravangattu
K
Sankaran
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Eric
E
Herlenius
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Robin
R
Roberts
D001049:Apnea / Q000150:complications / Q000188:drug therapy*; D002110:Caffeine / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D019957:Motor Skills Disorders / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome
D002110:Caffeine