Surgical treatment of an isolated omental cervical cancer recurrence: report of a case and review of the literature.
OBJECTIVE
Recurrent cervical cancer has traditionally been associated with a dismal prognosis. Historically, patients who developed distant metastases from cervical cancer were not considered eligible for surgical resection; only palliative treatment options are available, generally consisting of chemo- and/or radiotherapy. Metastases usually appear in the liver, lung or lymph nodes. The abdominal cavity is a quite unusual site of recurrence and the disease usually has multiple foci. For this reason, peritoneal involvement by cervical cancer is considered a contraindication to local treatment.


METHODS
We report the first case of a 30-year-old woman with isolated intra-abdominal cervical cancer recurrence diagnosed with 18F-FDG PET/CT, successfully surgically treated.


RESULTS
Histopathological analysis confirmed the tumor to be an omental relapse of squamous cervical cancer previously treated with anterior pelvic exenteration and platinum based chemotherapy. The patient underwent adjuvant treatment with 3 cycles of topotecan and has remained free of disease during the 4 years of follow-up.


CONCLUSIONS
In selected cases with isolated recurrences, a surgical resection may provide a long term complete remission in recurrent cervical cancer patients.
Maria Luisa
ML
Gasparri
Filippo
F
Bellati
Milena
M
Pernice
Violante
V
Di Donato
Giuseppina
G
Morano
Claudia
C
Marchetti
Cristina
C
Donfrancesco
Morena
M
Antonilli
Pierluigi
P
Benedetti Panici
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000601:surgery*; D009852:Omentum / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed; D059004:Topoisomerase I Inhibitors / Q000627:therapeutic use; D019772:Topotecan / Q000627:therapeutic use; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D003287:Contrast Media; D059004:Topoisomerase I Inhibitors; D019788:Fluorodeoxyglucose F18; D019772:Topotecan