Reconstructing the evolutionary origins and phylogeography of hantaviruses.
Rodents have long been recognized as the principal reservoirs of hantaviruses. However, with the discovery of genetically distinct and phylogenetically divergent lineages of hantaviruses in multiple species of shrews, moles, and insectivorous bats from widely separated geographic regions, a far more complex landscape of hantavirus host distribution, evolution, and phylogeography is emerging. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne hantaviruses and newly detected non-rodent-borne hantaviruses, indicate an Asian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial hantaviruses.
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA; Department of Microbiology, California Academy of Sciences, San Francisco, CA, USA.
Shannon N
SN
Bennett
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA.
Se Hun
SH
Gu
Division of Respiratory Viruses, Korea National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Korea.
Hae Ji
HJ
Kang
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
Satoru
S
Arai
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA; Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA. Electronic address: ryanagih@hawaii.edu.
Richard
R
Yanagihara
D000818:Animals; D000835:Animals, Wild; D004197:Disease Reservoirs; D019143:Evolution, Molecular; D006476:Orthohantavirus / Q000235:genetics*; D058974:Phylogeography
Chiroptera; Eulipotyphla; evolution; hantavirus; host-switching