Modulating materials by orthogonally oriented β-strands: composites of amyloid and silk fibroin fibrils.
Amyloid fibrils and silk fibroin (SF) fibrils are proteinaceous aggregates occurring either naturally or as artificially reconstituted fibrous systems, in which the constituent β-strands are aligned either orthogonally or parallel to the fibril main axis, conferring complementary physical properties. Here, it is shown how the combination of these two classes of protein fibrils with orthogonally oriented β-strands results in composite materials with controllable physical properties at the molecular, mesoscopic, and continuum length scales.
Food & Soft Materials Science, Institute of Food, Nutrition & Health, ETH Zürich, LFO23 Schmelzbergstrasse 9, 8092, Zürich, Switzerland; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, PR China.
Shengjie
S
Ling
Chaoxu
C
Li
Jozef
J
Adamcik
Zhengzhong
Z
Shao
Xin
X
Chen
Raffaele
R
Mezzenga
D000682:Amyloid / Q000737:chemistry* / Q000648:ultrastructure; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D005349:Fibroins / Q000737:chemistry* / Q000648:ultrastructure; D007782:Lactoglobulins / Q000737:chemistry / Q000648:ultrastructure; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D013718:Tensile Strength; D014961:X-Ray Diffraction
D000682:Amyloid; D001672:Biocompatible Materials; D007782:Lactoglobulins; D005349:Fibroins
amyloid fibrils; molecular orientation; nanocomposites; silk fibroin; β-strands; β-sheets