Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates.
Highly efficient Pd-catalyzed asymmetric allylic alkylation reaction of ethyl-2-fluoro-2-(diethoxyphosphoryl)acetate with monosubstituted allylic substrates has been developed, affording corresponding α-fluorophosphonates with two chiral centers in high regio-, diastereo- and enantio-selectivities. The usefulness of the products in organic synthesis has been demonstrated.
State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Ying
Y
Huang
Qing-Song
QS
Zhang
Ping
P
Fang
Tie-Gen
TG
Chen
Jun
J
Zhu
Xue-Long
XL
Hou
D000478:Alkylation; D000498:Allyl Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D007202:Indicators and Reagents; D008024:Ligands; D063066:Organofluorophosphonates / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000498:Allyl Compounds; D007202:Indicators and Reagents; D008024:Ligands; D063066:Organofluorophosphonates; D010165:Palladium