Two cases of neonatal human parechovirus 3 encephalitis.
We report 2 neonates with human parechoviruses type 3 encephalitis. Both newborns presented with fever, irritability and seizures. Cerebrospinal fluid analyses were normal, but magnetic resonance imaging revealed white matter damage, suggesting human parechoviruse infection. Human parechoviruses type 3-RNA was detected in cerebrospinal fluid samples and in blood, stool, urine and respiratory samples, indicating the dissemination of the virus.
From the *Department of Biomedical Sciences for Health; †Neonatal Intensive Care Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan; and ‡Neonatal Intensive Care Unit, General Hospital "Azienda Ospedaliera Sant'Anna", Como, Italy.
Elena
E
Pariani
Laura
L
Pellegrinelli
Lorenza
L
Pugni
Paolo
P
Bini
Simona
S
Perniciaro
Laura
L
Bubba
Valeria
V
Primache
Antonella
A
Amendola
Mario
M
Barbarini
Fabio
F
Mosca
Sandro
S
Binda
D001284:Atrophy / Q000821:virology; D001921:Brain / Q000473:pathology*; D004569:Electroencephalography; D018792:Encephalitis, Viral / Q000821:virology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D030061:Parechovirus; D010850:Picornaviridae Infections / Q000175:diagnosis; D012640:Seizures / Q000821:virology