Effects of lipids and lipoproteins on diabetic foot in people with type 2 diabetes mellitus: a meta-analysis.
BACKGROUND
To conduct a meta-analysis of case-control studies to determine the effects of lipids and lipoproteins on morbidity of diabetic foot in adults with type 2 diabetes.


METHODS
We searched the PubMed and EMBASE to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to determine the quality of selected studies. We assessed the strength of associations using standardized mean differences with 95% confidence intervals.


RESULTS
A total of 4 articles were found. Decreased HDL-cholesterol had a significant association with diabetic foot susceptibility in fixed-effects model, but no significant associations were found between diabetic foot and LDL-cholesterol, TC or TG levels.


CONCLUSIONS
Our results suggested that decreased HDL-cholesterol was associated with diabetic foot, so possible measures to prevent diabetic foot should include targeting increases in HDL-cholesterol.
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China; Institute of Medical Intervention Engineering, Tongji University, North Zhongshan Road, Shanghai, China.
Erli
E
Pei
Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Siping Road, Shanghai, China.
Jue
J
Li
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China.
Chenhui
C
Lu
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China.
Jichong
J
Xu
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China.
Tao
T
Tang
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China.
Meng
M
Ye
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China; Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Siping Road, Shanghai, China. Electronic address: zxpkxy@126.com.
Xiaoping
X
Zhang
Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China; Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Siping Road, Shanghai, China. Electronic address: cjr.limaoquan@163.vip.com.
Maoquan
M
Li
D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D017719:Diabetic Foot / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D003927:Diet, Diabetic; D018752:Diet, Fat-Restricted; D059305:Diet, High-Fat / Q000009:adverse effects; D004198:Disease Susceptibility; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D012307:Risk Factors; D015854:Up-Regulation
D008076:Cholesterol, HDL
Diabetic foot; Lipids; Lipoproteins; Meta-analysis; Risk factors