Single sodium pyruvate ingestion modifies blood acid-base status and post-exercise lactate concentration in humans.
This study examined the effect of a single sodium pyruvate ingestion on a blood acid-base status and exercise metabolism markers. Nine active, but non-specifically trained, male subjects participated in the double-blind, placebo-controlled, crossover study. One hour prior to the exercise, subjects ingested either 0.1 g·kg(-1) of body mass of a sodium pyruvate or placebo. The capillary blood samples were obtained at rest, 60 min after ingestion, and then three and 15 min after completing the workout protocol to analyze acid-base status and lactate, pyruvate, alanine, glucose concentrations. The pulmonary gas exchange, minute ventilation and the heart rate were measured during the exercise at a constant power output, corresponding to ~90% VO2max. The blood pH, bicarbonate and the base excess were significantly higher after sodium pyruvate ingestion than in the placebo trial. The blood lactate concentration was not different after the ingestion, but the post-exercise was significantly higher in the pyruvate trial (12.9 ± 0.9 mM) than in the placebo trial (10.6 ± 0.3 mM, p < 0.05) and remained elevated (nonsignificant) after 15 min of recovery. The blood pyruvate, alanine and glucose concentrations, as well as the overall pulmonary gas exchange during the exercise were not affected by the pyruvate ingestion. In conclusion, the sodium pyruvate ingestion one hour before workout modified the blood acid-base status and the lactate production during the exercise.
Biochemistry Department, Gdansk University of Physical Education and Sport, Gorskiego 1, 80-336 Gdansk, Poland. robol@awf.gda.pl.
Robert A
RA
Olek
Physiology Department, Gdansk University of Physical Education and Sport, Gorskiego 1, 80-336 Gdansk, Poland. sylwek-kujach@o2.pl.
Sylwester
S
Kujach
Department of Physiotherapy, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland. damianwnuk@gumed.edu.pl.
Damian
D
Wnuk
Physiology Department, Gdansk University of Physical Education and Sport, Gorskiego 1, 80-336 Gdansk, Poland. lasradek@awf.gda.pl.
Radoslaw
R
Laskowski
D000136:Acid-Base Equilibrium; D000328:Adult; D000409:Alanine / Q000097:blood; D001639:Bicarbonates / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D019289:Pyruvic Acid / Q000008:administration & dosage* / Q000097:blood; D064133:Sports Nutritional Physiological Phenomena; D055815:Young Adult
D001639:Bicarbonates; D015415:Biomarkers; D001786:Blood Glucose; D007773:Lactates; D019289:Pyruvic Acid; D000409:Alanine