Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism.
Spinal metastasis, a devastating neurologic complication of intracranial glioblastomas is not as uncommon as initially thought. It varies from 25% in supratentorial glioblastomas to 60% in infratentorial glioblastomas. The underlying pathogenesis spinal spread of high-grade gliomas is still unclear. To date, no causal responsibility of Bevacizumab (BEV) was noted. Here, we report for the first time, a case of thoracic intramedullary metastases from a cerebral glioblastoma pre-treated with BEV. A critical and exhaustive review is provided.
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Gentian
G
Kaloshi
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Arben
A
Roji
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Arsen
A
Seferi
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Bujar
B
Cakani
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Teona
T
Bushati
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Ermir
E
Roci
Department of neurosurgery, University Hospital Center "Mother Theresa", Tirana, Albania.
Mentor
M
Petrela
Glioblastoma; bevacizumab; lepto-meningeal seeding