Tumor/stromal caveolin-1 expression patterns in pleural mesothelioma define a subgroup of the epithelial histotype with poorer prognosis.
OBJECTIVE
Malignant pleural mesothelioma (MPM) is a highly aggressive disease for which new prognostic biomarkers need to be identified. Caveolin-1 (CAV1), the most important member of caveolae, has been described as deregulated in MPM at the genomic level, but detailed histologic information on its distribution and prognostic role is still lacking.


METHODS
A series of 131 MPMs (91 epithelial, 17 biphasic, and 23 sarcomatous histotype) were investigated for CAV1 expression with immunohistochemistry and correlated with clinical-pathologic variables and outcome.


RESULTS
CAV1 was detected in neoplastic cells of 70 (77%) of 91 epithelial, 17 (100%) of 17 biphasic, and 23 (100%) of 23 sarcomatous MPMs. Furthermore, in the epithelial group, CAV1 expression in spindle-shaped stromal cells was detected in 61 (67%) of 91 cases.


CONCLUSIONS
The presence of stromal CAV1 expression was associated with a worse patient outcome. In MPM, CAV1 is differentially expressed according to low- to high-grade histotypes. Furthermore, in the MPM epithelial group, additional stromal CAV1 expression is associated with a worse prognosis.
From the Departments of Oncology and luisella.righi@unito.it.
Luisella
L
Righi
From the Departments of Oncology and.
Maria Cristina
MC
Cavallo
From the Departments of Oncology and.
Gaia
G
Gatti
From the Departments of Oncology and.
Valentina
V
Monica
From the Departments of Oncology and.
Ida
I
Rapa
From the Departments of Oncology and.
Simone
S
Busso
Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.
Carlo
C
Albera
From the Departments of Oncology and.
Marco
M
Volante
From the Departments of Oncology and.
Giorgio V
GV
Scagliotti
From the Departments of Oncology and.
Mauro
M
Papotti
D000368:Aged; D051242:Caveolin 1 / Q000378:metabolism*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
C495540:CAV1 protein, human; D051242:Caveolin 1
Biomarker; Caveolin-1; Mesothelioma; Prognosis; Stroma