Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series.
OBJECTIVE
Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease.


METHODS
Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects.


CONCLUSIONS
This case series indicates that CBD is able to control the symptoms of RBD.
Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; INCT Translational Medicine (CNPq), São Paulo, Brazil.
M H N
MH
Chagas
A L
AL
Eckeli
A W
AW
Zuardi
M A
MA
Pena-Pereira
M A
MA
Sobreira-Neto
E T
ET
Sobreira
M R
MR
Camilo
M M
MM
Bergamaschi
C H
CH
Schenck
J E C
JE
Hallak
V
V
Tumas
J A S
JA
Crippa
D000368:Aged; D002185:Cannabidiol / Q000627:therapeutic use*; D002188:Cannabis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease; D008517:Phytotherapy; D020187:REM Sleep Behavior Disorder / Q000188:drug therapy*
D002185:Cannabidiol
Parkinson's disease; cannabidiol; rapid eye movement sleep behaviour disorder