Effect of essential oil of Rosa Damascena on human colon cancer cell line SW742.
OBJECTIVE
In this study, we report the effect of the essential oil of Rosa Damascena on human colon cancer cell line (SW742) and human fibroblast cells.


BACKGROUND
Colon cancer is the second most common fatal malignancy. Owing to the existence of many side effects and problems related to common treatments such as surgery, chemotherapy and radiotherapy, alternative treatments are being investigated. Some herbal medicines have shown promising results against different types of cancers. Herbal medicines used have included the use naturally occurring essential oils.


METHODS
The essential oil of Rosa Damascena was obtained by distillation and its effect on SW742 cell-line and fibroblast cells were investigated with cell culture. The cells were cultured and different volumes of essential oil were induced to the cells. After48hincubation, cell survival was measured and using statistical analysis, the findings were evaluated and reported.


RESULTS
This study showed that soluble part of Rosa Damascena oil increases cell proliferation in high volumes and the non-soluble component decreases cell proliferation.


CONCLUSIONS
The effects of essential oils, such as Rosa Damascena, on cell proliferation require more thorough investigation.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mostafa
M
Rezaie-Tavirani
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Setareh
S
Fayazfar
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeid
S
Heydari-Keshel
Institute of Forest and Rangelands, Tehran, Iran.
Mohamad Bagher
MB
Rezaee
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mona
M
Zamanian-Azodi
Departmet of Surgery, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Majid
M
Rezaei-Tavirani
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Reza
R
Khodarahmi
Cell survival; Colon cancer cell line (SW742); Essential oil; Human fibroblast cell; Rosa Damascena