[Outcomes of percutaneous coronary intervention for intermediate coronary artery disease guided by intravascular ultrasound or fractional flow reserve].
OBJECTIVE
To evaluate the long-term clinical outcomes of fractional flow reserve (FFR)-guided versus intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for intermediate coronary lesions.


METHODS
A total of 226 patients with 293 intermediate coronary artery lesions (stenosis of 40%-70%) confirmed by coronary angiography were randomized into 3 groups to undergo PCI for a minimal lumen cross sectional area (MLA)<4 mm(2) (IVUS group, 98 lesions) or for a FFR<0.80 (FFR group, 101 lesions), or to receive standard medical treatment (medication group, 94 lesions). The primary outcome was major adverse cardiac events including death, myocardial infarction, and ischemia-driven target vessel revascularization at 1 year after the index procedure.


RESULTS
The baseline percent diameter stenosis and lesion length were similar between the 3 groups, but more patients in IVUS group than in FFR group received PCI (P<0.001). No significant difference was found in the incidence of major adverse cardiac events between the 3 groups (P=0.182).


CONCLUSIONS
Both FFR- and IVUS-guided PCI strategy for intermediate coronary artery disease are associated with favorable outcomes, but IVUS-guided PCI based on the single index of MLA can increase the rate of revascularization therapy.
Department of Cardiology, Shenzhen Sun Yatsen Cardiovascular Hospital, Shenzhen 518020, China. E-mail: violet_2003163@163.com?
Huihua
H
Zuo
Qiang
Q
Liu
Zhiling
Z
Zhang
Lili
L
Wang
Jianxin
J
Weng
Yi
Y
Wei
Xinlin
X
Luo
Qiying
Q
Chen
Qian
Q
Cao
D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000601:surgery*; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D009203:Myocardial Infarction; D062645:Percutaneous Coronary Intervention