Deep brain stimulation for movement disorders.
Deep brain stimulation (DBS) is an implanted electrical device that modulates specific targets in the brain resulting in symptomatic improvement in a particular neurologic disease, most commonly a movement disorder. It is preferred over previously used lesioning procedures due to its reversibility, adjustability, and ability to be used bilaterally with a good safety profile. Risks of DBS include intracranial bleeding, infection, malposition, and hardware issues, such migration, disconnection, or malfunction, but the risk of each of these complications is low--generally ≤ 5% at experienced, large-volume centers. It has been used widely in essential tremor, Parkinson's disease, and dystonia when medical treatment becomes ineffective, intolerable owing to side effects, or causes motor complications. Brain targets implanted include the thalamus (most commonly for essential tremor), subthalamic nucleus (most commonly for Parkinson's disease), and globus pallidus (Parkinson's disease and dystonia), although new targets are currently being explored. Future developments include brain electrodes that can steer current directionally and systems capable of "closed loop" stimulation, with systems that can record and interpret regional brain activity and modify stimulation parameters in a clinically meaningful way. New, image-guided implantation techniques may have advantages over traditional DBS surgery.
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, San Francisco, CA, 94143-0112, USA, larsonp@neurosurg.ucsf.edu.
Paul S
PS
Larson
D001921:Brain / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods*; D004421:Dystonia / Q000628:therapy; D020329:Essential Tremor / Q000628:therapy; D005917:Globus Pallidus / Q000503:physiopathology; D006801:Humans; D009069:Movement Disorders / Q000628:therapy*; D010300:Parkinson Disease / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology