Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies.
BACKGROUND
A single dose or short course of primaquine given to people infected with malaria may reduce transmission of Plasmodium falciparum through its effects on gametocytes. Primaquine is also known to cause haemolysis in people with variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency. The objective of this systematic review was to assess the risk of adverse effects in people with G6PD deficiency given primaquine or other 8-aminoquinoline (8AQ) as a single dose or short course (less than 7 days).


METHODS
We will search the following databases: Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS. Prospective cohort studies, randomised and quasi-randomised trials that evaluated 8AQs for whatever reason in adults or children with a known G6PD deficiency will be included. Two authors will independently assess each study for eligibility, risk of bias and extract data.


BACKGROUND
This systematic review will be published in a peer-reviewed journal. Brief reports of the review findings will be disseminated directly to the appropriate audiences and the WHO Technical Expert Group in Malaria Chemotherapy. As no primary data collection will be undertaken, no additional formal ethical assessment and informed consent are required.
The protocol is registered with PROSPERO, registration number CRD42013006518.
Division of Health Sciences, Warwick-Centre for Applied Health Research and Delivery (WCAHRD), Warwick Medical School, University of Warwick, Coventry, UK Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine, Liverpool, UK.
Olalekan A
OA
Uthman
Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine, Liverpool, UK.
Rachel
R
Saunders
Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine, Liverpool, UK.
David
D
Sinclair
School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Cairns, Australia.
Patricia
P
Graves
Center for Disease Dynamics, Economics & Policy, Washington, District of Columbia, USA.
Hellen
H
Gelband
Division of Health Sciences, Warwick-Centre for Applied Health Research and Delivery (WCAHRD), Warwick Medical School, University of Warwick, Coventry, UK.
Aileen
A
Clarke
Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine, Liverpool, UK.
Paul
P
Garner
D000634:Aminoquinolines / Q000009:adverse effects*; D000962:Antimalarials / Q000009:adverse effects*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000188:drug therapy*; D011319:Primaquine / Q000009:adverse effects*; D011446:Prospective Studies; D012107:Research Design; D000078202:Systematic Reviews as Topic
D000634:Aminoquinolines; D000962:Antimalarials; D011319:Primaquine; C080436:8-aminoquinoline
Infectious Diseases; Preventive Medicine; Public Health