The contribution of neuronal-glial-endothelial-epithelial interactions to colon carcinogenesis.
Several different cell types constitute the intestinal wall and interact in different manners to maintain tissue homeostasis. Elegant reports have explored these physiological cellular interactions revealing that glial cells and neurons not only modulate peristalsis and mechanical stimulus in the intestines but also control epithelial proliferation and sub-epithelial angiogenesis. Although colon carcinoma arises from epithelial cells, different sub-epithelial cell phenotypes are known to support the manifestation and development of tumors from their early steps on. Therefore, new perspectives in cancer research have been proposed, in which neurons and glial cells not only lead to higher cancer cell proliferation at the tumor invasion front but also further enhance angiogenesis and neurogenesis in tumors. Transformation of physiological neural activity into a pro-cancer event is thus discussed for colon carcinogenesis herein.
Department of Pathology, Medical School of Ribeirão Preto, University of Sao Paulo, Av. Bandeirantes 3900, 14, Ribeirão Preto, 049-900, Brazil.
Sergio Britto
SB
Garcia
Helga
H
Stopper
Vinicius
V
Kannen
D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology*; D000236:Adenoma / Q000209:etiology / Q000473:pathology; D000818:Animals; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology / Q000473:pathology*; D018450:Disease Progression; D042783:Endothelial Cells / Q000502:physiology*; D017615:Enteric Nervous System / Q000473:pathology; D004847:Epithelial Cells / Q000502:physiology*; D025461:Feedback, Physiological; D006801:Humans; D007249:Inflammation; D007413:Intestinal Mucosa / Q000473:pathology; D007422:Intestines / Q000098:blood supply; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D009361:Neoplasm Invasiveness; D014411:Neoplastic Stem Cells / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D059016:Tumor Microenvironment
D012701:Serotonin