Nickel-catalyzed redox-economical coupling of alcohols and alkynes to form allylic alcohols.
We have developed a redox-economical coupling reaction of alcohols and alkynes to form allylic alcohols under mild conditions. The reaction is redox-neutral as well as redox-economical and thus free from any additives such as a reductant or an oxidant. This atom-economical coupling can be applied for the conversion of both aliphatic and benzylic alcohols to the corresponding substituted allylic alcohols in a single synthetic operation.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University , Kyoto 615-8510, Japan.
Kenichiro
K
Nakai
Yuji
Y
Yoshida
Takuya
T
Kurahashi
Seijiro
S
Matsubara