Perfluorooctanoic acid rigidifies a model lipid membrane.
We report a combined dynamic light scattering and neutron spin-echo (NSE) study on vesicles composed of the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine under the influence of varying amounts of perfluorooctanoic acid. We study local lipid bilayer undulations using NSE on time scales up to 200 ns. Similar to the effect evoked by cholesterol, we attribute the observed lipid bilayer stiffening to a condensing effect of the perfluorinated compound on the membrane.
Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin, Berlin, Germany and Reactor Institute Delft, Delft University of Technology, Delft, The Netherlands.
B
B
Brüning
Time-of-Flight and High Resolution, Institut Laue-Langevin, Grenoble, France.
B
B
Farago
D002210:Caprylates / Q000737:chemistry*; D003198:Computer Simulation; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D055119:Elastic Modulus; D005466:Fluorocarbons / Q000737:chemistry*; D006244:Hardness; D008051:Lipid Bilayers / Q000737:chemistry*; D008422:Materials Testing; D008560:Membrane Fluidity; D008956:Models, Chemical; D008958:Models, Molecular; D012997:Solvents / Q000737:chemistry; D013314:Stress, Mechanical
D002210:Caprylates; D005466:Fluorocarbons; D008051:Lipid Bilayers; D012997:Solvents; C023036:perfluorooctanoic acid; D004134:Dimyristoylphosphatidylcholine