A meta-analysis of interleukin-10-1082 promoter genetic polymorphism associated with atherosclerotic risk.
OBJECTIVE
This meta-analysis was conducted to assess the relationship between interleukin-10-1082 G/A single nucleotide polymorphism with atherosclerosis (AS) risk.


METHODS
The databases of PubMed, EMBASE, Chinese National Knowledge Infrastructure and Wan-Fang were searched from January 2000 to January 2014. 16 studies (involving 7779 cases and 7271 controls) were finally included. Each eligible study was scored for quality assessment. We adopted the most probably appropriate genetic model (recessive model) after carefully calculation. Between study heterogeneity was explored by subgroup analysis and publication bias was estimated by Begg's funnel plot and Egger's regression test.


RESULTS
Statistically significant association was observed between AA genotype with overall AS risk, being mainly in coronary heart disease and stroke subgroups among Asian population, and peripheral artery disease (PAD) subgroup among Caucasians.


CONCLUSIONS
Interleukin-10-1082 AA genotype is associated with increased overall AS risk. AA carriers of Asians seem to be more susceptible to coronary artery disease and stroke, and Caucasians are more susceptible to PAD.
Department of Cardiology, Ruijin Hospital Affiliated of Shanghai Jiao Tong University, Shanghai 200025, China.
Li
L
Chao
Huang
H
Lei
Jin
J
Fei
D044466:Asian People / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk
C508609:IL10 protein, human; D016753:Interleukin-10