Antibacterial effect of royal jelly for preservation of implant-related spinal infection in rat.
OBJECTIVE
Implant-related infections are still a significant problem in spinal surgical procedures. Many drugs and methods have been tried to prevent implant-related infections. Our objective in this study was to evaluate whether royal jelly, which was found to hinder the growth of MRSA, has any preventive role in the prognosis of an infection in rats in an implant-related infection model.


METHODS
Rats were divided into 3 groups of eight rats. Group-1 consisted of rats that underwent only a spinal implant, group-2 included those rats that were inoculated bacteria together with a spinal implant and group-3 was administered royal jelly in addition to a spinal implant and infection.


RESULTS
The amount of bacteria that grew in vertebral columns and implants was more in Group-2 than in Group-3, which meant that the number of bacteria colonies that grew was more quantitatively. This difference was found to be statistically significant in vertebral columns, but not in implants.


CONCLUSIONS
Royal jelly could not fully prevent the MRSA infection in this model, but decreased the severity of infection noticeably. More objective and promising results may be obtained if royal jelly can be used at regular intervals in a different model to be designed with respect to implant-related infections.
Bakirköy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, Department of Neurosurgery, Istanbul, Turkey.
Omur
O
Gunaldi
Yusuf Kenan
YK
Daglioglu
Bekir
B
Tugcu
Suna
S
Kizilyildirim
Lutfi
L
Postalci
Ender
E
Ofluoglu
Fatih
F
Koksal
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D017208:Rats, Wistar; D013122:Spinal Diseases / Q000188:drug therapy*; D000099219:Royal Jelly
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D000099219:Royal Jelly