An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta.
Hemerocallis fulva L. var. sempervirens M. Hotta (kwanso) represents an exceptional resource for identifying and developing new phytomedicines for the treatment and prevention of disease. The aim of this study was to conduct a detailed investigation of the biological activities of kwanso. Our study resulted in four major findings. First, kwanso scavenges hydroxyl radicals generated by H(2)O(2)/UV light system in vitro in a dose-dependent manner. Second, hepatic glutathione levels were significantly increased when kwanso was orally administered to mice. Third, the oral administration of kwanso to mice showed a tendency to suppress hepatic injury induced by acetaminophen. Finally, kwanso slightly inhibited cytochrome P450 3A activity. These results provide useful evidence in support of the development of kwanso as a candidate raw material for the treatment and prevention of disease.
a Faculty of Pharmaceutical Sciences, Sojo University , 4-22-1 Ikeda, Kumamoto 862-0082 , Japan.
Kazuaki
K
Taguchi
Keishi
K
Yamasaki
Hiroki
H
Maesaki
Masahiro
M
Tokuno
Shoko
S
Okazaki
Hiroshi
H
Moriuchi
Keizo
K
Takeshita
Masaki
M
Otagiri
Hakaru
H
Seo
D000284:Administration, Oral; D000818:Animals; D045424:Complex Mixtures; D065692:Cytochrome P-450 CYP3A Inhibitors / Q000494:pharmacology; D005978:Glutathione / Q000032:analysis; D031421:Hemerocallis / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008518:Medicine, East Asian Traditional; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
D045424:Complex Mixtures; D065692:Cytochrome P-450 CYP3A Inhibitors; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D005978:Glutathione
Hemerocallis fulva L. var. sempervirens M. Hotta; biological activity; oriental medicine