A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy.
Children's Cancer Centre, Royal Children's Hospital, Victoria, Australia.
Diane M T
DM
Hanna
Molecular Pathology Laboratory, Peter MacCallum Cancer Centre, Victoria, Australia.
Andrew
A
Fellowes
Molecular Pathology Laboratory, Peter MacCallum Cancer Centre, Victoria, Australia.
Ravikiran
R
Vedururu
Children's Cancer Centre, Royal Children's Hospital, Victoria, Australia.
Francoise
F
Mechinaud
Children's Cancer Centre, Royal Children's Hospital, Victoria, Australia jordan.hansford@rch.org.au.
Jordan R
JR
Hansford
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D003520:Cyclophosphamide; D004317:Doxorubicin; D019008:Drug Resistance, Neoplasm; D005047:Etoposide; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053616:Janus Kinase 3 / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008479:Mediastinal Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D009154:Mutation; D010880:Piperidines / Q000627:therapeutic use*; D011241:Prednisone; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous; D014750:Vincristine
D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; C479163:tofacitinib; D003520:Cyclophosphamide; C507933:JAK3 protein, human; D053616:Janus Kinase 3; D011241:Prednisone
JAK inhibitor; PMBCL; primary mediastinal B-cell lymphoma; refractory; tofacitinib