Novel gammaherpesvirus functions encoded by bovine herpesvirus 6 (bovine lymphotropic virus).
The genus Macavirus of the subfamily Gammaherpesvirinae includes viruses that infect lymphoid cells of domestic and wild ruminants and swine, causing asymptomatic latent infections in reservoir hosts. Here, we describe the genome of bovine herpesvirus 6 (BoHV-6), a macavirus ubiquitous in healthy cattle populations. The BoHV-6 genome exhibited architecture conserved in macaviruses, including a repetitive H-DNA region and unique 141 kbp L-DNA region predicted to encode 77 genes. BoHV-6 encoded, in variable genomic regions, a novel complement of genes relative to other characterized macaviruses, probably contributing to distinctive aspects of BoHV-6 infection biology and host range. Most notably, BoHV-6 encoded the first herpesviral protein (Bov2.b2) similar to cellular ornithine decarboxylase, an enzyme that catalyses the first and rate-limiting step in the biosynthesis of polyamines. Bov2.b2 conceivably mediates a novel mechanism by which BoHV-6 promotes cell-cycle-dependent viral replication.
Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.|Laboratory of Animal Infectious Disease and Microarray/Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Animal Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, PR China.
J
J
Jia
School of Veterinary Medicine & Biomedical Sciences and Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA.
G
G
Delhon
Department of Pathobiology and Veterinary Science and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, CT, USA.
E R
ER
Tulman
Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
D G
DG
Diel
School of Veterinary Medicine & Biomedical Sciences and Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA.
F A
FA
Osorio
Laboratory of Animal Infectious Disease and Microarray/Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Animal Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, PR China.
X
X
Wen
Department of Pathobiology and Veterinary Science and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, CT, USA.
G F
GF
Kutish
Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
D L
DL
Rock
D000818:Animals; D002417:Cattle; D004279:DNA, Viral / Q000737:chemistry* / Q000235:genetics*; D018142:Gammaherpesvirinae / Q000235:genetics* / Q000302:isolation & purification; D023061:Gene Order; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009955:Ornithine Decarboxylase / Q000235:genetics; D017422:Sequence Analysis, DNA; D026801:Synteny; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D014764:Viral Proteins; D009955:Ornithine Decarboxylase