Prediction of Young׳s modulus of trabeculae in microscale using macro-scale׳s relationships between bone density and mechanical properties.
According to the literature, there are many mathematical relationships between density of the trabecular bone and mechanical properties obtained in macro-scale testing. In micro-scale, the measurements provide only the ranges of Young׳s modulus of trabeculae, but there are no experimentally tested relationships allowing the calculation of the distribution of Young׳s modulus of trabeculae within these experimental ranges. This study examined the applicability of relationships between bone density and mechanical properties obtained in macro-scale testing for the calculation of Young׳s modulus distribution in micro-scale. Twelve cubic specimens from eleven femoral heads were cut out and micro-computed tomography (micro-CT) scanned. A mechanical compression test and Digital Image Correlation (DIC) measurements were performed to obtain the experimental displacement and strain full-field evaluation for each specimen. Five relationships between bone density and Young׳s modulus were selected for the test; those were given by Carter and Hayes (1977), Ciarelli et al. (2000), Kaneko et al. (2004), Keller (1994) for the human femur, and Li and Aspden, 1997. Using these relationships, five separate finite element (FE) models were prepared, with different distribution of Young׳s modulus of trabeculae for each specimen. In total, 60 FE analyses were carried out. The obtained displacement and strain full-field measurements from numerical calculations and experiment were compared. The results indicate that the highest accuracy of the numerical calculation was obtained for the Ciarelli et al. (2000) relationship, where the relative error was 17.87% for displacements and 50.94 % for strains. Therefore, the application of the Ciarelli et al. (2000) relationship in the microscale linear FE analysis is possible, but mainly to determine bone displacement.
X-ray Microtomography Lab, Department of Biomedical Computer Systems, Institute of Computer Science, Faculty of Computer and Materials Science, University of Silesia, 75 Pulku Piechoty 1, budynek H, segment C, pok. P7, 41-500 Chorzów, Poland.
Łukasz
Ł
Cyganik
X-ray Microtomography Lab, Department of Biomedical Computer Systems, Institute of Computer Science, Faculty of Computer and Materials Science, University of Silesia, 75 Pulku Piechoty 1, budynek H, segment C, pok. P7, 41-500 Chorzów, Poland. Electronic address: marcin.binkowski@us.edu.pl.
Marcin
M
Binkowski
Institute of Computational Mechanics and Engineering, Silesian University of Technology, ul. Konarskiego 18A, 44-100 Gliwice, Poland.
Grzegorz
G
Kokot
Elhys Sp. z o.o., MTS Systems Corporation Representative in Poland, ul. Naukowa 45, 02-463 Warszawa, Poland.
Tomasz
T
Rusin
X-ray Microtomography Lab, Department of Biomedical Computer Systems, Institute of Computer Science, Faculty of Computer and Materials Science, University of Silesia, 75 Pulku Piechoty 1, budynek H, segment C, pok. P7, 41-500 Chorzów, Poland.
Paulina
P
Popik
Medical College, Jagiellonian University, ul. Grzegórzecka 16, 31-531 Kraków, Poland.
Filip
F
Bolechała
Medical University of Silesia, School of Medicine with the Division of Dentistry, Chair and Department of Orthopaedics, WSS no. 5, ul. Medyków 1, 41-200 Sosnowiec, Poland.
Roman
R
Nowak
X-ray Microtomography Lab, Department of Biomedical Computer Systems, Institute of Computer Science, Faculty of Computer and Materials Science, University of Silesia, 75 Pulku Piechoty 1, budynek H, segment C, pok. P7, 41-500 Chorzów, Poland.
Zygmunt
Z
Wróbel
Institute of Computational Mechanics and Engineering, Silesian University of Technology, ul. Konarskiego 18A, 44-100 Gliwice, Poland.
Antoni
A
John
D015502:Absorptiometry, Photon / Q000379:methods*; D000368:Aged; D000465:Algorithms; D015519:Bone Density / Q000502:physiology*; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D005270:Femur Head / Q000000981:diagnostic imaging* / Q000502:physiology*; D006244:Hardness / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology; D016474:Weight-Bearing / Q000502:physiology
Bone mineral density; Digital Image Correlation; Micro-computed tomography; Microscale properties; Trabecular bone; Young׳s modulus