Meat, dairy, and cancer.
In 2007 the World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) report judged that the evidence for an association between red and processed meat consumption and colorectal cancer was convincing. In addition, the effect of other animal products on cancer risk has been studied, and the WCRF/AICR report concluded that milk probably decreases the risk of colorectal cancer but diets high in calcium probably increase the risk of prostate cancer, whereas there was limited evidence for an association between milk and bladder cancer and insufficient evidence for other cancers. There are several potential mechanisms relating meat to cancer, including heterocyclic amines, polycyclic aromatic hydrocarbons, N-nitroso compounds, and heme iron. Although the evidence in favor of a link between red and processed meat and colorectal cancer is convincing, the relations with other cancers are unclear. In this review, we summarize cohort studies conducted by the National Cancer Institute on meat and dairy intake in relation to cancer since the 2007 WCRF/AICR report. We also report the findings of meta-analyses published since 2007.
From the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD.
Zaynah
Z
Abid
From the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD.
Amanda J
AJ
Cross
From the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD.
Rashmi
R
Sinha
D000818:Animals; D002136:Calcium, Dietary / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000209:etiology / Q000517:prevention & control; D004032:Diet; D005247:Feeding Behavior; D006801:Humans; D008297:Male; D008460:Meat / Q000009:adverse effects*; D008892:Milk; D011471:Prostatic Neoplasms / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000209:etiology*
D002136:Calcium, Dietary