Work history and mortality risks in 90,268 US radiological technologists.
OBJECTIVE
There have been few studies of work history and mortality risks in medical radiation workers. We expanded by 11 years and more outcomes our previous study of mortality risks and work history, a proxy for radiation exposure.


METHODS
Using Cox proportional hazards models, we estimated mortality risks according to questionnaire work history responses from 1983 to 1989 through 2008 by 90,268 US radiological technologists. We controlled for potential confounding by age, birth year, smoking history, body mass index, race and gender.


RESULTS
There were 9566 deaths (3329 cancer and 3020 circulatory system diseases). Mortality risks increased significantly with earlier year began working for female breast (p trend=0.01) and stomach cancers (p trend=0.01), ischaemic heart (p trend=0.03) and cerebrovascular diseases (p trend=0.02). The significant trend with earlier year first worked was strongly apparent for breast cancer during baseline through 1997, but not 1998-2008. Risks were similar in the two periods for circulatory diseases. Radiological technologists working ≥5 years before 1950 had elevated mortality from breast cancer (HR=2.05, 95% CI 1.27 to 3.32), leukaemia (HR=2.57, 95% CI 0.96 to 6.68), ischaemic heart disease (HR=1.13, 95% CI 0.96 to 1.33) and cerebrovascular disease (HR=1.28, 95% CI 0.97 to 1.69). No other work history factors were consistently associated with mortality risks from specific cancers or circulatory diseases, or other conditions.


CONCLUSIONS
Radiological technologists who began working in early periods and for more years before 1950 had increased mortality from a few cancers and some circulatory system diseases, likely reflecting higher occupational radiation exposures in the earlier years.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Jason J
JJ
Liu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
D Michal
DM
Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Mark P
MP
Little
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Michele M
MM
Doody
Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Bruce H
BH
Alexander
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Cari M
CM
Kitahara
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Terrence
T
Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Preetha
P
Rajaraman
Information Management Services, Inc., Rockville, Maryland, USA.
Jeremy S
JS
Miller
Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Diane M
DM
Kampa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Steven L
SL
Simon
Hirosoft International, Eureka, California, USA.
Dale L
DL
Preston
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Martha S
MS
Linet
D000328:Adult; D000368:Aged; D000488:Allied Health Personnel; D002318:Cardiovascular Diseases / Q000401:mortality*; D004651:Employment; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009784:Occupational Diseases / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D016016:Proportional Hazards Models; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013679:Technology, Radiologic; D014937:Work
circulatory system diseases; mortality; neoplasms; radiologic technologists; work history