Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids.
A tailor-made colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids was developed by incorporating a coumarin-hemicyanine fluorophore into an isaindigotone framework. The significant and distinct changes in both the color and fluorescence of this probe enable the label-free and visual detection of G-quadruplex structures.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. tanjiah@mail.sysu.edu.cn ceshzs@mail.sysu.edu.cn.
Jin-Wu
JW
Yan
Shuo-Bin
SB
Chen
Hui-Yun
HY
Liu
Wen-Jie
WJ
Ye
Tian-Miao
TM
Ou
Jia-Heng
JH
Tan
Ding
D
Li
Lian-Quan
LQ
Gu
Zhi-Shu
ZS
Huang
D000470:Alkaloids / Q000737:chemistry*; D003124:Colorimetry / Q000379:methods*; D004247:DNA / Q000032:analysis*; D004275:DNA, Ribosomal / Q000032:analysis; D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry; D008175:Lung Neoplasms / Q000378:metabolism; D015394:Molecular Structure; D010750:Phosphoproteins / Q000378:metabolism; D011799:Quinazolines / Q000737:chemistry*; D016601:RNA-Binding Proteins / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D000097796:Nucleolin
D000470:Alkaloids; D004247:DNA; D004275:DNA, Ribosomal; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D010750:Phosphoproteins; D011799:Quinazolines; D016601:RNA-Binding Proteins; D000097796:Nucleolin; C440668:isaindigotone