Mixture of nonionic/ionic surfactants for the formulation of nanostructured lipid carriers: effects on physical properties.
The objective of the present work was to investigate the effects of the mixture of nonionic/ionic surfactants on nanostructured lipid carriers (NLCs). Nonionic surfactant (polyethylene-poly(propylene glycol), Pluronic F68) and ionic surfactant (octenylsuccinic acid modified gum arabic, GA-OSA) were chosen as emulsifier for NLCs. The NLCs systems, which were composed of lipid matrix, modified 4-dedimethylaminosancycline (CMT-8), and various emulsifier agents, were characterized with dynamic light scattering (DLS), high performance liquid chromatography (HPLC), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), in vitro release, and phagocytosis assay. This mixture of nonionic/ionic surfactants showed significant effects on physical properties including particle size, polydispersity index (PDI), entrapment efficiency, and particle morphology. Compared with single stabilizer, this mixed nonionic/ionic surfactant system provided NLCs with better drug carrier properties including prolonged release profile and low phagocytosis by phagocyte. We expect that these explorations can provide a new strategy for the development of lipid nanoparticles as drug delivery.
Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, East China University of Science and Technology , Shanghai 200237, P. R. China.
Shuangni
S
Zhao
Xiaomin
X
Yang
Vasil M
VM
Garamus
Ulrich A
UA
Handge
Luthringer
L
Bérengère
Lin
L
Zhao
Gabriele
G
Salamon
Regine
R
Willumeit
Aihua
A
Zou
Saijun
S
Fan
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D053838:Scattering, Small Angle; D013501:Surface-Active Agents / Q000737:chemistry*; D014961:X-Ray Diffraction
D004337:Drug Carriers; D008055:Lipids; D013501:Surface-Active Agents