Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation.
Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study the long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of "realized" solar radiation dose and UV-induced injury. We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. We will discuss its use as a topically-applied root-derived formulation of the Plectranthus barbatus (Coleus forskolii) plant that grows naturally in Asia and that has long been used in various Aryuvedic teas and therapeutic preparations.
The Graduate Center for Toxicology, the Markey Cancer Center and the Department of Pediatrics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA.
Alexandra
A
Amaro-Ortiz
The Graduate Center for Toxicology, the Markey Cancer Center and the Department of Pediatrics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA.
Betty
B
Yan
The Graduate Center for Toxicology, the Markey Cancer Center and the Department of Pediatrics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA. jdorazio@uky.edu.
John A
JA
D'Orazio
D000287:Administration, Topical; D000375:Aging / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D000242:Cyclic AMP / Q000378:metabolism*; D004249:DNA Damage / Q000528:radiation effects; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D031346:Plectranthus / Q000737:chemistry; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014466:Ultraviolet Rays
D010936:Plant Extracts; D000242:Cyclic AMP