Modulating aβ33-42 peptide assembly by graphene oxide.
Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (Aβ33-42 ). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene-based materials to inhibit amyloidosis.
Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690.
Qiang
Q
Li
Lei
L
Liu
Shuai
S
Zhang
Meng
M
Xu
Xueqin
X
Wang
Chen
C
Wang
Flemming
F
Besenbacher
Mingdong
M
Dong
D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides; D000686:Amyloidosis / Q000378:metabolism*; D006108:Graphite; D018625:Microscopy, Atomic Force; D010455:Peptides
D000682:Amyloid; D016229:Amyloid beta-Peptides; D010455:Peptides; D006108:Graphite
amyloid peptides; assembly; graphene oxide; modulated structures