Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus.
We present a report of what we believe was an extremely rare case of hyperacute respiratory failure caused by first time exposure to cyclophosphamide in a 40-year-old woman with systemic lupus erythematosus. The patient was extensively evaluated for alternative etiologies with negative results. Treatment with methylprednisolone and high doses of human immunoglobulin resulted in gradual improvement of the patient's condition. We review the literature with regard to cyclophosphamide-induced lung toxicity.
Department of Nephrology, Aalborg University Hospital, Mølleparkvej 4, 9000, Aalborg, Denmark, pschjelderup@gmail.com.
P
P
Schjelderup
T C
TC
El-Galaly
J B
JB
Frøkjær
T
T
Ring
D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007261:Infusions, Intra-Arterial; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy*; D008775:Methylprednisolone / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control*; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D007136:Immunoglobulins; D003520:Cyclophosphamide; D008775:Methylprednisolone