Magnetophoretic circuits for digital control of single particles and cells.
The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.
1] Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Republic of Korea [2] School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea [3].
Byeonghwa
B
Lim
1] Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Republic of Korea [2] School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea [3].
Venu
V
Reddy
1] Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Republic of Korea [2] School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea.
XingHao
X
Hu
1] Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Republic of Korea [2] School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea.
KunWoo
K
Kim
School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea.
Mital
M
Jadhav
1] Department of Mechanical Engineering and Materials Science, Duke University, Box 90300 Hudson Hall, Durham, North Carolina 27708, USA [2] University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Roozbeh
R
Abedini-Nassab
School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea.
Young-Woock
YW
Noh
SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Yong Taik
YT
Lim
1] Department of Mechanical Engineering and Materials Science, Duke University, Box 90300 Hudson Hall, Durham, North Carolina 27708, USA [2] University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Benjamin B
BB
Yellen
1] Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Republic of Korea [2] School of Engineering, Chungnam National University, Daejeon 305-764, Republic of Korea.
CheolGi
C
Kim
D003102:Colloids; D003201:Computers; D057446:Hydrodynamics; D059346:Magnets; D053758:Nanoparticles; D059010:Single-Cell Analysis / Q000295:instrumentation / Q000379:methods*
D003102:Colloids