Overcoming psychosocial and developmental barriers to blood and marrow transplantation (BMT) in an adolescent/young adult (AYA) transgender patient with chronic myelogenous leukemia.
Adolescents/young adults (AYAs) afflicted with cancer face unique barriers to potentially standard curative therapies, such as blood and marrow transplantation (BMT). Transgender AYAs face additional barriers and there is a dearth of published literature regarding their oncology-related experience. We present the case of an AYA male-to-female (MTF) transgender patient on cross-sex hormone therapy, with a history of Chronic Myelogenous Leukemia (CML) and significant psychosocial barriers, which initially served as a barrier to BMT at two different centers; we modified our standard consent and education process and was able to successfully proceed with BMT and subsequently cure her CML. Despite unique challenges, AYA and transgender patients with significant psychosocial barriers may achieve successful outcomes with BMT. Research is needed regarding guidelines for cross-sex hormone therapy administration for patients undergoing BMT and other issues, which may be unique to the transgender experience.
Department of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Sajad
S
Khazal
Hisham
H
Abdel-Azim
Neena
N
Kapoor
Kris M
KM
Mahadeo
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000523:psychology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage; D006086:Graft vs Host Disease / Q000523:psychology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000523:psychology / Q000628:therapy*; D008297:Male; D010349:Patient Compliance / Q000523:psychology; D010353:Patient Education as Topic; D011584:Psychology; D011788:Quality of Life / Q000523:psychology; D012917:Social Adjustment; D063508:Social Discrimination / Q000523:psychology; D063106:Transgender Persons / Q000523:psychology*; D019172:Transplantation Conditioning; D016896:Treatment Outcome; D055815:Young Adult
D012739:Gonadal Steroid Hormones
adolescent/young adult (AYA); barriers; blood and marrow transplant (BMT); cancer; psychosocial; transgender