Association between skeletal muscle mass and radial augmentation index in an elderly Korean population.
Increasing evidence supports the importance of maintaining skeletal muscle mass for cardiovascular health. However, there is limited data on the relationship between skeletal muscle mass and arterial stiffness targeting an elderly population. Thus, we investigated the association between skeletal muscle mass and arterial stiffness in an elderly Korean population. This study used data from the Korean Social Life, Health and Aging Project which started in 2011. In this cross-sectional study, 180 men (mean age 71.7) and 247 women (mean age 70.9) were included. Arm and leg muscle masses were measured by bioelectrical impedance analysis. Radial augmentation index, a noninvasive measure of arterial stiffness, was assessed by radial pulse wave analysis. The relationship between skeletal muscle mass and augmentation index was investigated by multiple linear regression analysis. In men, limb muscle mass was significantly and inversely associated with augmentation index (β=-1.07% per 1 kg muscle mass, p<0.001) when adjusted for age. This inverse association remained after additional adjustment for body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein-cholesterol, fasting glucose, insulin, smoking and alcohol intake (β=-0.69%, p=0.019). In women, the inverse association between limb muscle mass and augmentation index was less prominent (β=-0.59%, p=0.030), and the association disappeared when fully adjusted (β=-0.32%, p=0.304). However, limb muscle mass was not associated with resting blood pressure either in men or women. Our results suggest that decreased skeletal muscle mass may affect arterial wall elasticity.
Department of Public Health, Yonsei University Graduate School, Seoul, Republic of Korea; Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
Seung Won
SW
Lee
Department of Sociology, Yonsei University College of Social Sciences, Seoul, Republic of Korea. Electronic address: yoosik@yonsei.ac.kr.
Yoosik
Y
Youm
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Chang Oh
CO
Kim
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Won Joon
WJ
Lee
Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.
Wungrak
W
Choi
Department of Clinical Nursing Science, Yonsei University College of Nursing, Seoul, Republic of Korea.
Sang Hui
SH
Chu
Division of Silver Industry, Kangnam University, Yongin, Republic of Korea.
Yeong-Ran
YR
Park
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: hckim@yuhs.ac.
Hyeon Chang
HC
Kim
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D001795:Blood Pressure Determination; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000033:anatomy & histology*; D056910:Republic of Korea; D012307:Risk Factors; D055948:Sarcopenia / Q000503:physiopathology*; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013599:Systole / Q000502:physiology*; D059289:Vascular Stiffness
D015415:Biomarkers
Arterial stiffness; Augmentation index; Elderly; Korea; Muscle mass; Sarcopenia