Black pigmented aortic valve and sinus of Valsalva caused by life-long minocycline therapy.
Minocycline, a derivative of tetracycline, is a broad-spectrum antibiotic used in the treatment of various infections. Black discolouration of the skin, teeth, bones and the thyroid gland are sequelae of long-term minocycline therapy. We report an unusual case of minocycline-induced pigmentation of the aortic valve and sinuses of Valsalva.
Division of Cardiovascular and Thoracic Surgery, Intermountain Medical Center, Murray, UT, USA ttsune0707@hotmail.co.jp.
Tomohiro
T
Tsunekawa
Division of Cardiovascular and Thoracic Surgery, Intermountain Medical Center, Murray, UT, USA.
Kent W
KW
Jones
Division of Cardiovascular and Thoracic Surgery, Intermountain Medical Center, Murray, UT, USA.
John R
JR
Doty
D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001018:Aortic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D001021:Aortic Valve / Q000187:drug effects* / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000601:surgery; D001706:Biopsy; D004334:Drug Administration Schedule; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D019918:Heart Valve Prosthesis Implantation; D016575:Hidradenitis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D010858:Pigmentation / Q000187:drug effects*; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000175:diagnosis; D012850:Sinus of Valsalva / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D008911:Minocycline
Aortic valve; Heart valve disease; Surgery