Hypomania soon after shifting from paroxetine to agomelatine in a middle-aged woman with depression.
Hypomania or mania has been reported to be induced by multiple classes of antidepressant agents. Agomelatine is a newly approved drug for treating major depression, and its antidepressant effect works through distinct pharmacodynamic mechanisms from most other commonly used antidepressants. Here, we report a middle-aged female patient who presented hypomanic symptoms shortly after shifting from paroxetine to agomelatine.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital; and College of Medicine, Chang Gung University, Kaohsiung, Taiwan.
Kun-Yu
KY
Tu
Pao-Yen
PY
Lin
D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003527:Cyclothymic Disorder / Q000139:chemically induced* / Q000517:prevention & control; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D016903:Drug Monitoring; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D016584:Panic Disorder / Q000523:psychology; D017374:Paroxetine / Q000627:therapeutic use; D044094:Receptors, Melatonin / Q000819:agonists*; D012008:Recurrence; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D014196:Trazodone / Q000627:therapeutic use; D016896:Treatment Outcome; D009281:Naphthalenes
D000081:Acetamides; D000928:Antidepressive Agents; D017374:Paroxetine; D044094:Receptors, Melatonin; D058830:Serotonin 5-HT2 Receptor Antagonists; D014196:Trazodone; C084711:agomelatine; D009281:Naphthalenes