Intra-abdominal penetration and pharmacodynamic exposure to fluconazole in three liver transplant patients with deep-seated candidiasis.
Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy pea.federico@aoud.sanita.fvg.it.
Federico
F
Pea
Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy.
Elda
E
Righi
Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
Piergiorgio
P
Cojutti
Clinic of Internal Medicine-Liver Unit, Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
Alessia
A
Carnelutti
Department of Medical and Biological Sciences, University of Udine, Udine, Italy.
Umberto
U
Baccarani
Clinic of Internal Medicine-Liver Unit, Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
Giorgio
G
Soardo
Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy.
Matteo
M
Bassetti
D061605:Administration, Intravenous; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001201:Ascites; D001646:Bile / Q000737:chemistry; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy*; D015725:Fluconazole / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D016867:Immunocompromised Host; D016031:Liver Transplantation / Q000009:adverse effects; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010538:Peritonitis / Q000175:diagnosis / Q000188:drug therapy*; D010949:Plasma / Q000737:chemistry; D066027:Transplant Recipients
D000935:Antifungal Agents; D015725:Fluconazole
ascites; bile; pharmacokinetic/pharmacodynamic