Prevalence of antibodies against transfusion-transmissible infections (TTI) in blood donors from the Colombian eastern region.
BACKGROUND
The main purpose of this study was to establish the prevalence of antibodies against five transfusion-transmissible infections (TTIs) in blood donors from one of the most important blood banks in Colombia.


METHODS
A cross-sectional, descriptive and case control study was performed from a database of Higuera-Escalante blood bank, for a period of a year. Serum was used for donor screening. Surface antigens for hepatitis B (HbsAg), anti-hepatitis C antibodies, Chagas disease, syphilis, and HIV were identified. Chemiluminescent Microparticle Immunoassay (CMIA, Abbott Diagnostics) was performed.


RESULTS
From 41,575 total donors analyzed, 1,226 were reactive for any of the infectious markers (total prevalence of 2.95%). The prevalence of specific infections was: Chagas disease 0.49%, HbsAg 0.21%, HCV 0.45%, HIV 0.12%, and syphilis 1.68%. Reactivity was more frequent in men (n = 785, 64%) with a mean age of 36.35 years. HIV was present in the youngest donors with a mean age of 26.5 years (IC 95%: 23.6 - 27.6); on the other hand, Chagas disease was found in the oldest donor population, with a mean age of 40 years (IC 95%: 39.1 - 41.3).


CONCLUSIONS
Identifying the prevalence of circulating antibodies against transfusion transmissible infections allows us to establish an epidemiological profile of donors inhabiting the geographic catchment area of our blood bank. Total prevalence in this study was 2.95% for any of the five markers. Syphilis prevalence demonstrates its high distribution within the blood donor population of our country, although this result could be influenced by the high rate of false-reactive test. Chagas disease is endemic in Santander, Colombia, which correlates with the results obtained in this study.
Lina Andrea
LA
Gómez
Oscar
O
Peñuela
Fernando
F
Higuera
D000328:Adult; D000906:Antibodies / Q000009:adverse effects* / Q000097:blood*; D000913:Antibodies, Protozoan / Q000097:blood; D001782:Blood Donors / Q000706:statistics & numerical data / Q000600:supply & distribution; D017848:Blood-Borne Pathogens; D016022:Case-Control Studies; D003105:Colombia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D018562:Disease Transmission, Infectious / Q000706:statistics & numerical data; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D065227:Transfusion Reaction; D014208:Treponema / Q000276:immunology / Q000472:pathogenicity; D014349:Trypanosoma cruzi / Q000276:immunology / Q000472:pathogenicity; D055815:Young Adult
D000906:Antibodies; D000913:Antibodies, Protozoan; D015483:HIV Antibodies; D006508:Hepatitis Antibodies