Metabonomics exposes metabolic biomarkers of Crohn's disease by (1)HNMR.
Metabonomics and other "omics" fields are essential science in analytical chemistry. Modern analytical instruments such as proton nuclear magnetic resonance ((1)H NMR) can be provided the great quantity of analytical information. In order to assign unknown samples, chemometrics methods recognition build classification model based on experimental data. Firstly some current strategies for regarding disease diagnosis are exhibited in metabonomics studies. Some disease such as crohn's disease can be difficult to diagnosis since its signs and symptoms may be similar to other medical problems or often mimic other symptoms. Applications of NMR and supervised pattern recognition in the field of metabonomics are also reviewed in recent years. The aim of present study was to review the assessment of (1)HNMR to investigate a metabolic profile of crohn's disease.
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Fariba
F
Fathi
Department of Chemistry, Tarbiat Modares University, Tehran, Iran.
Fatemeh
F
Ektefa
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehrdad
M
Hagh-Azali
Basic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamid Asadzadeh
HA
Aghdaie
1HNMR; Chemometrics; Crohn disease; Metabonomics