A case of metastatic gastric neuroendocrine tumor: therapeutic considerations.
Despite remarkable progression in the treatment and classification system of neuroendocrine tumor (NET), some questions have remained unanswered. The lack of an established treatment strategy for gastric NET is one of the problems. Because of its paucity, gastric NET is not discussed in independent, large-scaled prospective studies and tends to be excluded from clinical trials. Moreover, a separate classification system and some distinguished clinical features render the treatment of gastric NET more complicated. Here, we present a case of a female gastric NET patient with G2 proliferation index and multiple liver metastases. Based on the histologic grade and a high serum gastrin level, we initially treated her with somatostatin analogue. However, the patient did not respond. After that, cytotoxic chemotherapy with the etoposide plus cisplatin regimen only showed response in the short-term period. However, combination therapy with octreotide and interferon brought about significant regression of the tumor. Herein, we present our case together with a literature review of the treatment of metastatic gastric NET.
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
Shin Young
SY
Kim
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
In Sook
IS
Woo
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
Ji Hyun
JH
Yang
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
Chi Wha
CW
Han
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
Sang Young
SY
Roh
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
Yun Hwa
YH
Jung
Neuroendocrine tumor; Stomach; Therapy