Association of matrix metalloproteinase-11 polymorphisms with susceptibility and clinicopathologic characteristics for oral squamous cell carcinoma.
BACKGROUND
The purpose of this study was to investigate the influence of genetic polymorphisms of the matrix metalloproteinase-11 (MMP-11) gene on the susceptibility of oral squamous cell carcinoma (OSCC).


METHODS
Four single-nucleotide polymorphisms (SNPs) of the MMP-11 gene from 595 patients with oral cancer and 561 noncancer controls were analyzed by real-time polymerase chain reaction (PCR).


RESULTS
MMP-11 gene polymorphisms exhibit synergistic effects of environmental factors (betel nut chewing and tobacco use) on the susceptibility of OSCC. Furthermore, among patients with OSCC with betel nut consumption, those who have at least one polymorphic C allele of MMP-11 rs738792 have an increased incidence of lymph node metastasis when compared with those patients homozygous for T/T.


CONCLUSIONS
Our results showed that the combined effects of the MMP-11 gene polymorphisms and environmental carcinogens are related to an increased risk for the development of OSCC and may be a predictive factor for tumor lymph node metastasis in Taiwanese with OSCC.
Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.|Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chiao-Wen
CW
Lin
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Shun-Fa
SF
Yang
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chun-Yi
CY
Chuang
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Huang-Pin
HP
Lin
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chung-Han
CH
Hsin
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D053507:Matrix Metalloproteinase 11 / Q000235:genetics*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
C511771:MMP11 protein, human; D053507:Matrix Metalloproteinase 11
genetic polymorphism; matrix metalloproteinase-11 (MMP-11); oral cancer