Vitamin D fortified bread improves pain and physical function domains of quality of life in nursing home residents.
Nursing home residents have severe vitamin D deficiency and increased risk of falls and fractures. These individuals may need 125 μg of vitamin D3 to achieve desirable 25-hydroxyvitamin D [25(OH)D] concentrations to improve overall health. We evaluated health-related quality of life (HRQoL) in 45 nursing home residents (28 women and 17 men, aged 58-89 years) with 25(OH)D concentrations <50 nM who consumed daily one bun that had been fortified with 125 μg vitamin D3. The Romanian version of Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) was applied at baseline and after 12 months. Data were analyzed using repeated measures analyses of variance (ANOVA). After one year supplementation, serum 25(OH)D reached optimal status (>75 nM) and bone health has improved significantly. Nursing home residents who consumed daily bread fortified with 125 μg vitamin D3 reported significant (P=.02 for the effect of time) improvement in HRQoL (total score of QUALEFFO-41). The interaction time x treatment was also statistically significant on pain (P=.04), daily activities (P=.02), and locomotion (P=.04). To ensure the serum concentrations of 25(OH)D recommended by medical groups for bone- and general-health in the older nursing residents, the practical experience shows that much higher amounts of vitamin D3 are required. Fortification of bread and cereals is a feasible way to improve vitamin D nutrition.
1 Department of Endocrinology, Grigore T. Popa University of Medicine and Pharmacy , Iasi, Romania .
Anca Roxana
AR
Costan
Carmen
C
Vulpoi
Veronica
V
Mocanu
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001939:Bread; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002762:Cholecalciferol / Q000008:administration & dosage*; D005260:Female; D005527:Food, Fortified; D016330:Frail Elderly; D006801:Humans; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control; D058866:Osteoporotic Fractures / Q000517:prevention & control; D010146:Pain; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000503:physiopathology
D002136:Calcium, Dietary; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D
bread fortification; nursing home resident; pain; quality of life; vertebral fracture; vitamin D deficiency; vitamin D fortification