Polybrominated diphenyl ether (PBDE) exposure in children: possible associations with cardiovascular and psychological functions.
BACKGROUND
Polybrominated diphenyl ethers (PBDE) have been used widely in consumer products and are currently found at detectable levels in the blood of humans and animals across the globe. In stark contrast to this widespread exposure to PBDEs, there is relatively little research on potential adverse health effects of exposure of children to these chemicals.


OBJECTIVE
We performed this cross-sectional study to determine if blood PBDE levels (for 4 congeners) are associated with cardiovascular stress responses and psychological states in children.


METHODS
Levels of 4 PBDE congeners (BDE-28, -47, -99, and -100) in whole blood were measured in children (N=43). These levels were analyzed in relation to cardiovascular disease risk factors, including cardiovascular responses to acute stress and relevant psychological variables, namely, hostility and depression.


RESULTS
Higher levels of blood PBDEs were associated with significantly greater sympathetic activation during acute psychological stress and greater anger, as evidenced by significant associations with 3 different measures of this psychological variable.


CONCLUSIONS
This study suggests an association between PBDE exposure and children's cardiovascular responses to stress as well as parental and self-reported anger in the child. These variables are particularly important as they may be of potential relevance to the future development of cardiovascular disease (CVD). Although intriguing, there is a need for further investigation and replication with a larger sample of children.
Department of Public Health, Food Studies, and Nutrition, Syracuse University, Syracuse NY 13244, USA. Electronic address: bbgump@syr.edu.
Brooks B
BB
Gump
Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, School of Public Health, State University of New York, Albany, N Y 12201-0509, USA.
Sehun
S
Yun
Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, School of Public Health, State University of New York, Albany, N Y 12201-0509, USA; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Kurunthachalam
K
Kannan
D000786:Anger / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D002648:Child; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000097:blood / Q000633:toxicity*; D006334:Heart Function Tests; D006791:Hostility; D006801:Humans; D008297:Male; D013315:Stress, Psychological; D013647:Task Performance and Analysis
D055768:Halogenated Diphenyl Ethers; C086401:pentabromodiphenyl ether
Children; Hostility; PBDE; Polybrominated diphenyl ether; Stress; Sympathetic reactivity