γ-Globulin fraction proteins and their metal complexes with copper cations in induction of IL-8 production.
Plasma γ-globulin fraction proteins, copper cations, and metal complexes formed by copper cations with human serum γ-globulin induce the production of up to 4.0 ng/ml IL-8 by human blood cells. Protein modified by copper cations is 1.3-1.7-fold (p < 0.001-0.01) more potent than control γ-globulin and 1.3-fold (p < 0.001) more potent than copper cations alone. Analysis of the time course of IL-8 production demonstrated that IL-8 is produced as a prolonged or delayed response cytokine under conditions of this induction.
Laboratory of Cell-Cell Interactions, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow, Russia.
M A
MA
Apresova
I E
IE
Efremova
A A
AA
Babayants
S B
SB
Cheknev
D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism*; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005719:gamma-Globulins / Q000737:chemistry*
D016209:Interleukin-8; D046911:Macromolecular Substances; D005719:gamma-Globulins; D003300:Copper