Pancreatic Cancer Database: an integrative resource for pancreatic cancer.
Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.
Institute of Bioinformatics; International Technology Park; Bangalore, India; Amrita School of Biotechnology; Amrita Vishwa Vidyapeetham; Kollam, Kerala India.
Joji Kurian
JK
Thomas
McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Biological Chemistry; Johns Hopkins University School of Medicine; Baltimore, MD USA.
Min-Sik
MS
Kim
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Lavanya
L
Balakrishnan
Institute of Bioinformatics; International Technology Park; Bangalore, India; Amrita School of Biotechnology; Amrita Vishwa Vidyapeetham; Kollam, Kerala India.
Vishalakshi
V
Nanjappa
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Rajesh
R
Raju
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Arivusudar
A
Marimuthu
Institute of Bioinformatics; International Technology Park; Bangalore, India; Department of Biochemistry and Molecular Biology; School of Life Sciences; Pondicherry University; Puducherry, India.
Aneesha
A
Radhakrishnan
Institute of Bioinformatics; International Technology Park; Bangalore, India; Bioinformatics Centre; School of Life Sciences; Pondicherry University; Puducherry, India.
Babylakshmi
B
Muthusamy
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Aafaque Ahmad
AA
Khan
McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA.
Sruthi
S
Sakamuri
Armed Forces Medical College; Pune, India.
Shantal Gupta
SG
Tankala
Government Medical College and Hospital; Chandigarh, India.
Mukul
M
Singal
Amrita School of Biotechnology; Amrita Vishwa Vidyapeetham; Kollam, Kerala India.
Bipin
B
Nair
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Ravi
R
Sirdeshmukh
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Aditi
A
Chatterjee
Institute of Bioinformatics; International Technology Park; Bangalore, India; Amrita School of Biotechnology; Amrita Vishwa Vidyapeetham; Kollam, Kerala India.
T S Keshava
TS
Prasad
Departments of Pathology and Translational Molecular Pathology; Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research; UT MD Anderson Cancer Center; Houston, TX USA.
Anirban
A
Maitra
Institute of Bioinformatics; International Technology Park; Bangalore, India.
Harsha
H
Gowda
Department of Pathology; Sol Goldman Pancreatic Cancer Research Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA.
Ralph H
RH
Hruban
McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Biological Chemistry; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Pathology; Sol Goldman Pancreatic Cancer Research Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA.
Akhilesh
A
Pandey
D030541:Databases, Genetic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics
D035683:MicroRNAs; D011506:Proteins; D012333:RNA, Messenger
biomarker; body fluids; chronic pancreatitis; secreted