Targeted immunotherapy for non-small cell lung cancer.
Targeted therapies that deliver the expected anti-tumor effects while mitigating the adverse effects are taking the cancer world by storm. The need for such therapies in non-small cell lung cancer (NSCLC), where systemic cytotoxic chemotherapies still remain the backbone of management, is felt more than ever before. Runway success of immunotherapies such as Ipilimumab for melanoma has brought excitement among oncologists. Immune-based treatments are in various stages of evaluation for NSCLC as well. Immunotherapies using strategies of antigen based or cell based vaccines, and blocking immune checkpoints are of substantial interest. Meaningful clinical responses are yet to be reaped from these new treatment modalities.
Monali Vasekar, Xin Liu, Hong Zheng, Chandra P Belani, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States.
Monali
M
Vasekar
Monali Vasekar, Xin Liu, Hong Zheng, Chandra P Belani, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States.
Xin
X
Liu
Monali Vasekar, Xin Liu, Hong Zheng, Chandra P Belani, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States.
Hong
H
Zheng
Monali Vasekar, Xin Liu, Hong Zheng, Chandra P Belani, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States.
Chandra P
CP
Belani
Cytotoxic T-Lymphocyte Antigen-4; Immunotherapy; Non-small cell lung cancer; Programmed death ligands 1; Programmed death-1