Bacteria exploit platelets.
In this issue of Blood, Arman et al show that bacteria use immunoglobulin G (IgG) from plasma to engage platelet surface receptors FcγRIIA and integrin αIIbβ3 to induce platelet activation, which is further facilitated by platelet factor 4 (PF4).
UNIVERSITY OF DELAWARE.
Ulhas P
http://orcid.org/0000-0001-7556-444X
UP
Naik
D000818:Animals; D001792:Blood Platelets / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D010978:Platelet Factor 4 / Q000276:immunology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology*; D013211:Staphylococcus aureus / Q000502:physiology*; D013291:Streptococcus / Q000502:physiology*
C080568:Fc gamma receptor IIA; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D017452:Receptors, IgG; D010978:Platelet Factor 4