Methylenetetrahydrofolate reductase 677 genotype-specific reference values for plasma homocysteine and serum folate concentrations in korean population aged 45 to 74 years: the Namwon study.
The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (µM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea.
Department of Preventive Medicine, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea. ; Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Vanderbilt University School of Medicine, Nashville, TN, USA.
Sun-Seog
0000-0003-2378-8550
SS
Kweon
Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
Young-Hoon
0000-0003-1367-025X
YH
Lee
Department of Neurology, Chonbuk National University Medical School and Hospital, Jeonju, Korea.
Seul-Ki
0000-0002-9868-621X
SK
Jeong
Department of Preventive Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
Hae-Sung
0000-0003-0911-4576
HS
Nam
Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea.
Kyeong-Soo
0000-0001-8838-4894
KS
Park
Department of Preventive Medicine, Chosun University Medical School, Gwangju, Korea.
Seong-Woo
0000-0002-6150-3934
SW
Choi
Department of Food & Nutrition, Chosun University College of Natural Sciences, Gwangju, Korea.
Bok-Hee
0000-0002-9762-0948
BH
Kim
Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
Hee Nam
0000-0002-6153-2612
HN
Kim
Department of Preventive Medicine, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
Jin-Su
0000-0001-9001-0365
JS
Choi
Department of Preventive Medicine, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
Min-Ho
0000-0002-2217-5624
MH
Shin
D000367:Age Factors; D000368:Aged; D000375:Aging; D015331:Cohort Studies; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D012016:Reference Values; D056910:Republic of Korea; D012737:Sex Factors
D006710:Homocysteine; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
Aged Population; Folic Acid; Homocysteine; Reference Intervals