Hepatitis B virus genetic mutations and evolution in liver diseases.
Hepatitis B virus (HBV) belongs to the genus Orthohepadnavirus of the Hepadnaviridae family and is approximately 3.2 kb in length. Owing to a lack of proofreading capacity during reverse transcription and a high replication rate, HBV exhibits as quasispecies. To detect the genetic mutations of HBV, many methods with different sensitivities and throughputs were developed. According to documentary records, HBV mutation and evolution were important vial parameters in predicting disease progression and therapeutic outcome. In this review, we separately discussed the correlation between HBV genomic mutations in four open reading frames and liver disease progression. Since some of the results were controversial from different laboratories, it remains to be seen whether functional analyses will confirm their role in modifying the course of infection.
Tao Shen, Xin-Min Yan, Institute of Basic and Clinical Medicine, Center of Clinical Molecular Biology, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kumning Science and Technology University, Kunming 650032, Yunnan Province, China.
Tao
T
Shen
Tao Shen, Xin-Min Yan, Institute of Basic and Clinical Medicine, Center of Clinical Molecular Biology, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kumning Science and Technology University, Kunming 650032, Yunnan Province, China.
Xin-Min
XM
Yan
D000818:Animals; D018450:Disease Progression; D005838:Genotype; D006509:Hepatitis B / Q000175:diagnosis / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D009154:Mutation; D016366:Open Reading Frames; D010641:Phenotype; D014764:Viral Proteins / Q000235:genetics*
D014764:Viral Proteins
Genotype; Hepatitis B virus; Liver disease; Mutation; Risk markers