The SNP rs1883832 in CD40 gene and risk of atherosclerosis in Chinese population: a meta-analysis.
BACKGROUND
The complications of atherosclerosis such as coronary and cerebrovascular disease, are the most prevalent causes of mortality and morbidity worldwide. A single nucleotide polymorphism (SNP) rs1883832 (-1C/T) in CD40 gene has been recently suggested to contribute to the susceptibility to atherosclerosis in Chinese population; however, previous genetic association studies yielded inconsistent results.


METHODS
A meta-analysis of eligible studies reporting the association between rs1883832 and atherosclerosis in Chinese population was carried out.


RESULTS
Pooling 7 eligible case-control studies involving 2129 patients and 1895 controls demonstrated a significant association between rs1883832 and atherosclerosis under dominant model [odds ratio (OR) = 1.631, 95% confidence interval [CI] [1.176, 2.260] in Chinese population with evident heterogeneity. Meta-regression analysis indicated that the heterogeneity could be completely explained by disease category. In subgroup analysis, rs1883832 conferred ORs of 2.866 (C/C versus T/T, 95%CI [2.203, 3.729]) and 1.680 (C/T versus T/T, 95%CI [1.352, 2.086]) for coronary artery disease (CAD) under co-dominant model without heterogeneity. Similar results were obtained for acute coronary syndrome (ACS) (C/C versus T/T, 3.674, 95%CI [2.638, 5.116]; C/T versus T/T, 1.981, 95%CI [1.483, 2.646]). The other genetic models including dominant, recessive and additive models, yielded consistent results without heterogeneity for CAD and ACS, respectively. However, a protective role was found for C allele in ischemic stroke (IS) under recessive model (0.582, 95%CI [0.393, 0.864]) and additive model (0.785, 95%CI [0.679, 0.909]) with reduced heterogeneity.


CONCLUSIONS
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
School of Medicine, Shandong University, Ji'nan, Shandong, People's Republic of China.
Yan
Y
Yun
School of Medicine, Shandong University, Ji'nan, Shandong, People's Republic of China.
Chi
C
Ma
School of Medicine, Shandong University, Ji'nan, Shandong, People's Republic of China.
XiaoChun
X
Ma
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D050197:Atherosclerosis / Q000235:genetics*; D019013:CD40 Antigens / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011153:Population / Q000235:genetics*; D012306:Risk
D019013:CD40 Antigens