A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh.
OBJECTIVE
To evaluate the dose-response relationship between arsenic (As) exposure and markers of oxidative damage in Bangladeshi adults.


METHODS
We recruited 378 participants drinking water from wells assigned to five water As exposure categories; the distribution of subjects was as follows: (1) less than 10 μg/L (n=76); (2) 10 to 100 μg/L (n=104); (3) 101 to 200 μg/L (n=86); (4) 201 to 300 μg/L (n=67); and (5) more than 300 μg/L (n=45). Arsenic concentrations were measured in well water, as well as in urine and blood. Urinary 8-oxo-2'-deoxyguanosine and plasma protein carbonyls were measured to assess oxidative damage.


RESULTS
None of our measures of As exposure were significantly associated with protein carbonyl or 8-oxo-2'-deoxyguanosine levels.


CONCLUSIONS
We found no evidence to support a significant relationship between long-term exposure to As-contaminated drinking water and biomarkers of oxidative damage among Bangladeshi adults.
From the Departments of Environmental Health Sciences (Dr Harper, Ms Ilievski, Ms Oka, Ms Calancie, Ms Slavkovich, Dr Graziano, and Dr Gamble), Biostatistics (Dr Liu and Ms Levy), and Epidemiology (Dr Hall), Mailman School of Public Health, Columbia University, New York, NY; Columbia University Arsenic Project in Bangladesh (Mr Siddique and Mr Alam), Dhaka, Bangladesh; Lamont-Doherty Earth Observatory (Dr Mey and Dr van Geen), Columbia University, Palisades, NY; and Kingsbridge Community College (Dr Mey), New York, NY.
Kristin N
KN
Harper
Xinhua
X
Liu
Megan N
MN
Hall
Vesna
V
Ilievski
Julie
J
Oka
Larissa
L
Calancie
Vesna
V
Slavkovich
Diane
D
Levy
Abu
A
Siddique
Shafiul
S
Alam
Jacob L
JL
Mey
Alexander
A
van Geen
Joseph H
JH
Graziano
Mary V
MV
Gamble
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D001151:Arsenic / Q000009:adverse effects* / Q000378:metabolism; D001459:Bangladesh; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D050050:Protein Carbonylation; D014877:Water Pollution, Chemical
D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D001151:Arsenic