CD90 expression in atypical meningiomas and meningioma metastasis.
OBJECTIVE
Meningiomas are slow-growing intracranial/intraspinal tumors, with a wide range of histopathologic variants. The more aggressive atypical and malignant types can disseminate via the venous system, lymphatic, system, or cerebrospinal fluid, with the lung and pleura being the most common sites of extracranial metastases. A case of metastatic meningioma with high expression of CD90 was spotted during a review of flow cytometry data for lung malignancies. Therefore, we have analyzed CD90 expression in a series of meningioma metastases with their corresponding primary tumors and in a series of 92 primary meningioma tumors.


METHODS
In addition to flow cytometry and immunohistochemical analysis of the case, a series of meningiomas and relative metastases has been evaluated for CD90 immunohistochemical expression. Furthermore, an immunohistochemical analysis has been conducted in a tissue microarray, including typical and atypical meningiomas.


RESULTS
CD90 had high expression in three of four cases of metastases and in their corresponding primary atypical meningioma. In addition, CD90 was significantly expressed in atypical rather than in typical meningiomas (P = .003). However, the correlation of CD90 with patient survival reveals only a trend of statistical association with extracranial metastases.


CONCLUSIONS
CD90 is a biomarker overexpressed in atypical meningioma, with a potential role in metastatic switch of this tumor.
From the Pathology Department.
Giosuè
G
Scognamiglio
Pathology Unit, AO "San Giovanni Di Dio e Ruggi D'Aragona," Salerno, Italy;
Antonio
A
D'Antonio
Pathology Unit, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy;
Giulio
G
Rossi
Pathology Department, Santa Maria Nuova Hospital, Reggio Emilia, Italy;
Alberto
A
Cavazza
Experimental Oncology Unit.
Rosa
R
Camerlingo
Experimental Oncology Unit.
Giuseppe
G
Pirozzi
From the Pathology Department.
Elvira
E
La Mantia
From the Pathology Department.
Anna Maria
AM
Anniciello
Lung Medical Oncology Department, and.
Alessandro
A
Morabito
From the Pathology Department.
Monica
M
Cantile
Pathology Unit, AO "Antonio Cardarelli," Naples, Italy; and.
Amedeo
A
Boscaino
Pathology Unit, Ospedale Scarlato, Scafati, Salerno, Italy.
Lucianna
L
Sparano
From the Pathology Department.
Gerardo
G
Botti
Department of Thoracic Surgery and Oncology, "ISTITUTO NAZIONALE TUMORI Fondazione G. PASCALE," IRCCS, Naples, Italy;
Gaetano
G
Rocco
From the Pathology Department, r.franco@istitutotumori.na.it.
Renato
R
Franco
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000378:metabolism; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D018800:Thy-1 Antigens / Q000378:metabolism*; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018800:Thy-1 Antigens
CD90; Flow cytometry; Immunohistochemistry; Meningioma