Are matrix effects the Achilles heel in the bioanalysis of biotherapeutics by ligand-binding assays?
Proteomics Core Laboratory, Centers for Cancer Pharmacology & Excellence in Environmental Toxicology, Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Qingqing
Q
Wang
Mark
M
Ma
D001681:Biological Assay / Q000379:methods*; D001688:Biological Products / Q000032:analysis*; D006801:Humans; D008024:Ligands
D001688:Biological Products; D008024:Ligands
biotherapeutics; ligand-binding assay; matrix effects; nonspecific interference