Methods of identification of pseudogenes based on functionality: hybridization of 18S rRNA and mRNA during translation.
Protein-coding sequences are characterized by a period-3 free energy signal that arises from the interaction between the 3'-terminal nucleotides of the 18S rRNA and the mRNA. Such a signal is not present in noncoding sequences such as introns and intergenic regions and can be used for pseudogene identification.
Department of Biostatistics, Boston University, School of Public Health, Boston, MA, USA, chuanhua.xing@gmail.com.
Chuanhua
C
Xing
D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D023281:Genomics / Q000379:methods*; D006801:Humans; D009690:Nucleic Acid Conformation; D011544:Pseudogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012337:RNA, Ribosomal, 18S / Q000235:genetics / Q000378:metabolism; D064878:Web Browser
D012333:RNA, Messenger; D012337:RNA, Ribosomal, 18S