Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes.
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In this study, we examined the effects of xanthohumol-rich hop extract containing 17.8% xanthohumol and 12.4% isoxanthohumol on the differentiation and adipogenesis of 3T3L1 cells. We observed that the extract inhibited the differentiation of 3T3L1 cells and intracellular fat droplets via the regulation of adipogenic factors such as the peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein alpha, and adipocyte fatty acid-binding protein.
Department of Agricultural Chemistry, School of Agriculture, Meiji University.
Ayane
A
Kiyofuji
Kazuki
K
Yui
Koki
K
Takahashi
Kyoichi
K
Osada
D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000818:Animals; D019440:Anti-Obesity Agents; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D027582:Humulus / Q000737:chemistry*; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011427:Propiophenones / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology
D019440:Anti-Obesity Agents; D022763:CCAAT-Enhancer-Binding Protein-alpha; C493411:Fabp4 protein, mouse; D050556:Fatty Acid-Binding Proteins; D005419:Flavonoids; D047495:PPAR gamma; D010936:Plant Extracts; D011427:Propiophenones; D044004:Xanthones; C512910:isoxanthohumol; C104536:xanthohumol