Impact of isolated hepatitis C virus (HCV) core-specific antibody detection and viral RNA amplification among HCV-seronegative dialysis patients at risk for infection.
Amplification of hepatitis C virus (HCV) RNA from blood detected occult HCV infections in 30.9% of 210 HCV-seronegative dialysis patients with abnormal liver enzyme levels that had evaded standard HCV testing practices. Isolated HCV core-specific antibody detection identified three additional anti-HCV screening-negative patients lacking HCV RNA amplification in blood who were considered potentially infectious. Together, these findings may affect management of the dialysis setting.
Nephrology, Hospital Universitario de La Princesa, Madrid, Spain.
Guillermina
G
Barril
Fundación Estudio Hepatitis Virales, Madrid, Spain.
Juan A
JA
Quiroga
Nephrology, Hospital Perpetuo Socorro, Alicante, Spain.
María Dolores
MD
Arenas
Nephrology, Hospital Reina Sofía, Cordoba, Spain.
Mario
M
Espinosa
Nephrology, Clínica Universitaria de Navarra, Pamplona, Spain.
Nuria
N
García-Fernández
Nephrology, Hospital da Costa, Burela, Lugo, Spain.
Secundino
S
Cigarrán
Nephrology, Hospital Clínico San Carlos, Madrid, Spain.
José A
JA
Herrero
Nephrology, Hospital La Paz, Madrid, Spain.
Gloria
G
del Peso
Nephrology, Clínica Rúber, Madrid, Spain.
Pilar
P
Caro
Complejo Hospitalario La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain.
Rebeca
R
García-Agudo
Clínica Fuensanta, Madrid, Spain.
Yésica
Y
Amézquita
Dial Centro, Madrid, Spain.
Ana
A
Blanco
ICN El Pilar, Madrid, Spain.
Pilar
P
Martínez-Rubio
Nephrology, Hospital 12 de Octubre, Madrid, Spain.
José M
JM
Alcázar
Nephrology, Hospital Central de la Defensa, Madrid, Spain.
Emilio
E
González-Parra
Nephrology, Hospital de Poniente, Almería, Spain.
Adoración
A
Martín-Gómez
Fundación Estudio Hepatitis Virales, Madrid, Spain.
Inmaculada
I
Castillo
Fundación Estudio Hepatitis Virales, Madrid, Spain.
Javier
J
Bartolomé
Fundación Estudio Hepatitis Virales, Madrid, Spain fehvhpa@fehv.org.
Vicente
V
Carreño
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004798:Enzymes / Q000097:blood; D005260:Female; D006526:Hepatitis C / Q000175:diagnosis* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000276:immunology*; D012367:RNA, Viral / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects*; D014758:Viral Core Proteins / Q000276:immunology*
D004798:Enzymes; D018937:Hepatitis C Antibodies; D010446:Peptide Fragments; D012367:RNA, Viral; D014758:Viral Core Proteins; C511446:core protein (1-120), hepatitis C virus