The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms.
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, Brasil.
Policarpo Ademar
PA
Sales Júnior
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora,, MG, Brasil.
Celso Oliveira
CO
Rezende Júnior
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora,, MG, Brasil.
Mireille
M
Le Hyaric
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora,, MG, Brasil.
Mauro Vieira de
MV
Almeida
Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, Brasil.
Alvaro José
AJ
Romanha
D000605:Amino Alcohols / Q000494:pharmacology*; D003959:Diamines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D021261:Parasitic Sensitivity Tests; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000605:Amino Alcohols; D003959:Diamines; D014344:Trypanocidal Agents