Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort.
OBJECTIVE
To investigate interactions on gestational age among two environmental risk factors and four maternal genetic polymorphisms: organic solvents, passive smoking, CYP1A1 rs4646903 (MspI), EPHX1 rs2234922 (His139Arg), GSTT1 and PON2 rs12026 (Ala148Gly).


METHODS
A pregnant women cohort was conducted at Beijing Yanshan Petrochemical Corporation, and 1,097 mothers with live singleton births were included in analysis. Generalized Multifactor Dimensionality Reduction (GMDR) method was used to explore interactions among these factors with adjustment for important potential confounders. Multiple linear regression models were used to estimate the association of interaction with gestational age.


RESULTS
A three-factor model of organic solvents, GSTT1 and PON2 rs12026 had the highest testing balanced accuracy (57.05 %) and best cross-validation consistency (10/10). Compared with organic solvents unexposed mothers with GSTT1 non-null genotype and PON2 rs12026 CC genotype, organic solvents exposed mothers with GSTT1 null genotype and PON2 rs12026 CG + GG genotype had the largest reduction in gestational age (-0.36 weeks, 95%CI: -0.70 to -0.02). The significant reductions in different groups were from 0.24 weeks to 0.36 weeks.


CONCLUSIONS
Maternal genetic susceptibility GSTT1 and PON2 rs12026 could significantly modify the association of organic solvents with gestational age.
Department of Biostatistics and Epidemiology, School of Public Health, Peking University, No.38, Xueyuan Road, Beijing, China.
Shuai
S
Li
Kai
K
Fang
Wenjian
W
Wang
Yonghua
Y
Hu
Dafang
D
Chen
D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D005838:Genotype; D005865:Gestational Age; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012307:Risk Factors; D012997:Solvents / Q000633:toxicity
D012997:Solvents; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase; D043303:Aryldialkylphosphatase; C468411:PON2 protein, human