Off-line consolidation of motor sequence learning results in greater integration within a cortico-striatal functional network.
The consolidation of motor sequence learning is known to depend on sleep. Work in our laboratory and others have shown that the striatum is associated with this off-line consolidation process. In this study, we aimed to quantify the sleep-dependent dynamic changes occurring at the network level using a measure of functional integration. We directly compared changes in connectivity before and after sleep or the simple passage of daytime. As predicted, the results revealed greater integration within the cortico-striatal network after sleep, but not an equivalent daytime period. Importantly, a similar pattern of results was also observed using a data-driven approach; the increase in integration being specific to a cortico-striatal network, but not to other known functional networks. These findings reveal, for the first time, a new signature of motor sequence consolidation: a greater between-regions interaction within the cortico-striatal system.
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Department of Psychology, University of Montreal, Québec, Canada.
Karen
K
Debas
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Cœur de Montréal, Québec, Canada; Department of Psychology, University of Montreal, Québec, Canada.
Julie
J
Carrier
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Department of Psychology, University of Montreal, Québec, Canada.
Marc
M
Barakat
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Unité Mixte de Recherche-S 678, INSERM/University, Paris VI, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France.
Guillaume
G
Marrelec
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada.
Pierre
P
Bellec
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada.
Abdallah
A
Hadj Tahar
Laboratory for Functional Brain Imaging and Learning Research, The Brain-Behavior Center, University of Haifa, Haifa, Israel.
Avi
A
Karni
Laboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA.
Leslie G
LG
Ungerleider
Unité Mixte de Recherche-S 678, INSERM/University, Paris VI, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France.
Habib
H
Benali
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Department of Psychology, University of Montreal, Québec, Canada; Unité Mixte de Recherche-S 678, INSERM/University, Paris VI, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France. Electronic address: julien.doyon@umontreal.ca.
Julien
J
Doyon
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D017072:Neostriatum / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D011214:Practice, Psychological; D012890:Sleep / Q000502:physiology; D055815:Young Adult
Consolidation; Functional connectivity; Motor learning; Networks; Sleep; fMRI