Fibrogenesis in granulomas and lung interstitium in tuberculous inflammation in mice.
The study in mouse model of BCG-induced granulomatous inflammation showed that early pulmonary fibrosis (day 3-30 postinfection) in tuberculous inflammation was primarily determined by increased number of fibroblasts in the lung interstitium and granulomas and enhanced fibroplastic activity. Fibroplastic processes are initiated via an increase in secretory activity of activated granuloma macrophages caused by the persistence of the pathogen in the cells of the mononuclear phagocytic system. The dynamics of hydroxyproline concentration under these conditions is determined by changes in the number and differentiation degree of fibroblasts in granulomas and lung interstitium at various stages of tuberculous inflammation.
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
V A
VA
Shkurupiy
L B
LB
Kim
O V
OV
Potapova
L A
LA
Cherdantseva
A N
AN
Putyatina
I K
IK
Nikonova
D000818:Animals; D001500:BCG Vaccine / Q000009:adverse effects*; D049109:Cell Proliferation; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000378:metabolism; D006099:Granuloma / Q000473:pathology*; D006909:Hydroxyproline / Q000378:metabolism; D007249:Inflammation / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000472:pathogenicity; D011658:Pulmonary Fibrosis / Q000382:microbiology / Q000473:pathology*; D014397:Tuberculosis, Pulmonary / Q000382:microbiology / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D001500:BCG Vaccine; D014409:Tumor Necrosis Factor-alpha; D006909:Hydroxyproline