Bioactive tyrosine-derived cytochalasins from fungus Eutypella sp. D-1.
Three new cytochalasins Z24 , Z25 , Z26 (1-3, resp.) and one known compound, scoparasin B (4), were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of the Arctic. The structures of 1-3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF-7 cell line with IC50 of 9.33 μM.
College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, P. R.China, (phone: +86-21-81870970-8004 (X.-L. L.), +86-21-81870972 (X.-Y. L.); fax: +86-21-65334344).
Jing-Tang
JT
Liu
Bo
B
Hu
Yun
Y
Gao
Jian-Peng
JP
Zhang
Bing-Hua
BH
Jiao
Xiao-Ling
XL
Lu
Xiao-Yu
XY
Liu
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003572:Cytochalasins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D061986:MCF-7 Cells; D009369:Neoplasms / Q000188:drug therapy; D014443:Tyrosine / Q000737:chemistry; D013098:Xylariales / Q000737:chemistry*
D000970:Antineoplastic Agents; D003572:Cytochalasins; D014443:Tyrosine
Arctic fungi; Cytochalasins; Cytotoxic activity; Eutypella; Fungi