Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
We previously found that genetic polymorphisms in gene coding for histamine H4 receptors were related to the risk and malignant degree of breast cancer. The roles of polymorphisms in other histamine-related genes, such as histidine decarboxylase (HDC), histamine N-methyltransferase (HNMT) and histamine H3 receptor (HRH3), remain unexplored. The aim of this study is to analyze the clinical associations of polymorphisms in HDC, HNMT and HRH3 with breast cancer. Two hundred and one unrelated Chinese Han breast cancer patients and 205 ethnicity-matched health controls were recruited for case-control investigation. Genomic DNA from the participants was extracted and 5 single nucleotide polymorphisms (SNPs) in HDC, HNMT and HRH3 were genotyped. We found that polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. However, the T allele of rs7164386 in HDC significantly decreased the risk of breast cancer (adjusted odds ratios [ORs], 0.387; 95% confidence intervals [CIs], 0.208-0.720; P = 0.003). Furthermore, for HDC haplotypes, the CG haplotype of rs7164386-rs7182203 was more frequent among breast cancer patients (adjusted OR, 1.828; 95% CI, 1.218-2.744; P = 0.004) while the TG haplotype was more frequent among health controls (adjusted OR, 0.351; 95% CI, 0.182-0.678; P = 0.002). These findings indicated that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. Further studies with larger participants worldwide are still needed for conclusion validation.
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China.
Gong-Hao
GH
He
Department of neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Jia-Ji
JJ
Lin
Department of Cardio-Thoracic Surgery, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China.
Wen-Ke
WK
Cai
Department of Pathology, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China.
Wen-Mang
WM
Xu
Department of Labour Hygiene, College of Military Preventive Medicine, Third Military Medical University, Chongqing, China.
Zheng-Ping
ZP
Yu
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China.
Sun-Jun
SJ
Yin
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China.
Can-Hu
CH
Zhao
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China.
Gui-Li
GL
Xu
D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000503:physiopathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000503:physiopathology; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006640:Histidine Decarboxylase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018100:Receptors, Histamine H3 / Q000235:genetics*
D018100:Receptors, Histamine H3; D006637:Histamine N-Methyltransferase; D006640:Histidine Decarboxylase