Evaluation of Cardiac Markers in Children Undergoing Hematopoietic Stem Cell Transplantation.
BACKGROUND
Early life-threatening cardiotoxicity and cardiac death have been reported after hematopoietic stem cell transplantation (HSCT). The purpose of the current study was to evaluate cardiac toxicity of conventional chemotherapy followed by HSCT with cardiac markers: heart-type fatty acid binding protein (H-FABP), glycogen phosphorylase BB (GPBB), high sensitive C reactive protein (hsCRP) cardiac troponin I, (cTnI), creatine kinase MB (CK-MB mass) and myoglobin.


METHODS
A total of 20 children who underwent HSCT for malignant and non-malignant diseases were included in this study. Blood samples were collected from all patients in 0th, 7th and 21st day for evaluating these cardiac biomarkers. The patients' echocardiography was assessment before and after one-month of HSCT.


RESULTS
Serum 21st H-FABP level was significantly higher when compared with the 0th day H-FABP level (P < 0.05) . 7th day hsCRP level was significantly higher than 0th and 21st day levels (P < 0.05). Interestingly, 7th day GPBB level was significantly lower than 0th and 21st day levels (P < 0.05). Myoglobin, CK-MB mass and cTnI biomarkers remained within the reference range in all patients.


CONCLUSIONS
This study showed that H-FABP and hsCRP both seem to be promising markers for evaluation of cardiotoxicity in HSCT process and probably superior to GPBB, cTnI, CK-MB mass and myoglobin.
Department of Biochemistry Diskapi Yildirim Beyazit Education and Research Hospital.
Gulfer
G
Ozturk
Department of Pediatric Hematology, Faculty of Medicine, Hacettepe University.
Betul
B
Tavil
Stem Cell Research Laboratory, Ankara Children's Hematology and Oncology Hospital.
Meltem
M
Ozguner
Department of Biochemistry Diskapi Yildirim Beyazit Education and Research Hospital.
Zeynep
Z
Ginis
Department of Biochemistry Diskapi Yildirim Beyazit Education and Research Hospital.
Gonul
G
Erden
Department of Pediatric Hematology Oncology, Ankara Children's Hematology and Oncology Hospital.
Bahattin
B
Tunc
Department of Pediatric Hematology Oncology, Ankara Children's Hematology and Oncology Hospital.
M Fatih
MF
Azik
Department of Pediatric Hematology, Faculty of Medicine, Hacettepe University.
Duygu
D
Uckan
Department of Biochemistry Diskapi Yildirim Beyazit Education and Research Hospital.
Namik
N
Delibas
D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D055815:Young Adult
D015415:Biomarkers
H-FABP; chemotherapy; children; glycogen phosphorylase BB; hsCRP