Treatment outcomes of female germ cell tumors: the Egyptian National Cancer Institute experience.
BACKGROUND
Female germ cell tumors (GCTS) are rare tumors that carry a good prognosis.


OBJECTIVE
To report the experience of the Egyptian National Cancer Institute (ENCI) in managing female GCTs.


METHODS
This retrospective study included 19 females with ovarian GCTs presenting to the ENCI between 2006 and 2010.


RESULTS
The median age was 23years. Ovaries were the primary site in all patients. Dysgerminoma and teratoma were the predominant pathologies followed by mixed GCT in females. Unilateral ovariectomy or ovarian tumorectomy were the classic surgical procedures with R0 resection being feasible in most cases. Surveillance was adopted in six patients with stage I disease. Chemotherapy was administered in 63% of ovarian GCTs with BEP being the commonest regimen with reasonable tolerability and good response rates. The median OS and EFS were not reached. The projected 5-year OS rate was 93.8%. Both OS and EFS were better in patients responding to chemotherapy than non-responders (p<0.002). Stage of disease did not significantly affect OS or EFS.


CONCLUSIONS
Female GCTs rarely affect Egyptian females. They have good prognosis.
Medical Oncology Department, NCI, Cairo University, Egypt.
Magdy M
MM
Saber
Medical Oncology Department, NCI, Cairo University, Egypt.
Ahmed A
AA
Zeeneldin
Medical Oncology Department, NCI, Cairo University, Egypt. Electronic address: elgammalmosaad@yahoo.com.
Mosaad M
MM
El Gammal
Medical Oncology Department, NCI, Cairo University, Egypt.
Salem E
SE
Salem
Medical Oncology Department, NCI, Cairo University, Egypt.
Amira D
AD
Darweesh
Medical Oncology Department, NCI, Cairo University, Egypt.
Alshaymaa A
AA
Abdelaziz
Department of Medical Statics, NCI, Cairo University, Egypt.
Manar
M
Monir
D000293:Adolescent; D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
D005047:Etoposide; D002945:Cisplatin
Chemotherapy; Female germ-cell tumors; Side effects; Survival; Treatment