Role of liquid membrane phenomenon in the anti-bacterial activity of Cefuroxime Sodium.
The role of liquid membrane phenomenon has been studied in the anti bacterial activity of cephalosporins i.e. Cefuroxime sodium. In our earlier publication [1] it was reported that hydraulic permeability data obtained to demonstrate the existence of liquid membrane in series with supporting membrane generated by Cefuroxime sodium. Transport of selected permeants (glucose, PABA, glycine, and ions like Mg(++), NH4 (+), PO4 (-), Ca(++), Na(+), K(+) and Cl(-)) through liquid membrane generated by Cefuroxime sodium in series with supporting membrane has been studied. The results indicated that the liquid membrane generated by Cefuroxime sodium inhibit the transport of various essential bio-molecules and permeants in to the cell. This modification in permeability of different permeants in the presence of the liquid membranes is likely to play significant role in the biological actions of Cefuroxime sodium. The anti-bacterial activity of Cefuroxime sodium further confirmed that the generation of liquid membrane by Cefuroxime sodium is also contributing for the antibacterial activity of them.
Galen Laboratory, Salipur, S. C. S. College of Pharmacy, Harapanahalli - 583131, Karnataka, India.
C
C
Nagesh
Galen Laboratory, Salipur, S. C. S. College of Pharmacy, Harapanahalli - 583131, Karnataka, India.
M M
MM
Shankaraiah
Galen Laboratory, Salipur, S. C. S. College of Pharmacy, Harapanahalli - 583131, Karnataka, India.
J S
JS
Venkatesh
College of Clinical Pharmacy, King Faisal University, AL AHSA, 31982, KSA.
S Ramachandra
SR
Setty
Cefuroxime sodium; anti-microbial activity; hydraulic permeability; liquid membrane; solute permeability