[Mass spectrometry of blood low-molecular fraction as a method for unification of therapeutic drug monitoring].
The article describes a new therapeutic drug monitoring (TDM) method based on direct infusion of low-molecular fraction of blood into electrospray ionization source of mass spectrometer. This technique allows performing TDM of almost all drugs used in clinic. In article, the universality and high-throughput of the method, that significantly simplifies its wide application, have been shown. Moreover, the possibility of method application in most cases of drug therapy has been argued as a tool of control of drug doses, rationality of drug therapy, and the quality of the drugs themselves. In conclusion, the prospects for application of the method as primary means of improving the quality and personalization of drug therapy have been discussed.
P G
PG
Lokhov
D L
DL
Maslov
O P
OP
Trifonova
E E
EE
Balashova
A I
AI
Archakov
D001774:Blood Chemical Analysis / Q000379:methods*; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000097:blood*; D057285:Precision Medicine; D012680:Sensitivity and Specificity
D004364:Pharmaceutical Preparations
capillary blood; direct mass spectrometry; mass spectrometry; personalize drug therapy; therapeutic drug monitoring (TDM)