Systemic sclerosis biomarkers discovered using mass-spectrometry-based proteomics: a systematic review.
BACKGROUND
Systemic sclerosis (SSc) is an autoimmune disease with incompletely known physiopathology. There is a great challenge to predict its course and therapeutic response using biomarkers.


OBJECTIVE
To critically review proteomic biomarkers discovered from biological specimens from systemic sclerosis patients using mass spectrometry technologies.


METHODS
Medline and Embase databases were searched in February 2014.


RESULTS
Out of the 199 records retrieved, a total of 20 records were included, identifying 116 candidate proteomic biomarkers.


CONCLUSIONS
Research in SSc proteomic biomarkers should focus on biomarker validation, as there are valuable mass-spectrometry proteomics studies in the literature.
Clinical Immunology Department, Colentina Clinical Hospital , Bucharest , Romania .
Paul
P
Bălănescu
Anca
A
Lădaru
Eugenia
E
Bălănescu
Cristian
C
Băicuş
Gheorghe Andrei
GA
Dan
D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000378:metabolism*; D012680:Sensitivity and Specificity
D015415:Biomarkers; D020543:Proteome
Autoimmunity; biomarker validation; proteomic biomarkers; proteomics; systemic sclerosis