Pertussis seroprevalence in korean adolescents and adults using anti-pertussis toxin immunoglobulin G.
This study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy adolescents and adults 11 yr of age or older were collected between July 2012 and December 2012, and anti-pertussis toxin (PT) IgG titers were measured using a commercial ELISA kit. We compared the mean anti-PT IgG titers and seroprevalence of pertussis of the six age groups: 11-20, 21-30, 31-40, 41-50, 51-60, and ≥ 61 yr. A total of 1,192 subjects were enrolled. The mean anti-PT IgG titer and pertussis seroprevalence were 35.53 ± 62.91 EU/mL and 41.4%, respectively. The mean anti-PT IgG titers and seroprevalence were not significantly different between the age groups. However, the seroprevalence in individuals 51 yr of age or older was significantly higher than in individuals younger than 51 yr (46.5% vs 39.1%, P = 0.017). Based on these results, a new pertussis prevention strategy is necessary for older adults.
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Soo Young
0000-0002-5354-3135
SY
Lee
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seung Beom
0000-0002-1299-2137
SB
Han
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
E Young
0000-0003-2777-210X
EY
Bae
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jong-Hyun
0000-0001-8641-7904
JH
Kim
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jin Han
0000-0003-1610-6742
JH
Kang
Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yeon-Joon
0000-0003-2182-5821
YJ
Park
Department of Pediatrics, Changwon Fatima Hospital, Changwon, Korea.
Sang Hyuk
0000-0002-0582-9286
SH
Ma
D000293:Adolescent; D000328:Adult; D000375:Aging; D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D037342:Pertussis Toxin / Q000097:blood / Q000276:immunology*; D010567:Pertussis Vaccine / Q000276:immunology; D056910:Republic of Korea / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D014611:Vaccination; D014917:Whooping Cough / Q000097:blood / Q000453:epidemiology*; D055815:Young Adult
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D037342:Pertussis Toxin
Korea; Pertussis Vaccine; Prevalence; Vaccination