Antenatal predictors and body composition of large-for-gestational-age newborns: perinatal health outcomes.
OBJECTIVE
To compare body composition of large-for-gestational-age (LGA) with appropriate-for-gestational-age (AGA) newborns and to identify antenatal predictors of LGA.


METHODS
This cross-sectional study included 536 term, singleton infants. Anthropometric measurements were performed within 48 h of birth and included determination of body fat percentage (%BF) by air displacement plethysmography. Associations were investigated using logistic regression.


RESULTS
LGA infants had greater %BF (P<0.001) compared with AGA infants. Significant predictors of LGA infants included parity (odds ratio (OR)=1.98, (95% confidence interval (CI) 1.00, 4.02)), paternal height (OR=1.08, (95% CI 1.03, 1.14)), maternal pregravid weight (65 to 74.9 kg: OR=2.77, (95% CI 1.14, 7.06)) and gestational weight gain (OR=1.09, 95% CI (1.03, 1.16)). Gestational diabetes mellitus was not associated with LGA infants (P=0.598).


CONCLUSIONS
Paternal height, parity, maternal pregravid weight and gestational weight gain were strongly associated with LGA infants. These results may allow early prediction and potential modification, thereby optimising clinical outcomes.
Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
E L
EL
Donnelley
Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
C H
CH
Raynes-Greenow
Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
R M
RM
Turner
Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
A E
AE
Carberry
1] Sydney Medical School, University of Sydney, Sydney, NSW, Australia [2] Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia [3] RPA Newborn Care, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
H E
HE
Jeffery
D000328:Adult; D000886:Anthropometry; D001823:Body Composition; D001827:Body Height; D001835:Body Weight; D003430:Cross-Sectional Studies; D005220:Fathers; D005260:Female; D005544:Forecasting; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007233:Infant, Postmature; D008297:Male; D009035:Mothers; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome