KSRP controls pleiotropic cellular functions.
The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.
Gene Expression Regulation Laboratory, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, 16132 Genova, Italy. Electronic address: rgherzi@ucsd.edu.
Roberto
R
Gherzi
Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Ching-Yi
CY
Chen
Molecular Structure Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
Andres
A
Ramos
Gene Expression Regulation Laboratory, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, 16132 Genova, Italy. Electronic address: paola.briata@hsanmartino.it.
Paola
P
Briata
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D005802:Genes, MHC Class II; D006801:Humans; D050356:Lipid Metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*
D016207:Cytokines; C105789:KHSRP protein, human; D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators
Cell differentiation; Immune response; KH domain; Lipid metabolism; mRNA decay; microRNA maturation