Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair.
Transvaginal repair with mesh of pelvic organ prolapse (POP) provides women with the durability of a synthetic graft using the less-invasive route of vaginal surgery. However, morbidities such as mesh exposures are common and challenging to manage. Small intestinal submucosa (SIS) is a naturally occurring collagen matrix derived from porcine intestine. It contains growth factors and cytokines that promote healing of damaged tissue. This case report describes a large vaginal mesh exposure due to necrosis of the full thickness of the anterior vaginal wall. A remarkable and rapid regeneration of vaginal tissue over the exposed mesh was achieved with SIS placement after failure of treatment with vaginal estrogen for >6 months. Collagen scaffold is an effective, rapid, and minimally invasive treatment for large vaginal mesh exposures.
Department of Reproductive Medicine, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0863, USA, malperin@ucsd.edu.
Marianna
M
Alperin
D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy*; D013526:Surgical Mesh / Q000009:adverse effects*; D054457:Tissue Scaffolds
C588278:surgisis; D003094:Collagen