Pharmacological stimulation of the regenerative capacity of rat testes damaged by paclitaxel.
Productivity of spermatogenesis and the population of spermatogonial cells were substantially reduced in male Wistar rats 3 months after administration of cytostatic drug paclitaxel, damaging stem spermatogonia. However, signs of reparative regeneration appeared in the testicular tissue. In animals receiving paclitaxel in combination with granulocyte CSF, the same period of observation, the number of spermatogonia and the efficiency of spermatogenesis at the same terms of the study did not differ from those in intact animals. Intensive recovery processes started 1 month earlier than after administration of paclitaxel alone. These data attest to pronounced potentiating effect of granulocyte CSF on reparative regeneration of the testicular tissue.
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, repropharm@yandex.ru.
T G
TG
Borovskaya
A M
AM
Dygai
Y A
YA
Shchemerova
A V
AV
Vychuzhanina
M E
ME
Poluektova
V E
VE
Goldberg
D N
DN
Kinsht
K I
KI
Ershov
P G
PG
Madonov
D000818:Animals; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D008297:Male; D017239:Paclitaxel / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects*; D013093:Spermatogonia / Q000378:metabolism; D013737:Testis / Q000473:pathology*
D016179:Granulocyte Colony-Stimulating Factor; D017239:Paclitaxel