Endogenous regulation of inflammatory pain by T-cell-derived opioids: when friend turns to foe.
Painful sensation is a hallmark of microbe-induced inflammation. This inflammatory pain is downregulated a few days after infection by opioids locally released by effector T lymphocytes generated in response to microbe-derived antigens. This review focuses on the endogenous regulation of inflammatory pain associated with adaptive T-cell response and puts in perspective the clinical consequences of the opioid-mediated analgesic activity of colitogenic T lymphocytes in inflammatory bowel disease.
*INSERM, Unit 1043, Toulouse, France; †CNRS, Unit 5282, Toulouse, France; ‡Centre de Physiopathologie de Toulouse Purpan, Université de Toulouse, UPS, Toulouse, France; §INSERM, Unit 913, Nantes, France; and ‖Institut des Maladies de l'Appareil Digestif, Université de Nantes, Nantes, France.
Lilian
L
Basso
Jérôme
J
Boué
Arnaud
A
Bourreille
Gilles
G
Dietrich
D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology; D018847:Opioid Peptides / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D018847:Opioid Peptides