Characteristics of early- and late-onset rapid eye movement sleep behavior disorder in China: a case-control study.
OBJECTIVE
To investigate demography and clinic and polysomnographic characteristics in Chinese rapid eye movement (REM) sleep behavior disorder (RBD) patients across onset ages.


METHODS
Ninety consecutive patients fulfilling the criteria for RBD were recruited for study in our sleep center. Patients were separated into early- and late-onset groups according to age when symptoms began (< or =50 and >50 years, respectively). Ninety age- and gender-matched healthy subjects served as controls. All subjects were interviewed for their clinical history, completed an RBD questionnaire, and underwent an overnight video polysomnography assessment. Demographics, comorbidities, scores on the RBD questionnaire, sleep architecture, and EMG activity were compared between the patients and controls and between the early- and late-onset groups.


RESULTS
Of all RBD patients, 63 were male, and mean age of RBD onset was 54.3±15.7 years. In 25 patients (28%), RBD was secondary and associated with neurodegenerative disease, narcolepsy or antidepressant use. Twenty-three patients (26%) had early-onset RBD and 67 (74%) were in the late-onset group. RBD patients had significantly more comorbidities, dreams and dream-enacting behaviors, and poorer sleep quality than did controls. The early-onset group had a high proportion of females (48%) and an increased proportion of cases associated with narcolepsy. The early-onset group also had fewer movements, lower EMG activity during REM sleep, and better sleep quality when compared to the late-onset group. EMG activity was positively correlated with age of onset. The mean follow-up time was 1.57±0.82 years, and four patients in the late-onset group were subsequently diagnosed with neurodegenerative diseases.


CONCLUSIONS
Stratifying patients into early and late-onset RBD revealed different characteristics from those previously described as typical for RBD. EMG activity during REM sleep was positively correlated with age of onset. We suggest that it will be valuable to explore the relationship between age of onset conversion and neurodegenerative diseases.
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China; Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Junying
J
Zhou
Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
Jihui
J
Zhang
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Lina
L
Du
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Zhe
Z
Li
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Yun
Y
Li
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Fei
F
Lei
Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
Yun-Kwok
YK
Wing
Sleep Medicine Center, Stanford University, CA, USA.
Clete A
CA
Kushida
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Dong
D
Zhou
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address: xiangdong.tang@gmail.com.
Xiangdong
X
Tang
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004325:Dreams / Q000502:physiology; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
Age at onset; China; Narcolepsy; Neurodegenerative; Polysomnography; REM sleep behavior disorder