Healing efficacy of methanol extract of leaves of Alternanthera brasiliana Kuntze in aged wound model.
The methanol extract of Alternanthera brasiliana Kuntze (Family: Amaranthaceae) leaf was investigated for its wound healing effect by excision wound model (in vivo) in aged Sprague Dawley rats. In excision wound model, compared to the control group, percent contraction of wound was significantly (P < 0.01) higher in A. brasiliana-treated group (5% w/w ointment). The collagen, elastin, and hydroxyproline contents of the granulation tissue of A. brasiliana-treated group increased significantly (P < 0.01) compared to the control group, indicating better wound healing activity of the test plant. These findings were also confirmed by histopathological examination. The results suggested that methanol extract of A. brasiliana possesses significant wound healing potential in aged animal wound model.
Department of Pharmacology and Toxicology, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
Chandana Choudhury
CC
Barua
Department of Pharmacology and Toxicology, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
Shameem Ara
SA
Begum
Department of Veterinary Microbiology, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
Dilip Kumar
DK
Sarma
Department of Veterinary Pathology, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
Debesh Chandra
DC
Pathak
Livestock Production and Management, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
Rumi Saikia
RS
Borah
Alternanthera brasiliana; excision wound; incision wound; wound healing