Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs.
The Toxoplasma gondii virulence factors ROP5 and ROP18 both target immunity-related GTPases (IRGs) to evade immunity. In this issue of Cell Host & Microbe, Etheridge et al. (2014) identify a third virulence factor, ROP17, which forms a complex and synergizes with ROP5/ROP18 to fully disable the IRG system of antiparasite defense.
Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07101, USA.
Yanlin
Y
Zhao
Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07101, USA. Electronic address: yapgs@njms.rutgers.edu.
George S
GS
Yap
D000818:Animals; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism*; D014122:Toxoplasma / Q000201:enzymology* / Q000472:pathogenicity*; D014123:Toxoplasmosis / Q000469:parasitology*
D015800:Protozoan Proteins; D017346:Protein Serine-Threonine Kinases