A matched cohort study comparing the outcome of intrauterine adhesiolysis for Asherman's syndrome after uterine artery embolization or surgical trauma.
OBJECTIVE
To compare the outcome of hysteroscopic adhesiolysis in women who had Asherman's syndrome after uterine artery embolization (UAE) with those who had Asherman's syndrome caused by surgical trauma.


METHODS
A retrospective cohort study matched for age and intrauterine adhesion score (Canadian Task Force classification II-2).


METHODS
A tertiary hysteroscopic center in a teaching hospital.


METHODS
Nineteen women with Asherman's syndrome after UAE and 57 women with Asherman's syndrome caused by surgical trauma.


METHODS
Hysteroscopic adhesiolysis was followed by a second-look hysteroscopy 1 month later. The scoring system proposed by the American Fertility Society was used to evaluate intrauterine adhesion during hysteroscopy.


RESULTS
In the UAE group, only 42.1% of women experienced improvement in menstruation defined as a subjective increase in menstrual flow after surgery, which was significantly lower than that of 86.0% observed in the non-UAE group. In the UAE group, the reduction of the American Fertility Society (AFS) score after intrauterine adhesiolysis was 30%, which was significantly lower than that of 80% in the non-UAE group. The pregnancy rate and live birth rate in the UAE group (5% and 0%, respectively) were significantly lower than the corresponding rates in the non-UAE group (33% and 25%, respectively).


CONCLUSIONS
The outcome of hysteroscopic adhesiolysis in women with Asherman's syndrome after UAE was worse than in women with Asherman's syndrome caused by surgical trauma.
Department of Hysteroscopic Center, Fuxing Hospital, Capital Medical University, Beijing, China; Department of Reproductive Medicine and Surgery, Jessop Wing, Royal Hallamshire Hospital, University of Sheffield, UK.
Dongmei
D
Song
Department of Hysteroscopic Center, Fuxing Hospital, Capital Medical University, Beijing, China.
Yuhuan
Y
Liu
Department of Hysteroscopic Center, Fuxing Hospital, Capital Medical University, Beijing, China.
Yu
Y
Xiao
Department of Reproductive Medicine and Surgery, Jessop Wing, Royal Hallamshire Hospital, University of Sheffield, UK; Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Hong Kong, China.
Tin-Chiu
TC
Li
Department of Hysteroscopic Center, Fuxing Hospital, Capital Medical University, Beijing, China.
Fengqiong
F
Zhou
Department of Hysteroscopic Center, Fuxing Hospital, Capital Medical University, Beijing, China. Electronic address: xiaenlan2013@gmail.com.
Enlan
E
Xia
D000328:Adult; D016022:Case-Control Studies; D004210:Dissection; D005260:Female; D006175:Gynatresia / Q000209:etiology* / Q000601:surgery*; D006801:Humans; D015907:Hysteroscopy; D007049:Iatrogenic Disease; D008598:Menstruation / Q000502:physiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018873:Pregnancy Rate; D011379:Prognosis; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D055357:Uterine Artery Embolization / Q000009:adverse effects*; D014599:Uterus / Q000293:injuries*
Asherman's syndrome; Hysteroscopic adhesiolysis; Pregnancy outcome; Uterine artery embolization