CuAAC "click" active-template synthesis of functionalised [2]rotaxanes using small exo-substituted macrocycles: how small is too small?
Two "small" 22- and 24-membered exo-alcohol functionalised pyridyl macrocycles are exploited in the CuAAC active-template synthesis of [2]rotaxanes. The 24-membered macrocycle forms [2]rotaxanes in good yields while the smaller 22-membered macrocycle does not lead to interlocked products.
Department of Chemistry, University of Otago, PO Box 56, Dunedin, New Zealand. jcrowley@chemistry.otago.ac.nz.
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Noor
Warrick K C
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Stephen C
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Moratti
James D
JD
Crowley