Effects of the KIBRA Single Nucleotide Polymorphism on Synaptic Plasticity and Memory: A Review of the Literature.
There has been a great deal of interest recently in genetic effects on neurocognitive performance in the healthy population. KIBRA -a postsynaptic protein from the WWC family of proteins- was identified in 2003 in the human brain and kidney and has recently been associated with memory performance and synaptic plasticity. Through genome-wide screening, a single nucleotide polymorphism (SNP) was detected in the ninth intron of KIBRA gene (T→ C substitution) and was implicated in human memory and the underlying neuronal circuitry. This review presents a synopsis of the current findings on the effects of the KIBRA SNP on human memory and synaptic plasticity. Overall the findings suggest impaired memory performance and less efficient or impaired hippocampal/medial temporal lobe (MTL) activation in CC homozygotes (in comparison to T carriers) with some differences between young and older subjects. This review also highlights limitations and potential sources for variability of studies' imaging findings along with future perspectives and implications for the role of KIBRA in memory-related brain systems.
Clinical Unit Cambridge, GlaxoSmithKline, UK;
Laetitia C
LC
Schwab
Clinical Unit Cambridge, GlaxoSmithKline, UK;
Vincent
V
Luo
Clinical Unit Cambridge, GlaxoSmithKline, UK;
Chelsey L
CL
Clarke
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK; ; School of Psychology and Psychiatry, Monash University, Australia; ; Neuroscience Discovery Medicine, UCB Pharma, Belgium.
Pradeep J
PJ
Nathan
Cognition; KIBRA; episodic memory; fMRI; genetic polymorphism; synaptic plasticity.