Pulmonary hypertension in patients with advanced heart failure is associated with increased levels of interleukin-6.
BACKGROUND
Inflammatory, endothelial and neurohormonal biomarkers are involved in heart failure (HF) and pulmonary hypertension (PH) pathogenesis.


OBJECTIVE
To study these biomarkers in PH due to advanced HF.


METHODS
Thirty adults with HF were included. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), endothelin-1 and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured in peripheral vein and pulmonary artery during right heart catheterisation.


RESULTS
IL-6, TNF-α, hsCRP and NT-proBNP correlated with pulmonary pressures independent of ventricular function, HF etiology and vascular bed. IL-6 was independent predictor of systolic pulmonary artery pressure (sPAP).


CONCLUSIONS
Inflammatory biomarkers correlate to PH severity. IL-6 predicts sPAP in advanced HF.
Department of Cardiology, University Medical Centre Ljubljana , Ljubljana , Slovenia .
Jure
J
Dolenc
Miran
M
Šebeštjen
Bojan
B
Vrtovec
Mirta
M
Koželj
François
F
Haddad
D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D019332:Endothelin-1 / Q000032:analysis / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000032:analysis / Q000097:blood; D010446:Peptide Fragments / Q000032:analysis / Q000097:blood; D011651:Pulmonary Artery / Q000378:metabolism / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000097:blood
D015415:Biomarkers; D019332:Endothelin-1; D015850:Interleukin-6; D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
Biomarkers; echocardiography; inflammation; right heart catheterisation