The quest for the best metric of antibiotic use and its correlation with the emergence of fluoroquinolone resistance in children.
We evaluated the correlation between fluoroquinolone use, measured by doses administered and days of therapy, with the emergence of ciprofloxacin and levofloxacin resistance among Gram-negative bacilli infections in children hospitalized at one pediatric center between April 2001 and March 2009. Both metrics and drug resistance were highly correlated.
From the *Department of Pharmacy Practice, Western New England University College of Pharmacy, Springfield, Massachusetts; †Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; ‡Department of Pediatrics, Alfred I. duPont Hospital for Children, Wilmington, Delaware; §Nemours Biomedical Research, Wilmington, Delaware; ¶Department of Food and Resource Economics, University of Delaware, Newark, Delaware; and ‖Infectious Diseases Division, Department of Pediatrics, Vanderbilt University, Nashville, Tennessee.
Lucia
L
Rose
Marissa M
MM
Coulter
Shannon
S
Chan
Jobayer
J
Hossain
M Cecilia
MC
Di Pentima
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones