Paliperidone extended release for the treatment of pediatric and adolescent patients with Tourette's disorder.
OBJECTIVE
A subgroup of patients with Tourette's disorder (TD) has symptoms refractory to haloperidol, a standard therapeutic drug for TD.


METHODS
We report on three cases of pediatric and adolescent patients who were treated with paliperidone extended release.


RESULTS
In two cases, TD symptoms were remarkably improved by switching from haloperidol to paliperidone extended release, and in another case, paliperidone extended release showed significant efficacy in treating TD symptoms as the first-line drug. In all cases, no significant adverse side effects were detected.


CONCLUSIONS
Paliperidone extended release may be a strong candidate for the treatment of pediatric and adolescent patients with TD.
Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Kazuhiko
K
Yamamuro
Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Manabu
M
Makinodan
Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Toyosaku
T
Ota
Faculty of Nursing, Nara Medical University School of Medicine, Kashihara 634-8522, Japan.
Junzo
J
Iida
Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Toshifumi
T
Kishimoto
Haloperidol; Paliperidone extended release; Tics; Tourette's disorder