NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery.
Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Gerald
G
Barry
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Mariana
M
Varela
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Maxime
M
Ratinier
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, P.O. Box 7028, Uppsala SE-750 07, Sweden.|MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Anne-Lie
AL
Blomström
Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise 'G. Caporale', Teramo, Italy.|MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Marco
M
Caporale
Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany.
Frauke
F
Seehusen
Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany.
Kerstin
K
Hahn
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Esther
E
Schnettler
Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany.
Wolfgang
W
Baumgärtner
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Alain
A
Kohl
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Massimo
M
Palmarini
D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D016851:Orthobunyavirus / Q000276:immunology / Q000502:physiology*; D059748:Proteolysis; D012319:RNA Polymerase II / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000378:metabolism*
D017361:Viral Nonstructural Proteins; D012319:RNA Polymerase II