Analysis of risk factors for lipid intolerance of intravenous fat emulsion in very low birth weight infants.
In order to prevent fatty acid deficiency and to supply enough energy, intravenous fat emulsion is necessary for parenteral nutrition in preterm neonates. However, parenteral administration of intravenous fat emulsion can induce lipid intolerance. The purpose of this study was to analyze risk factors for lipid intolerance in very low birth weight infants. This retrospective study included 80 preterm neonates whose birth weight was less than 1,500 g. Subjects were divided into 2 categories: those with a serum triglyceride level of ≥ 200 mg/dl (n = 33, 41%) and those with a serum triglyceride level of < 200 mg/dl (n = 47, 59%). We conducted logistic regression analysis using variables which were significant in univariate analysis. All statistical analyses were processed in SPSS version 19.0. Four risk factors for lipid intolerance were obtained through analysis of the electronic medical record. Lipid intolerance occurred more frequently in neonates with sepsis; those with a birth weight less than 1,000 g; those who was administered intravenous fat emulsion more than 2.6 g/kg/day; and those whose gestational age was less than 28 weeks. It is suggested that serum triglyceride levels should be closely monitored to prevent lipid intolerance in preterm neonates with the aforementioned characteristics.
Department of Pharmacy, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, Korea.
Yoo-jung
YJ
Choi
Hye-jung
HJ
Bae
Ju-young
JY
Lee
Eun-jung
EJ
Cho
Yong-hwa
YH
Lee
Hye-suk
HS
Lee
Hyang-suk
HS
Kim
Han-suk
HS
Kim
D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D014280:Triglycerides / Q000097:blood*
D005217:Fat Emulsions, Intravenous; D008055:Lipids; D014280:Triglycerides