Catalytic hydrogenation of amino acids to amino alcohols with complete retention of configuration.
Rh-MoOx/SiO2 is an effective heterogeneous catalyst for selective hydrogenation of amino acids to amino alcohols in a water solvent. MoOx modification of Rh drastically enhanced the activity and improved the selectivity and ee. Various amino alcohols were obtained in high yields (90-94%) with complete retention of configuration.
Graduate School of Engineering, Tohoku University, Aoba 6-6-07, Aramaki, Aoba-ku, Sendai, 980-8579, Japan. tomi@erec.che.tohoku.ac.jp.
Masazumi
M
Tamura
Riku
R
Tamura
Yasuyuki
Y
Takeda
Yoshinao
Y
Nakagawa
Keiichi
K
Tomishige
D000596:Amino Acids / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D000596:Amino Acids; D000605:Amino Alcohols; D014867:Water; D012822:Silicon Dioxide; D008982:Molybdenum; D012238:Rhodium