Increased mean platelet volume in rheumatic mitral stenosis: assessment of clinical and echocardiographic determinants.
OBJECTIVE
The aim of this study was to investigate mean platelet volume (MPV) in patients with rheumatic mitral stenosis (RMS) and to define the determinants of a possible platelet activation reflected as platelet volume enlargement.


METHODS
Peripheral venous plasma value of MPV was measured in 84 consecutive patients (16 men, 68 women; mean age ± SD = 44 ± 13 years) with RMS who had no left atrial thrombus by transoesophageal echocardiography. The control group consisted of 32 healthy subjects (nine men, 23 women; mean age ± SD = 38 ± 7 years).


RESULTS
The patients had significantly higher MPV values (mean ± SD = 10.07 ± 0.58 fL) compared to the healthy subjects (mean ± SD = 8.15 ± 0.60 fL, p < 0.001). Among many clinical and echocardiographic variables, left atrial spontaneous echo contrast-positivity (beta = 0.426, p < 0.001) and severe mitral regurgitation (beta = 0.577, p < 0.001) appeared as significant predictors of platelet enlargement in RMS in multiple linear regression analysis.


CONCLUSIONS
Patients with RMS have increased platelet activity reflected as elevated MPV; and the coexistence of severe mitral regurgitation and presence of left atrial spontaneous echo contrast are determinants of this increment.
Ankara Numune Education and Research Hospital, Ankara, Turkey. maraspoli2020@gmail.com.
Mehmet
M
İleri
Selçuk
S
Kanat
Havva Tuğba
HT
Gürsoy
Deniz
D
Şahin
Pınar Türker
PT
Bayır
Gökhan
G
Şahin
Funda
F
Başyiğit
Özgül Uçar
ÖU
Elalmış
Ümit
Ü
Güray
D000328:Adult; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D008944:Mitral Valve Insufficiency; D008946:Mitral Valve Stenosis / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D012214:Rheumatic Heart Disease / Q000175:diagnosis / Q000473:pathology*