Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12.
Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).
Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand.
Sakdithep
S
Chaiyarit
Nilubon
N
Singhto
Yi-Ju
YJ
Chen
Chia-Ying
CY
Cheng
Wararat
W
Chiangjong
Rattiyaporn
R
Kanlaya
Henry H N
HH
Lam
Paleerath
P
Peerapen
Ting-Yi
TY
Sung
Phornpimon
P
Tipthara
Akhilesh
A
Pandey
Terence C W
TC
Poon
Yu-Ju
YJ
Chen
Ravi
R
Sirdeshmukh
Maxey C M
MC
Chung
Visith
V
Thongboonkerd
D002881:Chromosomes, Human, Pair 12 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009928:Organ Specificity; D020543:Proteome / Q000235:genetics* / Q000378:metabolism; D012107:Research Design
D020543:Proteome