Bacteriocins active against multi-resistant gram negative bacteria implicated in nosocomial infections.
Multiresistant Gram-negative bacteria are the prime mover of nosocomial infections. Some are naturally resistant to antibiotics, their genetic makes them insensitive to certain families of antibiotics and they transmit these resistors to their offspring. Moreover, when bacteria are subjected to antibiotics, they eventually develop resistance against drugs to which they were previously sensitive. In recent years, many bacteriocins active against gram-negative bacteria have been identified proving their efficacy in treating infections. While further investigation remains necessary before the possibilities for bacteriocins in clinical practice can be described more fully, this review provides an overview of bacteriocins acting on the most common infectious gram negative bacteria (Klebsiella, Acinetobacter, Pseudomonas aeruginosa and E. coli).
Hanen
H
Ghodhbane
Sabrine
S
Elaidi
Jean-Marc
JM
Sabatier
Sami
S
Achour
Jeannette
J
Benhmida
Higher Institute of Environmental Sciences and Technologies of Borj Cedria, University of Carthage, 1003 Hammam Lif, Tunisia. imed_regaya@yahoo.fr.
Imed
I
Regaya
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001430:Bacteriocins / Q000302:isolation & purification / Q000494:pharmacology*; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007778:Lactobacillus / Q000737:chemistry / Q000502:physiology; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001430:Bacteriocins