Three cases of mesalazine-induced pneumonitis with eosinophilia.
Oral mesalazine, or 5-aminosalicylate, is one of the first-choice medications for the treatment of ulcerative colitis and is commonly used for both induction and maintenance therapy. In a 6-month period, we treated three cases of mesalazine-induced pneumonitis. In all three cases, computed tomography images revealed upper lobe dominant bilateral peripherally localized consolidations. Such images are commonly observed in patients with cryptogenic organizing pneumonia or chronic eosinophilic pneumonia. Computed tomography images for mesalazine-induced pneumonitis have been rarely reported in the literature.
Department of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, 3-2-10, Kounandai, Kounan-ku, Yokohama 234-8503, Japan. Electronic address: miyon0312@hotmail.com.
Miyo
M
Inoue
Department of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, 3-2-10, Kounandai, Kounan-ku, Yokohama 234-8503, Japan. Electronic address: nobuyuki_horita@yahoo.co.jp.
Nobuyuki
N
Horita
Department of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, 3-2-10, Kounandai, Kounan-ku, Yokohama 234-8503, Japan. Electronic address: co.naoco@gmail.com.
Naoko
N
Kimura
Department of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, 3-2-10, Kounandai, Kounan-ku, Yokohama 234-8503, Japan. Electronic address: hrm@mvd.biglobe.ne.jp.
Ryota
R
Kojima
Department of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, 3-2-10, Kounandai, Kounan-ku, Yokohama 234-8503, Japan. Electronic address: nmiyazawa@dream.com.
Naoki
N
Miyazawa
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D019804:Mesalamine / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine
Adverse effects; Inflammatory bowel disease; Interstitial pneumonia; Ulcerative colitis