Primary small-cell neuroendocrine carcinoma of the male breast: a rare case report with review of the literature.
In this case study and review, we present a case of a primary small-cell neuroendocrine carcinoma (SCNC) of the male breast. Primary SCNC of the breast is a rare tumor with less than 30 cases reported in the literature. Most cases are found in women. Another exceptional point is that human epidermal growth factor receptor-2 (Her-2) immunoreactivity was positive in our recent case, which differed to previous reports detailing SCNC in women. We have no evidence to demonstrate the differences between treatment and prognoses for males and females, because we do not have sufficient cases to undertake an evidence-based investigation. We provide this rare case history; review the literature on SCNC of the breast; and discuss detailed information regarding epidemiology, histogenesis, clinical and histologic diagnosis criteria, surgical and adjuvant treatment, and prognosis.
Department of Breast Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Jian
J
Jiang
Department of Breast Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Guixin
G
Wang
Department of Pathology, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Li
L
Lv
Department of Breast Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Caigang
C
Liu
Department of Breast Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Xi
X
Liang
Department of Breast Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Haidong
H
Zhao
SCNC neoplasm; SMCC; male breast cancer; neuroendocrine; small-cell carcinoma