Continuous ultrasound-guided adductor canal block for total knee arthroplasty: a randomized, double-blind trial.
BACKGROUND
Adductor canal blocks have shown promise in reducing postoperative pain in total knee arthroplasty patients. No randomized, controlled studies, however, evaluate the opioid-sparing benefits of a continuous 0.2% ropivacaine infusion at the adductor canal. We hypothesized that a continuous adductor canal block would decrease postoperative opioid consumption.


METHODS
Eighty subjects presenting for primary unilateral total knee arthroplasty were randomized to receive either a continuous ultrasound-guided adductor canal block with 0.2% ropivacaine or a sham catheter. All subjects received a preoperative single-injection femoral nerve block with spinal anesthesia as is standard of care at our institution. Cumulative IV morphine consumption 48 hours after surgery was evaluated with analysis of covariance, adjusted for baseline characteristics. Secondary outcomes included resting pain scores (numeric rating scale), peak pain scores during physical therapy on postoperative days 1 and 2, quadriceps maximum voluntary isometric contraction, distance ambulated during physical therapy, postoperative nausea and vomiting, and satisfaction with analgesia.


RESULTS
Eighty subjects were randomized, and 76 completed the study per-protocol. The least-square mean difference in cumulative morphine consumption over 48 hours (block-sham) was--16.68 mg (95% confidence interval, -29.78 to -3.59, P = 0.013). Total morphine use between 24 and 48 hours (after predicted femoral nerve block resolution) also differed by least-square mean -11.17 mg (95% confidence interval,: -19.93 to -2.42, P = 0.013). Intention-to-treat analysis was similar to the per-protocol results. Functional outcomes revealed subjects in the adductor canal catheter group had better quadriceps strength (P = 0.010) and further distance ambulated (P = 0.034) on postoperative day 2.


CONCLUSIONS
A continuous adductor canal block for total knee arthroplasty reduces opioid consumption compared with that of placebo in the first 48 hours after surgery. Other outcomes including quadriceps strength, distance ambulated, and pain scores all show benefit from an adductor canal catheter after total knee arthroplasty but require further study before being interpreted as conclusive.
From the *Department of Anesthesiology, Virginia Mason Medical Center; †Department of Anesthesiology, Physicians Anesthesia Service, Seattle, Washington; and ‡Axio Research, Seattle, Washington.
Neil A
NA
Hanson
Cindy Jo
CJ
Allen
Lucy S
LS
Hostetter
Ryan
R
Nagy
Ryan E
RE
Derby
April E
AE
Slee
Alex
A
Arslan
David B
DB
Auyong
D000368:Aged; D000698:Analgesia; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D002404:Catheterization; D004311:Double-Blind Method; D004434:Early Ambulation; D005260:Female; D005267:Femoral Nerve / Q000000981:diagnostic imaging; D006801:Humans; D007432:Intraoperative Period; D007717:Knee / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D053580:Muscle Strength / Q000502:physiology; D009407:Nerve Block / Q000009:adverse effects / Q000379:methods*; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D009020:Morphine; D015742:Propofol