Comparative analysis of early and delayed cardioprotective and antiarrhythmic efficacy of hypoxic preconditioning.
Hypoxic preconditioning produces an infarct-limiting effect both in the early and delayed periods. The increase in heart resistance to ischemia-repefusion was more pronounced after early preconditioning. Hypoxic preconditioning did not change heart resistance to the arrhythmogenic effect of coronary occlusion and reperfusion.
Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, Maslov@cardio.tsu.ru.
L N
LN
Maslov
Yu B
YB
Lishmanov
A V
AV
Krylatov
A S
AS
Sementsov
A G
AG
Portnichenko
Yu K
YK
Podoksenov
I G
IG
Khaliulin
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000473:pathology; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D054059:Coronary Occlusion / Q000473:pathology; D006321:Heart; D000860:Hypoxia / Q000503:physiopathology*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents