HSC senescence upon irradiation.
In this issue of Blood, Shao et al report that a side effect of total body irradiation (TBI) is long-term bone marrow injury and thus dysfunctional hematopoiesis caused by the induction of hematopoietic stem cell (HSC) senescence. Interestingly and unexpectedly, however, this happens in a manner independent of the cell-cycle regulators Ink4a and Arf, which play a major role in senescence in other cell systems.
ULM UNIVERSITY; CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER.
Hartmut
H
Geiger
D000818:Animals; D001853:Bone Marrow / Q000473:pathology* / Q000528:radiation effects*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000473:pathology* / Q000528:radiation effects*
C417743:Cdkn2a protein, mouse; D019941:Cyclin-Dependent Kinase Inhibitor p16