Palladium-catalyzed direct addition of 2-aminobenzonitriles to sodium arylsulfinates: synthesis of o-aminobenzophenones.
The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Jiuxi
J
Chen
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. lijjun@126.com.
Jianjun
J
Li
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. pharmlab@zjut.edu.cn.
Weike
W
Su
D001190:Arylsulfonates / Q000737:chemistry*; D001577:Benzophenones / Q000138:chemical synthesis*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D009570:Nitriles / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
D001190:Arylsulfonates; D001577:Benzophenones; D009570:Nitriles; C540240:o-aminobenzonitrile; D010165:Palladium