Effect of intraperitoneal administered ginseng total saponins on hyperalgesia induced by repeated intramuscular injection of acidic saline in rats.
The aim of this study was to assess the antinociceptive activity of ginseng total saponins (GTS) on hyperalgesia induced by repeated intramuscular injections of acidic saline in rats and to examine the mechanisms involved. Rats were injected intraperitoneally with a 0.9% saline vehicle or various doses of GTS after the development of hyperalgesia. Rats were then injected with N-methyl-D-aspartate (NMDA) or naloxone 10 min before GTS injection. The mechanical withdrawal threshold (MWT) was assessed with von Frey filaments. The MWT was significantly increased after intraperitoneal injection of 100 mg/kg and 200 mg/kg of GTS when compared with the MWT after the development of hyperalgesia. Injection of GTS with NMDA showed a significant decrease in the MWT when compared with GTS injection. GTS showed an antinociceptive activity against chronic muscle-induced pain, and the effect of GTS may be mediated by NMDA.
1 Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul , Korea.
Won Joong
WJ
Kim
Hyun
H
Kang
Jung Eun
JE
Kim
Geun Joo
GJ
Choi
Hwa Yong
HY
Shin
Chong Wha
CW
Baek
Yong Hun
YH
Jung
Young Choel
YC
Woo
Su Hyun
SH
Kim
Jeong Hyuk
JH
Lee
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007273:Injections, Intramuscular; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects*; D016202:N-Methylaspartate / Q000494:pharmacology; D017288:Pain Threshold / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012965:Sodium Chloride
D000700:Analgesics; D010936:Plant Extracts; D016194:Receptors, N-Methyl-D-Aspartate; D012503:Saponins; D012965:Sodium Chloride; D016202:N-Methylaspartate
Panax ginseng; acid; chronic; hyperalgesia; muscle