Serum leptin and adiponectin levels in Korean patients with psoriasis.
Psoriasis is a disorder caused by genetic and immunological factors. Leptin, a peptide hormone secreted predominantly from adipose tissue, regulates energy intake and expenditure, as well as the T-helper response. There have been conflicting reports regarding serum levels of leptin and adiponectin in patients with psoriasis. In the present study, we measured serum levels of leptin and adiponectin in Korean patients with psoriasis. Twenty-four patients with psoriasis and fifteen control subjects were included in the study. Serum leptin and adiponectin levels were determined by an immunometric sandwich enzyme-linked immunosorbent assay (ELISA). The mean serum leptin concentration in patients with psoriasis was higher than in controls, and the difference was statistically significant. In contrast, serum adiponectin levels in patients with psoriasis were significantly decreased compared with healthy controls. Leptin levels in vitamin D-deficient patients were statistically significantly higher than in vitamin D-sufficient patients. Serum adiponectin concentrations showed a negative correlation with body mass index (BMI) and psoriasis area and severity index (PASI) in patients with psoriasis. In conclusion, the present study demonstrated that leptin and adiponectin may play a role in the immunopathogenesis of psoriasis and may be useful biomarkers indicating severity of psoriasis in Korean patients.
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Yu Jin
0000-0001-8248-988X
YJ
Oh
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Hee Kyeong
0000-0002-3974-4571
HK
Lim
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Jeong Hwee
0000-0003-0270-9948
JH
Choi
Medical Science Research Institute, Kyung Hee University Medical Center, Seoul, Korea.
Jin Woo
0000-0003-0390-7954
JW
Lee
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Nack In
0000-0002-4810-7013
NI
Kim
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology*; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk; D012720:Severity of Illness Index; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*; D055815:Young Adult
D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D014807:Vitamin D
Adiponectin; Leptin; Metabolic Syndrome; Psoriasis