Exploration of the association between chronic periodontal disease and erectile dysfunction from a population-based view point.
Several cross-sectional studies have indicated an association between chronic periodontal disease (CPD) and cardiovascular disease and metabolic syndrome. Erectile dysfunction (ED) also shares pathological mechanisms with these diseases. Using a nationwide population-based data set, we examined the association between ED and CPD and assessed the effect of dental extraction (DE) on ED prevalence in different aged CPD populations in Taiwan. We identified 5105 patients with ED and randomly selected 10 210 patients as controls. Of these patients, 2617 (17.09%) were diagnosed with CPD according to the index data: 1196 (23.43%) in the ED group and 1421 (13.92%) in the control group. After adjusting for comorbid factors, patients with ED were more likely to have been diagnosed with prior CPD than controls (OR = 1.79, 95% CI = 1.64-1.96, P < 0.001). Moreover, the association was much stronger in the populations aged less than 30 years (OR = 2.13, 95% CI = 1.23-3.70, P < 0.001) and more than 59 years (OR = 2.27, 95% CI = 1.99-2.59, P < 0.001). Dental extraction seems to attenuate damage to the penile endothelial beds caused by CPD-related inflammation and overcame the process of ED in the middle-aged and older populations.
Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Biomedical Informatics, and Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan.
C-W
CW
Tsao
C-Y
CY
Liu
T-L
TL
Cha
S-T
ST
Wu
S-C
SC
Chen
C-Y
CY
Hsu
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D002908:Chronic Disease; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D007172:Erectile Dysfunction / Q000453:epidemiology*; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D016017:Odds Ratio; D010510:Periodontal Diseases / Q000453:epidemiology / Q000601:surgery; D010518:Periodontitis / Q000453:epidemiology* / Q000601:surgery; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology; D014081:Tooth Extraction / Q000379:methods; D055815:Young Adult
Dental extraction; endothelial function; erectile dysfunction; periodontal disorder