Delivering the second revolution in site-specific nucleases.
Viruses have been used to deliver two types of site-specific nucleases into cells for targeted gene editing.
Perry B Hackett is in the Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States hacke004@umn.edu.
Perry B
PB
Hackett
Nikunj V Somia is in the Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States.
Nikunj V
NV
Somia
D004720:Endonucleases / Q000096:biosynthesis*; D005818:Genetic Engineering / Q000379:methods*; D005822:Genetic Vectors; D015894:Genome, Human; D006801:Humans; D016086:Lentivirus / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis*; D014161:Transduction, Genetic; D014162:Transfection / Q000379:methods*
D014157:Transcription Factors; D004720:Endonucleases
gag; gene therapy; lentiviral vector; protein transduction; transcription activator-like effector nucleases; zinc-finger nucleases