PRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes.
The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.
Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, 34450 Istanbul, Turkey.
Alper
A
Baspinar
Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, 34450 Istanbul, Turkey.
Engin
E
Cukuroglu
National Cancer Institute, Cancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., National Cancer Institute, Frederick, MD 21702, USA Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Ruth
R
Nussinov
Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, 34450 Istanbul, Turkey agursoy@ku.edu.tr okeskin@ku.edu.tr.
Ozlem
O
Keskin
Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, 34450 Istanbul, Turkey agursoy@ku.edu.tr okeskin@ku.edu.tr.
Attila
A
Gursoy
D000465:Algorithms; D020407:Internet; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry*; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D012984:Software
D046912:Multiprotein Complexes