Anti-inflammatory and antipyretic properties of the rhizome of costus speciosus (koen.) sm.
Rhizome of Costus speciosus has been traditionally used for treating inflammatory and painful conditions. The objective of the present study was to provide a scientific basis for the traditional use. The ethanolic extract of the rhizome of Costus speciosus possesses anti-inflammatory and antipyretic properties. Antiinflammatory property was studied in carrageenan induced paw edema and cotton pellet induced granuloma formation. Significant anti-inflammatory effect was found against carrageenan induced edema formation in rats at a dose of 800 mg/kg and against cotton pellet granuloma formation in rats at doses of 400 mg/kg and 800 mg/kg. The antipyretic property was studied in yeast-induced pyrexia in rats. The antipyretic effect was only minimal and was observed only at 800 mg/kg dose.
Melmaruvathur Adhiparasakthi Institute of Medical Sciences & Research, Melmaruvathur, Tamilnadu, India.
K
K
Binny
Government Medical College, Kottayam, Kerala, India.
Sunil G
SG
Kumar
Dr Reddy's Laboratories Ltd, Hyderabad, Andhra Pradesh, India.
Thomas
T
Dennis
Carrageenan; Cotton pellet granuloma; Paw edema; Pyrexia model; Screening methods