Atypical antipsychotic drugs inhibit trabecular bone accrual in C57BL/6J mice.
OBJECTIVE
To investigate the effects of the atypical antipsychotics drugs (AADs), olanzapine and risperidone, on femoral bone characteristics in female C57BL/6J mice.


METHODS
Mice were treated with placebo or AADs (olanzapine or risperidone) for 3-4 weeks. Femoral cortical and trabecular bone characteristics were determined using micro-computed tomography.


RESULTS
Olanzapine-treated mice tended to have lower trabecular bone volume (P= 0.088) and connectivity (P= 0.057) but no significant differences in bone density (P= 0.521) relative to controls. Risperidone-treated mice had significantly lower trabecular bone density (P= 0.001) and volume (P= 0.008), bone volume/total volume (P= 0.001), connectivity (P= 0.007), and trabecular number (P= 0.003) relative to controls. Cortical bone was not significantly affected by olanzapine or risperidone treatment.


CONCLUSIONS
AADs inhibited trabecular bone accrual in C57BL/6J mice suggesting that alternative treatment options may need to be considered for the schizophrenia patient with potential osteoporosis risk.
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Xingsheng
X
Li
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Tim R
TR
Nagy
cortical bone; olanzapine; risperidone; trabecular bone