Postnatally diagnosed agenesis of corpus callosum in fetuses.
OBJECTIVE
To examine and characterize the agenesis of the corpus calosum (ACC) in an epidemiological study of fetal autopsies, as well as, to analyze the associated anomalies and to emphasize the importance of the clinical examination of ACC.


METHODS
The subjects of observation are 20 fetuses from a total of 2238 autopsies carried out during a period of three years (2006-2009) in Tunis.


RESULTS
The associated abnormalities are hydrocephalus, cerebellar hypoplasia, agenesis of vermis cerebelli, polymicrogyria and lissencephaly. Sixteen of the cases (80%) are syndromic: Trisomy 13,18,21 (5,1,2 fetuses respectively) and Thanatophoric dysplasia, Fetal akinesia syndrome, Dandy-Walker Malformation and the Association VACTERL are represented by two cases each.


CONCLUSIONS
The prenatal diagnosis of ACC must be the result of a multidisciplinary approach. The phenotype of the XLAG syndrome creates an interest to study asymptomatic patients with ACC, especially when the anomaly is detected prenatally.
1Department of Anatomy, Histology and Embryology, Medical University of Plovdiv, Plovdiv, Bulgaria.
Tanya Todorova
TT
Kitova
Borislav
B
Kitov
Denis
D
Milkov
Soumeya
S
Gaigi
D000015:Abnormalities, Multiple / Q000473:pathology; D037881:Aborted Fetus / Q000473:pathology*; D000328:Adult; D061085:Agenesis of Corpus Callosum / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D001344:Autopsy; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D055815:Young Adult
Corpus callosum; XLAG syndrome; splenium corporis callosi