Garlic-derived allyl sulfides in cancer therapy.
Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.
Hai-Xia
HX
Cao
Ke-Xiang
KX
Zhu
Jian-Gao
JG
Fan
Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of medicine, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China. fanjiangao@gmail.com.
Liang
L
Qiao
D000498:Allyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013440:Sulfides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000498:Allyl Compounds; D000972:Antineoplastic Agents, Phytogenic; D013440:Sulfides; C038491:allyl sulfide