Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy.
Helicobacter pylori (H. pylori) infects the human stomach during infancy and develops into chronic active inflammation. The majority of H. pylori tend to colonize within the mucous gel layer of the stomach. The stomach lacks its own immune function, thus innate immunity as the first line of defense is vital for specific immunity against H. pylori. We review recent discoveries in the pathophysiologic roles of toll-like receptors (TLRs), mainly TLR2 and TLR4, in H. pylori-induced inflammation. In addition, the TLR pathways activated by H. pylori-induced inflammation have been shown to be closely associated not only with gastric carcinogenesis, but also with formation of the tumor microenvironment through the production of pro-inflammatory cytokines, chemokines, and reactive oxygen species. Although the correlation between single nucleotide polymorphisms of TLRs and gastric cancer risk remains unclear, a recent study demonstrated that STAT3-driven up-regulation of TLR2 might promote gastric tumorigenesis independent of inflammation. Further research on the regulation of TLRs in H. pylori-associated gastric carcinogenesis will uncover diagnostic/predictive biomarkers and therapeutic targets for gastric cancer.
Kaname Uno, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University, Miyagi 981-8574, Japan.
Kaname
K
Uno
Kaname Uno, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University, Miyagi 981-8574, Japan.
Katsuaki
K
Kato
Kaname Uno, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University, Miyagi 981-8574, Japan.
Tooru
T
Shimosegawa
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology; D015398:Signal Transduction; D013270:Stomach / Q000276:immunology* / Q000382:microbiology; D013274:Stomach Neoplasms / Q000276:immunology* / Q000382:microbiology; D051193:Toll-Like Receptors / Q000276:immunology*; D059016:Tumor Microenvironment
D018836:Inflammation Mediators; D051193:Toll-Like Receptors
Damage-associated molecular patterns; Gastric cancer; Helicobacter pylori; Pathogen-associated molecular patterns; Toll like receptors