Protein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.
BACKGROUND
Both eukaryotic translation initiation factor 4E (eIF4E) and integrin αvβ6 play an important role in the development and progression of cancer. The aim of this study was to investigate the expression of eIF4E and Integrin αvβ6, their clinical significance as well as the two proteins' correlation in colonic carcinoma tissues.


RESULTS
The expression levels of eIF4E and integrin αvβ6 were analyzed in colon cancerous and paraneoplastic tissues of 138 cases via tissue microarray (TMA)- immunohistochemistry. And their clinical significance as well as the two proteins' correlation was also investigated. The expression of eIF4E was significantly associated with clinical TNM stage (P = 0.009), while T stage (P = 0.011) and TNM stage (P = 0.012) were significantly associated with integrin αvβ6 expression. Moderately weak correlation exists between the two proteins (r =0.299, P <0.001). The survival analysis by Kaplan-Meier and Cox regression model showed that protein expression of high eIF4E and positive integrin αvβ6, as independent prognostic factors (RR = 2.417, P = 0.001 and RR = 2.393, P = 0.001), tended to have a significantly poorer 5-year survival rate (P = 0.013 and 0.025, respectively, the log-rank test).


CONCLUSIONS
eIF4E and Integrin αvβ6 were indicators of tumor's progression and poor prognosis of patients with colon cancer. And the potential signaling loop involving them may provide a helpful therapeutic target in prevention and treatment of colon cancer.
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, Shandong 250012, PR China.
Zhengchuan
Z
Niu
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Jiayong
J
Wang
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, Shandong 250012, PR China.
Shahbaz
S
Muhammad
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Weibo
W
Niu
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Enyu
E
Liu
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Cheng
C
Peng
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, Shandong 250012, PR China.
Benjia
B
Liang
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, Shandong 250012, PR China.
Qi
Q
Sun
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Shinichi
S
Obo
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Zhaobin
Z
He
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Song
S
Liu
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, Shandong 250012, PR China.
Xueqing
X
Zou
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China.
Jun
J
Niu
Colon cancer; ERK; Integrin αvβ6; TMA; eIF4E; mTOR