Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment.
OBJECTIVE
Military deployment can have profound effects on physical and mental health. Few studies have examined whether interventions prior to deployment can improve mechanisms underlying resilience. Mindfulness-based techniques have been shown to aid recovery from stress and may affect brain-behavior relationships prior to deployment. The authors examined the effect of mindfulness training on resilience mechanisms in active-duty Marines preparing for deployment.


METHODS
Eight Marine infantry platoons (N=281) were randomly selected. Four platoons were assigned to receive mindfulness training (N=147) and four were assigned to a training-as-usual control condition (N=134). Platoons were assessed at baseline, 8 weeks after baseline, and during and after a stressful combat training session approximately 9 weeks after baseline. The mindfulness training condition was delivered in the form of 8 weeks of Mindfulness-Based Mind Fitness Training (MMFT), a program comprising 20 hours of classroom instruction plus daily homework exercises. MMFT emphasizes interoceptive awareness, attentional control, and tolerance of present-moment experiences. The main outcome measures were heart rate, breathing rate, plasma neuropeptide Y concentration, score on the Response to Stressful Experiences Scale, and brain activation as measured by functional MRI.


RESULTS
Marines who received MMFT showed greater reactivity (heart rate [d=0.43]) and enhanced recovery (heart rate [d=0.67], breathing rate [d=0.93]) after stressful training; lower plasma neuropeptide Y concentration after stressful training (d=0.38); and attenuated blood-oxygen-level-dependent signal in the right insula and anterior cingulate.


CONCLUSIONS
The results show that mechanisms related to stress recovery can be modified in healthy individuals prior to stress exposure, with important implications for evidence-based mental health research and treatment.
Douglas C
DC
Johnson
Nathaniel J
NJ
Thom
Elizabeth A
EA
Stanley
Lori
L
Haase
Alan N
AN
Simmons
Pei-An B
PA
Shih
Wesley K
WK
Thompson
Eric G
EG
Potterat
Thomas R
TR
Minor
Martin P
MP
Paulus
D001921:Brain / Q000502:physiology; D059907:Functional Neuroimaging; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008889:Military Personnel / Q000523:psychology*; D064866:Mindfulness; D009478:Neuropeptide Y / Q000097:blood; D055500:Resilience, Psychological; D012119:Respiration; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D055815:Young Adult
D009478:Neuropeptide Y