A case of giant intracranial tuberculoma in an infant: clinical and radiologic pitfalls.
Intracranial tuberculoma in infants are a rare occurrence. We report a 7-month-old male infant presenting to our tertiary care referral center with complaints of global developmental delay and right hemiparesis for 3 months. Radiologic imaging was suggestive of large left frontoinsular space-occupying lesion with initial differential of primitive neuroectodermal tumor or desmoplastic infantile ganglioglioma. Considering the clinicoradiologic findings and no history suggestive of immunodeficiency or contact with tuberculosis, surgical decompression was done. Final histopathology revealed multiple epithelioid granulomas suggestive of tubercular etiology or intracranial Langerhans cell histiocytosis. He was started on antitubercular therapy after ruling out Langerhans cell histiocytosis using CD1a and Langerin immunohistochemistry staining. Interpretation of tuberculous etiology in infants can be challenging for clinicians, radiologists, and pathologists. A high index of suspicion is necessary to diagnose such lesions, predominantly in endemic regions.
Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi, India.
Amol
A
Raheja
Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi, India sumitneuro@gmail.com.
Sumit
S
Sinha
Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi, India.
Mukund Namdev
MN
Sable
Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi, India.
Mehar Chand
MC
Sharma
Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi, India.
Bhawani Shankar
BS
Sharma
D004848:Epithelium / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D016862:Tuberculoma, Intracranial / Q000000981:diagnostic imaging* / Q000628:therapy*
glioma; infant; intracranial; mimicking; tuberculoma