Development of novel, alternative, facile, ecofriendly, high yield synthetic process for prazosin.
Industrial chemistry in the new millennium is widely adopting the concept of "Green chemistry" to meet the fundamental scientific challenges. Antihypertensive drugs include several of the most widely prescribed drugs like diuretics, beta-blockers, ACE inhibitors, calcium channel blockers, and α-1 adrenoreceptor blockers. The discovery of prazosin, with very high index of α1/α2 affinity has triggered off a renaissance of interest in α1-adrenoceptor antagonist drugs for treatment of hypertension. The three reported routes for synthesis and manufacture of the α-adrenoceptor antagonist- prazosin had some disadvantages. In present study we had developed new methods for the synthesis of prazosin by using microwave. The most important aspect is the overall yield of this process was ~25 % higher than the other reported methods excluding the use of banned substances.
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur - 425 405, Dhule, Maharashtra, India.
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Patil
Department of Pharmaceutical Chemistry, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune - 411 041, India.
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Jain
Department of Pharmaceutical Chemistry, S.G.R.S. College of Pharmacy, Saswad, Pune - 411 025, India.
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Deodhar
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur - 425 405, Dhule, Maharashtra, India.
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Patil
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur - 425 405, Dhule, Maharashtra, India.
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Patil
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur - 425 405, Dhule, Maharashtra, India.
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Patil
green chemistry; prazosin; process development