HIV drug resistance in newly diagnosed adults in a rural prefecture of eastern China.
Little is known about HIV drug resistance (HIVDR) in newly diagnosed HIV-infected adults in eastern China where the HIV epidemic is spreading predominantly through sexual contact. During 2008-2011, newly HIV-diagnosed adults in Taizhou prefecture, Zhejiang province in eastern China were examined for HIVDR by amplifying and sequencing the HIV-1 pol gene. Of 447 genotyped participants, 53·7% were infected with CRF01_AE, 20·1% with CRF07_BC, 12·5% with subtype B, and 11·6% with CRF08_BC. Most of the participants had one or more minor genetic mutations in the pol gene that are associated with HIVDR. Twelve (2·7%) participants met the standard guidelines of having low to high HIVDR, suggesting that the prevalence of HIVDR in newly HIV-diagnosed adults was low in the study area and current antiretroviral therapy (ART) regimens are likely to remain effective. However, given high frequency of minor HIVDR in HIV patients and the scaling up of ART programmes in China, larger HIVDR surveillance programmes are needed.
Department of Epidemiology, School of Public Health,Fudan University,and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai,China.
J
J
Hua
Department of Epidemiology, School of Public Health,Fudan University,and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai,China.
H
H
Lin
Department of Epidemiology, School of Public Health,Fudan University,and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai,China.
Y
Y
Ding
Taizhou City Center for Disease Control and Prevention,Zhejiang Province,China.
D
D
Qiu
Department of Behavioral Sciences and Health Education, Rollins School of Public Health,Emory University,Atlanta, GA,USA.
F
F
Wong
Department of Epidemiology, School of Public Health,Fudan University,and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai,China.
N
N
He
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D015995:Prevalence; D012424:Rural Population; D017422:Sequence Analysis, DNA; D055815:Young Adult; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
D054302:pol Gene Products, Human Immunodeficiency Virus
Antiretroviral therapy (ART); China; HIV drug resistance; transmission