Characteristic Findings of Primary Sclerosing Cholangitis on Endoscopic Retrograde Cholangiography: Which is the Most Common Finding?
BACKGROUND
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease and one of the most common indications for liver transplantation in adults. There are conflicting data regarding characteristic findings of PSC disease on endoscopic retrograde cholangiography (ERCP). We undertook this study to clarify whether there is a specific pattern of involvement of the biliary tract in patients with PSC and to evaluate features of PSC disease on ERCP in order to be able to manage this disease better.


METHODS
This retrospective study included 45 patients admitted to Taleghani Hospital in 2004-2010 and diagnosed to have PSC on the basis of typical cholangiographic findings in combination with clinical and laboratory data. Patients suspected to have secondary sclerosing cholangitis were excluded. Demographic and clinical data were recorded, along with cholangiographic findings and the frequency of large duct and small duct PSC.


RESULTS
Forty-five patients of mean age 34.8 (range 15-66) years were included. Twenty-nine patients (64.4%) had inflammatory bowel disease, and the frequency of large duct PSC and small duct PSC was 93.4% and 6.6%, respectively. The intrahepatic ducts alone were involved in 11 (24.4%) patients and the extrahepatic ducts were involved in 14 (31.1%), with 17 (37.7%) patients having both intrahepatic and extrahepatic PSC. Three (6.6%) patients did not have bile duct involvement on ERCP, and their disease was diagnosed by liver biopsy as small duct PSC. The most common type of cholangiographic feature of intrahepatic duct involvement was type 2, found in 15 (33.3%) patients, with type 3 being the most common type of extrahepatic duct involvement and detected in 16 (35.5%) patients.


CONCLUSIONS
Our study demonstrates that the most common PSC finding on ERCP is involvement of both the extrahepatic and intrahepatic bile ducts, with small duct PSC being less common than large duct PSC.
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Amir Houshang
AH
Mohammad Alizadeh
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Anahita
A
Shahnazi
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Aida
A
Rasoulzadeh
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Esmaeel
E
Shams
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Manijeh
M
Mohammadi
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Farideh
F
Darabi
Department of Internal Medicine, Division of Gastroenterology and Liver Diseases, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Mahnaz
M
Behdad
endoscopic retrograde cholangiopancreatography; large duct; primary sclerosing cholangitis; small duct