Paper-based DNA detection using lanthanide-doped LiYF4 upconversion nanocrystals as bioprobe.
A novel sensitive DNA bioassay using lanthanide-doped LiYF4 upconversion nanocrystals as luminescent marker and oligonucleotide hybridization as the selective reaction is developed in a paper-based platform, providing a detection limit of 3.6 fmol.
Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto, 3359 Mississauga Road, Mississauga Ontario, Canada, L5L 1C6.
Qiang
Q
Ju
Uvaraj
U
Uddayasankar
Ulrich
U
Krull
D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008027:Light; D057230:Limit of Detection; D049449:Luminescence; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009841:Oligonucleotides / Q000737:chemistry; D055095:Optics and Photonics; D010209:Paper; D017785:Photons; D012542:Scattering, Radiation; D019265:Spectroscopy, Near-Infrared; D014961:X-Ray Diffraction
D028581:Lanthanoid Series Elements; D009841:Oligonucleotides; D004247:DNA
DNA detection; bioprobes; paper-based; upconversion