Reading RNA methylation codes through methyl-specific binding proteins.
N (6)-methyladenosine (m (6)A) is a prevalent modification of eukaryotic mRNAs. It regulates yeast cell fate and is essential to the development and fertility of metazoans. Although its presence in mRNA has been known since the early 1970s, the function of m (6)A remained a mystery until the spate of discoveries in the past three years. Here, we focus on the discovery of m (6)A "readers" (proteins that specifically recognize m (6)A), and their functions in tuning mRNA stability, as well as the broader significance of such m (6)A-dependent regulation of gene expression.
Department of Chemistry and Institute for Biophysical Dynamics; The University of Chicago; Chicago, IL USA.
Xiao
X
Wang
Department of Chemistry and Institute for Biophysical Dynamics; The University of Chicago; Chicago, IL USA.
Chuan
C
He
D005786:Gene Expression Regulation; D006801:Humans; D008745:Methylation; D054730:Protein Interaction Domains and Motifs; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
D012333:RNA, Messenger; D016601:RNA-Binding Proteins
N6-methyladenosine; RNA methylation; RNA stability; RNA-binding protein; YTH domain; YTHDF2; gene expression regulation; m6A; reversible RNA modification