Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration.
1,4-Metal migrations enable the remote functionalization of C-H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the iridium-catalyzed arylative cyclization of alkynones with arylboronic acids is described. To our knowledge, these reactions involve the first reported examples of 1,4-iridium migration.
EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ (UK) http://www.nottingham.ac.uk/∼pczhl; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK).
Benjamin M
BM
Partridge
Jorge
J
Solana González
Hon Wai
HW
Lam
CH activation; alkynes; boron; catalysis; iridium