The relationship between pediatric combination vaccines and market effects.
We explored market factors that affect pediatric combination vaccine uptake in the US public-sector pediatric vaccine market. We specifically examined how Pediarix and Pentacel earned a place in the 2009-2012 lowest overall cost formulary. Direct competition between Pediarix and Pentacel is driven by the indirect presence of the Merck Haemophilus influenzae type b vaccine and the Recommended Childhood Immunization Schedule requirement for a hepatitis B birth dose. The resulting analysis suggests that Pentacel would never have earned a place in the lowest overall cost formulary for 2009-2012 federal contract prices for any cost of an injection unless the Merck H influenzae type b advantage was ignored and the hepatitis B birth dose administration cost was recognized by health care providers in designing the lowest overall cost formularies.
Banafsheh Behzad is with the Department of Industrial and Enterprise Systems Engineering, University of Illinois at Urbana-Champaign. Sheldon H. Jacobson is with the Department of Computer Science, University of Illinois at Urbana-Champaign. Janet A. Jokela is with College of Medicine, University of Illinois at Urbana-Champaign. Edward C. Sewell is with the Department of Mathematics and Statistics, Southern Illinois University, Edwardsville.
Banafsheh
B
Behzad
Sheldon H
SH
Jacobson
Janet A
JA
Jokela
Edward C
EC
Sewell
D002648:Child; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000191:economics* / Q000627:therapeutic use; D016527:Drug Costs; D004345:Drug Industry / Q000191:economics; D018073:Haemophilus Vaccines / Q000191:economics* / Q000627:therapeutic use; D017325:Hepatitis B Vaccines / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D017589:Immunization Programs / Q000191:economics; D007223:Infant; D007231:Infant, Newborn; D011054:Poliovirus Vaccine, Inactivated / Q000191:economics* / Q000627:therapeutic use; D014481:United States; D017778:Vaccines, Combined / Q000191:economics / Q000627:therapeutic use
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D017325:Hepatitis B Vaccines; C472675:PEDIARIX; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined; C512971:pentacel