Squatting and risk of colorectal cancer:a case-control study.
BACKGROUND The sitting position, rather than squatting, during defecation has been hypothesized to be a risk factor for colorectal cancer (CRC). METHODS We conducted a case-control study to test this hypothesis.A total of 100 CRC cases from two hospitals in Iran and 100 control subjects, selected from the coronary care unit (CCU) of those same hospitals were selected for this study. We administered a detailed questionnaire to the study subjects asking about history of toilet use and other relevant confounders. RESULTS In logistic regression analysis, the crude and adjusted ORs (95% CIs) for using sitting toilets in any decade were 1.20 (0.89 - 1.61) and 1.07 (0.72 - 1.59), respectively. Also, the crude and adjusted ORs (95% CIs) for using 10 more years of sitting toilets were as 1.16 (0.92 - 1.47) and 1.02 (0.74 - 1.40), neither of which indicated a statistically significant increase in risk. CONCLUSION Our study did not support an appreciable role for using sitting toilets as risk factors for CRC.
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Sahand
S
Sohrabi
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Reza
R
Malekzadeh
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Reza
R
Ansari
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, USA.
Farin
F
Kamangar
Cancer; Case-control; Colon; Colorectal; Iran; Rectal; Risk factor