Synthesis of α-trifluoromethyl ketones via the Cu-catalyzed trifluoromethylation of silyl enol ethers using an electrophilic trifluoromethylating agent.
A method has been developed for the synthesis of α-trifluoromethyl ketones via the Cu-catalyzed trifluoromethylation of silyl enol ethers with an electrophilic trifluoromethylating agent, which produces a trifluoromethyl radical.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, P. R. of China.
Lun
L
Li
Qing-Yun
QY
Chen
Yong
Y
Guo
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated; D007659:Ketones / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D012821:Silanes