The Golgi is a measuring cup.
The relation of organelle size to cellular function is a basic question in cell biology about which almost nothing is known. Reporting in this issue of Developmental Cell, Ferraro et al. (2014) show that the size and topology of the Golgi apparatus determines the size and functionality of a medically important secretory granule.
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: wallace.marshall@ucsf.edu.
Wallace F
WF
Marshall
D061307:Human Umbilical Vein Endothelial Cells / Q000502:physiology*; D006801:Humans; D020302:Weibel-Palade Bodies / Q000502:physiology*; D021601:trans-Golgi Network / Q000378:metabolism*; D014841:von Willebrand Factor / Q000502:physiology*
D014841:von Willebrand Factor