[12Ala polymorphism of receptor gene, which activates proliferation by peroxisome ά2, determines severity of bronchial asthma course associated with coronary heart disease].
The aim of the research was to detect the role of PPAR-γ2 gene Pro12Ala polymorphism in the development of bronchial asthma (BA) in combination with coronary heart disease (CHD). BA patients in combination with coronary artery disease were examined in terms of anthropometric measurements, lung function, cycle ergometry, ECG, blood pressure, and endothelium-independent vasodilatation. The alleles of PPAR-γ2 gene polymorphic region were determined; the high-sensitivity C-reactive protein (hs-CRP) and the adhesion molecules sVCAM-1 and sICAM-1 in the blood were detected; the biochemical blood analysis was performed. It was found that patients with Ala allele in homo-and heterozygous state, as opposed to patients with Pro allele in homozygous variant, reveal a significantly higher incidence of first grade arterial hypertension and mild persistent BA; lower rates of heart rate were recorded; significantly higher levels of parameters characterizing the systemic inflammation (white blood cell count and hsCRP) and lower rates of adhesion molecules of sICAM-1 level, total cholesterol, total and indirect bilirubin were detected. Ala allele carriers in homo- and heterozygous state in patients with BA in combination with CHD is associated with the risk of overweight, mild persistent asthma and angina I FC. Thus, the carrier state of 12Ala allele of PPAR-γ2 gene Pro12Ala polymorphism may be associated with a higher risk of developing BA against the background of CHD.
D000328:Adult; D001249:Asthma / Q000209:etiology / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D047495:PPAR gamma; D019010:Vascular Cell Adhesion Molecule-1; D002097:C-Reactive Protein; D002784:Cholesterol