Development of the lateral line canal system through a bone remodeling process in zebrafish.
The lateral line system of teleost fish is composed of mechanosensory receptors (neuromasts), comprising superficial receptors and others embedded in canals running under the skin. Canal diameter and size of the canal neuromasts are correlated with increasing body size, thus providing a very simple system to investigate mechanisms underlying the coordination between organ growth and body size. Here, we examine the development of the trunk lateral line canal system in zebrafish. We demonstrated that trunk canals originate from scales through a bone remodeling process, which we suggest is essential for the normal growth of canals and canal neuromasts. Moreover, we found that lateral line cells are required for the formation of canals, suggesting the existence of mutual interactions between the sensory system and surrounding connective tissues.
Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan. Electronic address: hiwada@nig.ac.jp.
Hironori
H
Wada
Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Miki
M
Iwasaki
Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan; Department of Genetics, Graduate University for Advanced Studies (SOKENDAI), 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Koichi
K
Kawakami
D000469:Alkaline Phosphatase / Q000096:biosynthesis / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000196:embryology; D047108:Embryonic Development; D034582:Integumentary System; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D053403:Lateral Line System / Q000166:cytology* / Q000196:embryology*; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000235:genetics; D000076182:Sp7 Transcription Factor; D014157:Transcription Factors / Q000096:biosynthesis; D060449:Wnt Signaling Pathway; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
C000590647:DKK2 protein, zebrafish; D036341:Intercellular Signaling Peptides and Proteins; D000076182:Sp7 Transcription Factor; D014157:Transcription Factors; D029961:Zebrafish Proteins; C541742:sp7 protein, zebrafish; D016186:Receptor, Macrophage Colony-Stimulating Factor; D000469:Alkaline Phosphatase
Bone remodeling; Lateral line; Neuromast; Organ growth; Scale; Zebrafish