Effect of Centella asiatica on oxidative stress and lipid metabolism in hyperlipidemic animal models.
Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model. It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels. L-CAT and SR-BI gene expression in hamsters were increased. Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties.
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China ; Xiamen Key Laboratory of Chiral Drugs, Xiamen 361000, China.
Yun
Y
Zhao
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China.
Ping
P
Shu
College of Pharmacy, Hubei University of Science and Technology, Xianning 437000, China.
Youzhi
Y
Zhang
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China.
Limin
L
Lin
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China.
Haihong
H
Zhou
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China.
Zhentian
Z
Xu
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China.
Daqin
D
Suo
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China.
Anzhi
A
Xie
Medical College, Xiamen University, Xiang'an District, Xiamen 361000, China ; Xiamen Key Laboratory of Chiral Drugs, Xiamen 361000, China.
Xin
X
Jin
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism; D028041:Centella / Q000737:chemistry* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D018955:CD36 Antigens; C526146:Centella asiatica extract; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D014315:Triterpenes; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D007862:Phosphatidylcholine-Sterol O-Acyltransferase