An insertion-deletion polymorphism in interleukin-1α gene associated with susceptibility to preeclampsia.
OBJECTIVE
To determine whether preeclampsia is associated with polymorphisms in the IL-1α.


METHODS
We genotyped a Chinese population (212 women with preeclampsia and 203 controls) for the polymorphism of the interleukin-1α gene (3'-untranslated region). Clinical data were collected from medical records.


RESULTS
Significantly reduced preeclampsia risk was found to be associated with both I allele (p < 0.001, OR = 0.487, CI = 0.360-0.658) and I/I genotype (p < 0.01, OR = 0.26, CI = 0.13-0.55) of the rs3783553 polymorphisms.


CONCLUSIONS
The "TTCA" insertion allele of rs3783553 contributes to reduce the individual's susceptibility for preeclampsia, which implies that the insertion allele is a protective factor for the preeclampsia development.
Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , PR China .
Peng
P
Chen
Bin
B
Zhou
Kui
K
Zhang
Zhu
Z
Zhang
Yaping
Y
Song
Yan
Y
Pu
Yan
Y
Yang
Yanyan
Y
Zhang
Rong
R
Zhou
Tao
T
Wang
Lin
L
Zhang
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D053582:Interleukin-1alpha / Q000235:genetics*; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
D053582:Interleukin-1alpha
IL-α; Polymorphism; Preeclampsia; Susceptibility.