Novel inhibitor of DNA ligase IV with a promising cancer therapeutic potential.
Department of Biochemistry, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462 024.
Ashwin
A
Kotnis
Rita
R
Mulherkar
D000818:Animals; D045744:Cell Line, Tumor; D059766:DNA End-Joining Repair / Q000187:drug effects; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000037:antagonists & inhibitors*; D004260:DNA Repair; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D012545:Schiff Bases / Q000009:adverse effects / Q000627:therapeutic use*
C578537:5,6-bis(benzylideneamino)-2-mercaptopyrimidin-4-ol; C000607893:LIG4 protein, human; D011743:Pyrimidines; D012545:Schiff Bases; D011088:DNA Ligases; D000072481:DNA Ligase ATP