[Bacteriology in acute exacerbation in patients hospitalized frequently for acute exacerbation of chronic obstructive pulmonary disease].
OBJECTIVE
To analyze the distribution of pathogens and bacterial drug resistance for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients hospitalized frequently for AECOPD versus those with infrequent admissions.


METHODS
A total of 172 patients admitted into Peking University Third Hospital for AECOPD from January 2007 to December 2008 were recruited. According to the frequency of AECOPD-related hospitalization during the previous year, they were divided into two groups of frequently hospitalized ( ≥ 2 hospitalizations due to AECOPD during the previous year) and infrequently hospitalized (<2 hospitalizations due to AECOPD during the previous year). The distribution and drug resistance of pathogenic bacteria were compared between two groups.


RESULTS
At the time of acute exacerbation, the frequently hospitalized patients had significantly higher rates of non-fermentative gram-negative bacteria (18.8% (9/48) vs 4.8% (6/124), χ² = 6.756, P = 0.009), enterobacteriaceae (18.8% (9/48) vs 7.3% (9/124), χ² = 4.877, P = 0.027) versus those infrequently hospitalized ones. The frequently hospitalized patients had more multidrug resistant bacteria isolated from sputum versus those infrequently hospitalized ones (25.0% (12/48) than 8.1% (10/124), χ² = 8.898, P = 0.003).


CONCLUSIONS
The distribution and drug resistance of pathogenic bacteria are associated with the frequency of AECOPD-related hospitalization during the previous year.
Department of Emergency Medicine, Peking University Third Hospital, Beijing 100191, China.
Zhiguo
Z
Guo
Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China. Email: doudou_1977@163.com.
Chun
C
Chang
Yahong
Y
Chen
Yaan
Y
Zheng
Wanzhen
W
Yao
D000368:Aged; D000369:Aged, 80 and over; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007297:Inpatients; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008297:Male; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D029424:Pulmonary Disease, Chronic Obstructive / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification