MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN.
It is well established that the interaction between cancer cells and microenvironment has a critical role in tumor development, but the roles of miRNAs in this interaction are rarely known. Here, we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer, the expression level of miR-106b is associated with poor prognosis of patients, and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN. Taken together, these data suggest that miR-106b might be a novel candidate target for the treatment of gastric cancer.
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: surgeonyts@163.com.
Ting-Song
TS
Yang
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: shuaitiger@163.com.
Xiao-Hu
XH
Yang
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: beautycici@163.com.
Xi
X
Chen
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: wxd19831208@163.com.
Xu-Dong
XD
Wang
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: surgeonhuajie@hotmail.com.
Jie
J
Hua
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: surgeonytszdl@hotmail.com.
Dong-Lei
DL
Zhou
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: surgeonzhoubo@163.com.
Bo
B
Zhou
Department of General Surgery, Tenth Peoples' Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: songzhenshun@hotmail.com.
Zhen-Shun
ZS
Song
D020413:3' Untranslated Regions / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D055785:Gene Knockdown Techniques; D018390:Gene Targeting; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D059016:Tumor Microenvironment / Q000235:genetics; D015854:Up-Regulation
D020413:3' Untranslated Regions; C542541:MIRN106 microRNA, human; D035683:MicroRNAs; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
Cancer associated fibroblasts; Gastric cancer; Protein tyrosine phosphatase and tensin homologue; microRNA