[A 55-year-old woman with cough, fever, swelling of joints, and exanthema after a trip to Ecuador].
A 55-year-old woman presented 18 months after a trip to Ecuador with night sweat, malaise, and an unclear lesion of the lung. Computed tomography of the lung showed a nodular lesion of 14 mm. Antibodies against Histoplasma capsulatum were detected in the complement fixation text (CFT) and IgG western blot. Re-examination of a formalin fixed paraffin embedded (FFPE) lung-biopsy revealed yeasts after silver staining, compatible with H. capsulatum , which was verified by extraction and amplification of DNA from FFPE. After therapy with itraconazole 400 mg/day, the patient showed an uneventful clinical recovery without regression of the lung lesion. The serological follow-up examination after 17 months showed CFT without pathological findings.
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland, mueller-stoever@med.uni-duesseldorf.de.
I
I
Müller-Stöver
K
K
Tintelnot
J
J
Richter
D
D
Häussinger
D000935:Antifungal Agents / Q000627:therapeutic use; D001168:Arthritis / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D003168:Complement Fixation Tests; D003371:Cough / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control; D004484:Ecuador; D005076:Exanthema / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008875:Middle Aged; D014195:Travel
D000935:Antifungal Agents; D017964:Itraconazole