Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.
In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with different amount of idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases and skin oxidative damages. The differential scanning calorimetry (DSC) was employed to evaluate the effects of the different emulsifiers and the different amounts of drug loaded on the thermotropic behavior of SLN and to investigate how the drug was arranged into these nanoparticles. The IDE seemed to be located into different regions of the SLN depending on its concentration and on the surfactant used. The results of this study suggest that the calorimetric studies performed on SLN could provide valuable information to optimize SLN design and drug release from these carriers.
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania95125, Italy.
Maria Grazia
MG
Sarpietro
Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Campus Universitario "S. Venuta"', Viale S. Venuta, Germaneto (CZ) 88100, Italy.
Maria Lorena
ML
Accolla
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania95125, Italy.
Giovanni
G
Puglisi
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania95125, Italy.
Francesco
F
Castelli
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania95125, Italy. Electronic address: lmontene@unict.it.
Lucia
L
Montenegro
D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D004355:Drug Stability; D004987:Ethers; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010168:Palmitates / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D044366:Transition Temperature; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry
D000975:Antioxidants; D004337:Drug Carriers; D004987:Ethers; D010168:Palmitates; D013501:Surface-Active Agents; D014451:Ubiquinone; D011092:Polyethylene Glycols; C006957:cetyl palmitate; C036619:idebenone
Differential scanning calorimetry; Idebenone; Solid lipid nanoparticles; Surfactants