Photoassisted one-step aerosol fabrication of zwitterionic chitosan nanoparticles.
Zwitterionic chitosan nanoparticles (ZCNPs) were conveniently obtained by a one-step aerosol method, and their potential for the production of biocompatible materials was investigated. A low-molecular-weight chitosan was conjugated with succinic anhydride to produce zwitterionic chitosan (ZC). Collison-atomized ZC droplets were simultaneously UV-irradiated and dried in a tube furnace in a one-step aerosol process to produce particles. The observed cytotoxicities of ZCNPs (85 ± 3.9% cell viability) were similar to unmodified chitosan nanoparticles (CNPs, 88 ± 6.6%) and UV-irradiated ZCNPs (83 ± 3.3%). The aerosol process described in this work allowed facile production and modification of CNPs, which could then be employed for biomedical purposes.
Department of Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Jeong Hoon
JH
Byeon
Aditya
A
Kulkarni
Hee-Kwon
HK
Kim
David H
DH
Thompson
Jeffrey T
JT
Roberts
D000336:Aerosols / Q000737:chemistry* / Q000528:radiation effects*; D048271:Chitosan / Q000737:chemistry* / Q000528:radiation effects*; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects*
D000336:Aerosols; D048271:Chitosan