The role of ovarian suspension in endometriosis surgery: a randomized controlled trial.
OBJECTIVE
A very high percentage of patients with severe pelvic endometriosis develop adhesions after laparoscopic surgery. The objective of this trial was to evaluate the role of ovarian suspension performed during surgery for severe endometriosis on ovarian adhesions and postoperative pelvic pain.


METHODS
A randomized controlled trial (Canadian Task Force classification I).


METHODS
The tertiary care University Hospital of Bologna, Bologna, Italy.


METHODS
Eighty patients with ovarian and posterior deep infiltrating endometriosis were included in the study.


METHODS
Patients underwent laparoscopic surgery for endometriosis and were randomized sequentially into 2 groups: transient ovarian suspension was performed in the treatment group (n = 40), whereas in the control group (n = 40) ovaries were left free in the pelvis. Symptom intensity (dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, and dysuria) were ranked using a visual analog scale. Postsurgical ovarian adhesions were evaluated using transvaginal ultrasonographic scans performed by an ultrasound operator who was blinded to the details of the operative procedure and women's randomization allocation. Complications, lesion localization, endometrioma diameter, and surgery time were recorded.


RESULTS
At follow-up, a significantly lower rate of ultrasound-detectable ovarian adhesions with the uterus and the bowel was observed in the treatment group, respectively (46.7% vs 77.3%, p = .003 and 26.7% vs 68.2%, p < .0005). Patients in the control group showed a higher percentage of fixed ovaries with moderate and severe adhesions than the treatment group, respectively (56.8% vs 28.9%, p = .003 and 20.5% vs 8.9%, p = .110). No differences between the 2 groups were found regarding complications and pelvic pain.


CONCLUSIONS
Ovarian suspension seems to be an additional effective surgical procedure associated with an increased ovarian mobility in women treated for severe endometriosis. Moreover, it is feasible, safe, simple, and fast. Hence, it should be routinely used during laparoscopic surgery for endometriosis.
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Renato
R
Seracchioli
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. Electronic address: nadine.didonato@gmail.com.
Nadine
N
Di Donato
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Valentina
V
Bertoldo
Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy.
Antonio
A
La Marca
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Claudia
C
Vicenzi
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Letizia
L
Zannoni
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Gioia
G
Villa
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Giorgia
G
Monti
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Deborah
D
Leonardi
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Giulia
G
Giovanardi
Department of Obstetrics and Gynecology, Gynecology and Reproductive Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Stefano
S
Venturoli
Minimally Invasive Gynecological Surgery Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Giulia
G
Montanari
D000291:Adnexal Diseases / Q000601:surgery*; D000328:Adult; D004412:Dysmenorrhea / Q000209:etiology; D004414:Dyspareunia / Q000209:etiology; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D006801:Humans; D007558:Italy; D010535:Laparoscopy / Q000009:adverse effects; D008875:Middle Aged; D010049:Ovarian Diseases / Q000517:prevention & control / Q000601:surgery*; D010053:Ovary / Q000473:pathology / Q000601:surgery*; D010147:Pain Measurement; D017699:Pelvic Pain / Q000209:etiology; D010388:Pelvis / Q000473:pathology / Q000601:surgery; D000267:Tissue Adhesions / Q000601:surgery
Adhesions; Endometriosis; Laparoscopy; Ovarian suspension; Pelvic pain; Ultrasound