Influence of an antidiabetic drug on biomechanical and histological parameters around implants in type 2 diabetic rats.
OBJECTIVE
Type 2 diabetes mellitus (DM) has a deleterious effect on dental implant integration into alveolar bone, thought to arise from impaired osteoblast function and consequent reduced bone turnover. However, whether controlling blood glucose with antidiabetic drugs is sufficient to improve implant integration is unclear. This study was designed to evaluate implant integration using diabetic rats with/without an antidiabetic drug.


METHODS
Titanium screws were surgically implanted in each tibia of 20 Goto-Kakizaki (GK) rats and 5 nondiabetic control rats. After 3 or 9 weeks, osseointegration was determined by testing the removal torque required to displace the screw and by histological analysis of various parameters of bone formation.


RESULTS
Removal torque was significantly higher in the nondiabetic control group than in GK rats, irrespective of whether the GK rats had received voglibose. Histology revealed that single-labeled surface area was still high in the GK rats at 9 weeks but had peaked and diminished in control rats. Bone-implant contact area was reduced in GK rats.


CONCLUSIONS
Despite controlling blood glucose, voglibose was unable to reverse the bone metabolic effects of DM.
*Graduate Student, Department of Oral Maxillofacial Prosthodontics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. †Assistant Professor, Department of Denture Prosthodontic Restoration, Kagoshima University Medical and Dental Hospital, Kagoshima, Japan. ‡Research Associate, Department of Oral Maxillofacial Prosthodontics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. §Associate Professor, Department of Oral Maxillofacial Prosthodontics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. ‖Visiting Scientist, Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Chikoto
C
Hashiguchi
Shin-ichiro
S
Kawamoto
Takayuki
T
Kasai
Yasuhiro
Y
Nishi
Eiichi
E
Nagaoka
D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D015921:Dental Implants / Q000009:adverse effects*; D003799:Dental Stress Analysis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004195:Disease Models, Animal; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008815:Mice, Inbred Strains; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D015921:Dental Implants; D007004:Hypoglycemic Agents; D007294:Inositol; C102817:voglibose