Five new terpenoids from the rhizomes of Isodon adenantha.
Five new terpenoids including 2 labdane diterpenoids (1 and 2), 2 ent-kaurane diterpenoids (3 and 4), and a new oleanane triterpenoid (5), along with 13 known compounds (6-18), were isolated from the ethyl acetate fraction of 70% acetone extract of the rhizomes of Isodonadenantha. Their structures were elucidated based on the analyses of spectroscopic data and comparison of their physicochemical properties. The structure of 1 was further confirmed by single-crystal X-ray diffraction. Cytotoxicity and antibacterial activities of the samples were measured by MTT method and the filter paper disk agar diffusion method. But none of them showed significant activities.
a College of Pharmacy and Chemistry, Institute of Materia Medica, Dali University , Dali 671000 , China.
Xing-Li
XL
Zhou
Chao-Jiang
CJ
Xiao
La-Bin
LB
Wu
Bo
B
Huang
Xiang
X
Dong
Bei
B
Jiang
D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification; D027343:Rhizome / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
D045786:Diterpenes, Kaurane; D013729:Terpenes; D009828:Oleanolic Acid
Isodonadenantha; antibacterial activity; chemical constituents; cytotoxicity; terpenoids