Electrospun titania sol-gel-based ceramic composite nanofibers for online micro- solid-phase extraction with high-performance liquid chromatography.
Titanium(IV) tetraisopropoxide was employed as a metal oxide sol-gel precursor to prepare ceramic composite nanofibers by the electrospinning system. To facilitate this process and obtain the desired nanofibers with higher aspect ratios and surface area, poly(vinylpyrrolidone) was added to the sol of titania. Four ceramic nanofibers sheets based on titania were prepared while each sheet contained different transition metals such as Fe-Mn, Fe-Ni, Fe-Co, and Fe-Mn-Co-Ni. The scanning electron microscope images showed good homogeneity for all the prepared ceramic composites with a diameter range of 100-250 nm. The sorption efficiency was investigated by a micro-solid-phase extraction setup in online combination with high-performance liquid chromatography for the determination of naproxen and clobetasol. All the prepared composites exhibited comparable efficiencies for the desired analytes and the type of metal showed insignificant effect. For the selected composite with Fe-Mn, the linearity of the analytes was in the range of 1-1000 μg/L and the limit of detection values were found to be 2 and 0.3 μg/L for naproxen and clobetasol, respectively. The developed method was extended to the analysis of urine and blood plasma samples and acceptable relative standard deviations were obtained at two concentration levels.
Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Habib
H
Bagheri
Hamed
H
Piri-Moghadam
Soroush
S
Rastegar
Navid
N
Taheri
D000893:Anti-Inflammatory Agents / Q000097:blood / Q000302:isolation & purification* / Q000652:urine; D001331:Automation / Q000295:instrumentation / Q000379:methods*; D002516:Ceramics / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002990:Clobetasol / Q000097:blood / Q000302:isolation & purification* / Q000652:urine; D006801:Humans; D008297:Male; D057139:Nanofibers / Q000737:chemistry; D009288:Naproxen / Q000097:blood / Q000302:isolation & purification / Q000652:urine; D052617:Solid Phase Microextraction / Q000295:instrumentation / Q000379:methods*; D014025:Titanium / Q000737:chemistry
D000893:Anti-Inflammatory Agents; C009495:titanium dioxide; D009288:Naproxen; D002990:Clobetasol; D014025:Titanium
Ceramic composites; Electrospinning; High-performance liquid chromatography; Metal oxide nanofibers; Micro-solid-phase extraction