Anticoagulant motifs of marine sulfated glycans.
Sulfated polysaccharides, like the glycosaminoglycan (GAG) heparin, are known to exhibit anticoagulant properties when certain structural features are present. The structural requirement for this action is well-established for heparin, in which a pentasaccharide motif plays a key role for keeping the high-affinity interaction to antithrombin. Over the last years of this glycomic era, several novel anticoagulant sulfated glycans have been described. Those from marine sources have been awakening special attention mainly because of their impressive anticoagulant effects together with structural uniqueness. The commonest of these glycans are the sulfated fucans (SFs), the sulfated galactans (SGs), and the marine invertebrate GAGs like the fucosylated chondroitin sulfate and ascidian dermatan sulfate. Since these marine sulfated glycans do not bear within their polymeric chains the specific pentasaccharide motif of heparin, other structural features must be necessary to trigger the anticoagulant effect. The objective of this report is to present the anticoagulant motifs of the marine SFs, SGs and GAGs.
Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 255, HUCFF 4A01, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil, pominvh@bioqmed.ufrj.br.
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D000818:Animals; D000925:Anticoagulants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry* / Q000378:metabolism; D002240:Carbohydrate Sequence; D005685:Galactans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007448:Invertebrates / Q000737:chemistry* / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013463:Sulfuric Acid Esters / Q000737:chemistry* / Q000494:pharmacology
D000925:Anticoagulants; D005685:Galactans; D011134:Polysaccharides; D013463:Sulfuric Acid Esters; C046510:galactan polysulfate; C007789:fucoidan