G protein β3 subunit polymorphism and long-term prognosis of functional dyspepsia.
OBJECTIVE
A link between G protein β3 (GNB3) polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role of GNB3 polymorphism in the long-term prognosis of FD in Koreans.


METHODS
FD patients and normal healthy controls were recruited from patients who visited our center between December 2006 and June 2007. All of the subjects completed Rome III questionnaires before undergoing upper gastrointestinal endoscopy and colonoscopy. Genomic DNA was extracted for GNB3 genotyping. After 5 years, the subjects were reevaluated using the same questionnaires.


RESULTS
GNB3 825T carrier status was significantly related to FD in Koreans (p=0.04). After 5 years, 61.0% of the initial FD patients and 12.2% of the initial normal subjects were diagnosed with FD (odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to 31.1; p<0.001). Regardless of the GNB3 genotype (p=0.798), female sex was strongly correlated with FD after 5 years (OR, 3.3; 95% CI, 1.2 to 9.1; p=0.017).


CONCLUSIONS
The T allele of GNB3 is linked to FD in Koreans but does not predict long-term prognosis. Female sex is related to a higher prevalence of FD after 5 years.
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Hyun Ah
HA
Chung
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Sun Young
SY
Lee
Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
Heon Jeong
HJ
Lee
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Jeong Hwan
JH
Kim
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
In Kyung
IK
Sung
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Chan Sup
CS
Shim
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Choon Jo
CJ
Jin
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Hyung Seok
HS
Park
D016022:Case-Control Studies; D004415:Dyspepsia / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011446:Prospective Studies
C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins
Functional dyspepsia; G protein β3; Polymorphism; Prognosis; Rome III