Chromatin remodeling: from transcription to cancer.
In this short review article, I have tried to trace the path that led my laboratory from the early studies of the structure of papova minichromosomes and transcription control to the investigation of chromatin remodeling complexes of the SWI/SNF family. I discuss briefly the genetic and biochemical studies that lead to the discovery of the SWI/SNF complex in yeast and drosophila and summarize some of the studies on the developmental role of the murine complex. The discovery of the tumor suppressor function of the SNF5/INI1/SMARCB1 gene in humans and the identification of frequent mutations in other subunits of this complex in different human tumors opened a fascinating field of research on this epigenetic regulator. The hope is to better understand tumor development and to develop novel treatments.
Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France. Electronic address: yaniv@pasteur.fr.
Moshe
M
Yaniv
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D004331:Drosophila melanogaster; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D051379:Mice; D018335:Rhabdoid Tumor / Q000235:genetics*; D000071796:SMARCB1 Protein; D012441:Saccharomyces cerevisiae / Q000254:growth & development; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
SWI/SNF; cell cycle; development; differentiation; tumor suppressor