Association of untreated metabolic syndrome with moderate to severe periodontitis in Thai population.
BACKGROUND
Metabolic syndrome (MetS) correlates with systemic inflammation. A relation of MetS to periodontitis has been reported. This study aims to evaluate whether periodontitis is associated with untreated MetS, plasma adiponectin, and leptin among Thai people.


METHODS
One hundred twenty-five participants (aged 35 to 76 years) were recruited. Demographic and biologic data, bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) of all teeth were examined. Plasma adiponectin and leptin levels were measured.


RESULTS
Forty-four participants (35.2%) were healthy, and 81 (64.8%) had MetS. All periodontal conditions (BOP, PD, and CAL) were significantly worse in patients with MetS than healthy participants. After adjustment for confounders, MetS was strongly associated with severe periodontitis (odds ratio [OR] = 3.60, 95% confidence interval [CI]: 1.34 to 9.65). MetS with four to five components had a higher association with periodontitis than did MetS with three components (OR = 5.49, 95% CI: 1.75 to 17.19), whereas each separate component had no association with periodontitis, except for high diastolic blood pressure. Periodontitis was also associated with age (OR = 1.08, 95% CI: 1.01 to 1.14) and education (OR = 3.76, 95% CI: 1.05 to 13.40). The risk of MetS was predicted by body mass index and plasma adiponectin (OR = 1.90, 95% CI: 1.24 to 2.92 and OR = 0.93, 95% CI: 0.88 to 0.98, respectively).


CONCLUSIONS
There may be a relationship between untreated MetS and periodontitis in Thai people. Periodontal diagnosis should be regularly conducted in patients with MetS.
Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Supanee
S
Thanakun
Hisashi
H
Watanabe
Sroisiri
S
Thaweboon
Yuichi
Y
Izumi
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D048909:Diabetes Complications; D004522:Educational Status; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D015228:Hypertriglyceridemia / Q000150:complications; D052456:Hypoalphalipoproteinemias / Q000150:complications; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000150:complications; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000150:complications; D010518:Periodontitis / Q000150:complications*; D013785:Thailand; D055105:Waist Circumference
C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin
Adiponectin; Asian Continental Ancestry Group; leptin; metabolic syndrome X; periodontitis; waist circumference