Clinical outcomes and evaluation of the quality of life of living donors for pediatric liver transplantation: a single-center analysis of 100 donors.
There are few reports about the quality of life (QOL) and morbidities of pediatric living donor liver transplantation (LDLT) donors. We evaluated the potential morbidities and identified the predictive factors regarding the QOL of living donors after pediatric LDLT. This cross-sectional study was a single-center analysis of 100 donors for pediatric LDLT. The severity of morbidities was assessed with the Clavien classification, the QOL was investigated with the short form-36 (SF-36), and the decision-making process regarding donation was analyzed with questionnaires. The median follow-up period was 3.8 years (range, 2.2-6.0 years). A total of 13% of the donors developed postoperative complications of Clavien grades I (7%), II (3%), and IIIA (3%). There was no grade IV morbidity or mortality. Eighty-one donors responded to the questionnaire and SF-36. The analysis of the questionnaires revealed that the donors had difficulty in the decision-making process, and suggested that it may be necessary to administer multistep informed consent. We identified unique predictive risk factors for lower SF-36 scores in the donors, which were the time to donation (more than 4 weeks) and the predonation self-oriented perception. The donors who have risk factors require enhanced pre- and post-donation psychological care.
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan. Electronic address: fukuda-a@ncchd.go.jp.
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Fukuda
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Sakamoto
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Shigeta
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Uchida
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Hamano
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Sasaki
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Kanazawa
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Loh
Department of Health Policy, National Research Institute for Child Health and Development, Tokyo, Japan.
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Kakee
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Nakazawa
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
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Kasahara
D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D011788:Quality of Life; D016896:Treatment Outcome