Reining in radiation injury: HIF2α in the gut.
Deletion of prolyl hydroxylase domain proteins or overexpression of hypoxia-inducible factor 2α (HIF2α) in the gastrointestinal epithelium improves survival of mice after abdominal irradiation (Taniguchi et al., this issue).
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Chang-Lung
CL
Lee
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Everett J
EJ
Moding
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. david.kirsch@duke.edu.
David G
DG
Kirsch
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D011832:Radiation Injuries / Q000188:drug therapy*; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1