Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios.
This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia. A total of 200 family trios consisting of fathers, mothers, and affected offspring with schizophrenia were recruited as our participants. Four tag SNPs on MBD1 (rs125555, rs140689, rs140687, and rs140686), three tag SNPs on MBD2 (rs3876254, rs7614, and rs1145317), and three tag SNPs on MBD3 (rs7252741, rs4807934, and rs4807122) genes were tested using the PCR-based ligase detection reaction (PCR-LDR). The transmission disequilibrium test showed that rs1145317 on the MBD2 gene was significantly overtransmitted from parents to schizophrenic offspring (P=0.026). The haplotype-based haplotype relative risk test revealed that the haplotype rs7614-rs1145317 (A-G) was associated with schizophrenia (P=0.029). Our finding suggests that the MBD2 gene may be a susceptibility gene for schizophrenia.
aResearch Center for Genomic Medicine bDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University cChangchun Mental Health Hospital, Changchun dCentral Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Bing
B
Xie
Yaqin
Y
Yu
Xiangfei
X
Meng
Qiong
Q
Yu
Jieping
J
Shi
Hong
H
Sang
Changgui
C
Kou
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D005819:Genetic Markers; C066141:MBD1 protein, human; C489325:MBD2 protein, human; C115369:MBD3 protein, human; D014157:Transcription Factors