Triphase interface synthesis of plasmonic gold bellflowers as near-infrared light mediated acoustic and thermal theranostics.
We present a novel gold bellflower (GBF) platform with multiple-branched petals, prepared by a liquid-liquid-gas triphase interface system, for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Upon near-infrared (NIR) laser irradiation, the GBFs, with strong NIR absorption, showed very strong PA response and an ultrahigh photothermal conversion efficiency (η, ∼74%) among the reported photothermal conversion agents. The excellent performance in PAI and PTT is mainly attributed to the unique features of the GBFs: (i) multiple-branched petals with an enhanced local electromagnetic field, (ii) long narrow gaps between adjacent petals that induce a strong plasmonic coupling effect, and (iii) a bell-shaped nanostructure that can effectively amplify the acoustic signals during the acoustic propagation. Besides the notable PTT and an excellent PAI effect, the NIR-absorbing GBFs may also find applications in NIR light-triggered drug delivery, catalysis, surface enhanced Raman scattering, stealth, antireflection, IR sensors, telecommunications, and the like.
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health , Bethesda, Maryland 20892, United States.
Peng
P
Huang
Pengfei
P
Rong
Jing
J
Lin
Wanwan
W
Li
Xuefeng
X
Yan
Molly Gu
MG
Zhang
Liming
L
Nie
Gang
G
Niu
Jie
J
Lu
Wei
W
Wang
Xiaoyuan
X
Chen
D000818:Animals; D016466:CHO Cells; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003412:Cricetulus; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006046:Gold / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000628:therapy; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D008819:Mice, Nude; D010316:Particle Size; D044367:Phase Transition; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D019265:Spectroscopy, Near-Infrared; D020349:Surface Plasmon Resonance; D013499:Surface Properties
D006046:Gold