Surface-initiated polymerization within mesoporous silica spheres for the modular design of charge-neutral polymer particles.
We report a templating approach for the preparation of functional polymer replica particles via surface-initiated polymerization in mesoporous silica templates. Subsequent removal of the template resulted in discrete polymer particles. Furthermore, redox-responsive replica particles could be engineered to disassemble in a reducing environment. Particles, made of poly(methacryloyloxyethyl phosphorylcholine) (PMPC) or poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), exhibited very low association to human cancer cells (below 5%), which renders the reported charge-neutral polymer particles a modular and versatile class of highly functional carriers with potential applications in drug delivery.
Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville 3010, Australia.
Markus
M
Müllner
Jiwei
J
Cui
Ka Fung
KF
Noi
Sylvia T
ST
Gunawan
Frank
F
Caruso
D016503:Drug Delivery Systems; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D010084:Oxidation-Reduction; D010316:Particle Size; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); C524499:polyethylene glycol methacrylate; D014867:Water; D010767:Phosphorylcholine; D011092:Polyethylene Glycols; D012822:Silicon Dioxide