The wind god promotes lung cancer.
In this issue of Cancer Cell, Li and colleagues demonstrate that the hematopoietic transcription factor Aiolos (named after the Wind God of Greek mythology) confers anoikis resistance in lung tumor cells through repression of cell adhesion-related genes including the mechanosensor p66Shc.
Department of Biochemistry and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA. Electronic address: sfrisch@hsc.wvu.edu.
Steven M
SM
Frisch
Department of Biochemistry and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
Michael D
MD
Schaller
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D051740:Ikaros Transcription Factor / Q000378:metabolism*; D008175:Lung Neoplasms / Q000235:genetics*; D055765:Shc Signaling Adaptor Proteins / Q000235:genetics*; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
C106285:IKZF3 protein, human; C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D051740:Ikaros Transcription Factor