Genomics in primary care practice.
This article discusses the clinical utility of genomic information for personalized preventive care of a healthy adult. Family health history is currently the most applicable genomic predictor for common, multifactorial diseases, and can also show patterns that suggest an inherited high susceptibility to a particular form of cancer or other disease. Both bloodline ancestry and shared environmental factors are important predictors for many disease states. DNA and family history analyses give information that is probabilistic, not deterministic. Therefore, family history can highlight behavioral, social, or cultural risk factors that can be modified to prevent diseases.
Internal Medicine, Center for Personalized Healthcare (Cleveland Clinic), 9500 Euclid Avenue, NE5-203, Cleveland, OH 44195, USA. Electronic address: tengk@ccf.org.
Kathryn
K
Teng
Departments of Family Medicine, Oncology, and Reproductive Biology, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5036, USA.
Louise S
LS
Acheson
D005006:Ethnicity / Q000235:genetics; D005192:Family Health; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D011320:Primary Health Care / Q000458:organization & administration*; D044469:Racial Groups / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors
Ancestry; Family health history; Genomic; Preventive care; Primary care; Value