Transition-metal-free oxidative carboazidation of acrylamides via cascade C-N and C-C bond-forming reactions.
A novel transition-metal-free oxidative carboazidation of acrylamides using inexpensive NaN3 and K2S2O8 was achieved, which not only provided an efficient method to prepare various N3-substituted oxindoles, but also represented a novel strategy for C-N and C-C bond formation via a free-radical cascade process. This transformation exhibits excellent functional group tolerance, affording the desired oxindoles in good to excellent yields.
Department of Chemistry, Tongji University, Shanghai 200092, P. R. China.
Jun
J
Qiu
Ronghua
R
Zhang
D000178:Acrylamides / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D028561:Transition Elements / Q000737:chemistry*
D000178:Acrylamides; D001386:Azides; D012997:Solvents; D028561:Transition Elements