Corticolimbic connectivity as a possible biomarker for bipolar disorder.
Bipolar disorder is a severe, disabling and life-threatening illness, which affects nearly 2% of the general population. The identification of reliable and objective biomarkers may aid early diagnosis and optimize treatment efficacy. Through a careful overview of the neuroimaging studies which investigated the structural, functional, and effective connectivity in bipolar disorder, we explored the role of a disconnected cortico-limbic circuitry in the development and maintenance of the disorder. This review offers perspectives and suggestions for future research, in order to propose the corticolimbic disconnection as a neurobiological underpinning and biomarker for bipolar psychopathology.
Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, San Raffaele Turro, Via Stamira d'Ancona 20, Milano, Italy.
Benedetta
B
Vai
Irene
I
Bollettini
Francesco
F
Benedetti
D015415:Biomarkers; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000503:physiopathology*; D009415:Nerve Net / Q000503:physiopathology*; D059906:Neuroimaging
D015415:Biomarkers
biomarker; bipolar disorder; connectivity; corticolimbic circuitry; development