Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice.
Converging evidence from both preclinical and clinical studies suggests atrial natriuretic peptide (ANP) as a potential target for treatment of alcohol withdrawal and dependence. Since ANP tightly interacts with hypothalamic-pituitary-adrenocortical (HPA) axis activity, especially the modulation of stress-related anxiety during alcohol withdrawal might mediate these effects. We have now evaluated the anxiolytic activity of intraperitoneal ANP application during alcohol withdrawal in alcohol-habituated mice (C57/Bl6J). Anxiety related behaviour was attenuated during ethanol withdrawal following application of ANP (60 μg/kg) vs. saline. Our results support that anxiolytic effects of ANP mediate ANP-related gene effects with clinical data on withdrawal symptomatology.
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
C
C
von der Goltz
Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany.
H
H
Jahn
Department of Psychiatry, Psychotherapy and Psychosomatics Center for Addictive Disorders, Zurich University Hospital of Psychiatry, Zurich, Switzerland.
J
J
Mutschler
Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany.
K
K
Wiedemann
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
F
F
Kiefer
D000428:Alcohol Drinking / Q000188:drug therapy; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D009320:Atrial Natriuretic Factor / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D018709:Statistics, Nonparametric; D013375:Substance Withdrawal Syndrome / Q000150:complications*
D014151:Anti-Anxiety Agents; D000431:Ethanol; D009320:Atrial Natriuretic Factor