Pharmacologic biomarkers in the development of stratified cancer medicine.
Clinical pharmacologic research plays a vital role in cancer drug development. In recent years, biomarker studies have become integral to this process, specifically the use of pharmacologic biomarkers in the development of targeted therapies and their translation to clinical practice. In this overview, we discuss the validation of pharmacodynamics (PD) biomarkers and highlight the circulating tumor DNA as a promising cancer biomarker to illustrate how PD biomarkers can be powerful tools for guiding treatment strategies. We provide insights into PD biomarker approaches for future development of novel therapies and their role in cancer medicine. See all articles in this CCR focus section, "Progress in pharmacodynamic endpoints."
Authors' Affiliations: Clinical Pharmacology Program, Office of the Clinical Director, Molecular Pharmacology Section and Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and Northern Institute for Cancer Research, Newcastle University, Newcastle, United Kingdom figgw@helix.nih.gov herbie.newell@ncl.ac.uk.
William Douglas
WD
Figg
Authors' Affiliations: Clinical Pharmacology Program, Office of the Clinical Director, Molecular Pharmacology Section and Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and Northern Institute for Cancer Research, Newcastle University, Newcastle, United Kingdom figgw@helix.nih.gov herbie.newell@ncl.ac.uk.
David R
DR
Newell
D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood / Q000235:genetics; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm