In vitro dosimetry of agglomerates.
Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposure, primarily due to differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetic profiles, and their cellular uptake was compared to a computational model of dosimetry. The approach used here paves the way for a better understanding of the impact of agglomeration on the nanoparticle-cell interaction.
Adolphe Merkle Institute, University of Fribourg, Route de l'Ancienne Papeterie, P.O. Box 209, Marly 1723, Switzerland.
V
V
Hirsch
C
C
Kinnear
L
L
Rodriguez-Lorenzo
C A
CA
Monnier
B
B
Rothen-Rutishauser
S
S
Balog
A
A
Petri-Fink
D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012542:Scattering, Radiation; D008625:Tiopronin / Q000737:chemistry
D006046:Gold; D011142:Polyvinyl Alcohol; D008625:Tiopronin