Cervical cancer detection by time-resolved spectra of blood components.
Fluorescence spectral techniques are very sensitive, and hence they are gaining importance in cancer detection. The biomarkers indicative of cancer could be identified and quantified by spectral or time domain fluorescence spectroscopy. The results of an investigation of time-resolved spectra of cellular components of blood obtained from cervical cancer patients and normal controls are given. The cancer indicative biomarker in this paper is porphyrin; it has a fluorescence decay time of 60% more in samples of cancer patients than those of normal controls. Based on such measurements, a randomized set comprising samples from cancer patients and controls (N=27 in total) could be classified with sensitivity (92%) and specificity (86%).
King Saud University, Department of Physics and Astronomy, Riyadh 11451, Kingdom of Saudi ArabiabUniversity of Madras, Department of Nuclear Physics, Chennai 600005, India.
Rudran
R
Kalaivani
King Saud University, Department of Physics and Astronomy, Riyadh 11451, Kingdom of Saudi Arabia.
Vadivel
V
Masilamani
King Saud University, Department of Physics and Astronomy, Riyadh 11451, Kingdom of Saudi Arabia.
Mohamad Saleh
MS
AlSalhi
King Saud University, Research Chair, Laser Diagnosis of Cancers, Kingdom of Saudi Arabia.
Sandhanasamy
S
Devanesan
University of Madras, National Centre for Ultrafast Processes, Taramani Campus, Chennai 600113, India.
P
P
Ramamurthy
Kidwai Memorial Institute of Oncology, Bangalore 560029, India.
Siddanna R
SR
Palled
Kidwai Memorial Institute of Oncology, Bangalore 560029, India.
K M
KM
Ganesh
D000328:Adult; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000097:blood*; D001774:Blood Chemical Analysis / Q000379:methods*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*; D011166:Porphyrins / Q000097:blood; D015203:Reproducibility of Results; D013050:Spectrometry, Fluorescence / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000175:diagnosis
D014408:Biomarkers, Tumor; D011166:Porphyrins