title: Synthesis of magnetic FexOy@silica-pillared clay (SPC) composites via a novel sol-gel route for controlled drug release and targeting.
abstract: Novel magnetic silica-pillared clay (SPC) materials with an ordered interlayered mesopore structure were synthesized via a two-step method including gallery molecular self-assembly and sol-gel magnetic functionalization, resulting in the formation of FexOy@SPC composites. Small-angle XRD, TEM and N2 adsorption-desorption isotherms results show that these composites conserved a regular layered and ordered mesoporous structure after the formation of FexOy nanoparticles. Wide-angle XRD and XPS analyses confirmed that the FexOy generated in these mesoporous silica-pillared clay hosts is mainly composed of γ-Fe2O3. Magnetic measurements reveal that these composites with different γ-Fe2O3 loading amounts possess super-paramagnetic properties at 300K, and the saturation magnetization increases with increasing Fe ratio loaded. Compared to the pure SPC, the in vitro drug release rate of the FexOy@SPC composites was enhanced due to the fact that the intensities of the SiOH bands on the pore surface of SPC decrease after the generation of FexOy. However, under an external magnetic field of 0.15T, the drug release rate of the FexOy@SPC composites decreases dramatically owing to the aggregation of the magnetic FexOy@SPC particles triggered by non-contact magnetic force. The obtained FexOy@SPC composites imply the possibility of application in magnetic drug targeting.
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou, Jiangsu Province 213164, PR China; State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: maohuihui_beijing@126.com.
authors.forename: Huihui
authors.initials: H
authors.lastname: Mao
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou, Jiangsu Province 213164, PR China.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou, Jiangsu Province 213164, PR China. Electronic address: yangjihe@cczu.edu.cn.
authors.forename: Jihe
authors.initials: J
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Baoshan
authors.initials: B
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou, Jiangsu Province 213164, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yao
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou, Jiangsu Province 213164, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Kong
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry* / Q000378:metabolism; D000077215:Clay; D004337:Drug Carriers / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D004337:Drug Carriers; D005290:Ferric Compounds; D005782:Gels; C000499:ferric oxide; D012822:Silicon Dioxide; D001241:Aspirin; D000077215:Clay
keywords: Drug release; Magnetic functionalization; Silica-pillared clay; Sol–gel