title: Peripheral neuropathy in children on stauvudine therapy.
abstract: OBJECTIVE
  To assess the prevalence of peripheral neuropathy in HIV infected children (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study.
  
  
  METHODS
  History, detailed neurological examination and nerve conduction studies were performed.
  
  
  RESULTS
  Forty children [26 boys; median age - 11.75 y, Inter quartile range (IQR): 9-16 y] were enrolled. The median duration of ART was 43 mo [IQR: 18-69 mo]. The nerve conduction studies were abnormal in four children (10 %). Symptomatic distal sensory polyneuropathy was present in two children, asymptomatic distal sensory polyneuropathy and subclinical distal sensory polyneuropathy was present in one child each.
  
  
  CONCLUSIONS
  Distal sensory polyneuropathy is a potential problem in children on stavudine based ART. Children on stavudine based ART need periodic clinical and electrophysiological screening for its early detection.
authors.affiliation: Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Sankhyan
authors.forename: Rakesh
authors.initials: R
authors.lastname: Lodha
authors.forename: Suvasini
authors.initials: S
authors.lastname: Sharma
authors.forename: P Ramesh
authors.initials: PR
authors.lastname: Menon
authors.forename: Anita
authors.initials: A
authors.lastname: Choudhary
authors.forename: Sushil K
authors.initials: SK
authors.lastname: Kabra
authors.forename: Sheffali
authors.initials: S
authors.lastname: Gulati
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D009460:Neurologic Examination / Q000379:methods; D017063:Outcome Assessment, Health Care; D010045:Outpatients / Q000706:statistics & numerical data; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control; D018119:Stavudine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D019380:Anti-HIV Agents; D018119:Stavudine