title: Isolation of IgG antibodies to Toxocara in ankylosing spondylitis patients with acute anterior uveitis.
abstract: OBJECTIVE
  Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU.
  
  
  METHODS
  Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions.
  
  
  RESULTS
  The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS.
  
  
  CONCLUSIONS
  These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
authors.affiliation: Rheumatology Department, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico.
authors.forename: Francisco-Javier
authors.initials: FJ
authors.lastname: Jiménez-Balderas
authors.affiliation: Rheumatology Department, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico.
authors.forename: Janete
authors.initials: J
authors.lastname: García-Jaimes
authors.affiliation: Ophthalmology Department, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico.
authors.forename: Rita
authors.initials: R
authors.lastname: Ríos
authors.affiliation: Rheumatology Department, Regional General Hospital 20, Mexican Institute of Social Security, Tijuana Baja California, Mexico.
authors.forename: Abraham
authors.initials: A
authors.lastname: Zonana-Nacach
authors.affiliation: National Institute of Diagnostic and Epidemiological Reference, Ministry of Health, Mexico City, Mexico.
authors.forename: Raquel
authors.initials: R
authors.lastname: Tapia-Romero
authors.affiliation: National Institute of Diagnostic and Epidemiological Reference, Ministry of Health, Mexico City, Mexico.
authors.forename: Nayeli
authors.initials: N
authors.lastname: Villanueva
authors.affiliation: Immunology Department, National School of Biological Sciences, National Politecnic Institute, Mexico City, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Méndez-Samperio
authors.affiliation: National Institute of Diagnostic and Epidemiological Reference, Ministry of Health, Mexico City, Mexico.
authors.forename: Jorge-Luis
authors.initials: JL
authors.lastname: de-la-Rosa-Arana
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D015822:Eye Infections, Parasitic / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000276:immunology / Q000469:parasitology; D017166:Toxocara canis / Q000276:immunology* / Q000302:isolation & purification; D014120:Toxocariasis / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D014606:Uveitis, Anterior / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D055815:Young Adult
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G
keywords: Ankylosing-spondylitis; Anterior-uveitis; Toxocariasis