title: A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application.
abstract: This study reports on the performance of sodium alginate (SA)/poly(vinyl alcohol) (PVA)/moxifloxacin hydrochloride (MH) nanofibrous membranes (NFM) capable of providing antibacterial agent delivery for wound-dressing applications. The aim of this work was to prepare antibacterial NFM with good permeability properties by employing PVA and SA as carriers. A group of 12% PVA/2% SA solutions blended in various ratios (8:2, 7:3, 6:4, 5:5 and 4:6, v/v) and containing 0.5, 1, 2 or 4 wt% MH were studied for electrospinning into nanoscale fibermats. The optimum ratio found to form smooth fibers with uniform fibrous features was 6:4. The drug release behavior of the electrospun, the antibacterial effects on Pseudomonas aeruginosa and Staphylococcus aureus and the animal wound dressing capabilities were also investigated. As much as 80% of the MH was released from the electrospun after 10 h of incubation at 37 °C. In addition, the NFM with 0.5 MH exhibited less activity, whereas those with higher concentrations of MH exhibited greater antibacterial effect. Furthermore, the MH-loaded electrospun accelerated the rate of wound dressing compared to other groups. The results of the in vitro and in vivo experiments suggest that MH/PVA/SA nanofibers might be an interesting bioactive wound dressing for clinical applications.
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing , P. R. China and.
authors.forename: Ruoqiu
authors.initials: R
authors.lastname: Fu
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing , P. R. China and.
authors.forename: Chenwen
authors.initials: C
authors.lastname: Li
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing , P. R. China and.
authors.forename: Caiping
authors.initials: C
authors.lastname: Yu
authors.affiliation: b College of Pharmacy, Chongqing Medical University , Chongqing , P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xie
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing , P. R. China and.
authors.forename: Sanjun
authors.initials: S
authors.lastname: Shi
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing , P. R. China and.
authors.forename: Zhuoheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: b College of Pharmacy, Chongqing Medical University , Chongqing , P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing , P. R. China and.
authors.forename: Laichun
authors.initials: L
authors.lastname: Lu
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry*; D001458:Bandages; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D000077266:Moxifloxacin; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013211:Staphylococcus aureus / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D000077266:Moxifloxacin
keywords: Biodegradable polymers; biomaterials; electrospinning; nanotechnology; wound healing