title: Regulatory role of microRNAs in ovarian function.
abstract: MicroRNAs have recently begun to be explored in ovarian cells, uncovering their influence on fundamental ovarian features like steroidogenesis, ovulation, and curpos luteum development and function. We provide a review of the current knowledge on microRNAs, specifically relating to human ovarian cell function and microRNAs' role in the ovarian physiologic process and ovulation dysfunction. Because of microRNAs' known stability in body fluids, we enlighten also their potential use in the clinical setting as novel biomarkers for ovarian function. Future research of the role of microRNAs in physiologic and dysfunctional ovulation may offer new diagnostic and treatment strategies for infertility and other ovarian disorders.
authors.affiliation: IVF Unit, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel. Electronic address: talim@hadassah.org.il.
authors.forename: Tal
authors.initials: T
authors.lastname: Imbar
authors.affiliation: The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Eisenberg
mesh_terms: D000818:Animals; D054885:Cumulus Cells / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D005260:Female; D005298:Fertility; D005786:Gene Expression Regulation; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D008184:Luteal Cells / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism; D010049:Ovarian Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D010053:Ovary / Q000378:metabolism* / Q000503:physiopathology; D010060:Ovulation / Q000235:genetics; D011247:Pregnancy; D043244:Ribonuclease III / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases
keywords: PCOS; POF; corpus luteum; microRNA; ovulation; serum biomarkers