title: Primary lung cancer in lung transplant recipients.
abstract: Risk factors for lung cancer in lung transplant recipients are a history of smoking and immunosuppression, to which adds increasing use of lungs from donors with a smoking history. The three typical presentations are incidental diagnosis on the explanted lung, concerning less than 2%; lung cancer developing on the lung graft, accounting for less than 1%; and incidence of lung cancer on the native lung, estimated at 9%. Treatment along available guidelines may be hampered by decreased lung function owing to chronic rejection or adverse effects of immunosuppression. Prognosis is comparable to a general population in resected stage I cancer and is less favorable in advanced stages.
authors.affiliation: Groupe de Transplantation Pulmonaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; EA7293, Stress Vasculaire et Tissulaire en Transplantation, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France.
authors.forename: Anne B M
authors.initials: AB
authors.lastname: Olland
authors.affiliation: Groupe de Transplantation Pulmonaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Falcoz
authors.affiliation: Groupe de Transplantation Pulmonaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
authors.forename: Nicola
authors.initials: N
authors.lastname: Santelmo
authors.affiliation: Groupe de Transplantation Pulmonaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; EA7293, Stress Vasculaire et Tissulaire en Transplantation, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Kessler
authors.affiliation: Groupe de Transplantation Pulmonaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; EA7293, Stress Vasculaire et Tissulaire en Transplantation, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France. Electronic address: gilbert.massard@chru-strasbourg.fr.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Massard
mesh_terms: D002283:Carcinoma, Bronchogenic / Q000209:etiology*; D006084:Graft Rejection / Q000150:complications* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors