title: Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages.
abstract: Human papillomavirus (HPV) genotype 52 is commonly found in Asian cases of cervical cancer but is rare elsewhere. Analysis of 611 isolates collected worldwide revealed a remarkable geographical distribution, with lineage B predominating in Asia (89.0% vs 0%-5.5%; P(corrected) < .001), whereas lineage A predominated in Africa, the Americas, and Europe. We propose that the name "Asian lineage" be used to denote lineage B, to signify this feature. Preliminary analysis suggested a higher disease risk for lineage B, although ethnogeographical confounders could not be excluded. Further studies are warranted to verify whether the reported high attribution of disease to HPV52 in Asia is due to the high prevalence of lineage B.
authors.affiliation: Department of Microbiology.
authors.forename: Chuqing
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Park
authors.affiliation: Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Grce
authors.affiliation: HPV Research Group, Cancer and Genetics Research Institute, School of Medicine, Cardiff University, United Kingdom.
authors.forename: Samantha
authors.initials: S
authors.lastname: Hibbitts
authors.affiliation: Department of Medicine.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Palefsky
authors.affiliation: Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Konno
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences Helen Diller Family Comprehensive Cancer Center.
authors.forename: Karen K
authors.initials: KK
authors.lastname: Smith-McCune
authors.affiliation: Sezione di Microbiologia, Dipartimento di Scienze per la Promozione della Salute, Azienda Ospedaliera Universitaria Policlinico P. Giaccone, Palermo.
authors.forename: Lucia
authors.initials: L
authors.lastname: Giovannelli
authors.affiliation: Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
authors.forename: Tang-Yuan
authors.initials: TY
authors.lastname: Chu
authors.affiliation: Servicio Virus Oncogénicos, Departamento Virología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Carlos G. Malbrán, Buenos Aires, Argentina.
authors.forename: María Alejandra
authors.initials: MA
authors.lastname: Picconi
authors.affiliation: Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, CMN Siglo XXI, México DF.
authors.forename: Patricia
authors.initials: P
authors.lastname: Piña-Sánchez
authors.affiliation: Department of Physiology, Faculty of Medicine, Khon Kaen University, Thailand.
authors.forename: Wannapa
authors.initials: W
authors.lastname: Settheetham-Ishida
authors.affiliation: Département de Microbiologie et Infectiologie, Centre Hospitalier de l'Université de Montréal, Canada.
authors.forename: Francois
authors.initials: F
authors.lastname: Coutlée
authors.affiliation: Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: De Marco
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine UM Cancer Research Institute, University of Malaya, Malaysia.
authors.forename: Yin-Ling
authors.initials: YL
authors.lastname: Woo
authors.affiliation: Department of Microbiology.
authors.forename: Wendy C S
authors.initials: WC
authors.lastname: Ho
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong.
authors.forename: Martin C S
authors.initials: MC
authors.lastname: Wong
authors.affiliation: Department of Obstetrics and Gynecology, University of Zimbabwe, Harare.
authors.forename: Mike Z
authors.initials: MZ
authors.lastname: Chirenje
authors.affiliation: Department of Obstetrics and Gynecology, University of Zimbabwe, Harare.
authors.forename: Tsitsi
authors.initials: T
authors.lastname: Magure
authors.affiliation: Helen Diller Family Comprehensive Cancer Center Department of Pediatrics, University of California-San Francisco.
authors.forename: Anna-Barbara
authors.initials: AB
authors.lastname: Moscicki
authors.affiliation: Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Sabol
authors.affiliation: HPV Research Group, Cancer and Genetics Research Institute, School of Medicine, Cardiff University, United Kingdom.
authors.forename: Alison N
authors.initials: AN
authors.lastname: Fiander
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Zigui
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Microbiology.
authors.forename: Martin C W
authors.initials: MC
authors.lastname: Chan
authors.affiliation: Department of Obstetrics and Gynecology, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Tak-Hong
authors.initials: TH
authors.lastname: Cheung
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burk
authors.affiliation: Department of Microbiology.
authors.forename: Paul K S
authors.initials: PK
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D014943:Global Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D058974:Phylogeography; D015995:Prevalence; D018570:Risk Assessment; D019371:Topography, Medical; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult
keywords: Asia; HPV; cervical cancer; oncogenic risk; phylogeny