title: Influence of oral co-administration of a preparation containing calcium and magnesium and food on enrofloxacin pharmacokinetics.
abstract: The objective of this study has been to determine the influence of food and ions on the pharmacokinetics of enrofloxacin (ENRO) in turkeys, administered per os at a dose of 10 mg/kg of body weight (b.w.). Co-administration of ENRO with ions or with food significantly retarded its absorption, and the interaction was more pronounced when the drug was given together with food. The bioavailability of ENRO was 65.78 ± 7.81% and 47.99 ± 9.48% with ions and food, respectively. The maximum concentration (Cmax) in plasma of animals exposed to ions reached 0.87 ± 0.26 μg/ml in a tmax of 2.07 ± 0.76 h; in animals which were fed while medicated, the analogous parameters were 0.36 ± 0.13 μg/ml and 8.06 ± 3.08 h. The PK/PD analysis demonstrated that a decrease in the concentration of ENRO in turkeys' blood due to the interaction with ions or food might impair the drug's clinical efficacy toward some pathogenic microorganisms in turkeys if a routine dose of 10 mg ENRO/kg b.w. is administered.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland. Electronic address: hubert.ziolkowski@uwm.edu.pl.
authors.forename: Hubert
authors.initials: H
authors.lastname: Ziółkowski
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Jerzy J
authors.initials: JJ
authors.lastname: Jaroszewski
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Maślanka
authors.affiliation: Polpharma Biologics, Trzy lipy Street 3, 80-172 Gdańsk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grabowski
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Katolik
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Pawęska
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Siemianowska
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jasiecka
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Markiewicz
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Spodniewska
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002118:Calcium / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008274:Magnesium / Q000008:administration & dosage*; D013050:Spectrometry, Fluorescence; D014422:Turkeys / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin; D008274:Magnesium; D002118:Calcium
keywords: Enrofloxacin; Food; Ions; Pharmacokinetics; Turkeys