title: A "light-up" and "spectrum-shift" response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging.
abstract: We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a "light-up" and "spectrum-shift" response to target DNA in vitro and could further image the tumor-related mRNA in living cells.
authors.affiliation: Department of Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China. xkpaper@163.com.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: You
authors.forename: Yinping
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Cuiping
authors.initials: C
authors.lastname: Han
authors.forename: Junfeng
authors.initials: J
authors.lastname: Hu
authors.forename: Aming
authors.initials: A
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Zhu
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry*; D012333:RNA, Messenger / Q000032:analysis*; D012834:Silver / Q000737:chemistry*
chemical_list: D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D012333:RNA, Messenger; D012834:Silver