title: Oxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis level.
abstract: BACKGROUND
  The effect of the natural aging process on systemic redox homeostasis is previously documented. However, none of the studies specify the effect of experimental aging on systemic redox homeostasis. The purpose of this study is to clarify the ambiguity raised in preliminary reports as to mimetic aging dependency of the type and magnitude of oxidative damage on constituents of plasma.
  
  
  METHODS
  In the current study, we investigated the interrelationship among various groups of the systemic oxidative damage markers such as protein oxidation products (protein carbonyl groups, protein hydroperoxides, advanced oxidation protein products, protein thiol groups), lipid peroxidation products (malondialdehyde, lipid hydroperoxides, conjugated dienes), glycoxidation adducts (advanced glycation end products), and antioxidant capacity (ferric reducing/antioxidant power, Cu,Zn-superoxide dismutase, total thiol, non-protein thiol). All these markers were measured in plasma of mimetically aged (MA) rats (5-month-old rats subjected to d-galactose-induced experimental aging), naturally aged (NA) rats (24-month-old), and their corresponding young controls (YC) (5months old).
  
  
  CONCLUSIONS
  Our current results show that systemic oxidation markers of the MA group share significant similarities in terms of impaired redox homeostasis with the NA rats and may be considered as a reliable experimental aging model for intravascular aging. Additional methodological studies including d-galactose dosage and application time are warranted to clarify the potential involvement of all these systemic redox variations as mechanistic factors in the development of mimetic aging related intravascular deterioration. Reversing or preventing systemic oxidative damage in experimental and natural aging should therefore be considered the primary target for the development of effective therapeutic strategies to prevent or treat age-related vascular disorders.
authors.affiliation: Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Cebe
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Atukeren
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Karolin
authors.initials: K
authors.lastname: Yanar
authors.affiliation: Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Aylin Irmak
authors.initials: AI
authors.lastname: Kuruç
authors.affiliation: Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Tuna
authors.initials: T
authors.lastname: Ozan
authors.affiliation: Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kunbaz
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Mustafa Erinç
authors.initials: ME
authors.lastname: Sitar
authors.affiliation: Institute of Health Sciences, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Reza
authors.initials: R
authors.lastname: Mirmaroufizibandeh
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Seval
authors.initials: S
authors.lastname: Aydın
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey. Electronic address: cakatay@yahoo.com.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Çakatay
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006706:Homeostasis; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D050050:Protein Carbonylation; D017207:Rats, Sprague-Dawley
chemical_list: D062107:Advanced Oxidation Protein Products; D017127:Glycation End Products, Advanced
keywords: Antioxidant capacity; Glycoxidation adducts; Lipid peroxidation; Natural aging; Protein oxidation; d-Galactose