title: Expression of group XIIA phospholipase A2 in human digestive organs.
abstract: Cellular distribution of group XIIA phospholipase A2 (GXIIA PLA2) was studied in human digestive organs by immunohistochemistry. GXIIA PLA2 protein was detected in epithelial cells of normal gastrointestinal tract, gallbladder and pancreatic acinar cells. The GXIIA PLA2 protein was evenly distributed in the cytoplasm in contrast to secretory granular distribution of GIB PLA2 and GIIA PLA2 in pancreatic acinar cells and small intestinal Paneth cells respectively. Epithelial cells of intestinal glands in Crohn's disease and ulcerative colitis expressed abundant GXIIA PLA2 , whereas inflammatory cells were devoid of the enzyme protein. Tumour cells in colonic adenomas and carcinomas and pancreatic ductogenic carcinomas expressed GXIIA PLA2 protein at varying intensity levels. The putative functions of GXIIA PLA2 remain to be investigated and its role in healthy and diseased digestive organs can only be speculated on at present.
authors.affiliation: Department of Pathology, University of Turku, Turku, Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Peuravuori
authors.forename: Sinikka
authors.initials: S
authors.lastname: Kollanus
authors.forename: Timo J
authors.initials: TJ
authors.lastname: Nevalainen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D003093:Colitis, Ulcerative / Q000235:genetics / Q000473:pathology; D003424:Crohn Disease / Q000235:genetics / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000166:cytology / Q000201:enzymology; D041981:Gastrointestinal Tract / Q000166:cytology / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010179:Pancreas / Q000166:cytology / Q000201:enzymology; D054467:Phospholipases A2 / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D054467:Phospholipases A2
keywords: Group XIIA phospholipase A2; gallbladder; gastrointestinal tract; pancreas