title: Sensorineural hearing loss in congenital diaphragmatic hernia survivors is associated with postnatal management and not defect size.
abstract: OBJECTIVE
  We determined the incidence of sensorineural hearing loss (SNHL; >20dB at any frequency) in a contemporary cohort of congenital diaphragmatic hernia (CDH) survivors at a single tertiary care center and identified potential risk factors for SNHL.
  
  
  METHODS
  From 2000 through 2011, clinical and audiologic data were collected on 122 surgically-repaired Bochdalek CDH patients. CDH defect size, duration of ventilation, and cumulative aminoglycoside treatment were used for multivariate logistic regression.
  
  
  RESULTS
  Incidence of SNHL was 7.4% (9/122). We identified one significant independent predictor of SNHL: cumulative length of aminoglycoside treatment (P<.001; OR 1.44, 95% CI: 1.13-1.83).
  
  
  CONCLUSIONS
  Over the last decade, the incidence of SNHL in our CDH patients is low compared to previous reports in the literature (7.4%) and is not associated with CDH defect size or the need for extracorporeal membrane oxygenation. Prolonged duration of aminoglycoside treatment increases the risk of SNHL independent of defect size and duration of ventilation.
authors.affiliation: Department of Surgery, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Kate V
authors.initials: KV
authors.lastname: Dennett
authors.affiliation: Department of Otolaryngology and Communication Enhancement Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Fligor
authors.affiliation: Department of Surgery, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Tracy
authors.affiliation: Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors.forename: Jay M
authors.initials: JM
authors.lastname: Wilson
authors.affiliation: Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Department of Anesthesia, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Zurakowski
authors.affiliation: Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: catherine.chen@childrens.harvard.edu.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chen
mesh_terms: D001299:Audiometry; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications* / Q000401:mortality / Q000601:surgery; D059685:Herniorrhaphy / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends
keywords: Congenital diaphragmatic hernia; Pediatric surgery; Sensorineural hearing loss