title: Recombinant probiotics with antimicrobial peptides: a dual strategy to improve immune response in immunocompromised patients.
abstract: Bacterial infectious diseases are currently a serious health problem, especially in patients compromised by illness or those receiving immune-suppressant drugs. In this context, it is not only essential to improve the understanding of infectious mechanisms and host response but also to discover novel therapies with extreme urgency. Probiotics and antimicrobial peptides are also favorably viewed as novel strategies in the control of resistant bacteria. The present review will shed some light on the use of probiotic microorganisms expressing antimicrobial peptides as a dual therapy to control bacterial infectious diseases.
authors.affiliation: Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
authors.forename: Santi M
authors.initials: SM
authors.lastname: Mandal
authors.affiliation: Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises, Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brazil; Departamento de Biologia, Programa de Pós-Graduação em Genética e Biotecnologia, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900, Martelos, Juiz de Fora-MG, Brazil.
authors.forename: Osmar N
authors.initials: ON
authors.lastname: Silva
authors.affiliation: Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises, Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brazil; Departamento de Biologia, Programa de Pós-Graduação em Genética e Biotecnologia, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900, Martelos, Juiz de Fora-MG, Brazil. Electronic address: ocfranco@gmail.com.
authors.forename: Octavio L
authors.initials: OL
authors.lastname: Franco
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000276:immunology; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects / Q000276:immunology*; D010455:Peptides / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use; D019936:Probiotics / Q000494:pharmacology* / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D010455:Peptides; D011994:Recombinant Proteins