title: Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention.
abstract: Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of life of older people. The mechanisms underlying sarcopenia are unclear and the development of optimal therapeutic interventions remains elusive. Impaired regenerative capacity, attenuated ability to respond to stress, elevated reactive oxygen species production and low-grade systemic inflammation are all key contributors to sarcopenia. Pharmacological intervention using compounds such as 17AAG, SS-31 and Bimagrumab or naturally occurring polyphenols to target specific pathways show potential benefit to combat sarcopenia although further research is required, particularly to identify the mechanisms by which muscle fibres are completely lost with increasing age.
authors.affiliation: Skeletal Muscle Pathophysiology Research Group, Institute of Ageing and Chronic Disease, Faculty of Health and Life Science, University of Liverpool, UK; MRC Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing, UK.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Lightfoot
authors.affiliation: Skeletal Muscle Pathophysiology Research Group, Institute of Ageing and Chronic Disease, Faculty of Health and Life Science, University of Liverpool, UK; MRC Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: McCormick
authors.affiliation: Skeletal Muscle Pathophysiology Research Group, Institute of Ageing and Chronic Disease, Faculty of Health and Life Science, University of Liverpool, UK; MRC Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing, UK.
authors.forename: Gareth A
authors.initials: GA
authors.lastname: Nye
authors.affiliation: Skeletal Muscle Pathophysiology Research Group, Institute of Ageing and Chronic Disease, Faculty of Health and Life Science, University of Liverpool, UK; MRC Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing, UK. Electronic address: mdcr02@liv.ac.uk.
authors.forename: Anne
authors.initials: A
authors.lastname: McArdle
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D055948:Sarcopenia / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins; D017382:Reactive Oxygen Species