title: Molecular profiling of breast cancer.
abstract: Breast cancer is now considered a heterogeneous and phenotypically diverse disease. Molecular profiling is used in clinical practice in 2 broad categories: (1) characterization of breast cancers beyond the standard histopathologic features such as tumor grade, histologic subtype, and biomarker profile for prognostic information; and (2) prediction of response to therapy and clinical outcome. This article addresses the importance and application of molecular subtype analysis, and provides an in-depth analysis of the clinical application of the molecular prognostic indices for ductal carcinoma in situ, node-negative invasive breast cancer, and node-positive invasive breast cancer.
authors.affiliation: Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Cyr
authors.affiliation: Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA. Electronic address: margenthalerj@wudosis.wustl.edu.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Margenthaler
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics* / Q000628:therapy; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D011379:Prognosis
keywords: Breast cancer; Genome; Molecular diagnostics; Molecular profiling; Prognostication