title: New experimental models of skin homeostasis and diseases.
abstract: Homeostasis, whose regulation at the molecular level is still poorly understood, is intimately related to the functions of epidermal stem cells. Five research groups have been brought together to work on new in vitro and in vivo skin models through the SkinModel-CM program, under the auspices of the Spanish Autonomous Community of Madrid. This project aims to analyze the functions of DNA methyltransferase 1, endoglin, and podoplanin in epidermal stem cell activity, homeostasis, and skin cancer. These new models include 3-dimensional organotypic cultures, immunodeficient skin-humanized mice, and genetically modified mice. Another aim of the program is to use skin-humanized mice to model dermatoses such as Gorlin syndrome and xeroderma pigmentosum in order to optimize new protocols for photodynamic therapy.
authors.affiliation: Unidad de Medicina Regenerativa, Departamento de Investigación Básica, División de Biomedicina Epitelial, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) y Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Larcher
authors.affiliation: Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid (UAM), Madrid, España; Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-UAM, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Espada
authors.affiliation: Unidad de Dermatología, Hospital Ramón y Cajal, Madrid, España.
authors.forename: B
authors.initials: B
authors.lastname: Díaz-Ley
authors.affiliation: Unidad de Dermatología, Hospital Ramón y Cajal, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: Jaén
authors.affiliation: Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid (UAM), Madrid, España. Electronic address: angeles.juarranz@uam.es.
authors.forename: A
authors.initials: A
authors.lastname: Juarranz
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-UAM, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Quintanilla
mesh_terms: D000818:Animals; D035843:Biomedical Research; D004195:Disease Models, Animal; D018859:Hair Follicle; D006706:Homeostasis; D006801:Humans; D051379:Mice; D023421:Models, Animal; D008957:Models, Genetic; D010778:Photochemotherapy; D012871:Skin Diseases / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D012879:Skin Physiological Phenomena; D013234:Stem Cells
keywords: ADN metil transferasa 1; Células madre epidérmicas; DNA methyltransferase 1; Endoglin; Endoglina; Epidermal stem cells; Equivalentes cutáneos 3D; Genetically modified mice; Photodynamic therapy; Podoplanin; Podoplanina; Programa SkinModel-CM; Ratones con piel humanizada; Ratones modificados genéticamente; Skin-humanized mice; SkinModel-CM software; Terapia fotodinámica; Three-dimensional skin equivalents