title: Impact of benign prostatic hyperplasia pharmacological treatment on transrectal prostate biopsy adverse effects.
abstract: Background. Benign prostatic hyperplasia (BPH) pharmacological treatment may promote a decrease in prostate vascularization and bladder neck relaxation with theoretical improvement in prostate biopsy morbidity, though never explored in the literature. Methods. Among 242 consecutive unselected patients who underwent prostate biopsy, after excluding those with history of prostate biopsy/surgery or using medications not for BPH, we studied 190 patients. On the 15th day after procedure patients were questioned about symptoms lasting over a week and classified according to pharmacological BPH treatment. Results. Thirty-three patients (17%) were using alpha-blocker exclusively, five (3%) 5-alpha-reductase inhibitor exclusively, twelve (6%) patients used both medications, and 140 (74%) patients used none. There was no difference in regard to age among groups (P = 0.5). Postbiopsy adverse effects occurred as follows: hematuria 96 (50%), hematospermia 53 (28%), hematochezia 22 (12%), urethrorrhagia 19 (10%), fever 5 (3%), and pain 20 (10%). There was a significant negative correlation between postbiopsy hematuria and BPH pharmacological treatment with stronger correlation for combined use of 5-alpha-reductase inhibitor and alpha-blocker over 6 months (P = 0.0027). Conclusion. BPH pharmacological treatment, mainly combined for at least 6 months seems to protect against prostate biopsy adverse effects. Future studies are necessary to confirm our novel results.
authors.affiliation: Urology Division, Faculty of Medicine, Pontifical Catholic University of Campinas (PUC-Campinas), 13083-970 Campinas, SP, Brazil.
authors.forename: Marina
authors.identifier: 0000-0003-2746-0894
authors.initials: M
authors.lastname: Zamuner
authors.affiliation: Dr. Mario Gatti County Hospital, 13083-970 Campinas, SP, Brazil.
authors.forename: Ciro Eduardo
authors.initials: CE
authors.lastname: Falcone
authors.affiliation: Dr. Mario Gatti County Hospital, 13083-970 Campinas, SP, Brazil.
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Amstalden Neto
authors.affiliation: Urology Division, Department of Surgery, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Tomás Bernardo Costa
authors.initials: TB
authors.lastname: Moretti
authors.affiliation: Department of Genetics, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Magna
authors.affiliation: Urology Division, Department of Surgery, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Fernandes
authors.initials: F
authors.lastname: Denardi
authors.affiliation: Urology Division, Faculty of Medicine, Pontifical Catholic University of Campinas (PUC-Campinas), 13083-970 Campinas, SP, Brazil ; Urology Division, Department of Surgery, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil ; Department of Urology, School of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Leonardo Oliveira
authors.initials: LO
authors.lastname: Reis