title: Surface charge switching nanoparticles for magnetic resonance imaging.
abstract: In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea. Electronic address: oytaik@yumc.yonsei.ac.kr.
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea. Electronic address: eslee@catholic.ac.kr.
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008819:Mice, Nude; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D010316:Particle Size; D011107:Polylysine / Q000737:chemistry*; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; C000595246:deoxycholic acid-b-poly(Lys-2,3-dimethylmaleic acid); D003840:Deoxycholic Acid; D011107:Polylysine
keywords: Fe(3)O(4); Magnetic resonance imaging (MRI); Surface charge switching nanoparticle; pH-Responsive