title: Population pharmacokinetic analysis of ciprofloxacin in the elderly patients with lower respiratory tract infections.
abstract: The aims of the study were to develop a population pharmacokinetic model of ciprofloxacin (CPX) in the elderly patients and to examine the impact of patient-dependent variables on pharmacokinetic parameter values of this drug. The study was conducted in a group of 44 patients at the age of 44-96years, hospitalized due to pneumonia lobaris or bronchopneumonia. Patients received CPX at a dose of 200mg every 12h as a constant rate infusion over 0.5h. Concentrations of CPX in serum were measured by HPLC with UV detection. Population pharmacokinetic analysis revealed that CPX concentration versus time data were best described by a one-compartment model. The mean values of volume of distribution and clearance of CPX in the patients above 65years of age were 78.41±13.17L and 18.39±4.15L/h, respectively. The creatinine clearance influenced CPX clearance according to the equation: CLCPX (L/h)=8.0+0.21·CLCr, while the volume of distribution of CPX was dependent on the body weight of the patient as follows: VdCPX (L)=22.72+0.86·WT. In summary, the developed population model can be used to assess the pharmacokinetic parameters of CPX in the elderly patients and to select on the basis of these parameters and MIC values an optimal dosage regimen of this drug.
authors.affiliation: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, Medical College, 9 Medyczna St, 30-688 Cracow, Poland. Electronic address: agnus.cios@interia.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cios
authors.affiliation: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, Medical College, 9 Medyczna St, 30-688 Cracow, Poland. Electronic address: mfwyska@cyf-kr.edu.pl.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Wyska
authors.affiliation: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, Medical College, 9 Medyczna St, 30-688 Cracow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Szymura-Oleksiak
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University, Medical College, 10 Sniadeckich St, 31-531 Cracow, Poland. Electronic address: tomekg@su.krakow.mp.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzicki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin
keywords: Ciprofloxacin; Dosage recommendations; Elderly patients; Population pharmacokinetics