title: Hidradenitis suppurativa: a retrospective study of 846 Dutch patients to identify factors associated with disease severity.
abstract: BACKGROUND
  Few comprehensive studies exist on the epidemiology of hidradenitis suppurativa, a very distressing skin disease.
  
  
  OBJECTIVE
  We sought to identify disease-related factors associated with severity, sex, and family history.
  
  
  METHODS
  Ordinal logistic regression was used in 846 consecutive Dutch patients with hidradenitis suppurativa to calculate odds ratios (ORs) for severity according to Hurley. Sex and family history were compared using Student t test and χ(2) test.
  
  
  RESULTS
  In total, 45.5% of the patients had Hurley I, 41.5% had Hurley II, and 13.0% had Hurley III. Severity was associated with male sex (OR 2.11; P < .001), disease duration (OR 1.03; P < .001), body mass index (OR 1.03; P = .01), smoking pack-years (OR 1.02; P = .001), and axillary (OR 2.24; P < .001), perianal (OR 1.92; P < .001), and mammary lesions (OR 1.48; P = .03). Women had earlier onset, more inguinal and mammary lesions, and more frequent family history for hidradenitis suppurativa. Men more commonly had gluteal, perianal, and atypical lesions, and a history of severe acne. Patients with a family history had earlier onset, longer disease duration, a history of severe acne, more extensive disease, and were more often smokers.
  
  
  CONCLUSIONS
  Some parameters were patient-reported.
  
  
  CONCLUSIONS
  The severity risk factors identified in this study could help physicians to select patients who need close monitoring and who would benefit from early, aggressive therapy.
authors.affiliation: Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Anne M R
authors.initials: AM
authors.lastname: Schrader
authors.affiliation: Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Inge E
authors.initials: IE
authors.lastname: Deckers
authors.affiliation: Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Hessel H
authors.initials: HH
authors.lastname: van der Zee
authors.affiliation: Department of Dermatology, Deventer Hospital, Deventer, The Netherlands.
authors.forename: Jurr
authors.initials: J
authors.lastname: Boer
authors.affiliation: Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: e.prens@erasmusmc.nl.
authors.forename: Errol P
authors.initials: EP
authors.lastname: Prens
mesh_terms: D017668:Age of Onset; D015992:Body Mass Index; D005260:Female; D017497:Hidradenitis Suppurativa / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D016017:Odds Ratio; D012189:Retrospective Studies; D012907:Smoking / Q000453:epidemiology
keywords: Hurley stage; acne inversa; body mass index; cigarette smoking; disease severity; epidemiology; family history; obesity; risk factors; sex; smoking pack-years