title: Graphene-cyclodextrin-cytochrome c layered assembly with improved electron transfer rate and high supramolecular recognition capability.
abstract: This study aimed to develop a new graphene-based layered assembly, named graphene-cyclodextrin-cytochrome c with improved electron transfer rate. This assembly has combined high conductivity of graphene nanosheets (GNs), selectively binding properties and electronegativity of cyclodextrins (CDs), as well as electropositivity of cytochrome c (Cyt c). This assembly can also mimic the confined environments of the intermembrane space of mitochondria. A β-cyclodextrin (β-CD) functionalized GN (GN-CD) assembly was initially prepared by a simple wet-chemical strategy, i.e., in situ thermal reduction of graphene oxide with hydrazine hydrate in the presence of β-CD. Cyt c was then intercalated to the GN-CD assembly to form a layered self-assembled structure, GN-CD-Cyt c, through electrostatic interaction. Compared with GNs and GN-CD, GN-CD-Cyt c assembly displayed improved electron transfer rate and high supramolecular recognition capability toward six probe molecules.
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Gong
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Guo
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Jiang
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, China. Electronic address: qiantang@swu.edu.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: Tang
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.
authors.forename: Xue-Bing
authors.initials: XB
authors.lastname: Ma
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D045304:Cytochromes c / Q000737:chemistry*; D004563:Electrochemistry; D004579:Electron Transport; D004583:Electrons; D006108:Graphite / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D006108:Graphite; D045304:Cytochromes c
keywords: Cyclodextrins; Cytochrome c; Graphene; Graphene–cyclodextrin–cytochrome c; Supramolecular recognition