title: Biphasic β-TCP mixed with silicon increases bone formation in critical site defects in rabbit calvaria.
abstract: OBJECTIVE
  The aim of this study was to assess the bone regeneration of critical size defects in rabbit calvarias filled with β-TCP doped with silicon.
  
  
  METHODS
  Twenty-one New Zealand rabbits were used in this study. Two critical size defects were created in the parietal bones. Three experimental groups were evaluated: Test A (HA/β-TCP granules alone), Test B (HA/β-TCP granules plus 3% silicon), Control (empty defect). The animals were sacrificed at 8 and 12 weeks. Evaluation was performed by μCT analysis and histomorphometry.
  
  
  RESULTS
  μCT evaluation showed higher volume reduction in Test A group compared with Test B (P < 0.05). The Test B group showed the highest values for cortical closure and bone formation around the particles, followed by Test A and controls (P < 0.05).
  
  
  CONCLUSIONS
  Within the limitations of this animal study, it can be concluded that HA/β-TCP plus 3% silicon increases bone formation in critical size defects in rabbit calvarias, and the incorporation of 3% silicon reduces the resorption rate of the HA/β-TCP granules.
authors.affiliation: General & Implant Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calvo-Guirado
authors.affiliation: Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.|National University of San Juan, San Juan, Argentine.
authors.forename: Miguel
authors.initials: M
authors.lastname: Garces
authors.affiliation: Department of Prosthodontics and Digital Technology, Stony Brook University, School of Dental Medicine, Stony Brook, NY, USA.
authors.forename: Rafael Arcesio
authors.initials: RA
authors.lastname: Delgado-Ruiz
authors.affiliation: General & Implant Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Ramirez Fernandez
authors.affiliation: International University of Catalonia, Barcelona, Spain.
authors.forename: Eduard
authors.initials: E
authors.lastname: Ferres-Amat
authors.affiliation: Department of Dental Medicine, Stony Brook University, School of Dental Medicine, Stony Brook, NY, USA.
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Romanos
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000494:pharmacology*; D017886:Durapatite / Q000138:chemical synthesis / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000187:drug effects*; D010294:Parietal Bone / Q000601:surgery*; D011817:Rabbits; D012825:Silicon / Q000494:pharmacology*; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite; D012825:Silicon
keywords: bone graft; bone substitutes; silicon; skull rabbits; β-TCP