title: Solid-phase synthesis of trisubstituted 2,5-dihydrobenzo[f][1,2,5]thiadiazepine 1,1-dioxide derivatives.
abstract: The solid-phase synthesis of trisubstituted 2,5-dihydrobenzo[f][1,2,5]thiadiazepine 1,1-dioxides is reported. Acyclic polymer-supported intermediates were prepared using commercially available building blocks: Fmoc-protected amino acids, 2-nitrobenzenesulfonyl chlorides, and bromoketones. The acyclic precursors underwent acid-mediated release from the resin and the cyclization was completed in solution.
authors.affiliation: Department of Organic Chemistry, Institute of Molecular and Translational Medicine, Faculty of Science, Palacky University , 17. Listopadu 12, 771 46 Olomouc, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Fülöpová
authors.forename: Viktor
authors.initials: V
authors.lastname: Krchňák
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D003500:Cyclization; D005449:Fluorenes / Q000737:chemistry; D054879:Halogenation; D007659:Ketones / Q000737:chemistry; D009578:Nitrobenzenes / Q000737:chemistry; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001555:Benzene Derivatives; D002712:Chlorides; D005449:Fluorenes; D007659:Ketones; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D009578:Nitrobenzenes; D010087:Oxides; D013841:Thiazepines; C036077:nitrobenzene