title: [Reproductive toxicity of ethylparaben on male Drosophila melanogaster].
abstract: OBJECTIVE
  To investigate the reproductive toxicity of different concentration of ethylparaben (EP) on male Drosophila.
  
  
  METHODS
  New eclosion flies within 8h in the basal medium were collected and male Drosophila among them were put into control group and EP treating groups with different concentration (0.03%, 0.07% and 0.10%) by random selection. Female Drosophila was all put into control group. After cultured for 5 days by one pair in one tube and 10 times of repetition for each group, the egg laying amount and maximum egg laying amount of 10d parental generation (F0) and first filial generation (F1), the emergence rate and emergence amount of F1 and second finial generation (F2), the duration time of eggs-arvae, larvae-pupa, and pupa-adult flies, and the total duration time of emergence were counted.
  
  
  RESULTS
  The egg laying amount, emergence rate and emergence amount of EP treated parental Drosophila were significantly lower than those of the control group (P < 0.01). The total duration time of emergence of F1 prolongs with the increase of EP concentration. The egg laying amount of F1 and emergence rate of F2 in high EP concentration group had remarkable different compared to those of control group (P < 0.01). And the total duration time of F2 had also shortened significantly compared to that of control group (P < 0.05), while there was no remarkable difference in 0.03% and 0.07% concentration group.
  
  
  CONCLUSIONS
  EP has a certain reproductive toxicity to F0 male Drosophila and EP of high concentration can impact sustainable to offspring which has some facilitation effect on F1 Drosophila.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhao
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster; D005260:Female; D008297:Male; D010226:Parabens / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects*
chemical_list: D010226:Parabens