title: The role of Staphylococcus epidermidis in neonatal sepsis: guarding angel or pathogenic devil?
abstract: Neonatal late-onset sepsis (LOS) is a serious problem in neonatal intensive care. Coagulase-negative staphylococci, especially Staphylococcus epidermidis, have emerged as the predominant pathogen of LOS in very low birth weight (VLBW) infants, accounting for up to 77.9% of neonatal LOS in industrialized countries and 46.5% in some developing regions. VLBW neonates with indwelling medical devices are most susceptible for S. epidermidis sepsis, the incidence rate of which is approximately 25%. However, S. epidermidis primarily plays a commensal role on human host and is of evolutionary importance to newborns, by inhibiting virulent pathogens and educating the innate immune system. Recent advances in molecular microbiology show that S. epidermidis is a bacterial species equipped with remarkable genetic flexibility, and can employ a multitude of mechanisms to become adapted to the changing environment. Extrinsic factors in the neonatal ward, such as the interruption of skin barrier by medical devices and the selective pressure due to antibiotics, contribute to the conversion of S. epidermidis from a member of the skin microflora to an infectious agent. Furthermore, neonates are predisposed for S. epidermidis infections due to their distinct immunological characteristics. A better understanding of the dichotomy of S. epidermidis and the underlying mechanisms may inspire new anti-infectious strategies.
authors.affiliation: University Children's Hospital, University of Würzburg, Würzburg, Germany; Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing and Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China'
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.affiliation: University Children's Hospital, University of Würzburg, Würzburg, Germany. Electronic address: speer_c@ukw.de.
authors.forename: Christian P
authors.initials: CP
authors.lastname: Speer
mesh_terms: D055499:Catheter-Related Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D018805:Sepsis / Q000453:epidemiology / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000302:isolation & purification*
keywords: Biofilm formation; Immunity; Nosocomial infections; Preterm infants; Staphylococcus epidermidis