title: [Squamous cell carcinoma of the hypopharynx and larynx: evidence-based care].
abstract: Squamous cell carcinomas of larynx and hypopharynx can be treated by surgery and/or radiotherapy according to tumor size. For small tumors, the results are similar. For locally advanced tumors, the surgical approach is mutilating and requires a total (pharyngo)laryngectomy. Exclusive chemoradiotherapy has shown its interest at the cost of late sequelae. In order to reduce these effects and mutilation, induction chemotherapy with cisplatin, docetaxel and 5FU for organ preservation becomes the standard treatment but there are no solid studies comparing this approach with the exclusive chemoradiotherapy. And it is not possible to conclude as to the superiority of a scheme in terms of overall survival. When chemotherapy is chosen, the modalities of any potentiation of radiation have not been yet established.
authors.affiliation: Université de Lyon, Centre Léon-Bérard, Service de médecine, 28, rue Laennec, 69008 Lyon, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Fayette
authors.affiliation: Centre Jean-Bernard, Clinique Victor-Hugo, Service de radiothérapie, 9, rue Beauverger 72000 Le Mans, France.
authors.forename: Yoann
authors.initials: Y
authors.lastname: Pointreau
authors.affiliation: Centre hospitalier universitaire Vaudois, Service de radiothérapie, 46, rue du Bugnon, 1011 Lausanne, Suisse.
authors.forename: Jean
authors.initials: J
authors.lastname: Bourhis
authors.affiliation: Centre Oscar-Lambret, Service de chirurgie maxillofaciale, 3, rue Frédéric-Combemale, 59000 Lille, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Lefebvre
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging / Q000379:methods; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents
keywords: TPF; chemoradiotherapy; hypopharynx; induction; larynx