title: Sodium selenite and vitamin E in preventing mercuric chloride induced renal toxicity in rats.
abstract: This study aims to investigate improving effects of sodium selenite and/or vitamin E on mercuric chloride-induced kidney impairments in rats. Wistar male rats were exposed either to sodium selenite (0.25mg/kgday), vitamin E (100mg/kgday), sodium selenite+vitamin E, mercuric chloride (1mg/kgday), sodium selenite+mercuric chloride, vitamin E+mercuric chloride and sodium selenite+vitamin E+mercuric chloride for 4weeks. Mercuric chloride exposure resulted in an increase in the uric acid, creatinine, blood urea nitrogen and malondialdehyde (MDA) levels and a decrease in the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. Histopathological changes were detected in kidney tissues in mercuric chloride-treated groups. A significant decrease in the uric acid, creatinine, blood urea nitrogen and MDA levels and a significant increase in the SOD, CAT and GPx activities were observed in the supplementation of sodium selenite and/or vitamin E to mercuric chloride-treated groups. Conclusively, sodium selenite, vitamin E and vitamin E+sodium selenite significantly reduce mercuric chloride induced nephrotoxicity in rats, but not protect completely.
authors.affiliation: Gazi University, Vocational High School of Health Services, Ankara, Turkey. Electronic address: aogutcu@gazi.edu.tr.
authors.forename: Ayse
authors.initials: A
authors.lastname: Aslanturk
authors.affiliation: Gazi University, Vocational High School of Health Services, Ankara, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Uzunhisarcikli
authors.affiliation: Gazi University, Gazi Education Faculty, Department of Science Education, Ankara, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Kalender
authors.affiliation: Gaziosmanpaşa University, Graduate School of Natural and Applied Sciences, Tokat, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Demir
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000097:blood; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008627:Mercuric Chloride / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D014527:Uric Acid; D008315:Malondialdehyde; D008627:Mercuric Chloride; D003404:Creatinine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D018038:Sodium Selenite
keywords: Histopathology; Kidney toxicity; Mercuric chloride; Oxidative stress; Sodium selenite; Vitamin E