title: Predictive factors for neutropenia after docetaxel-based systemic chemotherapy in Korean patients with castration- resistant prostate cancer.
abstract: The aim of this study was to determine predictive factors for neutropenia after docetaxel-based systemic chemotherapy in patients with castration-resistant prostate cancer (CRPC). The study included 40 Korean CRPC patients who were treated with several cycles of docetaxel plus prednisolone from May 2005 to May 2012. Patients were evaluated for neutropenia risk factors and for the incidence of neutropenia. In this study, nine out of forty patients (22.5%) developed neutropenia during the first cycle of docetaxel-based systemic chemotherapy. Four experienced grade 2, three grade 3, and one grade 4 neutropenia. Multivariate analysis showed that pretreatment white blood cell (WBC) count (p=0.042), pretreatment neutrophil count (p=0.015), pretreatment serum creatinine level (p=0.027), and pretreatment serum albumin level (p=0.017) were significant predictive factors for neutropenia. In conclusion, pretreatment WBC counts, neutrophil counts, serum creatinine levels, and serum albumin levels proved to be significant independent risk factors for the development of neutropenia induced by docetaxel-based systemic chemotherapy in patients with CRPC.
authors.affiliation: Department of Urology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Republic of Korea E-mail : sc.park@wonkwang.ac.kr.
authors.forename: Whi-An
authors.initials: WA
authors.lastname: Kwon
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Oh
authors.forename: Jae Whan
authors.initials: JW
authors.lastname: Lee
authors.forename: Seung Chol
authors.initials: SC
authors.lastname: Park
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D000077143:Docetaxel; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced*; D009504:Neutrophils / Q000166:cytology*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000097:blood / Q000188:drug therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D012709:Serum Albumin; D043823:Taxoids; D000077143:Docetaxel; D003404:Creatinine