title: Effect of myrtle fruit syrup on abnormal uterine bleeding: a randomized double-blind, placebo-controlled pilot study.
abstract: BACKGROUND
  Myrtle (Myrtus communis L.) has been used in the Iranian Traditional Medicine as a treatment for abnormal uterine bleeding-menometrorrhagia. The main aim of this study is to evaluate the effect of myrtle fruit syrup on abnormal uterine bleeding-menometrorrhagia.
  
  
  METHODS
  A randomized, double-blind, placebo-controlled pilot study was conducted on 30 women suffering from abnormal uterine bleeding-menometrorrhagia. Treatment comprised of giving 15 ml oral myrtle syrup daily (5 ml three times a day) for 7 days starting from the onset of bleeding. The myrtle syrup along with placebo was repeated for 3 consecutive menstrual periods. Menstrual duration and number of used pads were recorded by the Pictorial Blood loss Assessment Chart at the end of each menstrual period. The quality of life was also evaluated using the menorrhagia questionnaire.
  
  
  RESULTS
  The mean number of bleeding days significantly declined from 10.6 ± 2.7 days to 8.2 ± 1.9 days after 3 months treatment with the syrup (p = 0.01) and consequently the participants in the intervention group used fewer pads after 3 months (16.4 ± 10.7) compared with the number of pads used at the beginning of the treatment (22.7 ± 12.0, p = 0.01). Bleeding days and number of pads used by the participants in the placebo group did not change significantly. Also significant changes of quality of life scores were observed in the intervention group after 3 months compared to the baseline.
  
  
  CONCLUSIONS
  Myrtle syrup is introduced as a potential remedy for abnormal uterine bleeding-menometrorrhagia.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Qaraaty
authors.affiliation: Department of Traditional Medicine, Faculty of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. kamaliseyyedhamid@yahoo.com.
authors.forename: Seyed Hamid
authors.initials: SH
authors.lastname: Kamali
authors.forename: Fataneh Hashem
authors.initials: FH
authors.lastname: Dabaghian
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Zafarghandi
authors.forename: Roshanak
authors.initials: R
authors.lastname: Mokaberinejad
authors.forename: Masumeh
authors.initials: M
authors.lastname: Mobli
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Amin
authors.forename: Mohsen
authors.initials: M
authors.lastname: Naseri
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamalinejad
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amin
authors.forename: Azizeh
authors.initials: A
authors.lastname: Ghaseminejad
authors.forename: Seyedeh Jihan
authors.initials: SJ
authors.lastname: HosseiniKhabiri
authors.forename: Daryush
authors.initials: D
authors.lastname: Talei
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008519:Medicine, Traditional; D008796:Metrorrhagia / Q000188:drug therapy*; D008875:Middle Aged; D031651:Myrtus / Q000737:chemistry*; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000627:therapeutic use; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts