title: Hemoglobin-based oxygen carrier attenuates cerebral damage by improving tissue oxygen preload in a dog model of cardiopulmonary bypass.
abstract: In order to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuates cardiopulmonary bypass (CPB)-induced cerebral damage. Male adult Beagle dogs were randomly divided into sham, control, and HBOC groups. After establishment of CPB model, hearts were arrested for 2 h and reperfused for 2 h. HBOC improved intracerebral O2 tensions and reduced the releases of biomarkers for cerebral damage, including neuron-specific enolase and S100β in both cerebrospinal fluid and serum. Moreover, HBOC attenuated the releases of tumor necrosis factor-α and interleukin-1β after CPB. Therefore, our findings suggest that HBOC could reduce cerebral damage after CPB, which was probably associated with improvement of tissue O2 preload.
authors.affiliation: Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan , P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Chengmin
authors.initials: C
authors.lastname: Yang
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001802:Blood Substitutes / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; D053583:Interleukin-1beta; D064568:S100 Calcium Binding Protein beta Subunit; D014409:Tumor Necrosis Factor-alpha; D010751:Phosphopyruvate Hydratase; D010100:Oxygen
keywords: brain; cardiopulmonary bypass; hemoglobin-based oxygen carrier; inflammation; ischemia/reperfusion injury