title: Translating the molecular analysis of cancer biology into therapeutic concepts.
abstract: The rapidly evolving understanding of tumour biology offers novel opportunities for therapeutic interventions. This information already has been used to select appropriate systemic treatment. To take full advantage of this knowledge, however, the different levels of interaction in an organism need to be integrated to link cellular mechanisms, stromal effects and the implications for organs and the whole organism. Although very challenging and ambitious, this understanding would closely link tumour biology, biomarker validation and rational therapeutic decisions.
authors.affiliation: Department of Medicine, Clinical Division of Oncology, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Mader
authors.affiliation: Department of Medicine, Clinical Division of Oncology, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brodowicz
authors.affiliation: Department of Medicine, Clinical Division of Oncology, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria.
authors.forename: Christoph C
authors.initials: CC
authors.lastname: Zielinski
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology; D014408:Biomarkers, Tumor; D000068818:Cetuximab; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D044127:Epigenesis, Genetic / Q000187:drug effects*; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D057170:Translational Research, Biomedical
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; C512478:EGFR protein, human; D066246:ErbB Receptors; D000068818:Cetuximab
keywords: Cancer biology; predictive biomarkers; translational research