title: HeteroGenome: database of genome periodicity.
abstract: We present the first release of the HeteroGenome database collecting latent periodicity regions in genomes. Tandem repeats and highly divergent tandem repeats along with the regions of a new type of periodicity, known as profile periodicity, have been collected for the genomes of Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans and Drosophila melanogaster. We obtained data with the aid of a spectral-statistical approach to search for reliable latent periodicity regions (with periods up to 2000 bp) in DNA sequences. The original two-level mode of data presentation (a broad view of the region of latent periodicity and a second level indicating conservative fragments of its structure) was further developed to enable us to obtain the estimate, without redundancy, that latent periodicity regions make up ~10% of the analyzed genomes. Analysis of the quantitative and qualitative content of located periodicity regions on all chromosomes of the analyzed organisms revealed dominant characteristic types of periodicity in the genomes. The pattern of density distribution of latent periodicity regions on chromosome unambiguously characterizes each chromosome in genome. Database URL: http://www.jcbi.ru/lp_baze/
authors.affiliation: Laboratory of Bioinformatics, Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya st. 4, 142290 Pushchino, Russia and Department of Computational Mathematics and Mathematical Physics, Moscow State Technical University n.a. N.E. Bauman, the 2nd Baumanskaya st., 5, 105005 Moscow, Russia maramaria@yandex.ru.
authors.forename: Maria
authors.initials: M
authors.lastname: Chaley
authors.affiliation: Laboratory of Bioinformatics, Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya st. 4, 142290 Pushchino, Russia and Department of Computational Mathematics and Mathematical Physics, Moscow State Technical University n.a. N.E. Bauman, the 2nd Baumanskaya st., 5, 105005 Moscow, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kutyrkin
authors.affiliation: Laboratory of Bioinformatics, Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya st. 4, 142290 Pushchino, Russia and Department of Computational Mathematics and Mathematical Physics, Moscow State Technical University n.a. N.E. Bauman, the 2nd Baumanskaya st., 5, 105005 Moscow, Russia.
authors.forename: Gayane
authors.initials: G
authors.lastname: Tulbasheva
authors.affiliation: Laboratory of Bioinformatics, Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya st. 4, 142290 Pushchino, Russia and Department of Computational Mathematics and Mathematical Physics, Moscow State Technical University n.a. N.E. Bauman, the 2nd Baumanskaya st., 5, 105005 Moscow, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Teplukhina
authors.affiliation: Laboratory of Bioinformatics, Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya st. 4, 142290 Pushchino, Russia and Department of Computational Mathematics and Mathematical Physics, Moscow State Technical University n.a. N.E. Bauman, the 2nd Baumanskaya st., 5, 105005 Moscow, Russia.
authors.forename: Nafisa
authors.initials: N
authors.lastname: Nazipova
mesh_terms: D000818:Animals; D001483:Base Sequence; D002875:Chromosomes / Q000235:genetics; D030541:Databases, Genetic; D016678:Genome / Q000235:genetics*; D054629:Genome, Mitochondrial / Q000235:genetics; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013223:Statistics as Topic