title: The use of controlled release locally delivered 10% doxycycline hyclate gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: clinical and microbiological results.
abstract: BACKGROUND
  Local delivery of antimicrobial agents provides higher concentration of the drug in the periodontal site for longer periods than systemically delivered methods. In the present study an attempt is made to know the efficacy of controlled local drug delivery of doxycycline as an adjunctive treatment in the management of chronic periodontitis.
  
  
  METHODS
  A total of 12 patients, diagnosed as Chronic Periodontitis in the age of 25 to 55 years, were selected of both the sexes in this study. They were divided into Experimental group consisted of 30 sites who received complete scaling and root planing (SRP) followed by placement of Atridox gel and control group consisted of 30 sites who received only SRP. Clinical parameters were recorded at, baseline, days 30, 90 and 180. Parameters were plaque index, gingival index, gingival bleeding index and microbial analysis, probing pocket depth and Clinical attachment level (CAL). The microbiological analysis was done at baseline visit and at 90th day. Probing pocket depth and CAL were recorded only on day 0 and 180th day.
  
  
  RESULTS
  In 180 days study, both the groups exhibited a significant improvement in periodontal status. Significant gain in attachment level was observed in both the group. Between both the groups the clinical parameters in the experimental groups exhibited better results as compared to the control group. Both the groups exhibited significant reduction in the number of spirochetes.
  
  
  CONCLUSIONS
  Combination therapy of SRP and 10% DH gel demonstrated better results at all levels suggesting that this therapy can play a significant role as an adjunct to SRP in the management of chronic periodontitis.
authors.affiliation: Associate Professor, Department of Periodontics, Malabar Dental College, Edapal, Kerala, India, Phone: 9746074655, e-mail: drshabeer9582@gmail.com.
authors.forename: Shabeer
authors.initials: S
authors.lastname: Ahamed
authors.affiliation: Reader, Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Bhubaneswar-24, Odisha, India.
authors.forename: Md
authors.initials: M
authors.lastname: Jalaluddin
authors.affiliation: Reader, Department of Oral and Maxillofacial Surgery, MGM Dental College, Navi Mumbai, Maharashtra, India.
authors.forename: Imran
authors.initials: I
authors.lastname: Khalid
authors.affiliation: Professor and Head, Department of Periodontics, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Ninad
authors.initials: N
authors.lastname: Moon
authors.affiliation: Reader, Department of Periodontics, Kannur Dental College, Kannur, Kerala, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Shaf
authors.affiliation: Reader, Department of Oral and Maxillofacial Surgery, SMBT Dental College, Sangamner Taluka, Maharashtra, India.
authors.forename: Fareedi Mukram
authors.initials: FM
authors.lastname: Ali
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D058491:Bacterial Load / Q000187:drug effects; D055113:Chronic Periodontitis / Q000382:microbiology / Q000628:therapy*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000382:microbiology / Q000628:therapy; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods*; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000382:microbiology / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D016745:Root Planing / Q000379:methods*; D013144:Spirochaetales / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D005782:Gels; D004318:Doxycycline