title: The role of the autophagy in myocardial ischemia/reperfusion injury.
abstract: Autophagy is an intracellular process responsible for damaged or unnecessary protein and organelle degradation. In the heart, autophagy occurs at basal level and dysregulated autophagy is associated with a variety of cardiovascular diseases. Autophagy is enhanced in ischemia as well as in the reperfusion phase during cardiac ischemia reperfusion (I/R) injury. More importantly, recent studies revealed that autophagy exerted both beneficial and detrimental effects in pathology of cardiac ischemia reperfusion. This paper is to review the functional significance of autophagy in cardiac ischemia reperfusion injury and discuss underlying signaling pathways. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases.
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, 28# Fuxing Street, Beijing 100852, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 127# Changle West Road, Xi'an, Shaanxi 710032, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 127# Changle West Road, Xi'an, Shaanxi 710032, China.
authors.forename: Yabin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, 28# Fuxing Street, Beijing 100852, China.
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Chinese PLA General Hospital, 28# Fuxing Street, Beijing 100852, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 127# Changle West Road, Xi'an, Shaanxi 710032, China. Electronic address: wind8828@gmail.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D008954:Models, Biological; D009203:Myocardial Infarction / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000473:pathology*; D015398:Signal Transduction
keywords: Autophagy; Myocardial ischemia/reperfusion injury