title: Synergestic effect of aqueous purslane (Portulaca oleracea L.) extract and fish oil on radiation-induced damage in rats.
abstract: OBJECTIVE
  To evaluate the impact of oral administration of purslane (Portulaca oleracea) extract or fish oil and their co-treatments in the modulation of radiation-induced damage.
  
  
  METHODS
  Purslane (P) (400 mg/kg body weight) or fish oil (Fo) (60 mg/kg body weight) was administrated to male albino rats via gastric intubation for 15 days after whole body exposure to a single dose of 6 Gy gamma rays. The animals were sacrificed after the elapse of 15 days.
  
  
  RESULTS
  The results revealed that irradiation induced a significant elevation of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c), and atherogenic index: TC/high density lipoprotein cholesterol (HDL-c) in addition to aspartate and alanine transaminase (AST, ALT), alkaline phophatase (ALP), bilirubin, as well as urea, creatinine and uric acid. Moreover, liver, kidney and heart malondialdehyde (MDA) was significantly elevated, whereas nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT) and HDL-c were depressed. Purslane and/or fish oil treatment significantly attenuated lipids alteration, liver and kidney functions as well as oxidative stress in irradiated rats. The results pointed out that dietary fish oil supplementation, at adequate doses, may provide a cushion for a prolonged therapeutic option against radiation-induced damage without harmful side-effects.
  
  
  CONCLUSIONS
  It could be concluded that purslane extract and fish oil may have therapeutic potential to improve hepatic and renal functions as well as oxidative stress in irradiated rats. Moreover, their co-administration showed a better improved liver function.
authors.affiliation: Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA) , Cairo , Egypt.
authors.forename: Afrag S H
authors.initials: AS
authors.lastname: Abd El-Azime
authors.forename: Elham M
authors.initials: EM
authors.lastname: Hussein
authors.forename: Omaima M
authors.initials: OM
authors.lastname: Ashry
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D004357:Drug Synergism; D005395:Fish Oils / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D010936:Plant Extracts / Q000494:pharmacology*; D031822:Portulaca / Q000737:chemistry*; D051381:Rats
chemical_list: D000924:Anticholesteremic Agents; D005395:Fish Oils; D010936:Plant Extracts
keywords: Purslane; fish oil; oxidative stress; γ-radiation