title: Successful treatment of pediatric histiocytic sarcoma using abbreviated high-risk leukemia chemotherapy.
abstract: Histiocytic sarcoma (HS) is a malignant tumor composed of proliferating cells of histiocytic origin. True HS is exceedingly rare, particularly in pediatric patients. These tumors are frequently aggressive, and outcome for patients with HS has traditionally been poor. There is currently no consensus on the optimal management of these tumors, with the literature consisting largely of case reports and small case series utilizing a wide variety of therapies. We describe a case of HS in an 8-year-old female who was successfully treated with an abbreviated leukemia chemotherapy regimen.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology-Oncology, Durham, North Carolina.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Heath
authors.forename: Shelly E
authors.initials: SE
authors.lastname: Burgett
authors.forename: Ana M
authors.initials: AM
authors.lastname: Gaca
authors.forename: Ronald
authors.initials: R
authors.lastname: Jaffe
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Wechsler
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy*; D006801:Humans; D015122:Mercaptopurine / Q000008:administration & dosage / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D012307:Risk Factors; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D015122:Mercaptopurine; D001215:Asparaginase; D011241:Prednisone; D008727:Methotrexate; D003630:Daunorubicin
keywords: histiocytic sarcoma; malignant histiocytosis; pediatric; true histiocytic lymphoma