title: Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection.
abstract: Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ-producing cells and the signals that regulate IFN-γ production during T. gondii infection.
authors.affiliation: Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Carolyn R
authors.initials: CR
authors.lastname: Sturge
authors.affiliation: Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA felix.yarovinsky@utsouthwestern.edu.
authors.forename: Felix
authors.initials: F
authors.lastname: Yarovinsky
mesh_terms: D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology*
chemical_list: D007371:Interferon-gamma