title: Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy.
abstract: Mitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tamura
authors.forename: Madhuparna
authors.initials: M
authors.lastname: Roy
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Adachi
authors.forename: Miho
authors.initials: M
authors.lastname: Iijima
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sesaki
mesh_terms: D000818:Animals; D003567:Cytidine Diphosphate Diglycerides / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics / Q000502:physiology*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D063306:Mitophagy / Q000502:physiology*; D010743:Phospholipids / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: D003567:Cytidine Diphosphate Diglycerides; D033681:Mitochondrial Membrane Transport Proteins; D010743:Phospholipids; D029701:Saccharomyces cerevisiae Proteins; D020558:GTP Phosphohydrolases; D034281:Dynamins