title: Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life.
abstract: Many cases of heritable environmental responses have been documented but the underlying mechanisms are largely unknown. Recently, inherited RNA interference has been shown to act as a multigenerational genome surveillance apparatus. We suggest that inheritance of regulatory RNAs is at the root of many other epigenetic phenomena, the trigger that induces other epigenetic mechanisms, such as the depositing of histone modifications and DNA methylation. In addition, we explore the possibility that interacting organisms influence each other's transcriptomes by exchanging heterologous non-coding RNAs.
authors.affiliation: Department of Neurobiology, Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 64332, Israel.
authors.forename: Mor
authors.initials: M
authors.lastname: Sela
authors.affiliation: Department of Neurobiology, Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 64332, Israel.
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kloog
authors.affiliation: Department of Neurobiology, Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 64332, Israel odedrechavi@gmail.com.
authors.forename: Oded
authors.initials: O
authors.lastname: Rechavi
mesh_terms: D000818:Animals; D005075:Biological Evolution; D044127:Epigenesis, Genetic / Q000502:physiology*; D010944:Plants; D011387:Prokaryotic Cells / Q000502:physiology*; D022661:RNA, Untranslated
chemical_list: D022661:RNA, Untranslated