title: Induction of systemic resistance against tobacco mosaic virus by Ningnanmycin in tobacco.
abstract: Ningnanmycin (NNM) is an antiviral agent firstly isolated from Strepcomces noursei var·xichangensisn. Studies have shown that NNM promotes PAL, POD and SOD activity and possesses antiviral activity against tobacco mosaic virus (TMV). In this study, our results demonstrated that NNM inhibited the polymerization process of TMV coat protein (TMV-CP) in vitro and promoted the systemic accumulation of pathogenesis-related proteins (PRs), which are the markers of systemic acquired resistance (SAR). An non-expressor, pathogenesis-related genes 1 (NPR1) that regulates SAR and induces systemic resistance (ISR), increased. In addition, the Jaz3 expression increase showed that NNM also induced ISR. Based on the results of this work and earlier reports, it is suggesting that NNM induces tobacco systemic resistance against TMV via activating multiple plant defense signaling pathways.
authors.affiliation: Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors.forename: Yongguang
authors.initials: Y
authors.lastname: Han
authors.affiliation: Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors.forename: Shirong
authors.initials: S
authors.lastname: Qin
authors.affiliation: Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xi
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wan
authors.affiliation: Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China. Electronic address: dulinfang@scu.edu.cn.
authors.forename: Linfang
authors.initials: L
authors.lastname: Du
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D036022:Capsid Proteins / Q000235:genetics / Q000378:metabolism; D003562:Cytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007113:Immunity, Innate; D010935:Plant Diseases / Q000276:immunology / Q000821:virology*; D010940:Plant Proteins / Q000235:genetics / Q000276:immunology; D014026:Nicotiana / Q000276:immunology* / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D036022:Capsid Proteins; D010940:Plant Proteins; C000594254:ningnanmycin; D003562:Cytidine
keywords: Induced systemic resistance; Ningnanmycin; Pathogenesis-related protein; Systemic acquired resistance; Tobacco mosaic virus