title: Canis lupus familiaris involved in the transmission of pathogenic Yersinia spp. in China.
abstract: To investigate canines carrying pathogens associated with human illness, we studied their roles in transmitting and maintaining pathogenic Yersinia spp. We examined different ecological landscapes in China for the distribution of pathogenic Yersinia spp. in Canis lupus familiaris, the domestic dog. The highest number of pathogenic Yersinia enterocolitica was shown from the tonsils (6.30%), followed by rectal swabs (3.63%) and feces (1.23%). Strains isolated from plague free areas for C. lupus familiaris, local pig and diarrhea patients shared the same pulsed-field gel electrophoresis (PFGE) pattern, indicating they may be from the same clone and the close transmission source of pathogenic Y. enterocolitica infections in these areas. Among 226 dogs serum samples collected from natural plague areas of Yersinia pestis in Gansu and Qinghai Provinces, 49 were positive for F1 antibody, while the serum samples collected from plague free areas were all negative, suggested a potential public health risk following exposure to dogs. No Y. enterocolitica or Yersinia pseudotuberculosis was isolated from canine rectal swabs in natural plague areas. Therefore, pathogenic Yersinia spp. may be regionally distributed in China.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Junrong
authors.initials: J
authors.lastname: Liang
authors.affiliation: Gansu Provincial Centre for Disease Control and Prevention, Lanzhou, China.
authors.forename: Jinxiao
authors.initials: J
authors.lastname: Xi
authors.affiliation: Xuzhou Municipal Centre for Disease Control and Prevention, Xuzhou, China.
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Yang
authors.affiliation: Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, China.
authors.forename: Mingliu
authors.initials: M
authors.lastname: Wang
authors.affiliation: Guizhou Provincial Centre for Disease Control and Prevention, Guiyang, China.
authors.forename: Kecheng
authors.initials: K
authors.lastname: Tian
authors.affiliation: Guizhou Provincial Centre for Disease Control and Prevention, Guiyang, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Li
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Qiu
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Duan
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Haoshu
authors.initials: H
authors.lastname: Yang
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Li
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Qinghai Institute for Endemic Diseases Control and Prevention, Xining, China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Qi
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China. Electronic address: jinghuaiqi@icdc.cn.
authors.forename: Huaiqi
authors.initials: H
authors.lastname: Jing
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology / Q000821:virology; D004285:Dogs; D016521:Electrophoresis, Gel, Pulsed-Field; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000821:virology; D013552:Swine; D015009:Yersinia Infections / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D015008:Yersinia enterocolitica / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*
chemical_list: D000914:Antibodies, Viral
keywords: Canine; Multi-host pathogens; Pathogenic Yersinia spp.; Pulsed-field gel electrophoresis; Zoonosis