title: Effects of percutaneous closure of atrial septal defect on left atrial mechanical and conduction functions.
abstract: OBJECTIVE
  Atrial septal defect (ASD) is one of the most common congenital heart diseases in adults. We prospectively evaluated early and mid-term effects of the percutaneous closure of secundum ASD on atrial electromechanical delay (AEMD) and left atrial (LA) mechanical functions at the first day and sixth month in patients undergoing percutaneous closure.
  
  
  RESULTS
  Forty-one patients were included in this study. Twenty-six (63.4%) of the 41 patients were female and the mean age was 41 ± 13 years. All the patients had echocardiographic examination before the procedure and at the first day and sixth month after the procedure. LA volumes (maximal, minimal, and presystolic) and EMD (lateral, septal, and tricuspid) were measured. Left and right intra- and inter-AEMD were not changed at the first day but both were significantly shorter at the sixth month. There was no change in the total emptying volume and fraction before and after the procedure. LA maximal, minimal, and pre-systolic volumes, active emptying volume, and fractions were decreased at the first day and at the sixth month compared with pre-procedural volumes. LA passive emptying volume, passive emptying fraction, and conduit volume were increased at the first day and at the sixth month compared with pre-procedural volumes.
  
  
  CONCLUSIONS
  Our results revealed that there was no change in the LA mechanical reservoir functions, but improved conduit function and impaired contractility functions early and in the mid-term after percutaneous closure of ASD and decreased AEMD only in the mid-term.
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Aslan
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey drerturk@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erturk
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Turen
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Uzun
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Surgit
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Sinem
authors.initials: S
authors.lastname: Ozbay Ozyilmaz
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Rifat Yildirim
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Faruk Baycan
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Begum
authors.initials: B
authors.lastname: Uygur
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, 34303 Istanbul, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Eksik
mesh_terms: D000328:Adult; D016279:Atrial Function, Left / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: atrial electromechanical delay; left atrial mechanical function; percutaneous closure; secundum atrial septal defect