title: Dezocine pretreatment prevents myoclonus induced by etomidate: a randomized, double-blinded controlled trial.
abstract: The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dezocine on the incidence and severity of myoclonus induced by etomidate. Patients (108) were randomly assigned to one of two groups to receive either 0.1 mg kg(-1) of dezocine (n = 54; Group D) or saline (n = 54; Group S) intravenously 1 min before 0.3 mg kg(-1) etomidate was given. The occurrence and severity (observational score of 0-3) of myoclonus was assessed for 2 min after administration of etomidate. The incidence and the intensity of myoclonus were significantly lower in Group D (0 %) than in Group S (75.9 %) (P < 0.01), and all patients showed stable cardiovascular profiles. The results suggest that infusion of 0.1 mg kg(-1) dezocine 1 min before etomidate administration is effective for suppressing myoclonus induced by etomidate during induction of general anesthesia without significant side-effects.
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
authors.forename: Liang
authors.initials: L
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Ding
authors.forename: Huiyu
authors.initials: H
authors.lastname: Chen
authors.forename: Yanning
authors.initials: Y
authors.lastname: Qian
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D000768:Anesthesia, General; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005045:Etomidate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D015994:Incidence; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced* / Q000517:prevention & control*; D013764:Tetrahydronaphthalenes / Q000009:adverse effects / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D019086:Bridged Bicyclo Compounds, Heterocyclic; D006993:Hypnotics and Sedatives; D013764:Tetrahydronaphthalenes; C010827:dezocine; D005045:Etomidate