title: Curcumin- and natural extract-loaded nanofibres for potential treatment of lung and breast cancer: in vitro efficacy evaluation.
abstract: Drug-eluting medical implants are more common, particularly for fighting against cancers. FDA and other drug regulatory bodies have approved many nanoformulated devices eluting active pharmaceutical ingredients and thus there is growing demand for further value- added devices. Nanofibre membranes are known for its versatility of drug incorporation and sustained drug release. We intend to fabricate natural ingredient or extract, and their combination loaded polycaprolactone (PCL) nanofibre for usage as drug-eluting stents or implants for anticancer activity against lung and breast cancers. The fabricated nanofibre membranes were characterised by scanning electron microscope for morphology, FT-IR for chemical nature and tensile testing for mechanical strengths. Release of curcumin was studied with time to find the applicability of the device as drug-eluting implant. The activity of the nanofibre membranes was tested against human breast cancer (MCF7) and lung cancer (A459) cell lines in vitro. In both the cell lines tested, 1% aloe vera and 5% curcumin-loaded PCL nanofibre exhibited 15% more cytotoxicity in comparison with the commercial drug 1% cis-Platin-loaded PCL nanofibre after 24 h incubation.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Sridhar
authors.forename: Swamy
authors.initials: S
authors.lastname: Ravanan
authors.forename: Jayarama Reddy
authors.initials: JR
authors.lastname: Venugopal
authors.forename: Subramanian
authors.initials: S
authors.lastname: Sundarrajan
authors.forename: Damian
authors.initials: D
authors.lastname: Pliszka
authors.forename: S
authors.initials: S
authors.lastname: Sivasubramanian
authors.forename: P
authors.initials: P
authors.lastname: Gunasekaran
authors.forename: Mohana
authors.initials: M
authors.lastname: Prabhakaran
authors.forename: Kalaipriya
authors.initials: K
authors.lastname: Madhaiyan
authors.forename: Arockia
authors.initials: A
authors.lastname: Sahayaraj
authors.forename: Keith Hsiu Chin
authors.initials: KH
authors.lastname: Lim
authors.forename: Seeram
authors.initials: S
authors.lastname: Ramakrishna
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D057139:Nanofibers / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010936:Plant Extracts; D011091:Polyesters; C016240:polycaprolactone; D003474:Curcumin
keywords: Nanofibre; PCL; anti-cancer; drug delivery; natural ingredient