title: A mammary adenocarcinoma murine model suitable for the study of cancer immunoediting.
abstract: BACKGROUND
  Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. Animal models are useful tools for studying diseases such as cancer. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi- and CBi/L inbred mice lines.
  
  
  RESULTS
  The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. CBi/L and CBi- mice were artificially selected for body conformation from CBi. When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi- the tumor growths briefly and then begins a rejection process in 100% of the animals. In CBi/L the growth of the tumor shows the three phases: 51.6% in ES, 18.5% in EQ and 29.8% in EL.
  
  
  CONCLUSIONS
  The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi- and CBi/L, is a good murine model to study the process of tumor immunoediting.
authors.forename: Lucas
authors.initials: L
authors.lastname: Pagura
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Cáceres
authors.forename: Albertina
authors.initials: A
authors.lastname: Cardinale
authors.forename: Olga Graciela
authors.initials: OG
authors.lastname: Scharovsky
authors.forename: Ricardo José Di
authors.initials: RJ
authors.lastname: Masso
authors.forename: Mariano Federico
authors.initials: MF
authors.lastname: Zacarías-Fluck
authors.forename: María José
authors.initials: MJ
authors.lastname: Rico
authors.affiliation: Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, (2000) Rosario, Argentina. viviana.rozados@gmail.com.
authors.forename: Viviana Rosa
authors.initials: VR
authors.lastname: Rozados
mesh_terms: D000230:Adenocarcinoma; D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D008325:Mammary Neoplasms, Experimental; D051379:Mice; D008954:Models, Biological