title: ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells.
abstract: One of the pathological characterizations of Alzheimer's disease (AD) is the deposition of amyloid beta peptide (Abeta) in cerebral cortical cells. The deposition of Abeta in neuronal cells leads to an increase in the production of free radicals that are typified by reactive oxygen species (ROS), thereby inducing cell death. A growing body of evidence now suggests that several plant-derived food ingredients are capable of scavenging ROS in mammalian cells. The purpose of the present study was to investigate whether enzyme-treated asparagus extract (ETAS), which is rich in antioxidants, is one of these ingredients. The pre-incubation of differentiated PC 12 cells with ETAS significantly recovered Abeta-induced reduction of cell viability, which was accompanied by reduced levels of ROS. These results suggest that ETAS may be one of the functional food ingredients with anti-oxidative capacity to help prevent AD.
authors.forename: Junetsu
authors.initials: J
authors.lastname: Ogasawara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Wakame
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kitadate
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakurai
authors.forename: Shogo
authors.initials: S
authors.lastname: Sato
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Izawa
authors.forename: Kazuto
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishida
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takabatake
authors.forename: Takako
authors.initials: T
authors.lastname: Kizaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohno
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D027761:Asparagus Plant / Q000737:chemistry*; D002470:Cell Survival; D005609:Free Radicals / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D005609:Free Radicals; D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase