title: Assessment of angiotensin I metabolism in the human placenta using an LC/MS method.
abstract: The local renin-angiotensin system (RAS) in the placenta plays a very important role in placental development. It is well known that during normal pregnancy most of the circulating and local RAS components are over-expressed and any disruption of this new balance may cause pregnancy complications. The aim of this study was to assess the metabolism of Ang I in placentas from normal pregnancy, in an ex vivo model, using an LC/MS method. The obtained results suggest that placental tissue is able to produce many angiotensin peptides but the main metabolite is Ang-(1-7).
authors.affiliation: Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Stettner
authors.affiliation: Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland. beata.bujak-gizycka@uj.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Bujak-Gizycka
authors.affiliation: Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Rafal
authors.initials: R
authors.lastname: Olszanecki
authors.affiliation: Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rytlewski
authors.affiliation: Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Hubert
authors.initials: H
authors.lastname: Huras
authors.affiliation: Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Korbut
mesh_terms: D000803:Angiotensin I / Q000378:metabolism*; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D053858:Metabolic Networks and Pathways; D010446:Peptide Fragments / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7)