title: Anti-Angiotensin type 1 receptor antibodies in chronic graft-versus-host disease.
abstract: BACKGROUND
  Activating anti-angiotensin type 1 receptor antibodies (AT1R-AA) have been described in patients with systemic scleroderma, an auto-immune disorder with clinical fibrotic features. Chronic graft-versus-host disease (cGvHD) after hematopoietic stem cell transplantation may have clinical fibrotic features, whose pathogenesis may be similar with systemic sclerosis.
  
  
  OBJECTIVE
  To evaluate the presence of AT1R-AA and their association with clinical and biological symptoms in cGvHD patients.
  
  
  METHODS
  Sera from 87 patients including 45 extensive cGvHD and 42 hematopoietic stem cell transplantation patients without cGvHD were retrospectively analyzed for the presence of AT1R-AA using an enzymatic immunoassay.
  
  
  RESULTS
  The frequency of AT1R-AA was significantly increased (odds ratio [OR]=3.4, P=0.04) in the cGvHD group (24.4%) compared with the non-cGvHD group (7.1%). In the cGvHD group the positivity of AT1R-AA was significantly associated with: i/ the presence of antinuclear antibodies (OR=5.9, P=0.04) ii/ a more severe global and organ-specific cGvHD scoring (P<0.05), iii/ the presence of active skin or mucosal erosions (OR=19.2, P<0.01). There was no difference between the number and the types of organs involved by the cGvHD between the AT1R-AA-positive versus AT1R-AA-negative subgroups.
  
  
  CONCLUSIONS
  This preliminary study suggests a potential role and prognostic value of AT1R-AA in cGvHD.
authors.affiliation: 1 Université Paris Diderot, Sorbonne Paris Cité; AP-HP; Hôpital Saint Louis, Paris, France. 2 Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, Paris, France. 3 Service de Dermatologie, Hôpital Saint-Louis, Paris, France. 4 Laboratoire d'Immunologie, Dermatologie et Oncologie, Hôpital Saint-Louis, INSERM U976, Paris, France. 5 Service d'Hématologie-Greffe, Hôpital Saint-Louis, Paris, France. 6 Service de Pneumologie, Hôpital Saint-Louis, Paris, France. 7 INSERM U1160, Paris, France. 8 INSERM UMRS 940, Paris, France. 9 Laboratoire de Parasitologie, Hôpital Saint-Louis, Paris, France. 10 Address correspondence to: Andrada Chiron, M.D., Laboratoire d'Immunologie et d'Histocompatibilité. Hôpital Saint-Louis. 1 avenue Claude Vellefaux. 75010 Paris, France. 11 Address correspondence to: Gerard Socié, M.D., Ph.D., Service d'Hématologie-Greffe, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010 Paris, France.
authors.forename: Andrada
authors.initials: A
authors.lastname: Chiron
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Bouaziz
authors.forename: Maryvonnick
authors.initials: M
authors.lastname: Carmagnat
authors.forename: Régis
authors.initials: R
authors.lastname: Peffault de Latour
authors.forename: Anne
authors.initials: A
authors.lastname: Lafaurie-Bergeron
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.forename: Aliénor
authors.initials: A
authors.lastname: Xhaard
authors.forename: Antoine
authors.initials: A
authors.lastname: Toubert
authors.forename: Dominique
authors.initials: D
authors.lastname: Charron
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guigue
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
authors.forename: Djaouida
authors.initials: D
authors.lastname: Bengoufa
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1