title: Cucurbitacin-E inhibits multiple cancer cells proliferation through attenuation of Wnt/β-catenin signaling.
abstract: Recent studies suggest that the use of cucurbitacins could inhibit cancer cell progression. In the current study, the authors analyzed the effect of cucurbitacin-E (CuE) in cancer cells using A549, Hep3B, and SW480 cells. The authors found that CuE inhibited cell proliferation and modulated the expression of cell cycle regulators in these cells. Moreover, the authors found that CuE inhibited Wnt/β-catenin signaling activation through upregulation of tumor suppressor Menin. Indeed, ablation of Menin using small interfering RNA (siRNA) oligos attenuated the antiproliferative roles of CuE. Taken together, the results of this study provide a novel mechanism that may contribute to the antineoplastic effects of CuE in cancer cells.
authors.affiliation: 1 Combined Chinese and Western Medicine Division, The First Affiliated Hospital of Xinxiang Medical University , Xinxiang, China .
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
authors.forename: Li
authors.initials: L
authors.lastname: Zang
authors.forename: Zhen-Xia
authors.initials: ZX
authors.lastname: Zhao
authors.forename: Quan-Cheng
authors.initials: QC
authors.lastname: Kan
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014315:Triterpenes / Q000494:pharmacology*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C495270:CTNNB1 protein, human; D014315:Triterpenes; D051153:Wnt Proteins; D051176:beta Catenin; C102326:cucurbitacin E
keywords: Menin; Wnt/β-catenin signaling; cell proliferation; cucurbitacin-E