title: Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats.
abstract: BACKGROUND
  Depression and high-fat diet are both known as independent risk factors for atherosclerosis and other cardiovascular diseases, suggesting the interaction of psychological and physiological factors in the development of these diseases. The liver is a crucial organ that facilitate lipid metabolism especially in reverse cholesterol transport (RCT), while according to the theory of Traditional Chinese Medicine, depression as a kind of psychological stress has an influence on hepatic function. So there seem to be some links between depression and lipid metabolic disorders.
  
  
  METHODS
  To investigate these links, we separately treated rats with chronic unpredictable mild stress (CMS) and/or a high-fat diet (HD) to evaluate the development of atherosclerosis and the expression of hepatic ABCG8, ABCG5, SR-BI, CYP7A1, LXRα, and LCAT which were associated with reverse cholesterol transport.
  
  
  RESULTS
  This study provided evidence that high-fat diet greatly decreased these genes expression related to RCT while chronic stress alone tended to promote RCT. Chronic unpredictable mild stress combined with a high-fat diet attenuated RCT and aggravated atherogenesis.
  
  
  CONCLUSIONS
  These observations suggested that chronic psychological stress alone is virtually propitious to lipid metabolism, however when under a condition of high-fat diet, it deteriorated atherosclerotic plague and did harm to RCT.
authors.forename: Shuling
authors.initials: S
authors.lastname: Wang
authors.forename: Gao
authors.initials: G
authors.lastname: Xiaoling
authors.forename: Li
authors.initials: L
authors.lastname: Pingting
authors.forename: Liu
authors.initials: L
authors.lastname: Shuqiang
authors.affiliation: School of Chinese Herb Medicine, Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, 232 Waihuandong Road, Guangzhou 510006, China. zengyuaner@126.com.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Yuaner
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000473:pathology*; D001692:Biological Transport / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D002784:Cholesterol