title: CuI-catalyzed C-N bond formation and cleavage for the synthesis of benzimidazo[1,2-a]quinazoline derivatives.
abstract: A copper(I)-catalyzed domino reaction of N-(2-benzimidazolyl)-2-aminobenzamide and 2-halogenated benzaldehyde has been studied. The procedure is based on a sequential CuI-catalyzed Ullmann reaction (C-N bond formation) and two bond cleavage reactions and provides an efficient strategy for the synthesis of benzimidazo[1,2-a]quinazolines catalyzed by CuI/L-proline.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University , Xuzhou, Jiangsu 221116, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Zhang
authors.forename: Xiang-Shan
authors.initials: XS
authors.lastname: Wang
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D001549:Benzamides / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001547:Benzaldehydes; D001549:Benzamides; D001562:Benzimidazoles; D006846:Hydrocarbons, Halogenated; C000593451:N-(2-benzimidazolyl)-2-aminobenzamide; D011799:Quinazolines; C000593450:benzimidazo(1,2-a)quinazoline; D003300:Copper; D011392:Proline