title: Alpha-1 adrenergic antagonists induced severe rhinitis in patients with benign prostatic hyperplasia.
abstract: The standard gold care medications for benign prostatic hyperplasia (BPH) are the alpha-1-adrenergic antagonists, they are an effective medications and are generally well tolerated. However, at this time, no data have been published concerning the development of severe rhinorrhea with a great impact on quality of life in patients treated with alpha-1-adrenergic antagonists. We report two men with BPH treated with two different alpha-adrenergic antagonists; alfuzosin and doxazocin. The naranjo quality scale documented a probable adverse drug reaction (score 7) between rhinorrhea and treatment with alpha-1-adrenergic antagonists. In conclusion we reported that alpha-1-adrenergic antagonists are able to induce rhinorrhea in patients with BPH.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Shahar
authors.forename: Laila
authors.initials: L
authors.lastname: Nassar
authors.forename: Eynat
authors.initials: E
authors.lastname: Kedem
authors.affiliation: Institute of Allergy, Clinical Immunology & AIDS, Rambam Health Care Campus, Israel. ed_shahar@rambam.health.gov.il.
authors.forename: Gammal
authors.initials: G
authors.lastname: Hassoun
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D000368:Aged; D002559:Cerebrospinal Fluid Rhinorrhea / Q000139:chemically induced; D017292:Doxazosin / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011799:Quinazolines / Q000009:adverse effects; D012220:Rhinitis / Q000139:chemically induced*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D011799:Quinazolines; C047638:alfuzosin; D017292:Doxazosin