title: Rectal route in the 21st Century to treat children.
abstract: The rectal route can be considered a good alternative to the oral route for the paediatric population because these dosage forms are neither to be swallowed nor need to be taste-masked. Rectal forms can also be administered in an emergency to unconscious or vomiting children. Their manufacturing cost is low with excipients generally regarded as safe. Some new formulation strategies, including mucoadhesive gels and suppositories, were introduced to increase patient acceptability. Even if recent paediatric clinical studies have demonstrated the equivalence of the rectal route with others, in order to enable the use of this promising route for the treatment of children in the 21st Century, some effort should be focused on informing and educating parents and care givers. This review is the first ever to address all the aforementioned items, and to list all drugs used in paediatric rectal forms in literature and marketed products in developed countries.
authors.affiliation: Gattefossé S.A.S., 36 chemin de Genas, 69804 Saint-Priest cedex, France. Electronic address: vjannin@gattefosse.com.
authors.forename: Vincent
authors.initials: V
authors.lastname: Jannin
authors.affiliation: Université Bordeaux Segalen, LTPIB UFR Pharmacie, 146 rue Leo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemagnen
authors.affiliation: Université Bordeaux Segalen, LTPIB UFR Pharmacie, 146 rue Leo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Gueroult
authors.affiliation: Université Bordeaux Segalen, LTPIB UFR Pharmacie, 146 rue Leo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Larrouture
authors.affiliation: UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuleu
mesh_terms: D000285:Administration, Rectal; D002648:Child; D006801:Humans; D010372:Pediatrics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations
keywords: Hard fat; Malaria; Market; Paediatric; Patient-centred drug delivery; Suppository