title: Mass spectrometry-based tag and its application to high efficient peptide analysis - A review.
abstract: Chemical derivatization is a very promising technique for improving analysis of peptides by mass spectrometry (MS). Thereinto, development of novel tags compatible with MS and/or MS/MS has always been the focus point of study. In this review, the recent reported tags for derivatization of thiol groups of cysteine, carboxyl groups, and amino groups on peptides as well as peptides with post-translational modifications (PTMs) are summarized. Moreover, the tags used for derivatization of glycans or oligosaccharides released from glycoproteins are also reviewed.
authors.affiliation: Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China. Electronic address: xiaoqiao@hbu.edu.cn.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Qiao
authors.affiliation: College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Qin
authors.affiliation: Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: She
authors.affiliation: Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address: lihuazhang@dicp.ac.cn.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Yukui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D003545:Cysteine / Q000737:chemistry / Q000378:metabolism; D006023:Glycoproteins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D006023:Glycoproteins; D009844:Oligosaccharides; D010455:Peptides; D011134:Polysaccharides; D003545:Cysteine
keywords: High efficient analysis; Mass spectrometry; Peptide; Tag