title: MicroRNA and gynecological reproductive diseases.
abstract: MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gynecological diseases, cancer, inflammatory diseases, and cardiovascular disorders. Abnormal expression of miRNAs has been observed in multiple human reproductive tract diseases including preeclampsia, endometrioid endometrial adenocarcinoma, uterine leiomyomata, ovarian carcinoma, endometriosis, and recurrent pregnancy loss. In the following review, an update of the role of microRNA and gynecological diseases is performed covering, not only impact of microRNA dysregulation in the origin of each disease, but also showing the potential useful diagnostic and therapeutic tool that miRNA may play in these gynecological pathologies.
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano Infertilidad (IVI) Barcelona, Barcelona, Spain. Electronic address: xavier.santamaria@ivi.es.
authors.forename: Xavier
authors.initials: X
authors.lastname: Santamaria
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Hugh
authors.initials: H
authors.lastname: Taylor
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D004715:Endometriosis / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation; D005819:Genetic Markers; D005831:Genital Diseases, Female / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007889:Leiomyoma / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D035683:MicroRNAs / Q000378:metabolism*; D011247:Pregnancy; D012098:Reproduction / Q000235:genetics; D015398:Signal Transduction; D014594:Uterine Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs
keywords: MicroRNA; endometriosis; leiomyoma; ovarian endometriosis; peritoneal endometriosis; recurrent pregnancy loss; single nucleotide polymorphisms