title: Magnetic resonance imaging in the tibial epiphyseal growth plate development of Wistar rat.
abstract: OBJECTIVE
  This research aims to investigate magnetic resonance imaging (MRI) in the tibial epiphyseal growth plate development of Wistar rat.
  
  
  METHODS
  Fifty weanling Wistar rats were divided by a computerized blocking procedure into five groups. The rats received standard commercial feed with or without T-2 toxin additive, low-protein feed with or without T-2 toxin additive, and Kashin-Beck disease (KBD)-affected feed.
  
  
  RESULTS
  Compared with the control group rat, MRI showed localized epiphyseal plate swelling, rough appearance, and uneven signal on the tibia of rats fed with KBD-affected feed. Histology confirmed the epiphyseal plate degeneration seen by MRI, and the degenerative changes were characterized by abnormal distribution of chondrocytes with loss and clustering, cartilage fragmentation, and erosion in group E.
  
  
  CONCLUSIONS
  The MR image of the rat epiphyseal plate is altered in the KBD model rats, and epiphyseal plate MRI appearance has been reproduced by using T-2 toxin and KBD-affected feed of epidemic district.
authors.forename: Denglu
authors.initials: D
authors.lastname: Yan
authors.forename: Yancheng
authors.initials: Y
authors.lastname: Song
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.forename: Pengde
authors.initials: P
authors.lastname: Kang
authors.affiliation: West China Hospital, Sichuan University, Chengdu 610065, People's Republic of China. peifuxing@126.com.
authors.forename: Fuxing
authors.initials: F
authors.lastname: Pei
mesh_terms: D000818:Animals; D001846:Bone Development; D016022:Case-Control Studies; D019902:Chondrocytes / Q000473:pathology*; D004195:Disease Models, Animal; D004838:Epiphyses / Q000473:pathology; D005260:Female; D006132:Growth Plate / Q000254:growth & development / Q000473:pathology*; D057767:Kashin-Beck Disease / Q000139:chemically induced / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013605:T-2 Toxin / Q000633:toxicity; D013977:Tibia / Q000473:pathology*
chemical_list: D013605:T-2 Toxin