title: Development and characterization of spray-dried porous nanoaggregates for pulmonary delivery of anti-tubercular drugs.
abstract: Tuberculosis, MTB or tubercle bacillus (TB) is a lethal, infectious disease mainly caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. In this study, guar gum-based porous nanoaggregates were formulated by precipitation technique with two frontline antitubercular drugs, i.e. isoniazid and rifampicin. The formulations were optimized on the basis of various evaluation parameters such as morphology, density, entrapment efficiency and in vitro drug release. The optimized formulations were administered by inhalable route to Wistar rats for the evaluation of drugs in different organs (lungs, liver and kidneys). High drug encapsulation efficiency was achieved in guar gum porous nanoaggregates, ranging from 50% to 60%. A single pulmonary dose resulted in therapeutic drug concentrations of 30%-50% in the lungs and in other organs (less than 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs. Furthermore, the formulation showed sustained drug release pattern, which could be beneficial for reducing the drug dose or frequency of dosing, thus helpful in improving patient compliance.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India and.
authors.forename: Ranjot
authors.initials: R
authors.lastname: Kaur
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India and.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India and.
authors.forename: Basant
authors.initials: B
authors.lastname: Malik
authors.affiliation: b National jalma institute for leprosy and other mycobacterial diseases , Agra , UP , India.
authors.forename: Umesh Datta
authors.initials: UD
authors.lastname: Gupta
authors.affiliation: b National jalma institute for leprosy and other mycobacterial diseases , Agra , UP , India.
authors.forename: Pushpa
authors.initials: P
authors.lastname: Gupta
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India and.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India and.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Goyal
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D005685:Galactans / Q000737:chemistry; D007538:Isoniazid / Q000008:administration & dosage / Q000737:chemistry; D008168:Lung / Q000187:drug effects*; D008297:Male; D008351:Mannans / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000008:administration & dosage / Q000737:chemistry; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D007538:Isoniazid; D012293:Rifampin
keywords: Nanoaggregate; patient compliance; pulmonary route; sustained release; tuberculosis