title: Significance of viral status on occurrence of hepatitis B-related hepatocellular carcinoma.
abstract: Hepatitis B virus (HBV) infection remains a challenging global health problem, with more than 350 million people chronically infected and at risk of developing hepatocellular carcinoma (HCC). Interactions that occur among host, environmental, and viral factors determine the natural course and predict the prognosis of patients with chronic HBV infection. In the past decades, several important viral factors of predictive of HCC have been identified, such as high hepatitis B surface antigen level, seropositivity of hepatitis B e antigen, high viral load, viral genotype, and specific viral sequence mutations. Identification of certain viral risk factors for HCC development and stratification of patient risk are very important to perform future surveillance programs. In this article, we thus reviewed the risk of viral factors involved in hepatocarcinogenesis.
authors.affiliation: Li-Shuai Qu, Guo-Xiong Zhou, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Li-Shuai
authors.initials: LS
authors.lastname: Qu
authors.affiliation: Li-Shuai Qu, Guo-Xiong Zhou, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Guo-Xiong
authors.initials: GX
authors.lastname: Zhou
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000821:virology*; D004279:DNA, Viral / Q000097:blood; D005838:Genotype; D006514:Hepatitis B Surface Antigens / Q000235:genetics; D006513:Hepatitis B e Antigens / Q000235:genetics; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000821:virology*; D009154:Mutation; D012307:Risk Factors; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
keywords: Genotype; Hepatitis B virus; Hepatocellular carcinoma; Mutation; Serum hepatitis B virus-DNA levels