title: Complement the hemostatic system: an intimate relationship.
abstract: The complement system is important part of our innate immune system and interacts directly with the hemostatic system. Disorders of complement activation or dysregulation resulting in excess complement generation, such as Paroxysmal Nocturnal Hemoglobinuria (PNH), atypical Hemolytic uremic Syndrome (aHUS) and antiphospholipid syndrome (APLS) have been associated with significant thrombophilia. Terminal Complement (C5b-9) deposition on endothelial and tumor cell membranes has also been reported in a variety of cancer. Recent developments in complement inhibition have given us new insights into the mechanism of thrombosis in these disorders.
authors.affiliation: Associate Clinical Professor of Medicine, Jane Anne Nohl Division of Hematology, Keck- USC School of Medicine, Los Angeles, CA , United States. Electronic address: iweitz@med.usc.edu.
authors.forename: Ilene Ceil
authors.initials: IC
authors.lastname: Weitz
mesh_terms: D003165:Complement System Proteins / Q000276:immunology*; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000276:immunology*; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000276:immunology*; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000276:immunology*; D013927:Thrombosis / Q000097:blood / Q000276:immunology*
chemical_list: D003165:Complement System Proteins
keywords: Cancer; Complement; PNH; TMA; Thrombosis