title: [Intervention effect of probiotic bifidobacterium on type 2 diabetes mellitus rats].
abstract: OBJECTIVE
  To observe the influences of bifidobacterium on glucose and lipid metabolism and intestinal flora in type 2 diabetes mellitus rats.
  
  
  METHODS
  Rats were randomly divided into 4 groups, the blank control group was fed with basic forage, the other 3 groups were fed with high fat diet. Meanwhile the high-dose and low-dose groups were gavage administrated with 12 and 4 ml/(kg x d) probiotic bifidobacterium for 6 weeks, then, injected with low dose of streptozotocin (20 mg/kg). All rats were sacrificed 2 weeks later, blood and feces samples were collected to analyse.
  
  
  RESULTS
  Compared with rats of type 2 diabetes model, glucose concentrations and serum concentrations of FFA, TG, LDL-C of 2 experimental groups were significantly lower, serum concentrations of HDL-C were higher, insulin sensitivity index was higher, content of bifidobacterium was higher, but there were no significant differences in other 5 bacteria.
  
  
  CONCLUSIONS
  The probiotic bifidobacterium could significantly ameliorate the disorder of glucose and lipid metabolism, increase the amount of bifidobacterium of type 2 diabetes rats.
authors.forename: Zongkai
authors.initials: Z
authors.lastname: Xu
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Ruirui
authors.initials: R
authors.lastname: Dai
authors.forename: Jingye
authors.initials: J
authors.lastname: Shang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000818:Animals; D001644:Bifidobacterium; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2; D059305:Diet, High-Fat; D007328:Insulin; D007333:Insulin Resistance; D050356:Lipid Metabolism; D019936:Probiotics / Q000494:pharmacology*; D051381:Rats; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin