title: Metastatic Crohn's disease: a review and approach to therapy.
abstract: Metastatic Crohn's disease (CD) is a rare cutaneous manifestation of CD that was first described nearly 50 years ago. Many subsequent reports have defined its most common clinical and histopathologic features. The pathogenesis underlying metastatic CD is unknown but various hypotheses exist. An established standard therapy is lacking. Owing to its rarity and nonspecific clinical presentation along with the diversity of inflammatory skin disorders that often complicate CD, the diagnosis of metastatic CD may be overlooked. This report highlights the salient features of this disorder to facilitate recognition and management of this rare dermatosis.
authors.affiliation: Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona. Electronic address: kurtzman@email.arizona.edu.
authors.forename: Drew J B
authors.initials: DJ
authors.lastname: Kurtzman
authors.affiliation: Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.
authors.forename: Trevor
authors.initials: T
authors.lastname: Jones
authors.affiliation: Department of Pathology, University of Arizona College of Medicine, Tucson, Arizona.
authors.forename: Fangru
authors.initials: F
authors.lastname: Lian
authors.affiliation: Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.
authors.forename: Lisan S
authors.initials: LS
authors.lastname: Peng
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001707:Biopsy, Needle; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology*; D003879:Dermatologic Agents / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011379:Prognosis; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents
keywords: cutaneous Crohn's disease; cutaneous manifestations of Crohn's disease; gastrointestinal disease; granulomatous inflammation; inflammatory bowel disease; metastatic Crohn's disease