title: Association of vitamin D receptor gene polymorphism with the risk of lung cancer: a meta-analysis.
abstract: Relationship between vitamin D receptor (VDR) gene polymorphism and the risk of lung cancer from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR TaqI (rs731236), BsmI (rs1544410) and ApaI (rs7975232) gene polymorphism and the risk of lung cancer using meta-analysis method. The association studies were identified from PubMed and Cochrane Library on 1 December 2013, and eligible investigations were included and synthesized using meta-analysis method. Six reports were recruited into this meta-analysis for the association of VDR gene polymorphism with lung cancer susceptibility. In the meta-analysis for ApaI gene polymorphism, AA genotype was associated with the risk of lung cancer in Asians. In the meta-analysis for BsmI gene polymorphism, B allele, BB genotype and bb genotype were associated with lung cancer in Asians, and B allele bb genotype were associated with lung cancer risk in overall populations; furthermore, bb genotype was associated with lung cancer risk in Caucasians. In the meta-analysis for TaqI gene polymorphism, t allele and TT genotype were associated with lung cancer in overall populations and in Caucasians. In conclusion, B allele bb genotype t allele and TT genotype were associated with lung cancer risk in overall populations. AA genotype, B allele, BB genotype and bb genotype were associated with the risk of lung cancer in Asians. Furthermore, bb genotype t allele and TT genotype was associated with lung cancer risk in Caucasians. However, more studies should be conducted to confirm it.
authors.affiliation: Department of Cardio-Thoracic Surgery, People's Hospital of Beihai , BeiHai , China and.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhong
authors.forename: Rang
authors.initials: R
authors.lastname: Zhou
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Gui-Xiong
authors.initials: GX
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Jun-Yuan
authors.initials: JY
authors.lastname: Zhang
authors.forename: Xing-Qiang
authors.initials: XQ
authors.lastname: Qin
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Ji-Qi
authors.initials: JQ
authors.lastname: Wu
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Zhong
mesh_terms: D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D005819:Genetic Markers; D018167:Receptors, Calcitriol
keywords: Gene polymorphism; lung cancer; meta-analysis; vitamin D receptor