title: Perioperative blood transfusion adversely affects prognosis after resection of lung cancer: a systematic review and a meta-analysis.
abstract: BACKGROUND
  It is speculated that blood transfusion may induce adverse consequences after cancer surgery due to immunosuppression. This study was intended to assess the impact of perioperative blood transfusion on the prognosis of patients who underwent lung cancer resection.
  
  
  METHODS
  Eligible studies were identified through a computerized literature search. The pooled relative risk ratio (RR) with 95% confidence interval (CI) was calculated using Review Manager 5.1 Software.
  
  
  RESULTS
  Eighteen studies with a total of 5915 participants were included for this meta-analysis. Pooled analysis showed that perioperative blood transfusion was associated with worse overall survival (RR: 1.25, 95% CI: 1.13-1.38; P <0.001) and recurrence-free survival (RR: 1.42, 95% CI: 1.20-1.67; P <0.001) in patients with resected lung cancer.
  
  
  CONCLUSIONS
  Perioperative blood transfusion appears be associated with a worse prognosis in patients undergoing lung cancer resection. These data highlight the importance of minimizing blood transfusion during surgery.
authors.forename: Haixing
authors.initials: H
authors.lastname: Luan
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Lupeng
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, Oncologic Center of Xiamen; First affiliated Hospital of Xiamen University, Xiamen 361003, China. zhouymsxy@sina.cn.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
mesh_terms: D016001:Confidence Intervals; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D015233:Models, Statistical; D016017:Odds Ratio; D019990:Perioperative Care / Q000009:adverse effects*; D011013:Pneumonectomy; D011379:Prognosis; D015996:Survival Rate; D065227:Transfusion Reaction