title: P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran.
abstract: OBJECTIVE
  Squamous cell carcinoma is the most common cancer of the oral cavity, and several etiologic factors are involved in its developing. Single nucleotide polymorphism (SNP) of the P53 gene codon 72 (P53c72) changes the structure of the protein and affects its activity. The prevalence of P53c72 different genotypes, which seems to vary with race and geographic location, has shown a strong correlation with many types of human cancers. The aim of this study was to investigate the correlation between P53c72polymorphism and risk of oral squamous cell carcinoma (OSCC) in the heavily populated Gilan Province in northern Iran.
  
  
  METHODS
  This case-control study was done on 55 paraffin-embedded samples from OSCC patients and 100 samples of non-dysplastic oral cavity lesions. The P53c72 genotypes were determined using the ARMS-PCR method. SPSS-15 software was used for statistical analysis.
  
  
  RESULTS
  There were no significant statistical differences found between the prevalence of different P53c72 genotypes in the OSCC group vs. the control. However, the Pro/Pro genotype in OSCC samples showed a strong correlation with age, as 70% of such patients were below 50 years old. Interestingly, a large portion (40%) of the patients with the Pro/Pro genotype had the tumor in the lip area.
  
  
  CONCLUSIONS
  Although P53c72 polymorphism does not appear to be a predisposing factor for OSCC in the population of Northern Iran, the Pro/Pro genotype could be considered as a risk factor for OSCC in adults below 50 years old and the anatomical location of the tumor.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, TBZMED, Tabriz, Iran, pathologist1357@yahoo.com.
authors.forename: Mahmud
authors.initials: M
authors.lastname: Sina
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Pedram
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazadeh
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kochaki
authors.forename: Amirala
authors.initials: A
authors.lastname: Aghbali
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D003062:Codon