title: Balloon-occluded retrograde transvenous obliteration versus endoscopic injection sclerotherapy for isolated gastric varices: a comparative study.
abstract: Isolated gastric varices (IGV) have a lower risk of bleeding than esophageal varices, however IGV bleeding is associated with a higher mortality than bleeding of esophageal varices. In recent years, two widely used treatments for IGV have been balloon-occluded retrograde transvenous obliteration (B-RTO) and endoscopic injection sclerotherapy (EIS) using cyanoacrylate or ethanolamine oleate (EO). This study compared these two treatment methods for IGV. The subjects were 112 patients who were treated at our hospital for IGV bleeding between October 1990 and December 2003. Forty-nine (49) patients were treated with B-RTO and 63 patients with EIS. These two patient groups were compared as regards content of treatment, post-treatment incidence of variceal bleeding, incidence of IGV rebleeding, survival rate, cause of death, and complications. Multivariate analysis was performed on post-treatment variceal bleeding and survival. Although EO was used in higher amounts in the B-RTO group than in the EIS group, the B-RTO group had a significantly lower number of treatment sessions and a significantly shorter treatment period (p<0.05). The EIS group had significantly more patients with IGV rebleeding after treatment than the B-RTO group. Treatment method was the only independent prognostic factor of IGV bleeding after treatment (p=0.024). The two groups did not differ significantly in the percentage of patients with aggravated esophageal varices after treatment. Bleeding from ectopic varices was not observed in any patient. There was no significant difference in survival by treatment method. The presence of hepatocellular carcinoma was the only independent prognostic factor for survival (p=0.003). It is concluded that B-RTO was more effective than EIS in the eradication of IGV and prevention of IGV recurrence and rebleeding.
authors.affiliation: Department of Medicine, Kurume University School of Medicine.
authors.forename: Keigo
authors.initials: K
authors.lastname: Emori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toyonaga
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Oho
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kumamoto
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Haruta
authors.forename: Hiroto
authors.initials: H
authors.lastname: Inoue
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Morita
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mitsuyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Tsuruta
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D000368:Aged; D021721:Balloon Occlusion / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D003487:Cyanoacrylates / Q000008:administration & dosage; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D005773:Gastroscopy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006801:Humans; D007267:Injections; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009829:Oleic Acids / Q000008:administration & dosage; D016016:Proportional Hazards Models; D012008:Recurrence; D012307:Risk Factors; D012597:Sclerosing Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D015911:Sclerotherapy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003487:Cyanoacrylates; D009829:Oleic Acids; D012597:Sclerosing Solutions; C033343:ethanolamine oleate