title: A new Lycopodium alkaloid from Phlegmariurus fargesii.
abstract: OBJECTIVE
  To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii.
  
  
  METHODS
  Compounds were isolated by repeated silica gel column chromatography. Their structures were elucidated by spectroscopic methods and chemical correlation. The acetylcholinesterase (AChE) inhibitory activity of the isolated compounds was evaluated.
  
  
  RESULTS
  A new Lycopodium alkaloid, lycopodine N-oxide (1), along with lycopodine (2), 8,15-dehydrolycopodine (3), 6α-hydroxylycopodine (4), deacetyllycoclavine (5), N-methylhuperzine B (6), lycodine (7), and phlegmarine (8), was isolated.
  
  
  CONCLUSIONS
  Compound 1 is a new Lycopodium alkaloid, and compound 3 was obtained from nature for the first time. Other alkaloids are isolated from this plant for the first time.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D032501:Huperzia / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D011807:Quinolizines / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D011807:Quinolizines; C016542:lycopodine
keywords: Lycopodine N-oxide; Lycopodium alkaloids; Phlegmariurus fargesii