title: Serum apolipoprotein B-48 concentration is associated with a reduced estimated glomerular filtration rate and increased proteinuria.
abstract: OBJECTIVE
  Apolipoprotein B-48 (apoB-48) is a constituent of chylomicrons and their remnants (chylomicron remnants). A high concentration of serum apoB-48 is suspected to be a major risk factor for the development of atherosclerotic cardiovascular disease. Proteinuria and a reduced estimated glomerular filtration rate (eGFR) are independent risk factors for cardiovascular events and renal dysfunction. In the present study, we examined whether the serum apoB-48 concentration is associated with renal dysfunction.
  
  
  METHODS
  A total of 264 patients was enrolled and classified into four groups according to the eGFR and level of proteinuria: a high eGFR (＞60mL/min/1.73m(2)) without proteinuria (≥1＋ by urine dipstick) (n=50); a high eGFR with proteinuria (n=75); a low eGFR (＞60mL/min/1.73m(2)) without proteinuria (n=74); and a low eGFR with proteinuria (n=65). Biochemical markers of lipid metabolism, including the fasting serum apoB-48 concentration, were compared between the four groups.
  
  
  RESULTS
  The serum log-apoB-48 and log-apoB-48/TG levels were significantly higher in the patients with a high eGFR with proteinuria, low eGFR with proteinuria and low eGFR without proteinuria than in those with a high eGFR without proteinuria, with the most significant differences for these parameters. The eGFR was found to be significantly correlated with the log-apoB-48 and log-apoB-48/TG levels, whereas urinary protein was found to be significantly correlated with the log-apoB-48 level only. A multiple regression analysis indicated that the log-apoB-48/TG level was a significant determinant of a reduced eGFR.
  
  
  CONCLUSIONS
  Both a low eGFR (＜60) and proteinuria (≥1＋) are independent determinants of a high apoB-48 concentration. Taken together, the present results suggest that an increased serum apoB-48 concentration contributes to an increased risk of cardiovascular events.
authors.affiliation: Division of Laboratory for Clinical Investigation, Department of Medical Technology, Osaka University Hospital.
authors.forename: Manabu
authors.initials: M
authors.lastname: Okubo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hanada
authors.forename: Masahiko
authors.initials: M
authors.lastname: Matsui
authors.forename: Yoh
authors.initials: Y
authors.lastname: Hidaka
authors.forename: Daisaku
authors.initials: D
authors.lastname: Masuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sakata
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011507:Proteinuria / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D012307:Risk Factors
chemical_list: D053283:Apolipoprotein B-48; D015415:Biomarkers