title: The role of dendritic cells in tissue-specific autoimmunity.
abstract: In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity. Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented. Further, we compare tissue specific to systemic autoimmunity to demonstrate how development of dendritic cell-based therapies may be broadly applicable to both classes of autoimmunity. Continued development of these research areas will lead us closer to clinical assessment of novel immunosuppressive therapy for the reversal and prevention of tissue-specific autoimmunity. Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.
authors.affiliation: Center for Health Disparities and Molecular Medicine, 11085 Campus Street, Mortensen Hall, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
authors.forename: Jacques
authors.identifier: 0000-0002-7123-3480
authors.initials: J
authors.lastname: Mbongue
authors.affiliation: Center for Health Disparities and Molecular Medicine, 11085 Campus Street, Mortensen Hall, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
authors.forename: Dequina
authors.identifier: 0000-0003-4996-2190
authors.initials: D
authors.lastname: Nicholas
authors.affiliation: Endocrinology Section, JL Pettis Memorial VA Medical Center, Loma Linda, CA 92354, USA.
authors.forename: Anthony
authors.identifier: 0000-0003-4433-1349
authors.initials: A
authors.lastname: Firek
authors.affiliation: Center for Health Disparities and Molecular Medicine, 11085 Campus Street, Mortensen Hall, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
authors.forename: William
authors.initials: W
authors.lastname: Langridge
mesh_terms: D056704:Adaptive Immunity; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D015551:Autoimmunity; D019070:Cell Lineage / Q000276:immunology; D064987:Cell- and Tissue-Based Therapy; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology* / Q000276:immunology; D015316:Genetic Therapy; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000627:therapeutic use; D009928:Organ Specificity
chemical_list: D007155:Immunologic Factors