title: Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy.
abstract: OBJECTIVE
  The purpose of our study was to test our hypothesis that multiparametric magnetic resonance imaging (mpMRI) may have a higher prognostic accuracy than the Partin tables in predicting organ-confined (OC) prostate cancer and extracapsular extension (ECE) after radical prostatectomy (RP).
  
  
  METHODS
  After institutional review board approval, we retrospectively reviewed 60 patients who underwent 3-T mpMRI before RP. mpMRI was used to assess clinical stage and the updated version of the Partin tables was used to calculate the probability of each patient to harbor OC disease. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of mpMRI in detecting OC and ECE were calculated. Logistic regression models predicting OC pathology were created using either clinical stage at mpMRI or Partin tables probability. The area under the curve was used to calculate the predictive accuracy of each model.
  
  
  RESULTS
  Median prostate-specific antigen level at diagnosis was 5 ng/ml (range: 4.1-6.7 ng/ml). Overall, 52 (86.7%) men had cT1 disease, 7 (11.7%) had cT2a/b, and 1 (1.6%) had cT3b at digital rectal examination. Biopsy Gleason score was 6, 3+4 = 7, 4+3 = 7, 8, and 9 to 10 in 28 (46.7%), 15 (25%), 3 (5%), 10 (16.7%), and 4 (6.6%) patients, respectively. At mpMRI, clinical stage was defined as cT2a/b, cT2c, cT3a, and cT3b in 11 (18.3%), 23 (38.3%), 21 (35%), and 5 (8.4%) patients, respectively. At final pathology, 38 men (63.3%) had OC disease, whereas 18 (30%) had ECE and 4 (6.7%) had seminal vesicle invasion. The sensitivity, specificity, PPV, and NPV of mpMRI in detecting OC disease were 81.6%, 86.4%, 91.2%, and 73.1%, respectively, whereas in detecting ECE were 77.8%, 83.4%, 66.7%, and 89.7%, respectively. At logistic regression, both the Partin tables-derived probability and the mpMRI clinical staging were significantly associated with OC disease (all P<0.01). The area under the curves of the model built using the Partin tables and that of the mpMRI model were 0.62 and 0.82, respectively (P = 0.04).
  
  
  CONCLUSIONS
  The predictive accuracy of mpMRI in predicting OC disease on pathological analysis is significantly greater than that of the Partin tables. mpMRI had a high PPV (91.2%) when predicting OC disease and a high NPV (89.7%) with regard to ECE. mpMRI should be considered when planning prostate cancer treatment in addition to readily available clinical parameters.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC. Electronic address: rajan.gupta@duke.edu.
authors.forename: Rajan T
authors.initials: RT
authors.lastname: Gupta
authors.affiliation: Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD.
authors.forename: Kamil F
authors.initials: KF
authors.lastname: Faridi
authors.affiliation: Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC.
authors.forename: Abhay A
authors.initials: AA
authors.lastname: Singh
authors.affiliation: Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC.
authors.forename: Niccolò M
authors.initials: NM
authors.lastname: Passoni
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC.
authors.forename: Kirema
authors.initials: K
authors.lastname: Garcia-Reyes
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC.
authors.forename: John F
authors.initials: JF
authors.lastname: Madden
authors.affiliation: Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Polascik
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009367:Neoplasm Staging; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*
keywords: Multiparametric prostate MRI; Partin tables; Prostate cancer