title: Complications associated with parenteral nutrition in the neonate.
abstract: Although parenteral nutrition (PN) is life-sustaining, it is associated with many complications including parenteral nutrition-associated liver disease (PNALD) and central line-associated bloodstream infections (CLASBIs), which carry a high morbidity and mortality and impose a burden on the health care system. Evidence has emerged that the dose and composition of intravenous lipid products may alter the incidence of PNALD. However, other patient and PN-related factors, such as prematurity, birth weight, and gastrointestinal anatomy and function, are important. To improve neonatal care, future research on optimizing the content of PN and decreasing the incidence IFALD and CLASBIs is required.
authors.affiliation: Division of Neonatology and Developmental Biology, Department of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: KCalkins@mednet.ucla.edu.
authors.forename: Kara L
authors.initials: KL
authors.lastname: Calkins
authors.affiliation: Division of Gastroenterology, Department of Pediatrics, Mattel Children's Hospital, University of California, 10833 Le Conte Avenue, MDCC, Los Angeles, Los Angeles, CA 90095-1752, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Venick
authors.affiliation: Division of Neonatology and Developmental Biology, Department of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Sherin U
authors.initials: SU
authors.lastname: Devaskar
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008107:Liver Diseases / Q000209:etiology*; D010288:Parenteral Nutrition / Q000009:adverse effects*
keywords: Infections; Lipids; Neonates; Parenteral nutrition; Parenteral nutrition–associated liver disease