title: The interaction pattern between a homology model of 40S ribosomal S9 protein of Rhizoctonia solani and 1-hydroxyphenaize by docking study.
abstract: 1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani. In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein. Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.
authors.affiliation: Agronomy and Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Dharni
authors.affiliation: Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
authors.lastname: Sanchita
authors.affiliation: Crop Protection Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
authors.forename: Abdul
authors.identifier: 0000-0002-9392-4549
authors.initials: A
authors.lastname: Samad
authors.affiliation: Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Agronomy and Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
authors.forename: Dharani Dhar
authors.initials: DD
authors.lastname: Patra
mesh_terms: D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000494:pharmacology; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D062105:Molecular Docking Simulation; D008969:Molecular Sequence Data; D010619:Phenazines / Q000737:chemistry / Q000494:pharmacology; D017433:Protein Structure, Secondary; D012232:Rhizoctonia / Q000187:drug effects / Q000378:metabolism*; D000091243:Ribosomal Protein S9; D012269:Ribosomal Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D054682:Ribosome Subunits, Small, Eukaryotic / Q000737:chemistry* / Q000378:metabolism; D040681:Structural Homology, Protein
chemical_list: D000935:Antifungal Agents; D005656:Fungal Proteins; D008024:Ligands; D010619:Phenazines; D000091243:Ribosomal Protein S9; D012269:Ribosomal Proteins; C050093:1-hydroxyphenazine