title: Maternal methamphetamine use in pregnancy and long-term neurodevelopmental and behavioral deficits in children.
abstract: OBJECTIVE
  To describe neurodevelopmental and/or behavioral findings among a cohort of South African children exposed to maternal methamphetamine (MA) use during pregnancy.
  
  
  METHODS
  Developmental assessments with the Griffiths Mental Developmental Scales (GMDS) were completed on a pilot cohort of 15 toddlers aged 2-4 years with a known history of maternal MA use during pregnancy. These were compared to a matched cohort of 21 toddlers without a history of maternal MA use. Each child underwent formal auditory testing and vision screen. The Child Behavior Checklist (CBCL) was completed by a parent or caregiver. Cohorts were matched for age, gestational age at birth, socio-economic status and geographic distribution.
  
  
  RESULTS
  Baseline characteristics were similar between the two groups. Most significant areas of poorer performance on GMDS in the Methamphetamine-exposed cohort was noted on the Personal-Social Ability Subscale (p<0.0001) and on the Hand and Eye Co-ordination Subscale (p=0.0002), while lower scores were also obtained on General Quotients (p=0.022). There were also significant concerns regarding aggressive behavior and attention deficit/hyperactivity on the CBCL for the exposed group, although this did not reach statistical significance.
  
  
  CONCLUSIONS
  Among children exposed to maternal MA use during pregnancy, specific developmental and behavioral deficits were increased when compared to controls. This correlates well with available literature. Larger sample sizes would help further support these findings and more definitively distinguish behavioral deficits.
authors.forename: Jessie van
authors.initials: Jv
authors.lastname: Dyk
authors.forename: Veruschka
authors.initials: V
authors.lastname: Ramanjam
authors.forename: Paige
authors.initials: P
authors.lastname: Church
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
authors.forename: Kirsten
authors.initials: K
authors.lastname: Donald
mesh_terms: D019969:Amphetamine-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000453:epidemiology*; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D010865:Pilot Projects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis / Q000453:epidemiology*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D008694:Methamphetamine