title: Astringency: a more stringent definition.
abstract: Despite being an everyday sensory experience, the nature of astringency perception is not clear. In this issue of Chemical Senses, Schöbel et al. demonstrate that astringency is a trigeminal sensation in human, and astringents trigger a G protein-coupled pathway in trigeminal ganglion cells in the mouse.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA, University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA and yj31@duke.edu.
authors.forename: Yue
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
authors.forename: Naihua N
authors.initials: NN
authors.lastname: Gong
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA, Department of Neurobiology, Duke Institutes for Brain Sciences, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsunami
mesh_terms: D000818:Animals; D001252:Astringents / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009055:Mouth / Q000502:physiology; D015398:Signal Transduction; D013649:Taste; D012668:Trigeminal Ganglion / Q000166:cytology* / Q000502:physiology
chemical_list: D001252:Astringents; D019204:GTP-Binding Proteins
keywords: G protein; astringency; taste; trigeminal sensation