title: Radiotherapy for soft tissue sarcoma: 50 years of change and improvement.
abstract: Radiotherapy for soft tissue sarcoma (STS) has advanced significantly over the past 50 years. This review focuses briefly on the period from 1964 to 1999 and more substantially on the changes of the past 15 years, such as IMRT and image-guided radiotherapy (IG-RT), especially when brought together (IG-IMRT) in the same planning and delivery process to treat localized STS. In particular, the introduction of IG-RT, target volume definitions for IG-RT, and review of recent clinical trials using IG-RT to treat localized STS in extremity will be reviewed. Finally, potential investigational agents combined with IG-RT to improve outcomes in patients with localized STS are discussed.
authors.affiliation: From the Department of Radiation Oncology, Rush University Medical Center, Chicago, IL.
authors.forename: Dian
authors.initials: D
authors.lastname: Wang
authors.affiliation: From the Department of Radiation Oncology, Rush University Medical Center, Chicago, IL.
authors.forename: Ross A
authors.initials: RA
authors.lastname: Abrams
mesh_terms: D000818:Animals; D059186:Chemoradiotherapy, Adjuvant; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020360:Neoadjuvant Therapy; D018787:Radiation Oncology / Q000266:history / Q000639:trends*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000009:adverse effects / Q000266:history / Q000639:trends*; D018714:Radiotherapy, Adjuvant; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000266:history / Q000639:trends*; D012509:Sarcoma / Q000266:history / Q000473:pathology / Q000532:radiotherapy*; D012983:Soft Tissue Neoplasms / Q000266:history / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D016896:Treatment Outcome