title: Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging.
abstract: We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Lim
authors.forename: Byunghoon
authors.initials: B
authors.lastname: Kang
authors.forename: Yuna
authors.initials: Y
authors.lastname: Choi
authors.forename: Eunji
authors.initials: E
authors.lastname: Jang
authors.forename: Seungmin
authors.initials: S
authors.lastname: Han
authors.forename: Kwangyeol
authors.initials: K
authors.lastname: Lee
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Seungjoo
authors.initials: S
authors.lastname: Haam
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
mesh_terms: D000818:Animals; D041702:BALB 3T3 Cells; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible; D003287:Contrast Media / Q000138:chemical synthesis*; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis*; D011092:Polyethylene Glycols / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D011721:Pyrenes; D011092:Polyethylene Glycols; C030984:pyrene; D005682:Gadolinium