title: Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis.
abstract: Tumor necrosis factor (TNF) is involved in host resistance to several intracellular pathogens. Although the critical role of TNF receptor (TNFR)p55 in Leishmania (Leishmania) major infection has been demonstrated, the impact of TNFRp55 deficiency on L. (L.) amazonensis infection has not been explored. L. (L.) amazonensis-infected TNFRp55(-/-) mice failed to resolve lesions, whereas C57BL/6 wild-type mice completely healed. The susceptibility of the TNFRp55(-/-) mice was characterized by higher lesion size and histopathological damage in comparison with the wild-type mice. A marked increased of the splenic index was observed in the TNFRp55(-/-) mice after 15 weeks infection. These results show that in the absence of TNFRp55, L. (L.) amazonensis-infected knockout mice fail to resolve lesions, whereas wild-type mice completely heal.
authors.affiliation: Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza, CONICET, Argentina; Área de Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. Electronic address: diegocargnelutti@hotmail.com.
authors.forename: Diego Esteban
authors.initials: DE
authors.lastname: Cargnelutti
authors.affiliation: Área de Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Salomón
authors.affiliation: Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza, CONICET, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Celedon
authors.affiliation: Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza, CONICET, Argentina.
authors.forename: Fernando Darío
authors.initials: FD
authors.lastname: Cuello-Carrión
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CCT-Córdoba, CONICET, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Gea
authors.affiliation: Instituto Multidisiplinario de Investigaciones Biológicas San Luis (IMIBIO-SL), CCT-San Luis, CONICET, Argentina.
authors.forename: María Silvia
authors.initials: MS
authors.lastname: Di Genaro
authors.affiliation: Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza, CONICET, Argentina.
authors.forename: Eduardo Alberto
authors.initials: EA
authors.lastname: Scodeller
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease; D007894:Leishmania mexicana / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000235:genetics* / Q000473:pathology; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000172:deficiency*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000172:deficiency*
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; C069521:recombinant human tumor necrosis factor-binding protein-1
keywords: C57BL/6 mice; Infection susceptibility; Leishmania (Leishmania) amazonensis; TNFRp55(−/−); Wild type