title: [Effect of curcumin on antioxidant function in the mice with acute alcoholic liver injury].
abstract: OBJECTIVE
  To study the effect of curcumin on antioxidant function in the mice with acute alcoholic liver injury.
  
  
  METHODS
  50 male KM mices were randomly divided into 5 groups according to the weight, i. e. the normal control group, model control group, and curcumin low-dose group, middle-dose group, high-dose group (50, 100 and 200 mg/kg BW). After a 14-day administration, the relative liver weight, the content of MDA, the activity of SOD, GSH-Px, T-AOC in the liver tissue and the content of serum AST, ALT were determined.
  
  
  RESULTS
  Compared with the normal control group, all indexes of model control group were significantly different (P < 0.05). The content of serum AST and ALT at high-dose group were significantly decreased compared with model control group (P < 0.05). Meanwhile, the activity of SOD, GSH-Px and T-AOC in the liver tissue were increased significantly (P < 0.05), and the content of MDA decreased significantly (P < 0.05).
  
  
  CONCLUSIONS
  Curcumin can improve the antioxidant activity of the mice with acute alcoholism, and has good protective effects on acute alcoholic liver injury in mice.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Xingchang
authors.initials: X
authors.lastname: Pan
authors.forename: Lishi
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants; D003474:Curcumin / Q000494:pharmacology*; D008099:Liver; D008104:Liver Cirrhosis, Alcoholic / Q000517:prevention & control*; D008297:Male; D051379:Mice
chemical_list: D000975:Antioxidants; D003474:Curcumin