title: Differential expression of stromal aromatase in obese females is regulated by DNA methylation.
abstract: Obesity increases the incidence, progression and mortality of breast cancer among postmenopausal females. This is partly due to excessive estrogen production in the adipose tissue of obese females. Aromatase is a key enzyme in estrogen biosynthesis. In the current study, the tensional force‑triggered inducibility of aromatase expression was observed to vary in ASCs isolated from different disease‑free individuals. In addition, this phenomenon was associated with the activation of the aromatase PII promoter and its DNA methylation load. These findings highlight the impact of tensional forces on estrogen biosynthesis in obese females.
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Xian-Cheng
authors.initials: XC
authors.lastname: Zeng
authors.affiliation: Department of Breast Surgery, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ao
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou 510120, P.R. China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Yang
authors.affiliation: School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China.
authors.forename: Guang-Xian
authors.initials: GX
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Li
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Yue-Liang
authors.initials: YL
authors.lastname: Tang
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Xie
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Wen-Guang
authors.initials: WG
authors.lastname: He
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Yan-Nian
authors.initials: YN
authors.lastname: Huang
authors.affiliation: Department of Clinical Laboratory, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Affiliated Xixiang People's Hospital of Guangdong Medical College, Shenzhen 518102, P.R. China.
authors.forename: Rong-Jiang
authors.initials: RJ
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000201:enzymology*; D001141:Aromatase / Q000235:genetics / Q000378:metabolism*; D001374:Azacitidine / Q000031:analogs & derivatives / Q000494:pharmacology; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D018899:CpG Islands; D019175:DNA Methylation; D000077209:Decitabine; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D000077209:Decitabine; D001141:Aromatase; D001374:Azacitidine