title: Quantifying cross-border movements and migrations for guiding the strategic planning of malaria control and elimination.
abstract: BACKGROUND
  Identifying human and malaria parasite movements is important for control planning across all transmission intensities. Imported infections can reintroduce infections into areas previously free of infection, maintain 'hotspots' of transmission and import drug resistant strains, challenging national control programmes at a variety of temporal and spatial scales. Recent analyses based on mobile phone usage data have provided valuable insights into population and likely parasite movements within countries, but these data are restricted to sub-national analyses, leaving important cross-border movements neglected.
  
  
  METHODS
  National census data were used to analyse and model cross-border migration and movement, using East Africa as an example. 'Hotspots' of origin-specific immigrants from neighbouring countries were identified for Kenya, Tanzania and Uganda. Populations of origin-specific migrants were compared to distance from origin country borders and population size at destination, and regression models were developed to quantify and compare differences in migration patterns. Migration data were then combined with existing spatially-referenced malaria data to compare the relative propensity for cross-border malaria movement in the region.
  
  
  RESULTS
  The spatial patterns and processes for immigration were different between each origin and destination country pair. Hotspots of immigration, for example, were concentrated close to origin country borders for most immigrants to Tanzania, but for Kenya, a similar pattern was only seen for Tanzanian and Ugandan immigrants. Regression model fits also differed between specific migrant groups, with some migration patterns more dependent on population size at destination and distance travelled than others. With these differences between immigration patterns and processes, and heterogeneous transmission risk in East Africa and the surrounding region, propensities to import malaria infections also likely show substantial variations.
  
  
  CONCLUSIONS
  This was a first attempt to quantify and model cross-border movements relevant to malaria transmission and control. With national census available worldwide, this approach can be translated to construct a cross-border human and malaria movement evidence base for other malaria endemic countries. The outcomes of this study will feed into wider efforts to quantify and model human and malaria movements in endemic regions to facilitate improved intervention planning, resource allocation and collaborative policy decisions.
authors.affiliation: Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA. dpindolia@gmail.com.
authors.forename: Deepa K
authors.initials: DK
authors.lastname: Pindolia
authors.forename: Andres J
authors.initials: AJ
authors.lastname: Garcia
authors.forename: Zhuojie
authors.initials: Z
authors.lastname: Huang
authors.forename: Timothy
authors.initials: T
authors.lastname: Fik
authors.forename: David L
authors.initials: DL
authors.lastname: Smith
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Tatem
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003140:Communicable Disease Control / Q000379:methods*; D060740:Disease Eradication / Q000379:methods*; D005260:Female; D063426:Human Migration; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission; D008297:Male; D008875:Middle Aged; D013636:Tanzania / Q000453:epidemiology; D014454:Uganda / Q000453:epidemiology; D055815:Young Adult