title: Functional significance of microsatellite markers.
abstract: The review summarizes literature data on the positive results of association studies between the length of microsatellite repeats and predisposition to pathologies. Actually, the data can be classified according to the localization of the microsatellite: in the gene promoter, in the part of exon 1 coding the signal sequence, in gene introns, in the coding areas of genes, and in 3'-untranslated regions. The functional significance of microsatellite length changes can be evaluated in many cases. The authors came up to the conclusion that further studies on microsatellite associations with diseases remain prospective as they reflect changes in the gene functional activity.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Sjakste
authors.forename: Natalia
authors.initials: N
authors.lastname: Paramonova
authors.affiliation: Faculty of Medicine, University of Latvia, Raiņa bulvāris 19, 1586 Riga, Latvia. nikolajs.sjakste@lu.lv.
authors.forename: Nikolajs
authors.initials: N
authors.lastname: Sjakste
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D005091:Exons / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics*; D011401:Promoter Regions, Genetic
chemical_list: D020413:3' Untranslated Regions; D005819:Genetic Markers