title: Multicenter analysis of gestational trophoblastic neoplasia in Turkey.
abstract: BACKGROUND
  To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey.
  
  
  METHODS
  A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated.
  
  
  RESULTS
  From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients.
  
  
  CONCLUSIONS
  Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey E-mail : drelcinuzmez@hotmail.com.
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mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D007044:Hysterectomy; D015994:Incidence; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D018245:Trophoblastic Tumor, Placental Site / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D014421:Turkey; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D055815:Young Adult