title: Prediction of future labour market outcome in a cohort of long-term sick-listed Danes.
abstract: BACKGROUND
  Targeted interventions for the long-term sick-listed may prevent permanent exclusion from the labour force. We aimed to develop a prediction method for identifying high risk groups for continued or recurrent long-term sickness absence, unemployment, or disability among persons on long-term sick leave.
  
  
  METHODS
  We obtained individual characteristics and follow-up data from the Danish Register of Sickness Absence Compensation Benefits and Social Transfer Payments (RSS) during 2004 to 2010 for 189,279 Danes who experienced a period of long-term sickness absence (4+ weeks). In a learning data set, statistical prediction methods were built using logistic regression and a discrete event simulation approach for a one year prediction horizon. Personalized risk profiles were obtained for five outcomes: employment, unemployment, recurrent sickness absence, continuous long-term sickness absence, and early retirement from the labour market. Predictor variables included gender, age, socio-economic position, job type, chronic disease status, history of sickness absence, and prior history of unemployment. Separate models were built for times of economic growth (2005-2007) and times of recession (2008-2010). The accuracy of the prediction models was assessed with analyses of Receiver Operating Characteristic (ROC) curves and the Brier score in an independent validation data set.
  
  
  RESULTS
  In comparison with a null model which ignored the predictor variables, logistic regression achieved only moderate prediction accuracy for the five outcome states. Results obtained with discrete event simulation were comparable with logistic regression.
  
  
  CONCLUSIONS
  Only moderate prediction accuracy could be achieved using the selected information from the Danish register RSS. Other variables need to be included in order to establish a prediction method which provides more accurate risk profiles for long-term sick-listed persons.
authors.affiliation: National Research Centre for the Working Environment (NRCWE), Lersø Parkallé 105, DK-2100, Copenhagen Ø, Denmark. jpe@arbejdsmiljoforskning.dk.
authors.forename: Jacob
authors.initials: J
authors.lastname: Pedersen
authors.forename: Thomas Alexander
authors.initials: TA
authors.lastname: Gerds
authors.forename: Jakob Bue
authors.initials: JB
authors.lastname: Bjorner
authors.forename: Karl Bang
authors.initials: KB
authors.lastname: Christensen
mesh_terms: D000041:Absenteeism; D000328:Adult; D003718:Denmark; D006233:Persons with Disabilities; D057172:Economic Recession / Q000706:statistics & numerical data; D004651:Employment / Q000639:trends*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D018582:Sick Leave / Q000706:statistics & numerical data*; D055815:Young Adult