title: Optimization of cell adhesion on mg based implant materials by pre-incubation under cell culture conditions.
abstract: Magnesium based implants could revolutionize applications where orthopedic implants such as nails, screws or bone plates are used because they are load bearing and degrade over time. This prevents a second surgery to remove conventional implants. To improve the biocompatibility we studied here if and for how long a pre-incubation of the material under cell culture conditions is favorable for cell attachment and proliferation. For two materials, Mg and Mg10Gd1Nd, we could show that 6 h pre-incubation are already enough to form a natural protective layer suitable for cell culture.
authors.affiliation: Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Max-Planck-Str. 1, Geesthacht 21502, Germany. regine.willumeit@hzg.de.
authors.forename: Regine
authors.initials: R
authors.lastname: Willumeit
authors.affiliation: Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Max-Planck-Str. 1, Geesthacht 21502, Germany. anmo@tf.uni-kiel.de.
authors.forename: Anneke
authors.initials: A
authors.lastname: Möhring
authors.affiliation: Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Max-Planck-Str. 1, Geesthacht 21502, Germany. frank.feyerabend@hzg.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Feyerabend
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D018929:Cell Culture Techniques; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003764:Dental Materials / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D003764:Dental Materials; D008274:Magnesium