title: Celiac disease screening in Brazilian patients with osteoporosis.
abstract: OBJECTIVE
  To analyze if it is worthwhile to screen Brazilian osteoporotic patients for celiac disease (CD).
  
  
  METHODS
  One hundred patients with osteoporosis and 97 controls were evaluated for IgA-EmA (IgA anti-endomysial antibodies) by indirect immunofluorescence method and IgG-anti-tTG (tissue transglutaminase) by ELISA assay. Positive patients were invited to have gastrointestinal endoscopy with jejunal biopsy.
  
  
  RESULTS
  Two patients had positive IgG-anti-tTG test and one of them also showed positive IgA-EmA. Only the latter had a positive duodenal biopsy for CD. None of the controls were positive for either auto-antibodies.
  
  
  CONCLUSIONS
  We observed low prevalence of CD in osteoporotic Brazilian patients. This finding does not support routine screening for CD in patients with osteoporosis in our geographic region.
authors.affiliation: Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.
authors.forename: Luiza
authors.initials: L
authors.lastname: Gusso
authors.affiliation: Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.
authors.forename: Mariana Cionek
authors.initials: MC
authors.lastname: Simões
authors.affiliation: Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
authors.affiliation: Universidade Positivo, Curitiba, PR, Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Nisihara
authors.affiliation: Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.
authors.forename: Claudine C
authors.initials: CC
authors.lastname: Burkiewicz
authors.affiliation: Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Shirley
authors.initials: S
authors.lastname: Utiyama
mesh_terms: D000368:Aged; D001323:Autoantibodies; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002446:Celiac Disease / Q000175:diagnosis* / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D010024:Osteoporosis / Q000453:epidemiology*; D015995:Prevalence; D011503:Transglutaminases / Q000097:blood / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D011503:Transglutaminases