title: Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems.
abstract: The biopharmaceutical properties of doxorubicin delivered via two drug-delivery systems (DDSs) for the palliative treatment of unresectable hepatocellular carcinoma were reviewed with relation to the associated liver and tumor (patho)physiology. These two DDSs, doxorubicin emulsified with Lipiodol(®) and doxorubicin loaded into DC Bead(®) are different regarding tumor delivery, release rate, local bioavailability, if and how they can be given repeatedly, biodegradability, length of embolization and safety profile. There have been few direct head-to-head comparisons of these DDSs, and in-depth investigations into their in vitro and in vivo performance is warranted.
authors.affiliation: Department of Pharmacy, Uppsala University; Box 580, SE-751 23 Uppsala, Sweden.
authors.forename: Ilse R
authors.initials: IR
authors.lastname: Dubbelboer
authors.forename: Elsa
authors.initials: E
authors.lastname: Lilienberg
authors.forename: Emelie
authors.initials: E
authors.lastname: Ahnfelt
authors.forename: Erik
authors.initials: E
authors.lastname: Sjögren
authors.forename: Niklas
authors.initials: N
authors.lastname: Axén
authors.forename: Hans
authors.initials: H
authors.lastname: Lennernäs
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D001682:Biological Availability; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D004337:Drug Carriers; D004355:Drug Stability; D004998:Ethiodized Oil / Q000737:chemistry*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012995:Solubility; D014018:Tissue Distribution
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; C062364:polyvinyl alcohol hydrogel; D004998:Ethiodized Oil; D004317:Doxorubicin; D011142:Polyvinyl Alcohol