title: The soft underbelly of tumor cells.
abstract: In a recent Cell paper, Kitambi and colleagues identify a small molecule (Vacquinol-1) that has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: S Kyun
authors.initials: SK
authors.lastname: Lim
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Parada
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D010880:Piperidines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000494:pharmacology*
chemical_list: D010880:Piperidines; D011804:Quinolines; D054852:Small Molecule Libraries