title: Surgical management of recurrent sinonasal mucosal melanoma: endoscopic or transfacial resection.
abstract: Sinonasal mucosal melanoma (SNMM) is associated with poor prognosis. Local recurrence is common and represents a major problem in the therapy. Wide resection surgery is usually applied. However, given the almost futile prognosis, optimal symptom control may be preferable to wide resection at all costs. The aim of our study was to analyze the outcome in patients with recurrent SNMM treated by transfacial radical surgery or by a less invasive endoscopically controlled approach. Patients with recurrent grade III or IV staged SNMM who presented to our ENT department between 2000 and 2010 were either treated by transfacial (n = 10) or endoscopically controlled surgery (n = 12). The patients' charts were reviewed for clinical symptoms, relapse-free time and survival time. Clinical symptoms improved after surgery. The morbidity after endoscopic surgery was significantly lower than after transfacial surgery. The chosen surgical technique did neither affect relapse-free nor survival time. When treating recurrent SNMM, the comparatively gentle and less mutilating endoscopic approach proved to be a sufficient surgical procedure, being not inferior to aggressive surgery with respect to recurrence and survival rate.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University Munich, Marchioninistr. 15, 81377, Munich, Germany, johannes_georg.ledderose@med.uni-muenchen.de.
authors.forename: G J
authors.initials: GJ
authors.lastname: Ledderose
authors.forename: A
authors.initials: A
authors.lastname: Leunig
mesh_terms: D018572:Disease-Free Survival; D004724:Endoscopy; D005145:Face / Q000601:surgery*; D006801:Humans; D008545:Melanoma / Q000601:surgery*; D009297:Nasal Mucosa / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate