title: Self-healing hybrid nanocomposites consisting of bisphosphonated hyaluronan and calcium phosphate nanoparticles.
abstract: Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds.
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands.
authors.forename: M Reza
authors.initials: MR
authors.lastname: Nejadnik
authors.affiliation: Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121 Uppsala, Sweden.
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands.
authors.forename: Matilde
authors.initials: M
authors.lastname: Bongio
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands.
authors.forename: Hamdan S
authors.initials: HS
authors.lastname: Alghamdi
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands.
authors.forename: Jeroen J J P
authors.initials: JJ
authors.lastname: van den Beucken
authors.affiliation: Department of Preventive and Restorative Dentistry, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands.
authors.forename: Marie C
authors.initials: MC
authors.lastname: Huysmans
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands.
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
authors.affiliation: Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121 Uppsala, Sweden.
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
authors.affiliation: Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121 Uppsala, Sweden. Electronic address: dmitri.ossipov@kemi.uu.se.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Ossipov
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands. Electronic address: sander.leeuwenburgh@radboudumc.nl.
authors.forename: Sander C G
authors.initials: SC
authors.lastname: Leeuwenburgh
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D004164:Diphosphonates; D020100:Hydrogels; D006820:Hyaluronic Acid; D017886:Durapatite; C020243:calcium phosphate
keywords: Bone regeneration; Hydrogels; Organic-inorganic nanocomposites; Reversible bonds; Self-healing materials