title: Defining the radiobiology of prostate cancer progression: An important question in translational prostate cancer research.
abstract: Prostate cancer is one of the most common malignancies affecting men worldwide. High mortality rates from advanced and metastatic prostate cancer in the United States are contrasted by a relatively indolent course in the majority of cases. This gives hope for finding methods that could direct personalized diagnostic, preventative, and treatment approaches to patients with prostate cancer. Recent advances in multiparametric magnetic resonance imaging (MP-MRI) offer a noninvasive diagnostic intervention which allows correlation of prostate tumor image characteristics with underlying biologic evidence of tumor progression. The power of MP-MRI includes examination of both local invasion and nodal disease and might overcome the challenges of analyzing the multifocal nature of prostate cancer. Future directions include a careful analysis of the genomic signature of individual prostatic lesions utilizing image-guided biopsies. This review examines the diagnostic potential of MRI in prostate cancer.
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA vourgans@upstate.edu kotulal@upstate.edu.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Vourganti
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Donaldson
authors.affiliation: Molecular Imaging Program, Urologic Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Johnson
authors.affiliation: Molecular Imaging Program, Urologic Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Gennady
authors.initials: G
authors.lastname: Bratslavsky
authors.affiliation: Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Leszek
authors.initials: L
authors.lastname: Kotula
keywords: Prostate cancer; image-guided biopsy; lymph node imaging; magnetic resonance imaging; radiobiology