title: Durable defense: robust and varied attachment of non-leaching poly"-onium" bactericidal coatings to reactive and inert surfaces.
abstract: Developing antimicrobial coatings to eliminate biotic contamination is a critical need for all surfaces, including medical, industrial, and domestic materials. The wide variety of materials used in these fields, from natural polymers to metals, require coatings that not only are antimicrobial, but also contain different surface chemistries for covalent immobilization. Alkyl "-onium" salts are potent biocides that have defied bacterial resistance mechanisms when confined to an interface. In this feature article, we highlight the various methods used to covalently immobilize bactericidal polymers to different surfaces and further examine the mechanistic aspects of biocidal action with these surface bound poly"-onium" salts.
authors.affiliation: Department of Chemistry, College of Engineering, and Nanoscale Science and Engineering Center, 220 Riverbend Rd., Athens, GA, USA. jlocklin@uga.edu.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Yatvin
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Jason
authors.initials: J
authors.lastname: Locklin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D055808:Drug Discovery / Q000379:methods*; D011108:Polymers / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D011108:Polymers; D012492:Salts