title: Metabolic variation between japonica and indica rice cultivars as revealed by non-targeted metabolomics.
abstract: Seed metabolites are critically important both for plant development and human nutrition; however, the natural variation in their levels remains poorly characterized. Here we profiled 121 metabolites in mature seeds of a wide panel Oryza sativa japonica and indica cultivars, revealing correlations between the metabolic phenotype and geographic origin of the rice seeds. Moreover, japonica and indica subspecies differed significantly not only in the relative abundances of metabolites but also in their corresponding metabolic association networks. These findings provide important insights into metabolic adaptation in rice subgroups, bridging the gap between genome and phenome, and facilitating the identification of genetic control of metabolic properties that can serve as a basis for the future improvement of rice quality via metabolic engineering.
authors.affiliation: 1] National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China [2].
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Hu
authors.affiliation: 1] National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China [2].
authors.forename: Jianxin
authors.initials: J
authors.lastname: Shi
authors.affiliation: 1] National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China [2].
authors.forename: Sheng
authors.initials: S
authors.lastname: Quan
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.affiliation: Systems Biology and Mathematical Modeling Group, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Kleessen
authors.affiliation: Systems Biology and Mathematical Modeling Group, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Nikoloski
authors.affiliation: Central Metabolism Group, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tohge
authors.affiliation: Metabolon Inc., Durham, North Carolina 27713, USA.
authors.forename: Danny
authors.initials: D
authors.lastname: Alexander
authors.affiliation: Metabolon Inc., Durham, North Carolina 27713, USA.
authors.forename: Lining
authors.initials: L
authors.lastname: Guo
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Cui
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Rao
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huaian, Jiangsu, 223300, China.
authors.forename: Xiangxiang
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Central Metabolism Group, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
authors.forename: Alisdair R
authors.initials: AR
authors.lastname: Fernie
authors.affiliation: National Center for Molecular Characterization of Genetically Modified Organisms, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Dabing
authors.initials: D
authors.lastname: Zhang
mesh_terms: D018556:Crops, Agricultural; D014644:Genetic Variation; D006801:Humans; D060847:Metabolic Engineering; D055432:Metabolomics; D012275:Oryza / Q000235:genetics / Q000378:metabolism*; D012639:Seeds / Q000235:genetics / Q000378:metabolism*