title: The effects of caffeine on the cholinergic system.
abstract: Caffeine is a secondary metabolite of tea and coffee plants. It is the active psychostimulant ingredient of widely consumed beverages, chocolate and some drugs as well. The major pathways for caffeine including interaction with adenosine receptors have been identified but caffeine has several minor pathways as well that remain poorly understood including the cholinergic system. Given the role of caffeine in the cholinergic system, some molecular targets have been tracked and a mechanism of its action has been proposed in research studies. However, the biological effect of caffeine on the cholinergic system is not completely understood. The present review focuses on the role of caffeine in the cholinergic system.
authors.affiliation: Faculty of Military Health Sciences, University of Defence, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic; Karel English College in Brno, Sujanovo namesti 356/1, 60200 Brno, Czech Republic. miroslav.pohanka@gmail.com.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pohanka
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000241:Adenosine / Q000037:antagonists & inhibitors; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D002110:Caffeine / Q000302:isolation & purification / Q000494:pharmacology*; D018678:Cholinergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D011950:Receptors, Cholinergic / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018678:Cholinergic Agents; D016207:Cytokines; D011950:Receptors, Cholinergic; D002110:Caffeine; D002802:Cholinesterases; D000241:Adenosine; D000109:Acetylcholine