title: Enantioselective acylphosphonylation-dual Lewis acid-Lewis base activation of aldehyde and acylphosphonate.
abstract: Acetoxyphosphonates were obtained by a one-step procedure consisting of reaction of diethyl acetylphosphonate with prochiral aldehydes in the presence of a catalytic system comprising a chiral Lewis acid, an achiral Lewis base, and a Brønstedt base. Best results were obtained using a tridentate Schiff base aluminum(III) Lewis acidic complex, 1H-1,2,3-benzotriazole, and a tertiary amine such as DBU. The target compounds were in most cases obtained in high yields, but with moderate enantiomeric ratios (up to 78:22).
authors.affiliation: Department of Chemistry, Organic Chemistry, KTH Royal Institute of Technology , SE 10044 Stockholm, Sweden.
authors.forename: Ye-Qian
authors.initials: YQ
authors.lastname: Wen
authors.forename: Robin
authors.initials: R
authors.lastname: Hertzberg
authors.forename: Christina
authors.initials: C
authors.lastname: Moberg