title: Transition metal complexes of neocryptolepine analogues. Part I: synthesis, spectroscopic characterization, and invitro anticancer activity of copper(II) complexes.
abstract: New generation of copper(II) complexes with aminoalkylaminoneocryptolepine as bidentate ligands has been synthesized and it is characterized by elemental analyses, magnetic moment, spectra (IR, UV-Vis, (1)H NMR and ESR) and thermal studies. The IR data suggest the coordination modes for ligands which behave as a bidentate with copper(II) ion. Based on the elemental analysis, magnetic studies, electronic and ESR data, binuclear square planar geometry was proposed for complexes 7a, 7b, square pyramidal for 9a, 9b and octahedral for 8a, 8b, 10a, 10b. The molar conductance in DMF solution indicates that all complexes are electrolyte except 7a and 7b. The ESR spectra of solid copper(II) complexes in powder form showed an axial symmetry with (2)B1g as a ground state and hyperfine structure. The thermal stability and degradation of the ligands and their metal complexes were studied employing DTA and TG methods. The metal-free ligands and their copper(II) complexes were tested for their in vitro anticancer activity against human colon carcinoma (HT-29). The results showed that the synthesized copper(II) complexes exhibited higher anticancer activity than their free ligands. Of all the studied copper(II) complexes, the bromo-substituted complex 9b exhibited high anticancer activity at low micromolar inhibitory concentrations (IC50=0.58μM), compared to the other complexes and the free ligands.
authors.affiliation: El-Menoufia University, Faculty of Science, Chemistry Department, Shebin El koom, Egypt.
authors.forename: Sanaa Moustafa
authors.initials: SM
authors.lastname: Emam
authors.affiliation: El-Menoufia University, Faculty of Science, Chemistry Department, Shebin El koom, Egypt. Electronic address: ibrahimtantawy@yahoo.co.uk.
authors.forename: Ibrahim El Tantawy
authors.initials: Iel T
authors.lastname: El Sayed
authors.affiliation: El-Menoufia University, Faculty of Science, Chemistry Department, Shebin El koom, Egypt.
authors.forename: Nagla
authors.initials: N
authors.lastname: Nassar
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D060328:Magnetic Phenomena; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013696:Temperature; D028561:Transition Elements / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D011804:Quinolines; D028561:Transition Elements; C414982:neocryptolepine; D003300:Copper
keywords: Anticancer activity; Copper(II) complexes; Neocryptolepine; Spectroscopic characterization; Synthesis