title: Comparison of (68)Ga DOTATATE to 18F-FDG uptake is useful in the differentiation of residual or recurrent pituitary adenoma from the remaining pituitary tissue after transsphenoidal adenomectomy.
abstract: OBJECTIVE
  The evaluation of the remaining pituitary tissue and recurrent or residual tumor after the pituitary adenoma resection is difficult. However, it is essential to assess the size of the recurrent tumor and remaining pituitary reserve before resurgery. This study aimed to distinguish the remaining pituitary tissue from pituitary adenoma with Ga 1,4,7,10-tetraazacyclododecane-N,N',N″,N″'-tetraacetic acid-D-Phe,Tyr3-octreotate (DOTATATE) and F-FDG PET imaging in patients status post transsphenoidal adenomectomy.
  
  
  METHODS
  Thirty-five patients with suspected recurrent/residual pituitary tumors were retrospectively evaluated. All of these patients underwent DOTATATE and FDG PET/CT within 1 week before additional surgery. The DOTATATE and FDG uptake levels were compared. The image findings were then compared with pathology results after the additional surgery.
  
  
  RESULTS
  Residual or recurrent pituitary adenoma were confirmed pathologically in all 35 patients. One recurrent pituitary adenoma did not have either DOTATATE or FDG uptake. In the remaining 34 adenomas, 33 had higher FDG uptake than DOTATATE uptake. In comparison, DOTATATE had significant higher uptake than FDG in the remaining pituitary tissues in all cases.
  
  
  CONCLUSIONS
  Different degree of uptake of Ga DOTATATE and F-FDG PET/CT in the remaining pituitary tissue and recurrent/residual pituitary tumor indicated that combined analysis of Ga DOTATATE and F-FDG PET/CT might be of clinical value in differentiating recurrent/residual pituitary adenoma from the remaining pituitary tissue.
authors.affiliation: From the Departments of *Nuclear Medicine, and †Neurosurgery, Peking Union Medical College Hospital, Beijing, People's Republic of China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zhao
authors.forename: Jianqi
authors.initials: J
authors.lastname: Xiao
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhu
authors.forename: Fang
authors.initials: F
authors.lastname: Li
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D002921:Cicatrix / Q000000981:diagnostic imaging; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000601:surgery; D018365:Neoplasm, Residual / Q000000981:diagnostic imaging* / Q000601:surgery; D009942:Organometallic Compounds; D010902:Pituitary Gland / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D011877:Radionuclide Imaging; D013100:Sphenoid Bone / Q000601:surgery*
chemical_list: D009942:Organometallic Compounds; D019788:Fluorodeoxyglucose F18; C513399:gallium Ga 68 dotatate