title: Evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation.
abstract: Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation, the fundamental pathologic changes of allergy, but the potential roles of PARs in allergy remain obscure. Since many of these proteases are produced and actively involved in the pathologic process of inflammation including exudation of plasma components, inflammatory cell infiltration, and tissue damage and repair, PARs appear to make important contribution to allergy. The aim of the present review is to summarize the expression of PARs in inflammatory and structural cells, the influence of agonists or antagonists of PARs on cell behavior, and the involvement of PARs in allergic disorders, which will help us to better understand the roles of serine proteases and PARs in allergy.
authors.affiliation: Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning 121001, China ; Department of Pathophysiology, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
authors.forename: Huiyun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning 121001, China.
authors.forename: Shaoheng
authors.initials: S
authors.lastname: He
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D001491:Basophils / Q000166:cytology; D045744:Cell Line, Tumor; D016207:Cytokines / Q000378:metabolism; D004804:Eosinophils / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D006967:Hypersensitivity / Q000473:pathology*; D007249:Inflammation / Q000473:pathology*; D008264:Macrophages / Q000166:cytology; D008407:Mast Cells / Q000166:cytology; D009000:Monocytes / Q000166:cytology; D009504:Neutrophils / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D044462:Receptors, Proteinase-Activated / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology
chemical_list: D016207:Cytokines; D044462:Receptors, Proteinase-Activated