title: A case series of three US adults with Japanese encephalitis, 2010-2012.
abstract: BACKGROUND
  Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia. Although the risk for acquiring JE for most travelers to Asia is low, it varies based on the destination, season, trip duration, and activities.
  
  
  METHODS
  We present case reports of three US adults who were infected with JE virus while traveling or residing in Asia.
  
  
  RESULTS
  Among the three JE patients, the first made a 10-day trip to mainland China and participated in outdoor activities in a rural area, the second had been resident in Taiwan for 4 months, and the third, fatal case was an expatriate living in South Korea.
  
  
  CONCLUSIONS
  JE should be considered in the differential diagnosis for any patient with an acute neurologic infection, who has recently been in a JE-endemic country. Health-care providers should assess the itineraries of travelers to JE-endemic countries, provide guidance on personal protective measures to prevent vector-borne diseases, and consider recommending JE vaccine for travelers at increased risk for JE virus infection.
authors.affiliation: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hills
authors.forename: Juliet
authors.initials: J
authors.lastname: Stoltey
authors.forename: Diana
authors.initials: D
authors.lastname: Martínez
authors.forename: Paul Y
authors.initials: PY
authors.lastname: Kim
authors.forename: Heather
authors.initials: H
authors.lastname: Sheriff
authors.forename: Ana
authors.initials: A
authors.lastname: Zangeneh
authors.forename: Sally R
authors.initials: SR
authors.lastname: Eilerman
authors.forename: Marc
authors.initials: M
authors.lastname: Fischer
mesh_terms: D000328:Adult; D001208:Asia; D003937:Diagnosis, Differential; D004664:Encephalitis Virus, Japanese / Q000302:isolation & purification*; D004672:Encephalitis, Japanese / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D014195:Travel; D014481:United States
chemical_list: D022321:Japanese Encephalitis Vaccines