title: Membranous nephropathy associated with angiomatoid fibrous histiocytoma in a pediatric patient.
abstract: BACKGROUND
  Though membranous nephropathy is a much more common cause of nephrotic syndrome in the adult population, it accounts for only a small fraction of cases in pediatrics.
  
  
  METHODS
  We report a case of a 16-year-old boy with nephrotic syndrome due to membranous nephropathy in the setting of a rare tumor, angiomatoid fibrous histiocytoma. This patient's nephrotic-range proteinuria completely resolved following resection of this tumor. Angiomatoid fibrous histiocytoma, while known to cause other paraneoplastic syndromes such as anemia, has never been reported to cause membranous nephropathy.
  
  
  CONCLUSIONS
  This case highlights a novel and treatable secondary cause of membranous nephropathy. Because secondary causes are more common in children than in adults, a high index of suspicion for other underlying pathology including malignancy should be considered. It also suggests that urinalysis may be a helpful screening tool in cases of angiomatoid fibrous histiocytoma.
authors.affiliation: Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Mira A
authors.initials: MA
authors.lastname: Kohorst
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Tran
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Folpe
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sethi
authors.forename: Carola A S
authors.initials: CA
authors.lastname: Arndt
mesh_terms: D000293:Adolescent; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001365:Axilla / Q000473:pathology; D001706:Biopsy; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000150:complications* / Q000473:pathology / Q000601:surgery; D051677:Histiocytoma, Malignant Fibrous / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors