title: A missed diagnosis of acromegaly during a female-to-male gender transition.
abstract: We present a case of a 46-year-old transgender male who, during his female-to-male transition, presented with a pituitary apoplexy at the emergency department of a general hospital in the Netherlands. During admission, it turned out that he also suffered from acromegaly due to a growth hormone secreting pituitary adenoma for which he was successfully treated at our university hospital. Previously, his complaints typical of acromegaly were dismissed as attributable to the gender transition. Without the apoplexy, the disease probably would have remained masked by the history of transgenderism for a much longer period of time. It is, therefore, essential to keep looking for additional explanations for new pathology and complaints that cannot typically be attributed to the gender transition in these patients.
authors.affiliation: Division of Endocrinology, Department of Medicine, Radboud University Medical Centre, PO Box 9109, 6500 HB, Nijmegen, The Netherlands, Sean.Roerink@radboudumc.nl.
authors.forename: Sean
authors.initials: S
authors.lastname: Roerink
authors.forename: Diane
authors.initials: D
authors.lastname: Marsman
authors.forename: Arianne
authors.initials: A
authors.lastname: van Bon
authors.forename: Romana
authors.initials: R
authors.lastname: Netea-Maier
mesh_terms: D000172:Acromegaly / Q000175:diagnosis*; D005260:Female; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010899:Pituitary Apoplexy / Q000175:diagnosis; D057829:Gender-Affirming Procedures; D063106:Transgender Persons