title: Resveratrol-zinc combination for prostate cancer management.
abstract: Zinc, an essential trace element, plays a critical role in cell signaling, and defect(s) in zinc homeostasis may contribute to adverse physiological and pathological conditions, including cancer. Zinc is present in healthy prostate at a very high concentration, where it is required for important prostatic functions. However, zinc levels are significantly diminished in cancerous tissue, and intracellular zinc level is inversely correlated with prostate cancer progression. During neoplastic transformation, zinc-accumulating, citrate-producing normal prostate cells are metabolically transformed to citrate oxidizing cells that lose the ability to accumulate zinc. Interestingly, zinc has been shown to function as chemopreventive agent against prostate cancer, albeit at high doses, which may lead to many adverse effects. Therefore, novel means to enhance bioaccumulation of sufficient zinc in prostate cells via increasing zinc transport could be useful against prostate cancer. On the basis of available evidence, we present a possibility that the grape antioxidant resveratrol, when given with zinc, may lead to retuning the zinc homeostasis in prostate, thereby abolishing or reversing malignancy. If experimentally verified in in vivo model(s) of prostate cancer, such as transgenic mouse models, this may lead to novel means toward management of prostate cancer and other conditions with compromised zinc homeostasis.
authors.affiliation: Department of Dermatology; University of Wisconsin; Madison, WI USA.
authors.forename: Chandra K
authors.initials: CK
authors.lastname: Singh
authors.affiliation: Department of Dermatology; University of Wisconsin; Madison, WI USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Pitschmann
authors.affiliation: Department of Dermatology; University of Wisconsin; Madison, WI USA.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D006706:Homeostasis; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D013267:Stilbenes; D014131:Trace Elements; D015032:Zinc; D000077185:Resveratrol
keywords: chemoprevention; prostate cancer; resveratrol; zinc; zinc homeostasis; zinc transporters