title: Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy.
abstract: The development of photothermal agents (PTAs) with good stability, low toxicity, highly targeting ability and photothermal conversion efficiency is an essential pre-requisite to near-infrared photothermal therapy (PTT) in vivo. Herein, we report the readily available PEGylated Fe@Fe3O4 NPs, which possess triple functional properties in one entity - targeting, PTT, and imaging. Compared to Au nanorods, they exhibit comparable photothermal conversion efficiency (∼20%), and much higher photothermal stability. They also show a high magnetization value and transverse relaxivity (∼156 mm(-1) s(-1)), which should be applied for magnetic targeting MRI. With the Nd-Fe-B magnet (0.5 T) beside the tumour for 12 h on the xenograft HeLa tumour model, PEGylated Fe@Fe3O4 NPs exhibit an obvious accumulation. In tumour, the intensity of MRI signal is ∼ three folds and the increased temperature is ∼ two times than those without magnetic targeting, indicating the good magnetic targeting ability. Notably, the intrinsic high photothermal conversion efficiency and selective magnetic targeting effect of the NPs in tumour play synergistically in highly efficient ablation of cancer cells in vitro and in vivo.
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Shen
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yu
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Kong
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China; The Education Ministry Key Lab of Pesticide & Chemical Biology, South China Agricultural University, Guangzhou 510642, China. Electronic address: shipingy@shnu.edu.cn.
authors.forename: Shiping
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-000, United States. Electronic address: wwang@unm.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007259:Infrared Rays; D007501:Iron / Q000737:chemistry / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats
chemical_list: D058185:Magnetite Nanoparticles; D011092:Polyethylene Glycols; D007501:Iron
keywords: In vivo; Iron/iron oxide nanoparticles; Magnetic targeting; Photothermal therapy; Theranostics