title: Bis-naphtho-γ-pyrones from fungi and their bioactivities.
abstract: Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. shiqionglu@126.com.
authors.forename: Shiqiong
authors.initials: S
authors.lastname: Lu
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. pstianjin@cau.edu.cn.
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. sunweibo.1001@163.com.
authors.forename: Weibo
authors.initials: W
authors.lastname: Sun
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. mengjiajiax@163.com.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Meng
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. wangxiaohan99@126.com.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Wang
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. xiaoxiaofu@cau.edu.cn.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Fu
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. wangali526@163.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Wang
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. dwlai@cau.edu.cn.
authors.forename: Daowan
authors.initials: D
authors.lastname: Lai
authors.affiliation: Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China. liuyang01@caas.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. lgzhou@cau.edu.cn.
authors.forename: Ligang
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D019429:Integrase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D019429:Integrase Inhibitors; D061065:Polyketides; D011753:Pyrones