title: Genome stress response in early development.
abstract: Cells with irreparable genomic damage pose a problem for development and must be eliminated to prevent disease. Reporting in this issue of Developmental Cell, Iampietro et al. (2014) describe a mechanism in Drosophila that removes damaged nuclei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of specific mRNAs within the nucleus.
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: william_marzluff@med.unc.edu.
authors.forename: William F
authors.initials: WF
authors.lastname: Marzluff
authors.affiliation: Departments of Biology and Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: duronio@med.unc.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Duronio
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D064447:Checkpoint Kinase 2 / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D016601:RNA-Binding Proteins; C490155:SLBP protein, Drosophila; D064447:Checkpoint Kinase 2; C112435:lok protein, Drosophila