title: MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica.
abstract: Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H20 extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3'-dihydroxy-4-methoxy-benzophenone-6-O-beta-glucopyranoside (1), 2,4,3',4'-tetrahydroxy-benzophenone-6-O-beta-glucopyranoside (maclurin-6-O-f-glucopyranoside) (2) and 2,4,3'-trihydroxy-benzophenone-6-O-beta-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50 = 31.3 +/- 4 microM and 41 +/- 4.7 microM resp.).
authors.forename: Duygu
authors.initials: D
authors.lastname: Kaya
authors.forename: Anna K
authors.initials: AK
authors.lastname: Jäger
authors.forename: Funda N
authors.initials: FN
authors.lastname: Yalçin
authors.forename: Tayfun
authors.initials: T
authors.lastname: Ersöz
mesh_terms: D001577:Benzophenones / Q000737:chemistry*; D030012:Gentiana / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry*; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001577:Benzophenones; D005960:Glucosides; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase