title: Propranolol and periocular capillary hemangiomas: assessment of refractive effect.
abstract: OBJECTIVE
  To assess the effects of systemic propranolol on refractive error in infants with periocular capillary hemangiomas.
  
  
  METHODS
  A single-center study of consecutive patients with capillary hemangiomas treated with systemic propranolol. Refractive data were analyzed using Long's matrix formalism and the methods of Harris and Kaye.
  
  
  RESULTS
  Seventeen patients were included. At 6 months postoperatively, hemangioma size reduced from 3,214 to 1,806 mm(3) (standard deviation: 4,122 to 2,441). Mean refractive error in the affected eye significantly reduced: -1.25/0.38 × 36 (95% confidence intervals: -5.08/1.20 × 90 to 1.64/1.43 × 180, P = .048) with a smaller change (P = .06) in the unaffected eye of -1.01/+0.31 × 3.16 (95% confidence intervals: -4.02/+1.12 × 180 to +1.49/+0.51 × 90).
  
  
  CONCLUSIONS
  Propranolol produced a clinically significant reduction in the infants' refractive error and anisometropia. The reduction in the total refractive error and anisometropia has not been evident in previous analyses, which have concentrated on the change in the "cylinder" as the principal outcome measure.
authors.forename: Peter
authors.initials: P
authors.lastname: Glasman
authors.forename: Arvind
authors.initials: A
authors.lastname: Chandna
authors.forename: Harish
authors.initials: H
authors.lastname: Nayak
authors.forename: Simran
authors.initials: S
authors.lastname: Mangat
authors.forename: Stephen
authors.initials: S
authors.lastname: Kaye
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D001251:Astigmatism; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D018324:Hemangioma, Capillary / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011433:Propranolol / Q000008:administration & dosage*; D012029:Refraction, Ocular / Q000502:physiology; D012030:Refractive Errors / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol