title: Contraceptive-induced amenorrhoea leads to reduced migraine frequency in women with menstrual migraine without aura.
abstract: BACKGROUND
  Menstrual migraine without aura (MM) affects approximately 20% of female migraineurs in the general population. The aim of the present study was to investigate the influence of contraception on the attacks of migraine without aura (MO) in women with MM.
  
  
  RESULTS
  141 women from the general population with a history of MM according to the International Classification of Headache Disorders II (ICHD II) were interviewed by a headache specialist. Of 49 women with a history of MM currently using hormonal contraception, 23 reported amenorrhoea. Significantly more women with amenorrhoea reported no MO- days during the preceding month compared to women without amenorrhoea (OR 16.1; 95% confidence interval (CI) 1.8-140.4; P = 0.003). A reduction of MO-frequency was more often reported in women with than without amenorrhoea (OR 3.5; 95% CI 1.1-11.4; P = 0.04).
  
  
  CONCLUSIONS
  Amenorrhoea leads to a reduction of MO-frequency in women with MM using hormonal contraceptives. Future prospective studies on MM should focus on contraceptive methods that achieve amenorrhoea.
authors.affiliation: Head and Neck Research Group, Research Centre, Akershus University hospital, 1478, Lørenskog, Norway. kjersti.vetvik@medisin.uio.no.
authors.forename: Kjersti Grøtta
authors.initials: KG
authors.lastname: Vetvik
authors.forename: E Anne
authors.initials: EA
authors.lastname: MacGregor
authors.forename: Christofer
authors.initials: C
authors.lastname: Lundqvist
authors.forename: Michael Bjørn
authors.initials: MB
authors.lastname: Russell
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced*; D003270:Contraceptive Agents / Q000627:therapeutic use*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008599:Menstruation Disturbances / Q000188:drug therapy*; D020326:Migraine without Aura / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D003270:Contraceptive Agents