title: miRNAs in PAH: biomarker, therapeutic target or both?
abstract: Pulmonary arterial hypertension (PAH) is characterized by progressive increase in pulmonary vascular resistance leading to right ventricular hypertrophy and failure. There is a need to find new biomarkers to detect PAH at its early stages and also for new, more effective treatments for this disease. miRNAs have emerged as key players in cardiovascular diseases and cancer development and progression and, more recently, in PAH pathogenesis. In this review, we focus on the potential of miRNAs as biomarkers and new therapeutic targets for PAH.
authors.affiliation: Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada.
authors.forename: Jolyane
authors.initials: J
authors.lastname: Meloche
authors.affiliation: Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada.
authors.forename: Aude
authors.initials: A
authors.lastname: Pflieger
authors.affiliation: Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada.
authors.forename: Mylène
authors.initials: M
authors.lastname: Vaillancourt
authors.affiliation: Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada.
authors.forename: Colin
authors.initials: C
authors.lastname: Graydon
authors.affiliation: Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada.
authors.forename: Steeve
authors.initials: S
authors.lastname: Provencher
authors.affiliation: Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada. Electronic address: sebastien.bonnet@criucpq.ulaval.ca.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Bonnet
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs