title: Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice.
abstract: This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration of TVB (14 mL kg(-1) body weight) to HF-fed mice for 6 weeks effectively reduced the body and visceral fat weight and significantly lowered plasma free fatty acid, triglyceride and hepatic triglyceride levels. TVB significantly increased fecal triglyceride excretion, both phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and peroxisome proliferator-activated receptor (PPAR)α protein levels in the liver, which were associated with increased fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice. TVB improved glucose tolerance, hyperinsulinemia and HOMA-IR levels in the HF + TVB group compared to the HF group. Additionally, TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, which enhanced glucose metabolism in obese mice. These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation.
authors.affiliation: Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Korea. leemk@sunchon.ac.kr.
authors.forename: Kwon-Il
authors.initials: KI
authors.lastname: Seo
authors.forename: Jin
authors.initials: J
authors.lastname: Lee
authors.forename: Ra-Yeong
authors.initials: RY
authors.lastname: Choi
authors.forename: Hae-In
authors.initials: HI
authors.lastname: Lee
authors.forename: Ju-Hye
authors.initials: JH
authors.lastname: Lee
authors.forename: Yong-Ki
authors.initials: YK
authors.lastname: Jeong
authors.forename: Myung-Joo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D019342:Acetic Acid / Q000494:pharmacology*; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001628:Beverages / Q000032:analysis*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005511:Food Handling; D006706:Homeostasis / Q000187:drug effects; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000178:diet therapy* / Q000209:etiology; D047493:PPAR alpha / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D047493:PPAR alpha; D014280:Triglycerides; D002784:Cholesterol; D055372:AMP-Activated Protein Kinases; D000103:Acetyl-CoA Carboxylase; D019342:Acetic Acid