title: The social network of PELP1 and its implications in breast and prostate cancers.
abstract: Proline, glutamic acid- and leucine-rich protein 1 (PELP1) is a multi-domain scaffold protein that serves as a platform for various protein-protein interactions between steroid receptors (SRs) and signaling factors and cell cycle, transcriptional, cytoskeletal, and epigenetic remodelers. PELP1 is known to be a coregulator of transcription and participates in the nuclear and extranuclear functions of SRs, ribosome biogenesis, and cell cycle progression. The expression and localization of PELP1 are dysregulated in hormonal cancers including breast and prostate cancers. This review focuses on the interactive functions and therapeutic and prognostic significance of PELP1 in breast and prostate cancers.
authors.affiliation: Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA.
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Gonugunta
authors.affiliation: Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA.
authors.forename: Gangadhara R
authors.initials: GR
authors.lastname: Sareddy
authors.affiliation: Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA.
authors.forename: Preethi
authors.initials: P
authors.lastname: Ravindranathan
authors.affiliation: Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA.
authors.forename: Ratna
authors.initials: R
authors.lastname: Vadlamudi
authors.affiliation: Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA ganesh.raj@utsouthwestern.edu.
authors.forename: Ganesh V
authors.initials: GV
authors.lastname: Raj
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D056970:Co-Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D056970:Co-Repressor Proteins; C438485:PELP1 protein, human; D014157:Transcription Factors
keywords: PELP1; coregulator; epigenetics; genomic signaling; hormonal cancers; interactome; network; nongenomic signaling; steroid receptors