title: Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man.
abstract: There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.
authors.affiliation: Fundació irsiCaixa, Badalona, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Franco
authors.affiliation: Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Universitat Autònoma de Barcelona (UAB), Spain; Universitat de Vic (UVic) Barcelona, Spain; Fundació Lluita contra la SIDA, Badalona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Tural
authors.affiliation: Fundació irsiCaixa, Badalona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Nevot
authors.affiliation: Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Universitat Autònoma de Barcelona (UAB), Spain; Universitat de Vic (UVic) Barcelona, Spain; Fundació Lluita contra la SIDA, Badalona, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Moltó
authors.affiliation: Department of Medicine I, Bonn University Hospital, Bonn, Germany.
authors.forename: Jürgen Kurt
authors.initials: JK
authors.lastname: Rockstroh
authors.affiliation: Fundació irsiCaixa, Badalona, Spain; Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Universitat Autònoma de Barcelona (UAB), Spain; Universitat de Vic (UVic) Barcelona, Spain; Fundació Lluita contra la SIDA, Badalona, Spain.
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.affiliation: Fundació irsiCaixa, Badalona, Spain. Electronic address: mmartinez@irsicaixa.es.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Martinez
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D010641:Phenotype; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D047568:Unsafe Sex; D019562:Viral Load; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
keywords: Cirrhosis; Liver Disease; Transmission