title: [Monosomal karyotype among adult acute myeloid leukemia: clinical characteristic and prognostic analysis].
abstract: OBJECTIVE
  To explore the clinical characteristics and prognostic value of monosomal karyotype (MK) patients in adult acute myeloid leukemia (AML).
  
  
  METHODS
  We retrospectively studied 45 patients of MK⁺ in newly-diagnosed adult AML in our center from Oct 2000 to Dec 2012. Clinical characteristics, cytogenetic data and prognostic features were analyzed in the cohort of MK⁺ patients.
  
  
  RESULTS
  MK was found in 45 patients (19.0%) of 237 newly-diagnosed adult AML with cytogenetic data available at diagnoses. Among these 45 cases, there were 28 male (62.2%) and 17 female (37.8%). Median age of MK⁺ patients at diagnose was 58(18-91) years old. The presence of -5(31.1%) and -7(17.8%) were the most common chromatid among MK⁺ AML patients. MK was much more prevalent among elderly patients. Among AML patients, the proportions of MK⁺ patients younger than 30, 30 to 59 and older than 60 years old groups were 11.5%, 17.7% and 22.4%, respectively. There was no difference between MK⁺ and MK⁻ patients in gender distribution (P=0.545). There was also no difference between MK⁺ and MK⁻ patients in the distribution of FAB castigation (P=0.239). Median survival of MK⁺ AML patients was 6.5 months. Cumulative 5-year overall survival (OS) of was 5.2%. Forty-three MK⁺ patients (43/45, 95.6%) also had a complex karyotype (CK). Two cases that did not meet the CK had not achieved complete remission (CR), and died within 6 months. There were 12 patients who were CK⁺ in 192 MK⁻ patients. The differences of OS and CR rates between MK⁺CK⁺ patients and MK⁻CK⁺ were statistically significant (P<0.05).
  
  
  CONCLUSIONS
  The increased detection rate of MK with age was associated with lower CR and OS in AML patients.
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Feng
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Naibai
authors.initials: N
authors.lastname: Chang
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Yeping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Haifei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Pei
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Shangyong
authors.initials: S
authors.lastname: Ning
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Xing
authors.affiliation: Department of Hematology, Beijing Hospital, Beijing 100730, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D055815:Young Adult