title: Rapid Hebbian axonal remodeling mediated by visual stimulation.
abstract: We examined how correlated firing controls axon remodeling, using in vivo time-lapse imaging and electrophysiological analysis of individual retinal ganglion cell (RGC) axons that were visually stimulated either synchronously or asynchronously relative to neighboring inputs in the Xenopus laevis optic tectum. RGCs stimulated out of synchrony rapidly lost the ability to drive tectal postsynaptic partners while their axons grew and added many new branches. In contrast, synchronously activated RGCs produced fewer new branches, but these were more stable. The effects of synchronous activation were prevented by the inhibition of neurotransmitter release and N-methyl-D-aspartate receptor (NMDAR) blockade, which is consistent with a role for synaptic NMDAR activation in the stabilization of axonal branches and suppression of further exploratory branch addition.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Munz
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.
authors.forename: Delphine
authors.initials: D
authors.lastname: Gobert
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.
authors.forename: Anne
authors.initials: A
authors.lastname: Schohl
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada. Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Jessie
authors.initials: J
authors.lastname: Poquérusse
authors.affiliation: Brain Research Centre, University of British Columbia (UBC), 2211 Westbrook Mall, Vancouver, BC V6T 2B5, Canada.
authors.forename: Kaspar
authors.initials: K
authors.lastname: Podgorski
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.
authors.forename: Perry
authors.initials: P
authors.lastname: Spratt
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada. edward.ruthazer@mcgill.ca.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Ruthazer
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D054351:Electrical Synapses / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D010775:Photic Stimulation; D011582:Psychological Theory; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D059008:Time-Lapse Imaging; D014982:Xenopus laevis
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate