title: The associations between VEGF gene polymorphisms and diabetic retinopathy susceptibility: a meta-analysis of 11 case-control studies.
abstract: AIMS. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic. METHODS. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF-2578C/A (rs699947), -1154G/A (rs1570360), -460T/C (rs833061), -634G>C (rs2010963), and +936C/T (rs3025039) in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0. RESULTS. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20-8.41, and P(z) = 0.01) in Asian and overall populations, while a significant association was also found between -460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12-4.01, and P(z) = 0.02). CONCLUSIONS. Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of -460T/C (rs833061) is associated with elevated DR susceptibility.
authors.affiliation: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Xing
authors.affiliation: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, China.
authors.forename: Renjie
authors.initials: R
authors.lastname: Zhuo
authors.affiliation: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, China.
authors.forename: XiaLu
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang Province 150081, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang Province 150081, China.
authors.forename: Qunhong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, China.
authors.forename: Jinshun
authors.initials: J
authors.lastname: Zhao
mesh_terms: D019943:Amino Acid Substitution; D044466:Asian People; D016022:Case-Control Studies; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000378:metabolism; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D013223:Statistics as Topic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A