title: Does helicobacter pylori infection have influence on outcome of laparoscopic sleeve gastrectomy for morbid obesity?
abstract: BACKGROUND
  Among the surgical procedures for treatment of morbid obesity, laparoscopic sleeve gastrectomy has known widespread diffusion in the last years, although it is not free from significant morbidity rates. Aim of this work is to evaluate the incidence of Helicobacter pylori (HP) infection on the postoperative outcome of patients undergoing laparoscopic sleeve gastrectomy.
  
  
  METHODS
  Between January 2008 and December 2013, 184 patients (65 males, 119 females), mean age 35.8 ± 5.7 years, affected with morbid obesity, mean BMI 46.6 ± 6.7, underwent laparoscopic sleeve gastrectomy. All the specimens at the end of the operation were analysed by the same pathologist. Histological grading was based on the Sidney classification.
  
  
  RESULTS
  Seventy-two of the patients (39.1%) were HP positive, while 112 (60.9%) were negative. No significant differences were observed between the HP+ and HP- group in terms of age, sex, weight, BMI, incidence of comorbidities and duration of follow-up. All the operations were completed via laparoscopic approach. No mortality was observed. Postoperative complications occurred in 5 patients (2.7%): three leaks (1.6%), all in the HP- group and two bleedings (1.1%), one in the HP+ and one in the HP- group. In two cases a reintervention was necessary. No significant differences were observed in the morbidity rates between the two groups. Overall mean excess weight loss at 6 months, 12 months and 24 months was respectively 47.4 ± 11.3%, 61.1 ± 12.4% and 68.4 ± 13.5%, with no significant differences between the HP+ and HP- groups.
  
  
  CONCLUSIONS
  HP infection seems not to influence postoperative outcome of patients operated of laparoscopic sleeve gastrectomy.
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy. Electronic address: gianlucarossetti@yahoo.it.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rossetti
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Moccia
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Marra
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Buonomo
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Beniamino
authors.initials: B
authors.lastname: Pascotto
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Pezzullo
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Napolitano
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Schettino
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Avellino
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Conzo
authors.affiliation: Department of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico II, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Amato
authors.affiliation: Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Docimo
authors.affiliation: Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Tolone
authors.affiliation: Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy.
authors.forename: Gianmattia
authors.initials: G
authors.lastname: Del Genio
authors.affiliation: Division of General and Bariatric Surgery, School of Medicine, Second University of Naples, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Docimo
authors.affiliation: Department of Anaesthesiological, Surgical and Emergency Sciences, Division of Digestive Surgery, School of Medicine, Second University of Naples, Via Pansini Naples 5, 80131 Naples, Italy.
authors.forename: Landino
authors.initials: L
authors.lastname: Fei
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D010535:Laparoscopy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000382:microbiology / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012086:Reoperation; D016896:Treatment Outcome; D015431:Weight Loss
keywords: Helicobacter pylori; Laparoscopy; Morbid obesity; Sleeve gastrectomy