title: Platycladus orientalis leaves: a systemic review on botany, phytochemistry and pharmacology.
abstract: Platycladus orientalis leaves (Cebaiye) have been used for thousands of years as traditional Chinese medicine (TCM). According to the theory of TCM, they are categorized as a blood-cooling and hematostatic herb. In clinical practice, they were usually prescribed with heat-clearing herbs to reinforce the efficacy of hemostasis. The review provides the up-to-date information from 1980 to present that is available on the botany, processing research, phytochemistry, pharmacology and toxicology of the leaves. The information is collected from scientific journals, books, theses and reports via library and electronic search (Google Scholar, Pubmed and CNKI). Through literature reports, we can find that the leaves show a wide spectrum of pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, disinsection, anticancer, diuretic, hair growth-promoting, neuroprotective and antifibrotic activities. Diterpene and flavonoids would be active constituents in P. orientalis leaves. Many studies have provided evidence for various traditional uses. However, there is a great need for additional studies to elucidate the mechanism of blood-cooling and hematostatic activity of the leaves. Therefore, the present review on the botany, traditional uses, phytochemistry and toxicity has provided preliminary information for further studies of this herb.
authors.affiliation: Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Ming-Qiu
authors.initials: MQ
authors.lastname: Shan
authors.forename: Jing
authors.initials: J
authors.lastname: Shang
authors.forename: An-Wei
authors.initials: AW
authors.lastname: Ding
mesh_terms: D000818:Animals; D006801:Humans; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D029779:Cupressaceae / Q000737:chemistry; D016206:Databases, Bibliographic; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004232:Diuretics; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006197:Hair / Q000254:growth & development; D007306:Insecticides; D008968:Molecular Conformation; D018696:Neuroprotective Agents; D064209:Phytochemicals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004224:Diterpenes; D004232:Diuretics; D005419:Flavonoids; D007306:Insecticides; D018696:Neuroprotective Agents; D064209:Phytochemicals; D010936:Plant Extracts