title: Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances.
abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Detection of OSCC is currently based on thorough clinical oral examination combined with biopsy for histological analysis. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early stage diagnostic marker is needed. This literature review presents an overview of the status of current advances in salivary diagnostics for OSCC. Though many protein and mRNA salivary biomarkers have been identified that can detect OSCC with high sensitivity and specificity, the most discernable findings occur with the use of multiple markers. Studies that incorporate proteomic, transcriptomic, and potentially additional "omics", including methylomics, need to be initiated to bring technology to clinical applications and allow the best use of saliva in diagnosing OSCC.
authors.affiliation: Center for Oral/Head & Neck Oncology Research, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
authors.forename: Maha
authors.initials: M
authors.lastname: Yakob
authors.affiliation: Center for Oral/Head & Neck Oncology Research, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
authors.forename: Laurel
authors.initials: L
authors.lastname: Fuentes
authors.affiliation: Center for Oral/Head & Neck Oncology Research, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
authors.forename: Marilene B
authors.initials: MB
authors.lastname: Wang
authors.affiliation: Center for Oral/Head & Neck Oncology Research, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
authors.forename: Elliot
authors.initials: E
authors.lastname: Abemayor
authors.affiliation: Center for Oral/Head & Neck Oncology Research, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
authors.forename: David T W
authors.initials: DT
authors.lastname: Wong
keywords: exosomes; metabolomics; methylomics; microbiomics; oral cancer; oral fluid diagnostics; oral squamous cell carcinoma; proteomics; salivaomics; salivary biomarker; salivary diagnostics; transcriptomics