title: [Immunogenetics of nasopharyngeal carcinoma].
abstract: Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Genetic predisposition linked to the immune system has been associated with various tumors. This involves genetic diversity of the genes encoding the molecules of the immune response such as inflammation and anti-tumor surveillance. In this work, we examined the impact of the immunogenetic diversity on the risk of the NPC in different populations studied. These data show that the interindividual variability of the genetic regulation of immune processes increases the risk of NPC in individuals previously predisposed due to other risk factors (genetic / environmental). This synthesis, in addition to the predictive aspects, could provide innovative research for the development of new therapeutic approaches.
authors.affiliation: Laboratoire de biologie clinique, Institut Salah Azaiz, Tunis, Tunisie, Laboratoire Jean Dausset d'immunologie et d'histocompatibilité, CIB-HOG, AP-HP et IUH, Inserm U940 Hôpital Saint-Louis, Paris, France.
authors.forename: Arij Ben
authors.initials: AB
authors.lastname: Chaaben
authors.affiliation: Laboratoire de biologie clinique, Institut Salah Azaiz, Tunis, Tunisie.
authors.forename: Hajer
authors.initials: H
authors.lastname: Abaza
authors.affiliation: Laboratoire de biologie clinique, Institut Salah Azaiz, Tunis, Tunisie.
authors.forename: Hayet
authors.initials: H
authors.lastname: Douik
authors.affiliation: Laboratoire de biologie clinique, Institut Salah Azaiz, Tunis, Tunisie.
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.affiliation: Laboratoire Jean Dausset d'immunologie et d'histocompatibilité, CIB-HOG, AP-HP et IUH, Inserm U940 Hôpital Saint-Louis, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Charron
authors.affiliation: Laboratoire Jean Dausset d'immunologie et d'histocompatibilité, CIB-HOG, AP-HP et IUH, Inserm U940 Hôpital Saint-Louis, Paris, France.
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Krishnamoorthy
authors.affiliation: Laboratoire de biologie clinique, Institut Salah Azaiz, Tunis, Tunisie.
authors.forename: Fethi
authors.initials: F
authors.lastname: Guemira
authors.affiliation: Laboratoire Jean Dausset d'immunologie et d'histocompatibilité, CIB-HOG, AP-HP et IUH, Inserm U940 Hôpital Saint-Louis, Paris, France.
authors.forename: Ryad
authors.initials: R
authors.lastname: Tamouza
mesh_terms: D002277:Carcinoma / Q000235:genetics / Q000276:immunology*; D059647:Gene-Environment Interaction; D005802:Genes, MHC Class II / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics / Q000276:immunology; D006801:Humans; D055261:Immunogenetic Phenomena; D007157:Immunologic Surveillance / Q000235:genetics / Q000276:immunology; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000276:immunology*
keywords: antitumor surveillance; immunogenetics; inflammation; nasopharyngeal carcinoma