title: CCDC26 gene polymorphism and glioblastoma risk in the Han Chinese population.
abstract: BACKGROUND
  Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 12- 15 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes to formation of glioma, but there are few genetic studies concerning GBM.
  
  
  METHODS
  We genotyped six tagging SNPs (tSNP) in Han Chinese GBM and control patients. We used Microsoft Excel and SPSS 16.0 statistical package for statistical analysis and SNP Stats to test for associations between certain tSNPs and risk of GBM in five different models. ORs and 95%CIs were calculated for unconditional logistic-regression analysis with adjustment for age and gender. The SHEsis software platform was applied for analysis of linkage disequilibrium, haplotype construction, and genetic associations at polymorphism loci.
  
  
  RESULTS
  We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009. The following genotypes of rs891835 were found to be associated with GBM risk in four different models of gene action: i) genotype GT (OR=2.26; 95%CI, 1.29-3.97; p=0.019) or GG (OR=1.33; 95%CI, 0.23-7.81; p=0.019) in the codominant model; ii) genotypes GT and GG (OR=2.18; 95%CI, 1.26-3.78; p=0.0061) in the dominant model; iii) GT (OR=2.24; 95%CI, 1.28-3.92; p=0.0053) in the overdominant model; iv) the allele G of rs891835 (OR=1.85; 95%CI, 1.14-3.00; p=0.015) in the additive model. In addition, "CG" and "CGGAG" were found by haplotype analysis to be associated with increased GBM risk. In contrast, genotype GG of CCDC26 rs6470745 was associated with decreased GBM risk (OR=0.34; 95%CI, 0.12-1.01; p=0.029) in the recessive model.
  
  
  CONCLUSIONS
  Our results, combined with those from previous studies, suggest a potential genetic contribution of CCDC26 to GBM progression among Han Chinese.
authors.affiliation: Department of Neurosurgery, Hanzhong Central Hospital, Hanzhong, China E-mail : gongyk@nwu.edu.cn, cchen898@nwu.edu.cn.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wei
authors.forename: Tian-Bo
authors.initials: TB
authors.lastname: Jin
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Geng
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Chen
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Gao
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Yong-Kuan
authors.initials: YK
authors.lastname: Gong
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding; D055815:Young Adult
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D062085:RNA, Long Noncoding; C000613877:long noncoding RNA CCDC26, human