title: Association between STAT3 gene polymorphisms and Crohn's disease susceptibility: a case-control study in a Chinese Han population.
abstract: BACKGROUND
  Crohn's disease (CD) is an immune-related disease with genetic predisposition. This study aimed to investigate the association of three polymorphisms in the signal transducer and activator of transcription 3 (STAT3) gene with CD risk in a Chinese population.
  
  
  METHODS
  We conducted a hospital-based case-control study involving 232 CD patients and 272 controls. Genotyping was performed using polymerase chain reaction with sequence-specific primer method. Statistical analyses were conducted using logistic regression and genotype risk scoring.
  
  
  RESULTS
  Significant differences were found between patients and controls in allele/genotype distributions of rs744166 (Pallele=0.0008; Pgenotype=0.003) and allele distributions of rs4796793 (P = 0.03). The risk for CD associated with the rs744166-A mutant allele decreased by 37% [95% confidence interval (CI): 0.48-0.83] under the additive model, 39% (95% CI: 0.43-0.81) under the dominant model and 57% (95% CI: 0.24-0.77) under the recessive model. Carriers of the rs4796793-G mutant allele exhibited 25% (95% CI: 0.58-0.98; P=0.03) and 47% (95% CI: 0.30-0.95) decreased risks of developing CD under the additive and recessive models, respectively.
  
  
  CONCLUSIONS
  STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2169674321122294.
authors.forename: Zhengting
authors.initials: Z
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Hongxin
authors.initials: H
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China. Jimmyzj64@medmail.com.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003424:Crohn Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D050796:STAT3 Transcription Factor / Q000235:genetics*; D055815:Young Adult
chemical_list: D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human