title: The difference in translaminar pressure gradient and neuroretinal rim area in glaucoma and healthy subjects.
abstract: Purpose. To assess differences in translaminar pressure gradient (TPG) and neuroretinal rim area (NRA) in patients with normal tension glaucoma (NTG), high tension glaucoma (HTG), and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients). Intraocular pressure (IOP), intracranial pressure (ICP), and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P < 0.05 was considered significant. Results. NTG patients had significantly lower IOP (13.7(1.6) mmHg), NRA (0.97(0.36) mm(2)), comparing with HTG and healthy subjects, P < 0.05. ICP was lower in NTG (7.4(2.7) mmHg), compared with HTG (8.9(1.9) mmHg) and healthy subjects (10.5(3.0) mmHg); however, the difference between groups was not statistically significant (P > 0.05). The difference between TPG for healthy (5.4(7.7) mmHg) and glaucomatous eyes (NTG 6.3(3.1) mmHg, HTG 15.7(7.7) mmHg) was statistically significant (P < 0.001). Higher TPG was correlated with decreased NRA (r = -0.83; P = 0.01) in the NTG group. Conclusion. Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management.
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Eiveniu Street 2, 51368 Kaunas, Lithuania.
authors.forename: Lina
authors.initials: L
authors.lastname: Siaudvytyte
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Eiveniu Street 2, 51368 Kaunas, Lithuania.
authors.forename: Ingrida
authors.identifier: 0000-0002-2660-7922
authors.initials: I
authors.lastname: Januleviciene
authors.affiliation: Telematics Science Laboratory of Kaunas University of Technology, Student ų Street 50, 51368 Kaunas, Lithuania.
authors.forename: Arminas
authors.initials: A
authors.lastname: Ragauskas
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Eiveniu Street 2, 51368 Kaunas, Lithuania ; Telematics Science Laboratory of Kaunas University of Technology, Student ų Street 50, 51368 Kaunas, Lithuania.
authors.forename: Laimonas
authors.identifier: 0000-0001-5835-5697
authors.initials: L
authors.lastname: Bartusis
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Eiveniu Street 2, 51368 Kaunas, Lithuania.
authors.forename: Indre
authors.initials: I
authors.lastname: Meiliuniene
authors.affiliation: Glaucoma Research and Diagnostic Center, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Brent
authors.identifier: 0000-0002-0834-1497
authors.initials: B
authors.lastname: Siesky
authors.affiliation: Eye Clinic, Lithuanian University of Health Sciences, Eiveniu Street 2, 51368 Kaunas, Lithuania ; Glaucoma Research and Diagnostic Center, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Alon
authors.initials: A
authors.lastname: Harris