title: [Evolution of autoantibodies profile in systemic lupus erythematosus according to age and clinical manifestations].
abstract: Clinical features and auto-antibodies profile of 35 Senegalese patients' diagnosed systemic lupus erythematosus (SLE) were analyzed after measurement of antinuclear antibodies (ANA) by IFI, detection of Abs anti-DNA native by ELISA and evaluation of antibodies anti-Sm, anti-RNP, anti-SSA anti-SSB, anti-CCP2, anti-J0, and anti-Scl70 levels by immunodot. Mean age of 33 yrs (18-50 yrs) and sex ratio (F/M) of 16 were found. The most frequent clinical features were rheumatic (88.7%) and cutaneous (79.4%) disorders. ANA and anti-DNAn Abs were detected in 85.7% and 62.5% of the patients respectively. Abs anti-RNP, anti-Sm, anti-SSA, anti-SSB and anti-CCP2 were detected in 30 to 70% of patients. In young patients, the levels of anti-DNAn and anti-Sm Abs were higher than in patients older than 40 yrs (P<0.05). In addition, associations of cutaneous and rheumatic symptoms were characterized by high levels of anti-DNAn, anti-SSA and anti-SSB Abs. Our study shows the interest of a measurement of anti-DNAn, anti-SSA and anti-SSB Abs during the follow of SLE patients particularly in those presenting both rheumatic and cutaneous symptoms.
authors.affiliation: Service d'immunologie UCAD FMPO, Dakar, Sénégal, Service de dermatologie vénérologie, CHU Donka, Guinée.
authors.forename: Mariama Sadjo
authors.initials: MS
authors.lastname: Diallo
authors.affiliation: Service d'immunologie UCAD FMPO, Dakar, Sénégal, Unité d'immunogénétique, Institut Pasteur de Dakar, Sénégal.
authors.forename: Babacar
authors.initials: B
authors.lastname: Mbengue
authors.affiliation: Laboratoire d'analyse médicale, Institut Pasteur de Dakar, Sénégal.
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Seck
authors.affiliation: Service de médecine interne, HALD, Dakar, Sénégal.
authors.forename: Awa Cheikh
authors.initials: AC
authors.lastname: Ndao
authors.affiliation: Service d'immunologie UCAD FMPO, Dakar, Sénégal.
authors.forename: Maguette Sylla
authors.initials: MS
authors.lastname: Niang
authors.affiliation: Service d'immunologie UCAD FMPO, Dakar, Sénégal.
authors.forename: Yacouba
authors.initials: Y
authors.lastname: Cissoko
authors.affiliation: Unité d'immunogénétique, Institut Pasteur de Dakar, Sénégal.
authors.forename: Alassane
authors.initials: A
authors.lastname: Thiam
authors.affiliation: Unité d'immunogénétique, Institut Pasteur de Dakar, Sénégal.
authors.forename: Gora
authors.initials: G
authors.lastname: Diop
authors.affiliation: Unité d'immunogénétique, Institut Pasteur de Dakar, Sénégal.
authors.forename: Rokhaya Ndiaye
authors.initials: RN
authors.lastname: Diallo
authors.affiliation: Service de dermatologie HALD, Dakar, Sénégal.
authors.forename: Moussa
authors.initials: M
authors.lastname: Diallo
authors.affiliation: Service de médecine interne, HALD, Dakar, Sénégal.
authors.forename: Souhaibou
authors.initials: S
authors.lastname: Ndongo
authors.affiliation: Service d'immunologie UCAD FMPO, Dakar, Sénégal.
authors.forename: Tandakha Ndiaye
authors.initials: TN
authors.lastname: Dièye
authors.affiliation: Service de dermatologie vénérologie, CHU Donka, Guinée.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Cissé
authors.affiliation: Service de dermatologie HALD, Dakar, Sénégal.
authors.forename: Assane
authors.initials: A
authors.lastname: Kane
authors.affiliation: Service d'immunologie UCAD FMPO, Dakar, Sénégal, Unité d'immunogénétique, Institut Pasteur de Dakar, Sénégal.
authors.forename: Alioune
authors.initials: A
authors.lastname: Dièye
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000974:Antibodies, Antinuclear / Q000032:analysis; D001168:Arthritis / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006402:Hematologic Diseases / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000276:immunology; D017444:Skin Diseases, Papulosquamous / Q000276:immunology; D055815:Young Adult; D055517:snRNP Core Proteins / Q000032:analysis
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C035356:SS-A antibodies; C035357:SS-B antibodies; D055517:snRNP Core Proteins; D002097:C-Reactive Protein
keywords: anti-DNAn antibody; anti-SSA antibody; anti-SSB antibodies; clinical symptoms; systemic lupus erythematosus