title: A folate receptor-specific activatable probe for near-infrared fluorescence imaging of ovarian cancer.
abstract: We have developed a folate receptor-specific activatable probe for in vivo near-infrared fluorescence imaging of ovarian cancer. This probe becomes highly fluorescent only when its linker is cleaved by a tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
authors.affiliation: Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea. ydchoi@ncc.re.kr.
authors.forename: Hawon
authors.initials: H
authors.lastname: Lee
authors.forename: Jisu
authors.initials: J
authors.lastname: Kim
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Kim
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Kim
authors.forename: Yongdoo
authors.initials: Y
authors.lastname: Choi
mesh_terms: D000818:Animals; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism*; D058973:Folate Receptors, GPI-Anchored / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D005456:Fluorescent Dyes; D058973:Folate Receptors, GPI-Anchored