title: Sequential direct SNAr reactions of pentafluorobenzenes with azole or indole derivatives.
abstract: Sequential regioselective N-arylations through high-yielding catalyst-free direct SNAr reactions of pentafluorobenzene derivatives with azole or indole derivatives are described. The N-arylated derivatives were further functionalized through a microwave-assisted cross-coupling reaction via C-H bond activation or Suzuki conditions. The order of the reactions could be reversed, proving full orthogonality between the reactions which led to well-defined fully substituted benzene derivatives.
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Frederik
authors.initials: F
authors.lastname: Diness
authors.forename: Mikael
authors.initials: M
authors.lastname: Begtrup
mesh_terms: D001393:Azoles / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D005464:Fluorobenzenes / Q000737:chemistry*; D006860:Hydrogen Bonding; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001393:Azoles; D001555:Benzene Derivatives; D005464:Fluorobenzenes; D007211:Indoles; C030374:indole