title: Identification and bioactivity of 3-epi-xestoaminol C isolated from the New Zealand brown alga Xiphophora chondrophylla.
abstract: We report here the bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-xestoaminol C (1), isolated from the New Zealand brown alga Xiphophora chondrophylla. This is the first report of a 1-deoxysphingoid from a brown alga. We describe the isolation and full structure elucidation of this compound, including its absolute configuration, along with its bioactivity against mycobacteria and mammalian cell lines and preliminary mechanism of action studies using yeast chemical genomics.
authors.affiliation: Center for Biodiscovery and School of Biological Sciences, Victoria University of Wellington , PO Box 600, Kelburn, Wellington 6140, New Zealand.
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Dasyam
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Munkacsi
authors.forename: Nazmi H
authors.initials: NH
authors.lastname: Fadzilah
authors.forename: Dinindu S
authors.initials: DS
authors.lastname: Senanayake
authors.forename: Ronan F
authors.initials: RF
authors.lastname: O'Toole
authors.forename: Robert A
authors.initials: RA
authors.lastname: Keyzers
mesh_terms: D000818:Animals; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009520:New Zealand; D000459:Phaeophyceae / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C000591087:3-epi-xestoaminol C; D005233:Fatty Alcohols; C476391:xestoaminol C