title: Combining photoredox-catalyzed trifluoromethylation and oxidation with DMSO: facile synthesis of α-trifluoromethylated ketones from aromatic alkenes.
abstract: Trifluoromethylated ketones are useful building blocks for organic compounds with a trifluoromethyl group. A new and facile synthesis of ketones with a trifluoromethyl substituent in the α-position proceeds through a one-pot photoredox-catalyzed trifluoromethylation-oxidation sequence of aromatic alkenes. Dimethyl sulfoxide (DMSO) serves as a key and mild oxidant under these photocatalytic conditions. Furthermore, an iridium photocatalyst, fac[Ir(ppy)3 ] (ppy=2-phenylpyridine), turned out to be crucial for the present photoredox process.
authors.affiliation: Chemical Resources Laboratory, Tokyo Institute of Technology, R1-27, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503 (Japan) http://www.res.titech.ac.jp/∼smart/smart_e.html.
authors.forename: Ren
authors.initials: R
authors.lastname: Tomita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yasu
authors.forename: Takashi
authors.initials: T
authors.lastname: Koike
authors.forename: Munetaka
authors.initials: M
authors.lastname: Akita
keywords: carbocations; fluorine; homogeneous catalysis; oxidation; photochemistry