title: [Cytokine-mediated bone resorption].
abstract: Osteoclasts, the multinucleated cells that resorb bone, originate from monocyte-macrophage lineage cells. Various hormones, cytokines and growth factors are involved in osteoclastogenesis, via interaction with osteoblasts. In this review, we summarize the regulatory mechanism of bone resorption by various cytokines derived from osteoblasts and hematopoietic inflammatory cells.
authors.affiliation: Department of Biochemistry, Institute for Oral Science, Matsumoto Dental University, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Nakamura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Uehara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Udagawa
mesh_terms: D001862:Bone Resorption / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D016207:Cytokines / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D020381:Interleukin-17 / Q000502:physiology; D020382:Interleukin-18 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology; D010006:Osteoblasts; D010010:Osteoclasts / Q000166:cytology*; D010012:Osteogenesis / Q000235:genetics; D053244:Osteoprotegerin / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology; D000071818:Wnt-5a Protein
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D020381:Interleukin-17; D020382:Interleukin-18; D015850:Interleukin-6; D053244:Osteoprotegerin; D011518:Proto-Oncogene Proteins; D053245:RANK Ligand; D014409:Tumor Necrosis Factor-alpha; C085389:WNT5A protein, human; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D016173:Macrophage Colony-Stimulating Factor; D015232:Dinoprostone