title: Modulatory effects of curcumin on redox status, mitochondrial function, and caspace-3 expression during atrazin-induced toxicity.
abstract: Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity was induced by oral administration of atrazine (400 mg/kg/day) for 3 weeks. Curcumin at a dose of 400 mg/kg/day was given simultaneously by oral route. Redox status, mitochondrial function, 8-hydroxydeoxyguanosine (8-OHdG) level by immunoassay, and caspace-3 expression by immunohistochemistry were evaluated. Curcumin showed significant cardiac protection with improvement of redox status, mitochondrial function, 8-OHdG level, caspase-3 immunoreactivity, and cardiac muscle degeneration. From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Walaa A
authors.initials: WA
authors.lastname: Keshk
authors.forename: Nema A
authors.initials: NA
authors.lastname: Soliman
authors.forename: Mona M
authors.initials: MM
authors.lastname: Abo El-Noor
authors.forename: Amira A
authors.initials: AA
authors.lastname: Wahdan
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Shareef
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001280:Atrazine / Q000633:toxicity; D053148:Caspase 3 / Q000096:biosynthesis*; D003474:Curcumin / Q000008:administration & dosage*; D005786:Gene Expression Regulation; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats
chemical_list: D000975:Antioxidants; D053148:Caspase 3; D003474:Curcumin; D001280:Atrazine
keywords: Atrazine; Caspase-3; Curcumin; Mitochondrial Function; Oxidant/Antioxidant Status