title: How to build segregation complexes in bacteria: Use bridges.
abstract: In this issue of Genes & Development, Graham and colleagues (pp. 1228-1238) examine how ParBs, which bind to prokaryotic centromere-like partition sites, spread into nearby nonspecific DNA and assemble into higher-order protein-DNA complexes. Spreading is accomplished by looping rather than one-dimensional filamentation, thereby compacting the DNA into an extensively bridged complex.
authors.affiliation: Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Funnell
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism*; D019915:DNA Primase / Q000378:metabolism*; D004269:DNA, Bacterial / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D019915:DNA Primase
keywords: ParB; Spo0J; bacterial chromosome segregation; single-molecule fluorescence