title: miRNAs at the interface of cellular stress and disease.
abstract: microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Anna
authors.initials: A
authors.lastname: Emde
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel eran.hornstein@weizmann.ac.il.
authors.forename: Eran
authors.initials: E
authors.lastname: Hornstein
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D035683:MicroRNAs
keywords: cellular stress; dicer; disease; micrornas; stress granules