title: ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
abstract: ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.
authors.affiliation: Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA ; Department of Orthopaedic Surgery, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Jianlu
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA.
authors.forename: Brendon
authors.initials: B
authors.lastname: Richbourgh
authors.affiliation: Department of Orthopaedic Surgery, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Tanghong
authors.initials: T
authors.lastname: Jia
authors.affiliation: Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA ; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Chuanju
authors.initials: C
authors.lastname: Liu
mesh_terms: D051722:ADAM Proteins / Q000502:physiology*; D000071096:ADAMTS Proteins; D000818:Animals; D001168:Arthritis / Q000201:enzymology*; D001172:Arthritis, Rheumatoid / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006066:Gonads / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D045726:Metalloproteases / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D018345:Mice, Knockout; D010003:Osteoarthritis / Q000201:enzymology; D017434:Protein Structure, Tertiary; D012559:Schizophrenia / Q000201:enzymology; D014327:Trophoblasts / Q000473:pathology
chemical_list: D045726:Metalloproteases; D051722:ADAM Proteins; D000071096:ADAMTS Proteins; C496252:ADAMTS12 protein, human; C550048:Adamts12 protein, mouse