title: Systems biology approaches to develop innovative strategies for lung cancer therapy.
abstract: Lung cancer (LC) is a number one killer of cancer-related death among men and women worldwide. Major advances have been made in the diagnosis, staging and use of surgery for LC, but systemic chemotherapy and radiotherapy alone or in combination with some targeted agents remains the core treatment of advanced LC. Unfortunately, in spite of improved diagnosis, surgical methods and new treatments, mortality is still extremely high among LC patients. To understand the precise functioning of signaling pathways associated with resistance to current treatments in LC, as well as to identify novel treatment regimens, a holistic approach to analyze signaling networks should be applied. Here, we describe systems biology-based approaches to generate biomarkers and novel therapeutic targets in LC, as well as how this may contribute to personalized treatment for this malignancy.
authors.affiliation: Department of Oncology-Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm SE-171 76, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Viktorsson
authors.affiliation: Department of Oncology-Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm SE-171 76, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Lewensohn
authors.affiliation: 1] Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, Stockholm SE-171 77, Sweden [2] Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow 117192, Russia.
authors.forename: B
authors.initials: B
authors.lastname: Zhivotovsky
mesh_terms: D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D057285:Precision Medicine / Q000379:methods*; D049490:Systems Biology / Q000379:methods*