title: Voriconazole associated torsades de pointes in two adult patients with haematological malignancies.
abstract: Voriconazole can prolong the QT interval contributing to life-threatening cardiac arrhythmia. Torsades de pointes is an uncommon but serious complication of voriconazole use which may be under-recognised. We present torsades de pointes in two patients with underlying haematological malignancy being treated for invasive fungal infection with voriconazole. Patients receiving voriconazole should be screened and monitored for evidence of QT prolongation, and if prolongation detected, consideration given to alternative treatments or more intensive cardiac monitoring.
authors.affiliation: Eastern Health, Department of Infectious Diseases, Nelson Rd., Box Hill, Victoria 3128, Australia.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Brown
authors.affiliation: Eastern Health, Department of Infectious Diseases, Nelson Rd., Box Hill, Victoria 3128, Australia.
authors.forename: Lyn-Li
authors.initials: LL
authors.lastname: Lim
authors.affiliation: Eastern Health, Department of Pharmacy, Nelson Rd., Box Hill, Victoria 3128, Australia.
authors.forename: Sonia
authors.initials: S
authors.lastname: Koning
keywords: Arrhythmia; QTc; Torsades de pointes; Voriconazole