title: Effect of active Notch signaling system on the early repair of rat sciatic nerve injury.
abstract: It is all known that dedifferentiated Schwann cells (SCs) play an important role in neural regeneration, and Notch signaling has complex and extensive regulatory functions in dedifferentiated SCs. So studies have focused on how to improve peripheral nerve repair by regulating proliferation and dedifferentiation in SCs with Notch signaling meloculars.We have found SCs can be activated when adding Recombinant rat jagged1/FC chimera (an activator of the Notch signaling system) in vivo. Compared with that of the control groups, at 4 weeks post-surgery nerve regeneration and functional rehabilitation in the Recombinant rat jagged1/FC chimera group were advanced significantly, and the expression of neurotrophic factors in the regenerated nerves was elevated largely. These results indicated that SCs activated by Notch signaling could promote nerve repair effectively in the early regenerative stage, suggesting the possible clinical application for the treatment of peripheral nerve defects.
authors.affiliation: a Department of Pathology , Medical College, Qing Dao University , Qing Dao , P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: b The Affiliated Hospital of Medical College, Qing Dao University , Qing Dao , P. R. China.
authors.forename: Ke-Yu
authors.initials: KY
authors.lastname: Ren
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Wang
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Kou
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Pei-Xun
authors.initials: PX
authors.lastname: Zhang
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Peng
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Deng
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Zhang
authors.affiliation: c Department of Trauma and Orthopedics , People's Hospital, Peking University , Beijing , P. R. China.
authors.forename: Bao-Guo
authors.initials: BG
authors.lastname: Jiang
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D000072100:Jagged-1 Protein; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism; D020932:Nerve Growth Factor / Q000235:genetics / Q000378:metabolism; D009416:Nerve Regeneration / Q000187:drug effects* / Q000235:genetics; D059348:Peripheral Nerve Injuries / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D051881:Receptor, Notch1 / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D012583:Schwann Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries / Q000378:metabolism*; D000072099:Serrate-Jagged Proteins; D015398:Signal Transduction; D000072056:Transcription Factor HES-1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D019208:Brain-Derived Neurotrophic Factor; D002135:Calcium-Binding Proteins; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; D020932:Nerve Growth Factor; D051881:Receptor, Notch1; D011994:Recombinant Proteins; D000072099:Serrate-Jagged Proteins; D000072056:Transcription Factor HES-1; C489735:Hes1 protein, rat; C000606275:Jag1 protein, rat; C497763:Notch1 protein, rat
keywords: Notch signaling; nerve regeneration; schwann cells; sciatic nerve