title: Urine metabolomic profiling in neonatal nephrology.
abstract: Metabolomics, the latest "omics" technology aims to study the complete set of low molecular weight metabolites that may change according to the physiological or the pathological state of the organism. Clinical studies dealing with metabolomics in neonatal and pediatric nephrology are very few. In this paper we present the experimental studies in newborn animal models, together with the available data on human newborns. Finally the urine metabolomic profiling of 3 newborns who suffered from severe perinatal asphyxia and were treated with hypothermia. They are located in a different part of the multivariate space, the reason of the differences being the basal metabolic profile (resilience) of each neonate: 1 died and 2 survived (one of them developed an acute kidney injury). The main metabolites responsible for the different metabolic profile among the 3 newborns are presented. In the future each neonatologist and nephrologist should become skilled in the metabolomic field.
authors.affiliation: Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Italy. Electronic address: vafanos@tiscali.it.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
authors.affiliation: Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Noto
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Caboni
authors.affiliation: Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Pintus
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Liori
authors.affiliation: Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Italy.
authors.forename: Angelica
authors.initials: A
authors.lastname: Dessì
authors.affiliation: Department of Laboratory Medicine, IRCCS AOU San Martino - IST, University-Hospital Genoa, Genoa 16132, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Mussap
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000175:diagnosis* / Q000652:urine; D055442:Metabolome; D015997:Neonatal Screening; D016482:Urinalysis
chemical_list: D015415:Biomarkers
keywords: Children; Kidney; Metabolomics; Nephrology; Newborn