title: Chinese traditional medicine and adult neurogenesis in the hippocampus.
abstract: Adult neurogenesis is an important therapeutic target in treating neurological disorders. Adult neurogenesis takes place in two regions of the brain: Subventricular zone and dentate gyrus in the hippocampus. The progressive understanding on hippocampal neurogenesis in aging and mood disorders increases the demand to explore powerful and subtle interventions on hippocampal neurogenesis. Traditional Chinese herbal medicine provides an abundant pharmaceutical platform for modulating hippocampal neurogenesis. Recent progress in exploring the effects of Chinese herbal medicine and the related mechanisms opens a new direction for regeneration therapy. The current review gives a thorough summary of the research progress made in traditional Chinese herbal formulas, and the effective compounds in Chinese herbs which are beneficial on hippocampal neurogenesis and the possible mechanisms involved.
authors.affiliation: Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. ; Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Endong
authors.initials: E
authors.lastname: Zhang
authors.affiliation: School of Chinese Medicine, Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. ; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. ; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China. ; GHM Institute of CNS Regeneration, and Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China.
authors.forename: Kwok Fai
authors.initials: KF
authors.lastname: So
keywords: Active components; Hippocampal neurogenesis; Neural progenitor cells; Traditional Chinese herb