title: Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.
abstract: Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.
authors.affiliation: Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Mattison
authors.affiliation: Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Mingyi
authors.initials: M
authors.lastname: Wang
authors.affiliation: Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Michel
authors.initials: M
authors.lastname: Bernier
authors.affiliation: Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Park
authors.affiliation: Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Maudsley
authors.affiliation: Program in Respiratory Biology and Lung Disease, Johns Hopkins Bloomberg School of Public Health, Room E7616, 615 North Wolfe Street, Baltimore, MD 21205, USA.
authors.forename: Steven S
authors.initials: SS
authors.lastname: An
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Ross 1150, 720 Rutland Avenue, Baltimore, MD 21205, USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Santhanam
authors.affiliation: Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Bronwen
authors.initials: B
authors.lastname: Martin
authors.affiliation: Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Shakeela
authors.initials: S
authors.lastname: Faulkner
authors.affiliation: Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA; Mathematics and Statistics Department, Loyola University Maryland, Baltimore, MD 21210, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Morrell
authors.affiliation: Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Room 12-114, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Baur
authors.affiliation: Systems Biology, Harvard Medical School, WA 536, Boston, MA 02115, USA.
authors.forename: Leonid
authors.initials: L
authors.lastname: Peshkin
authors.affiliation: Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma, BRC 1303, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA.
authors.forename: Danuta
authors.initials: D
authors.lastname: Sosnowska
authors.affiliation: Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma, BRC 1303, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Csiszar
authors.affiliation: National Institute of Allergy and Infectious Disease, NIH Animal Center, Building 102, 16701 Elmer School Road, Dickerson, MD 20842, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Herbert
authors.affiliation: Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Tilmont
authors.affiliation: Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma, BRC 1303, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Ungvari
authors.affiliation: Department of Pharmacology and Nutritional Sciences, University of Kentucky, C.T. Wethington Building, Room 591, 900 South Limestone, Lexington, KY 40536, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Pearson
authors.affiliation: Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
authors.forename: Edward G
authors.initials: EG
authors.lastname: Lakatta
authors.affiliation: Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address: decabora@mail.nih.gov.
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
mesh_terms: D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D059305:Diet, High-Fat; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D011323:Primates; D063177:Pulse Wave Analysis; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013395:Sucrose / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000447:Aldehydes; D013267:Stilbenes; D013395:Sucrose; D053148:Caspase 3; C027576:4-hydroxy-2-nonenal; D000077185:Resveratrol