title: Decrease of muscle volume in chronic kidney disease: the role of mitochondria in skeletal muscle.
abstract: Reduced muscle volume and impaired exercise endurance are well-documented phenomena in chronic kidney disease, and the relevant molecular mechanisms have been gradually unveiled. Tamaki et al. demonstrate a reduction of mitochondria content in skeletal muscles as a novel mechanism of reduced exercise endurance in renal insufficiency. In addition, they show that a high-protein diet reduces exercise endurance through an inhibition of muscle pyruvate dehydrogenase.
authors.affiliation: Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yokoi
authors.affiliation: Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Yanagita
mesh_terms: D000818:Animals; D004044:Dietary Proteins / Q000009:adverse effects*; D017079:Exercise Tolerance; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology*; D063269:Mitochondrial Turnover; D018482:Muscle, Skeletal / Q000201:enzymology*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000201:enzymology*
chemical_list: D004044:Dietary Proteins; D011768:Pyruvate Dehydrogenase Complex