title: Pd/NHC-catalyzed enantiospecific and regioselective Suzuki-Miyaura arylation of 2-arylaziridines: synthesis of enantioenriched 2-arylphenethylamine derivatives.
abstract: A palladium-catalyzed stereospecific and regioselective cross-coupling of enantiopure 2-arylaziridines with arylboronic acids under mild conditions to construct a tertiary stereogenic center has been developed. N-heterocyclic carbene (NHC) ligands efficiently promote the coupling, suppressing β-hydride elimination. The enantiospecific cross-coupling allowed us for preparation of a series of biologically important 2-arylphenethylamine derivatives in an enantiopure form.
authors.affiliation: Frontier Research Base for Global Young Researchers and ‡Department of Applied Chemistry, Graduate School of Engineering, Osaka University , Yamadaoka 2-1, Suita, Osaka 565-0871, Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Akinobu
authors.initials: A
authors.lastname: Kuroda
authors.forename: Shino
authors.initials: S
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Minakata