title: Two new sesquiterpenes from Artemisia sieversiana.
abstract: Two new sesquiterpenes, together with 32 known compounds(3-34), were isolated from Artemisia sieversiana Ehrhart ex willd. and the compounds 3-21 were isolated from this plant for the first time. The new compounds were elucidated as 2α,9α-dihydroxymuurol-3(4)-en-12-oic acid (1) and 13α-methyl-(5αH,6αH,7αH,8αH)-austricin 8-O-β-D-glucopyranoside (2), respectively. The structural identification of these compounds was mainly achieved by spectroscopic methods including 1D and 2D NMR techniques, and the structure of compound 1 was confirmed by a single crystal X-ray diffraction experiment. Compounds 1-2 were evaluated for cytotoxic activity in vitro against MCF-7, NCI-H460 and Hep-G2 cell lines, respectively.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China; Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, PR China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China; Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, PR China. Electronic address: zxliao@seu.edu.cn.
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liao
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China.
authors.forename: Lan-Ju
authors.initials: LJ
authors.lastname: Ji
authors.affiliation: Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China.
authors.forename: Hong-Fa
authors.initials: HF
authors.lastname: Sun
mesh_terms: D019306:Artemisia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C000596991:2,9-dihydroxymuurol-3(4)-en-12-oic acid; D012717:Sesquiterpenes
keywords: Artemisia sieversiana; Compositae; Cytotoxic activity; Flavone; Lignan; Sesquiterpene