title: Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration.
abstract: Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.
authors.affiliation: Faculty of Dentistry, National University of Singapore, 11 Lower Kent Ridge Road, Singapore, 119083, Singapore, dentohws@nus.edu.sg.
authors.forename: Wei Seong
authors.initials: WS
authors.lastname: Toh
authors.forename: Casper Bindzus
authors.initials: CB
authors.lastname: Foldager
authors.forename: Ming
authors.initials: M
authors.lastname: Pei
authors.forename: James Hoi Po
authors.initials: JH
authors.lastname: Hui
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology* / Q000293:injuries; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012038:Regeneration; D014945:Wound Healing