title: Surgery for reflux induced airway disease: a systematic review.
abstract: OBJECTIVE
  1. Evaluate the current evidence regarding the efficacy and safety of anti-reflux surgery for the treatment of severe gastroesophageal reflux-related airway disease in children. 2. Provide evidence based recommendations regarding indications and outcomes of anti-reflux surgery for airway disease in children.
  
  
  METHODS
  An a priori protocol was defined to identify all articles addressing anti-reflux surgery for the treatment of reflux-related airway disease in children where details regarding the diagnosis, treatment, and outcomes were clearly presented. The search was inclusive of all references available through August 30, 2013 and included electronic databases to identify candidate articles as well as a comprehensive series of crosschecks. The two authors independently determined which references met inclusion criteria, extracted data, and assigned levels of evidence. Data were pooled using a random effects model due to significant study heterogeneity.
  
  
  RESULTS
  Fourteen articles met inclusion criteria. The overall level of evidence was grade C. There was significant heterogeneity among the studies (I(2)=82.7%; p<0.001). However, each article uniformly presented cases suggesting that anti-reflux surgery is efficacious and safe in treating children with severe reflux-related respiratory disease. The pooled success rate for complete or partial resolution of symptoms after anti-reflux surgery was 0.91 (95% CI: 0.88, 0.94). The pooled success rate for complete symptom resolution after surgery was 0.72 (95% CI: 0.62, 0.83).
  
  
  CONCLUSIONS
  The current literature suggests that anti-reflux surgery is an effective and safe treatment for severe reflux-related airway disease. However, the level of evidence lacks strength and further investigation is warranted.
authors.affiliation: Naval Medical Center San Diego, Department of Otolaryngology - Head and Neck Surgery, San Diego, CA, 92134, United States.
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Sload
authors.affiliation: Naval Medical Center San Diego, Department of Otolaryngology - Head and Neck Surgery, San Diego, CA, 92134, United States. Electronic address: matt.brigger@alumni.vanderbilt.edu.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Brigger
mesh_terms: D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000601:surgery*; D006801:Humans; D012120:Respiration Disorders / Q000209:etiology; D012135:Respiratory Sounds / Q000209:etiology
keywords: ALTE; Airway disease; Anti-reflux surgery; Gastroesophageal reflux; Nissen