title: Anti-tumor activities of Au(I) complexed with bisphosphines in HL-60 cells.
abstract: We found that Au(I) complexed with 2,3-bis(tert-butyl(methyl)phosphino) quinoxaline (10) was a potent anti-tumor agent (half-maximal growth inhibitory concentration, GI50=0.87μM) with broad anti-tumor activity. In particular, the activity of complex 10 was high in tumor cell lines derived from the colon and ovary. Treatment with complex 10 resulted in the apoptosis of HL-60 cells. The ligand for the preparation of complex 10 is commercially available implying that complex 10 might be a good drug candidate for cancer therapy.
authors.affiliation: Department of Chemistry, Graduate School of Science and Engineering, Saga University, 1 Honjo-machi, Saga 8408502, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Hayashi
authors.affiliation: Nippon Chemical Industrial Co. Ltd., 9-11-1 Kameido, Koto-ku, Tokyo 136-8515, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakatsui
authors.affiliation: Department of Chemistry, Graduate School of Science and Engineering, Saga University, 1 Honjo-machi, Saga 8408502, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sugiyama
authors.affiliation: Department of Chemistry, Graduate School of Science and Engineering, Saga University, 1 Honjo-machi, Saga 8408502, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kitajima
authors.affiliation: Nippon Chemical Industrial Co. Ltd., 9-11-1 Kameido, Koto-ku, Tokyo 136-8515, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Oohara
authors.affiliation: Nippon Chemical Industrial Co. Ltd., 9-11-1 Kameido, Koto-ku, Tokyo 136-8515, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugiya
authors.affiliation: Department of Chemistry, Graduate School of Science and Engineering, Saga University, 1 Honjo-machi, Saga 8408502, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Osada
authors.affiliation: Department of Chemistry, Graduate School of Science and Engineering, Saga University, 1 Honjo-machi, Saga 8408502, Japan. Electronic address: hiroaki@cc.saga-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kodama
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002219:Carbamates / Q000008:administration & dosage / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000188:drug therapy; D011763:Pyrrolizidine Alkaloids / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D002219:Carbamates; D011763:Pyrrolizidine Alkaloids; C013697:synthanecine A-bis(N-ethylcarbamate); D006046:Gold
keywords: 2,3-bis(tert-butyl(methyl)phosphino) quinoxaline; Anti-tumor activity; Au(I) complex