title: Management of the clinically node-negative axilla in primary and locally recurrent breast cancer.
abstract: For patients with primary breast cancer, nodal status remains a key determinant for overall prognosis. Sentinel lymph node biopsy (SLNB) has become standard care for staging patients who have clinically node-negative disease. However, a new dilemma has arisen: how to manage the clinically negative axilla in patients with ipsilateral breast tumor recurrences (IBTRs). Are outcomes in these patients improved with repeat SLNB? Although observational studies suggest SLNB is feasible in patients with IBTR and a clinically node-negative axilla, the overall impact on morality and local recurrence is not yet known as no randomized trials have addressed this issue.
authors.affiliation: Department of Surgery, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, MC 7738, San Antonio, TX 78229-3900, USA.
authors.forename: Ashley C
authors.initials: AC
authors.lastname: McGinity
authors.affiliation: Department of Surgery, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, MC 7738, San Antonio, TX 78229-3900, USA.
authors.forename: Meeghan A
authors.initials: MA
authors.lastname: Lautner
authors.affiliation: Department of Surgery, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, MC 7738, San Antonio, TX 78229-3900, USA. Electronic address: jatoi@uthscsa.edu.
authors.forename: Ismail
authors.initials: I
authors.lastname: Jatoi
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D061305:Lymphoscintigraphy; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D021701:Sentinel Lymph Node Biopsy
keywords: Axilla; Breast cancer; Recurrence; Sentinel lymph node