title: Using inflammatory and oxidative biomarkers in urine to predict early acute kidney injury in patients undergoing liver transplantation.
abstract: OBJECTIVE
  We examined the value of inflammatory and oxidative biomarkers in predicting acute kidney injury (AKI) following orthotopic liver transplantation (OLT).
  
  
  METHODS
  Urinary excretion of tumour necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10), superoxide dismutase (SOD), malondialdehyde (MDA), 6-keto prostaglandin F1α (6-keto-PGF1α), hydrogen peroxide (H2O2), and 8-keto prostaglandin F2α (8-iso-PGF2α), serum creatinine (SCr), blood urea nitrogen (BUN), urinary N-acetyl-beta-D-glucosaminidase (NAG), β2-microglobulin (β2-MG) and γ-glutamyl-transferase (γ-GT), were measured before surgery (baseline), at 2 h after graft reperfusion and 24 h after OLT in 28 liver transplantation patients.
  
  
  RESULTS
  The levels of TNF-α, IL-8, IL-10, SOD, MDA, 6-keto-PGF1α, H2O2 and 8-iso-PGF2α in urine were all significantly higher in patients who had AKI than in those who did not at 2 h after graft reperfusion and 24 h after OLT (p < 0.01).
authors.affiliation: Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University , Tianhe district, Guangzhou City , China.
authors.forename: Dezhao
authors.initials: D
authors.lastname: Liu
authors.forename: Pinjie
authors.initials: P
authors.lastname: Huang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Li
authors.forename: Mian
authors.initials: M
authors.lastname: Ge
authors.forename: Gangjian
authors.initials: G
authors.lastname: Luo
authors.forename: Ziqing
authors.initials: Z
authors.lastname: Hei
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000652:urine*; D000328:Adult; D015415:Biomarkers / Q000652:urine*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000652:urine; D016753:Interleukin-10 / Q000652:urine; D016209:Interleukin-8 / Q000652:urine; D016031:Liver Transplantation; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D011379:Prognosis; D012372:ROC Curve; D013482:Superoxide Dismutase / Q000652:urine; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000652:urine
chemical_list: D015415:Biomarkers; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; C075750:8-epi-prostaglandin F2alpha; D008315:Malondialdehyde; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase
keywords: Acute kidney injury (AKI); inflammation; orthotopic liver transplantation (OLT); oxidative stress; urinary biomarkers