title: Association of recent exposure to ambient metals on fractional exhaled nitric oxide in 9-11 year old inner-city children.
abstract: Exposure to ambient metals in urban environments has been associated with wheeze, and emergency room visits and hospitalizations due to respiratory illness. However, the effect of ambient metals exposure on airway inflammation, and how these associations may be modified by seroatopy, has not been determined. Fractional exhaled nitric oxide (FENO) is a reliable proxy marker of airway inflammation. We hypothesized that recent ambient concentrations of Ni, V, Zn and Fe would be associated differentially with proximal and distal fractions of exhaled NO, and that these associations would be modified by seroatopy. As part of the Columbia Center for Children's Environmental Health (CCCEH) birth cohort study, 9-11 year old children (n=192) were evaluated. Ambient measures of Ni, V, Zn and Fe were obtained from a local central monitoring site and averaged over 9 days based on three 24h measures every third day. Fractional exhaled nitric oxide (FENO) samples were obtained at constant flows of 50 (FENO50), 83 and 100mL/s, and used to determine surrogate measures for proximal (JNO) and alveolar (Calv) inflammation. Seroatopy was determined by specific IgE at age 7. Data were analyzed using multivariable linear regression. Ambient V and Fe concentrations were associated positively with FENO50 (p=0.018, p=0.027). Ambient Fe was associated positively with JNO (p=0.017). Ambient Ni and V concentrations were associated positively with Calv (p=0.004, p=0.018, respectively). A stronger association of Ni concentrations with Calv was observed among the children with seroatopy. These results suggest that ambient metals are associated differentially with different fractions of FENO production, and this relationship may be modified by seroatopy.
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States. Electronic address: maria.rosa@mssm.edu.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Rosa
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States. Electronic address: mp2217@columbia.edu.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Perzanowski
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States. Electronic address: ad708@columbia.edu.
authors.forename: Adnan
authors.initials: A
authors.lastname: Divjan
authors.affiliation: Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY, United States. Electronic address: chilli@ldeo.columbia.edu.
authors.forename: Steven N
authors.initials: SN
authors.lastname: Chillrud
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States. Electronic address: hoepner@nyspi.columbia.edu.
authors.forename: Lori
authors.initials: L
authors.lastname: Hoepner
authors.affiliation: Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, United States. Electronic address: hz2243@columbia.edu.
authors.forename: Hanjie
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, United States. Electronic address: rmr2161@columbia.edu.
authors.forename: Robert
authors.initials: R
authors.lastname: Ridder
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States. Electronic address: fpp1@columbia.edu.
authors.forename: Frederica P
authors.initials: FP
authors.lastname: Perera
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States; Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, United States; Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, United States. Electronic address: rlm14@columbia.edu.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Miller
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D000075322:Heavy Metal Poisoning; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D016014:Linear Models; D008297:Male; D019216:Metals, Heavy / Q000008:administration & dosage* / Q000009:adverse effects* / Q000032:analysis; D009569:Nitric Oxide / Q000378:metabolism*; D011247:Pregnancy; D012137:Respiratory System / Q000187:drug effects; D055815:Young Adult
chemical_list: D019216:Metals, Heavy; D009569:Nitric Oxide
keywords: Alveolar NO; Ambient metals; Asthma; Bronchial flux; FENO; Seroatopy