title: Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75.
abstract: In this study, we evaluated, in the mouse, the effects of 20 mg/kg i.p. daily administration for 15 consecutive days of a blend of polyphenols, containing mostly oleuropein, extracted from the olive leaves (Olea europaea) on brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and on the expression of their receptors, TrkA, TrkB and p75. Polyphenols decreased the levels of reduced glutathione (GSH) and increased the levels of NGF and BDNF in the serum. In the brain, we found decreased levels of NGF and BDNF in the hippocampus and striatum but elevated levels of NGF in the olfactory lobes and hypothalamus and again BDNF potentiation in the olfactory lobes. No changes in TrkA, TrkB and p75 expression were observed. In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.
authors.affiliation: a Institute of Cellular Biology and Neurobiology, National Research Council (CNR) , via del Fosso di Fiorano 64, 00143 Rome , Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Carito
authors.forename: Alessandro
authors.initials: A
authors.lastname: Venditti
authors.forename: Armandodoriano
authors.initials: A
authors.lastname: Bianco
authors.forename: Mauro
authors.initials: M
authors.lastname: Ceccanti
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Serrilli
authors.forename: George
authors.initials: G
authors.lastname: Chaldakov
authors.forename: Luigi
authors.initials: L
authors.lastname: Tarani
authors.forename: Sara
authors.initials: S
authors.lastname: De Nicolò
authors.forename: Marco
authors.initials: M
authors.lastname: Fiore
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000187:drug effects*; D005978:Glutathione / Q000032:analysis / Q000097:blood / Q000187:drug effects; D057888:Iridoid Glucosides; D039823:Iridoids / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D023421:Models, Animal; D020932:Nerve Growth Factor / Q000187:drug effects; D009414:Nerve Growth Factors / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D031658:Olea / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols / Q000008:administration & dosage / Q000494:pharmacology*; D020917:Receptor, trkA / Q000187:drug effects*; D020813:Receptor, trkB / Q000187:drug effects*; D017475:Receptors, Nerve Growth Factor / Q000187:drug effects*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D057888:Iridoid Glucosides; D039823:Iridoids; D009414:Nerve Growth Factors; D059808:Polyphenols; D017475:Receptors, Nerve Growth Factor; C002769:oleuropein; D020932:Nerve Growth Factor; D020917:Receptor, trkA; D020813:Receptor, trkB; D005978:Glutathione
keywords: BDNF; NGF; olive; polyphenols