title: Thielavialides A-E, nor-spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, an endophytic fungus isolated from aeroponically grown Physalis alkekengi.
abstract: Four new nor-spiro-azaphilones, thielavialides A-D (1- 4), a new bis-spiro-azaphilone, thielavialide E (5), together with pestafolide A (6), were isolated from the endophytic fungal strain, Thielavia sp. PA0001, occurring in the healthy leaf tissue of aeroponically grown Physalis alkekengi. The structures and relative configurations of 1-5 were established on the basis of their MS and NMR data. Possible biosynthetic pathways to thielavialides A-E (1- 5) from pestafolide A (6), some involving a Favorskii-like rearrangement, are proposed.
authors.affiliation: Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona , 250 East Valencia Road, Tucson, Arizona 85706, United States.
authors.forename: E M Kithsiri
authors.initials: EM
authors.lastname: Wijeratne
authors.forename: Patricia
authors.initials: P
authors.lastname: Espinosa-Artiles
authors.forename: Raphael
authors.initials: R
authors.lastname: Gruener
authors.forename: A A Leslie
authors.initials: AA
authors.lastname: Gunatilaka
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D005658:Fungi / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032321:Physalis / Q000382:microbiology*; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification*; D018515:Plant Leaves / Q000382:microbiology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D001578:Benzopyrans; D010860:Pigments, Biological; D013141:Spiro Compounds; C494154:azaphilone