title: Bone marrow metastasis in primary bronchial mucoepidermoid carcinoma: a case report.
abstract: Primary bronchial mucoepidermoid carcinoma in the lung is relatively rare. It rarely presents with the highly malignant biological characteristic of bone marrow metastasis. We describe a case of this disease with bone marrow metastasis. A 56-year-old man with the primary manifestation of bone pain and bloodstained sputum had two abnormal shadows on the left inferior lobar bronchus and peripheral tissue of the lower lobe of the left lung, respectively. Computed tomography-guided percutaneous puncture biopsy and bone imaging confirmed the diagnosis of high-grade bronchial mucoepidermoid carcinoma with bone metastasis. However, the patient soon presented with progressive hemoglobin and platelet decline and severe multi-organ hemorrhage. Subsequently, we performed bone marrow aspiration and biopsy, which revealed malignant cells and necrosis. The patient deteriorated rapidly from the disease, and died on the 16th day of admission. We hope that this case report will increase awareness of the possibility of primary high-grade bronchial mucoepidermoid carcinoma metastasizing to the bone marrow, which might be a poor prognostic factor.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Pan
authors.forename: Guozi
authors.initials: G
authors.lastname: Yang
authors.forename: Limei
authors.initials: L
authors.lastname: Qu
authors.forename: Tingting
authors.initials: T
authors.lastname: Yuan
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Du
authors.affiliation: Department of Radiotherapy, Norman Bethune First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China. drlhdong@163.com.
authors.forename: Lihua
authors.initials: L
authors.lastname: Dong
mesh_terms: D019046:Bone Marrow Neoplasms / Q000556:secondary* / Q000601:surgery; D001859:Bone Neoplasms / Q000556:secondary* / Q000601:surgery; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D014057:Tomography, X-Ray Computed