title: Central hyperthermia treated with baclofen for patient with pontine hemorrhage.
abstract: Central hyperthermia is a very rare disease; however, once it happens, it is associated with a poor prognosis and high mortality for patients with severe brainstem strokes. Following a pontine hemorrhage, a 46-years-old female developed prolonged hyperthermia. Work-ups to the fever gave no significant clues for the origin of fever, and hyperthermia did not respond to any empirical antibiotics or antipyretic agents. The patient's body temperature still fluctuated in a range of 37.5℃ to 39.2℃. Considering the lesion of hemorrhage, we suspected central hyperthermia rather than infectious diseases. We started with baclofen administration at a dose of 30 mg/day. The body temperature changed to a range of 36.6℃ to 38.2℃. We raised the dose of baclofen to 60 mg/day. The patient's body temperature finally dropped to a normal range. Central hyperthermia, caused by failures of thermoregulatory pathways in brainstem, following the pontine hemorrhage rarely occurs. Baclofen can be used to treat suspected central hyperthermia in a patient with pontine hemorrhage.
authors.affiliation: Department of Rehabilitation Medicine, Konkuk University School of Medicine, Chungju, Korea.
authors.forename: Hyun Cheol
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Department of Rehabilitation Medicine, Konkuk University School of Medicine, Chungju, Korea.
authors.forename: Jong Moon
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Rehabilitation Medicine, Konkuk University School of Medicine, Chungju, Korea.
authors.forename: Jae Kuk
authors.initials: JK
authors.lastname: Lim
authors.affiliation: Department of Neurology, Konkuk University School of Medicine, Chungju, Korea.
authors.forename: Yoon Sik
authors.initials: YS
authors.lastname: Jo
authors.affiliation: Department of Rehabilitation Medicine, Konkuk University School of Medicine, Chungju, Korea.
authors.forename: Shin Kyoung
authors.initials: SK
authors.lastname: Kim
keywords: Baclofen; Fever; Hemorrhage; Pons