title: Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-disubstituted benzofurans.
abstract: A highly efficient palladium-catalyzed α-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cyclodehydration of the resulting α-arylated aryloxyketones provided rapid access to diverse 2,3-disubstitured benzofurans.
authors.affiliation: College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University , 85 Songdogwahak-ro, Yeonsu-gu, Incheon 406-840, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Myungock
authors.initials: M
authors.lastname: Kim
authors.forename: Ikyon
authors.initials: I
authors.lastname: Kim
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D001572:Benzofurans; D007659:Ketones; D010165:Palladium