title: Angiogenic Effect of Mesenchymal Stem Cells as a Therapeutic Target for Enhancing Diabetic Wound Healing.
abstract: Impaired wound-healing activity in diabetes could result from several factors, including severely damaged angiogenic responses, which can affect wound healing process to cause delayed wound repair. Mesenchymal stem cells (MSCs) have been shown to enhance wound healing via multiple effects, including promoting angiogenesis both in vitro and in vivo; however, the mechanisms involved in enhancing diabetic wound healing are barely understood. This article reviews the recent literatures on MSCs treatment for promoting angiogenesis or vascularization in diabetic wounds and the potential mechanisms involved, with an emphasis on the role of paracrine soluble factors. Meanwhile, the potential benefits and related risks associated with the therapeutic use of MSCs have been presented and may lead to better understanding of the influence of MSCs without increasing potential risks. Further investigation will be required to determine the molecular basis of paracrine mechanisms and regulated angiogenesis of MSCs for its rational manipulation for impaired angiogenesis repair and diabetic wound healing.
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, PR China The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China.
authors.forename: Chengwei
authors.initials: C
authors.lastname: Gu
authors.affiliation: The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, PR China Hainan Branch of the Chinese PLA General Hospital, Sanya, Hainan Province, PR China.
authors.forename: Sha
authors.initials: S
authors.lastname: Huang
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, PR China The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China.
authors.forename: Dongyun
authors.initials: D
authors.lastname: Gao
authors.affiliation: The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Mudanjiang Medical College, Mudanjiang, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, PR China The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China.
authors.forename: Kui
authors.initials: K
authors.lastname: Ma
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, PR China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
authors.affiliation: The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, PR China fuxiaobing@vip.sina.com 13926402695@126.com stellarahuang@sina.com.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
keywords: angiogenesis; mesenchymal stem cells; paracrine factors; vascularization; wound healing