title: Distinct age-matched serum biomarker profiles in patients with cutaneous T-cell lymphoma.
abstract: Immunological functions decline with age. Because MS/SzS predominately affects the elderly, it is important to distinguish age-related from cancer-specific changes. Also, MF and SzS are malignancies of CD4(+) T-lymphocytes, further compromising an immune state of the patients. The objectives of this study were to distinguish disease-specific immunological deterioration by performing comparative age-matched Luminex multiplex assessment of 34 serum biomarkers between patients with MF/SzS, HIV-infected individuals and normal controls. Controlling for age, expression level appears to significantly differ between patients with MF/SzS and controls for the following biomarkers: G-CSF, IL-5, MIP-1β, TNF-α, VEGF, EOTAXIN, IL-8, IL-12, IL-2R, IP10, MCP-1, MIG, TNFR1 and TNFR2 (P < 0.05), while others showed normal age-related changes. Interestingly, cluster analysis placed MF/SzS profiles closer to HIV. This further underscores an immunologically compromised state of patients with MF/SzS and suggests its potential self-perpetuating role in disease progression.
authors.affiliation: Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Dermatology, Columbia University, New York, NY, USA.
authors.forename: Larisa J
authors.initials: LJ
authors.lastname: Geskin
authors.forename: Oleg E
authors.initials: OE
authors.lastname: Akilov
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Anna E
authors.initials: AE
authors.lastname: Lokshin
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D054407:Chemokine CCL4 / Q000097:blood*; D018450:Disease Progression; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D015658:HIV Infections / Q000097:blood; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D009182:Mycosis Fungoides / Q000097:blood; D012751:Sezary Syndrome / Q000097:blood* / Q000175:diagnosis; D012878:Skin Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D054407:Chemokine CCL4; D015848:Interleukin-5; D016179:Granulocyte Colony-Stimulating Factor
keywords: age; biomarkers; cutaneous T-cell lymphoma; cytokines