title: The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury.
abstract: Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients suffer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. Therefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury. Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.
authors.affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hsu
authors.affiliation: Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
authors.forename: Che-Mai
authors.identifier: 0000-0002-0353-9744
authors.initials: CM
authors.lastname: Chang
authors.affiliation: Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan.
authors.forename: Chung-Che
authors.initials: CC
authors.lastname: Wu
authors.affiliation: Department of Emergency Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
authors.forename: Ju-Chi
authors.initials: JC
authors.lastname: Ou
authors.affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
authors.forename: Yan-Rou
authors.initials: YR
authors.lastname: Tsai
authors.affiliation: Ministry of Health and Welfare, Taipei 10341, Taiwan.
authors.forename: Wen-Ta
authors.initials: WT
authors.lastname: Chiu
authors.affiliation: Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan ; Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan ; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
authors.affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan ; Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei 11031, Taiwan.
authors.forename: Yung-Hsiao
authors.initials: YH
authors.lastname: Chiang
authors.affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei 11031, Taiwan.
authors.forename: Kai-Yun
authors.initials: KY
authors.lastname: Chen
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D015984:Causality; D015897:Comorbidity; D004244:Dizziness / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D063189:Symptom Assessment; D013624:Taiwan / Q000453:epidemiology
chemical_list: D005819:Genetic Markers