title: NMR-based dynamics of free glycosaminoglycans in solution.
abstract: Glycosaminoglycans (GAGs) comprise a special class of complex carbohydrates endowed with numerous biological functions. Most of these functions are regulated by conformational arrangements or dynamical properties of GAGs in solution. Nuclear magnetic resonance (NMR) is a powerful technique used for dynamic analyses. Spin relaxation, scalar couplings, chemical shifts and nuclear Overhauser effect resonances are the commonest NMR parameters utilized in such analyses. Computational molecular dynamics are also very often employed in conjunction with, or restrained by, the NMR dataset. This report aims at describing the major NMR-based information available so far concerning the dynamical properties of free GAGs in solution.
authors.affiliation: Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, 255, HUCFF 4A01, Ilha do Fundão, Rio de Janeiro, RJ 21941-913, Brazil. pominvh@bioqmed.ufrj.br.
authors.forename: Vitor H
authors.initials: VH
authors.lastname: Pomin
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D006025:Glycosaminoglycans / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D056004:Molecular Dynamics Simulation
chemical_list: D006025:Glycosaminoglycans