title: Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study.
abstract: Renal denervation (RDN) is a promising novel treatment for resistant hypertension. Effectiveness of treatment is, however, highly variable and unpredictable. Incomplete denervation of the renal nerves is a plausible explanation for the variable blood pressure lowering effect of RDN. Here, we present for the first time a histopathological evaluation of the effects of RDN on perivascular nerves of the renal arteries in a human patient. Our findings potentially have important implications for future directions with RDN.
authors.affiliation: Department of Nephrology, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Eva E
authors.initials: EE
authors.lastname: Vink
authors.affiliation: Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Roel
authors.initials: R
authors.lastname: Goldschmeding
authors.affiliation: Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Aryan
authors.initials: A
authors.lastname: Vink
authors.affiliation: Department of Pathology, Bethesda Hospital Hoogeveen, Hoogeveen, Netherlands.
authors.forename: Callista
authors.initials: C
authors.lastname: Weggemans
authors.affiliation: Department of Anatomy, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Ronald L A W
authors.initials: RL
authors.lastname: Bleijs
authors.affiliation: Department of Nephrology, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blankestijn
mesh_terms: D000328:Adult; D001794:Blood Pressure; D017115:Catheter Ablation / Q000379:methods*; D003714:Denervation / Q000009:adverse effects* / Q000379:methods; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000294:innervation*; D016896:Treatment Outcome
keywords: hypertension; renal denervation; renal nerves