title: Dopamine release in nucleus accumbens during rewarded task switching measured by [¹¹C]raclopride.
abstract: Reward and motivation have positive influences on cognitive-control processes in numerous settings. Models of reward implicate corticostriatal loops and the dopamine (DA) system, with special emphasis on D2 receptors in nucleus accumbens (NAcc). In this study, 11 right-handed males (35-40 years) were scanned with positron emission tomography (PET) in a single [(11)C]raclopride dynamic scan during rewarded and non-rewarded task switching. Rewarded task switching (relative to baseline task switching) decreased [(11)C]raclopride binding in NAcc. Decreasing NAcc [(11)C]raclopride binding was strongly associated with task reaction time measures that reflect individual differences in effort and control strategies. Voxelwise analyses additionally revealed reward-related DA release in anterodorsal caudate, a region previously associated with task-switching. These PET findings provide evidence for striatal DA release during motivated cognitive control, and further suggest that NAcc DA release predicts the task reaction time benefits of reward incentives.
authors.affiliation: Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, SE-901 87 Umeå, Sweden; Centre for Population Studies, Ageing and Living Conditions, Umeå University, SE-901 87 Umeå, Sweden. Electronic address: lars.jonasson@diagrad.umu.se.
authors.forename: Lars S
authors.initials: LS
authors.lastname: Jonasson
authors.affiliation: Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Axelsson
authors.affiliation: Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Katrine
authors.initials: K
authors.lastname: Riklund
authors.affiliation: Department of Psychology, Washington University, St Louis, MO 63130, USA.
authors.forename: Todd S
authors.initials: TS
authors.lastname: Braver
authors.affiliation: Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Ögren
authors.affiliation: Aging Research Center, Karolinska Institute, SE-113 30 Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Bäckman
authors.affiliation: Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, SE-901 87 Umeå, Sweden; Department of Integrative Medical Biology, Physiology, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Nyberg
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D003463:Cues; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D005260:Female; D006801:Humans; D008297:Male; D009714:Nucleus Accumbens / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011597:Psychomotor Performance / Q000502:physiology; D020891:Raclopride; D011930:Reaction Time / Q000502:physiology; D012201:Reward
chemical_list: D018492:Dopamine Antagonists; D020891:Raclopride; D004298:Dopamine
keywords: Dopamine; Motivation; Nucleus accumbens; PET; Reward; Working memory