title: Lipid peroxidation in psychiatric illness: overview of clinical evidence.
abstract: The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease.
authors.affiliation: Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, MERB 947, 3500 North Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Yash B
authors.initials: YB
authors.lastname: Joshi
authors.affiliation: Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, MERB 947, 3500 North Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Domenico
authors.initials: D
authors.lastname: Praticò
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000378:metabolism; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology