title: Iron overload is associated with perihematoma edema growth following intracerebral hemorrhage that may contribute to in-hospital mortality and long-term functional outcome.
abstract: Iron overload may contribute to brain damage that involves delayed brain atrophy, edema, and neuronal cell death as well as unfavorable outcome following ischemic stroke and intracerebral hemorrhage (ICH). This prospective study was performed to determine the association of serum ferritin level, an iron storage protein, with perihematoma edema (PHE) growth as well as in-hospital mortality and long-term clinical outcome of patients with ICH. Data was collected from patients with ICH from February 2011 to April 2012. Demographic and clinical data were recorded and serum ferritin was measured on admission. Brain CT scan was performed on admission and 72 hours later. Volume of hematoma and PHE was calculated using ABC/2 formula. Functional outcome was assessed using modified Rankin Scale. A total of 63 patients were included in this study, of those 11 (17.5%) patients died during the first 72 hours of admission. There was a significant correlation between PHE growth during first 72 hours of hospitalization and serum ferritin (P<0.001) as well as history of diabetes mellitus (P<0.001). PHE growth during the first 72-hours of hospitalization and baseline hematoma volume were both predictors of in-hospital mortality and poor outcome (P=0.026 and P=0.035, respectively). These results indicate the role of iron overload in the development of PHE following ICH. However, it seems that serum ferritin level is not directly associated with in-hospital mortality and long-term functional outcome.
authors.forename: Babak
authors.initials: B
authors.lastname: Bakhshayesh
authors.forename: Mozaffar
authors.initials: M
authors.lastname: Hosseininezhad
authors.forename: Seyedeh Nazanin Seyed
authors.initials: SN
authors.lastname: Saadat
authors.forename: Malek Moien
authors.initials: MM
authors.lastname: Ansar
authors.forename: Hamed
authors.initials: H
authors.lastname: Ramezani
authors.affiliation: Department of Neurology, Guilan University of Medical Sciences, Poursina Hospital, Rasht, Iran, Postal Code: 41686-48676. arman.saadat@gmail.com.
authors.forename: Seyed Mohammad Seyed
authors.initials: SM
authors.lastname: Saadat
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001929:Brain Edema / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000401:mortality*; D005260:Female; D006406:Hematoma / Q000209:etiology*; D017052:Hospital Mortality; D006801:Humans; D019190:Iron Overload / Q000150:complications / Q000209:etiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed