title: Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis in East Asians: a systematic review and meta-analysis.
abstract: BACKGROUND
  The rs11190870 single nucleotide polymorphism in the 3'-flanking region of the LBX1 gene has been implicated in the etiology of adolescent idiopathic scoliosis (AIS). A thorough appraisal of the evidence supporting this association has not been previously attempted.
  
  
  OBJECTIVE
  To provide a comprehensive assessment and synthesis of the currently available evidence on the association between rs11190870 and AIS.
  
  
  METHODS
  A systematic review and meta-analysis.
  
  
  METHODS
  This review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. PubMed (MEDLINE), EMBASE, Scopus, and HuGE Literature Finder databases were systematically searched through November 2013 to identify relevant studies following a sensitive strategy. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using the fixed-effect inverse variance model for allelic (T vs. C) and genotypic comparisons.
  
  
  RESULTS
  Meta-analysis of four studies conducted in East Asian populations (n=3,215 AIS cases and n=15,347 controls) found a highly statistically significant and robust association between rs11190870 and AIS. Comparison of summary ORs indicated a codominant model effect of the T allele. Carriers of the TC and TT genotypes were 69% (OR=1.69, 95% CI: 1.48-1.94, p<.001) and 162% (OR=2.62, 95% CI: 2.28-3.02, p<.001), respectively, more likely to have AIS compared with carriers of the CC genotype.
  
  
  CONCLUSIONS
  Based on a comprehensive analysis of the currently available evidence, rs11190870 is likely a susceptibility variant for AIS in East Asians. Further investigation of this association is necessary in other populations.
authors.affiliation: University of Ottawa Spine Program, The Ottawa Hospital, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9. Electronic address: suzan.chen@gmail.com.
authors.forename: Suzan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St., New Haven, CT, USA, 06510.
authors.forename: Linlu
authors.initials: L
authors.lastname: Zhao
authors.affiliation: University of Ottawa Spine Program, The Ottawa Hospital, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9; Clinical Epidemiology Program, Ottawa Hospital Research Institute, 725 Parkdale Ave., Ottawa, Ontario, Canada, K1Y 4E9.
authors.forename: Darren M
authors.initials: DM
authors.lastname: Roffey
authors.affiliation: University of Ottawa Spine Program, The Ottawa Hospital, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9; Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9.
authors.forename: Philippe
authors.initials: P
authors.lastname: Phan
authors.affiliation: University of Ottawa Spine Program, The Ottawa Hospital, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9; Clinical Epidemiology Program, Ottawa Hospital Research Institute, 725 Parkdale Ave., Ottawa, Ontario, Canada, K1Y 4E9; Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, 1053 Carling Ave., Ottawa, Ontario, Canada, K1Y 4E9.
authors.forename: Eugene K
authors.initials: EK
authors.lastname: Wai
mesh_terms: D000293:Adolescent; D044466:Asian People; D016022:Case-Control Studies; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012600:Scoliosis / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; C542809:LBX1 protein, human; D014157:Transcription Factors
keywords: Adolescent idiopathic scoliosis; Etiology; Genetic association study; LBX1; Ladybird homeobox 1; Single nucleotide polymorphism; rs11190870