title: Size- and dose-dependent toxicity of cellulose nanocrystals (CNC) on human fibroblasts and colon adenocarcinoma.
abstract: A controlled preparation of cellulose nanocrystals of different sizes and shapes has been carried out by acid hydrolysis of microcrystalline cellulose. The size- and concentration-dependent toxicity effects of the resulting cellulose nanocrystals were evaluated against two different cell lines, NIH3T3 murine embryo fibroblasts and HCT116 colon adenocarcinoma. It could serve as a therapeutic platform for cancer treatment.
authors.affiliation: Department of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, South Korea.
authors.forename: Zahid
authors.initials: Z
authors.lastname: Hanif
authors.affiliation: Department of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, South Korea; Department of Pharmaceutics, Ziauddin University, Karachi 75600, Pakistan.
authors.forename: Farrukh R
authors.initials: FR
authors.lastname: Ahmed
authors.affiliation: School of Chemical Engineering Sungkyunkwan University, Suwon 440-746, South Korea.
authors.forename: Seung Won
authors.initials: SW
authors.lastname: Shin
authors.affiliation: Department of Chemical Engineering, Hankyong National University, Anseong 456-749, South Korea.
authors.forename: Young-Kee
authors.initials: YK
authors.lastname: Kim
authors.affiliation: School of Chemical Engineering Sungkyunkwan University, Suwon 440-746, South Korea; SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, South Korea. Electronic address: sh.um@skku.edu.
authors.forename: Soong Ho
authors.initials: SH
authors.lastname: Um
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects* / Q000473:pathology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D006868:Hydrolysis; D051379:Mice; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity* / Q000648:ultrastructure
chemical_list: D002482:Cellulose; C109691:microcrystalline cellulose
keywords: Cancer cell; Cellulose nanocrystal; Toxicity