title: [The brain histamine H3 receptors: sleep-wake control and novel therapeutic targets for sleep disorders].
abstract: Histaminergic neurons are located exclusively in the posterior hypothalamus from where they project to virtually all brain areas and fulfill a major role in the maintenance of waking. H3-receptors are firstly autoreceptors damping the release and synthesis of histamine and the firing of histamine neurons. This action also extends to heteroreceptors on most other neurotransmitter systems, allowing a powerful control over multiple homeostatic functions. The particular properties and locations of H3-receptors provide quite favorable attributes to make this a most promising target for sleep-wake control and sleep disorders. This review summarizes the most recent data on the role of H3-receptor in physiological sleep-wake regulation and preclinical and clinical evidence supporting H3-receptor as brain target for therapy of sleep and vigilance disorders.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Lin
mesh_terms: D001921:Brain; D006706:Homeostasis; D006801:Humans; D018100:Receptors, Histamine H3; D012890:Sleep; D012893:Sleep Wake Disorders; D014851:Wakefulness
chemical_list: D018100:Receptors, Histamine H3