title: The CCND1 G870A gene polymorphism and brain tumor risk: a meta-analysis.
abstract: BACKGROUND
  In recent years, numerous studies have been performed to investigate the CCND1 G870A gene polymorphism impact on brain tumors susceptibility. Unfortunately, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of any association.
  
  
  METHODS
  We conducted a search in PubMed, Embase and CNKI covering all published papers up to November, 2013. Odds ratios (ORs) and their 95% confidence intervals (95%CIs) were applied to assess associations.
  
  
  RESULTS
  A total of 6 publications including 9 case-control studies met the inclusion criteria. The pooled ORs for the total included studies showed significant association among comparison A vs G (OR= 1.246, 95%CI= 1.092-1.423, p= 0.001), homozygote comparison AA vs GG (OR= 1.566, 95%CI= 1.194-2.054, p= 0.001), heterozygote comparison AG vs GG (OR= 1.290, 95%CI= 0.934-1.782, p= 0.122), dominant model AA/GA vs GG (OR= 1.381, 95%CI= 1.048-1.821, p= 0.022) and recessive model AA vs GA/GG (OR= 1.323, 95%CI= 1.057- 1.657, p= 0.015) especially in glioma.
  
  
  CONCLUSIONS
  CCND1 G870A polymorphism may increase brain tumor risk, especially for gliomas. However, more primary large scale and well-designed studies are still required to evaluate the interaction of CCND1 G870A polymorphism with brain tumor risk.
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, China E-mail : mown16300@126.com.
authors.forename: Ling-Yan
authors.initials: LY
authors.lastname: Qin
authors.forename: Li-Gang
authors.initials: LG
authors.lastname: Zhao
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Wu-Ning
authors.initials: WN
authors.lastname: Mo
mesh_terms: D000236:Adenoma / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008579:Meningioma / Q000235:genetics*; D009464:Neuroma, Acoustic / Q000235:genetics*; D016017:Odds Ratio; D010911:Pituitary Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1