title: Visible-light-induced direct C(sp3)-H difluromethylation of tetrahydroisoquinolines with the in situ generated difluoroenolates.
abstract: An effective approach to C1-difluoromethylated tetrahydroisoquinoline derivatives has been developed through C-H functionalization of tertiary amines by visible-light photoredox catalysis. This method uses stable, easily obtained α,α-difluorinated gem-diol as the CF2 source. The corresponding products were obtained in moderate to high yields at ambient temperature.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. cjzhu@nju.edu.cn.
authors.forename: Weipeng
authors.initials: W
authors.lastname: Li
authors.forename: Xuebin
authors.initials: X
authors.lastname: Zhu
authors.forename: Haibin
authors.initials: H
authors.lastname: Mao
authors.forename: Zhongkai
authors.initials: Z
authors.lastname: Tang
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D008027:Light; D008745:Methylation; D055668:Photochemical Processes; D044005:Tetrahydroisoquinolines / Q000737:chemistry* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D044005:Tetrahydroisoquinolines