title: c-Fos: an AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity.
abstract: The mechanisms that co-ordinately activate lipid synthesis when high rates of membrane biogenesis are needed to support cell growth are largely unknown. c-Fos, a well known AP-1 transcription factor, has emerged as a unique protein with the capacity to associate to specific enzymes of the pathway of synthesis of phospholipids at the endoplasmic reticulum and activate their synthesis to accompany genomic decisions of growth. Herein, we discuss this cytoplasmic, non-genomic effect of c-Fos in the context of other mechanisms that have been proposed to regulate lipid synthesis.
authors.affiliation: CIQUIBIC (CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: bcaputto@fcq.unc.edu.
authors.forename: Beatriz L
authors.initials: BL
authors.lastname: Caputto
authors.affiliation: CIQUIBIC (CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Andrés M
authors.initials: AM
authors.lastname: Cardozo Gizzi
authors.affiliation: CIQUIBIC (CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Germán A
authors.initials: GA
authors.lastname: Gil
mesh_terms: D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D050356:Lipid Metabolism; D015778:Minor Histocompatibility Antigens; D010743:Phospholipids / Q000096:biosynthesis* / Q000235:genetics; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015778:Minor Histocompatibility Antigens; D010743:Phospholipids; D016760:Proto-Oncogene Proteins c-fos; D017853:Phosphotransferases (Alcohol Group Acceptor); C402182:phosphatidylinositol phosphate 4-kinase
keywords: Membrane biogenesis regulation; PI4KIIα/c-Fos association; Phospholipid synthesizing enzymes regulation; c-Fos/CDS association