title: Avian-like A (H1N1) swine influenza virus antibodies among swine farm residents and pigs in southern China.
abstract: Infection of human with avian-like A (H1N1) swine influenza virus (SIV) occasionally occurs in China, suggesting a potential risk of cross-species transmission of the swine influenza H1N1 virus from pigs to humans, particularly to those having direct contact with pigs. A seroepidemiological study was conducted to assess the prevalence of antibodies against the avian-like A (H1N1) SIV among swine farm residents and pigs in southern China to evaluate the risk of infection to swine farm workers. Hemagglutination inhibition (HI) assays revealed that 11.17% (61/546) of the sera samples from swine farm residents in southern China were positive for antibodies against the avian-like A (H1N1) SIV. The difference in numbers of antibody-positive samples obtained from swine farm residents and a control group of healthy city residents was statistically significant (P = 0.031). In addition, 219 of the 1,180 serum samples from pigs were positive for the antibodies against an avian-like A (H1N1) SIV, A/swine/Guangdong/SS1/2013(H1N1), as assessed by HI. The data suggest that occupational exposure of swine farm residents and veterinarians in southern China to pigs may increase their risk of acquiring avian-like A (H1N1) SIV infection. According to a special pig farming model in southern China, the staff and residents are in close contact with infected pigs and may be among the first to become infected.
authors.affiliation: Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture, South China Agricultural University.
authors.forename: Han
authors.initials: H
authors.lastname: Zhou
authors.forename: Zhenpeng
authors.initials: Z
authors.lastname: Cao
authors.forename: Likai
authors.initials: L
authors.lastname: Tan
authors.forename: Xinliang
authors.initials: X
authors.lastname: Fu
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.forename: Wenbao
authors.initials: W
authors.lastname: Qi
authors.forename: Changwen
authors.initials: C
authors.lastname: Ke
authors.forename: Heng
authors.initials: H
authors.lastname: Wang
authors.forename: Lingshuang
authors.initials: L
authors.lastname: Sun
authors.forename: Guihong
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000382:Agricultural Workers' Diseases / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary* / Q000821:virology*; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015047:Zoonoses / Q000453:epidemiology / Q000276:immunology / Q000821:virology
chemical_list: D000914:Antibodies, Viral