title: Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata.
abstract: In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-galloylbergenin for the first time. Both compounds were isolated from Bergenia ligulata. 11-O-galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-galloylbergenin were 7.45±0.2 μg/mL and 5.39±0.28 μg/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay of both compounds were less than 2.5 μM. Interestingly, in the total antioxidant phosphomolybdate assay, 11-O-galloylbergenin was found more potent (CAHT: 940.04±115.30) as compared to α-tocopherol (CAHT: 552.4±27.91).
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, Pakistan.
authors.forename: G
authors.initials: G
authors.lastname: Uddin
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Sadat
authors.affiliation: HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: B S
authors.initials: BS
authors.lastname: Siddiqui
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: C556377:11-O-galloylbergenin; D000962:Antimalarials; D000975:Antioxidants; D001578:Benzopyrans; D010936:Plant Extracts; D005707:Gallic Acid; C006741:bergenin