title: Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with acute myocardial infarction.
abstract: BACKGROUND
  Acute myocardial infarction (AMI) is one of the leading causes for death in both developed and developing countries and it is the single largest cause of death in the United States, responsible for 1 out of every 6 deaths. The objective of this study was to determine microRNA (miRNA) expression in AMI and determine whether miR-133, miR-1291 and miR-663b could be measured in plasma as a biomarker for recurrence.
  
  
  METHODS
  Patients with AMI and those without AMI were retrospectively recruited for a comparison of their plasma miR-133, miR-1291 and miR-663b expression.
  
  
  RESULTS
  miR-133, miR-1291 and miR-663b levels were significantly overexpressed in AMI compared with Non-AMI. MiR-133 showed an AUC of 0.912, with a sensitivity of 81.1% and a specificity of 91.2%. The AUC for miR-1291 was 0.695, with a sensitivity of 78.4% and a specificity of 89.5%. The AUC for miR-663b was 0.611, with a sensitivity of 72.4% and a specificity of 76.5%.
  
  
  CONCLUSIONS
  This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8183629061241474.
authors.forename: Liu
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Cardiology, the First affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. mdqcg09@163.com.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Chun-guang
authors.forename: Li
authors.initials: L
authors.lastname: Bei-fang
authors.forename: Ding
authors.initials: D
authors.lastname: Xue-zhi
authors.forename: Wang
authors.initials: W
authors.lastname: Zi-hao
authors.forename: Li
authors.initials: L
authors.lastname: Yun-fu
authors.forename: Dang
authors.initials: D
authors.lastname: Yan-ping
authors.forename: Liu
authors.initials: L
authors.lastname: Yang-gui
authors.forename: Li
authors.initials: L
authors.lastname: Wei-guo
authors.forename: Hu
authors.initials: H
authors.lastname: Tian-yong
authors.forename: Huang
authors.initials: H
authors.lastname: Zhen-wen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D005260:Female; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D005819:Genetic Markers; C587958:MIRN1291 microRNA, human; C548234:MIRN133 microRNA, human; C552243:MIRN663 microRNA, human; D035683:MicroRNAs