title: Abnormal baseline brain activity in patients with pulsatile tinnitus: a resting-state FMRI study.
abstract: Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n = 42) and age-, sex-, and education-matched normal control subjects (n = 42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Lv
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Zhaohui
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Fei
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ting
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Pengfei
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Du
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Pengde
authors.affiliation: Department of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Han
authors.initials: H
authors.lastname: Xiaoyi
authors.affiliation: Department of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Li
authors.initials: L
authors.lastname: Rui
authors.affiliation: Department of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhenchang
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D009473:Neuronal Plasticity / Q000502:physiology; D012146:Rest / Q000502:physiology; D014012:Tinnitus / Q000503:physiopathology*; D055815:Young Adult