title: Rotational spectrum of tryptophan.
abstract: The rotational spectrum of the natural amino acid tryptophan has been observed for the first time using a combination of laser ablation, molecular beams, and Fourier transform microwave spectroscopy. Independent analysis of the rotational spectra of individual conformers has conducted to a definitive identification of two different conformers of tryptophan, with one of the observed conformers never reported before. The analysis of the (14)N nuclear quadrupole coupling constants is of particular significance since it allows discrimination between structures, thus providing structural information on the orientation of the amino group. Both observed conformers are stabilized by an O-H···N hydrogen bond in the side chain and a N-H···π interaction forming a chain that reinforce the strength of hydrogen bonds through cooperative effects.
authors.affiliation: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico Uva, Universidad de Valladolid, 47011 Valladolid, Spain.
authors.forename: M Eugenia
authors.initials: ME
authors.lastname: Sanz
authors.affiliation: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico Uva, Universidad de Valladolid, 47011 Valladolid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cabezas
authors.affiliation: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico Uva, Universidad de Valladolid, 47011 Valladolid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Mata
authors.affiliation: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico Uva, Universidad de Valladolid, 47011 Valladolid, Spain.
authors.forename: Josè L
authors.initials: JL
authors.lastname: Alonso
mesh_terms: D005583:Fourier Analysis; D005740:Gases / Q000737:chemistry; D006860:Hydrogen Bonding; D007834:Lasers; D008872:Microwaves; D008958:Models, Molecular; D008968:Molecular Conformation; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D005740:Gases; D014364:Tryptophan