title: Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction.
abstract: A convenient one-pot reaction was conducted by mixing bromoacetophenone, a functionalized α,β-unsaturated ketone and potassium hydroxide in tetrahydrofuran at room temperature, ammonium acetate was added and heated to reflux, resulting in four chemical bonds forming from easily accessible substrates. This process provides a flexible and rapid synthetic route for the construction of polysubstituted benzofuro[2,3-c]pyridines in moderate to good yields.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Wuhan University of Technology, Wuhan, 430070, China. hyvzfl@gmail.com zhenghua.whut@126.com.
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Hu
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Deng
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Zhang
authors.forename: Fanglin
authors.initials: F
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Zheng
mesh_terms: D011725:Pyridines / Q000138:chemical synthesis*
chemical_list: D011725:Pyridines