title: [Maternal and perinatal infections to Streptococcus agalactiae].
abstract: Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive encapsulated bacterium, found in the digestive and vaginal tracts of 20-30% healthy individuals. It is the leading cause of neonatal invasive infections (septicaemia and meningitis). Two GBS-associated syndromes have been recognized in neonates, the early-onset disease (EOD) and the late-onset disease (LOD), which occur in the first week of life (age 0-6 days) and after (age 7 days-3 months), respectively. Since the establishment of early antibiotic prophylaxis there has been a decrease in the incidence of EOD. However, LOD incidence remains stable. Epidemiological studies revealed a strong association between LOD and a single capsular serotype III ST-17 clone. This ST-17 clone, referred to as the "hypervirulent" clone, possesses specific virulence factors that could account for its increased virulence and neonatal tropism. Conjugate vaccines directed against several capsular serotypes are being developed to prevent invasive disease. However, hypervirulent strains having made a switch to a capsular serotype not covered by such vaccines are emerging, reinforcing the need to identify new candidate vaccines.
authors.affiliation: Inserm U 1016, institut Cochin, unité FRM « Barrières et pathogènes », 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Six
authors.affiliation: Centre national de référence des streptocoques, 75014 Paris, France; Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Centre Site Cochin, service de bactériologie, 75014 Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Joubrel
authors.affiliation: Inserm U 1016, institut Cochin, unité FRM « Barrières et pathogènes », 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France; Centre national de référence des streptocoques, 75014 Paris, France; Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Centre Site Cochin, service de bactériologie, 75014 Paris, France.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Tazi
authors.affiliation: Inserm U 1016, institut Cochin, unité FRM « Barrières et pathogènes », 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France; Institut Pasteur, unité de biologie des bactéries pathogènes à Gram positif, 74016 Paris, France; CNRS 2172, 75015 Paris, France; Centre national de référence des streptocoques, 75014 Paris, France; Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Centre Site Cochin, service de bactériologie, 75014 Paris, France. Electronic address: claire.poyart@cch.aphp.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Poyart
mesh_terms: D019072:Antibiotic Prophylaxis; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000517:prevention & control / Q000635:transmission; D011247:Pregnancy; D018805:Sepsis / Q000175:diagnosis / Q000517:prevention & control / Q000635:transmission; D013290:Streptococcal Infections / Q000175:diagnosis / Q000517:prevention & control / Q000635:transmission*; D022541:Streptococcal Vaccines / Q000627:therapeutic use; D013292:Streptococcus agalactiae; D018074:Vaccines, Conjugate / Q000627:therapeutic use; D014621:Vagina / Q000382:microbiology
chemical_list: D022541:Streptococcal Vaccines; D018074:Vaccines, Conjugate