title: Bioactive oligosaccharide natural products.
abstract: Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments of such diverse diseases as bacterial infections and type II diabetes. Despite their potent and selective activities and potential clinical relevance, isolated bioactive secondary metabolic oligosaccharides are less prevalent than other classes of natural products and their biosynthesis has received comparatively less attention. This review highlights the unique modes of action and biosynthesis of four classes of bioactive oligosaccharides: the orthosomycins, moenomycins, saccharomicins, and acarviostatins.
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, USA. brian.bachmann@vanderbilt.edu.
authors.forename: Emilianne K
authors.initials: EK
authors.lastname: McCranie
authors.forename: Brian O
authors.initials: BO
authors.lastname: Bachmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009844:Oligosaccharides / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D009844:Oligosaccharides; D000516:alpha-Amylases