title: Intracellular drug concentration and disposition--the missing link?
abstract: Improved understanding of the concentration of a potential drug molecule at the site of action in physiologically relevant cells or tissues has emerged as a key challenge in the early stages of drug discovery. Improved ability to carry out such studies with label-free methodology has the potential to improve understanding of drug uptake and trafficking and thus contribute to the reduction of rates of attrition in drug discovery.
authors.affiliation: Platform Technology and Science, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. Electronic address: mike.m.hann@gsk.com.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Hann
authors.affiliation: Platform Technology and Science, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Simpson
mesh_terms: D003593:Cytoplasm / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D010539:Permeability / Q000187:drug effects