title: Evaluation of the QuEChERS method for the extraction of pharmaceuticals and personal care products from drinking-water treatment sludge with determination by UPLC-ESI-MS/MS.
abstract: A modified version of the QuEChERS method has been evaluated for the determination of 21 pharmaceuticals and 6 personal care products (PPCPs) in drinking-water sludge samples by employing ultra high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The performance of the method was evaluated through linearity, recovery, precision (intra-day), method detection and quantification limits (MDL and MQL) and matrix effect. The calibration curves prepared in acetonitrile and in the matrix extract showed a correlation coefficient ranging from 0.98 to 0.99. MQLs values were on the ng g(-1) order of magnitude for most compounds. Recoveries between 50% and 93% were reached with RSDs lower than 10% for most compounds. Matrix effect was almost absent with values lower than 16% for 93% of the compounds. By coupling a quick and simple extraction called QuEChERS with the UPLC-MS/MS analysis, a method that is both selective and sensitive was obtained. This methodology was successfully applied to real samples and caffeine and benzophenone-3 were detected in ng g(-1) levels.
authors.affiliation: Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil.
authors.forename: Maristela B R
authors.initials: MBR
authors.lastname: Cerqueira
authors.affiliation: Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil.
authors.forename: Juliana R
authors.initials: JR
authors.lastname: Guilherme
authors.affiliation: Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil.
authors.forename: Sergiane S
authors.initials: SS
authors.lastname: Caldas
authors.affiliation: Laboratório de Análises de Resíduos de Pesticidas (LARP), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul State, Brazil.
authors.forename: Manoel L
authors.initials: ML
authors.lastname: Martins
authors.affiliation: Laboratório de Análises de Resíduos de Pesticidas (LARP), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul State, Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Zanella
authors.affiliation: Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil. Electronic address: dqmednei@furg.br.
authors.forename: Ednei G
authors.initials: EG
authors.lastname: Primel
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000032:analysis / Q000302:isolation & purification*; D060766:Drinking Water / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000302:isolation & purification*; D012449:Safety; D012722:Sewage / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000302:isolation & purification; D018508:Water Purification / Q000191:economics / Q000379:methods*
chemical_list: D003358:Cosmetics; D060766:Drinking Water; D004364:Pharmaceutical Preparations; D012722:Sewage; D014874:Water Pollutants, Chemical
keywords: Drinking-water sludge samples; PPCPs; QuEChERS; UPLC-MS/MS