title: Effects of REM sleep deprivation on sensorimotor gating and startle habituation in rats: role of social isolation in early development.
abstract: The present study examined the role of rapid eye movement (REM) sleep on sensorimotor gating function in a developmentally rodent model of schizophrenic-spectrum disorders. Startle magnitude, prepulse inhibition (PPI) and startle habituation in an acoustic startle test were measured after 72-h of REM sleep deprivation (REMSD) in 14-week-old rats that were reared in one of the following conditions: control social interaction, 2-week isolation, and continuous isolation, since weaning. The results showed that REMSD significantly inhibited rats' PPI in socially controlled rats, and rats in two isolation groups appeared less sensitive to REMSD. After REMSD, startle habituation was significantly reduced in continuous-isolated rats but not in 2-week-isolated rats. These data indicate that REM sleep is essential for PPI; REMSD inhibits startle habituation in rats with continuous social isolation. In addition, social interaction, in early life or for the whole life, functions differently to the sensorimotor gating.
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Hsin-An
authors.initials: HA
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan. Electronic address: yiaping@ndmctsgh.edu.tw.
authors.forename: Yia-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: Division of Medical Research & Education, Cheng Hsin General Hospital, Taipei, Taiwan.
authors.forename: Che-Se
authors.initials: CS
authors.lastname: Tung
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chuan-Chia
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Nian-Sheng
authors.initials: NS
authors.lastname: Tzeng
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Huang
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D006185:Habituation, Psychophysiologic; D008297:Male; D065808:Prepulse Inhibition; D017207:Rats, Sprague-Dawley; D013216:Reflex, Startle; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology; D055139:Sensory Gating; D012892:Sleep Deprivation / Q000503:physiopathology / Q000523:psychology*; D012895:Sleep, REM; D012934:Social Isolation
keywords: Isolation rearing; Prepulse inhibition; REM sleep deprivation; Schizophrenia; Startle habituation