title: Motif enrichment tool.
abstract: The Motif Enrichment Tool (MET) provides an online interface that enables users to find major transcriptional regulators of their gene sets of interest. MET searches the appropriate regulatory region around each gene and identifies which transcription factor DNA-binding specificities (motifs) are statistically overrepresented. Motif enrichment analysis is currently available for many metazoan species including human, mouse, fruit fly, planaria and flowering plants. MET also leverages high-throughput experimental data such as ChIP-seq and DNase-seq from ENCODE and ModENCODE to identify the regulatory targets of a transcription factor with greater precision. The results from MET are produced in real time and are linked to a genome browser for easy follow-up analysis. Use of the web tool is free and open to all, and there is no login requirement. ADDRESS: http://veda.cs.uiuc.edu/MET/.
authors.affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA blatti@illinois.edu.
authors.forename: Charles
authors.initials: C
authors.lastname: Blatti
authors.affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D006801:Humans; D020407:Internet; D051379:Mice; D059372:Nucleotide Motifs; D050436:Regulatory Elements, Transcriptional; D017422:Sequence Analysis, DNA; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D004247:DNA