title: Biochemical markers in early diagnosis and management of systemic amyloidoses.
abstract: Systemic amyloid diseases are characterized by widespread protein deposition as amyloid fibrils. Precise diagnostic framing is the prerequisite for a correct management of patients. This complex process is achieved through a series of steps, which include detection of the tissue amyloid deposits, identification of the amyloid type, demonstration of the amyloidogenic precursor, and evaluation of organ dysfunction/damage. Laboratory medicine plays a central role in the diagnosis and management of systemic amyloidoses, through the quantification of the amyloidogenic precursor and evaluation of end-organ damage using biomarkers.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lavatelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Albertini
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Fonzo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palladini
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Merlini
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology / Q000517:prevention & control; D001054:Apolipoproteins A / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D042241:Early Diagnosis; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011228:Prealbumin / Q000378:metabolism; D040901:Proteomics; D014336:Troponin / Q000097:blood
chemical_list: D001054:Apolipoproteins A; D015415:Biomarkers; D007147:Immunoglobulin Light Chains; D010446:Peptide Fragments; D011228:Prealbumin; D014336:Troponin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain