title: Is antibiotic prophylaxis mandatory after the insertion of levonorgestrel-releasing intrauterine systemin order to decrease the risk of pelvic inflammatory disease?
abstract: OBJECTIVE
  This study was undertaken in order to determine if antibiotic prophylaxis is mandatory, after the insertion of levonorgestrel-releasing intrauterine system in order to decrease the risk of pelvic inflammatory disease.
  
  
  METHODS
  We prospectively evaluated 44 patients, admitted in the Bucharest Emergency Hospital between the 1ⁱ of February 2012 and the 1ⁱ of October 2012, in whom the levonorgestrel-releasing intrauterine system was inserted. The patients enrolled were divided into two groups. In group A, a number of 22 patients, received, after the insertion of levonorgestrel-releasing intrauterine system, 875mg Amoxicillin Trihydrate + 125 mg Potassium Clavulanate, a dose every 12 hours for 5 days. Group B was represented by the other 22 patients who did not receive antibiotic prophylaxis. All patients were reevaluated at 4 and 12 weeks after the insertion of levonorgestrel-releasing intrauterine system.
  
  
  RESULTS
  During the first 4 weeks after the insertion of levonorgestrel-releasing intrauterine system only two patients, one from group A and one from group B were diagnosed with pelvic inflammatory disease. At a second follow up visit - 12 weeks after the insertion of levonorgestrel-releasing intrauterine system, no other patient was diagnosed with pelvic inflammatory disease.
  
  
  CONCLUSIONS
  Antibiotic prophylaxis is not mandatory, after the insertion of levonorgestrel-releasing intrauterine system in order to decrease the risk of pelvic inflammatory disease.
authors.affiliation: Department of Obstetrics and Gynecology, Bucharest University Emergency Hospital.
authors.forename: O
authors.initials: O
authors.lastname: Munteanu
authors.affiliation: Department of Biochemistry, "Carol Davila" University of Medicine and Pharmacy, Bucharest.
authors.forename: L
authors.initials: L
authors.lastname: Radulescu
authors.affiliation: Department of Obstetrics and Gynecology, Bucharest University Emergency Hospital.
authors.forename: O
authors.initials: O
authors.lastname: Bodean
authors.affiliation: Department of Orthopedics and Traumatology, Bucharest University Emergency Hospital.
authors.forename: C
authors.initials: C
authors.lastname: Cirstoiu
authors.affiliation: Department of Obstetrics and Gynecology, Bucharest University Emergency Hospital.
authors.forename: D
authors.initials: D
authors.lastname: Secara
authors.affiliation: Department of Obstetrics and Gynecology, Bucharest University Emergency Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Cirstoiu
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis / Q000379:methods*; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D016912:Levonorgestrel / Q000008:administration & dosage*; D000292:Pelvic Inflammatory Disease / Q000517:prevention & control*; D011446:Prospective Studies
chemical_list: D016912:Levonorgestrel
keywords: antibiotic prophylaxis; intrauterine system; levonorgestrel-releasing; pelvic inflammatory disease