title: The cytotoxic, neurotoxic, apoptotic and antiproliferative activities of extracts of some marine algae on the MCF-7 cell line.
abstract: Abstract We investigated the cytotoxic, neurotoxic, apoptotic and antiproliferative effects of extracts from Petalonia fascia, Jania longifurca and Halimeda tuna on the MCF-7 breast cancer cell line. J. longifurca extracts were more toxic than those of P. fascia and H. tuna. The algal extracts showed significant toxic effects at different dilutions. The toxic effects were due to increased oxidative stress and resulted in apoptosis. Algal toxicity may exert negative effects through the food chain or by direct interaction. Algal toxicity also has potential for cancer therapy. The toxic effects that we observed may be especially important for therapy for breast tumors.
authors.affiliation: Celal Bayar University, Faculty of Sciences and Literature, Department of Biology , 45140, Manisa , Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Kurt
authors.forename: F
authors.initials: F
authors.lastname: Ozdal-Kurt
authors.forename: M I
authors.initials: MI
authors.lastname: Tuğlu
authors.forename: C M
authors.initials: CM
authors.lastname: Akçora
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D000460:Chlorophyta / Q000737:chemistry*; D005260:Female; D006801:Humans; D007928:Lethal Dose 50; D061986:MCF-7 Cells; D009498:Neurotoxins / Q000494:pharmacology; D000459:Phaeophyceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D000461:Rhodophyta / Q000737:chemistry*; D012623:Seawater / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D009498:Neurotoxins; D010936:Plant Extracts
keywords: Halimeda tuna; Jania longifurca; MCF-7 cell line; Petalonia fascia; antiproliferative activity; apoptosis; cytotoxicity; neurotoxicity