title: Successful kidney transplant in a patient with IgG anti HLA Class-I auto-antibodies: a case report.
abstract: Donor specific antibodies (DSA) play a significant role in graft rejection. Many laboratory methods, varied in sensitivity and specificity, are used to detect them. We report a case of a 38-year-old man presented with end stage renal disease considered for kidney transplantation. He had no history of blood transfusions nor transplantation procedures. Dilemma rose when he got multiple positive crossmatches with matching donors and a positive autologous crossmatch due to IgG anti HLA auto-antibodies, which are at the same time against matched donors. Since positive crossmatch is a contraindication for transplant, we couldn't perform transplant from any matched donor. Therefore, we considered a total mismatched donor then transplantation was performed. Observation after surgery showed normalization of creatinine, blood pressure and a good function of the planted allograft for two years of follow up.
authors.affiliation: Damascus University, College of Medicine, Syrian Arab Republic. Electronic address: dr.najihamid@gmail.com.
authors.forename: Naji
authors.initials: N
authors.lastname: Alhamid
authors.affiliation: Damascus University, College of Medicine, Syrian Arab Republic.
authors.forename: Hani
authors.initials: H
authors.lastname: Alterky
authors.affiliation: Damascus University, College of Medicine, Syrian Arab Republic.
authors.forename: Amanda
authors.initials: A
authors.lastname: Almouslem
authors.affiliation: Damascus University, College of Medicine, Syrian Arab Republic.
authors.forename: Heba
authors.initials: H
authors.lastname: Al-Rayess
authors.affiliation: Head of Nephrology Department and Kidney Transplant Unit AUH, Damascus University, College of Medicine, Syrian Arab Republic.
authors.forename: Mohammad Imad
authors.initials: MI
authors.lastname: Othman
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015870:Gene Expression; D006085:Graft Survival; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous; D061349:Unrelated Donors
chemical_list: D001323:Autoantibodies; D015395:Histocompatibility Antigens Class I; D007074:Immunoglobulin G
keywords: IgG anti HLA I autoantibodies; Kidney transplant