title: Anmindenols A and B, inducible nitric oxide synthase inhibitors from a marine-derived Streptomyces sp.
abstract: Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six-membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC50 values of 23 and 19 μM, respectively.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University , NS-80, Seoul 151-747, Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Tae Gu
authors.initials: TG
authors.lastname: Lee
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D007192:Indenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D007192:Indenes; D008070:Lipopolysaccharides; D016328:NF-kappa B; D012717:Sesquiterpenes; C000591096:anmindenol A; C000591097:anmindenol B; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II