title: A centrosomal route for cancer genome instability.
abstract: Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway - involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 - the alteration of which causes defective centrosome separation, aneuploidy and tumour development.
authors.affiliation: Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: de Cárcer
authors.affiliation: Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: Malumbres
mesh_terms: D000818:Animals; D018385:Centrosome / Q000378:metabolism*; D020090:Chromosome Segregation; D056765:Cyclin B2 / Q000378:metabolism*; D005260:Female; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C503759:Ccnb2 protein, mouse; D056765:Cyclin B2; D016159:Tumor Suppressor Protein p53