title: Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas.
abstract: To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with high-resolution and diffusion tensor MRIs. Automated demarcation of supratentorial fibers was accomplished with personalized fiber-labeled atlases. From the individual atlases, we observed significant elevation of mean diffusivity (MD) in fornix (cres)/stria terminalis (FX/ST) and sagittal stratum (SS) and a significant difference in fractional anisotropy (FA) among FX/ST, SS, posterior limb of the internal capsule (PLIC), and posterior thalamic radiation (PTR). For patients with early-onset epilepsy, the diffusivities of the SS and the retrolenticular part of the internal capsule were significantly elevated, and the anisotropies of the FX/ST and SS were significantly decreased. In the drug-resistant subgroup, the MDs of SS and PTR and the FAs of SS and PLIC were significantly different. Onset age was positively correlated with increases in FAs of the genu of the corpus callosum. Patients with neocortical seizures and secondary generalisation had microstructural anomalies in WM. The changes in WM are relevant to early onset, progression, and severity of epilepsy.
authors.affiliation: Department of Electrical Engineering, National Central University, Jhongli, Taoyuan 32001, Taiwan.
authors.forename: Syu-Jyun
authors.initials: SJ
authors.lastname: Peng
authors.affiliation: Epilepsy Center, Buddhist Tzu Chi General Hospital, Hualian, Hualian 97002, Taiwan.
authors.forename: Tomor
authors.initials: T
authors.lastname: Harnod
authors.affiliation: Department of Electrical Engineering, National Central University, Jhongli, Taoyuan 32001, Taiwan.
authors.forename: Jang-Zern
authors.initials: JZ
authors.lastname: Tsai
authors.affiliation: Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
authors.forename: Chien-Chun
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
authors.forename: Ming-Dou
authors.initials: MD
authors.lastname: Ker
authors.affiliation: Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
authors.forename: Jun-Chern
authors.initials: JC
authors.lastname: Chiou
authors.affiliation: Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
authors.forename: Herming
authors.initials: H
authors.lastname: Chiueh
authors.affiliation: Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
authors.forename: Chung-Yu
authors.initials: CY
authors.lastname: Wu
authors.affiliation: Epilepsy Center, Buddhist Tzu Chi General Hospital, Hualian, Hualian 97002, Taiwan ; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan ; Department of Neurology, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
authors.forename: Yue-Loong
authors.initials: YL
authors.lastname: Hsin
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D004827:Epilepsy / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D012640:Seizures / Q000000981:diagnostic imaging* / Q000473:pathology