title: [Thrombin generation assays and their clinical application].
abstract: Thrombin is a key enzyme of the coagulation system, having both pro- and anticoagulant functions. Thus, the generation of thrombin is one of the most important steps in coagulation. Global haemostasis assay, the so-called thrombin generation test is appropriate for its assessment. Since thrombin generation is sensible for both pro- and anticoagulant processes it can be applied for the general characterisation of the risk of thrombosis and bleeding, too. Clinical studies confirmed augmented thrombin generation in patients with high risk of venous or arterial thrombosis. Anticoagulant therapy (also novel oral anticoagulant treatment) can be monitored by thrombin generation. In case of haemophilia thrombin generation assays reflect bleeding severity. It is applicable for monitoring of both conventional haemophilia treatment and inhibitor-bypassing therapy, which is needed when inhibitors develop in patients. Standardization of thrombin generation methods and determination of cut off values are required before its application in clinical practice.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Laboratóriumi Medicina Intézet Budapest Baross u. 48-52. 1047 Diagon Kft. Budapest.
authors.forename: Anita
authors.initials: A
authors.lastname: Kern
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Laboratóriumi Medicina Intézet Budapest Baross u. 48-52. 1047.
authors.forename: Katalin
authors.initials: K
authors.lastname: Várnai
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Laboratóriumi Medicina Intézet Budapest Baross u. 48-52. 1047.
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D020147:Coagulation Protein Disorders / Q000097:blood / Q000175:diagnosis*; D006470:Hemorrhage; D006490:Hemostatics / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D013917:Thrombin / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology; D013918:Thrombin Time; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006490:Hemostatics; D013917:Thrombin
keywords: blood coagulation disorders; blood coagulation tests; thrombin; thrombosis; trombin; trombózis; véralvadási vizsgálatok; vérzékenység