title: Using generic preference-based measures in mental health: psychometric validity of the EQ-5D and SF-6D.
abstract: BACKGROUND
  Generic preference-based measures (EuroQoL-5D (EQ-5D) and SF-6D) are used in the economic evaluation of mental health interventions. However, there are inconsistent findings regarding their psychometric properties.
  
  
  OBJECTIVE
  To investigate the psychometric properties of the EQ-5D and SF-6D in different mental health conditions, using seven existing data-sets.
  
  
  METHODS
  The construct validity and responsiveness of the measures were assessed in comparison with condition-specific indicators.
  
  
  RESULTS
  Evidence for construct validity and responsiveness in common mental health and personality disorders was found (correlations 0.22-0.64; effect sizes 0.37-1.24; standardised response means 0.45-1.31). There was some evidence for validity in schizophrenia (correlations 0.05-0.43), but responsiveness was unclear.
  
  
  CONCLUSIONS
  EQ-5D and SF-6D can be used in the economic evaluation of interventions for common mental health problems with some confidence. In schizophrenia, a preference-based measure focused on the impact of mental health should be considered.
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: Brendan
authors.initials: B
authors.lastname: Mulhern
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: Clara
authors.initials: C
authors.lastname: Mukuria
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Barkham
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Knapp
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Byford
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: Djøra
authors.initials: D
authors.lastname: Soeteman
authors.affiliation: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
authors.forename: John
authors.initials: J
authors.lastname: Brazier
mesh_terms: D003362:Cost-Benefit Analysis; D006801:Humans; D008603:Mental Health; D008605:Mental Health Services / Q000191:economics*; D010554:Personality Disorders / Q000191:economics / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011788:Quality of Life; D012559:Schizophrenia / Q000191:economics / Q000628:therapy*