title: Synaptic dynamics: linear model and adaptation algorithm.
abstract: In this research, temporal processing in brain neural circuitries is addressed by a dynamic model of synaptic connections in which the synapse model accounts for both pre- and post-synaptic processes determining its temporal dynamics and strength. Neurons, which are excited by the post-synaptic potentials of hundred of the synapses, build the computational engine capable of processing dynamic neural stimuli. Temporal dynamics in neural models with dynamic synapses will be analyzed, and learning algorithms for synaptic adaptation of neural networks with hundreds of synaptic connections are proposed. The paper starts by introducing a linear approximate model for the temporal dynamics of synaptic transmission. The proposed linear model substantially simplifies the analysis and training of spiking neural networks. Furthermore, it is capable of replicating the synaptic response of the non-linear facilitation-depression model with an accuracy better than 92.5%. In the second part of the paper, a supervised spike-in-spike-out learning rule for synaptic adaptation in dynamic synapse neural networks (DSNN) is proposed. The proposed learning rule is a biologically plausible process, and it is capable of simultaneously adjusting both pre- and post-synaptic components of individual synapses. The last section of the paper starts with presenting the rigorous analysis of the learning algorithm in a system identification task with hundreds of synaptic connections which confirms the learning algorithm's accuracy, repeatability and scalability. The DSNN is utilized to predict the spiking activity of cortical neurons and pattern recognition tasks. The DSNN model is demonstrated to be a generative model capable of producing different cortical neuron spiking patterns and CA1 Pyramidal neurons recordings. A single-layer DSNN classifier on a benchmark pattern recognition task outperforms a 2-Layer Neural Network and GMM classifiers while having fewer numbers of free parameters and decides with a shorter observation of data. DSNN performance in the benchmark pattern recognition problem shows 96.7% accuracy in classifying three classes of spiking activity.
authors.affiliation: Department of Electrical Engineering, University of Southern California, DRB 140, 1042 Downey Way, Los Angeles, CA, 90089-1111, United States. Electronic address: ayousefi@usc.edu.
authors.forename: Ali
authors.initials: A
authors.lastname: Yousefi
authors.affiliation: Department of Biomedical Engineering, University of Southern California, DRB 384, 1042 Downey Way, Los Angeles, CA, 90089-1111, United States. Electronic address: dibazar@usc.edu.
authors.forename: Alireza A
authors.initials: AA
authors.lastname: Dibazar
authors.affiliation: Department of Biomedical Engineering, University of Southern California, DRB 140, 1042 Downey Way, Los Angeles, CA, 90089-1111, United States. Electronic address: berger@usc.edu.
authors.forename: Theodore W
authors.initials: TW
authors.lastname: Berger
mesh_terms: D000200:Action Potentials; D000222:Adaptation, Physiological; D000465:Algorithms; D001921:Brain / Q000502:physiology*; D056547:CA1 Region, Hippocampal / Q000502:physiology; D007858:Learning / Q000502:physiology; D016014:Linear Models; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009474:Neurons / Q000502:physiology*; D017711:Nonlinear Dynamics; D010363:Pattern Recognition, Automated / Q000379:methods; D017966:Pyramidal Cells / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D055366:Synaptic Potentials; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000502:physiology; D013997:Time Factors
keywords: Bio-inspired models; Learning; Plasticity; Spiking neural networks