title: Once-weekly teriparatide increases bone mineral density in the distal 1/10 radius, but not in the distal 1/3 radius.
abstract: Teriparatide significantly increases bone mineral density (BMD) of the lumbar vertebrae and femur and has a strong effect in reducing the risk of bone fractures. However, few detailed investigations with dual-energy X-ray absorptiometry (DXA) of the effects of teriparatide on the radius have been reported; specifically, there are no reports of the use of once-weekly teriparatide. In this study, the effect of once-weekly teriparatide in increasing BMD was examined in the distal 1/10 of the radius and the distal 1/3 of the radius using a DXA system for the radius. In addition, the effect of radius positioning, especially accurate correction of rotation and inclination before and after administration of teriparatide, was evaluated in an assessment of its efficacy. It was found that when positioning was corrected, a significant increase in BMD in the distal 1/10 of the radius was observed after 6 months of once-weekly teriparatide. In the distal 1/3 of the radius, no significant increase of BMD was observed. This suggests that when DXA scans of the radius are analyzed with appropriate positioning, weekly teriparatide significantly increases BMD in the distal 1/10 of the radius, which is rich in cancellous bone.
authors.affiliation: Department of Orthopedic Surgery, Nukada Memorial Hospital, 4-6-6 Omachi, Kamakura, Kanagawa, 248-0007 Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Urushibara
authors.affiliation: Project for Bone Metabolic Disease, Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo, 101-8101 Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kato
authors.affiliation: Hitachi Aloka Medical, Ltd, 3-7-19 Imai, Ome-shi, Tokyo, 198-8577 Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Adachi
authors.affiliation: Project for Bone Metabolic Disease, Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo, 101-8101 Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Project for Bone Metabolic Disease, Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo, 101-8101 Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Mihara
authors.affiliation: Project for Bone Metabolic Disease, Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo, 101-8101 Japan.
authors.forename: Toyonobu
authors.initials: T
authors.lastname: Uzawa
authors.affiliation: Hitachi Aloka Medical, Ltd, 3-7-19 Imai, Ome-shi, Tokyo, 198-8577 Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kitagawa
authors.affiliation: Project for Bone Metabolic Disease, Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo, 101-8101 Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: Project for Bone Metabolic Disease, Asahi Kasei Pharma Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo, 101-8101 Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kuroda
authors.affiliation: Department of Nuclear Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192 Japan.
authors.forename: Teruki
authors.initials: T
authors.lastname: Sone
keywords: Bone mineral density; Distal radius; Dual X-ray absorptiometry; Osteoporosis; Teriparatide