title: Antiviral defense in shrimp: from innate immunity to viral infection.
abstract: The culture of penaeid shrimp is rapidly developing as a major business endeavor worldwide. However, viral diseases have caused huge economic loss in penaeid shrimp culture industries. Knowledge of shrimp innate immunity and antiviral responses has made important progress in recent years, allowing the design of better strategies for the prevention and control of shrimp diseases. In this study, we have updated information on shrimp antiviral immunity and interactions between shrimp hosts and viral pathogens. Current knowledge and recent progress in immune signaling pathways (e.g., Toll/IMD-NF-κB and JAK-STAT signaling pathways), RNAi, phagocytosis, and apoptosis in shrimp antiviral immunity are discussed. The mechanism of viral infection in shrimp hosts and the interactions between viruses and shrimp innate immune systems are also analyzed.
authors.affiliation: MOE Key Laboratory of Aquatic Product Safety/State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, 135 Xingang Road West, Guangzhou 510275, People's Republic of China.
authors.forename: Pei-Hui
authors.initials: PH
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
authors.forename: Tianzhi
authors.initials: T
authors.lastname: Huang
authors.affiliation: College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China. Electronic address: zxb0812@zju.edu.cn.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of Aquatic Product Safety/State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, 135 Xingang Road West, Guangzhou 510275, People's Republic of China; School of Marine Sciences, Sun Yat-Sen University, 135 Xingang Road West, Guangzhou 510275, People's Republic of China. Electronic address: lsshjg@mail.sysu.edu.cn.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: He
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D033561:Penaeidae / Q000276:immunology*; D015398:Signal Transduction; D014780:Viruses / Q000276:immunology*
keywords: Antiviral immunity; Apoptosis; Phagocytosis; RNAi; Shrimp; White spot syndrome virus