title: Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel.
abstract: Hydrogel has been used for regenerating myocardial infraction (MI) as a delivery vehicle for cells and growth factors. This study showed that injectable hyaluronic acid (HA)-based hydrogels alone would effectively regenerate the damaged infarcted heart tissue. We found that there are two major factors of regeneration in MI. One is molecular weight of HA and another is the progression of MI; sub-acute and chronic. Rat MI model was prepared by ligating the left anterior descending coronary artery (LAD). Four weeks after injection of hydrogel, functional analysis of the heart and histological analysis was assessed. When different molecular weight HA-based hydrogels with 50 kDa, 130 kDa, and 170 kDa were applied to the infarcted area in the sub-acute model, 50 kDa HA-based hydrogel showed the most significant regeneration of myocardium as well as functional recovery among samples. For the disease progression, 50 kDa HA-based hydrogels were injected to sub-acute and chronic MI models. The regeneration activity was significantly decreased in the chronic models reflecting that injection timing of the therapeutic agents is also major determinants in the regeneration process. These results suggest that injection time and composition of hydrogel are two major points treating MI.
authors.affiliation: Korea Artificial Organ Center, Korea University, Seoul 136-705, Republic of Korea; Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: So Jeong
authors.initials: SJ
authors.lastname: Yoon
authors.affiliation: Korea Artificial Organ Center, Korea University, Seoul 136-705, Republic of Korea; Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: Yong Hu
authors.initials: YH
authors.lastname: Fang
authors.affiliation: Korea Artificial Organ Center, Korea University, Seoul 136-705, Republic of Korea; Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: Myeongjin
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 406-799, Republic of Korea.
authors.forename: Kuk Hui
authors.initials: KH
authors.lastname: Son
authors.affiliation: Korea Artificial Organ Center, Korea University, Seoul 136-705, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Son
authors.affiliation: Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: Sook Kyoung
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Korea Artificial Organ Center, Korea University, Seoul 136-705, Republic of Korea; Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul 136-705, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Medical College, Korea University, Seoul 136-705, Republic of Korea.
authors.forename: Kyung
authors.initials: K
authors.lastname: Sun
authors.affiliation: Korea Artificial Organ Center, Korea University, Seoul 136-705, Republic of Korea; Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul 136-705, Republic of Korea. Electronic address: ydpark@kumc.or.kr.
authors.forename: Yongdoo
authors.initials: Y
authors.lastname: Park
mesh_terms: D000208:Acute Disease; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006820:Hyaluronic Acid / Q000737:chemistry / Q000494:pharmacology*; D020100:Hydrogels; D008297:Male; D008970:Molecular Weight; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D012038:Regeneration / Q000187:drug effects*; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D020100:Hydrogels; D006820:Hyaluronic Acid
keywords: Chronic myocardial infarction; Heart function; Hyaluronic acid; Injectable hydrogel; Molecular weight; Tissue regeneration