title: Protective Effects of Bu-Shen-Huo-Xue Formula against 5/6 Nephrectomy-Induced Chronic Renal Failure in Rats.
abstract: Chronic renal failure (CRF) is a serious disease related to increasing incidence and prevalence as well as decline in quality of life. Bu-Shen-Huo-Xue formula (BSHX), one of traditional herbal formulations, has been clinically employed to treat CRF for decades, but the mechanisms involved have not been investigated. In the present study, we investigated the effects of BSHX on some closely related parameters in 5/6 nephrectomy CRF rats. Rats with CRF were divided into five groups, namely, one control group, one enalapril group, and three BSHX treatment groups (0.25, 0.5, and 1 g/kg·d). The rats subjected to sham operation were used as a normal control. After eight weeks of treatment, BSHX significantly decreased the levels of Scr and BUN, downregulated the mRNA expression levels of TGF-β 1, CTGF, NF-κB, TNF-α, and OPN, upregulated the mRNA expression of PPARγ, and reduced in situ expression of fibronectin and laminins. Histological findings also showed significant amelioration of the damaged renal tissue. BSHX protects 5/6 nephrectomy rats against chronic renal failure probably via regulating the expression of TNF-α, NF-κB, TGF-β 1, CTGF, PPARγ, OPN, fibronectin, and laminins and is useful for therapy of CRF.
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Jian-Rao
authors.initials: JR
authors.lastname: Lu
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Han
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Chong-Xiang
authors.initials: CX
authors.lastname: Xiong
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Division of Nephrology, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Chen
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ma