title: Incidence of neoplasms in the most prevalent autoimmune rheumatic diseases: a systematic review.
abstract: This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used in the treatment of autoimmune diseases. A search was conducted of scientific articles indexed in the Cochrane / BVS, Pubmed / Medline and Scielo / Lilacs in the period from 2002 to 2012. Also consulted was the IB-ICT (Brazilian digital library of theses and Masters), with descriptors in Portuguese and English for "Systemic sclerosis", "Rheumatoid Arthritis", " Systemic Lupus Erythematosus" and "Sjögren's syndrome", correlating each one with the descriptor AND "neoplasms". The results showed that in the database IBICT a thesis and a dissertation for the descriptor SLE met the inclusion criteria, none met RA one thesis to SS. Lilacs in the database/Scielo found two articles on "Rheumatoid Arthritis" AND "neoplasms". In Pubmed/Medline the inicial search resulted in 118 articles, and 41 were selected. The review noted the relationship between cancer and autoimmune rheumatic diseases, as well as a risk factor for protection, although the pathophysiological mechanisms are not known.
authors.affiliation: Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
authors.forename: Roberta Ismael Lacerda
authors.initials: RI
authors.lastname: Machado
authors.affiliation: Departamento de Medicina Interna, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
authors.forename: Alessandra de Sousa
authors.initials: Ade S
authors.lastname: Braz
authors.affiliation: Departamento de Medicina Interna, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
authors.forename: Eutilia Andrade Medeiros
authors.initials: EA
authors.lastname: Freire
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D015995:Prevalence; D012216:Rheumatic Diseases / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000150:complications