title: Intracranial idiopathic hypertension: 1-year follow-up study.
abstract: Standard guidelines for ongoing management, as well as definitive data about the long-term course of idiopathic intracranial hypertension (IIH) are not available. The aim of this study was to compare several clinical and instrumental variables as assessed at the time of diagnosis and then after 1 year in a sample of IIH patients. A total of 21 patients were studied. Our results confirmed that headache and TVO are the most frequent symptoms in IIH patients, and that overweight is a very common feature. A trend towards a favorable outcome in patients followed for 1 year and treated by usual medical therapy was found: intracranial pressure was lower at follow-up; improvement of headache and transient visual obscurations, as well as of papilledema, was reported in most patients. On the other hand, neuroradiological findings (such as empty sella, perioptic subarachnoid space distension, narrowing of the transverse sinuses) were substantially stable at follow. These findings may be relevant for future research as far as understanding the role of different clinical and instrumental findings as diagnostic items as well as predictors of outcome in IIH.
authors.affiliation: Neurological Institute C. Besta, IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy, damico.d@istituto-besta.it.
authors.forename: D
authors.initials: D
authors.lastname: D'Amico
authors.forename: M
authors.initials: M
authors.lastname: Curone
authors.forename: A
authors.initials: A
authors.lastname: Erbetta
authors.forename: G
authors.initials: G
authors.lastname: Farago'
authors.forename: S
authors.initials: S
authors.lastname: Bianchi-Marzoli
authors.forename: P
authors.initials: P
authors.lastname: Ciasca
authors.forename: G
authors.initials: G
authors.lastname: Bussone
authors.forename: L
authors.initials: L
authors.lastname: Chiapparini
mesh_terms: D000086:Acetazolamide / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D015992:Body Mass Index; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000503:physiopathology; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011559:Pseudotumor Cerebri / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D054064:Transverse Sinuses / Q000473:pathology; D016896:Treatment Outcome; D014786:Vision Disorders / Q000503:physiopathology; D055815:Young Adult
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide