title: Prenatal treatment with 6-hydroxydopa and DSP 4: Biochemical, endocrinological and behavioural effects.
abstract: Biochemical, hormonal, and behavioural aspects of the effects of prenatal treatment (foetal days 18 and 19) with 6-hydroxydopa (2 × 40 mg/kg) and DSP 4 (2 × 20 mg/kg) have been studied in the rat. The results of the catecholamine assays suggest that the 6-hydroxydopa treatment produced a transient decrease of noradrenaline concentration in the cerebral cortex, and a long-lasting decrease in the cerebellum, whereas DSP 4 produced a long-lasting decrease in the cerebral cortex and a tendency towards increase in the cerebellum. Assays of adrenocorticotropic hormone and corticosterone indicated a general tendency towards increase in base line as well as in moderate stress situations. The results of behavioural tests indicated hyperactivity and/or hyperreactivity, but not restlessness, and partly supranormal sensorimotor performances.
authors.affiliation: Lab. of Neurophysiology, University of Montpellier II, France.
authors.forename: N
authors.initials: N
authors.lastname: König
authors.affiliation: Lab. of Pharmacodynamics, University of Montpellier I, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Serrano
authors.affiliation: Dept. of Histology, Karolinska Institute, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Jonsson
authors.affiliation: Lab. of Neuroendocrinology, ERA 85-CNRS, University of Montpellier II, France.
authors.forename: F
authors.initials: F
authors.lastname: Malayal
authors.affiliation: Lab. of Neuroendocrinology, ERA 85-CNRS, University of Montpellier II, France.
authors.forename: A
authors.initials: A
authors.lastname: Szafarczyk