title: [Role for PTHrP in bone and cartilage metabolism].
abstract: PTH-related peptide (PTHrP) is a widely distributed cytokine, which shares the cognate receptor PTHR1 with PTH. Originally identified as a causal factor of humoral hypercalcemia of malignancy twenty years ago, PTHrP is now recognized as a critical physiological regulator of various biological processes, including bone and cartilage metabolism.
authors.affiliation: Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000556:secondary; D001842:Bone and Bones / Q000378:metabolism*; D002356:Cartilage / Q000378:metabolism*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D051379:Mice; D009369:Neoplasms / Q000150:complications / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy; D010257:Paraneoplastic Syndromes / Q000209:etiology; D044162:Parathyroid Hormone-Related Protein / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000502:physiology
chemical_list: D044162:Parathyroid Hormone-Related Protein; D044168:Receptor, Parathyroid Hormone, Type 1