title: PML control of cytokine signaling.
abstract: The promyelocytic leukemia (PML) protein is a tumor suppressor acting as the organizer of nuclear matrix-associated structures named nuclear bodies (NBs). The involvement of PML in various cell processes, including cell death, senescence or antiviral defense underlines the multiple functions of PML due to its ability to interact with various partners either in the cytoplasm or in the nucleus. The importance of paracrine signaling in the regulation of PML expression is well established. More recently, a growing body of evidence also supports PML as a key regulator of cytokine signaling. These findings shed light on unsuspected biological functions of PML such as immune response, inflammation and cytokine-induced apoptosis. Here we review the current understanding of the pleiotropic activities of PML on cytokine-induced signaling.
authors.affiliation: INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saint-Pères, 75006 Paris, France.
authors.forename: Ghizlane
authors.initials: G
authors.lastname: Maarifi
authors.affiliation: INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saint-Pères, 75006 Paris, France.
authors.forename: Mounira K
authors.initials: MK
authors.lastname: Chelbi-Alix
authors.affiliation: INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saint-Pères, 75006 Paris, France. Electronic address: sebastien.nisole@inserm.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Nisole
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D000071156:Promyelocytic Leukemia Protein; D020033:Protein Isoforms / Q000235:genetics; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D016207:Cytokines; D058847:Inflammasomes; D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D020033:Protein Isoforms; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human
keywords: Cytokine signaling; Interferon; Nuclear bodies; PML; TRIM19