title: High prevalence of subtype F in newly diagnosed HIV-1 persons in northwest Spain and evidence for impaired treatment response.
abstract: HIV-1 non-B subtype variants were found in 37.8% of 296 newly diagnosed persons in northwest Spain over the past 5 years. Subtype F was the most prevalent non-B subtype (29.6%) and displayed preferential transmission among MSM. Virologic response rates to antiretroviral therapy were lower among F subtypes compared to B subtypes at weeks 24 (31% vs. 78.3%), 48 (51.7% vs. 85.2%), and 96 (61.1% vs. 94.3%) of therapy. Subtype F was independently associated with virological response at 24 weeks.
authors.affiliation: aGrupo de Virología Clínica bServicio de Microbiología cUnidad de Epidemiología Clínica y Bioestadística, INIBIC-Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain dDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, USA.
authors.forename: Berta
authors.initials: B
authors.lastname: Pernas
authors.forename: Marta
authors.initials: M
authors.lastname: Grandal
authors.forename: Alvaro
authors.initials: A
authors.lastname: Mena
authors.forename: Angeles
authors.initials: A
authors.lastname: Castro-Iglesias
authors.forename: Angelina
authors.initials: A
authors.lastname: Cañizares
authors.forename: David L
authors.initials: DL
authors.lastname: Wyles
authors.forename: Soledad
authors.initials: S
authors.lastname: López-Calvo
authors.forename: Sonia
authors.initials: S
authors.lastname: Pértega
authors.forename: Iria
authors.initials: I
authors.lastname: Rodríguez-Osorio
authors.forename: Jose Domingo
authors.initials: JD
authors.lastname: Pedreira
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents