title: Evaluation of acotiamide for the treatment of functional dyspepsia.
abstract: BACKGROUND
  The treatment for functional dyspepsia (FD) (indigestion) remains unsatisfactory. Acotiamide is a new prokinetic that has been recently approved and used in Japan for the treatment of FD.
  
  
  METHODS
  This review introduces the pharmacodynamics, pharmacokinetics and efficacy data from current clinical trials from literature sourced using the PubMed search tools. Future principles for developing drugs and designing clinical trials to test them for treating FD are also discussed.
  
  
  CONCLUSIONS
  Acotiamide can contribute to the treatment of the specific subset of symptoms defined as postprandial FD by reducing the impaired fundic relaxation and accommodation after eating. The agent has the added benefit of a very good safety profile.
authors.affiliation: Texas Tech University and Health Science Center, Internal Medicine Department , 4800 Albert Avenue, El Paso, TX 79905 , USA +1 915 5456 627 ; +1 915 545 9765 ; richard.mccallum@ttuhsc.edu.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Gengqing
authors.initials: G
authors.lastname: Song
authors.forename: Richard W
authors.initials: RW
authors.lastname: McCallum
mesh_terms: D000818:Animals; D001549:Benzamides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D017277:Drug Approval; D015195:Drug Design; D004415:Dyspepsia / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007564:Japan; D019518:Postprandial Period; D013844:Thiazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D013844:Thiazoles; C410959:Z 338
keywords: acotiamide; functional dyspepsia