title: Novel aspects of RNA regulation in Staphylococcus aureus.
abstract: A plethora of RNAs with regulatory functions has been discovered in many non-pathogenic and pathogenic bacteria. In Staphylococcus aureus, recent findings show that a large variety of RNAs control target gene expression by diverse mechanisms and many of them are expressed in response to specific internal or external signals. These RNAs comprise trans-acting RNAs, which regulate gene expression through binding with mRNAs, and cis-acting regulatory regions of mRNAs. Some of them possess multiple functions and encode small but functional peptides. In this review, we will present several examples of RNAs regulating pathogenesis, antibiotic resistance, and host-pathogen interactions and will illustrate how regulatory proteins and RNAs form complex regulatory circuits to express the virulence factors in a dynamic manner.
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fechter
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Caldelari
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg, France.
authors.forename: Efthimia
authors.initials: E
authors.lastname: Lioliou
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg, France. Electronic address: p.romby@ibmc-cnrs.unistra.fr.
authors.forename: Pascale
authors.initials: P
authors.lastname: Romby
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D053038:Quorum Sensing / Q000235:genetics; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity / Q000502:physiology; D014158:Transcription, Genetic; D014774:Virulence / Q000235:genetics
chemical_list: D012329:RNA, Bacterial
keywords: Post-transcriptional regulation; Regulatory RNAs; Staphylococcus aureus; Virulence