title: Hypothalamic testosterone increase in the male rat at birth.
abstract: In the male rat, a dramatic increase in serum testosterone occurs during the first 2 h of postnatal life. Since the hypothalamus is known to be an important site for sexual differentiation of the brain, this early testosterone surge was a good model to use to study the transfer of serum testosterone to the hypothalamus and cerebral cortex. Endogenous testosterone was measured by radioimmunoassay in the hypothalamus and the cerebral cortex of the foetus and newborn rats during the first 6 h following birth. In the male, hypothalamic testosterone increased between 0 h in utero and 2 h; in the males gonadectomized at 0 h in utero and killed at the age of 2 h, the testosterone surge was abolished, clearly indicating the testicular origin of this hormone in the neonate. The small testosterone increase in the cerebral cortex compared with that in the hypothalamus reflects a preferential uptake of this hormone by the hypothalamus of the newborn. In the female, hypothalamic testosterone slightly decreased between 0 h in utero and 6 h. These results are in agreement with the view that hypothalamic modifications form the basis for some behavioral and physiological changes attributed to the effect of perinatal hormonal stimulation.
authors.affiliation: Laboratoire d'Endocrinologie, Centre d'Orsay, Université de Paris XI, F 91405 Orsay Cédex, France.
authors.forename: J
authors.initials: J
authors.lastname: Rhoda
authors.forename: P
authors.initials: P
authors.lastname: Corbier
authors.forename: J
authors.initials: J
authors.lastname: Roffi