title: Chinese SLE treatment and research group registry: III. association of autoantibodies with clinical manifestations in Chinese patients with systemic lupus erythematosus.
abstract: We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; between anti-RNP antibody, anti-SSA antibody, and pulmonary arterial hypertension (PAH); between anti-SSB antibody and hematologic involvement; and between anti-dsDNA antibody and nephropathy. APL antibody was associated with hematologic involvement, interstitial lung disease, and a lower prevalence of oral ulcerations (P<0.05). Associations were also found between anti-dsDNA antibody and a lower prevalence of photosensitivity, and between anti-SSA antibody and a lower prevalence of nephropathy (P<0.05). Most of these findings were consistent with other studies in the literature but this study is the first report on the association between anti-SSA and a lower prevalence of nephropathy. The correlations of specific autoantibodies and clinical manifestations could provide clues for physicians to predict organ damages in SLE patients. We suggest that a thorough screening of autoantibodies should be carried out when the diagnosis of SLE is established, and repeated echocardiography annually in SLE patients with anti-RNP or anti-SSA antibody should be performed.
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Jing
authors.identifier: 0000-0003-2504-1629
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Leng
authors.affiliation: Department of Rheumatology, The Affiliated Hospital of Bengbu Medical College, No. 2600 Do Hai Da Dao, Anhui 233030, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Rheumatology, The Fourth People's Hospital of Shenzhen Affiliated to Guangdong Medical College, No. 22 Nong Lin Lu, Guangdong 518034, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Rheumatology, Beijing Children's Hospital Affiliated to Capital Medical University, No. 56 Nan Li Shi Lu, Beijing 100045, China.
authors.forename: Caifeng
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Rheumatology, The Second Hospital of Shanxi Medical University, No. 382 Wu Yi Lu, Shanxi 030001, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Clinical Immunology and Rheumatology, Xijing Hospital Affiliated to the Fourth Military Medical University, No. 15 Chang Le Xi Lu, Shanxi 710032, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of Rheumatology, Beijing Tongren Hospital Affiliated to Capital Medical University, No. 1 Dong Jiao Min Xiang, Beijing 100730, China.
authors.forename: Zhengang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, Beijing Chao-yang Hospital Affiliated to Capital Medical University, No. 8 Gong Ti Nan Lu, Beijing 100020, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Rheumatology, Anhui Provincial Hospital, No. 17 Lu Jiang Lu, Anhui 230001, China.
authors.forename: Xiangpei
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Rheumatology, Jiangsu Provincial People's Hospital, No. 30 Guang Zhou Lu, Jiangsu 210029, China.
authors.forename: Miaojia
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Tian
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Mengtao
authors.initials: M
authors.lastname: Li
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Jiuliang
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Feng-Chun
authors.initials: FC
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China ; Department of Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: Xiaofeng
authors.identifier: 0000-0001-9484-8093
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001323:Autoantibodies / Q000097:blood* / Q000145:classification; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000276:immunology / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000208:ethnology / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000276:immunology / Q000503:physiopathology; D019226:Oral Ulcer / Q000276:immunology / Q000503:physiopathology; D010787:Photosensitivity Disorders / Q000276:immunology / Q000503:physiopathology; D012042:Registries; D012720:Severity of Illness Index
chemical_list: D001323:Autoantibodies