title: RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases.
abstract: The transition between initiation and productive elongation during RNA Polymerase II (Pol II) transcription is a well-appreciated point of regulation across many eukaryotes. Elongating Pol II is modified by phosphorylation of serine 2 (Ser2) on its carboxy terminal domain (CTD) by two kinases, Bur1/Ctk1 in yeast and Cdk9/Cdk12 in metazoans. Here, we discuss the roles and regulation of these kinases and their relationship to Pol II elongation control, and focus on recent data from work in C. elegans that point out gaps in our current understand of transcription elongation.
authors.affiliation: National Institute of Environmental Health Sciences; Research Triangle Park, NC USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Bowman
authors.affiliation: Department of Biology; Emory University; Atlanta, GA USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Kelly
mesh_terms: D000818:Animals; D042863:Cyclin-Dependent Kinase 9 / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation / Q000235:genetics*; D012319:RNA Polymerase II / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D012694:Serine; D042863:Cyclin-Dependent Kinase 9; D018844:Cyclin-Dependent Kinases; D012319:RNA Polymerase II
keywords: Bur1; C. elegans; Cdk12; Cdk9; Ctk1; P-TEFb; RNA Polymerase II; Serine 2; elongation; transcription