title: Human pluripotent stem cell strategies for age-related macular degeneration.
abstract: Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the Western world and is increasing exponentially as the population ages. Despite enormous worldwide efforts, the earliest pathogenic pathways involved in AMD are still not fully understood. It is essential to develop research tools for effective modeling of AMD pathogenesis and for subsequent drug discovery and cell or molecular therapies. This review will focus on the current progress in human pluripotent stem cells for understanding and treating AMD.
authors.affiliation: *PhD †MD, PhD Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, and Department of Ophthalmology, the University of Melbourne, East Melbourne, Australia (KCD, RHG, AP); and Department of Anatomy and Neurosciences, the University of Melbourne, The Florey Institute of Neuroscience and Mental Health, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia (MFP).
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Davidson
authors.forename: Robyn H
authors.initials: RH
authors.lastname: Guymer
authors.forename: Martin F
authors.initials: MF
authors.lastname: Pera
authors.forename: Alice
authors.initials: A
authors.lastname: Pébay
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000637:transplantation*; D033581:Stem Cell Transplantation