title: Acquired factor X deficiency developed four years after autologous transplantation in a patient with multiple myeloma associated with systemic AL amyloidosis.
abstract: We describe a case of acquired factor X deficiency after high-dose melphalan with autologous stem cell transplantation (HDM/ASCT) for multiple myeloma (MM) with systemic AL amyloidosis. A 68-year-old woman with renal amyloidosis was diagnosed as having MM in 2007. She achieved a partial response after VAD (vincristine, adriamycin, dexamethasone) therapy and HDM/ASCT. In December 2011, coagulation tests revealed a prolonged prothrombin time (PT) of 17.6 sec and she was administered vitamin K. In January 2012, she received low anterior resection with colostomy for rectal cancer. She received fresh frozen plasma (FFP) infusion but the perioperative bleeding tendency persisted. In February 2012, she was referred from surgery for colostomy closure. She showed no progression of MM and had prolonged PT, corrected by mixing with normal plasma. Factor X activity was markedly decreased. She was diagnosed as having an acquired factor X deficiency and was given FFP infusion for colostomy closure. Although acquired factor X deficiency after HDM/ASCT for MM with systemic AL amyloidosis is rare, we should be aware of the possibility of this disease in MM patients with a bleeding tendency.
authors.affiliation: Oncology Center, Hamamatsu University School of Medicine.
authors.forename: Tomonari
authors.initials: T
authors.lastname: Takemura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Fukatsu
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nagata
authors.forename: Aya
authors.initials: A
authors.lastname: Asahina
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yokota
authors.forename: Isao
authors.initials: I
authors.lastname: Hirano
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yagyu
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ono
authors.forename: Akira
authors.initials: A
authors.lastname: Katsumi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ohnishi
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005171:Factor X Deficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D014182:Transplantation, Autologous / Q000009:adverse effects*; D016896:Treatment Outcome