title: Beyond consent in research. Revisiting vulnerability in deep brain stimulation for psychiatric disorders.
abstract: Vulnerability is an important criterion to assess the ethical justification of the inclusion of participants in research trials. Currently, vulnerability is often understood as an attribute inherent to a participant by nature of a diagnosed condition. Accordingly, a common ethical concern relates to the participant's decisionmaking capacity and ability to provide free and informed consent. We propose an expanded view of vulnerability that moves beyond a focus on consent and the intrinsic attributes of participants. We offer specific suggestions for how relational aspects and the dynamic features of vulnerability could be more fully captured in current discussions and research practices.
authors.forename: Emily
authors.initials: E
authors.lastname: Bell
authors.forename: Eric
authors.initials: E
authors.lastname: Racine
authors.forename: Paula
authors.initials: P
authors.lastname: Chiasson
authors.forename: Maya
authors.initials: M
authors.lastname: Dufourcq-Brana
authors.forename: Laura B
authors.initials: LB
authors.lastname: Dunn
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Fins
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Ford
authors.forename: Walter
authors.initials: W
authors.lastname: Glannon
authors.forename: Nir
authors.initials: N
authors.lastname: Lipsman
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Macdonald
authors.forename: Debra J H
authors.initials: DJ
authors.lastname: Mathews
authors.forename: Mary Pat
authors.initials: MP
authors.lastname: McAndrews
mesh_terms: D002986:Clinical Trials as Topic; D003657:Decision Making / Q000941:ethics; D046690:Deep Brain Stimulation / Q000941:ethics*; D032984:Ethics, Research; D006801:Humans; D007258:Informed Consent / Q000941:ethics*; D001523:Mental Disorders / Q000628:therapy; D018579:Patient Selection / Q000941:ethics*; D018570:Risk Assessment