title: Tumor-to-tumor metastasis: report of two cases of renal cell carcinoma metastasizing to microcystic serous cystadenoma of the pancreas.
abstract: Metastatic cancer to the pancreas accounts for less than 2% of all pancreatic malignancies. In contrast to other metastatic tumors, renal cell carcinoma (RCC) has a propensity to metastasize as a solitary pancreatic lesion. While symptomatic patients may present with obstructive jaundice, abdominal pain, or gastrointestinal bleeding, the diagnosis of metastatic pancreatic involvement is often made in asymptomatic patients, during follow-up evaluation in the aftermath of an initial diagnosis of renal cell carcinoma. Microcystic serous cystadenoma of the pancreas is an uncommon pancreatic exocrine neoplasm that morphologically resembles conventional (clear cell) RCC, in so far as both tumors are characterized by neoplastic cells with clear cytoplasm, relatively uniform nuclei and scant associated tumor stroma. Herein, we report 2 immunohistochemically confirmed cases of unsuspected metastatic RCC to the pancreas, with the metastatic tumor in each case confined to a preexisting microcystic serous cystadenoma of the pancreas.
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA.
authors.forename: Lopa
authors.initials: L
authors.lastname: Shah
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Tiesi
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA.
authors.forename: Zubin
authors.initials: Z
authors.lastname: Bamboat
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: McCain
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Siegel
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA cmannion@hackensackumc.org.
authors.forename: Ciaran
authors.initials: C
authors.lastname: Mannion
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary*; D018293:Cystadenoma, Serous / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000556:secondary
keywords: metastatic renal cell carcinoma; microcystic serous cystadenoma of pancreas; tumor-to-tumor metastasis