title: CXCL16 in kidney and cardiovascular injury.
abstract: CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. Conflicting results were reported for experimental cardiovascular injury. High circulating CXCL16 levels are associated to human kidney and cardiovascular disease and urinary CXCL16 may increase in kidney injury. In conclusion, mounting evidence suggests a role of CXCL16 in kidney and cardiovascular disease. However, a better understanding is still required before exploring CXCL16 targeting in the clinic.
authors.affiliation: IIS-Fundacion Jimenez Diaz, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address: cizquierdo@fjd.es.
authors.forename: María Concepción
authors.initials: MC
authors.lastname: Izquierdo
authors.affiliation: IIS-Fundacion Jimenez Diaz, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address: cmartinc@fjd.es.
authors.forename: Catalina
authors.initials: C
authors.lastname: Martin-Cleary
authors.affiliation: IIS-Fundacion Jimenez Diaz, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address: bfernandez@fjd.es.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fernandez-Fernandez
authors.affiliation: IIS-Fundacion Jimenez Diaz, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address: usamaelewa@gmail.com.
authors.forename: Usama
authors.initials: U
authors.lastname: Elewa
authors.affiliation: REDINREN, Madrid, Spain; IDIPAZ, Madrid, Spain. Electronic address: dolores.sanchez@idipaz.es.
authors.forename: María D
authors.initials: MD
authors.lastname: Sanchez-Niño
authors.affiliation: Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden. Electronic address: juan.jesus.carrero@ki.se.
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Carrero
authors.affiliation: IIS-Fundacion Jimenez Diaz, Madrid, Spain; REDINREN, Madrid, Spain; Universidad Autonoma de Madrid and FRIAT/IRSIN, Madrid, Spain. Electronic address: aortiz@fjd.es.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000473:pathology; D015815:Cell Adhesion Molecules; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D007678:Kidney Glomerulus / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D051116:Receptors, Scavenger / Q000378:metabolism*
chemical_list: C423727:CXCL16 protein, human; D015815:Cell Adhesion Molecules; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger
keywords: Atherosclerosis; Chemokine; Chronic kidney disease; Inflammation