title: A prospective antibacterial for drug-resistant pathogens: a dual warhead amphiphile designed to track interactions and kill pathogenic bacteria by membrane damage and cellular DNA cleavage.
abstract: A rationally designed bactericidal amphiphile acts on compelling targets and has the potential to disarm resistance development in pathogenic bacteria.
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India. aramesh@iitg.ernet.in.
authors.forename: Durairaj
authors.initials: D
authors.lastname: Thiyagarajan
authors.forename: Sudeep
authors.initials: S
authors.lastname: Goswami
authors.forename: Chirantan
authors.initials: C
authors.lastname: Kar
authors.forename: Gopal
authors.initials: G
authors.lastname: Das
authors.forename: Aiyagari
authors.initials: A
authors.lastname: Ramesh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects* / Q000473:pathology; D053837:DNA Cleavage / Q000187:drug effects*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D011446:Prospective Studies; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013501:Surface-Active Agents