title: Rheumatoid arthritis/methotrexate-associated primary cutaneous diffuse large B-cell lymphoma, leg type.
abstract: This report concerns a 62-year-old man with primary cutaneous diffuse large B-cell lymphoma (PCLBCL), leg type that developed during methotrexate (MTX) treatment for rheumatoid arthritis (RA). Several tumors were observed on the left lower leg. A histological analysis showed diffuse proliferation of large neoplastic B-cells that were immunophenotypically CD10-/MUM1+/BCL6-/BCL2+ and cytogenetically had IgH/c-MYC translocation without translocation involving BCL6 or IgH/BCL2. No evidence of Epstein-Barr virus (EBV) infection was found. The discontinuation of MTX resulted in a 20-month disease-free period. No previous cases of PCLBCL, leg type associated with RA or MTX therapy have been reported. The phenotypes of our patient were partly different from those of typical PCLBCL, leg type or RA/MTX-associated lymphoma.
authors.affiliation: Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horiike
authors.forename: Saori
authors.initials: S
authors.lastname: Maekawa
authors.forename: Taro
authors.initials: T
authors.lastname: Isohisa
authors.forename: Natsumi
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Chinen
authors.forename: Ryuko
authors.initials: R
authors.lastname: Nakayama
authors.forename: Miki
authors.initials: M
authors.lastname: Kiyota
authors.forename: Hisao
authors.initials: H
authors.lastname: Nagoshi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Mizutani
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimura
authors.forename: Mio
authors.initials: M
authors.lastname: Sugitani
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nakai
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D001402:B-Lymphocytes; D006801:Humans; D007866:Leg / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D008727:Methotrexate