title: Protective effects of hesperidin on concanavalin A-induced hepatic injury in mice.
abstract: Hesperidin (HDN) is a citrus bioflavonoid, which widely exists in many plants. Previous researches have proved that HDN has several functions such as anti-oxidant, anti-tumor, anti-inflammatory, immune regulation and so on. In the present study, we explored the protective effects of HDN on concanavalin A (Con A)-induced hepatic injury. Acute hepatic injury model was established successfully by intravenous administration of Con A (15 mg/kg) in male C57BL/6 mice, and HDN was pretreated for 10 days before Con A challenge. It was found that the hepatic injury was notably improved in HDN pretreated mice. Furthermore, hepatic oxidative stress and the production of proinflammatory cytokines including TNF-α and IFN-γ were decreased by HDN pretreatment. More importantly, compared with Con A-treated mice, the expression and releasing of HMGB1 and T-cell activation were markedly reduced in HDN pretreated mice. Thus, these results suggest that HDN protects mice from Con A-induced hepatic injury by suppressing hepatocyte oxidative stress, producing cytokines, expressing and releasing HMGB1 and activating T cells.
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Mao-Jian
authors.initials: MJ
authors.lastname: Chen
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Nie
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Huang
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Ting-Dong
authors.initials: TD
authors.lastname: Yuan
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China.
authors.forename: Ke-Gang
authors.initials: KG
authors.lastname: Shu
authors.affiliation: Clinical Laboratory Department, Jingzhou Center Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jingzhou 434020, PR China.
authors.forename: Chang-Fu
authors.initials: CF
authors.lastname: Wang
authors.affiliation: Department of Immunology, School of Medical, Yangtze University, Jingzhou 434023, PR China. Electronic address: gongquan1998@163.com.
authors.forename: Quan
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Gastroenterology, Jingzhou Center Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jingzhou 434020, PR China. Electronic address: jz-tsq@163.com.
authors.forename: Shao-Qian
authors.initials: SQ
authors.lastname: Tang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D003208:Concanavalin A / Q000009:adverse effects*; D024243:HMGB1 Protein / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006569:Hesperidin / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D024243:HMGB1 Protein; C582808:HMGB1 protein, mouse; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D007371:Interferon-gamma; D006569:Hesperidin
keywords: Concanavalin A; HMGB1; Hepatic injury; Hesperidin