title: C-reactive protein level in morbidly obese patients before and after bariatric surgery.
abstract: BACKGROUND
  Human obesity is associated with a proinflammatory state and an elevated level of mediators, such as C-reactive protein (CRP).
  
  
  OBJECTIVE
  To establish CRP levels as baseline preoperative values and then at 6 months after bariatric surgery, as well as to determine the changes in weight, body mass index (BMI), leukocytes, and glycemia.
  
  
  METHODS
  An observational, analytical, retrospective, longitudinal, and open study was conducted. Serum CRP values were measured in 36 adults presenting with morbid obesity, and their baseline relation to weight, BMI, leukocytes, and glycemia was determined; the relation to the same parameters was established again, 6 months after bariatric surgery.
  
  
  RESULTS
  The mean and standard deviation of preoperative and postoperative CRP (mg/L) was 1.15±0.86 and 0.34±0.28, respectively with p<0.0001; weight (kg) 112.10±22.91 and 84.82±17.11, p=0.0443; BMI (kg/m(2)) 42.48±5.97 and 32.2±4.79, p=0.0988; glucose (mg/dL) 100.58±17.82 and 87.11±8.49, p<0.0001, and leukocytes (× 10(3)/mm(3)) 8.62±1.69 and 6.99±1.56, p=0.3192. Baseline CRP only correlated with weight and BMI (p=0.047 and p=0.027 respectively) and there was no correlation between postoperative CRP and the evaluated parameters.
  
  
  CONCLUSIONS
  Preoperative CRP had a significant lineal relation to weight and body mass index. Patients who underwent bariatric surgery had a significant decrease in CRP, weight, and fasting glucose at 6 months after surgery.
authors.affiliation: División de Cirugía General y Endoscópica, Hospital General Dr. Manuel Gea González, México D.F., México.
authors.forename: M E
authors.initials: ME
authors.lastname: Rojano-Rodríguez
authors.affiliation: División de Cirugía General y Endoscópica, Hospital General Dr. Manuel Gea González, México D.F., México. Electronic address: carlosvalenzuelas@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Valenzuela-Salazar
authors.affiliation: División de Cirugía General y Endoscópica, Hospital General Dr. Manuel Gea González, México D.F., México.
authors.forename: L E
authors.initials: LE
authors.lastname: Cárdenas-Lailson
authors.affiliation: División de Cirugía General y Endoscópica, Hospital General Dr. Manuel Gea González, México D.F., México.
authors.forename: L S
authors.initials: LS
authors.lastname: Romero Loera
authors.affiliation: División de Cirugía General y Endoscópica, Hospital General Dr. Manuel Gea González, México D.F., México.
authors.forename: M
authors.initials: M
authors.lastname: Torres-Olalde
authors.affiliation: División de Cirugía General y Endoscópica, Hospital General Dr. Manuel Gea González, México D.F., México.
authors.forename: M
authors.initials: M
authors.lastname: Moreno-Portillo
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein
keywords: Bariatric surgery; C-reactive protein; Cirugía bariátrica; Obesidad; Obesity; Proteína C reactiva