title: [Renin-aldosterone and bone metabolism].
abstract: Among the components of the renin-angiotensin-aldosterone (RAAS) system, which controls blood pressure as well as fluid and electrolyte balance, renin, angiotensin II and its receptors AT1/2, and aldosterone and the mineralocorticoid receptor have been exploited as targets of drug development. Accumulating evidence suggests that the RAAS is linked, through a systemic/endocrine as well as a local loop, to inflammation, oxidative stress, cardiovascular and renal injury, and calcium and bone metabolism.
authors.affiliation: National Center for Geriatrics and Gerontology, Japan.
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics; D000450:Aldosterone / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000235:genetics; D055808:Drug Discovery; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics; D007249:Inflammation / Q000235:genetics; D058990:Molecular Targeted Therapy; D010024:Osteoporosis / Q000188:drug therapy / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D044139:Receptor, Angiotensin, Type 2 / Q000502:physiology; D018161:Receptors, Mineralocorticoid / Q000502:physiology; D012083:Renin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D018161:Receptors, Mineralocorticoid; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin; D002118:Calcium