title: Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools.
abstract: Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fibrosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fibrosis was made by abdominal palpation and the finding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fibrosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) findings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fibrosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BRAZIL.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Lambertucci
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D005243:Feces / Q000469:parasitology; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000175:diagnosis / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D012555:Schistosomiasis mansoni / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D013158:Splenic Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000469:parasitology; D014463:Ultrasonography
chemical_list: D015415:Biomarkers