title: Lobular neoplasia.
abstract: Lobular neoplasia (LN) is characterized by a dysfunctional E-cadherin-catenin axis, and loss of E-cadherin plays a causative role in the typical morphology of LN cells. LN is both a nonobligate precursor and a risk indicator of invasive breast cancer, and in particular, of invasive lobular carcinoma. Despite the evidence supporting the precursor role of LN, its impact on clinical management has been a matter of controversy, and conservative management remains the mainstay of treatment. In this article, an update is provided on the pathology and genetics of LN, and the management of these lesions in surgical practice is discussed.
authors.affiliation: Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA. Electronic address: kingt@mskcc.org.
authors.forename: Tari A
authors.initials: TA
authors.lastname: King
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
authors.forename: Jorge S
authors.initials: JS
authors.lastname: Reis-Filho
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D015820:Cadherins / Q000235:genetics; D002278:Carcinoma in Situ / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018275:Carcinoma, Lobular / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D006965:Hyperplasia; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D012306:Risk
chemical_list: D015820:Cadherins
keywords: Atypical lobular hyperplasia; Breast cancer risk; Chemoprevention; E-cadherin; Lobular carcinoma in situ; Lobular neoplasia