title: Graphene quantum dots-band-aids used for wound disinfection.
abstract: Herein, an antibacterial system combining the "safe" carbon nanomaterials, graphene quantum dots (GQDs), with a low level of H2O2 has been put forward. It has been found that the peroxidase-like activity of GQDs originates from their ability to catalyze the decomposition of H2O2, generating ·OH. Since the ·OH has a higher antibacterial activity, the conversion of H2O2 into ·OH improves the antibacterial performance of H2O2, which makes it possible to avoid the toxicity of H2O2 at high levels in wound disinfection. All the experiments in vitro display that this intrinsic activity exerts a high enhancement of antibacterial activity of H2O2, and the designed system possessed broad spectrum of antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. More importantly, to assess the antibacterial efficacy of the designed system in actual wound disinfection, the GQD-Band-Aids are prepared and show excellent antibacterial property with the assistance of H2O2 at low dose in vivo.
authors.affiliation: Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences , Changchun, Jilin 130022, China.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Sun
authors.forename: Nan
authors.initials: N
authors.lastname: Gao
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002384:Catalysis; D004203:Disinfection; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000378:metabolism; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017665:Hydroxyl Radical; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D045663:Quantum Dots; D013211:Staphylococcus aureus / Q000378:metabolism; D014945:Wound Healing; D014946:Wound Infection / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D017665:Hydroxyl Radical; D006108:Graphite; D006861:Hydrogen Peroxide