title: Autonomous motion and temperature-controlled drug delivery of Mg/Pt-poly(N-isopropylacrylamide) Janus micromotors driven by simulated body fluid and blood plasma.
abstract: In this work, we have demonstrated the autonomous motion of biologically-friendly Mg/Pt-Poly(N-isopropylacrylamide) (PNIPAM) Janus micromotors in simulated body fluids (SBF) or blood plasma without any other additives. The pit corrosion of chloride anions and the buffering effect of SBF or blood plasma in removing the Mg(OH)2 passivation layer play major roles for accelerating Mg-H2O reaction to produce hydrogen propulsion for the micromotors. Furthermore, the Mg/Pt-PNIPAM Janus micromotors can effectively uptake, transport, and temperature-control-release drug molecules by taking advantage of the partial surface-attached thermoresponsive PNIPAM hydrogel layers. The PNIPAM hydrogel layers on the micromotors can be easily replaced with other responsive polymers or antibodies by the surface modification strategy, suggesting that the as-proposed micromotors also hold a promising potential for separation and detection of heavy metal ions, toxicants, or proteins.
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology , Wuhan 430070, People's Republic of China.
authors.forename: Fangzhi
authors.initials: F
authors.lastname: Mou
authors.forename: Chuanrui
authors.initials: C
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhong
authors.forename: Yixia
authors.initials: Y
authors.lastname: Yin
authors.forename: Huiru
authors.initials: H
authors.lastname: Ma
authors.forename: Jianguo
authors.initials: J
authors.lastname: Guan
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000737:chemistry*; D010949:Plasma / Q000737:chemistry; D010984:Platinum / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D014867:Water; C052970:poly-N-isopropylacrylamide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010984:Platinum; D006859:Hydrogen; D008274:Magnesium