title: The potential of calcium silicate hydrate as a carrier of ibuprofen.
abstract: Calcium silicate nanostructured materials are promising drug carriers owing to their excellent biocompatibility, good bioactivity and high drug-loading capacity. In recent years, studies have been carried out on the synthesis of calcium silicate hydrate (CSH) nanostructured materials with desirable sizes and morphologies and their applications in drug delivery, where very interesting results and important insights have been documented. This editorial is not intended to offer a comprehensive review on the research on CSH nanostructured materials as drug carriers; rather, it presents representative examples: i) mesoporous microspheres; ii) ultrathin nanosheets; iii) iron oxide/CSH core/shell nanocomposites; and iv) CSH/block copolymer nanocomposites, and important results obtained in the study of CSH drug delivery systems for ibuprofen (IBU) as a model drug. These results show that the nanostructured CSH materials with specially designed architectures as IBU carriers have ultrahigh drug-loading capacity and sustainable drug release properties; thus, they are promising drug carriers for IBU. In addition, a new drug release kinetics has been found in the nanostructured CSH drug delivery systems. Most recently, new insight has been gained by tracking the behavior of these drug delivery systems on the molecular level using synchrotron-based X-ray spectroscopy.
authors.affiliation: Shanghai Institute of Ceramics, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Chinese Academy of Sciences , Shanghai 200050 , PR China +0086 21 52412616 ; +0086 21 52413122 ; y.j.zhu@mail.sic.ac.cn.
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Tsun-Kong
authors.initials: TK
authors.lastname: Sham
mesh_terms: D017610:Calcium Compounds / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D007052:Ibuprofen / Q000008:administration & dosage*; D008863:Microspheres; D049329:Nanostructures; D017640:Silicates / Q000737:chemistry*; D012824:Silicic Acid / Q000737:chemistry
chemical_list: D017610:Calcium Compounds; D004337:Drug Carriers; D005290:Ferric Compounds; D017640:Silicates; D012824:Silicic Acid; C000499:ferric oxide; C031293:calcium silicate; D007052:Ibuprofen
keywords: calcium silicate; drug delivery; drug release kinetics; ibuprofen; nanostructured materials; synchrotron spectroscopy