title: [Evaluations of seven different clinical staging systems for Chinese patients with hepatocellular carcinoma undergoing curative resection].
abstract: OBJECTIVE
  To compare the performance of 7 prognostic staging systems in predicting the survival of surgical patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  A total of 908 surgical HCC patients were recruited from January, 1999 to December, 2010 at our hospital. They were assigned retrospectively into different stages according to the classification criteria of 7 different staging systems. That is, Tumor-Node-Metastasis classification system (TNM7th), Barcelona Clinic Liver Cancer staging system (BCLC), Tokyo score, Japan Integrated Staging score (JIS), model for the Chinese University Prognostic Index grade (CUPI), Cancer of the Liver Italian Program score (CLIP) and Okuda staging. Kaplan-Meier survival estimations were performed and P values assessed with Log-rank test.
  
  
  RESULTS
  Significant survival difference was found across all groups of these staging systems(P < 0.05) except for comparison between TNM7th Stage IV versus III (P = 0.538), Tokyo score 4 versus 3 (P = 0.290) and 1 versus 0(P = 0.398), CLIP score 4 versus 3 (P = 0.073) and 3 versus 2 (P = 0.805) and Okuda stage II versus stage I (P = 0.872). For neutralizing potential bias in comparing prognostic scores with different numbers of stages, Akaike information criterion (AIC) was calculated by the results of Cox's regression. Therefore TNM7th had the lowest AIC result (AIC = 3 719.39).
  
  
  CONCLUSIONS
  TNM7th staging system is a better staging model for HCC of Chinese population among seven currently applied staging systems.
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yan
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China. Email: blizzardyt@163.com.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Cai
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies