title: Revisiting the role of first trimester homocysteine as an index of maternal and fetal outcome.
abstract: AIM. To revisit the role of first trimester homocysteine levels with the maternal and fetal outcome. METHODS. This was a cohort study comprising 100 antenatal women between 8 and 12 weeks of gestation. Serum homocysteine levels were checked after overnight fasting. RESULTS. There were significantly elevated homocysteine levels among women with prior history of hypertensive disorders of pregnancy and prior second or third trimester pregnancy losses. There was no significant difference in homocysteine levels among women with previous gestational diabetes mellitus, preterm deliveries, or fetal malformations. Homocysteine levels were significantly elevated in those who developed hypertensive disorder of pregnancy, oligohydramnios, and meconium stained amniotic fluid, had a pregnancy loss, or delivered a low birth weight baby. There was no significant difference in homocysteine levels for those who developed gestational diabetes mellitus. CONCLUSIONS. Increased first trimester serum homocysteine is associated with history of pregnancy losses, hypertensive disorders of pregnancy, and preterm birth. This is also associated with hypertensive disorders of pregnancy, pregnancy loss, oligohydramnios, meconium stained amniotic fluid, and low birth weight in the current pregnancy. This trial is registered with ClinicalTrials.gov CTRI/2013/02/003441.
authors.affiliation: Department of Reproductive Medicine, Christian Medical College, Vellore 632004, India.
authors.forename: Mariano
authors.identifier: 0000-0002-7859-7404
authors.initials: M
authors.lastname: Mascarenhas
authors.affiliation: Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605005, India.
authors.forename: Syed
authors.initials: S
authors.lastname: Habeebullah
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605005, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Sridhar
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood*; D000328:Adult; D000653:Amniotic Fluid; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D007230:Infant, Low Birth Weight; D008470:Meconium; D016104:Oligohydramnios / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D006710:Homocysteine