title: The predictor analysis of response to routine treatment in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
abstract: OBJECTIVE
  This study tried to test predictors of response to routine treatment in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH).
  
  
  METHODS
  Subjects were evaluated at baseline and at week 12 following routine treatment for LUTS/BPH using the Korean version of the International Prostate Symptom Score (IPSS) to measure the severity of LUTS/BPH. Demographics and various clinical variables were analyzed by regression analysis.
  
  
  RESULTS
  Ninety three patients received routine treatment for LUTS/BPH for 12 weeks in a naturalistic treatment setting. None of demographics and clinical variables was different between responders and non-responders. According to multivariate regression analysis, the presence of anxiety (OR=0.203), lower improvement in the GAD-7 total score (OR=0.755) and lower improvement in the PHQ-15 total score (OR=0.811) were independent predictors of treatment response after 12 weeks routine treatment.
  
  
  CONCLUSIONS
  We found the positive association of improvement in anxiety and somatization with treatment response, while presence of anxiety was negatively associated with treatment response, in patients with LUTS/BPH. However, additional studies with adequate power and improved designs are necessary to support the present findings.
authors.affiliation: Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea.
authors.forename: Yoo Hyun
authors.initials: YH
authors.lastname: Um
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, South Korea.
authors.forename: Jun Sung
authors.initials: JS
authors.lastname: Koh
authors.affiliation: Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, South Korea.
authors.forename: Hyo Jung
authors.initials: HJ
authors.lastname: Ko
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, South Korea.
authors.forename: Kang Joon
authors.initials: KJ
authors.lastname: Cho
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, South Korea.
authors.forename: Joon Chul
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea.
authors.forename: Soo-Jung
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea.
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
mesh_terms: D000368:Aged; D001007:Anxiety / Q000209:etiology; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D012107:Research Design; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000209:etiology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome