title: Extremely fast gas/liquid reactions in flow microreactors: carboxylation of short-lived organolithiums.
abstract: Carboxylation of short-lived organolithiums bearing electrophilic functional groups such as nitro, cyano, and alkoxycarbonyl groups with CO2 to give carboxylic acids and active esters was accomplished in a flow microreactor system. The successful reactions indicate that gas/liquid mass transfer and the subsequent chemical reaction with CO2 are extremely fast.
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yoshida
keywords: carboxylation; flow chemistry; lithiation; mass transfer; microreactors