title: Quantification of myocardial salvage by myocardial perfusion SPECT and cardiac magnetic resonance--reference standards for ECG development.
abstract: In order to determine the cardioprotective efficacy of acute reperfusion therapy, assessed as myocardial salvage, in patients with acute coronary occlusion, the final myocardial infarct (MI) size needs to be related to the amount of ischemic myocardium during coronary occlusion, referred to as the myocardium at risk (MaR). There are currently several imaging approaches available for quantification of both MI size and MaR in vivo of which some have been validated both in pre-clinical and clinical settings. These methods often involve the use of either myocardial perfusion SPECT or cardiac magnetic resonance (CMR). These imaging methods could potentially be used to further develop and validate ECG methods for determination of MI size and MaR. Therefore, the aim of the present review is to give an overview of myocardial perfusion SPECT and CMR methods available for assessment of myocardial salvage by determination of MI size and MaR.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Lund, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Engblom
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Lund, Sweden.
authors.forename: Anthony H
authors.initials: AH
authors.lastname: Aletras
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Lund, Sweden.
authors.forename: Einar
authors.initials: E
authors.lastname: Heiberg
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Lund, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Arheden
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Lund, Sweden. Electronic address: marcus.carlsson@med.lu.se.
authors.forename: Marcus
authors.initials: M
authors.lastname: Carlsson
mesh_terms: D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D055414:Myocardial Perfusion Imaging / Q000592:standards*; D011379:Prognosis; D012016:Reference Values; D015203:Reproducibility of Results; D016879:Salvage Therapy / Q000379:methods / Q000592:standards; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000592:standards*; D016896:Treatment Outcome
keywords: Cardiac magnetic resonance; Myocardial infarction; Myocardial perfusion SPECT; Myocardial salvage; Myocardium at risk