title: Effects of peptidic growth hormone secretagogue receptor (GHS-R) antagonist [D-Lys3] on some of serum hormonal and biochemical parameters in Wistar rat model.
abstract: OBJECTIVE
  The present study investigated the effects of different dosages of a GHS-R antagonist [D-Lys3] on some serum hormonal (cortisol, T3 and T4) and biochemical parameters in a rat.
  
  
  METHODS
  Thirty-six 60-day-old male rats were assigned to four treatments. [D-Lys3]-GHRP-6 solutions were infused via intraperitoneal injections. Blood was collected and analyzed.
  
  
  RESULTS
  The large dosages of a GHS-R antagonist (200 ng/kg BW) caused increases in cortisol, whereas no significant changes occurred when low dosages were injected. There were no significant changes in T3 and T4 following the administration of the GHS-R antagonist, but a considerable increase was observed in blood glucose levels of the groups (G50, G100, and G200 ng/kg BW). There was a significant increase in total protein when the greatest dose was administrated (G200 ng/kg BW). However, total cholesterol, triglycerides, and albumin showed no significant changes.
  
  
  CONCLUSIONS
  Exogenous GHS-R antagonist can cause an increase in glucose and moderate increases in cortisol and total protein, yet it has no significant effect on T3 and T4 levels or on the concentrations of serum lipids. The effect of GHS-R antagonist is not completely adverse to the effects of ghrelin. Further molecular studies are necessary to identify the physiological effects of the peptidic GHS-R antagonist.
authors.affiliation: Department of Animal Science, Shabestar Branch, Islamic Azad University, Shabestar, Iran.
authors.forename: Habib Aghdam
authors.initials: HA
authors.lastname: Shahryar
authors.affiliation: Ilkhchi Branch, Islamic Azad University, Ilkhchi, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Lotfi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D006854:Hydrocortisone / Q000097:blood*; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage*; D011897:Random Allocation; D017208:Rats, Wistar; D054440:Receptors, Ghrelin / Q000037:antagonists & inhibitors*; D012709:Serum Albumin / Q000032:analysis; D013974:Thyroxine / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; C520836:GHRP-6, Lys(3)-; D009842:Oligopeptides; D054440:Receptors, Ghrelin; D012709:Serum Albumin; D014280:Triglycerides; D014284:Triiodothyronine; D013974:Thyroxine; D006854:Hydrocortisone