title: Performance of a ⁶²Zn/⁶²Cu microgenerator in kit-based synthesis and delivery of [⁶²Cu]Cu-ETS for PET perfusion imaging.
abstract: The performance of a commercially produced (62)Zn/(62)Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [(62)Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23 GBq (62)Zn at 9:00 AM on the day of clinical use, a total of 45 patient doses of [(62)Cu]Cu-ETS (672±172 MBq) were delivered without difficulty. (62)Cu elution yields were high (approximately 90%), accompanied by extremely low (62)Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The (62)Zn/(62)Cu microgenerator was a dependable source of short-lived positron-emitting (62)Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [(62)Cu]Cu-ETS for PET perfusion imaging.
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Yen
authors.initials: Y
authors.lastname: Ng
authors.affiliation: Proportional Technologies, Inc. (PTI), Houston, TX, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Lacy
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Fletcher
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: magreen@iu.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Green
mesh_terms: D003301:Copper Radioisotopes / Q000737:chemistry*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D055420:Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D011876:Radionuclide Generators / Q000295:instrumentation*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013882:Thiosemicarbazones / Q000138:chemical synthesis*; D015037:Zinc Radioisotopes / Q000737:chemistry*
chemical_list: D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; D015037:Zinc Radioisotopes; C530436:ethylglyoxal bis(thiosemicarbazonato)copper(II)
keywords: (62)Zn/(62)Cu generator; PET radiopharmaceuticals; Tumor perfusion; [(62)Cu]Cu–ETS (copper(II) ethylglyoxal bis(thiosemicarbazone))