title: [Diagnosis of paraneoplastic polyneuropathy in patients with breast cancer and small cell lung cancer].
abstract: OBJECTIVE
  To study possibilities of immunological and electrophysiological methods for the diagnosis of paraneoplastic polyneuropathy in cancer.
  
  
  METHODS
  We studied 88 cancer patients using electromyography and immunological assay (serum neuronal antibodies).
  
  
  RESULTS
  A symmetrical, distal, sensory-motor, axonal-demyelinating form of polyneuropathy can develop in breast cancer and small cell lung cancer. Onconeural antibodies were detected in the serum of more than half of study participants as well as in some healthy donors. Symptoms of polyneuropathy appeared earlier than the diagnosed tumor.
  
  
  CONCLUSIONS
  The diagnostic value of the methods used for the early diagnosis of breast cancer and small cell lung cancer is emphasized.
authors.forename: E S
authors.initials: ES
authors.lastname: Koroleva
authors.forename: I S
authors.initials: IS
authors.lastname: Losenkov
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
authors.forename: V E
authors.initials: VE
authors.lastname: Goldberg
authors.forename: N S
authors.initials: NS
authors.lastname: Novikova
mesh_terms: D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology*; D020364:Paraneoplastic Polyneuropathy / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D055752:Small Cell Lung Carcinoma / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D000912:Antibodies, Neoplasm; D001323:Autoantibodies