title: BRAF V600E-mutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib.
abstract: Somatic BRAF mutations have been reported in 1-4% of non-small cell lung cancer (NSCLC), primarily in adenocarcinomas with the BRAF (V600E) mutation in about 50% of the cases. The role of BRAF mutation in NSCLC and the treatment for tumors with such mutations is still evolving. Our patient had metastatic NSCLC with metastases to her brain. Due to the BRAF (V600E) mutation in her tumor and her poor functional status, we offered her off-label treatment with vemurafenib, a BRAF inhibitor approved for use in metastatic melanoma. Our patient's visceral disease improved supporting vemurafenib's efficacy in the treatment of metastatic BRAF-mutated NSCLC. The regression of intracranial disease indicated vemurafenib was able to cross the blood-brain barrier and was efficacious in treating brain metastases in this patient with lung cancer.
authors.affiliation: Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Dallas, TX 75246, United States.
authors.forename: Sara D
authors.initials: SD
authors.lastname: Robinson
authors.affiliation: Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Dallas, TX 75246, United States; Texas Oncology, 3410 Worth Street, Dallas, TX 75246, United States.
authors.forename: Joyce A
authors.initials: JA
authors.lastname: O'Shaughnessy
authors.affiliation: Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Dallas, TX 75246, United States; Texas Oncology, 3410 Worth Street, Dallas, TX 75246, United States.
authors.forename: C Lance
authors.initials: CL
authors.lastname: Cowey
authors.affiliation: Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Dallas, TX 75246, United States; Texas Oncology, 3410 Worth Street, Dallas, TX 75246, United States. Electronic address: Kartik.Konduri@USOncology.com.
authors.forename: Kartik
authors.initials: K
authors.lastname: Konduri
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D013449:Sulfonamides / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D047428:Protein Kinase Inhibitors; D013449:Sulfonamides; D000077484:Vemurafenib; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF mutation; Brain metastasis; Lung adenocarcinoma; Non-small cell lung cancer; Targeted therapy; Vemurafenib