title: Comparison of nanocrystalline hydroxyapatite and synthetic resorbable hydroxyapatite graft in the treatment of intrabony defects: A clinical and radiographic study.
abstract: BACKGROUND
  The aim of this study is to compare, clinically and radiographically, the effectiveness of nanocrystalline hydroxyapatite (NHA) and synthetic resorbable hydroxyapatite (HA) in the treatment of intrabony defects.
  
  
  METHODS
  Ten subjects with bilateral defects, with probing depth (PD) 6-9 mm and radiographic evidence of an intraosseous component ≥4 mm participated in the present study. Subjects were allocated randomly to treatment with NHA (test group) or HA (control group). At baseline, 3 and 6 months after surgery, the following clinical parameters were recorded: Plaque index, gingival index, PD, relative attachment level (RAL), and radiographic reduction in intrabony defect.
  
  
  RESULTS
  At 6 months following therapy, the test group showed a reduction in mean PD from 6.4 ± 0.843 to 3.3 ± 0.8232 mm and a change in mean RAL from 12.9 ± 1.197 to 10.1 ± 0.7378 mm, whereas in the control group the mean PD decreased from 7.65 ± 1.8566 to 3.9 ± 1.1005 mm, and mean RAL decreased from 13.9 ± 0.9944 to 10.7 ± 0.6749 mm. On comparison of the mean difference in probing depth between the two groups after the unpaired t-test was applied at baseline, 3 months and 6 months, scores were found to be statistically non-significant (P > 0.01).
  
  
  CONCLUSIONS
  The results of the present study indicate that both NHA and conventional HA led to the improvement of clinical and radiographic parameters over the course of the study. However, the test group did not show any significant improvement over the control group.
authors.affiliation: Department of Periodontics, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, Ghaziabad, Uttar Pradesh, India.
authors.forename: Mansi
authors.initials: M
authors.lastname: Bansal
authors.affiliation: Department of Periodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.
authors.forename: Mayur
authors.initials: M
authors.lastname: Kaushik
authors.affiliation: Department of Periodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.
authors.forename: Brig B P
authors.initials: BB
authors.lastname: Khattak
authors.affiliation: Department of Periodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.
authors.forename: Anamika
authors.initials: A
authors.lastname: Sharma
keywords: Chronic periodontitis; debridement; hydoxyapatite; nanocrystalline; regeneration