title: Unfiltered Administration of the YMRS and CDRS-R in a Clinical Sample of Children.
abstract: The objective of this study is to evaluate discriminative validity of the Young Mania Rating Scale (YMRS) and Children's Depression Rating Scale-Revised (CDRS-R) in a clinical sample of children when administered in an unfiltered manner (i.e., regardless of whether symptoms occur in a mood episode). The Kiddie Schedule for Affective Disorders and Schizophrenia is the gold standard for assessing psychiatric disorders in children and was used to make diagnoses in this study. Using a sample of 707 treatment-seeking youth (ages 6-12 years, Mage = 9.7 years, 67.6% male), receiver operating curve analyses were performed and diagnostic likelihood ratios (DLRs) were calculated to evaluate the ability to change the odds and differentiate bipolar disorder from other disorders (using the YMRS) and depression from other disorders (using the CDRS-R). Using unfiltered administration, the YMRS achieved good discriminative validity when classifying bipolar disorder compared to other disorders (Area Under the Curve [AUC] = .86) and increased odds of a bipolar diagnosis given a score in the highest quintile (DLR = 6.12). Using unfiltered administration, the CDRS-R achieved moderate to good discriminative validity in classifying depressive disorders (DD) compared to other disorders (AUCBD in comparison = .78; AUCBD not in comparison = .84) and slightly increased odds of DD given a score in the highest quintile (DLRBD in comparison = 3.12; DLRBD not in comparison = 5.08). The YMRS and CDRS-R have moderate to good discriminative validity when administered in an unfiltered way in a sample of treatment seeking youth.
authors.affiliation: a Department of Psychology , The Ohio State University.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Yee
authors.affiliation: b Department of Psychiatry , The Ohio State University.
authors.forename: Guillermo Perez
authors.initials: GP
authors.lastname: Algorta
authors.affiliation: c Departments of Psychology and Psychiatry , University of North Carolina at Chapel Hill.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Youngstrom
authors.affiliation: d Department of Psychiatry , John Hopkins University.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Findling
authors.affiliation: e Department of Psychiatry , University of Pittsburgh.
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.affiliation: f Departments of Psychiatry, Psychology and Nutrition , The Ohio State University.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Fristad
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D002648:Child; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008137:Longitudinal Studies; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis* / Q000523:psychology; D010552:Personality Assessment / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000706:statistics & numerical data