title: [Outcomes after surgery for refractory constipation patients complicated with megacolon].
abstract: OBJECTIVE
  To explore the efficacy of different procedures for refractory constipation complicated with megacolon.
  
  
  METHODS
  Clinical data of 112 patients of refractory constipation complicated with megacolon undergoing surgery in our institute from June 2007 to January 2013 were retrospectively analyzed. Of these 112 patients, the duration of constipation ranged from 4 to 22 years. Seventy-four patients had previous abdominal operations. Surgical procedures: (1)Jinling procedure (subtotal colectomy plus ascending colorectal posterior wall side-to-side anastomosis, n=81), including 24 laparoscopy-assisted procedures, 18 terminal ileostomies. (2)total colectomy plus ileorectal side-to-side anastomosis(n=18). (3)total colectomy plus end ileostomy, and ileorectal posterior wall side-to-side anastomosis 6 months later(n=13). The end ileostomy was reversed 6 months after operation.
  
  
  RESULTS
  The successful rate was 100%, and no surgery-related deaths were found. Postoperative complications included early diarrhea (90 cases, 80.4%), anal pain and incomplete evacuation (22 cases, 19.6%), urinary retention within 24-48 h after catheter removal (16 cases, 14.2%), anastomosis bleeding (9 cases, 8.0%), anastomosis leakage (6 cases, 5.4%), and intestinal obstruction (15 cases, 13.4%). Six patients with intestinal obstruction underwent adhesiolysis, and others were managed by conservative therapy. At the postoperative follow-up at 6 months, the Wexner constipation score was significantly reduced (5.8-8.3 vs. 21.4-28.7, P<0.01), and malnutrition improved as well.
  
  
  CONCLUSIONS
  Surgical intervention results in good efficacy for refractory constipation complicated with megacolon.
authors.affiliation: Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China. jiangjun6987@163.com.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Ding
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Feng
authors.forename: Anlong
authors.initials: A
authors.lastname: Yao
authors.forename: Jianlei
authors.initials: J
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D003082:Colectomy / Q000379:methods; D003248:Constipation / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D007081:Ileostomy; D008297:Male; D008531:Megacolon / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult