title: A CD30(-) Transformed Mycosis Fungoides Case Responding Very Well to Systemic Bexarotene and Methotrexate.
abstract: The course of mycosis fungoides (MF) is indolent except when transformation to a large T-cell lymphoma occurs. The diagnosis of transformed MF relies on the presence of more than 25% of large cells on biopsy of an MF lesion. Treatment of transformed MF is a major challenge as these patients have poor outcome. Here, we report a 61-year-old man presenting with tumoral ulcer on the plantar area of the foot who was diagnosed cutaneous CD30(-) large cell transformed MF and treated with systemic methotraxate and bexarotene therapy.
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ilkin
authors.initials: I
authors.lastname: Zindanci
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Kavala
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Turkoğlu
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Burce
authors.initials: B
authors.lastname: Can
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Ozturk
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Zemheri
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Akbulak
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Mansuroglu
authors.affiliation: Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey filizsvet@yahoo.com.
authors.forename: Filiz
authors.initials: F
authors.lastname: Topaloğlu Demir
keywords: CD30(−) transformed MF; methotraxe and bexarotene therapy; mycosis fungoides (MF); ulcer