title: Factors associated with poor outcomes in adults with newly diagnosed ulcerative colitis.
abstract: It is a challenge to accurately identify patients with early stage ulcerative colitis (UC) who are at highest risk for a poor outcome and therefore might require salvage therapy. Several epidemiologic and clinical studies have analyzed factors associated with poor prognosis and increased risk for colectomy. We review prognostic factors for adults with newly diagnosed UC and discuss which patients might benefit from rapid and progressive therapy. Patients with poor prognoses tend to be young nonsmokers with high levels of inflammatory biomarkers, low levels of hemoglobin, and extensive disease, based on colonoscopy. We examine these risk factors in 2 hypothetical patients who have been newly diagnosed with UC.
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: reinisw@mcmaster.ca.
authors.forename: Walter
authors.initials: W
authors.lastname: Reinisch
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Reinink
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Peter D R
authors.initials: PD
authors.lastname: Higgins
mesh_terms: D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055502:Secondary Prevention; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007155:Immunologic Factors
keywords: IBD; Prognosis; TNF Inhibitor; Treatment; Tumor Necrosis Factor