title: [Regadenoson as a new stress agent in myocardial perfusion imaging. Initial experience in The Netherlands].
abstract: OBJECTIVE
  Regadenoson is a recently approved selective adenosine-2A receptor agonist to induce pharmacological stress in myocardial perfusion imaging (MPI) procedures using a single bolus injection.
  
  
  METHODS
  We included 123 patients referred for MPI because of suspected coronary arterial disease (CAD). Of these, 66 patients underwent a regadenoson stress test and 57 patients underwent an adenosine stress test preceding standard myocardial SPECT imaging. Technicians, physicians and patients were asked to report their experience using questionnaires.
  
  
  RESULTS
  As compared to adenosine, regadenoson did not produce any atrio-ventricular block (0 vs. 10% with adenosine), but did produce minor tachycardia and minimal blood pressure changes while all other side effects were milder and shorter. There were fewer patients with severe complaints after taking regadenoson than adenosine (17% vs. 32%, respectively, p<0.01). The most frequent complaint reported was dyspnea, followed by flushing and chest pain. However, when they did occur, they usually disappeared rapidly. The overall symptom score, including severity and duration of side effects, was significantly lower after regadenoson than after adenosine (6.7±6.3 vs. 10.0±7.9, respectively; p<0.01.) SPECT imaging results were similar. The regadenoson procedure was faster and more practical.
  
  
  CONCLUSIONS
  Regadenoson, the new selective adenosine-2A receptor agonist, is a stress agent for MPI with a patient- and department friendly profile.
authors.affiliation: Departamento de Medicina Nuclear, Hospital Isala, Zwolle, Holanda. Electronic address: p.l.jager@isala.nl.
authors.forename: P L
authors.initials: PL
authors.lastname: Jager
authors.affiliation: Departamento de Medicina Nuclear, Hospital Isala, Zwolle, Holanda.
authors.forename: M
authors.initials: M
authors.lastname: Buiting
authors.affiliation: Departamento de Medicina Nuclear, Hospital Isala, Zwolle, Holanda; Departamento de Cardiología, Hospital Isala, Zwolle, Holanda.
authors.forename: M
authors.initials: M
authors.lastname: Mouden
authors.affiliation: Departamento de Medicina Nuclear, Hospital Isala, Zwolle, Holanda.
authors.forename: A H J
authors.initials: AH
authors.lastname: Oostdijk
authors.affiliation: Departamento de Cardiología, Hospital Isala, Zwolle, Holanda.
authors.forename: J
authors.initials: J
authors.lastname: Timmer
authors.affiliation: Departamento de Medicina Nuclear, Hospital Isala, Zwolle, Holanda.
authors.forename: S
authors.initials: S
authors.lastname: Knollema
mesh_terms: D000241:Adenosine / Q000009:adverse effects / Q000494:pharmacology; D058908:Adenosine A2 Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054537:Atrioventricular Block / Q000139:chemically induced; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004417:Dyspnea / Q000139:chemically induced; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005483:Flushing / Q000139:chemically induced; D006321:Heart / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009426:Netherlands; D011687:Purines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011795:Surveys and Questionnaires; D013610:Tachycardia / Q000139:chemically induced; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D058908:Adenosine A2 Receptor Agonists; D011687:Purines; D011720:Pyrazoles; C430916:regadenoson; D000241:Adenosine
keywords: Adenosina; Adenosine; Atrio-ventricular block; Bloqueo auriculo-ventricular; Imágenes SPECT; Myocardial perfusion imaging; Perfusión miocárdica; Regadenoson; Regadenosón; SPECT images