title: Cytotoxic polyacetylenes from the Red Sea sponge Siphonochalina siphonella.
abstract: Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11.7 microM, respectively.
authors.forename: Seif-Eldin N
authors.initials: SE
authors.lastname: Ayyad
authors.forename: Rihab
authors.initials: R
authors.lastname: Angawy
authors.forename: Waliled M
authors.initials: WM
authors.lastname: Alarif
authors.forename: Esraa A
authors.initials: EA
authors.lastname: Saqer
authors.forename: Farid A
authors.initials: FA
authors.lastname: Badria
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D053279:Polyynes / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D053279:Polyynes