title: Mesoporous magnetic gold "nanoclusters" as theranostic carrier for chemo-photothermal co-therapy of breast cancer.
abstract: Photothermal therapy (PTT) is proved to be an efficient manner for superficial tumor therapy in preclinical studying. The tumor suppression of chemotherapy can be enhanced by combining with PTT. In this study, we reported a mesoporous magnetic gold "nanoclusters" (MMGNCs) structure as theranostic carrier for chemo-photothermal co-therapy. MMGNCs were successfully prepared and they exhibited efficient photo-thermal effect for PTT. The mesoporous structure provided MMGNCs with high drug loading capacity. By in vitro cytotoxicity testing, we revealed that the combination of PTT and chemotherapy could cause more damage than chemotherapy or PTT did alone. By topically targeting mediated by the extra-magnetic field (MF), MMGNCs can be targeted to the tumor site efficiently. In vivo chemo-photothermal co-therapy of 4T1 breast cancer, under the combinational treatments of chemo-photothermal co-therapy and extra-MF targeting, the tumor growth has been efficiently inhibited, and the pulmonary and mediastinal metastasis have also been prevented. The survival of the cancer bearing mice was prolonged. The bio-imaging applications of this system and the mechanism of the metastasis prevention are ongoing.
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: JinRong
authors.initials: J
authors.lastname: Peng
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: TingTing
authors.initials: T
authors.lastname: Qi
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: JinFeng
authors.initials: J
authors.lastname: Liao
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: BingYang
authors.initials: B
authors.lastname: Chu
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: Ying
authors.initials: Y
authors.lastname: Qu
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: WenTing
authors.initials: W
authors.lastname: Li
authors.affiliation: 2. School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.affiliation: 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D000818:Animals; D005260:Female; D006046:Gold / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D058726:Nanoconjugates / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*
chemical_list: D058185:Magnetite Nanoparticles; D058726:Nanoconjugates; D006046:Gold
keywords: Co-therapy.; Multidrug Resistance; Multifunctional nanoparticles; Photothermal Therapy