title: Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer.
abstract: Aberrant expression of glycoconjugates occurs during malignant transformation of cancer cells. Overexpression of sialoglycoconjugates in particular may play an important role in the progression, i.e., invasion or metastasis, of cancer. Various types of sialoglycoconjugates have been investigated to clarify their biological significance and clinical utility in diagnosing and treating colorectal cancer. This review focuses specifically on expression of mucin (MUC) 1 and it suggests that MUC1 with the specific structure of a sialo-oligosaccharide has biological significance in determining the metastatic potential of colorectal cancer cells and clinicopathological utility in evaluating the effectiveness of treatments and the prognosis for patients with colorectal cancer. Further studies are expected to contribute to the expanded use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy.
authors.affiliation: Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Inagaki
authors.affiliation: Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Gao
authors.affiliation: Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Peipei
authors.initials: P
authors.lastname: Song
authors.affiliation: Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kokudo
authors.affiliation: Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Munehiro
authors.initials: M
authors.lastname: Nakata
authors.affiliation: Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism; D018395:CA-19-9 Antigen; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003952:Diagnostic Imaging; D015972:Gene Expression Regulation, Neoplastic; D006001:Glycoconjugates / Q000737:chemistry*; D006801:Humans; D018396:Mucin-1 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009844:Oligosaccharides / Q000378:metabolism; D011379:Prognosis; D012794:Sialic Acids; D000080506:Sialyl Lewis X Antigen
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D018395:CA-19-9 Antigen; D006001:Glycoconjugates; C060192:MUC1 protein, human; D018396:Mucin-1; D009844:Oligosaccharides; D012794:Sialic Acids; D000080506:Sialyl Lewis X Antigen; C055491:sialosyl-Tn antigen
keywords: Colorectal cancer; Invasion; Metastasis; Mucin 1; Sialic acid; Sialoglycoconjugates