title: In vitro larvicidal and antioxidant activity of dihydrophenanthroline-3-carbonitriles.
abstract: Many naturally occurring and synthetic compounds containing dihydrocyanopyridine and cyanopyran moiety show pharmacological properties. The aim of this study is to investigate the larvicidal and antioxidant potential of dihydrophenanthroline-3-carbonitrile derivatives 4a-f. A novel series of 2-amino-10-chloro-4,12-diphenyl-1,4,5,6-tetrahydrobenzo[j][1,7]phenanthroline-3-carbonitrile derivatives were synthesized by reacting different substituted acridine chalcones through Michel addition. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of FT-IR, 1H NMR, 13C NMR, and ESI Mass analysis data. All the synthesized compounds were evaluated for larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae. Furthermore, the antioxidant activity was studied by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. From the antioxidant assay, the compound 4c was reported with profound antioxidant potential.
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India.
authors.forename: A
authors.initials: A
authors.lastname: Bharathi
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India.
authors.forename: Selvaraj Mohana
authors.identifier: 0000-0002-1416-9654
authors.initials: SM
authors.lastname: Roopan
authors.affiliation: Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research, Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, Tamil Nadu 632 509, India.
authors.forename: Abdul Abdul
authors.initials: AA
authors.lastname: Rahuman
authors.affiliation: Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research, Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, Tamil Nadu 632 509, India.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Rajakumar
mesh_terms: D000166:Acridines / Q000737:chemistry; D000330:Aedes; D000818:Animals; D000962:Antimalarials / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D001681:Biological Assay; D047188:Chalcones / Q000737:chemistry; D003465:Culex; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009032:Mosquito Control; D009570:Nitriles / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000166:Acridines; D000962:Antimalarials; D000975:Antioxidants; D047188:Chalcones; D007306:Insecticides; D009570:Nitriles