title: Insights from the worm: the C. elegans model for innate immunity.
abstract: The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C. elegans recognizes and responds to viral, bacterial, and fungal infections. Components of the RNA interference machinery respond to viral infection, while highly conserved MAPK signaling pathways activate the innate immune response to bacterial infection. C. elegans has been particularly important for exploring the role of innate immunity in organismal stress resistance and the regulation of longevity. Also functions of neuronal sensing of infectious bacteria have recently been uncovered. Studies on nematode immunity can be instructive in exploring innate immune signaling in the absence of specialized immune cells and adaptive immunity.
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, and Systems Biology of Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Ermolaeva
authors.affiliation: Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, and Systems Biology of Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
authors.forename: Björn
authors.initials: B
authors.lastname: Schumacher
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D023421:Models, Animal; D012038:Regeneration
chemical_list: D029742:Caenorhabditis elegans Proteins
keywords: Ancestral immunity; C. elegans; Host–pathogen interaction; Innate immunity