title: Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease.
abstract: The oral lichenoid disease (OLD) includes different chronic inflammatory processes such as oral lichen planus (OLP) and oral lichenoid lesions (OLL), both entities with controversial diagnosis and malignant potential. Epidermal growth factor receptor (EFGR) is an important oral carcinogenesis biomarker and overexpressed in several oral potentially malignant disorders.
  
  
  OBJECTIVE
  To analyze the EGFR expression in the OLD to find differences between OLP and OLL, and to correlate it with the main clinical and pathological features.
  
  
  METHODS
  Forty-four OLD cases were studied and classified according to their clinical (Group C1: only papular lesions / Group C2: papular and other lesions) and histopathological features (Group HT: OLP-typical / Group HC: OLP-compatible) based in previous published criteria. Standard immunohistochemical identification of EGFR protein was performed. Comparative and descriptive statistical analyses were performed.
  
  
  RESULTS
  Thirty-five cases (79.5%) showed EGFR overexpression without significant differences between clinical and histopathological groups (p<0.05). Histological groups showed significant differences in the EGFR expression pattern (p=0.016). Conlusions: All OLD samples showed high EGFR expression. The type of clinical lesion was not related with EGFR expression; however, there are differences in the EGFR expression pattern between histological groups that may be related with a different biological profile and malignant risk.
authors.affiliation: Unidad de Medicina Bucal y de Patología Oral y Maxilofacial, Dpto. de Estomatología II, Universidad del País Vasco /EHU, Leioa 48940, Bizkaia, (Spain), josemanuel.aguirre@ehu.es.
authors.forename: Dionisio-Alejandro
authors.initials: DA
authors.lastname: Cortés-Ramírez
authors.forename: María-Jose
authors.initials: MJ
authors.lastname: Rodríguez-Tojo
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Coca-Meneses
authors.forename: Xabier
authors.initials: X
authors.lastname: Marichalar-Mendia
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: Aguirre-Urizar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000145:classification* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D066246:ErbB Receptors