title: The adsorption-desorption transition of double-stranded DNA interacting with an oppositely charged dendrimer induced by multivalent anions.
abstract: The adsorption-desorption transition of DNA in DNA-dendrimer solutions is observed when high-valence anions, such as hexavalent anions, are added to the DNA-dendrimer solutions. In the DNA-dendrimer solutions with low-valence anions, dendrimers bind tightly with the V-shaped double-stranded DNA. When high-valence anions, such as pentavalent or hexavalent anions, are added to the DNA-dendrimer solutions, the double-stranded DNA chains can be stretched straightly and the dendrimers are released from the double-stranded DNA chains. In fact, adding high-valence anions to the solutions can change the charge spatial distribution in the DNA-dendrimer solutions, and weaken the electrostatic interactions between the positively charged dendrimers and the oppositely charged DNA chains. Adsorption-desorption transition of DNA is induced by the overcharging of dendrimers. This investigation is capable of helping us understand how to control effectively the release of DNA in gene/drug delivery because an effective gene delivery for dendrimers includes non-covalent DNA-dendrimer binding and the effective release of DNA in gene therapy.
authors.affiliation: Department of Physics, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yangwei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Physics, Zhejiang University, Hangzhou 310027, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Civil Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Yaoyang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Physics, Zhejiang University, Hangzhou 310027, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Physics, Wenzhou University, Wenzhou 325035, China.
authors.forename: Linxi
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D000838:Anions / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D055672:Static Electricity
chemical_list: D000838:Anions; D050091:Dendrimers; D012996:Solutions; D004247:DNA