title: Mean platelet volume and ischemia modified albumin levels in cord blood of infants of diabetic mothers.
abstract: BACKGROUND
  Gestational diabetes mellitus (GDM) is a risk for the health of both the pregnant women and her infant. Its unfavorable effects start in utero and continue after birth. It is known that GDM increases oxidative stress and decreases antioxidant enzyme activities. In this study we aimed to investigate cord blood mean platelet volume (MPV) and ischemia-modified albumin (IMA) levels of infants of diabetic mothers (IDM).
  
  
  METHODS
  Twenty-nine pregnant women with GDM between 37 and 41 gestational weeks who gave birth by spontaneous vaginal delivery were enrolled as study participants together with 20 healthy pregnant women as a control group. Weight, length, and head circumference of babies were measured by the same standard tape immediately after birth. Five milliliters of umbilical venous blood were obtained to study MPV and IMA levels.
  
  
  RESULTS
  There was statistically significant difference in levels of MPV (p = 0.037) and IMA (p < 0.001) between groups. They increased in IDM compared with their healthy peers.
  
  
  CONCLUSIONS
  Evaluation of MPV and IMA together is useful for representing the potential oxidative stress of IDM.
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Pediatrics, Çanakkale, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Topaloğlu
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Pediatrics, Çanakkale, Turkey. Electronic address: sulesln@yahoo.com.
authors.forename: Şule
authors.initials: Ş
authors.lastname: Yıldırım
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Pediatrics, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tekin
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Pediatrics, Çanakkale, Turkey.
authors.forename: Nazan
authors.initials: N
authors.lastname: Kaymaz
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Biochemistry, Çanakkale, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Tütüncüler
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Pediatrics, Çanakkale, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Özdemir
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Obstetrics and Gynecology, Çanakkale, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Coşar
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D063847:Mean Platelet Volume; D018384:Oxidative Stress; D011247:Pregnancy; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: cord blood; gestational diabetes; ischemia modified albumin; mean platelet volume; oxidative stress