title: Prevalence, morbidity, and mortality patterns of typhoid ileal perforation as seen at the University of Nigeria Teaching Hospital Enugu Nigeria: an 8-year review.
abstract: BACKGROUND
  Some recent studies have reported a decrease in mortality from typhoid ileal perforation. The present report aims to determine the prevalence, morbidity, and mortality of this disease in patients mostly drawn from a rural area.
  
  
  METHODS
  This is a retrospective study of 50 patients treated between January 1999 and December 2007 at the University of Nigeria Teaching Hospital, Enugu, Nigeria. The variables studied included patient demographics, clinical features, intraoperative findings, complications, and mortality. Statistical analysis was done with SPSS version 13.
  
  
  RESULTS
  Of the 50 patients included in the study, 22 were males with the highest rate in patients aged 20 years and younger. Fever was the commonest symptom and at initial presentation, the mean pulse and respiratory rates were significantly higher in the patients who subsequently died than in those who survived (P < 0.05). All the perforations occurred in the ileum; 62 % of the patients had solitary perforations, 28 % had double perforations, and 10 % had three or more. Fifty-eight perforations were treated by simple closure in two layers, 4 patients had ileal resection and anastomosis, and 2 underwent right hemicolectomy. The mean interval between operation and death was 1.7 days. The overall mortality rate was 30 %, but among those with three or more perforations, mortality was 100 %.
  
  
  CONCLUSIONS
  Typhoid ileal perforation still carries a high mortality especially in rural areas. Those with tachycardia and tachypnea at presentation and those with three or more perforations are at a higher risk of dying from the disease.
authors.affiliation: Department of Surgery, University of Nigeria Teaching Hospital, Enugu, Nigeria, drkena_agu@yahoo.co.uk.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Agu
authors.forename: Martin
authors.initials: M
authors.lastname: Nzegwu
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Obi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005334:Fever / Q000382:microbiology; D006784:Hospitals, Teaching; D006801:Humans; D007077:Ileal Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D007416:Intestinal Perforation / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013534:Survival; D014435:Typhoid Fever / Q000150:complications*; D055815:Young Adult