title: Management of uveitis-related choroidal neovascularization: from the pathogenesis to the therapy.
abstract: Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. A review on the factors implicated so far in the pathogenesis of inflammatory choroidal neovascularization was performed. Also we reported the success rate of single studies concerning the therapies of choroidal neovascularization secondary to uveitis during the last decade: photodynamic therapy, intravitreal bevacizumab, and intravitreal ranibizumab, besides steroidal and immunosuppressive therapy. Hereby a standardization of the therapeutic approach is proposed.
authors.affiliation: Department of Ophthalmology, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: D'Ambrosio
authors.affiliation: Department of Ophthalmology, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Tortorella
authors.affiliation: Department of Ophthalmology, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Ludovico
authors.identifier: 0000-0002-1009-3613
authors.initials: L
authors.lastname: Iannetti