title: A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone.
abstract: An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55% yield of one structural isomer (trans-antiderivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.
authors.affiliation: Department of Pharmacy Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Myers
authors.affiliation: Department of Pharmacy Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Kramer
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Bornmann
authors.affiliation: Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kaseb
authors.affiliation: Department of General Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Peiying
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Pharmacy Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA ; Department of Thoracic Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Hai T
authors.initials: HT
authors.lastname: Tran
keywords: X-ray structure; dithymoquinone; photodimerization; thymoquinone