title: Profile of the use of disease modifying drugs in the Brazilian Registry of Spondyloarthritides.
abstract: BACKGROUND
  Few studies have evaluated the profile of use of disease modifying drugs (DMD) in Brazilian patients with spondyloarthritis (SpA).
  
  
  METHODS
  A common research protocol was applied prospectively in 1505 patients classified as SpA by criteria of the European Spondyloarthropathies Study Group (ESSG), followed at 29 referral centers in Rheumatology in Brazil. Demographic and clinical variables were obtained and evaluated, by analyzing their correlation with the use of DMDs methotrexate (MTX) and sulfasalazine (SSZ).
  
  
  RESULTS
  At least one DMD was used by 73.6% of patients: MTX by 29.2% and SSZ by 21.7%, while 22.7% used both drugs. The use of MTX was significantly associated with peripheral involvement, and SSZ was associated with axial involvement, and the two drugs were more administered, separately or in combination, in the mixed involvement (p < 0.001). The use of a DMD was significantly associated with Caucasian ethnicity (MTX , p = 0.014), inflammatory back pain (SSZ, p = 0.002) , buttock pain (SSZ, p = 0.030), neck pain (MTX, p = 0.042), arthritis of the lower limbs (MTX, p < 0.001), arthritis of the upper limbs (MTX, p < 0.001), enthesitis (p = 0.007), dactylitis (MTX, p < 0.001), inflammatory bowel disease (SSZ, p < 0.001) and nail involvement (MTX, p < 0.001).
  
  
  CONCLUSIONS
  The use of at least one DMD was reported by more than 70% of patients in a large cohort of Brazilian patients with SpA, with MTX use more associated with peripheral involvement and the use of SSZ more associated with axial involvement.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Kohem
authors.affiliation: Instituto Insper de Educação e Pesquisa, São Paulo, SP, Brasil.
authors.forename: Adriana B
authors.initials: AB
authors.lastname: Bortoluzzo
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Célio R
authors.initials: CR
authors.lastname: Gonçalves
authors.affiliation: Universidade de Brasília, Brasília, DF, Brasil.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Braga da Silva
authors.affiliation: Hospital Geral de Goiânia, Goiânia, GO, Brasil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Ximenes
authors.affiliation: Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors.forename: Manoel B
authors.initials: MB
authors.lastname: Bértolo
authors.affiliation: Universidade Federal do Amazonas, Manaus, AM, Brasil.
authors.forename: Sandra L E
authors.initials: SL
authors.lastname: Ribeiro
authors.affiliation: Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brasil.
authors.forename: Mauro
authors.initials: M
authors.lastname: Keiserman
authors.affiliation: Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brasil.
authors.forename: Rita
authors.initials: R
authors.lastname: Menin
authors.affiliation: Hospital Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Sueli
authors.initials: S
authors.lastname: Carneiro
authors.affiliation: Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: Valderílio F
authors.initials: VF
authors.lastname: Azevedo
authors.affiliation: Hospital Geral de Fortaleza, Fortaleza, CE, Brasil.
authors.forename: Walber P
authors.initials: WP
authors.lastname: Vieira
authors.affiliation: Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Elisa N
authors.initials: EN
authors.lastname: Albuquerque
authors.affiliation: Santa Casa do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Washington A
authors.initials: WA
authors.lastname: Bianchi
authors.affiliation: Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil.
authors.forename: Rubens
authors.initials: R
authors.lastname: Bonfiglioli
authors.affiliation: Santa Casa de São Paulo, São Paulo, SP, Brasil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Campanholo
authors.affiliation: Hospital de Base, Brasília, DF, Brasil.
authors.forename: Hellen M S
authors.initials: HM
authors.lastname: Carvalho
authors.affiliation: Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brasil.
authors.forename: Izaias Pereira
authors.initials: IP
authors.lastname: da Costa
authors.affiliation: Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Angela L B Pinto
authors.initials: AL
authors.lastname: Duarte
authors.affiliation: Faculdade de Medicina Souza Marques, Rio de Janeiro, RJ, Brasil.
authors.forename: Nocy H
authors.initials: NH
authors.lastname: Leite
authors.affiliation: Hospital do Servidor Público Estadual, São Paulo, SP, Brasil.
authors.forename: Sonia A L
authors.initials: SA
authors.lastname: Lima
authors.affiliation: Instituto de Ortopedia e Traumatologia, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Eduardo S
authors.initials: ES
authors.lastname: Meirelles
authors.affiliation: Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors.forename: Ivânio A
authors.initials: IA
authors.lastname: Pereira
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Pinheiro
authors.affiliation: Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.
authors.forename: Elizandra
authors.initials: E
authors.lastname: Polito
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Gustavo G
authors.initials: GG
authors.lastname: Resende
authors.affiliation: Universidade Federal do Ceará, Fortaleza, CE, Brasil.
authors.forename: Francisco Airton C
authors.initials: FA
authors.lastname: Rocha
authors.affiliation: Escola de Medicina e Saúde Pública, Salvador, BA, Brasil.
authors.forename: Mittermayer B
authors.initials: MB
authors.lastname: Santiago
authors.affiliation: Universidade Federal do Pará, Belém, PA, Brasil.
authors.forename: Maria de Fátima L C
authors.initials: Mde F
authors.lastname: Sauma
authors.affiliation: Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
authors.forename: Valéria
authors.initials: V
authors.lastname: Valim
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Percival D
authors.initials: PD
authors.lastname: Sampaio-Barros
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001938:Brazil; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D011446:Prospective Studies; D012042:Registries; D025241:Spondylarthritis / Q000188:drug therapy*; D012460:Sulfasalazine / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine; D008727:Methotrexate