title: Von hippel-lindau disease associated pulmonary carcinoid with cranial metastasis.
abstract: BACKGROUND
  Carcinoids have rarely been described in von Hippel-Lindau (VHL) disease.
  
  
  OBJECTIVE
  We describe the first reported case of a patient with VHL who developed a pulmonary carcinoid that subsequently metastasized to a pre-existent cranial hemangioblastoma.
  
  
  RESULTS
  Histological and immunohistochemical features of the metastatic lesion were similar to the primary carcinoid. Both lesions demonstrated heterozygous VHL gene deletions with fluorescence in situ hybridization analysis.
  
  
  CONCLUSIONS
  This case provides direct molecular genetic evidence of an association between VHL and carcinoids.
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (C.Z., A.I.Y., C.Y., C.L.N., P.C., J.D.H., Z.Z., K.A.Z.), and Laboratory of Pathology, National Cancer Institute (L.V., S.M., L.S., Z.A., S.D.P., A.G., M.M.Q.), National Institutes of Health, Bethesda, Maryland 20892; and Department of Orthopedics (C.Z.), Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Yang
authors.forename: Lucas
authors.initials: L
authors.lastname: Vasconcelos
authors.forename: Seog
authors.initials: S
authors.lastname: Moon
authors.forename: Chunzhang
authors.initials: C
authors.lastname: Yang
authors.forename: Cody L
authors.initials: CL
authors.lastname: Nesvick
authors.forename: Lola
authors.initials: L
authors.lastname: Saidkhodjaeva
authors.forename: Ziedulla
authors.initials: Z
authors.lastname: Abdullaev
authors.forename: Svetlana D
authors.initials: SD
authors.lastname: Pack
authors.forename: Arunima
authors.initials: A
authors.lastname: Ghosh
authors.forename: Prashant
authors.initials: P
authors.lastname: Chittiboina
authors.forename: John D
authors.initials: JD
authors.lastname: Heiss
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Zhuang
authors.forename: Martha M
authors.initials: MM
authors.lastname: Quezado
authors.forename: Kareem A
authors.initials: KA
authors.lastname: Zaghloul
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D018325:Hemangioblastoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000150:complications* / Q000175:diagnosis