title: Development of live attenuated influenza vaccines against pandemic influenza strains.
abstract: Avian and animal influenza viruses can sporadically transmit to humans, causing outbreaks of varying severity. In some cases, further human-to-human virus transmission does not occur, and the outbreak in humans is limited. In other cases, sustained human-to-human transmission occurs, resulting in worldwide influenza pandemics. Preparation for future pandemics is an important global public health goal. A key objective of preparedness is to gain an understanding of how to design, test, and manufacture effective vaccines that could be stockpiled for use in a pandemic. This review summarizes results of an ongoing collaboration to produce, characterize, and clinically test a library of live attenuated influenza vaccine strains (based on Ann Arbor attenuated Type A strain) containing protective antigens from influenza viruses considered to be of high pandemic potential.
authors.affiliation: AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA.
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Coelingh
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Luke
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.forename: Kawsar R
authors.initials: KR
authors.lastname: Talaat
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001717:Birds; D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology / Q000517:prevention & control; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D058873:Pandemics / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
keywords: LAIV; intranasal influenza vaccine; pandemic influenza vaccine