title: Bypassing AMPK phosphorylation.
abstract: AMP-activated protein kinase (AMPK) functions as a signaling hub to balance energy supply with demand. Phosphorylation of activation loop Thr172 has been considered as an essential step in AMPK activation. In this issue of Chemistry & Biology, Scott and colleagues show that the small molecule direct AMPK activator, A-769662, bypasses this phosphorylation event and acts synergistically with AMP on naive AMPK.
authors.affiliation: INSERM, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France. Electronic address: benoit.viollet@inserm.fr.
authors.forename: Benoit
authors.initials: B
authors.lastname: Viollet
authors.affiliation: INSERM, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Foretz
authors.affiliation: Laboratory of Fundamental and Applied Bioenergetics, University Grenoble Alpes, 38185 Grenoble, France; Inserm, U1055, 38041 Grenoble, France.
authors.forename: Uwe
authors.initials: U
authors.lastname: Schlattner
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D001713:Biphenyl Compounds; D011753:Pyrones / Q000494:pharmacology*; D015398:Signal Transduction; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D001713:Biphenyl Compounds; D011753:Pyrones; D013876:Thiophenes; D000249:Adenosine Monophosphate; D055372:AMP-Activated Protein Kinases; C512408:4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile