title: Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis.
abstract: Meta-analyses, broadly defined as the quantitative review and synthesis of the results of related but independent comparable studies, allow to know the state of the art of one considered topic. Since the amount of available bibliography has enhanced in almost all fields and, specifically, in biomedical research, its popularity has drastically increased during the last decades. In particular, different methodologies have been developed in order to perform meta-analytic studies of diagnostic tests for both fixed- and random-effects models. From a parametric point of view, these techniques often compute a bivariate estimation for the sensitivity and the specificity by using only one threshold per included study. Frequently, an overall receiver operating characteristic curve based on a bivariate normal distribution is also provided. In this work, the author deals with the problem of estimating an overall receiver operating characteristic curve from a fully non-parametric approach when the data come from a meta-analysis study i.e. only certain information about the diagnostic capacity is available. Both fixed- and random-effects models are considered. In addition, the proposed methodology lets to use the information of all cut-off points available (not only one of them) in the selected original studies. The performance of the method is explored through Monte Carlo simulations. The observed results suggest that the proposed estimator is better than the reference one when the reported information is related to a threshold based on the Youden index and when information for two or more points are provided. Real data illustrations are included.
authors.affiliation: Oficina de Investigación Biosanitaria de Asturies (OIB-FICYT) and Universidad de Oviedo, Oviedo, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Camblor
mesh_terms: D003955:Diagnostic Tests, Routine / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000032:analysis; D015201:Meta-Analysis as Topic; D009010:Monte Carlo Method; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000151:congenital / Q000175:diagnosis / Q000276:immunology; D018709:Statistics, Nonparametric
chemical_list: D015850:Interleukin-6
keywords: meta-analysis; random-effects; receiver operating characteristic curve; sensitivity; specificity