title: From gene action to reactive genomes.
abstract: Poised at a critical turning point in the history of genetics, recent work (e.g. in genomics, epigenetics, genomic plasticity) obliges us to critically reexamine many of our most basic concepts. For example, I argue that genomic research supports a radical transformation in our understanding of the genome--a shift from an earlier conception of that entity as an effectively static collection of active genes to that of a dynamic and reactive system dedicated to the context specific regulation of protein-coding sequences.
authors.affiliation: MIT, Program in Science, Technology, and Society, Cambridge, MA 02139, USA efkeller@mit.edu.
authors.forename: Evelyn Fox
authors.initials: EF
authors.lastname: Keller
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000502:physiology*; D016678:Genome / Q000502:physiology*; D023281:Genomics