title: Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database.
abstract: OBJECTIVE
  To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).
  
  
  METHODS
  We used Cox regression to analyze data of a cohort of Asian children.
  
  
  RESULTS
  A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < -3 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.
  
  
  CONCLUSIONS
  Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.
authors.affiliation: *The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; †TREAT Asia/amfAR-The Foundation for AIDS Research, Bangkok, Thailand; ‡Programs for HIV Prevention and Treatment, Institut de Recherche pour le Développement, France, and Chiang Mai University, Chiang Mai, Thailand; §YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ‖Infectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam; ¶Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; #Pediatric Department, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; **Pediatric Department , Khon Kaen University, Khon Kaen, Thailand; ††Pediatric Department , Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡‡Infectious Disease Department, Children's Hospital 1, Ho Chi Minh City, Vietnam; §§Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; ‖‖TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia; ¶¶Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ##HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††Pediatric Allergy-Immunology Division, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; ‡‡‡Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; §§§Department of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia; ‖‖‖Department of Pediatrics, Penang Hospital, Penang, Malaysia; and ¶¶¶Allergy-Immunology Division, Sanglah Hospital, Udayana University, Bali, Indonesia.
authors.forename: Azar
authors.initials: A
authors.lastname: Kariminia
authors.forename: Nicolas
authors.initials: N
authors.lastname: Durier
authors.forename: Gonzague
authors.initials: G
authors.lastname: Jourdain
authors.forename: Suneeta
authors.initials: S
authors.lastname: Saghayam
authors.forename: Chau V
authors.initials: CV
authors.lastname: Do
authors.forename: Lam Van
authors.initials: LV
authors.lastname: Nguyen
authors.forename: Rawiwan
authors.initials: R
authors.lastname: Hansudewechakul
authors.forename: Pagakrong
authors.initials: P
authors.lastname: Lumbiganon
authors.forename: Kulkanya
authors.initials: K
authors.lastname: Chokephaibulkit
authors.forename: Khanh Huu
authors.initials: KH
authors.lastname: Truong
authors.forename: Virat
authors.initials: V
authors.lastname: Sirisanthana
authors.forename: Vibol
authors.initials: V
authors.lastname: Ung
authors.forename: Saphonn
authors.initials: S
authors.lastname: Vonthanak
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.forename: Nik Khairulddin
authors.initials: NK
authors.lastname: Nik Yusoff
authors.forename: Nia
authors.initials: N
authors.lastname: Kurniati
authors.forename: Kamarul
authors.initials: K
authors.lastname: Azahar Razali
authors.forename: Moy Siew
authors.initials: MS
authors.lastname: Fong
authors.forename: Revathy
authors.initials: R
authors.lastname: Nallusamy
authors.forename: Dewi Kumara
authors.initials: DK
authors.lastname: Wati
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001208:Asia; D001827:Body Height / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D016016:Proportional Hazards Models; D017211:Treatment Failure; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents