title: Fatal carboplatin-induced immune hemolytic anemia in a child with a brain tumor.
abstract: Drug-induced immune hemolytic anemia (DIIHA) is an uncommon side effect of pharmacologic intervention. A rare mediator of DIIHA, carboplatin is an agent used to treat many pediatric cancers. We describe here, the first case of fatal carboplatin induced DIIHA in a pediatric patient and a brief review of the literature. Our patient developed acute onset of multi-organ failure with evidence of complement activation, secondary to a drug induced red cell antibody. Early recognition of the systemic insult associated with carboplatin induced hemolytic anemia may allow for future affected patients to receive plasmapheresis, a potentially effective therapy.
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Haley
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, Wake Forest Baptist Health, Medical Center Blvd, Winston-Salem, NC, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Russell
authors.affiliation: Departments of Pathology, Medicine and Pediatrics, Oregon Health and Science University, Portland, OR, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Boshkov
authors.affiliation: American Red Cross Blood Services, Pomona, CA, USA.
authors.forename: Regina M
authors.initials: RM
authors.lastname: Leger
authors.affiliation: American Red Cross Blood Services, Pomona, CA, USA.
authors.forename: George
authors.initials: G
authors.lastname: Garratty
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Recht
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
authors.forename: Kellie J
authors.initials: KJ
authors.lastname: Nazemi
keywords: carboplatin; complement fixation; drug-induced hemolysis; glioma; hemolytic anemia