title: The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments.
abstract: Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.
authors.affiliation: Department of Chemistry, Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: C Tony
authors.initials: CT
authors.lastname: Liu
authors.affiliation: Department of Chemistry & Biochemistry, University of the Sciences, 600 S. 43rd Street, Philadelphia, PA 19104-4495, United States. Electronic address: j.tomsho@usciences.edu.
authors.forename: John W
authors.initials: JW
authors.lastname: Tomsho
authors.affiliation: Department of Chemistry, Pennsylvania State University, University Park, PA 16802, United States. Electronic address: sjb1@psu.edu.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Benkovic
mesh_terms: D001709:Biotechnology; D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007935:Leucine-tRNA Ligase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001896:Boron Compounds; D004791:Enzyme Inhibitors; D007935:Leucine-tRNA Ligase
keywords: Benzoboroxole; Benzoxaborole; Boronic acid; Oxaborole; Sulfenic acid