title: Galectins CLIC cargo inside.
abstract: Clathrin-independent endocytosis removes membrane receptors and other proteins from the cell surface, yet the mechanisms controlling this process remain unclear. Galectin-3 is now shown to regulate the biogenesis of a subpopulation of clathrin-independent carriers (CLICs). Galectin-3 binds to glycosylated cargo proteins and interacts with membrane glycosphingolipids to induce membrane deformation and CLIC formation.
authors.affiliation: Department of Cell Biology, Albert Einstein College of Medicine, New York, 10461, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Stanley
mesh_terms: D000818:Animals; D001798:Blood Proteins; D004705:Endocytosis; D037502:Galectin 3 / Q000378:metabolism*; D037161:Galectins; D006028:Glycosphingolipids / Q000378:metabolism*; D006801:Humans; D022161:Transport Vesicles / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; D006028:Glycosphingolipids; C428445:LGALS3 protein, human