title: Nanostructured lipid carriers as a potential vehicle for Carvedilol delivery: Application of factorial design approach.
abstract: Present invention relates to design of nanostructured lipid carriers (NLC) to augment oral bioavailability of Carvedilol (CAR). In this attempt, formulations of CAR-NLCs were prepared with glyceryl-monostearate (GMS) as a lipid, poloxamer 188 as a surfactant and tween 80 as a co-surfactant using high pressure homogenizer by 2(3) factorial design approach. Formed CAR-NLCs were assessed for various performance parameters. Accelerated stability studies demonstrated negligible change in particle size and entrapment efficiency, after storage at specified time up to 3 months. The promising findings in this investigation suggest the practicability of these systems for enhancement of bioavailability of drugs like CAR.
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Ganesh B
authors.initials: GB
authors.lastname: Patil
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Nandkishor D
authors.initials: ND
authors.lastname: Patil
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Deshmukh
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Pravin O
authors.initials: PO
authors.lastname: Patil
authors.affiliation: a Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka, Shirpur, Maharashtra , India.
authors.forename: Sanjay B
authors.initials: SB
authors.lastname: Bari
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry*; D002227:Carbazoles / Q000737:chemistry*; D000077261:Carvedilol; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D004355:Drug Stability; D005163:Factor Analysis, Statistical; D005989:Glycerides / Q000737:chemistry; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D011312:Pressure; D011412:Propanolamines / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D002227:Carbazoles; D004337:Drug Carriers; D005989:Glycerides; D011136:Polysorbates; D011412:Propanolamines; D000077261:Carvedilol; D020442:Poloxamer; C048159:glyceryl monostearate
keywords: design expert; high pressure homogenization; nanostructured lipid carrier