title: Search for new type of PPARγ agonist-like anti-diabetic compounds from medicinal plants.
abstract: Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPARγ agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii, piperlonguminine and retrofractamide A from the fruit of Piper chaba, and tetramethylkaempferol and pentamethylquercetin from the rhizomes of Kaempferia parviflora, are reviewed.
authors.affiliation: Kyoto Pharmaceutical University.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D006801:Humans; D031966:Hydrangea / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007333:Insulin Resistance; D015394:Molecular Structure; D047495:PPAR gamma / Q000819:agonists*; D031701:Piper / Q000737:chemistry*; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D028321:Plant Preparations