title: Trial evidence and approval of therapeutic agents--reply.
authors.affiliation: Yale University, New Haven, Connecticut.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Downing
authors.affiliation: Yale University, New Haven, Connecticut.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Ross
mesh_terms: D017277:Drug Approval; D016032:Randomized Controlled Trials as Topic; D014486:United States Food and Drug Administration