title: Early stage prostate cancer: biochemical recurrence after treatment.
abstract: OBJECTIVE
  To identify retrospectively through chart analysis the biochemical recurrence frequency of localized prostate cancer at diagnosis of patients submitted to surgery or radiotherapy; to correlate diagnostic characteristics associated with higher risk of biochemical recurrence.
  
  
  METHODS
  Retrospective analysis of 483 patients treated in a single center, from March 2000 to December 2009 in order to verify factors associated with biochemical recurrence.
  
  
  RESULTS
  Biochemical recurrence was more frequent in patients with higher initial PSA levels and those with higher risk disease. Recurrence was more frequent in patients with high risk (25.9%) than those with intermediate risk (10.7%)) and low risk (5.5%). There was no significant statistical difference of biochemical recurrence between patients submitted to radiotherapy or radical prostatectomy. Biochemical recurrence was diagnosed in only 11 of 73 patients (15%)) submitted to conformal radiotherapy using tridimensional technique.
  
  
  CONCLUSIONS
  Radiotherapy and radical prostatectomy have similar treatment results. Tridimensional conformal radiotherapy used nowadays is more efficient than earlier forms of radiation therapy (cobalt therapy and bidimensional linear accelerator therapy).
authors.affiliation: Assis Gurgacz Medical School, Cascavel, PR, Brazil.
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Zanatta
authors.affiliation: Department of Oncology, Cancer Hospital of Cascavel, UOPECCAN, Cascavel, PR, Brazil.
authors.forename: Reginaldo J
authors.initials: RJ
authors.lastname: Andrade
authors.affiliation: Brazilian Society of Urology, Rio de Janeiro, RJ, Brazil.
authors.forename: Eduardo F
authors.initials: EF
authors.lastname: Pacagnan
authors.affiliation: Assis Gurgacz Medical School, Cascavel, PR, Brazil.
authors.forename: Lucas W
authors.initials: LW
authors.lastname: München
authors.affiliation: Department of Statistics, Federal Technological University of Parana, UTFPR, Toledo, PR, Brazil.
authors.forename: Rosangela A B
authors.initials: RA
authors.lastname: Assumpção
authors.affiliation: Department of Radiotherapy, Cancer Hospital Cascavel - UOPECCAN, Cascavel, PR, Brazil.
authors.forename: Vanesssa C F I
authors.initials: VC
authors.lastname: Mercante
authors.affiliation: Department of Medical Physics, Cancer Hospital Cascavel - UOPECCAN, Cascavel, PR, Brazil.
authors.forename: Gustavo M D
authors.initials: GM
authors.lastname: Simonetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D020266:Radiotherapy, Conformal; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen