title: Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?
abstract: BACKGROUND
  Over the past 20 years, the idea that white adipose tissue (WAT) is simply an energy depot organ has been radically changed. Indeed, present understanding suggests WAT to be an endocrine organ capable of producing and secreting a wide variety of proteins termed adipokines. These adipokines appear to be relevant factors involved in a number of different functions, including metabolism, immune response, inflammation and bone metabolism.
  
  
  METHODS
  In this review, the authors focus on the effects of several adipose tissue-derived factors in bone pathophysiology. They also consider how the modification of the adipokine network could potentially lead to promising treatment options for bone diseases.
  
  
  CONCLUSIONS
  There are currently substantial developments being made in the understanding of the interplay between bone metabolism and the metabolic system. These insights could potentially lead to the development of new treatment strategies and interventions with the aim of successful outcomes in many people affected by bone disorders. Specifically, future research should look into the intimate mechanisms regulating peripheral and central activity of adipokines as it has potential for novel drug discovery.
authors.affiliation: Santiago University Clinical Hospital, SERGAS, Division of Rheumatology, Research Laboratory 9 , Santiago de Compostela, 15706 , Spain oreste.gualillo@sergas.es.
authors.forename: Morena
authors.initials: M
authors.lastname: Scotece
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.forename: Vanessa
authors.initials: V
authors.lastname: Abella
authors.forename: Verónica
authors.initials: V
authors.lastname: López
authors.forename: Jesús
authors.initials: J
authors.lastname: Pino
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gómez-Reino
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy* / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism; D015195:Drug Design; D055808:Drug Discovery; D006801:Humans; D007249:Inflammation / Q000378:metabolism
chemical_list: D054392:Adipokines
keywords: adipokines; bone; fat mass; osteoporosis