title: Association between two common polymorphisms and risk of hepatocellular carcinoma: evidence from an updated meta-analysis.
abstract: BACKGROUND
  Recent studies suggested that two common polymorphisms, miR-146a G>C and miR-196a2 C>T, may be associated with individual susceptibility to hepatocellular carcinoma (HCC). However, the results remain conflicting rather than conclusive. Object. The aim of this study was to assess the association between miR-146a G>C and miR-196a2 C>T polymorphisms and the risk of HCC.
  
  
  METHODS
  A meta-analysis of 17 studies (10938 cases and 11967 controls) was performed. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association.
  
  
  RESULTS
  For miR-146a G>C, the variant genotypes were associated with a decreased risk of HCC (CC versus GG: OR = 0.780 and 95% CI 0.700-0.869; GC/CC versus GG: OR = 0.865 and 95% CI 0.787-0.952; CC versus GC/GG: OR = 0.835 and 95% CI 0.774-0.901). For miR-196a2 C>T, significant association was also observed (TT versus CC: OR = 0.783, 95% CI: 0.649-0.943, and P = 0.010; CT versus CC: OR = 0.831, 95% CI 0.714-0.967, and P = 0.017; CT/TT versus CC: OR = 0.817, 95% CI 0.703-0.949, and P = 0.008).
  
  
  CONCLUSIONS
  The two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.
authors.affiliation: Department of General Surgery, The Affiliated Nanjing First Hospital with Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China ; Department of General Surgery, The First People's Hospital of Changzhou, Changzhou 213000, China.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The Affiliated Nanjing First Hospital with Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The Affiliated Nanjing First Hospital with Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Shi
authors.affiliation: The First Clinical Medical College, Nanjing Medical University, Nanjing 210000, China.
authors.forename: Huayu
authors.initials: H
authors.lastname: Xu
authors.affiliation: School of Public Health, Nanjing Medical University, Nanjing 210000, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The Affiliated Nanjing First Hospital with Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Bian
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000235:genetics*; D019317:Evidence-Based Medicine; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; C542542:MIRN146 microRNA, human; C542543:MIRN196 microRNA, human; D035683:MicroRNAs