title: An unusual case of mediastinal mass and bilateral nodules.
abstract: A 23-year-old woman presented with a mediastinal paraganglioma and multiple pulmonary chondromas following antral gastric resection for gastrointestinal stromal tumor. These tumors form the Carney triad, a rare disorder of unknown genetic background. First described in 1977, approximately 120 cases have been documented in the literature. The tumors do not harbor the specific c-kit or PDGFRA gene mutations often found in sporadic gastrointestinal stromal tumor. In most cases, gastric gastrointestinal stromal tumor is the first tumor to be detected, with secondary tumors appearing years later. Even if it is rare, Carney triad should be suspected in young patients with history of gastrointestinal stromal tumor.
authors.affiliation: Division of Visceral, Thoracic and Vascular Surgery, Department of Surgery, Stadtspital, Triemli, Zurich, Switzerland.
authors.forename: Charlotte Lilli Elena
authors.initials: CL
authors.lastname: Wichmann
authors.affiliation: Department of Pathology, Stadtspital Triemli, Zurich, Switzerland.
authors.forename: Birgit
authors.initials: B
authors.lastname: Helmchen
authors.affiliation: Department of Pathology, University Hospital Zurich, Switzerland.
authors.forename: Achim
authors.initials: A
authors.lastname: Weber
authors.affiliation: Department of Surgery, Stadtspital Waid, Zurich, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Wildi
authors.affiliation: Division of Visceral, Thoracic and Vascular Surgery, Department of Surgery, Stadtspital, Triemli, Zurich, Switzerland Division of Thoracic Surgery, University Hospital, Berne, Switzerland giovanni.carboni@triemli.zuerich.ch.
authors.forename: Giovanni Luca
authors.initials: GL
authors.lastname: Carboni
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D002812:Chondroma / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000601:surgery; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000601:surgery; D009154:Mutation; D010236:Paraganglioma, Extra-Adrenal / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000601:surgery; D000072078:Positron Emission Tomography Computed Tomography; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: Esophageal neoplasms; Gastrointestinal stromal tumors; Neoplasms; multiple primary