title: Improvement in diagnosis of metastatic pituitary carcinoma by 68Ga DOTATATE PET/CT.
abstract: Pituitary carcinoma is a rare disease with a challenge in both diagnosis and treatment. A 50-year-old female patient who underwent transsphenoidal resection of a pituitary tumor experienced progressive headache. For the evaluation, Ga DOTATATE PET/CT was used and compared with F-FDG PET/CT and enhanced MRI. Multiple lesions were detected by Ga DOTATATE PET/CT at the cerebral cortex, cerebellum, and cerebellopontine angle with a higher contrast than F-FDG PET/CT and enhanced MRI. With a biopsy, the patient was diagnosed as metastatic pituitary carcinoma. Moreover, it thus presents potential therapeutic implications on molecular-targeted therapy using somatostatin analogs and peptide receptor radionuclide therapy targeting the somatostatin receptors.
authors.affiliation: From the Departments of *Neurosurgery, †Nuclear Medicine, and ‡Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Jianqi
authors.initials: J
authors.lastname: Xiao
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhu
authors.forename: Dingrong
authors.initials: D
authors.lastname: Zhong
authors.forename: Wenbin
authors.initials: W
authors.lastname: Ma
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D009942:Organometallic Compounds; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate