title: Effects of intrathecal caffeic acid phenethyl ester and methylprednisolone on oxidant/antioxidant status in traumatic spinal cord injuries.
abstract: OBJECTIVE
  To examine the effect of intrathecally given caffeic acid phenethyl ester (CAPE) on peroxidation and total oxidant and antioxidant systems, and the effect of intrathecally given methylprednisolone (MP) in spinal cord injury (SCI) models.
  
  
  METHODS
  Four groups of 10 rats were formed: (1) Laminectomy, intrathecal saline injection, no SCI (sham: S); (2) Laminectomy, intrathecal saline injection, SCI (control: SCI); (3) Laminectomy, intrathecally given single dose of 3 mg/kg MP, SCISCI (SCI + MP). 4) Laminectomy, intrathecally given single dose of 1 µg/kg CAPE, SCI (SCI + CAPE). Malondialdehyde (MDA), total oxidant activity (TOA), total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) values in the spinal cord tissue were evaluated.
  
  
  RESULTS
  When group S and group SCI were compared, MDA, TOA, and SOD parameters increased post-SCI (p < 0.01). When compared with group SCI, it was observed that CAPE and MP decreased the MDA, TOA, and SOD levels (p < 0.01). This decrease was more pronounced in the SCI + CAPE group. When group S and group SCI were compared, a statistically substantial decrease was observed in the post-SCI TAC levels. When compared with group SCI, it was shown that CAPE and MP treatment substantially increased TAC levels (p < 0.001).
  
  
  CONCLUSIONS
  Intrathecal injection of both CAPE and MP inhibits lipid peroxidation and increase of oxidants in SCIs.
authors.affiliation: Department of Neurosurgery, University of Dicle, Diyarbakir, Turkey.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Gocmez
authors.affiliation: Department of Anesthesiology, University of Dicle, Diyarbakir, Turkey.
authors.forename: Feyzi
authors.initials: F
authors.lastname: Celik
authors.affiliation: Department of Neurosurgery, University of Dicle, Diyarbakir, Turkey.
authors.forename: Kagan
authors.initials: K
authors.lastname: Kamasak
authors.affiliation: Department of Neurosurgery, University of Fırat, Elazığ, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Kaplan
authors.affiliation: Department of Neurology, University of Dicle, Diyarbakir, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Uzar
authors.affiliation: Department of Neurology, University of Dicle, Diyarbakir, Turkey.
authors.forename: Adalet
authors.initials: A
authors.lastname: Arıkanoglu
authors.affiliation: Department of Biochemistry, University of Dicle, Diyarbakir, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002109:Caffeic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007278:Injections, Spinal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D008775:Methylprednisolone