title: Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones.
abstract: A highly diastereoselective and enantioselective method for the asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones using the Michael addition reaction of malonates under catalysis with the primary amine-thiourea conjugate catalyst and PPY at high pressure was developed.
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan. kotsuki@kochi-u.ac.jp.
authors.forename: Naomu
authors.initials: N
authors.lastname: Miyamae
authors.forename: Naruhisa
authors.initials: N
authors.lastname: Watanabe
authors.forename: Maya
authors.initials: M
authors.lastname: Moritaka
authors.forename: Keiji
authors.initials: K
authors.lastname: Nakano
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Hiyoshizo
authors.initials: H
authors.lastname: Kotsuki
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D053138:Cyclohexenes / Q000138:chemical synthesis* / Q000737:chemistry; D011312:Pressure; D066244:Proton Magnetic Resonance Spectroscopy; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D053138:Cyclohexenes; D012997:Solvents; C507608:cyclohexadienone