title: The Montreal cognitive assessment to screen for cognitive impairment in HIV patients older than 60 years.
abstract: Progress in HIV treatments has led to HIV-infected patients living into their 60s and older. Because HIV-associated neurocognitive disorder (HAND) in older age is associated with more executive dysfunction, cognitive screening instruments tapping this domain may be optimal. We examined the Montreal Cognitive Assessment to identify HAND in 67 HIV-infected patients older than 60 years, of which 40% were diagnosed with HAND. Receiver operating characteristic curve identified an optimal cutpoint of ≤ 25 for HAND with a sensitivity of 72% and specificity of 67%. We conclude that the Montreal Cognitive Assessment has only moderate performance characteristics for cognitive screening of HIV-infected elders.
authors.affiliation: *Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy; †Memory and Aging Center, Department of Neurology, University of California-San Francisco, San Francisco, CA; ‡Department of Veterans Affairs Medical Center San Francisco San Francisco, CA; §Department of Community Health Systems, School of Nursing, University of California-San Francisco, San Francisco, CA; and ‖Division of Geriatric Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Milanini
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Wendelken
authors.forename: Pardis
authors.initials: P
authors.lastname: Esmaeili-Firidouni
authors.forename: Maggie
authors.initials: M
authors.lastname: Chartier
authors.forename: Pierre-Cedric
authors.initials: PC
authors.lastname: Crouch
authors.forename: Victor
authors.initials: V
authors.lastname: Valcour
mesh_terms: D000367:Age Factors; D000368:Aged; D019540:Area Under Curve; D003072:Cognition Disorders / Q000821:virology*; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity