title: Kinetic analysis of 2-([(18)F]fluoro)-2-deoxy-d-glucose uptake in brains of anesthetized healthy dogs.
abstract: OBJECTIVE
  To assess kinetic 2-([(18)F]fluoro)-2-deoxy-d-glucose ((18)FDG) uptake in the brain of anesthetized healthy adult dogs by use of positron emission tomography (PET) and to determine whether (18)FDG uptake differs among anatomic regions of the brain.
  
  
  METHODS
  5 healthy Beagles.
  
  
  METHODS
  Each isoflurane-anesthetized dog was administered (18)FDG IV (dose range, 3.0 to 5.2 mCi), and PET data were acquired for 2 hours. A CT scan (without contrast agent administration) was performed to allow more precise neuroanatomic localization. Defined regions of interest within the brain were drawn on reconstructed image data. Standard uptake values (SUVs) for (18)FDG were calculated to generate time-activity curves and determine time to peak uptake.
  
  
  RESULTS
  Time-activity curve analysis identified 4 regional uptake patterns: olfactory, gray matter, white matter, and other (brainstem, cerebellum, and occipital and frontal regions). The highest maximum SUVs were identified in the olfactory bulbs and cerebral gray matter, and the lowest maximum SUV was identified in cerebral white matter. Mean time to peak uptake ranged from 37.8 minutes in white matter to 82.7 minutes in the olfactory bulbs.
  
  
  CONCLUSIONS
  Kinetic analysis of (18)FDG uptake revealed differences in uptake values among anatomic areas of the brain in dogs. These data provide a baseline for further investigation of (18)FDG uptake in dogs with immune-mediated inflammatory brain disease and suggest that (18)FDG-PET scanning has potential use for antemortem diagnosis without histologic analysis and for monitoring response to treatment. In clinical cases, a 1-hour period of PET scanning should provide sufficient pertinent data.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996.
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Williams
authors.forename: Federica
authors.initials: F
authors.lastname: Morandi
authors.forename: Dustin R
authors.initials: DR
authors.lastname: Osborne
authors.forename: Jill
authors.initials: J
authors.lastname: Narak
authors.forename: Amy K
authors.initials: AK
authors.lastname: LeBlanc
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004285:Dogs / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007530:Isoflurane; D008297:Male; D015233:Models, Statistical; D049268:Positron-Emission Tomography / Q000379:methods / Q000662:veterinary; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D007530:Isoflurane