title: Association study between macrophage migration inhibitory factor-173 polymorphism and acute myeloid leukemia in Taiwan.
abstract: Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays a significant role in pathogenesis and autoimmune diseases. The major function of MIF is to promote the cell proliferation, migration, and invasion. The aim of the present study is to identify the association between MIF-173 (rs755662) single nucleotide polymorphism (SNP) and AML in Taiwanese population. DNA samples extracted from 256 AML patients and 256 healthy controls were investigated using polymerase chain reaction followed by restriction fragment length polymorphism analysis. The association between MIF-173 SNP genotype and AML patients were assessed with SPSS software. The results show that the GC genotype of MIF-173 SNP is significantly higher in AML patients than in the healthy controls (OR 1.58, 95 % CI 1.06, P = 0.034). Carrier genotypes GC and CC may be a causative factor for AML cancer (OR 1.39, 95 % CI 0.95, P = 0.085). White blood cell count (10(3)/µl) were significantly associated with AML MIF-173 polymorphism patients (P = 0.002). Our results in this study provide the first evidence that the MIF-173 polymorphism is associated with AML. MIF is a potential biomarker for development of AML cancer in male adult in Taiwanese population. Further validations in other populations are warranted.
authors.affiliation: Department of Biomedical Informatics, Asia University, Taichung, Taiwan.
authors.forename: Latha
authors.initials: L
authors.lastname: Ramireddy
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Su-Ching
authors.initials: SC
authors.lastname: Liu
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Lo
authors.forename: Rouh-Mei
authors.initials: RM
authors.lastname: Hu
authors.forename: Yi-Chin
authors.initials: YC
authors.lastname: Peng
authors.forename: Ching-Tien
authors.initials: CT
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013624:Taiwan
chemical_list: D008263:Macrophage Migration-Inhibitory Factors