title: Systematic review of the economic value of diarrheal vaccines.
abstract: Diarrheal disease is a leading cause of child mortality in low-income settings and morbidity across a range of settings. A growing number of studies have addressed the economic value of new and emerging vaccines to reduce this threat. We conducted a systematic review to assess the economic value of diarrheal vaccines targeting a range of pathogens in different settings. The majority of studies focused on the economic value of rotavirus vaccines in different settings, with most of these concluding that vaccination would provide significant economic benefits across a range of vaccine prices. There is also evidence of the economic benefits of cholera vaccines in specific contexts. For other potential diarrheal vaccines data are limited and often hypothetical. Across all target pathogens and contexts, the evidence of economic value focuses the short-term health and economic gains. Additional information is needed on the broader social and long-term economic value of diarrhea vaccines.
authors.affiliation: Department of Environmental and Global Health; Emerging Pathogens Institute; University of Florida; Gainesville, FL USA; Department of Health Services Research, Management & Policy; College of Public Health and Health Professions; University of Florida; Gainesville, FL USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Rheingans
authors.affiliation: Department of Health Services Research, Management & Policy; College of Public Health and Health Professions; University of Florida; Gainesville, FL USA.
authors.forename: Mirna
authors.initials: M
authors.lastname: Amaya
authors.affiliation: Department of Environmental and Global Health; Emerging Pathogens Institute; University of Florida; Gainesville, FL USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Anderson
authors.affiliation: Department of Environmental and Global Health; Emerging Pathogens Institute; University of Florida; Gainesville, FL USA.
authors.forename: Poulomy
authors.initials: P
authors.lastname: Chakraborty
authors.affiliation: Department of Environmental and Global Health; Emerging Pathogens Institute; University of Florida; Gainesville, FL USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Atem
mesh_terms: D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000191:economics*; D003362:Cost-Benefit Analysis; D003967:Diarrhea / Q000191:economics* / Q000517:prevention & control; D005759:Gastroenteritis / Q000191:economics* / Q000517:prevention & control*; D006801:Humans; D014765:Viral Vaccines / Q000008:administration & dosage / Q000191:economics*
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines
keywords: cost-effectiveness; diarrhea; economic; enteric; vaccine; value