title: Free triiodothyronine in hemodialysis patients: link with malnutrition and inflammation.
abstract: BACKGROUND
  Free triiodothyronine (FT3) is a marker of comorbidity in end-stage renal disease and in many acute and chronic diseases. There is lack of data about the link between FT3 levels and malnutrition and inflammation in hemodialysis patients. The objective of the present study was to investigate the link between FT3 and malnutrition and inflammation in hemodialysis patients.
  
  
  METHODS
  A total of 84 patients were included in the study (38 men and 46 women; mean age, 56.2 +/- 14.8 years; hemodialysis duration, 95.72 +/- 10.35 months). Serum FT3, free thyroxin, and thyroid-stimulating hormone concentrations were determined. Demographic data and laboratory values were evaluated. Patients' comorbidity status was determined using the Charlson Comorbidity Index (CCI), and malnutrition-inflammation status was determined by Malnutrition-Inflammation Score (MIS).
  
  
  RESULTS
  Serum FT3 concentration inversely correlated with age (r = -0.328, P = .002), CCI (r = -0.591, P = .001), C-reactive protein (r = -0.299, P = .01), and MIS (r = -0.671, P = .001), and positively correlated with serum albumin (r = 0.389, P = .001). In multivariate linear regression analysis, FT3 was independently associated with MIS (beta;, -0.14; 95% confidence interval, -0.175 to 0.063, P = .003), adjusted for CCI, C-reactive protein level, serum albumin level, and MIS.
  
  
  CONCLUSIONS
  The results of this study indicate that FT3 is negatively correlated with inflammatory markers, namely C-reactive protein, and it is independently related with MIS in hemodialysis patients. Therefore, we suggest that FT3 can be accepted as an inflammatory marker in hemodialysis patients.
authors.affiliation: Baskent University Faculty of Medicine, Nefrology, Ankara, Turkey. demetdolu@hotmail.com.
authors.forename: Demet
authors.initials: D
authors.lastname: Yavuz
authors.forename: Siren
authors.initials: S
authors.lastname: Sezer
authors.forename: Rahman
authors.initials: R
authors.lastname: Yavuz
authors.forename: Mujdat Batur
authors.initials: MB
authors.lastname: Canoz
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Altunoglu
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Altinoglu
authors.forename: Rengin
authors.initials: R
authors.lastname: Elsürer
authors.forename: Zubeyde
authors.initials: Z
authors.lastname: Arat
authors.forename: Fatma Nurhan
authors.initials: FN
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D044342:Malnutrition / Q000209:etiology*; D008875:Middle Aged; D006435:Renal Dialysis; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014284:Triiodothyronine; D013972:Thyrotropin; D002097:C-Reactive Protein; D013974:Thyroxine