title: Magnetic solid-phase extraction based on mesoporous silica-coated magnetic nanoparticles for analysis of oral antidiabetic drugs in human plasma.
abstract: In the present work, magnetic nanoparticles embedded into mesoporous silica were prepared in two steps: first, magnetite was synthesized by oxidation-precipitation method, and next, the magnetic nanoparticles were coated with mesoporous silica by using nonionic block copolymer surfactants as structure-directing agents. The mesoporous SiO2-coated Fe3O4 samples were functionalized using octadecyltrimethoxysilane as silanizing agent. The pure and functionalized silica nanoparticles were physicochemically and morphologically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), N2 adsorption, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The resultant magnetic silica nanoparticles were applied as sorbents for magnetic solid-phase extraction (MSPE) of oral antidiabetic drugs in human plasma. Our results revealed that the magnetite nanoparticles were completely coated by well-ordered mesoporous silica with free pores and stable pore walls, and that the structural and magnetic properties of the Fe3O4 nanoparticles were preserved in the applied synthesis route. Indeed, the sorbent material was capable of extracting the antidiabetic drugs from human plasma, being useful for the sample preparation in biological matrices.
authors.affiliation: Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Rua Professor Mário Werneck, s/n. Campus Universitário, Belo Horizonte, MG CEP 30.123-970, Brazil.
authors.forename: Karynne Cristina
authors.initials: KC
authors.lastname: de Souza
authors.affiliation: Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Rua Professor Mário Werneck, s/n. Campus Universitário, Belo Horizonte, MG CEP 30.123-970, Brazil.
authors.forename: Gracielle Ferreira
authors.initials: GF
authors.lastname: Andrade
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Vasconcelos
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Iara Maíra
authors.initials: IM
authors.lastname: de Oliveira Viana
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Christian
authors.initials: C
authors.lastname: Fernandes
authors.affiliation: Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Rua Professor Mário Werneck, s/n. Campus Universitário, Belo Horizonte, MG CEP 30.123-970, Brazil. Electronic address: sousaem@cdtn.br.
authors.forename: Edésia Martins Barros
authors.initials: EM
authors.lastname: de Sousa
mesh_terms: D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D052616:Solid Phase Extraction
chemical_list: D007004:Hypoglycemic Agents; D058185:Magnetite Nanoparticles; C509969:SBA-15; D012821:Silanes; C024779:octadecylsilane; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide
keywords: Magnetic nanoparticles; Magnetic solid phase extraction; Mesoporous materials; Oral antidiabetic drug extraction