title: Extravirologic modulation of immune response by an NRTI-sparing antiretroviral regimen including darunavir and maraviroc.
abstract: Dual therapies, including protease inhibitor + maraviroc (MVC), may represent an alternative to traditional regimens for management of HIV infection. The aim of this in vitro study was to assess the effects of darunavir (DRV) alone or in combination with MVC on cell apoptosis and chemotaxis. A significant decrease of cell apoptosis was found after DRV treatment. The addition of MVC to DRV also had an in vitro down-regulating effect on cell migration. The combination of an NRTI-sparing regimen including DRV+ MVC may have a potential role in immune system modulation by the direct down regulation of apoptosis and chemotaxis.
authors.affiliation: Department of Public Health and Infectious Diseases, Sapienza University, Istituto Pasteur-Fondazione Cenci-Bolognetti, Rome, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Ermocida
authors.forename: Fabio
authors.initials: F
authors.lastname: Mengoni
authors.forename: Ilaria
authors.initials: I
authors.lastname: Sauzullo
authors.forename: Raffaella
authors.initials: R
authors.lastname: Rossi
authors.forename: Camilla
authors.initials: C
authors.lastname: Ajassa
authors.forename: Miriam
authors.initials: M
authors.lastname: Lichtner
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Mastroianni
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vullo
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002478:Cells, Cultured; D003510:Cyclohexanes / Q000494:pharmacology*; D000069454:Darunavir; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D000077592:Maraviroc; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013449:Sulfonamides / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D003510:Cyclohexanes; D013449:Sulfonamides; D014230:Triazoles; D000077592:Maraviroc; D000069454:Darunavir