title: A rare case of acute renal failure secondary to rhabdomyolysis probably induced by donepezil.
abstract: Introduction. Acute renal failure (ARF) develops in 33% of the patients with rhabdomyolysis. The main etiologic factors are alcoholism, trauma, exercise overexertion, and drugs. In this report we present a rare case of ARF secondary to probably donepezil-induced rhabdomyolysis. Case Presentation. An 84-year-old male patient was admitted to the emergency department with a complaint of generalized weakness and reduced consciousness for two days. He had a history of Alzheimer's disease for one year and he had taken donepezil 5 mg daily for two months. The patient's physical examination revealed apathy, loss of cooperation, and decreased muscle strength. Laboratory studies revealed the following: urea: 128 mg/dL; Creatinine 6.06 mg/dL; creatine kinase: 3613 mg/dL. Donepezil was discontinued and the patient's renal function tests improved gradually. Conclusion. Rhabdomyolysis-induced acute renal failure may develop secondary to donepezil therapy.
authors.affiliation: Department of Nephrology, Recep Tayyip Erdogan University Medical School, 53100 Rize, Turkey.
authors.forename: Osman Zikrullah
authors.initials: OZ
authors.lastname: Sahin
authors.affiliation: Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53100 Rize, Turkey.
authors.forename: Teslime
authors.initials: T
authors.lastname: Ayaz
authors.affiliation: Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53100 Rize, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Yuce
authors.affiliation: Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53100 Rize, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Sumer
authors.affiliation: Department of Endocrinology and Metabolic Disease, Recep Tayyip Erdogan University Medical School, 53100 Rize, Turkey.
authors.forename: Serap Baydur
authors.identifier: 0000-0002-3944-136X
authors.initials: SB
authors.lastname: Sahin