title: Impact of exercise-based cardiac rehabilitation on de novo coronary lesion in patients with drug eluting stent.
abstract: OBJECTIVE
  To compare the rate of progression of de novo lesion between the cardiac rehabilitation (CR) and control groups.
  
  
  METHODS
  This is a retrospective observational study. Patients who received drug-eluting stent (DES) due to acute coronary syndrome were included as subjects. The CR group received eight weeks of early CR program, and sustained a self-exercise program in the homes. The control group was instructed to exercise independently. Nine months after the first insertion of DES, we implemented follow-up coronary angiography, and compared the rate of progression of de novo lesion by quantitative angiographic measurement between the two groups.
  
  
  RESULTS
  A total of 81 patients were recruited as subjects to CR group (n=32) or control group (n=49). At nine months, late luminal loss was 0.04±0.23 mm in the CR group and 0.00±0.31 mm in the control group (p=0.54, observed power=0.10). Late loss was -0.90%±9.53% in the CR group and 0.80%±11.15% in the control group (p=0.58, observed power=0.05). No target lesion revascularization procedures were needed in the CR group, while two in the control group (p=0.25). In the CR group, mean VO2max was significantly improved from 24.36±5.00 to 27.68±5.24 mL/kg/min (p<0.001).
  
  
  CONCLUSIONS
  We could not observe a statistically significant difference in the progression rate of de novo lesion between the CR and control groups. Thus the current amount of nine months exercise-based CR program does not seem to have a distinct impact on the retardation of de novo coronary lesion in patients who received percutaneous coronary intervention with DES.
authors.affiliation: Department of Rehabilitation Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Hee Eun
authors.initials: HE
authors.lastname: Choi
authors.affiliation: Department of Rehabilitation Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Byeong Ju
authors.initials: BJ
authors.lastname: Lee
authors.affiliation: Department of Rehabilitation Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Chul
authors.initials: C
authors.lastname: Kim
keywords: Coronary stenosis; Drug-eluting stents; Exercise; Rehabilitation