title: Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community: the northern Manhattan study.
abstract: OBJECTIVE
  Migraine with aura is a risk factor for ischemic stroke. The goals of this study are to examine the association between migraine and subclinical cerebrovascular damage in a race/ethnically diverse older population-based cohort study.
  
  
  METHODS
  In the Northern Manhattan Study (NOMAS), we quantified subclinical brain infarctions and white matter hyperintensity volumes among participants with self-reported migraine, confirmed by the International Classification of Headache Disorders-2 criteria.
  
  
  RESULTS
  Of 546 study participants with imaging and migraine data (41% men; mean age at MRI, 71±8 years; mostly Hispanic [65%]), those reporting migraine overall had double the odds of subclinical brain infarction (adjusted odds ratio, 2.1; 95% confidence interval, 1.0-4.2) when compared with those reporting no migraine, after adjusting for sociodemographics and vascular risk factors. No association was observed between migraine with or without aura and white matter hyperintensity volume.
  
  
  CONCLUSIONS
  Migraine may be a risk factor for subclinical brain infarction. Prospective studies are needed in race/ethnically diverse populations.
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli). tmonteith@med.miami.edu.
authors.forename: Teshamae
authors.initials: T
authors.lastname: Monteith
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Hannah
authors.initials: H
authors.lastname: Gardener
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Tatjana
authors.initials: T
authors.lastname: Rundek
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Chuanhui
authors.initials: C
authors.lastname: Dong
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yoshita
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Mitchell S V
authors.initials: MS
authors.lastname: Elkind
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Ralph L
authors.initials: RL
authors.lastname: Sacco
authors.affiliation: From the Department of Neurology, School of Medicine, University of Miami, FL (T.M., H.G., T.R., C. Dong, R.L.S., C.B.W.); Department of Neurology, Hokuriku National Hospital, Nanto, Japan (M.Y.); Department of Neurology, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.); and Department of Neurology, Imaging of Dementia and Aging Laboratory, University of California, Davis (C. DeCarli).
authors.forename: Clinton B
authors.initials: CB
authors.lastname: Wright
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D002540:Cerebral Cortex; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D020326:Migraine without Aura / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D012307:Risk Factors
keywords: biological markers; cerebral infarction; epidemiology; ethnic groups; leukoaraiosis; migraine disorders; risk factors