title: The postprandial situation as a pro-inflammatory condition.
abstract: Postprandial lipemia has been associated with cardiovascular disease. The current pathophysiological concept is that postprandial remnant lipoproteins migrate into the subendothelial space and that remnants activate circulating leukocytes and endothelial cells. Activated monocytes adhere to endothelial adhesion molecules, facilitating subendothelial migration of monocytes. These cells differentiate into macrophages, with the risk of foam cell formation, due to uptake of remnants and modified lipoproteins. Evidence is emerging that specific interventions may reduce the atherogenic postprandial inflammation. Fruits rich in polyphenols, virgin olive oil, carotenoids and exercise have recently been found to reduce postprandial inflammation. Pharmaceutical interventions with fibrates or statins not only improve the overall lipid profile, but reduce postprandial inflammation as well. This review will deal with the current concept of postprandial inflammation in relation to the development of atherosclerosis and potential interventions to reduce postprandial inflammation.
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Marijke A
authors.initials: MA
authors.lastname: de Vries
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Boudewijn
authors.initials: B
authors.lastname: Klop
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Silvia A
authors.initials: SA
authors.lastname: Eskes
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Theo L J M
authors.initials: TL
authors.lastname: van der Loos
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Françoise J M
authors.initials: FJ
authors.lastname: Klessens-Godfroy
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Janneke
authors.initials: J
authors.lastname: Wiebolt
authors.affiliation: Department of Clinical Chemistry, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Hans W
authors.initials: HW
authors.lastname: Janssen
authors.affiliation: Department of Clinical Pharmacy, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Elsbeth M
authors.initials: EM
authors.lastname: Westerman
authors.affiliation: Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands. Electronic address: m.castrocabezas@sfg.nl.
authors.forename: Manuel
authors.initials: M
authors.lastname: Castro Cabezas
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D005487:Foam Cells / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D007249:Inflammation / Q000209:etiology* / Q000517:prevention & control; D007962:Leukocytes / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D019518:Postprandial Period
chemical_list: D008074:Lipoproteins
keywords: Apolipoprotein B48; Apolipoproteína B48; Ateroesclerosis; Atherosclerosis; Chylomicron; Quilomicrón; Triglicéridos; Triglyceride