title: Human nerual stem cells for brain repair.
abstract: Cell replacement therapy and gene transfer to the diseased or injured brain have provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases including Parkinson disease, Huntington disease, amyotrophic lateral sclerosis (ALS), Alzheimer disease, multiple sclerosis (MS), stroke, spinal cord injury and brain cancer. In recent years, neurons and glial cells have successfully been generated from neural stem cells, and extensive efforts by investigators to develop neural stem cell-based transplantation therapies have been carried out. We review here notable experimental and pre-clinical studies we have previously conducted involving human neural stem cell-based cell- and gene-therapies for Parkinson disease, Huntington disease, ALS, stroke and brain cancer.
authors.affiliation: Institute for Regenerative Medicine, Gachon Medical University Gil Hospital, Incheon, Korea ; Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Seung U
authors.initials: SU
authors.lastname: Kim
authors.affiliation: Institute for Regenerative Medicine, Gachon Medical University Gil Hospital, Incheon, Korea.
authors.forename: Hong J
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Institute for Regenerative Medicine, Gachon Medical University Gil Hospital, Incheon, Korea.
authors.forename: In H
authors.initials: IH
authors.lastname: Park
authors.affiliation: Department of Neurology Seoul National University Hospital, Seoul, Korea.
authors.forename: Kon
authors.initials: K
authors.lastname: Chu
authors.affiliation: Department of Neurology Seoul National University Hospital, Seoul, Korea.
authors.forename: Soon T
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Department of Neurology Seoul National University Hospital, Seoul, Korea.
authors.forename: Manho
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Neurology Seoul National University Hospital, Seoul, Korea.
authors.forename: Jae K
authors.initials: JK
authors.lastname: Roh
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Seung K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Kyu C
authors.initials: KC
authors.lastname: Wang
keywords: Amyotrophic lateral sclerosis; Brain cancer; Cell therapy; Gene transfer; Human neural stem cell; Huntington disease; Neurodegenrative diseases; Parkinson disease; Stem cell; Stroke; Transplantation