title: Calcifying odontogenic cyst: a rare report of a nonneoplastic variant associated with cholesterol granuloma.
abstract: OBJECTIVE
  To report a case of a non-neoplastic variant of calcifying odontogenic cyst (COC) with the lining epithelium showing ameloblastomatous proliferation and capsule exhibiting features of a cholesterol granuloma. The importance of delineating this histologic variant from unicystic ameloblastoma and the formation of cholesterol granuloma in this variant is discussed.
  
  
  BACKGROUND
  Calcifying odontogenic cyst is a developmental jaw cyst, which presents itself as both the neoplastic and the non-neoplastic forms. The ameloblastomatous variant of COC is often mistaken for unicystic ameloblastoma and treated aggressively.
  
  
  METHODS
  A 68-year-old female who presented with a cystic enlargement of the posterior mandible on the right side was suggestive of unicystic ameloblastoma based on radiography and initial biopsy report. Microscopic examination of the excision specimen, however, was fitting in favor of calcifying odontogenic cyst with ameloblastomatous proliferation.
  
  
  CONCLUSIONS
  Identifying the non-neoplastic ameloblastomatous variant of COC from a cystic ameloblastoma is crucial as the treatment of the two lesions vary considerably.
  
  
  CONCLUSIONS
  This case emphasizes the need for thorough examination of the entire surgical specimen before arriving at an appropriate diagnosis.
authors.affiliation: Postgraduate Student, Department of Oral and Maxillofacial Pathology Manipal College of Dental Sciences, Manipal, Karnataka, India.
authors.forename: Manikkath
authors.initials: M
authors.lastname: Aparna
authors.affiliation: Postgraduate Student, Department of Oral and Maxillofacial Surgery Manipal College of Dental Sciences, Manipal, Karnataka, India.
authors.forename: Mukund
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Postgraduate Student, Department of Oral Medicine and Radiology Manipal College of Dental Sciences, Manipal, Karnataka, India.
authors.forename: Nanditha
authors.initials: N
authors.lastname: Sujir
authors.affiliation: Professor and Head, Department of Oral and Maxillofacial Surgery Manipal College of Dental Sciences, Manipal, Karnataka, India.
authors.forename: Abhay
authors.initials: A
authors.lastname: Kamath
authors.affiliation: Professor, Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.
authors.forename: Monica
authors.initials: M
authors.lastname: Solomon
authors.affiliation: Professor and Head, Department of Oral Medicine and Radiology Manipal College of Dental Sciences, Manipal, Karnataka, India.
authors.forename: Keerthilatha
authors.initials: K
authors.lastname: Pai
authors.affiliation: Professor and Head, Department of Oral and Maxillofacial Pathology Manipal College of Dental Sciences, Manipal, Karnataka, India, e-mail: raghu.radhakrishnan@gmail.com.
authors.forename: Raghu
authors.initials: R
authors.lastname: Radhakrishnan
mesh_terms: D000368:Aged; D000564:Ameloblastoma / Q000175:diagnosis; D001706:Biopsy / Q000379:methods; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000473:pathology; D015745:Granuloma, Foreign-Body / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018333:Odontogenic Cyst, Calcifying / Q000175:diagnosis* / Q000473:pathology; D009807:Odontogenic Cysts / Q000175:diagnosis; D011862:Radiography, Panoramic / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods