title: Increased levels of plasma CXC-Chemokine Ligand 10, 12 and 16 are associated with right ventricular function in patients with idiopathic pulmonary arterial hypertension.
abstract: OBJECTIVE
  To investigate plasma levels of CXC-Chemokine Ligand 10 (CXCL10), CXC-Chemokine Ligand 12 (CXCL12) and CXC-Chemokine Ligand 16 (CXCL16) in patients with idiopathic pulmonary arterial hypertension (IPAH).
  
  
  METHODS
  Plasma levels of biomarkers were measured by enzyme-linked immunosorbent assay in 61 patients with IPAH and 20 healthy volunteers.
  
  
  RESULTS
  Plasma CXCL10, CXCL12 and CXCL16 concentrations were increased significantly in IPAH patients compared with controls, and significantly correlated with N-terminal pro-brain natriuretic peptide, tricuspid annulus plane systolic excursion and right ventricular ejection fraction.
  
  
  CONCLUSIONS
  Increased levels of CXCL10, CXCL12 and CXCL16 are associated with right ventricular dysfunction in patients with IPAH.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Zhen-Nan
authors.initials: ZN
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Ni
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Xian-Min
authors.initials: XM
authors.lastname: Meng
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China. Electronic address: xiongcm2000@163.com.
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beilishi Road, Xicheng District, Beijing 100037, China. Electronic address: hejianguofw@gmail.com.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: He
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood; D054377:Chemokine CXCL12 / Q000097:blood; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood*; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D051116:Receptors, Scavenger / Q000097:blood; D013318:Stroke Volume; D018497:Ventricular Dysfunction, Right / Q000097:blood; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D015415:Biomarkers; C423727:CXCL16 protein, human; D054357:Chemokine CXCL10; D054377:Chemokine CXCL12; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger
keywords: Biomarkers; CXC-chemokine ligand; Pulmonary arterial hypertension; Right ventricular function