title: The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage.
abstract: Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.
authors.affiliation: Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
authors.forename: Blessing N R
authors.initials: BN
authors.lastname: Jaja
authors.forename: Daniel
authors.initials: D
authors.lastname: Attalla
authors.forename: R Loch
authors.initials: RL
authors.lastname: Macdonald
authors.forename: Tom A
authors.initials: TA
authors.lastname: Schweizer
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
authors.forename: Nima
authors.initials: N
authors.lastname: Etminan
authors.forename: Daniel
authors.initials: D
authors.lastname: Hanggi
authors.forename: David
authors.initials: D
authors.lastname: Hasan
authors.forename: S Claiborne
authors.initials: SC
authors.lastname: Johnston
authors.forename: Peter
authors.initials: P
authors.lastname: Le Roux
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lo
authors.forename: Ada
authors.initials: A
authors.lastname: Louffat-Olivares
authors.forename: Stephan
authors.initials: S
authors.lastname: Mayer
authors.forename: Andrew
authors.initials: A
authors.lastname: Molyneux
authors.forename: Adam
authors.initials: A
authors.lastname: Noble
authors.forename: Audrey
authors.initials: A
authors.lastname: Quinn
authors.forename: Thomas
authors.initials: T
authors.lastname: Schenk
authors.forename: Julian
authors.initials: J
authors.lastname: Spears
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Singh
authors.forename: Michael
authors.initials: M
authors.lastname: Todd
authors.forename: James
authors.initials: J
authors.lastname: Torner
authors.forename: Ming
authors.initials: M
authors.lastname: Tseng
authors.forename: William
authors.initials: W
authors.lastname: van den Bergh
authors.forename: Mervyn D I
authors.initials: MD
authors.lastname: Vergouwen
authors.forename: George K C
authors.initials: GK
authors.lastname: Wong
mesh_terms: D035843:Biomedical Research; D016208:Databases, Factual; D006801:Humans; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D016896:Treatment Outcome