title: IL-17F but not IL-17A gene polymorphism confers risk to multiple sclerosis in a Chinese Han population.
abstract: Interleukin-17 has been shown to be associated with autoimmune disease. The aim of the current study is to investigate the potential association of IL-17 polymorphisms with multiple sclerosis (MS) in Chinese Han patients. Two SNPs, rs763780 of IL-17F gene and rs2275913 of IL-17A gene were genotyped in 622 MS patients and 743 healthy controls by using a polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Allele and genotype frequencies distribution of the two SNPs were examined between patients and controls using the Chi-Square test. All genotypic and allelic frequencies of the tested IL-17 polymorphisms in control cohort were in Hardy-Weinberg equilibrium. A significantly increased frequency of rs763780 TT genotype (corrected p value (Pc)=0.024, odds ratio=1.472, 95% CI=1.133-1.913) and T allele (corrected P (Pc)=0.018, odds ratio=1.446, 95% CI=1.134-1.844) was detected in MS patients compared with controls. The genotypic and allelic frequencies of rs2275913 in IL-17A gene were not different between patients with MS and controls. These results suggest that rs763780 is associated with multiple sclerosis in a Chinese Han population.
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Sichuan, PR China.
authors.forename: Shunxian
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, PR China. Electronic address: doctorzhaihong@gmail.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhai
authors.affiliation: Department of Biology, Western Oregon University, Monmouth, OR, USA.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Sichuan, PR China; Institute of Neurology, North Sichuan Medical College, Sichuan, PR China.
authors.forename: Yinxu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
keywords: Association; IL-17; Multiple sclerosis (MS); PCR-RFLP; Polymorphism; SNP