title: Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model.
abstract: Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C- β -d-glucopyranoside (1), 6,8,3',4'-tetrahydroxyflavanone-7-C- β -d-glucopyranoside (2), 6,8,4'-trihydroxyflavanone-7-C- β -d-glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O- β -d-allopyranoside (4), and epiphyllocoumarin-3-O- β -d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.
authors.affiliation: School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan ; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Chen-Yu
authors.identifier: 0000-0003-0030-1797
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 333, Taiwan.
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Huang
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
authors.forename: Keng-Chang
authors.identifier: 0000-0001-8277-9174
authors.initials: KC
authors.lastname: Tsai
authors.affiliation: School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan ; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Wei-Jan
authors.initials: WJ
authors.lastname: Huang
authors.affiliation: Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 333, Taiwan.
authors.forename: Wen-Ching
authors.initials: WC
authors.lastname: Huang
authors.affiliation: School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan ; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Hsu
authors.affiliation: School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan ; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Feng-Lin
authors.initials: FL
authors.lastname: Hsu