title: An investigation into the effects of temporal resolution on hepatic dynamic contrast-enhanced MRI in volunteers and in patients with hepatocellular carcinoma.
abstract: This study investigated the effect of temporal resolution on the dual-input pharmacokinetic (PK) modelling of dynamic contrast-enhanced MRI (DCE-MRI) data from normal volunteer livers and from patients with hepatocellular carcinoma. Eleven volunteers and five patients were examined at 3 T. Two sections, one optimized for the vascular input functions (VIF) and one for the tissue, were imaged within a single heart-beat (HB) using a saturation-recovery fast gradient echo sequence. The data was analysed using a dual-input single-compartment PK model. The VIFs and/or uptake curves were then temporally sub-sampled (at interval ▵t = [2-20] s) before being subject to the same PK analysis. Statistical comparisons of tumour and normal tissue PK parameter values using a 5% significance level gave rise to the same study results when temporally sub-sampling the VIFs to HB < ▵t <4 s. However, sub-sampling to ▵t > 4 s did adversely affect the statistical comparisons. Temporal sub-sampling of just the liver/tumour tissue uptake curves at ▵t ≤ 20 s, whilst using high temporal resolution VIFs, did not substantially affect PK parameter statistical comparisons. In conclusion, there is no practical advantage to be gained from acquiring very high temporal resolution hepatic DCE-MRI data. Instead the high temporal resolution could be usefully traded for increased spatial resolution or SNR.
authors.affiliation: Department of Radiology, University of Cambridge, Cambridge, UK. Department of Medical Physics, Cambridge University Hospitals, Cambridge, UK.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Gill
authors.forename: Richard T
authors.initials: RT
authors.lastname: Black
authors.forename: David J
authors.initials: DJ
authors.lastname: Bowden
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Priest
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Graves
authors.forename: David J
authors.initials: DJ
authors.lastname: Lomas
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013997:Time Factors
chemical_list: D003287:Contrast Media