title: Clinical Outcomes in Patients with Intermediate Coronary Stenoses: MINIATURE Investigators (Korea MultIceNter TrIal on Long-Term Clinical Outcome According to the Plaque Burden and Treatment Strategy in Lesions with MinimUm Lumen ARea lEss Than 4 mm(2) Using Intravascular Ultrasound).
abstract: OBJECTIVE
  We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy.
  
  
  METHODS
  We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm(2) with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE).
  
  
  RESULTS
  A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034).
  
  
  CONCLUSIONS
  Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm(2) with 50-70% of plaque burden.
authors.affiliation: Division of Cardiology, Chonnam National University School of Medicine, Gwangju, Korea.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Division of Cardiology, Chonnam National University School of Medicine, Gwangju, Korea.
authors.forename: Yun Ha
authors.initials: YH
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Chonnam National University School of Medicine, Gwangju, Korea.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Division of Cardiology, Keimyung University College of Medicine, Dongsan Medical Center, Daegu, Korea.
authors.forename: Chang Wook
authors.initials: CW
authors.lastname: Nam
authors.affiliation: Division of Cardiology, Saint Carollo Hospital, Suncheon, Korea.
authors.forename: Jang Hyun
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Gwangju Veterans Hospital, Gwangju, Korea.
authors.forename: Won Yu
authors.initials: WY
authors.lastname: Kang
authors.affiliation: Division of Cardiology, Chonbuk National University College of Medicine, Jeonju, Korea.
authors.forename: Sang Rok
authors.initials: SR
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.
authors.forename: Sung Yun
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Korea University College of Medicine, Ansan Hospital, Ansan, Korea.
authors.forename: Sang Yeob
authors.initials: SY
authors.lastname: Lim
authors.affiliation: Division of Cardiology, Wonkwang University College of Medicine, Iksan, Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yun
authors.affiliation: Division of Cardiology, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Jung Sun
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Woong Chol
authors.initials: WC
authors.lastname: Kang
authors.affiliation: Division of Cardiology, Jeju National University College of Medicine, Jeju, Korea.
authors.forename: Ki Seok
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Samsung Medical Center, Seoul, Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Chosun University College of Medicine, Gwangju, Korea.
authors.forename: Joong Wha
authors.initials: JW
authors.lastname: Chung
authors.affiliation: Division of Cardiology, KyungHee University Medical Center, Seoul, Korea.
authors.forename: Soo Joong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Chonnam National University School of Medicine, Gwangju, Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: Division of Cardiology, Chonnam National University School of Medicine, Gwangju, Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
keywords: Atherosclerotic plaque; Coronary artery disease; Intravascular ultrasonography