title: The importance of microRNAs in the stroma-breast cancer cell interplay.
abstract: Breast cancer is one of the most diagnosed cancers in women. Despite outstanding progress over the past few years, breast cancer remains the second leading cause of cancer-related death among women. This fact emphasizes the need for improved diagnostic and prognostic markers, as well as improved understanding of cancer environment, including the crosstalk between epithelial and stromal cells. The tumor microenvironment is paramount in breast cancer progression and dissemination. Accumulating evidence indicates that epigenetic phenomena such as microRNAs are extremely important in cancer homeostasis. Through the improved understanding of the molecular mechanisms involved in the microenvironment-mediated promotion of cancer growth and metastasis, novel targets for therapeutic intervention or early diagnosis may be identified.
authors.affiliation: Departement of Morphological Sciences, University of Medicine and Pharmacy "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania The Research Center for Functional Genomics, Biomedicine and Translational Medicine, Cluj Napoca, Romania.
authors.forename: Sergiu
authors.initials: S
authors.lastname: Susman
authors.affiliation: The Research Center for Functional Genomics, Biomedicine and Translational Medicine, Cluj Napoca, Romania Department of Internal Medicine, The Johns Hopkins University Schoolof Medicine, Baltimore, MD, USA Department of Immunology, "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania.
authors.forename: Ciprian
authors.initials: C
authors.lastname: Tomuleasa
authors.affiliation: Department of Radiotherapy, "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Fekete
authors.affiliation: National Cancer Research Center, Istituto Tumori G Paolo II, Bari, Italy.
authors.forename: Brunella
authors.initials: B
authors.lastname: Pilato
authors.affiliation: The Research Center for Functional Genomics, Biomedicine and Translational Medicine, Cluj Napoca, Romania Department of Surgery, "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
authors.affiliation: The Research Center for Functional Genomics, Biomedicine and Translational Medicine, Cluj Napoca, Romania Department of Immunology, "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania Department of Functional Genomic, "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Berindan-Neagoe
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology*; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D035683:MicroRNAs
keywords: Breast cancer; microRNA; tumor microenvironement