title: Early life exposure to fructose and offspring phenotype: implications for long term metabolic homeostasis.
abstract: The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades. As such, interest into the long term outcomes of consuming high levels of fructose has increased significantly, particularly when the exposure is early in life. Epidemiological and experimental evidence has linked fructose consumption to the metabolic syndrome and associated comorbidities-implicating fructose as a potential factor in the obesity epidemic. Yet, despite the widespread consumption of fructose-containing foods and beverages and the rising incidence of maternal obesity, little attention has been paid to the possible adverse effects of maternal fructose consumption on the developing fetus and long term effects on offspring. In this paper we review studies investigating the effects of fructose intake on metabolic outcomes in both mother and offspring using human and experimental studies.
authors.affiliation: The Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, HSC 4H30A, Hamilton, ON, Canada L8S 4K1.
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Sloboda
authors.affiliation: The Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Minglan
authors.initials: M
authors.lastname: Li
authors.affiliation: The Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Rachna
authors.initials: R
authors.lastname: Patel
authors.affiliation: The Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Zoe E
authors.initials: ZE
authors.lastname: Clayton
authors.affiliation: The Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Cassandra
authors.initials: C
authors.lastname: Yap
authors.affiliation: The Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Vickers
mesh_terms: D000818:Animals; D004032:Diet / Q000009:adverse effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005632:Fructose / Q000009:adverse effects*; D006706:Homeostasis; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D008659:Metabolic Diseases / Q000209:etiology*; D024821:Metabolic Syndrome / Q000209:etiology; D009765:Obesity / Q000209:etiology*; D010641:Phenotype; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013549:Sweetening Agents / Q000009:adverse effects*
chemical_list: D013549:Sweetening Agents; D005632:Fructose