title: Effects of colistin on the sensory nerve conduction velocity and F-wave in mice.
abstract: The aim of this study was to examine the changes of sensory nerve conduction velocity (SNCV) and F-wave for colistin-induced peripheral neurotoxicity using a mouse model. Mice were administered with colistin 5, 7.5 and 15 mg/kg/day via a 3-min. intravenous infusion. The sensory nerve conduction velocity (SNCV) and F-wave were measured using the bipolar recording electrodes. The SNCV and F-wave latency changed in a dose- and time-dependent manner. The significant increase of F-wave latency and significant decrease of SNCV appeared on day 3 (p < 0.05 and 0.01, respectively) in the 15 mg/kg/day group, and they were markedly changed on day 7 in the 7.5 mg/kg/day (p < 0.01 and 0.05, respectively) and 15 mg/kg/day groups (both p < 0.01). In addition, F-wave latency also significantly increased on day 7 in the 5 mg/kg/day group (p < 0.05) without any clinical signs. These results indicate that SNCV and F-wave latency were more sensitive in colistin-induced neurotoxicity in mice, which highlights the early monitoring tool of polymyxins neurotoxicity in the clinic.
authors.affiliation: College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Chongshan
authors.initials: C
authors.lastname: Dai
authors.forename: Shusheng
authors.initials: S
authors.lastname: Tang
authors.forename: Jichang
authors.initials: J
authors.lastname: Li
authors.forename: Jiping
authors.initials: J
authors.lastname: Wang
authors.forename: Xilong
authors.initials: X
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D001259:Ataxia / Q000139:chemically induced; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007262:Infusions, Intravenous; D051379:Mice; D018908:Muscle Weakness / Q000139:chemically induced; D009431:Neural Conduction / Q000187:drug effects*; D011984:Sensory Receptor Cells / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin