title: Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes.
abstract: The development of the first redox-free protocol for the Mitsunobu reaction is described. This has been achieved by exploiting triphenylphosphine oxide--the unwanted by-product in the conventional Mitsunobu reaction--as the precursor to the active P(V) coupling reagent. Multinuclear NMR studies are consistent with hydroxyl activation via an alkoxyphosphonium salt.
authors.affiliation: School of Chemistry, University Park, University of Nottingham, Nottingham, UK. ross.denton@nottingham.ac.uk.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Tang
authors.forename: Charlotte
authors.initials: C
authors.lastname: Chapman
authors.forename: Matthew
authors.initials: M
authors.lastname: Whiting
authors.forename: Ross
authors.initials: R
authors.lastname: Denton
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D010753:Phosphoranes / Q000737:chemistry*
chemical_list: D010087:Oxides; D010720:Phosphines; D010753:Phosphoranes; C044646:phosphine