title: Canonical and non-canonical Hedgehog signalling and the control of metabolism.
abstract: Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of one billion people worldwide. These individuals are at higher risk for cancer, stroke, blindness, heart and cardiovascular disease, and to date, have no effective long-term treatment options available. Recent and accumulating evidence has implicated the developmental morphogen Hedgehog and its downstream signalling in metabolic control. Generally thought to be quiescent in adults, Hedgehog is associated with several human cancers, and as such, has already emerged as a therapeutic target in oncology. Here, we attempt to give a comprehensive overview of the key signalling events associated with both canonical and non-canonical Hedgehog signalling, and highlight the increasingly complex regulatory modalities that appear to link Hedgehog and control metabolism. We highlight these key findings and discuss their impact for therapeutic development, cancer and metabolic disease.
authors.affiliation: Department of Epigenetics, Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Teperino
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
authors.forename: Fritz
authors.initials: F
authors.lastname: Aberger
authors.affiliation: Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Harald
authors.initials: H
authors.lastname: Esterbauer
authors.affiliation: Department of Biochemistry and Molecular Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Natalia
authors.initials: N
authors.lastname: Riobo
authors.affiliation: Department of Epigenetics, Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Electronic address: pospisilik@ie-freiburg.mpg.de.
authors.forename: John Andrew
authors.initials: JA
authors.lastname: Pospisilik
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D053823:Hedgehog Proteins
keywords: Cancer; Development; Metabolism; Non-canonical Hedgehog signalling