title: ALK negative inflammatory myofibroblastic tumor of the orbit: a masquerading entity.
abstract: Inflammatory myofibroblastic tumor is a biologically distinct neoplasm of intermediate grade, which can affect every possible tissue of the human body. It is a 'masquerading tumor' as the presenting complaints vary with the affected site. Occurrence of this tumor as an orbital mass is rare and is challenging for both the clinician as well as the pathologist, due to a varied number of lesions sharing a similar picture clinically and histologically. We discuss a rare case of inflammatory myofibroblastic tumor presenting as an orbital mass and the importance of immunohistochemistry in arriving at the diagnosis, which helps dictate the treatment and prognosis of the patient.
authors.forename: Vibha
authors.initials: V
authors.lastname: Dutta
authors.forename: Madakshira Gopal
authors.initials: MG
authors.lastname: Manoj
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Malik
authors.forename: Poninder
authors.initials: P
authors.lastname: Kumar
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000201:enzymology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases