title: Functional dyspepsia symptom resolution after Helicobacter pylori eradication with two different regimens.
abstract: BACKGROUND
  Functional dyspepsia (FD), a common functional gastrointestinal disorder, has a complex underlying pathophysiological mechanism that involves changes in gastric motility, visceral hypersensitivity, genetic susceptibility, psychosocial factors and Helicobacter pylori infection. Although there are several H. pylori eradication treatments, there is not enough data that compare these different eradication treatments for FD symptom resolution. Most previous studies have focused on the eradication rates of H. pylori rather than symptom relief in FD.
  
  
  OBJECTIVE
  In this regard, we aimed to clarify if there is any difference between standard triple therapy and sequential therapy for symptom resolution of FD patients with H. pylori, using a validated health quality index.
  
  
  METHODS
  A total of 194 patients were included in this study. The patients were randomly assigned to receive standard triple therapy (omeprazole, amoxicilline and clarithromycin for 14 days) or sequential therapy (omeprazole plus amoxicilline for 7 days and omeprazole twice daily, metronidazole and clarithromycin for a subsequent 7 days) by a blind physician for H. pylori status. Outcome measures were based on symptomatic improvement at 12 months using a validated measure of subjective well-being (Gastrointestinal Symptom Rating Scale - GSRS).
  
  
  RESULTS
  We observed significant symptom resolution at 12 months in both treatment groups. On the other hand, there was no difference between the sequential or standard triple therapy groups regarding the alleviation of symptoms.
  
  
  CONCLUSIONS
  No difference for symptom relief exists between sequential and triple therapy in patients with FD.
authors.affiliation: Ankara Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sarikaya
authors.affiliation: Ankara Research Hospital, Ankara, Turkey.
authors.forename: Zeynal
authors.initials: Z
authors.lastname: Dogan
authors.affiliation: Ankara Research Hospital, Ankara, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Ergül
authors.affiliation: Ankara Research Hospital, Ankara, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Filik
keywords: Helicobacter pylori; dyspepsia; triple therapy