title: Cadherin adhesion controlled by cortical actin dynamics.
abstract: Cadherin-containing cell-cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of cadherin molecules and increase their concentration at junctions.
authors.affiliation: Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: de Rooij
mesh_terms: D000199:Actins / Q000378:metabolism*; D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism*; D002448:Cell Adhesion; D040542:Mechanotransduction, Cellular; D012510:Sarcoma 180 / Q000378:metabolism*
chemical_list: D000199:Actins; D015820:Cadherins