title: Clinical potential of bevacizumab in the treatment of metastatic and locally advanced cervical cancer: current evidence.
abstract: The addition of bevacizumab to established therapies for metastatic and locally advanced cervical cancer is an area of evolving research and a potential strategy toward improving historically suboptimal outcomes for women with advanced disease. Bevacizumab, when added to first-line chemotherapy, has now been shown to improve overall survival among women with metastatic cervical cancer, and recent Phase II data suggests it is safe and effective for patients with locally advanced disease treated with curative intent. Here we review the rationale and current evidence for bevacizumab in clinical practice, with an emphasis on the emerging role of bevacizumab in the treatment of metastatic and locally advanced cervical cancer.
authors.affiliation: Department of Radiation Oncology, University of Colorado, Denver, CO, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Jackson
authors.affiliation: Department of Radiation Oncology, University of Colorado, Denver, CO, USA.
authors.forename: Chad G
authors.initials: CG
authors.lastname: Rusthoven
authors.affiliation: Department of Radiation Oncology, University of Colorado, Denver, CO, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Fisher
authors.affiliation: Department of Radiation Oncology, University of Colorado, Denver, CO, USA.
authors.forename: Tracey E
authors.initials: TE
authors.lastname: Schefter
keywords: Avastin®; advanced cervical cancer; bevacizumab; metastatic cervical cancer