title: Growth and differentiation of a long bone in limb development, repair and regeneration.
abstract: Repair from traumatic bone fracture is a complex process that includes mechanisms of bone development and bone homeostasis. Thus, elucidation of the cellular/molecular basis of bone formation in skeletal development would provide valuable information on fracture repair and would lead to successful skeletal regeneration after limb amputation, which never occurs in mammals. Elucidation of the basis of epimorphic limb regeneration in amphibians would also provide insights into skeletal regeneration in mammals, since the epimorphic regeneration enables an amputated limb to re-develop the three-dimensional structure of bones. In the processes of bone development, repair and regeneration, growth of the bone is achieved through several events including not only cell proliferation but also aggregation of mesenchymal cells, enlargement of cells, deposition and accumulation of extracellular matrix, and bone remodeling.
authors.affiliation: Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama 6-3, Aoba-ku, Sendai, 980-8578, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Egawa
authors.forename: Shinichirou
authors.initials: S
authors.lastname: Miura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Endo
authors.forename: Koji
authors.initials: K
authors.lastname: Tamura
mesh_terms: D000818:Animals; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D005121:Extremities / Q000254:growth & development; D050723:Fractures, Bone / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000254:growth & development* / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis
keywords: bone; differentiation; fracture; growth; regeneration