title: Blood lipid profile and BMI-Z-score in adolescents with hyperuricemia.
abstract: BACKGROUND
  Numerous studies have demonstrated that elevated serum uric acid concentration (SUA) is correlated with lipid profile in hypertensive or obese patients. However, the relationship between serum uric acid levels and lipid profile in non-obese late adolescent population was not examined before.
  
  
  OBJECTIVE
  In this study we decided to assess the potential relationship between SUA and lipid profile, according to gender in adolescents with HU.
  
  
  METHODS
  The study group comprises 607 Polish adolescents (474 males, 133 females) with HU. Retrospective analysis included demographic, clinical, and laboratory data. Lipid profile was assessed including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol to HDL-C ratio (TC/HDL-C).
  
  
  RESULTS
  In the examined group 187/607 (31%) of teenagers were diagnosed with metabolic syndrome (MetS). Median BMI-Z-score was 1.11 Q1-Q3: (-0.02-2.03) and both females and males in the upper tertile of SUA had statistically significant higher BMI-Z-score. The males in the upper tertile of serum uric acid levels also had higher values of TG and lower of HDL-C. In females, we have not found significant differences in lipid profile. Multiple regression analyses indicated that male gender, BMI-Z-score, and presence of hypertension correlated significantly with serum uric acid concentration.
  
  
  CONCLUSIONS
  In summary, the results of our study confirm higher prevalence of hyperuricemia in males when compared to females and a stronger association of HU with BMI-Z-score and lipid profile in male adolescents. Nevertheless, multiple regression does not confirm the independent association of SUA with lipid profile.
authors.affiliation: Department of Health and Social Sciences, Pope John Paul II State School of Higher Education in Biała Podlaska, 95/97 Sidorska Street, 21-500, Biała Podlaska, Poland, marian.stelmach@me.com.
authors.forename: M J
authors.initials: MJ
authors.lastname: Stelmach
authors.forename: N
authors.initials: N
authors.lastname: Wasilewska
authors.forename: L I
authors.initials: LI
authors.lastname: Wicklund-Liland
authors.forename: A
authors.initials: A
authors.lastname: Wasilewska
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D033461:Hyperuricemia / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis*; D012189:Retrospective Studies; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D014527:Uric Acid