title: Cache-Oblivious parallel SIMD Viterbi decoding for sequence search in HMMER.
abstract: BACKGROUND
  HMMER is a commonly used bioinformatics tool based on Hidden Markov Models (HMMs) to analyze and process biological sequences. One of its main homology engines is based on the Viterbi decoding algorithm, which was already highly parallelized and optimized using Farrar's striped processing pattern with Intel SSE2 instruction set extension.
  
  
  RESULTS
  A new SIMD vectorization of the Viterbi decoding algorithm is proposed, based on an SSE2 inter-task parallelization approach similar to the DNA alignment algorithm proposed by Rognes. Besides this alternative vectorization scheme, the proposed implementation also introduces a new partitioning of the Markov model that allows a significantly more efficient exploitation of the cache locality. Such optimization, together with an improved loading of the emission scores, allows the achievement of a constant processing throughput, regardless of the innermost-cache size and of the dimension of the considered model.
  
  
  CONCLUSIONS
  The proposed optimized vectorization of the Viterbi decoding algorithm was extensively evaluated and compared with the HMMER3 decoder to process DNA and protein datasets, proving to be a rather competitive alternative implementation. Being always faster than the already highly optimized ViterbiFilter implementation of HMMER3, the proposed Cache-Oblivious Parallel SIMD Viterbi (COPS) implementation provides a constant throughput and offers a processing speedup as high as two times faster, depending on the model's size.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ferreira
authors.forename: Nuno
authors.initials: N
authors.lastname: Roma
authors.affiliation: Instituto Superior Técnico, Universidade de Lisboa, Av, Rovisco Pais, 1049-001 Lisboa, Portugal. lsr@kdbio.inesc-id.pt.
authors.forename: Luis M S
authors.initials: LM
authors.lastname: Russo
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D030562:Databases, Protein; D006801:Humans; D008390:Markov Chains; D016415:Sequence Alignment; D017421:Sequence Analysis / Q000379:methods*