title: Different immunology mechanisms of Phellinus igniarius in inhibiting growth of liver cancer and melanoma cells.
abstract: To assess inhibition mechanisms of a Phellinus igniarius (PI) extract on cancer, C57BL/6 mice were orally treated with PI extractive after or before implanting H22 (hepatocellular carcinoma ) or B16 (melanoma) cells. Mice were orally gavaged with different doses of PI for 36 days 24h after introduction of H22 or B16 cells. Mice in another group were orally treated as above daily for 42 days and implanted with H22 cells on day 7. Then the T lymphocyte, antibody, cytokine, LAK, NK cell activity in spleen, tumor cell apoptosis status and tumor inhibition in related organs, as well as the expression of iNOS and PCNA in tumor tissue were examined. The PI extract could improve animal immunity as well as inhibit cancer cell growth and metastasis with a dose-response relationship. Notably, PI's regulation with the two kinds of tumor appeared to occur in different ways, since the antibody profile and tumor metastasis demonstrated variation between animals implanted with hepatocellular carcinoma and melanoma cells.
authors.affiliation: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China E-mail : chehuilian@cau.edu.cn.
authors.forename: Cui
authors.initials: C
authors.lastname: Zhou
authors.forename: Song-Song
authors.initials: SS
authors.lastname: Jiang
authors.forename: Cui-Yan
authors.initials: CY
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Hui-Lian
authors.initials: HL
authors.lastname: Che
mesh_terms: D000363:Agaricales / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000187:drug effects* / Q000276:immunology; D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor / Q000637:transplantation; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects* / Q000276:immunology; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008113:Liver Neoplasms; D008546:Melanoma, Experimental; D051379:Mice; D008810:Mice, Inbred C57BL; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000276:immunology; D018809:Proliferating Cell Nuclear Antigen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D023041:Xenograft Model Antitumor Assays
chemical_list: D000906:Antibodies; D016207:Cytokines; D018809:Proliferating Cell Nuclear Antigen; D052247:Nitric Oxide Synthase Type II