title: [Survival of patients with biopsy-proven idiopathic pulmonary fibrosis: Chilean National Thorax Institute experience].
abstract: BACKGROUND
  Idiopathic Pulmonary Fibrosis (IPF) is the most prevalent of all interstitial lung diseases. The usual underlying pathological picture is an interstitial pneumonia (UIP).
  
  
  OBJECTIVE
  To describe the evolution of a Chilean cohort of patients with IPF.
  
  
  METHODS
  Patients with the disease were identified at the pathology registry of National Institute of Thoracic Diseases, Santiago, Chile. Patients were included if they had surgical biopsy of UIP and compatible clinical and radiological characteristics. The medical records of included patients were reviewed, recording clinical information and lung function test results. Survival was analyzed obtaining death records from the Chilean National Identification Service.
  
  
  RESULTS
  Data from 142 patients with a mean age of 58 years (42% men), were analyzed. Mean initial lung function showed a forced vital capacity (FVC) of 73%, carbon monoxide diffusing capacity (DLCO) of 57% and a distance covered in 6-minute walk (6MWT) of 95% of expected normal values. The median survival was 80 months. Predictors of survival were a DLCO of less than 40% and an oxygen saturation at the end of the 6MWT of less than 89%.
  
  
  CONCLUSIONS
  Survival in this group of patients was higher than the figures reported elsewhere. DLCO and the fall of oxygen saturation after walking were predictors of mortality, as previously described in other populations.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Salinas
authors.forename: Matías
authors.initials: M
authors.lastname: Florenzano
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sabbagh
authors.forename: Manuel
authors.initials: M
authors.lastname: Meneses
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernández
authors.forename: Alfredo
authors.initials: A
authors.lastname: Jalilie
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rodríguez
authors.forename: Gabriel
authors.initials: G
authors.lastname: Cavada
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Undurraga
mesh_terms: D001706:Biopsy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000401:mortality* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D016019:Survival Analysis