title: High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenase-deficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of Plasmodium vivax malaria.
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil marli.maciel@uol.com.br.
authors.forename: Marli S
authors.initials: MS
authors.lastname: Santana
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Wuelton M
authors.initials: WM
authors.lastname: Monteiro
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Mônica R F
authors.initials: MR
authors.lastname: Costa
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Vanderson S
authors.initials: VS
authors.lastname: Sampaio
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Marcelo A M
authors.initials: MA
authors.lastname: Brito
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Marcus V G
authors.initials: MV
authors.lastname: Lacerda
authors.affiliation: Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Maria G C
authors.initials: MG
authors.lastname: Alecrim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials; D001786:Blood Glucose / Q000378:metabolism*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D000075202:Contraindications; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D005215:Fasting; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D006801:Humans; D016780:Malaria, Vivax / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax; D015995:Prevalence; D011319:Primaquine
chemical_list: D000962:Antimalarials; D001786:Blood Glucose; D011319:Primaquine