title: Non-Hodgkin's thyroid lymphoma associated with Hashimoto's thyroiditis.
abstract: We report two cases of thyroid lymphoma. First was of a 54-year-old lady who presented with a 10 year history of goiter. Examination revealed an enlarged thyroid gland extending sub-sternally, with no palpable lymph nodes. She had been on thyroxine for 4 months, due to a high TSH with positive antibodies. Fine needle aspiration cytology of thyroid showed Hashimoto thyroiditis (HT). A total thyroidectomy was done because of pressure symptoms. Histopathology revealed HT in right lobe and Diffuse Large B-cell Non-Hodgkin's lymphoma (DLBCL) in left lobe. Second case was of a 30 year-old man who presented with dyspnoea secondary to rapidly enlarging thyroid. On examination, thyroid was diffusely enlarged together with palpable lymph nodes. His TSH was elevated & Anti-TPO antibodies were positive suggesting an autoimmune etiology. Ultrasound showed, an ill-defined heterogeneous mass in the left lobe of thyroid gland with multiple enlarged lymph nodes. Ultrasound guided thyroid core biopsy revealed DLBCL.
authors.forename: Tamseela
authors.initials: T
authors.lastname: Ahmed
authors.forename: Naila
authors.initials: N
authors.lastname: Kayani
authors.forename: Zubair
authors.initials: Z
authors.lastname: Ahmad
authors.forename: Muhammad Naeemul
authors.initials: MN
authors.lastname: Haque
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000601:surgery; D013965:Thyroidectomy