title: Biomimetic synthesis and antioxidant evaluation of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate].
abstract: Phenolic compounds present in extra virgin olive oil have attracted considerable recent attention. Many of them, show specific anti-inflammatory and anti-tumor activities. In this work we describe the biomimetic synthesis of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate], starting from natural demethyloleuropein present in olive tissues. A comparison between 3,4-DHPEA-EDA (6) and oleuropein (1), oleuropein aglycone (4) and hydroxytyrosol ORACFL values was undertaken.
authors.affiliation: Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Nardi
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viele Europa - Campus Universitario "S. Venuta" - Loc., Germaneto 88100, CZ, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Bonacci
authors.affiliation: Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: De Luca
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viele Europa - Campus Universitario "S. Venuta" - Loc., Germaneto 88100, CZ, Italy.
authors.forename: Jessica
authors.initials: J
authors.lastname: Maiuolo
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viele Europa - Campus Universitario "S. Venuta" - Loc., Germaneto 88100, CZ, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Oliverio
authors.affiliation: Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende, CS, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sindona
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viele Europa - Campus Universitario "S. Venuta" - Loc., Germaneto 88100, CZ, Italy. Electronic address: procopio@unicz.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Procopio
mesh_terms: D000893:Anti-Inflammatory Agents; D000975:Antioxidants / Q000737:chemistry*; D032701:Biomimetics / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D000069463:Olive Oil; D010636:Phenols / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*
chemical_list: C547883:3,4-dihydroxyphenylethanol-elenolic acid dialdehyde; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; D011714:Pyrans
keywords: 3,4-DHPEA-EDA; Anti-inflammatory; Demethyloleuropein; Lanthanoid triflates; Lewis acid catalyst