title: Indispensable value of clinical trials in the modernization of traditional Chinese medicine: 12 years' experience at CUHK and future perspectives.
abstract: The last decade has seen a wealth of information reporting the beneficial effects of Chinese herbal medicines. While a lot more studies were done using in vitro and in vivo research platforms, much fewer investigations were conducted according to evidence-based requirements in clinical settings. The Institute of Chinese Medicine at the Chinese University of Hong Kong (CUHK) has had the opportunity to collaborate with clinicians over the years to initiate and conduct dozens of clinical trials investigating and verifying the therapeutic values of Chinese herbs in selected disease conditions. Of the many disorders, we chose to focus on those that are known for their difficulties achieving perfect results with conventional treatment methods. Examples include non-healing ulcers, allergic conditions, degenerative diseases and cancer. Protective effects of the herbs in such chronic diseases as coronary artery disease and osteoporosis were also part of our focus. Even in healthy individuals and those recovering from chemotherapy, Chinese herbs could help with the immune system and were studied in our clinical trials as well. This paper aims to highlight the important findings from these clinical studies while at the same time, stressing the indispensable value of clinical trials in modernizing the use of Chinese herbs in present-day medicine.
authors.affiliation: Institute of Chinese Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
authors.forename: Willmann
authors.initials: W
authors.lastname: Liang
authors.forename: David T
authors.initials: DT
authors.lastname: Yew
authors.forename: Kam Lun
authors.initials: KL
authors.lastname: Hon
authors.forename: Chun Kwok
authors.initials: CK
authors.lastname: Wong
authors.forename: Timothy C Y
authors.initials: TC
authors.lastname: Kwok
authors.forename: Ping Chung
authors.initials: PC
authors.lastname: Leung
mesh_terms: D001249:Asthma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000517:prevention & control; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy*; D017719:Diabetic Foot / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D005544:Forecasting; D006723:Hong Kong; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000639:trends*; D009369:Neoplasms / Q000188:drug therapy; D010024:Osteoporosis / Q000517:prevention & control; D008517:Phytotherapy; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology; D012220:Rhinitis / Q000188:drug therapy; D012577:Schools, Medical
chemical_list: D004365:Drugs, Chinese Herbal