title: Surgical management of corneal limbal dermoids: retrospective study of different techniques and use of Mitomycin C.
abstract: OBJECTIVE
  We retrospectively studied the efficacy and safety of different surgical approaches to treating pediatric limbal dermoids with regard to intra and postoperative complications.
  
  
  METHODS
  The data of 12 consecutive patients (14 eyes), who underwent monocentric surgery of a limbal demoid in the past 9 years, were retrospectively analyzed for intra and postoperative complications. Group one consists of eleven eyes: seven eyes with a bare-sclera deep lamellar excision of the dermoid and four eyes with an additional amniotic membrane transplantation subsequent to excision. Group two consists of three eyes: two eyes treated with Mitomycin C 0.02% over 2 min following the excision, and one eye treated with Mitomycin C and amniotic membrane transplantation after removal of the dermoid. Follow-up ranged from 2 to 53 months (median 17 months).
  
  
  RESULTS
  Intraoperative complications did not occur in any of the patients. Postoperatively, all patients showed corneal reepithelialization within a week. Limbal stem cell deficiency with a pseudopterygium developed in four eyes, one treated with bare-sclera excision and the others with amniotic membrane transplantation. One pseudopterygium had to be removed surgically because of visual acuity deterioration. Not a single eye treated with Mitomycin C developed a pseudopterygium.
  
  
  CONCLUSIONS
  The transplantation of amniotic membrane following removal of a limbal dermoid cannot prevent the occurrence of a pseudopterygium. However, the use of Mitomycin C seems to have a protective effect.
authors.affiliation: Department of Ophthalmology, University Eye Hospital Freiburg, Freiburg im Breisgau, Germany.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lang
authors.affiliation: Department of Ophthalmology, University Eye Hospital Freiburg, Freiburg im Breisgau, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Böhringer
authors.affiliation: Department of Ophthalmology, University Eye Hospital Freiburg, Freiburg im Breisgau, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Reinhard
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage*; D000650:Amnion / Q000637:transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003316:Corneal Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003884:Dermoid Cyst / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D005134:Eye Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D016850:Limbus Corneae / Q000473:pathology*; D008297:Male; D033401:Microscopy, Acoustic; D016685:Mitomycin / Q000008:administration & dosage*; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin