title: Roles of olfactory system dysfunction in depression.
abstract: The olfactory system is involved in sensory functions, emotional regulation and memory formation. Olfactory bulbectomy in rat has been employed as an animal model of depression for antidepressant discovery studies for many years. Olfaction is impaired in animals suffering from chronic stress, and patients with clinical depression were reported to have decreased olfactory function. It is believed that the neurobiological bases of depression might include dysfunction in the olfactory system. Further, brain stimulation, including nasal based drug delivery could provide novel therapies for management of depression.
authors.affiliation: School of Psychology, Nanjing Normal University, China. Electronic address: ytf0707@126.com.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
authors.affiliation: Department of Psychology, American University, United States.
authors.forename: Burton M
authors.initials: BM
authors.lastname: Slotnick
mesh_terms: D000818:Animals; D003866:Depressive Disorder / Q000503:physiopathology* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D055495:Neurogenesis / Q000502:physiology; D009830:Olfactory Bulb / Q000503:physiopathology* / Q000601:surgery; D012903:Smell / Q000502:physiology*
keywords: Antidepressant; Depression; Limbic system; Neurogenesis; Olfactory bulbectomy