title: Nine new and five known polyketides derived from a deep sea-sourced Aspergillus sp. 16-02-1.
abstract: Nine new C9 polyketides, named aspiketolactonol (1), aspilactonols A-F (2-7), aspyronol (9) and epiaspinonediol (11), were isolated together with five known polyketides, (S)-2-(2'-hydroxyethyl)-4-methyl-γ-butyrolactone (8), dihydroaspyrone (10), aspinotriol A (12), aspinotriol B (13) and chaetoquadrin F (14), from the secondary metabolites of an Aspergillus sp. 16-02-1 that was isolated from a deep-sea sediment sample. Structures of the new compounds, including their absolute configurations, were determined by spectroscopic methods, especially the 2D NMR, circular dichroism (CD), Mo2-induced CD and Mosher's 1H NMR analyses. Compound 8 was isolated from natural sources for the first time, and the possible biosynthetic pathways for 1-14 were also proposed and discussed. Compounds 1-14 inhibited human cancer cell lines, K562, HL-60, HeLa and BGC-823, to varying extents.
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. chenxiuwen2010@126.com.
authors.forename: Xiu-Wen
authors.initials: XW
authors.lastname: Chen
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. sdrlcw@126.com.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Li
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. cuicb@126.com.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Cui
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. huawei0917@outlook.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Hua
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. zhutj@ouc.edu.cn.
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. guqianq@ouc.edu.cn.
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000302:isolation & purification / Q000378:metabolism*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D019015:Geologic Sediments / Q000382:microbiology; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D061065:Polyketides