title: Prediction of temperature and damage in an irradiated human eye-Utilization of a detailed computer model which includes a vectorial blood stream in the choroid.
abstract: The work presented here describes the development and use of a three-dimensional thermo-dynamic model of the human eye for the prediction of temperatures and damage thresholds under irradiation. This model takes into account the blood flow by the implementation of a vectorial blood stream in the choroid and also uses the actual physiological extensions and tissue parameters of the eye. Furthermore it considers evaporation, radiation and convection at the cornea as well as the eye lid. The predicted temperatures were successfully validated against existing eye models in terms of corneal and global thermal behaviour. The model׳s predictions were additionally checked for consistency with in-vivo temperature measurements of the cornea, the irradiated retina and its damage thresholds. These thresholds were calculated from the retinal temperatures using the Arrhenius integral. Hence the model can be used to predict the temperature increase and irradiation hazard within the human eye as long as the absorption values and the Arrhenius coefficients are known and the damage mechanism is in the thermal regime.
authors.affiliation: FZI, Forschungszentrum Informatik, Haid-und Neu-Straße 10-14, 76131 Karlsruhe, Germany. Electronic address: Heussner@fzi.de.
authors.forename: Nico
authors.initials: N
authors.lastname: Heussner
authors.affiliation: Karlsruhe Institute of Technology, Engesserstraße 5, 76131 Karlsruhe, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Holl
authors.affiliation: Karlsruhe Institute of Technology, Engesserstraße 5, 76131 Karlsruhe, Germany.
authors.forename: Timo
authors.initials: T
authors.lastname: Nowak
authors.affiliation: Karlsruhe Institute of Technology, Engesserstraße 5, 76131 Karlsruhe, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Beuth
authors.affiliation: Centre for Ophthalmology, University Eye Hospital, Schleichstraße 12, 72076 Tübingen, Germany.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Spitzer
authors.affiliation: FZI, Forschungszentrum Informatik, Haid-und Neu-Straße 10-14, 76131 Karlsruhe, Germany; Karlsruhe Institute of Technology, Engesserstraße 5, 76131 Karlsruhe, Germany.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Stork
mesh_terms: D001783:Blood Flow Velocity; D003315:Cornea / Q000098:blood supply* / Q000601:surgery; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008954:Models, Biological; D012160:Retina; D013816:Thermodynamics
keywords: Arrhenius integral; Damage prediction; Eye model; Ocular blood flow; Retinal damage; Temperature prediction; Vectorial blood stream