title: Experimental and theoretical perspectives of the Noyori-Ikariya asymmetric transfer hydrogenation of imines.
abstract: The asymmetric transfer hydrogenation (ATH) of imines catalyzed by the Noyori-Ikariya [RuCl(η6-arene)(N-arylsulfonyl-DPEN)] (DPEN=1,2-diphenylethylene-1,2-diamine) half-sandwich complexes is a research topic that is still being intensively developed. This article focuses on selected aspects of this catalytic system. First, a great deal of attention is devoted to the N-arylsulfonyl moiety of the catalysts in terms of its interaction with protonated imines (substrates) and amines (components of the hydrogen-donor mixture). The second part is oriented toward the role of the η6-coordinated arene. The final part concerns the imine substrate structural modifications and their importance in connection with ATH. Throughout the text, the summary of known findings is complemented with newly-presented ones, which have been approached both experimentally and computationally.
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Václavík
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Sot
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Pecháček
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic.
authors.forename: Beáta
authors.initials: B
authors.lastname: Vilhanová
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic.
authors.forename: Ondřej
authors.initials: O
authors.lastname: Matuška
authors.affiliation: Laboratory of Molecular Structure Characterization, Institute of Microbiology, v.v.i., Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Kuzma
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic. kacerp@vscht.cz.
authors.forename: Petr
authors.initials: P
authors.lastname: Kačer
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007097:Imines; D012428:Ruthenium