title: Evaluation of gabapentin in management of hot flushes in postmenopausal women.
abstract: This study was conducted to assess the efficacy of gabapentin in controlling hot flushes in postmenopausal women. Fifty postmenopausal patients with hot flushes were randomized in two groups, one receiving gabapentin 900 mg daily along with calcium and another group receiving calcium alone. Frequency, duration and severity of hot flushes were noted and a composite score was calculated. There was around an 80% reduction in composite score in the gabapentin group at 3 and 6 months; significantly more than the placebo group. Gabapentin has a two-fold better response than placebo in reducing hot flushes with the relief starting from the first month and maximum effect at 3 months.
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi nutan.agarwal1@gmail.com nutan_agarwal@yahoo.com.
authors.forename: Nutan
authors.initials: N
authors.lastname: Agarwal
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Smita
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Alka
authors.initials: A
authors.lastname: Kriplani
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Neerja
authors.initials: N
authors.lastname: Bhatla
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Nilanchali
authors.initials: N
authors.lastname: Singh
keywords: Hot flushes; gabapentin; postmenopausal