title: Changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic protein.
abstract: Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used astrocytes isolated from GFAP null mice. We find that selected astrocytic changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape, and cell death for solutes, and proliferation for films.
authors.affiliation: Department of Neurobiology, University of Alabama , Birmingham, Alabama 35294, United States.
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Gottipati
authors.forename: Elena
authors.initials: E
authors.lastname: Bekyarova
authors.forename: Michael
authors.initials: M
authors.lastname: Brenner
authors.forename: Robert C
authors.initials: RC
authors.lastname: Haddon
authors.forename: Vladimir
authors.initials: V
authors.lastname: Parpura
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000378:metabolism; D049109:Cell Proliferation; D048430:Cell Shape; D002478:Cells, Cultured; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D037742:Nanotubes, Carbon