title: Self-induced stereoselective in situ trifluoromethylation: preparation of spiro[indoline-3,3'-quinoline] via palladium-catalyzed cascade reaction.
abstract: An efficient method to prepare 1'H-spiro[indoline-3,3'-quinoline]-2',4'-diones and their trifluoromethylated products was developed via a palladium-catalyzed Sonogashira coupling/Wacker-type oxypalladation/cyclization cascade reaction. The amount of water in the reaction system played an important role in the in situ trifluoromethylation reaction, and the trifluoromethylation exhibited excellent molecular self-induced stereoselectivity.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, China.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Song
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Liu
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Wang