title: [Cyanidin-3-glucoside attenuates body weight gain, serum lipid concentrations and insulin resistance in high-fat diet-induced obese rats].
abstract: OBJECTIVE
  Cyanidin-3-glucoside (C3G) is the main active ingredient of anthocyanidin. This study aimed to evaluate the effects of C3G on body weight gain, visceral adiposity, lipid profiles and insulin resistance in high-fat diet-induced obese rats.
  
  
  METHODS
  Thirty male Sprague-Dawley rats were randomly divided into a control group (n=8) and a high fat diet group (n=22), and were fed with standard diet or high fat diet. Five weeks later, 17 high-fat diet-induced obese rats were randomly given C3G [100 mg/(kg·d)] or normal saline via intragastric administration for 5 weeks. Five weeks later, body weight, visceral adiposity and food intake were measured. Blood samples were collected for detecting fasting glucose, serum insulin, lipid profiles and adiponectin. Insulin resistance index, atherosclerosis index and average feed efficiency ratio were calculated.
  
  
  RESULTS
  C3G supplementation markedly decreased body weight, visceral adiposity, average feed efficiency ratio, triglyceride, total cholesterol, low density lipoprotein cholesterol, fasting glucose, serum insulin, insulin resistance index and atherosclerosis index in high-fat diet-induced obese rats. C3G supplementation normalized serum adiponectin and high density lipoprotein cholesterol levels in high-fat diet-induced obese rats.
  
  
  CONCLUSIONS
  Cyanidin-3-glucoside can reduce body weight gain, and attenuate obesity-associated dyslipidemia and insulin resistance in high-fat diet-fed rats via up-regulating serum adiponectin level.
authors.affiliation: Department of Pediatrics, First Hospital Affiliated to Dalian Medical University, Dalian, Liaoning 116011, China. main8251@163.com.
authors.forename: Ren-Qiang
authors.initials: RQ
authors.lastname: Yu
authors.forename: Xiao-You
authors.initials: XY
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Lu-Yi
authors.initials: LY
authors.lastname: Ma
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D059305:Diet, High-Fat; D005960:Glucosides / Q000494:pharmacology*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000872:Anthocyanins; D001786:Blood Glucose; D005960:Glucosides; D008055:Lipids; C462279:cyanidin-3-O-beta-glucopyranoside