title: A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts.
abstract: BACKGROUND
  Alternanthera sessilis is used by folk medicinal practitioners of Bangladesh for alleviation of severe pain. The objective of this study was to scientifically analyze the analgesic (non-narcotic) property of aerial parts of the plant along with antihyperglycemic activity.
  
  
  METHODS
  Antihyperglycemic activity was measured by oral glucose tolerance tests. Analgesic (non-narcotic) activity was determined by observed decreases in abdominal writhings in intraperitoneally administered acetic acid-induced pain model in mice.
  
  
  RESULTS
  Administration of methanol extract of aerial parts led to dose-dependent and significant reductions in blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, the extract reduced blood sugar levels by 22.9, 30.7, 45.4 and 46.1%, respectively compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 48.9%. In analgesic activity tests, the extract at the above four doses reduced the number of abdominal writhings by 27.6, 37.9, 41.4, and 44.8%, respectively. A standard analgesic drug, aspirin, reduced the number of writhings by 31.0 and 51.7%, respectively, when administered at doses of 200 and 400 mg per kg body weight.
  
  
  CONCLUSIONS
  The results validate the folk medicinal use of the plant to alleviate pain. At the same time, the antihyperglycemic activity result suggests that the plant may be a potential source for blood sugar lowering drug(s).
authors.forename: Ahamed Ismail
authors.initials: AI
authors.lastname: Hossain
authors.forename: Mohammad
authors.initials: M
authors.lastname: Faisal
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Rahman
authors.forename: Rownak
authors.initials: R
authors.lastname: Jahan
authors.affiliation: Department of Biotechnology and Genetic Engineering, University of Development Alternative, Dhanmondi, Dhaka 1209, Bangladesh. rahamatm@hotmail.com.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rahmatullah
mesh_terms: D019342:Acetic Acid; D027703:Amaranthaceae / Q000737:chemistry*; D000700:Analgesics / Q000032:analysis* / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001459:Bangladesh; D001786:Blood Glucose / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005947:Glucose; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000700:Analgesics; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005947:Glucose; D019342:Acetic Acid; D001241:Aspirin; D005905:Glyburide