title: Granular cell tumor of the oral cavity; a case series including a case of metachronous occurrence in the tongue and the lung.
abstract: The granular cell tumor (GCT) is a rare, benign tumor that most commonly occurs in the oral cavity, particularly in the anterior part of the tongue. In this study the experience with 16 patients with a GCT observed in a single Institution will be discussed. Although no radicality has been obtained in most cases, recurrences are rare. In one patient, a recurrence was noted four years after excision of the primary. In the same patient a pulmonary lesion occurred five years after excision of the recurrence in the oral cavity, most likely representing an example of metachronous occurrence and not a distant metastasis. Since recurrences and metachronous lesions are rare, as are distant metastases, routine follow-up does not seem warranted in patients treated for a granular cell tumor of the oral cavity.
authors.affiliation: VU university medical center, Dept. of Oral and Maxillofacial Surgery/Oral Pathology, P.O.Box 7057, 1007MB, Amsterdam, The Netherlands, i.vanderwaal@vumc.nl.
authors.forename: Sander
authors.initials: S
authors.lastname: van de Loo
authors.forename: Erik
authors.initials: E
authors.lastname: Thunnissen
authors.forename: Pieter
authors.initials: P
authors.lastname: Postmus
authors.forename: Isaäc
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology; D055815:Young Adult