title: Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures.
abstract: OBJECTIVE
  The relationship between epilepsy and inflammation is known, and it has been reported that there is an increase in cyclooxygenase (COX) levels in epilepsy. We aim to reveal the anticonvulsant effects of dexketoprofen in pentylenetetrazol (PTZ)-induced seizures in rats.
  
  
  METHODS
  Forty-eight male Sprague-Dawley rats, 24 of them for EEG recording and 24 of them are for behavioral studies, were randomly divided in two groups: Group A for EEG recordings and Group B for behavioral assessment. A weight of 70 mg/kg PTZ was used for behavioral studies after dexketoprofen administration. Thirty-five milligrams per kilogram PTZ were used for EEG recording after dexketoprofen administration. The electrodes were implanted on dura over the left frontal cortex and the reference electrode was implanted over the cerebellum for EEG recording. The Racine convulsion scale (RCS), first myoclonic jerk (FMJ) onset time, and spike percentages were evaluated between the two groups.
  
  
  RESULTS
  There was a significant (P< 0·05) difference between the RCS, FMJ onset time (P< 0·001), and spike percentage (P< 0·05) between the groups (Group 2 compared with Groups 3 and 4).
  
  
  CONCLUSIONS
  Dexketoprofen has an antiepileptic feature and this effect increases as the dosage increases, however it is currently unknown through which mechanism this drug shows its anticonvulsant effect. Dexketoprofen, in the group of NSAIDs, shows an anticonvulsant effect on PTZ-induced epilepsy model. This study suggests that dexketoprofen can preferably be used with NSAIDs for epileptic patients in clinical practice.
authors.affiliation: Gaziosmanpaşa University, School of Medicine, Physiology Department , Tokat, Turkey.
authors.forename: Oytun
authors.initials: O
authors.lastname: Erbaş
authors.forename: Volkan
authors.initials: V
authors.lastname: Solmaz
authors.forename: Dürdane
authors.initials: D
authors.lastname: Aksoy
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003292:Convulsants; D004195:Disease Models, Animal; D004569:Electroencephalography; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy*; D016896:Treatment Outcome; D014325:Tromethamine / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003292:Convulsants; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol; D010433:Pentylenetetrazole
keywords: Convulsion; Dexketoprofen; Electroencephalogram; Pentylenetetrazol; Racine's convulsion scale