title: Pros and cons of bifunctional platinum(IV) antitumor prodrugs: two are (not always) better than one.
abstract: This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale Teresa Michel 11, 15121 Alessandria, Italy. domenico.osella@unipmn.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Gabano
authors.forename: Mauro
authors.initials: M
authors.lastname: Ravera
authors.forename: Domenico
authors.initials: D
authors.lastname: Osella
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D056831:Coordination Complexes / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D017671:Platinum Compounds / Q000494:pharmacology / Q000627:therapeutic use; D011355:Prodrugs / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D017671:Platinum Compounds; D011355:Prodrugs