title: CD40 mutant expression and its clinical significance to prognosis in gastric cancer patients.
abstract: BACKGROUND
  We aimed to detect CD40 mutant expression and evaluate its clinical significance in gastric cancer.
  
  
  METHODS
  CD40 mutant expression in 78 cases of gastric cancer tissues, 10 cases of normal gastric tissues, and 10 cases of gastric adenoma tissues by immunohistochemical test. Survival analyses were also performed.
  
  
  RESULTS
  The positive CD40 mutant rate in gastric cancer was 55.1% (43/78). No positive CD40 mutant staining was observed in the normal gastric tissue or the gastric adenoma. CD40 mutants expression was significantly correlated with invasive depth, lymph metastasis, and TNM stage (P <0.05). Cases with negative CD40 mutant expression had a significantly longer median survival time than those with positive CD40 mutant expression (40 vs. 14 months, P <0.05). A lower death risk in negative CD40 mutant cases was observed comparing with positive CD40 mutant cases.
  
  
  CONCLUSIONS
  Positive CD40 mutant expression suggests a poorer prognosis of gastric cancer cases.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Zhao
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Shi
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Jie-Min
authors.initials: JM
authors.lastname: Zhao
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, People's Republic of China. jimei90@sina.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D019013:CD40 Antigens / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D050505:Mutant Proteins / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D019013:CD40 Antigens; D050505:Mutant Proteins