title: Dose and dose-rate response of lymphocyte chromosome aberrations in mice chronically irradiated within a low-dose-rate range after age adjustment.
abstract: The incidences of chromosome aberrations were analysed in splenic lymphocytes from mice that were continuously exposed to (137)Cs gamma rays within the low-dose-rate (LDR) range to evaluate the dose-response and dose-rate effects. Chromosome aberrations were detected by fluorescence in situ hybridisation method, and these were found to increase in frequency up to 8000 mGy at 20 mGy for 22 h d(-1) and to 700 mGy at 1 mGy for 22 h d(-1). Translocations increased in a linear quadratic manner with age in non-exposed mice. The dose-response relationship for the frequency of translocations at each dose rate (20 and 1 mGy for 22 h d(-1)) was obtained using age-adjusted multiple linear regression analysis. Values of the linear term, shown as the slope, decreased as the dose rate was reduced from 20 to 1 mGy for 22 h d(-1), indicating a positive dose-rate effect in the LDR range. These results will be useful for estimating the risk of LDR radiation exposure and radiation protection.
authors.affiliation: Department of Radiobiology, Institute for Environmental Sciences, 2-121 Hachazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan ksk275-tanaka@amy.hi-ho.ne.jp kmtanaka@ies.or.jp.
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Environmetrics and Biometrics, Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.affiliation: Department of Radiobiology, Institute for Environmental Sciences, 2-121 Hachazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kohda
mesh_terms: D000367:Age Factors; D000818:Animals; D002869:Chromosome Aberrations / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H