title: The salience network is responsible for switching between the default mode network and the central executive network: replication from DCM.
abstract: With the advent of new analysis methods in neuroimaging that involve independent component analysis (ICA) and dynamic causal modelling (DCM), investigations have focused on measuring both the activity and connectivity of specific brain networks. In this study we combined DCM with spatial ICA to investigate network switching in the brain. Using time courses determined by ICA in our dynamic causal models, we focused on the dynamics of switching between the default mode network (DMN), the network which is active when the brain is not engaging in a specific task, and the central executive network (CEN), which is active when the brain is engaging in a task requiring attention. Previous work using Granger causality methods has shown that regions of the brain which respond to the degree of subjective salience of a stimulus, the salience network, are responsible for switching between the DMN and the CEN (Sridharan et al., 2008). In this work we apply DCM to ICA time courses representing these networks in resting state data. In order to test the repeatability of our work we applied this to two independent datasets. This work confirms that the salience network drives the switching between default mode and central executive networks and that our novel technique is repeatable.
authors.affiliation: Bangor University, Bangor, UK. Electronic address: niagoulden@yahoo.co.uk.
authors.forename: Nia
authors.initials: N
authors.lastname: Goulden
authors.affiliation: Bangor University, Bangor, UK. Electronic address: pspaa6@bangor.ac.uk.
authors.forename: Aygul
authors.initials: A
authors.lastname: Khusnulina
authors.affiliation: Swansea University, Swansea, UK. Electronic address: n.j.davis@swansea.ac.uk.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Davis
authors.affiliation: Bangor University, Bangor, UK. Electronic address: m.bracewell@bangor.ac.uk.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Bracewell
authors.affiliation: Trinity College Dublin, Dublin, Ireland. Electronic address: arun.bokde@tcd.ie.
authors.forename: Arun L
authors.initials: AL
authors.lastname: Bokde
authors.affiliation: University College Dublin, Dublin, Ireland. Electronic address: jonathan.mcnulty@ucd.ie.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: McNulty
authors.affiliation: Bangor University, Bangor, UK. Electronic address: p.mullins@bangor.ac.uk.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Mullins
mesh_terms: D000328:Adult; D001499:Bayes Theorem; D001931:Brain Mapping / Q000379:methods; D003627:Data Interpretation, Statistical; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D012146:Rest / Q000502:physiology; D013269:Stochastic Processes