title: Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.
abstract: We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Jae Geun
authors.initials: JG
authors.lastname: Kim
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Shigetomo
authors.initials: S
authors.lastname: Suyama
authors.affiliation: 1] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Institute of Anatomy, University of Leipzig, Leipzig, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Koch
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Sungho
authors.initials: S
authors.lastname: Jin
authors.affiliation: Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa and Centro de Investigación Biomédica en Red de la Fisiopatología (CIBER) de Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Argente-Arizon
authors.affiliation: Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa and Centro de Investigación Biomédica en Red de la Fisiopatología (CIBER) de Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Argente
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Zhong-Wu
authors.initials: ZW
authors.lastname: Liu
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Marcelo R
authors.initials: MR
authors.lastname: Zimmer
authors.affiliation: 1] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Jin Kwon
authors.initials: JK
authors.lastname: Jeong
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Klara
authors.initials: K
authors.lastname: Szigeti-Buck
authors.affiliation: Institute for Diabetes and Obesity, Helmholtz Zentrum München & Technische Universität München, Germany.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Institute for Diabetes and Obesity, Helmholtz Zentrum München & Technische Universität München, Germany.
authors.forename: Cristina
authors.initials: C
authors.lastname: Garcia-Caceres
authors.affiliation: Institute for Diabetes and Obesity, Helmholtz Zentrum München & Technische Universität München, Germany.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Yi
authors.affiliation: Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Natalina
authors.initials: N
authors.lastname: Salmaso
authors.affiliation: 1] Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Flora M
authors.initials: FM
authors.lastname: Vaccarino
authors.affiliation: Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa and Centro de Investigación Biomédica en Red de la Fisiopatología (CIBER) de Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Julie
authors.initials: J
authors.lastname: Chowen
authors.affiliation: 1] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Diano
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Marcelo O
authors.initials: MO
authors.lastname: Dietrich
authors.affiliation: Institute for Diabetes and Obesity, Helmholtz Zentrum München & Technische Universität München, Germany.
authors.forename: Matthias H
authors.initials: MH
authors.lastname: Tschöp
authors.affiliation: 1] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Tamas L
authors.initials: TL
authors.lastname: Horvath
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D002452:Cell Count; D004435:Eating / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D020738:Leptin / Q000235:genetics / Q000502:physiology*; D008297:Male; D053486:Melanocortins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008854:Microscopy, Electron; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D061251:Primary Cell Culture; D011333:Pro-Opiomelanocortin / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D020738:Leptin; D053486:Melanocortins; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin