title: N-heterocyclic carbene-palladium(II)-1-methylimidazole complex-catalyzed direct C-H bond arylation of (benz)imidazoles with aryl chlorides.
abstract: (Benz)imidazoles can be efficiently functionalized by (hetero)aryl chlorides via direct C-H bond arylation in the presence of a well-defined NHC-Pd(II)-Im complex. Under the optimal conditions, various activated, unactivated, and deactivated (hetero)aryl chlorides were successfully applied as the arylating reagents to achieve the 2-(hetero)aryl (benz)imidazoles in acceptable to high yields, giving a facile and alternative methodology for the direct C-H bond arylation of (benz)imidazoles.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Chashan University Town, Wenzhou, Zhejiang Province 325035, People's Republic of China.
authors.forename: Zheng-Song
authors.initials: ZS
authors.lastname: Gu
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Chen
authors.forename: Li-Xiong
authors.initials: LX
authors.lastname: Shao
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D006571:Heterocyclic Compounds; D007093:Imidazoles; D009942:Organometallic Compounds; C030011:carbene; D010165:Palladium; D008697:Methane; C018100:1-methylimidazole