title: Fat graft, laser CO₂ and platelet-rich-plasma synergy in scars treatment.
abstract: BACKGROUND
  Many treatments have been proposed for cosmetic or functional improvement of scars. It is known that fat grafts and laser treatment can have beneficial effects on the remodeling of scar tissue, and platelet-rich plasma (PRP) can be effective during the wound-healing process. We hypothesized that laser and PRP can enhance fat graft survival and the combination would be effective in improving scars appearance.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the efficacy of these combinations in the treatment of atrophic and contractile scars.
  
  
  RESULTS
  From 2008-2013, we treated with this combination 64 patients affected by atrophic and contractile scars involving different body parts. At 6 months the patients' overall satisfaction rate was excellent for over 50% of the patients.
  
  
  CONCLUSIONS
  The association of an ablative laser CO2 with PRP and autologous fat graft seems to be a promising and effective therapeutic approach for atrophic and contractile scars.
  
  
  BACKGROUND
  PRP platelet-rich plasma, OTI orotracheal intubation, HLLT high level laser therapy, LLLT low level laser therapy.
authors.affiliation: Dermatology Department of "ProEstetica" Medical Center, Bucharest, Romania.
authors.forename: A C
authors.initials: AC
authors.lastname: Nita
authors.affiliation: Dermatology Department, Elias University Emergency Hospital, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: O A
authors.initials: OA
authors.lastname: Orzan
authors.affiliation: Plastic Surgery Department of "ProEstetica" Medical Center, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Filipescu
authors.affiliation: Plastic Surgery Department of "ProEstetica" Medical Center, Bucharest, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Jianu
mesh_terms: D000293:Adolescent; D000328:Adult; D002921:Cicatrix / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D055815:Young Adult
keywords: fat graft; platelet-rich plasma; preadipocyte; scar