title: Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C.
abstract: Purpose. To study the long term refractive and visual outcomes of photorefractive keratectomy (PRK) with intraoperative application of mitomycin C (MMC). Methods. This study included 37 eyes who received myopic PRK; after photoablation, a sponge soaked in 0.02% MMC solution was applied in all corneas for 2 minutes. Efficacy, safety, predictability, and stability of PRK MMC were evaluated. Endothelial cell density was evaluated at the last postoperative interval. Results. Mean preoperative spherical equivalent (SEQ) was -6.03 ± 1.87 D (diopters) and reduced to -0.09 ± 0.53 D at the last postoperative examination. Mean followup was 44.73 ± 18.24 months. All the eyes were in the ±1.00 D of attempted versus achieved SEQ at the one-year follow-up interval. Furthermore, 95% of the eyes did not lose lines or gained 1 to 2 lines of CDVA, while 5% lost 1 line. At the third postoperative month, 89% of the eyes either were clear or had trace haze, while 4 eyes had mild haze; by the 12-month postoperative interval, none of the eyes demonstrated haze. Mean endothelial cell density (ECD) at the last postoperative interval was 2658 ± 153 cells/mm(2). Conclusions. PRK, with intraoperative use of MMC, demonstrates stable refractive and visual outcomes up to 44 months after surgery.
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece ; Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Vasilios F
authors.initials: VF
authors.lastname: Diakonis
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece ; Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Vardhaman P
authors.initials: VP
authors.lastname: Kankariya
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece ; Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Kounis
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kontadakis
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece.
authors.forename: Eirineos
authors.initials: E
authors.lastname: Gkenos
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grentzelos
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Hajithanasis
authors.affiliation: Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Sonia H
authors.initials: SH
authors.lastname: Yoo
authors.affiliation: Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece.
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Pallikaris