title: Relapsing inappropriate antidiuretic hormone secretion in an anti-aquaporin-4 antibody positive paediatric patient.
abstract: Paediatric patients with the syndrome of an inappropriate antidiuretic hormone secretion (SIADH), as a manifestation of inflammatory demyelinating disorders of the central nervous system, have been rarely described until now, in only a few cases of neuromyelitis optica spectrum disorders (NMOSDs). We present a case of relapsing SIADH associated with NMOSD, in an anti-aquaporin-4 antibody positive 14-year-old girl, who is, to our best knowledge, the first reported paediatric patient with relapsing SIADH and NMOSD. Additionally, our case further supports the notion that paediatric encephalomyelitis associated with SIADH should suggest the diagnosis of NMOSD.
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia / Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia.
authors.forename: Ruzica
authors.initials: R
authors.lastname: Kravljanac
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia.
authors.forename: Vanja
authors.initials: V
authors.lastname: Martinović
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia / Clinic of Neurology, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Dujmović
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia / Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Djurić
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia / Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia.
authors.forename: Miloš
authors.initials: M
authors.lastname: Kuzmanović
authors.affiliation: Mayo Clinic, Rochester, MN, USA.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Weinshenker
authors.affiliation: Faculty of Medicine, University of Belgrade, Serbia / Clinic of Neurology, Clinical Centre of Serbia, Belgrade, Serbia jelena60@eunet.rs.
authors.forename: Jelena
authors.initials: J
authors.lastname: Drulović
mesh_terms: D000293:Adolescent; D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009471:Neuromyelitis Optica / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D011237:Predictive Value of Tests; D012008:Recurrence; D012698:Serologic Tests; D016896:Treatment Outcome
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents
keywords: MRI; Neuromyelitis optica; anti-aquaporin-4 antibody; paediatric patient