title: Success rate of cold coagulation for the treatment of cervical intraepithelial neoplasia: a retrospective analysis of a series of cases.
abstract: OBJECTIVE
  To establish the cure rate at 1 year of patients who have undergone cold coagulation for the treatment of cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  Retrospective review of data for all patients at Shrewsbury and Telford NHS Trust who had undergone cold coagulation as part of their treatment for CIN between 2001 and 2011. Follow-up data up to December 2012 were analyzed.
  
  
  METHODS
  Colposcopy Department, Shrewsbury and Telford NHS Trust, United Kingdom.
  
  
  METHODS
  Women undergoing cold coagulation for the treatment of CIN between 2001 and 2011, with cytologic follow-up until December 2012.
  
  
  METHODS
  Patients were identified using a local colposcopy database. Data were obtained via the local histopathology reporting systems. Statistical analyses were performed using Stata/IC 10.1 software.
  
  
  METHODS
  Posttreatment cytology and whether subsequent treatment was required, with histology results.
  
  
  RESULTS
  Data on 557 patients were collected and analyzed. Pre-cold coagulation treatment histologic findings were CIN 1 in 156 patients (28.01%), CIN 2 in 260 patients (46.68%), and CIN 3 in 141 patients (25.31%). The median length of time between cold coagulation treatment and first follow-up smear, used to calculate cure rates at around 1 year, was 406 days (interquartile range 123 days, range 169-3,116 days). The cure rate after cold coagulation was 95.7% at around 1 year.
  
  
  CONCLUSIONS
  Cold coagulation has a cure rate comparable to that of excisional treatments such as large loop excision of the transformation zone and should be considered more widely in patients undergoing primary treatment for CIN, where there is no suspicion of invasive disease on history, examination and cytologic results.
authors.affiliation: 1Department of Colposcopy, Shrewsbury and Telford NHS Trust, Shrewsbury, UK; 2National Centre for Epidemiology and Population Health, Canberra, Australia; and 3Department of Gynaecological Oncology, University Hospital of North Staffordshire, Stoke-on-Trent, UK.
authors.forename: William
authors.initials: W
authors.lastname: Parry-Smith
authors.forename: Martyn
authors.initials: M
authors.lastname: Underwood
authors.forename: Sabrina
authors.initials: S
authors.lastname: De Bellis-Ayres
authors.forename: Laura
authors.initials: L
authors.lastname: Bangs
authors.forename: Charles W E
authors.initials: CW
authors.lastname: Redman
authors.forename: Jane
authors.initials: J
authors.lastname: Panikkar
mesh_terms: D000293:Adolescent; D000328:Adult; D017679:Cryotherapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative / Q000379:methods*; D016896:Treatment Outcome; D006113:United Kingdom; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000601:surgery*