title: Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis.
abstract: Objective. Gastrointestinal disfunction and acute lung injury (ALI) were common in acute pancreatitis (AP). The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of "lung and large intestine are interior exteriorly related" in traditional Chinese medicine. Methods. Male Sprague-Dawley rats were randomly divided into the normal group, model group, and EA group. AP model was established by three injections of 20% L-arginine at 1 h intervals. EA were applied to bilateral ST-25 and ST-36 for 30 minutes twice a day after modeling for 3 days. Arterial blood, pancreas, lung, and intestinal tissues were collected for detecting the inflammatory factors and histopathology. Intestinal propulsion rate (IPR) was also measured at 72 h. Results. EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05). It lowered the serum levels of TNF- α and IL-6 and increased the level of IL-4 with no effect on IL-10. EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05). Conclusion. EA treatment could promote gastrointestinal motility through inhibiting VIP, and promoting CCK expression and regulate pro- and anti-inflammatory mediators to ameliorate ALI in AP.
authors.affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
authors.forename: Shi-Feng
authors.initials: SF
authors.lastname: Zhu
authors.affiliation: The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an, Shanxi Province 712000, China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Zhang
authors.affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
authors.forename: Xian-Lin
authors.initials: XL
authors.lastname: Zhao
authors.affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Wan
authors.affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
authors.forename: Wen-Fu
authors.initials: WF
authors.lastname: Tang