title: Clinicopathologic features and prognosis of osteosarcoma in Turkish adults.
abstract: BACKGROUND
  Osteosarcomas are the most common solid malignancies of bone. In the last two decades there have been no concrete developments in their systemic treatment. In this trial we aimed to present our osteosarcoma patient clinical and demographic outcomes.
  
  
  METHODS
  Patients treated and followed up for osteosarcoma in Ankara Numune Education and Research Hospital from 2002 to 2012 were reviewed retrospectively.
  
  
  RESULTS
  A total of 21 patients (15 male, 6 female) were diagnosed with osteosarcoma. The disease was located at extremities in 76% and in 14% was metastatic at the time of diagnosis. Median disease free survival (DFS) was 36 months in non-metastatic patients and median progression free survival (PFS) was 2 months in metastatic patients (p<0.0001). Median overall survival (OS) was 80 months and 4 months, respectively (p=0.012). There were no survival differences in terms of presentation with pathological fracture, tumor size, tumor grade, alkaline phosphatase and lactate dehydrogenase level and type of chemotherapy regimen.
  
  
  CONCLUSIONS
  Tumor site and stages are the most important prognostic factors for osteosarcoma. Extremity primary tumors have beter survival rates than non-extremity tumors. As a result of the use of effective chemotherapy the long term survival rates have improved from 10-20% to 60-70% in the last decades but we need more active agents, especially for metastatic cases.
authors.affiliation: Medical Oncolgy Department, Medical Faculty, Cumhuriyet University, Sivas, Turkey E-mail : mmetinseker@yahoo.com.tr.
authors.forename: Mehmet Metin
authors.initials: MM
authors.lastname: Seker
authors.forename: Ayse
authors.initials: A
authors.lastname: Seker
authors.forename: Sercan
authors.initials: S
authors.lastname: Aksoy
authors.forename: Nuriye
authors.initials: N
authors.lastname: Ozdemir
authors.forename: Dogan
authors.initials: D
authors.lastname: Uncu
authors.forename: Nurullah
authors.initials: N
authors.lastname: Zengin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005598:Fractures, Spontaneous / Q000473:pathology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000097:blood / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D014421:Turkey; D055815:Young Adult
chemical_list: D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase