title: Lathyrane-type diterpenoids from the seeds of Euphorbia lathyris.
abstract: Ten lathyrane-type diterpenoids named Euphorbia Factor L12-L21 (1-10) and twelve known diterpenoids (11-22) were isolated from seeds of Euphorbia lathyris. The structures of these compounds were determined by extensive spectroscopic (UV, IR, HRESIMS, 1D and 2D NMR) analyses. In addition, the configuration of Euphorbia Factor L12 (1) was further confirmed by X-ray crystallographic and circular dichroism (CD) analyses. A putative biogenetic relationship to these compounds was proposed. Cytotoxicity of the isolated compounds against C6 and MCF-7 cell lines were evaluated. Compounds 1, 5, 7, 12 and 17 exhibited considerable cytotoxic activities (IC50 12.4-36.2 μM).
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
authors.affiliation: College of Pharmacy, Xinjiang Medical University, Urumqi 830011, People's Republic of China.
authors.forename: Guoyu
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of New Drug, Institute of Frontier Medical Sciences, Jilin University, Changchun 130021, People's Republic of China. Electronic address: huang_jian1977@yahoo.com.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors.forename: Cui
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Pharmacy, Xinjiang Medical University, Urumqi 830011, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of New Drug, Institute of Frontier Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Pingya
authors.initials: P
authors.lastname: Li
authors.affiliation: School of Traditional Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors.forename: Ruichao
authors.initials: R
authors.lastname: Lin
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; College of Pharmacy, Xinjiang Medical University, Urumqi 830011, People's Republic of China. Electronic address: wjh.1972@yahoo.com.cn.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053898:Biosynthetic Pathways; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010946:Plants, Medicinal; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C530347:lathyrane
keywords: Cytotoxicity; Euphorbia Factor L(12)–L(21); Euphorbia lathyris; Euphorbiaceae; Lathyrane-type diterpenoid