title: A 2014 Update on Coagulation Management for Cardiopulmonary Bypass.
abstract: Coagulopathy after cardiac surgery with cardiopulmonary bypass is a serious complication that may result in massive bleeding requiring transfusion of significant amounts of blood products, plasma, and platelets. In addition to increased patient morbidity and mortality it is associated with longer hospital stay and increased resource utilization. The current review discusses aspects in cardiopulmonary bypass-induced coagulopathy with emphasis on point-of-care testing and individualized "goal-directed" therapy in patients who develop excessive bleeding after cardiac surgery.
authors.affiliation: University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Thiele
authors.affiliation: University of Virginia Health System, Charlottesville, VA, USA jr5ef@virginia.edu.
authors.forename: Jacob
authors.initials: J
authors.lastname: Raphael
mesh_terms: D001778:Blood Coagulation Disorders / Q000628:therapy*; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D015942:Factor VIIa / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use; D006801:Humans; D019095:Point-of-Care Systems; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D014812:Vitamin K; D005340:Fibrinogen; D015942:Factor VIIa
keywords: antifibrinolytics; cardiopulmonary bypass; coagulation; coagulopathy; point-of-care monitoring