title: Serum alpha tocopherol, vitamin B12, and folate levels in childhood acute lymphoblastic leukemia survivors with and without neuropathy.
abstract: Various micronutrients are essential for optimal functioning of the peripheral nervous system. Serum vitamin E, vitamin B12, and folic acid were estimated in childhood acute lymphoblastic leukemia survivors aged between 5 and 18 years in first continuous remission within 3 years of completion of vincristine-based chemotherapy with and without electrophysiologically defined neuropathy. A total of 80 children were studied. Neuropathy was seen in 27 (33.75%) children electrophysiologically. None of the children had vitamin E deficiency. However, the alpha tocopherol/(cholesterol + triglyceride) ratio was significantly lower in children with neuropathy (P = .05). The prevalence of folate (P = .48) and vitamin B12 (P = .21) deficiency in children with and without neuropathy was not significantly different. Thus, the prevalence of deficiencies of these micronutrients was not significantly different in childhood acute lymphoblastic leukemia survivors with or without electrophysiologically defined neuropathy.
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, All India Institute of Medical Sciences, New Delhi, India Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.
authors.forename: Puneet
authors.initials: P
authors.lastname: Jain
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, All India Institute of Medical Sciences, New Delhi, India sheffaligulati@gmail.com.
authors.forename: Sheffali
authors.initials: S
authors.lastname: Gulati
authors.affiliation: ICMR Headquarters, New Delhi, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Toteja
authors.affiliation: Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.affiliation: Department of Pediatrics, Division of Pediatric Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Rachna
authors.initials: R
authors.lastname: Seth
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005494:Folic Acid Deficiency / Q000453:epidemiology; D006801:Humans; D008297:Male; D018977:Micronutrients / Q000097:blood*; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D015995:Prevalence; D017741:Survivors; D014805:Vitamin B 12 / Q000097:blood*; D014806:Vitamin B 12 Deficiency / Q000453:epidemiology; D014810:Vitamin E / Q000097:blood; D014811:Vitamin E Deficiency / Q000453:epidemiology; D024502:alpha-Tocopherol / Q000097:blood*
chemical_list: D018977:Micronutrients; D014810:Vitamin E; D005492:Folic Acid; D024502:alpha-Tocopherol; D014805:Vitamin B 12
keywords: acute lymphoblastic leukemia; folic acid deficiency; neuropathy; vitamin B12 deficiency; vitamin E