title: Effects of doxazosin as the third agent on morning hypertension and position-related blood pressure changes in diabetic patients with chronic kidney disease.
abstract: We conducted a prospective study to assess the effects of doxazosin, as the third agent, on morning and position-related blood pressure (BP) in 77 diabetic patients with chronic kidney disease, who were allocated randomly to doxazosin and diuretics groups. Doxazosin decreased morning BP but diuretics could not decrease pre-awakening diastolic BP. Only doxazosin improved sympathovagal balance. Doxazosin and diuretics decreased standing and sitting BP but only doxazosin improved sympathovagal balance regardless of body positions. Doxazosin did not decrease absolute BP changes shortly after standing. In diabetic patients, doxazosin decreased morning BP through improving sympathovagal balance without causing significant orthostatic hypotension (ClinicalTrials.gov number, NCT00295555).
authors.affiliation: Division of Nephrology and Hypertension, Yokohama City University Center Hospital , Kanagawa , Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Yasuda
authors.forename: Sanae
authors.initials: S
authors.lastname: Saka
authors.forename: Daisaku
authors.initials: D
authors.lastname: Ando
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Hirawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D003920:Diabetes Mellitus; D017292:Doxazosin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents; D017292:Doxazosin
keywords: ambulatory blood pressure monitoring; diabetic nephropathy; orthostatic hypotension; power spectral analysis; sympathetic nervous activity; α1-adrenergic antagonists