title: Hematologic toxicity in patients undergoing radical anti- cancer therapy: a cross-sectional analysis of patients in an oncology ward in India.
abstract: Burden of cancer is progressively increasing in developing countries like India which has also led to a steep rise in toxicity due to anti-cancer therapy. A cross-sectional analysis was here conducted for patients with different malignancies (except leukaemia) who while undergoing radical anti-cancer therapy were admitted to our oncology ward from January-July 2013. In a total of 280 patients, the total number of toxicity events was 473. Nine patients expired over this time period. Among the events, grade 2 anaemia the most common (n=189) while the most common grades of neutropenia and thrombocytopenia were grade 4 (n=114) and grade 2 (n=48), respectively. Among the tracable microbial etiologies, gram negative bacteria were the most commonly found pathogens. Treatment interruptions took place in 240 patients (median duration=8.8 days). Prolonged hospital admission, intensive care and artificial ventilation support was needed to be given in 48, 7 and 13 patients respectively. Advanced NSCLC, KPS <70, pancytopenia and artificial ventilation requirement were found to have a significant impact on death. Such studies show the prevailing practice from institutes of our country and may guide us formulating a guideline for managing such toxicities for this part of the world.
authors.affiliation: Department of Radiation Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India E-mail : soumyajitroy8@gmail.com.
authors.forename: Soumyajit
authors.initials: S
authors.lastname: Roy
authors.forename: Supriya
authors.initials: S
authors.lastname: Mallick
authors.forename: Md Waseem
authors.initials: MW
authors.lastname: Raza
authors.forename: Kunhi Parambath
authors.initials: KP
authors.lastname: Haresh
authors.forename: Subhash
authors.initials: S
authors.lastname: Gupta
authors.forename: Daya Nand
authors.initials: DN
authors.lastname: Sharma
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Julka
authors.forename: Goura Kisore
authors.initials: GK
authors.lastname: Rath
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000209:etiology; D006801:Humans; D007194:India; D007362:Intensive Care Units / Q000706:statistics & numerical data; D017567:Karnofsky Performance Status; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000209:etiology; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D009503:Neutropenia / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D013921:Thrombocytopenia / Q000209:etiology*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents