title: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
abstract: BACKGROUND
  We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.
  
  
  METHODS
  We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.
  
  
  RESULTS
  We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P(trend) = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P(trend) = 0.005) but not cases (P(trend) = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P(het) = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR(het) = 0.84, 95% CI 0.75, 0.94; OR(hom) = 0.81, 95% CI 0.51, 1.30; P(trend) = 0.002) but not for those who had their menarche age ≤11 years (OR(het) = 1.06, 95% CI 0.95, 1.19, OR(hom) = 1.07, 95% CI 0.67, 1.72; P(trend) = 0.29).
  
  
  CONCLUSIONS
  To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
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authors.initials: H
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authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. j.chang-claude@dkfz-heidelberg.de.
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authors.initials: J
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authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.rudolph@dkfz.de.
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authors.affiliation: Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Via Giuseppe Ripamonti 435, 20141, Milan, Italy. bernardo.bonanni@ieo.it.
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authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. valeria.pensotti@ifom.eu.|Cogentech Cancer Genetic Test Laboratory, IFOM-IEO Campus, Via Adamello16, 20139, Milan, Italy. valeria.pensotti@ifom.eu.
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authors.affiliation: Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. olsonj@mayo.edu.
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authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. wang.xianshu@mayo.edu.
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authors.affiliation: Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Zach.Fredericksen@northerntool.com.
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authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. Graham.Giles@cancervic.org.au.|Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia. Graham.Giles@cancervic.org.au.
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authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. Gianluca.severi@cancervic.org.au.|Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia. Gianluca.severi@cancervic.org.au.
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authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. Laura.baglietto@cancervic.org.au.|Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia. Laura.baglietto@cancervic.org.au.
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authors.initials: L
authors.lastname: Baglietto
authors.affiliation: Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Oude Markt 13 - bus 5005, 3000, Leuven, Belgium. Christopher.Haiman@med.usc.edu.
authors.forename: Chris
authors.initials: C
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authors.affiliation: Department of Medicine, McGill University and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada. jacques.simard@crchul.ulaval.ca.
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authors.initials: J
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authors.affiliation: Department of Medicine, McGill University and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada. mark.goldberg@mcgill.ca.
authors.forename: Mark S
authors.initials: MS
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authors.affiliation: Department of Social and Preventive Medicine and Department of Environmental and Occupational Health at Work, University of Montréal, Marguerite d'Youville Pavilion, 2375 Côte Ste-Catherine, Suite 4095, Montréal, Québec, H3T 1A8, Canada. France.Labreche@irsst.qc.ca.
authors.forename: France
authors.initials: F
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authors.affiliation: Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2325 Rue de l'Université, Québec City, Québec, G1V 0A6, Canada. martine.dumont@crchul.ulaval.ca.
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authors.initials: M
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authors.affiliation: Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2325 Rue de l'Université, Québec City, Québec, G1V 0A6, Canada. penny.soucy@crchul.ulaval.ca.
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authors.affiliation: Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. soohwang.teo@carif.com.my.|Cancer Research Initiatives Foundation, Sime Darby Medical Centre Subang Jaya, 1, Jalan SS 12 / 1A, 47500, Subang Jaya, Selangor Darul Ehsan, Malaysia. soohwang.teo@carif.com.my.
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authors.initials: S
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authors.affiliation: Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. yipch@um.edu.my.
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authors.lastname: Yip
authors.affiliation: Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. szeyee.phuah@carif.com.my.|Cancer Research Initiatives Foundation, Sime Darby Medical Centre Subang Jaya, 1, Jalan SS 12 / 1A, 47500, Subang Jaya, Selangor Darul Ehsan, Malaysia. szeyee.phuah@carif.com.my.
authors.forename: Sze Yee
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authors.lastname: Phuah
authors.affiliation: Singapore Eye Research Institute, National University of Singapore, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore. belinda.cornes@gmail.com.
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authors.affiliation: Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0310, Oslo, Norway. Vessela.N.Kristensen@rr-research.no.|Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372, Oslo, Norway. Vessela.N.Kristensen@rr-research.no.
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authors.affiliation: Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372, Oslo, Norway. Grethe.I.Grenaker.Alnas@rr-research.no.
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authors.lastname: Grenaker Alnæs
authors.affiliation: Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0310, Oslo, Norway. alb@radium.uio.no.|Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372, Oslo, Norway. alb@radium.uio.no.
authors.forename: Anne-Lise
authors.initials: AL
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authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # T1217, Nashville, TN, 37232, USA. wei.zheng@Vanderbilt.Edu.
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authors.initials: R
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authors.affiliation: Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, 90220, Oulu, Finland. katri.pylkas@oulu.fi.
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authors.affiliation: Department of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, 90220, Oulu, Finland. arja.jukkola-vuorinen@ppshp.fi.
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authors.initials: A
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authors.lastname: Andrulis
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 982 - 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. knight@lunenfeld.ca.|Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 6th floor, 155 College St, Toronto, Ontario, M5T 3M7, Canada. knight@lunenfeld.ca.
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authors.lastname: Knight
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 982 - 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. gglendon@uhnresearch.ca.|Ontario Cancer Genetics Network, 620 University Avenue, Toronto, Ontario, M5G 2L7, Canada. gglendon@uhnresearch.ca.
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authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Cir, Toronto, Ontario, M5S 1A8, Canada. AnnaMarie.Mulligan@uhn.ca.|University Health Network, R. Fraser Elliott Building, 1st Floor, 190 Elizabeth St, Toronto, Ontario, M5G 2C4, Canada. AnnaMarie.Mulligan@uhn.ca.
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authors.initials: AM
authors.lastname: Mulligan
authors.affiliation: Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Einthovenweg 20, 2333, ZC, Leiden, The Netherlands. p.devilee@lumc.nl.
authors.forename: Peter
authors.initials: P
authors.lastname: Devillee
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. figueroaj@mail.nih.gov.
authors.forename: Jonine
authors.initials: J
authors.lastname: Figueroa
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. chanocks@mail.nih.gov.
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authors.initials: SJ
authors.lastname: Chanock
authors.affiliation: Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Roentena 5, 02-781, Warsaw, Poland. lissowsj@coi.waw.pl.
authors.forename: Jolanta
authors.initials: J
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. shermanm@mail.nih.gov.
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authors.initials: ME
authors.lastname: Sherman
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solnavägen 1, Stockholm, 17177, Sweden. Per.Hall@ki.se.
authors.forename: Per
authors.initials: P
authors.lastname: Hall
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authors.initials: N
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authors.affiliation: Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands. a.hollestelle@erasmusmc.nl.
authors.forename: Antoinette
authors.initials: A
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authors.affiliation: Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands. r.oldenburg@erasmusmc.nl.
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authors.affiliation: Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands. m.tilanus-linthorst@erasmusmc.nl.
authors.forename: Madeleine
authors.initials: M
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authors.affiliation: Human Genetics Division, Genome Institute of Singapore, 60 Biopolis St, Singapore, 138672, Singapore. liuj3@gis.a-star.edu.sg.
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authors.affiliation: Institute for Cancer Studies, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. a.cox@sheffield.ac.uk.
authors.forename: Angie
authors.initials: A
authors.lastname: Cox
authors.affiliation: Institute for Cancer Studies, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. i.w.brock@shef.ac.uk.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Brock
authors.affiliation: Academic Unit of Surgical Oncology, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. m.w.reed@sheffield.ac.uk.
authors.forename: Malcolm W R
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authors.lastname: Reed
authors.affiliation: Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. s.s.cross@sheffield.ac.uk.
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authors.initials: SS
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authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # T1217, Nashville, TN, 37232, USA. william.j.blot@Vanderbilt.Edu.|International Epidemiology Institute, 1455 Research Blvd, Rockville, MD, 20850, USA. william.j.blot@Vanderbilt.Edu.
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authors.lastname: Blot
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. Signorello@hsph.harvard.edu.|Channing Division of Network Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. Signorello@hsph.harvard.edu.|Dana-Farber/Harvard Cancer Center, 450 Brookline Ave, Boston, MA, 02215, USA. Signorello@hsph.harvard.edu.
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authors.lastname: Signorello
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. paul.pharoah@srl.cam.ac.uk.
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authors.initials: M
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authors.affiliation: Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E, Kent Ridge Road, Singapore, 119228, Singapore. mikael_hartman@nuhs.edu.sg.|National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore. mikael_hartman@nuhs.edu.sg.|Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore, 117597, Singapore. mikael_hartman@nuhs.edu.sg.
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authors.initials: M
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authors.affiliation: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. ephmh@nus.edu.sg.|Channing Division of Network Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. ephmh@nus.edu.sg.
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authors.affiliation: National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore. ephlwy@nus.edu.sg.|Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore, 117597, Singapore. ephlwy@nus.edu.sg.
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authors.initials: A
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authors.affiliation: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. u.hamann@dkfz-heidelberg.de.
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authors.initials: U
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authors.affiliation: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. A.Foersti@dkfz-heidelberg.de.|Center for Primary Health Care Research, University of Lund, Paradisgatan 5, SE-221 00, Lund, Malmö, Sweden. A.Foersti@dkfz-heidelberg.de.
authors.forename: Asta
authors.initials: A
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authors.affiliation: Institute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133, Karlsruhe, Germany. Thomas.Ruediger@klinikum-karlsruhe.de.
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authors.initials: T
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authors.affiliation: Frauenklinik der Stadtklinik Baden-Baden, Balger Strasse 50, 76532, Baden-Württemberg, Germany. hu.ulmer@klinikum-mittelbaden.de.
authors.forename: Hans Ulrich
authors.initials: HU
authors.lastname: Ulmer
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. aniaj@sci.pam.szczecin.pl.
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authors.initials: A
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authors.initials: J
authors.lastname: Lubinski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. ka_jaworska@wp.pl.|Postgraduate School of Molecular Medicine, Warsaw Medical University, Żwirki i Wigury 61, 02-091, Warsaw, Poland. ka_jaworska@wp.pl.
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authors.initials: K
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authors.initials: K
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authors.affiliation: National Cancer Institute, 268/1 Rama VI Road, Rajathevi, Bangkok, 10400, Thailand. sulee@health.moph.go.th.
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authors.affiliation: International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. gaborieau@iarc.fr.
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authors.initials: V
authors.lastname: Gaborieau
authors.affiliation: International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. brennan@iarc.fr.
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authors.initials: P
authors.lastname: Brennan
authors.affiliation: International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. mckay@iarc.fr.
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authors.affiliation: Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. slager.susan@mayo.edu.
authors.forename: Susan
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authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 410 W. 10th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Toland
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. vachon.celine@mayo.edu.
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authors.affiliation: Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis 153 10, Athens, Greece. yannouka@rrp.demokritos.gr.
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authors.affiliation: College of Public Health, China Medical University, No.91, Hsueh-Shih Road, Taichung, 40402, Taiwan. bmcys@ibms.sinica.edu.tw.|Institute of Biomedical Sciences, Academia Sinica, 2 Academia Road, Nankang, Taipei 115, Taiwan. bmcys@ibms.sinica.edu.tw.
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authors.initials: CY
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authors.initials: JC
authors.lastname: Yu
authors.affiliation: Department of Surgery, National Taiwan University Hospital, No.1, Changde Street, Taipei City, 10048, Zhongzheng District, Taiwan. huangcs@ntu.edu.tw.
authors.forename: Chiun-Sheng
authors.initials: CS
authors.lastname: Huang
authors.affiliation: Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan. mifeho@kmu.edu.tw.|Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan. mifeho@kmu.edu.tw.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.affiliation: Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029, Madrid, Spain. agonzalez@cnio.es.
authors.forename: Anna
authors.initials: A
authors.lastname: González-Neira
authors.affiliation: McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec, H3A 0G1, Canada. dtessier@genomequebec.com.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Tessier
authors.affiliation: McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec, H3A 0G1, Canada. daniel.vincent@mail.mcgill.ca.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vincent
authors.affiliation: McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec, H3A 0G1, Canada. francois.bacot@mail.mcgill.ca.
authors.forename: Francois
authors.initials: F
authors.lastname: Bacot
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. cl533@medschl.cam.ac.uk.
authors.forename: Craig
authors.initials: C
authors.lastname: Luccarini
authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. jgd29@cam.ac.uk.
authors.forename: Joe
authors.initials: J
authors.lastname: Dennis
authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. km533@medschl.cam.ac.uk.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Michailidou
authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. mkh39@medschl.cam.ac.uk.
authors.forename: Manjeet K
authors.initials: MK
authors.lastname: Bolla
authors.affiliation: Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. jccw2@medschl.cam.ac.uk.
authors.forename: Jean
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.|Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Montse.GarciaClosas@icr.ac.uk.|Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Montse.GarciaClosas@icr.ac.uk.|Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. Montse.GarciaClosas@icr.ac.uk.
authors.forename: Montserrat
authors.initials: M
authors.lastname: García-Closas
authors.affiliation: The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK. Mitch.Dowsett@icr.ac.uk.
authors.forename: Mitch
authors.initials: M
authors.lastname: Dowsett
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Alan.Ashworth@icr.ac.uk.|Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Alan.Ashworth@icr.ac.uk.
authors.forename: Alan
authors.initials: A
authors.lastname: Ashworth
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Anthony.Swerdlow@icr.ac.uk.|Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Anthony.Swerdlow@icr.ac.uk.|Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. Anthony.Swerdlow@icr.ac.uk.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Swerdlow
authors.affiliation: Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Julian.Peto@lshtm.ac.uk.
authors.forename: Julian
authors.initials: J
authors.lastname: Peto
authors.affiliation: Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Isabel.Silva@lshtm.ac.uk.
authors.forename: Isabel
authors.initials: I
authors.lastname: dos Santos Silva
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Olivia.Fletcher@icr.ac.uk.|Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Olivia.Fletcher@icr.ac.uk.
authors.forename: Olivia
authors.initials: O
authors.lastname: Fletcher
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008572:Menarche / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017697:Premenopause / Q000235:genetics; D017584:Reproductive History; D012307:Risk Factors; D044465:White People
chemical_list: D051544:Cytochrome P-450 CYP3A