title: Cellular and molecular mechanisms of cartilage damage and repair.
abstract: Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.
authors.affiliation: Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, UK.
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Sherwood
authors.affiliation: Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Bertrand
authors.affiliation: Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, UK.
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Eldridge
authors.affiliation: Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, UK. Electronic address: f.dellaccio@qmul.ac.uk.
authors.forename: Francesco
authors.initials: F
authors.lastname: Dell'Accio
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000473:pathology / Q000503:physiopathology; D002356:Cartilage / Q000473:pathology* / Q000503:physiopathology*; D019902:Chondrocytes / Q000473:pathology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D010003:Osteoarthritis / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*