title: [Endothelial dysfunction gene polymorphisms and the rate of liver fibrosis in chronic hepatitis C].
abstract: OBJECTIVE
  To assess the association of the CYBA, NOS3, and MTHFR gene polymorphisms and a rate of fibrosis progression in chronic hepatitis C (CHC).
  
  
  METHODS
  One hundred and nine CHC patients with the verified stage of liver fibrosis and cirrhosis at its onset were examined. The disease duration was determined in all the patients and additional risk factors of liver lesion were absent. A group of rapidly progressive fibrosis comprised 55 patients with a calculated fibrosis progression rate of 0.130 fibrosis units/year or higher and 54 patients with a progression rate of less than 0.130 fibrosis units/year were assigned to a slow fibrosis group. A compression group consisted of 299 healthy blood donors. The polymorphism of the genes under study was determined by polymerase chain reaction-restriction fragment length polymorphism analysis.
  
  
  RESULTS
  The mutant TT genotype of the CYBA gene was significantly more common in the CHC patients with rapidly progressive fibrosis than in those with slowly progressive fibrosis (odds ratio for TT 9.09 at 95% confidence interval, 1.09 to 74.83; p = 0.0161). No significant differences were found in the distribution of the alleles and genotypes of the NOS3 and MTHFR genes between the groups of patients with slowly and rapidly progressive fibrosis.
  
  
  CONCLUSIONS
  The findings make it possible to regard the TT genotype of the CYBA gene from the C242T locus as profibrogenic and as one of the markers of the poor course of CHC.
authors.forename: O V
authors.initials: OV
authors.lastname: Taratina
authors.forename: T N
authors.initials: TN
authors.lastname: Krasnova
authors.forename: L M
authors.initials: LM
authors.lastname: Samokhodskaia
authors.forename: T N
authors.initials: TN
authors.lastname: Lopatkina
authors.forename: V A
authors.initials: VA
authors.lastname: Tkachuk
authors.forename: N A
authors.initials: NA
authors.lastname: Mukhina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D018384:Oxidative Stress / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D055815:Young Adult
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D019255:NADPH Oxidases; C086986:CYBA protein, human