title: Oscillations, networks, and their development: MEG connectivity changes with age.
abstract: Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha and beta frequency ranges and to express strong congruence with RSN topologies found using fMRI. Despite such advances, little is known about how oscillatory connectivity in RSNs develops throughout childhood and adolescence. This study used a novel fMRI-guided MEG approach to investigate the maturation of resting-state amplitude correlations in physiologically relevant frequency ranges within and among six RSNs in 59 participants, aged 6-34 years. We report age-related increases in inter-regional amplitude correlations that were largest in alpha and beta frequency bands. In contrast to fMRI reports, these changes were observed both within and between the various RSNs analyzed. Our results provide the first evidence of developmental changes in spontaneous neurophysiological connectivity in source-resolved RSNs, which indicate increasing integration within and among intrinsic functional brain networks throughout childhood, adolescence, and early adulthood.
authors.affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada; Institute of Anatomy and Cell Biology, University of Heidelberg, Germany.
authors.forename: Carmen B
authors.initials: CB
authors.lastname: Schäfer
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Morgan
authors.forename: Annette X
authors.initials: AX
authors.lastname: Ye
authors.forename: Margot J
authors.initials: MJ
authors.lastname: Taylor
authors.forename: Sam M
authors.initials: SM
authors.lastname: Doesburg
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging; D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply / Q000254:growth & development*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D009415:Nerve Net / Q000098:blood supply / Q000254:growth & development*; D010100:Oxygen / Q000097:blood; D012146:Rest; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: alpha-band; beta-band; development; functional connectivity; functional magnetic resonance imaging; magnetoencephalography; neural network; neural oscillations; neural synchrony; resting-state networks