title: Orthostatic and supine blood pressures are associated with white matter hyperintensities in Parkinson disease.
abstract: OBJECTIVE
  Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson's disease (PD).
  
  
  METHODS
  We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated using the semiquantitative visual rating system proposed by Scheltens et al.
  
  
  RESULTS
  The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score.
  
  
  CONCLUSIONS
  This finding indicates that hemodynamic changes associated with orthostatic hypotension may be associated with white matter changes in patients with PD.
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Yoon-Sang
authors.initials: YS
authors.lastname: Oh
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Joong-Seok
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Lee
keywords: Orthostatic hypotension; Parkinson disease; Supine blood pressure; White matter hyperintensity