title: Reasons for nonadherence to tamoxifen and aromatase inhibitors for the treatment of breast cancer: a literature review.
abstract: Despite improved breast cancer survival rates with the use of tamoxifen and aromatase inhibitors, patients remain at risk for cancer recurrence and mortality because of nonadherence to medication. The objective of this review was to identify factors associated with nonadherence among patients with breast cancer. Electronic databases were searched for studies, and potentially relevant studies were retrieved and assessed for eligibility. Potential factors associated with nonadherence were identified, and they included patient-related factors (e.g., patient beliefs and knowledge, fear of adverse effects, forgetfulness, smoking, age, race), therapy-related factors (e.g., duration, side effects, additional prescribed medications, treatment interfering with lifestyle), healthcare system factors (e.g., patient/provider relationships), socioeconomic factors (e.g., medication costs, burden, scheduling problems, religion, marital status), and disease-related factors (e.g., comorbidities, stage of breast cancer). Those findings highlight the need for development of interventions to promote long-term adherence in patients with breast cancer.
authors.affiliation: Department of BioHealth Informatics, School of Informatics, Indiana University-Purdue University in Indianapolis.
authors.forename: Suhila
authors.initials: S
authors.lastname: Sawesi
authors.affiliation: Center for Enhancing Quality of Life in Chronic Illness, School of Nursing, Indiana University-Purdue University in Indianapolis.
authors.forename: Janet S
authors.initials: JS
authors.lastname: Carpenter
authors.affiliation: Department of BioHealth Informatics in the School of Informatics, Indiana University-Purdue University in Indianapolis.
authors.forename: Josette
authors.initials: J
authors.lastname: Jones
mesh_terms: D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D006801:Humans; D010349:Patient Compliance / Q000523:psychology*; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D013629:Tamoxifen
keywords: aromatase inhibitors; breast cancer; chemotherapy; informatics and electronic health records; patient/public education; tamoxifen