title: [Cytokines and myeloma bone disease].
abstract: Multiple myeloma (MM) develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. MM cells produce a variety of cytokines to stimulate RANK ligand-mediated osteoclastogenesis and suppress osteoblastic differentiation from bone marrow stromal cells, leading to extensive bone destruction with rapid loss of bone. MM cells alter through bone destruction the microenvironment in bone where they colonize, which in turn favors tumor growth and survival, thereby forming a progressive vicious cycle between tumor expansion and bone destruction in MM.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002454:Cell Differentiation; D060833:Cellular Microenvironment; D054405:Chemokine CCL3 / Q000502:physiology; D054407:Chemokine CCL4 / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D020381:Interleukin-17 / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D009101:Multiple Myeloma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology; D053245:RANK Ligand / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D020381:Interleukin-17; D008565:Membrane Proteins; D053245:RANK Ligand; D048051:p38 Mitogen-Activated Protein Kinases; C515429:CCL3 protein, human; C066507:CCL4 protein, human; C501126:DKK1 protein, human; C109618:SFRP2 protein, human; D000094742:Secreted Frizzled-Related Proteins