title: Infections in patients with cystic fibrosis: diagnostic microbiology update.
abstract: Survival has improved in patients with cystic fibrosis (CF), in part because of aggressive antimicrobial management. Two multidrug-resistant environmental bacteria, the Burkholderia cepacia group and nontuberculous mycobacteria, have emerged. Improving genomic and proteomic technologies are allowing better identification of bacteria and fungi found in the CF lung and detection of viral agents that may be associated with pulmonary exacerbations. Anaerobic bacteria and Streptococcus angionsus group organisms may play a role in chronic CF lung infections. The diversity of organisms declines perhaps as a result of aggressive antimicrobial therapy, and an apex predator, Pseudomonas aeruginosa, may emerge in many patients with CF.
authors.affiliation: Pathology-Laboratory Medicine and Microbiology-Immunology, Clinical Microbiology-Immunology Laboratories, UNC Health Care, UNC Hospitals, UNC School Medicine, Room 1035, CB 7600, Chapel Hill, NC 27516, USA. Electronic address: gilliganncphd@gmail.com.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Gilligan
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D001424:Bacterial Infections / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D003550:Cystic Fibrosis / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D005541:Forced Expiratory Volume; D006801:Humans; D064307:Microbiota; D012141:Respiratory Tract Infections / Q000150:complications* / Q000382:microbiology
keywords: Cystic fibrosis; Diagnostic microbiology; Infection; Update