title: Impact of obstructive sleep apnea on the 24-h metabolic hormone profile.
abstract: OBJECTIVE
  Obstructive sleep apnea (OSA) has been associated with metabolic disorders. Sleep-disordered breathing could generate an altered rhythm in the expression of metabolic hormones, which could predispose to metabolic disorders. The aim of this study was to evaluate the effect of sleep apnea on diurnal variations in metabolic hormones.
  
  
  METHODS
  Thirty-seven male, newly diagnosed, patients with OSA with an apnea-hypopnea index (AHI) > or = 20/h and 11 male controls (AHI <10/h) matched for body mass index (±3 kg/m2) were included. Six different samples were obtained from each subject during a period of 24h. Levels of the metabolic hormones ghrelin, leptin, resistin, and adiponectin were measured in plasma by immunoassay.
  
  
  RESULTS
  Patients with OSA (AHI (mean±SD) 46±26/h) were older than the controls (42±9 vs. 33±9 years, P=0.01). Differences in metabolic hormones between groups did not reach statistical significance at any point in the evaluation. No significant differences were observed in the area under the curve for any of the hormones analysed. Likewise, we did not detect diurnal variations in metabolic hormones.
  
  
  CONCLUSIONS
  The results of this study indicate that the day-night variations in the levels of several metabolic hormones are not influenced by the presence of sleep apnea.
authors.affiliation: Respiratory Department, Hospital Arnau de Vilanova, IRB Lleida, University of Lleida, Catalonia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Electronic address: sanchezdelatorre@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-de-la-Torre
authors.affiliation: Clinic Analysis and Respiratory Services, Hospital Universitari Son Espases, Institut de Investigació Sanitaria de Palma (IdisPa), Palma de Mallorca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Barceló
authors.affiliation: Clinic Analysis and Respiratory Services, Hospital Universitari Son Espases, Institut de Investigació Sanitaria de Palma (IdisPa), Palma de Mallorca, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Piérola
authors.affiliation: Clinic Analysis and Respiratory Services, Hospital Universitari Son Espases, Institut de Investigació Sanitaria de Palma (IdisPa), Palma de Mallorca, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: de la Peña
authors.affiliation: Department of Statistics, IRB Lleida, Lleida, Catalonia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Valls
authors.affiliation: Respiratory Department, Hospital Arnau de Vilanova, IRB Lleida, University of Lleida, Catalonia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Barbé
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005768:Gastrointestinal Hormones / Q000097:blood; D054439:Ghrelin / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology* / Q000503:physiopathology; D052243:Resistin / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D052242:Adiponectin; D005768:Gastrointestinal Hormones; D054439:Ghrelin; D020738:Leptin; D052243:Resistin
keywords: Circadian rhythms; Day–night variations; Metabolic hormones; Metabolism; OSA; Sleep apnea