title: Changes in activated partial thromboplastin time and international normalised ratio after on-pump and off-pump surgical revascularization of the heart.
abstract: Surgical revascularization of the heart (CABG - coronary artery bypass grafting) is one way of treating coronary heart disease. Bleeding is one of the serious and frequent complications of heart surgery and can result in increased mortality and morbidity. Hemostasis disorder may be secondary consequences of surgical bleeding, preoperative anticoagulant therapy, and the use of cardiopulmonary bypass. Tests used for routine evaluation of the coagulation system are activated partial thromboplastin time (APTT) and international normalized ratio (INR). The study encountered 60 patients who were hospitalized at the Clinic for Cardiovascular Diseases, University Clinical Center Tuzla. Patients underwent elective coronary artery bypass heart surgery either with cardiopulmonary bypass (on-pump CABG) or without it (off-pump CABG). The aim of this study was to compare the changes in coagulation tests (APTT, INR) in patients who were operated on-pump and patients operated off-pump. Our study showed that the values of APTT and INR tend to increase immediately after surgery. Twenty-four hours after surgery these values are declining and they are approaching the preoperative values in all observed patients (p <0.05). Comparing APTT between the groups we found that postoperative APTT levels are significantly higher in the group of patients who underwent surgery with cardiopulmonary bypass (p <0.05). Changes in coagulation tests after surgical revascularization of the heart are more pronounced in patients who were operated with on-pump technique compared to patients operated off-pump technique.
authors.affiliation: Clinic for Cardiovascular Diseases, University Clinical Center Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Lejla
authors.initials: L
authors.lastname: Selimović Čeke
authors.affiliation: Clinic of Anaesthesiology and Reanimatology, University Clinical Centre Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Semir
authors.initials: S
authors.lastname: Imamović
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Tuzla, Univerzitetska 1, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Farid
authors.initials: F
authors.lastname: Ljuca
authors.affiliation: Clinic for Cardiovascular Diseases, University Clinical Center Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Jerkić
authors.affiliation: Fresenius Medical Care GmbH, Vrazova 22, 71000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Goran
authors.initials: G
authors.lastname: Imamović
authors.affiliation: Clinic of Anaesthesiology and Reanimatology, University Clinical Centre Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Munevera
authors.initials: M
authors.lastname: Hadžimešić
authors.affiliation: Clinic of Anaesthesiology and Reanimatology, University Clinical Centre Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Aida
authors.initials: A
authors.lastname: Pojskić
authors.affiliation: Clinic for Cardiovascular Diseases, University Clinical Center Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Kovčić
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D015331:Cohort Studies; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011184:Postoperative Period