title: [A case of effective neoadjuvant chemotherapy (MVEC) against right ureteral cancer involving bladder (cT4N1M0)].
abstract: Poorly differentiated ureteral cancer has a poor prognosis, and tumor recurrence is frequent even after nephroureterectomy. We performed neoadjuvant chemotherapy to prevent postoperative recurrence. A 74-year-old man was diagnosed with ureteral cancer (3 cm) by magnetic resonance imaging (MRI). The clinical stage was T4N1M0. Histological examination by transurethral biopsy revealed an urothelial carcinoma, G3, pT1. After a month, the tumor size increased from 3.0 cm to 4.0 cm. With two cycles of neoadjuvant chemotherapy consisting of methotrexate, vinblastine, epirubicin and cisplatin (MVEC) partial remission (regression rate : 87%) was achieved, Following MVEC, right retroperitoneoscopy-assisted nephroureterectomy, total cystectomy, and ileal conduit were performed. Pathological stage was pT0. After two years, postoperative recurrence has not appeared.
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okada
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsushita
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kawamura
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ujike
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Mikio
authors.initials: M
authors.lastname: Nin
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Masao
authors.initials: M
authors.lastname: Tsujihata
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D016896:Treatment Outcome; D014516:Ureteral Neoplasms / Q000473:pathology / Q000628:therapy*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D015251:Epirubicin; D014747:Vinblastine; D002945:Cisplatin; D008727:Methotrexate