title: From ventral-medial to dorsal-lateral striatum: neural correlates of reward-guided decision-making.
abstract: The striatum is critical for reward-guided and habitual behavior. Anatomical and interference studies suggest a functional heterogeneity within striatum. Medial regions, such as nucleus accumbens core and dorsal medial striatum play roles in goal-directed behavior, while dorsal lateral striatum is critical for control of habitual action. Subdivisions of striatum are topographically connected with different cortical and subcortical structures forming channels that carry information related to limbic, associative, and sensorimotor functions. Here, we describe data showing that as one progresses from ventral-medial to dorsal-lateral striatum, there is a shift from more prominent value encoding to activity more closely related to associative and motor aspects of decision-making. In addition, we will describe data suggesting that striatal circuits work in parallel to control behavior and that regions within striatum can compensate for each other when functions are disrupted.
authors.affiliation: Department of Psychology, University of Maryland, College Park, MD 20742, United States; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, United States.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Burton
authors.affiliation: Department of Physiology, Kansai Medical University, Shin-machi, Hirakata City, Osaka 570-1010, Japan; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.
authors.forename: Kae
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Psychology, University of Maryland, College Park, MD 20742, United States; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, United States. Electronic address: mroesch@umd.edu.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Roesch
mesh_terms: D000818:Animals; D003657:Decision Making / Q000502:physiology*; D006801:Humans; D008253:Macaca mulatta; D017072:Neostriatum / Q000033:anatomy & histology / Q000502:physiology*; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000502:physiology*; D011597:Psychomotor Performance; D051381:Rats; D012201:Reward; D066328:Ventral Striatum / Q000033:anatomy & histology / Q000502:physiology
keywords: Goal; Habit; Monkey; Nucleus accumbens; Rat; Single unit; Striatum; Value