title: Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study.
abstract: Resveratrol has been found to have potent antioxidant, anti-inflammatory, and anticarcinogenic effects. The safety and efficacy of resveratrol supplementation in older adults are currently unknown. We conducted a double-blind, randomized, placebo-controlled trial to examine the safety and metabolic outcomes in 32 overweight, older adults (mean age, 73±7years). Participants were randomized into one of three treatment groups: (1) placebo, (2) moderate dose resveratrol (300mg/day), and (3) high dose resveratrol (1000mg/day). Both resveratrol and placebo were orally ingested in capsule form twice daily for 90days. Blood chemistry values remained within the normal range, and there were no significant differences in the number of participants reporting adverse events across conditions. Compared to placebo, glucose levels were significantly lower at post-treatment among participants randomized to both resveratrol conditions, with and without adjustment for the corresponding baseline values (ps<0.05). Glucose values of participants in the treatment groups, however, were not significantly different from baseline levels. These findings suggest that short-term resveratrol supplementation at doses of 300mg/day and 1000mg/day does not adversely affect blood chemistries and is well tolerated in overweight, older individuals. These findings support the study of resveratrol for improving cardio-metabolic health in older adults in larger clinical trials.
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA. Electronic address: santon@ufl.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Anton
authors.affiliation: Progressive Medical Research, Port Orange, FL, USA.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Embry
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Marsiske
authors.affiliation: Department of Biostatistics, University of Florida, Gainesville, FL, USA.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Statistics, University of Florida, Gainesville, FL, USA.
authors.forename: Hani
authors.initials: H
authors.lastname: Doss
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
authors.forename: Christiaan
authors.initials: C
authors.lastname: Leeuwenburgh
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: tmanini@ufl.edu.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
mesh_terms: D000368:Aged; D000886:Anthropometry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001786:Blood Glucose / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D019587:Dietary Supplements / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000097:blood; D010865:Pilot Projects; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000009:adverse effects*; D055105:Waist Circumference / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D013267:Stilbenes; D000077185:Resveratrol
keywords: Blood pressure; Glucose; Metabolism; Resveratrol; Safety