title: Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay.
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Electronic address: cuk21@cam.ac.uk.
authors.forename: Claudio U
authors.initials: CU
authors.lastname: Köser
authors.affiliation: Genomics and Health Unit, FISABIO, Valencia, Spain; CIBER (Centros de Investigación Biomédica en Red) in Epidemiology and Public Health, Spain.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Comas
authors.affiliation: Molecular Mycobacteriology, Borstel, Germany; German Centre for Infection Research, Research Centre Borstel, Borstel, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Feuerriegel
authors.affiliation: Molecular Mycobacteriology, Borstel, Germany; German Centre for Infection Research, Research Centre Borstel, Borstel, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Niemann
authors.affiliation: Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Gagneux
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
mesh_terms: D000581:Amidohydrolases / Q000302:isolation & purification*; D000995:Antitubercular Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D011718:Pyrazinamide / Q000494:pharmacology*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D000581:Amidohydrolases
keywords: Mycobacterium tuberculosis complex; Phylogenetic diversity; Pyrazinamide resistance