title: Regulation of apoptosis by heat shock proteins.
abstract: Thermotolerance, the acquired resistance of cells to stress, is a well-established phenomenon. Studies of the key mediators of this response, the heat shock proteins (HSPs), have led to the discovery of the important roles played by these proteins in the regulation of apoptotic cell death. Apoptosis is critical for normal tissue homeostasis and is involved in diverse processes including development and immune clearance. Apoptosis is tightly regulated by both proapoptotic and antiapoptotic factors, and dysregulation of apoptosis plays a significant role in the pathophysiology of many diseases. In the recent years, HSPs have been identified as key determinants of cell survival, which can modulate apoptosis by directly interacting with components of the apoptotic machinery. Therefore, manipulation of the HSPs could represent a viable strategy for the treatment of diseases. Here, we review the current knowledge with regard to the mechanisms of HSP-mediated regulation of apoptosis.
authors.affiliation: Department of Biochemistry, Apoptosis Research Centre, Biosciences Research Building, Corrib Village, NUI Galway, Dangan, Galway, Ireland.
authors.forename: Donna
authors.initials: D
authors.lastname: Kennedy
authors.forename: Richard
authors.initials: R
authors.lastname: Jäger
authors.forename: Dick D
authors.initials: DD
authors.lastname: Mosser
authors.forename: Afshin
authors.initials: A
authors.lastname: Samali
mesh_terms: D000818:Animals; D017209:Apoptosis; D025461:Feedback, Physiological; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D006360:Heat-Shock Proteins
keywords: apoptosis; caspases; cell death; heat shock proteins; heat shock response; intrinsic pathway