title: Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome.
abstract: A 54-year-old man presented to our emergency department with fever and dyspnoea. He required vigorous haemodynamic support and mechanical ventilation for hypotensive distributive shock with hypoalbuminaemia, haemoconcentration, rhabdomyolysis and acute renal failure, consistent with idiopathic systemic capillary leak syndrome. Left lung consolidation and hypoxaemia were observed 6 days after admission. Sputum smear revealed the presence of acute angled branching hyphae, consistent with a diagnosis of invasive pulmonary aspergillosis. Antifungal therapy was administered and mechanical ventilation discontinued on day 66. The patient recovered and was discharged from the hospital on day 185.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Kyoto Medical Center, Kyoto-shi, Kyoto, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hayama
authors.affiliation: Department of Emergency and Critical Care Medicine, National Hospital Organization Kyoto Medical Center, Kyoto-shi, Kyoto, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shime
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Kyoto Medical Center, Kyoto-shi, Kyoto, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Mio
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D019559:Capillary Leak Syndrome / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D011859:Radiography
chemical_list: D000935:Antifungal Agents