title: A temporary compendium of thyroid hormone target genes in brain.
abstract: BACKGROUND
  Thyroid hormone controls a number of developmental and physiological processes in the brain by directly acting on gene expression. Transcriptome analyses in rodent identified a number of thyroid hormone regulated genes in several brain areas at different stages. Genome wide analysis of chromatin occupancy in a neural cell line also identified a subset of genes which transcription is likely to be directly regulated by thyroid hormone receptors in neurons. However, the abundance of these data and apparent discrepancies between studies brought some confusion.
  
  
  RESULTS
  We present here a meta-analysis of available data to identify recurrent themes in thyroid hormone action in brain cells. This provides a curated list of 734 regulated genes in rodent brain, and highlights a small number of likely direct target genes. Some of these genes are also regulated in amphibians during metamorphosis. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, INRA, École Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: F
authors.initials: F
authors.lastname: Chatonnet
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, INRA, École Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France. Electronic address: Frederic.flamant@ens-lyon.fr.
authors.forename: F
authors.initials: F
authors.lastname: Flamant
authors.affiliation: Instituto de Investigaciones Biomédicas, Center for Biomedical Research on Rare Diseases (Ciberer), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Morte
mesh_terms: D000663:Amphibians / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D050437:Genes, Developmental; D006801:Humans; D009434:Neural Pathways / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D012377:Rodentia / Q000235:genetics / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones
keywords: Cistrome; Nuclear receptors; Thyroid hormone; Transcriptome