title: Cytogenetic analysis of 6,142 amniocentesis cases: A 6-year single centre experience.
abstract: The aim of our study was to evaluate the incidences and chromosomal abnormality detection rates of various indications for genetic amniocentesis. We retrospectively analysed 6,142 amniocentesis cases performed in a single centre between January 2007 and April 2013. We assessed the indications for prenatal diagnosis, fetal karyotypes, maternal ages, fetal ultrasound findings and maternal serum screening results. The most common indication for genetic amniocentesis was an abnormal maternal serum-screening test (36.6%), followed by advanced maternal age (28%), advanced maternal age and an abnormal maternal serum screening test (14.9%) and abnormal ultrasound findings (11.2%). The highest positive predictive values obtained from the indications included abnormal ultrasound findings and abnormal maternal serum screening test (12.9%) and advanced maternal age (12.2%). Although advanced maternal age and abnormal maternal serum screening tests were the most common indicators, their association with abnormal ultrasound findings should be identified to increase the efficacy of genetic amniocentesis.
authors.affiliation: Department of Perinatology, Izmir Tepecik Training and Research Hospital , Izmir , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ekin
authors.forename: C
authors.initials: C
authors.lastname: Gezer
authors.forename: C E
authors.initials: CE
authors.lastname: Taner
authors.forename: M
authors.initials: M
authors.lastname: Ozeren
authors.forename: M E
authors.initials: ME
authors.lastname: Avci
authors.forename: I
authors.initials: I
authors.lastname: Uyar
authors.forename: I E
authors.initials: IE
authors.lastname: Ertas
mesh_terms: D000649:Amniocentesis / Q000706:statistics & numerical data*; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D014421:Turkey
keywords: Amniocentesis; chromosome aberrations; cytogenetic analysis; prenatal diagnosis; ultrasonography