title: Effect of lycopene in the treatment of periodontal disease: a clinical study.
abstract: OBJECTIVE
  Several epidemiologic studies have suggested a role of tomato products in decreasing the risk of the development of diseases related to oxidative stress (cancer and other chronic diseases). Oxidative stress may result in periodontal tissue damage either directly or indirectly. Lycopene, a powerful antioxidant and the main carotenoid in tomato products possesses the greatest quenching ability of singlet oxygen among the various carotenoids and is effective in protecting blood lymphocytes from NOO-radical damage. Hence, the aim of the present study is to compare the effect of systemically administered lycopene as an adjunct to scaling and root planing in patients with gingivitis and periodontitis.
  
  
  METHODS
  Twenty systemically healthy patients were involved in a randomized, double-blind, parallel study and based on their clinical signs were divided into two groups of mild to moderate periodontitis (A) and moderate gingivitis (B). The subjects under the groups A and B were randomly distributed between the two treatment groups: test group (n = 5), 4 mg lycopene/day for 2 weeks with oral prophylaxis (full mouth scaling and root planing (SRP) completed within 24 hours) and controls (n = 5), receiving only oral prophylaxis. Pre- and post-therapeutic periodontal parameters were evaluated.
  
  
  RESULTS
  In group A, statistically significant improvement in CAL was reported in test group as compared to control group. In group B, the difference between pretreatment and post-treatment bleeding on probing scores was found to be statistically non-significant in both groups.
  
  
  CONCLUSIONS
  Results show that lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.
  
  
  CONCLUSIONS
  Modulation of the free radical production seems to be essential for the inhibition of tissue destruction, and treatment with antioxidants, like lycopene, which is the most potent among them will block the production of free ROS or its effects might prove to be therapeutically valuable.
authors.affiliation: Professor, Department of Periodontics, KLE Society's Institute of Dental Sciences, 20, Yeshwanthpur Suburb, 2nd Stage, Tumkur Road, Bengaluru, Karnataka-560022, India, Phone: 996010380, e-mail: doc_sphoo@yahoo.com.
authors.forename: Sphoorthi Anup
authors.initials: SA
authors.lastname: Belludi
authors.affiliation: Postgraduate Student, Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
authors.forename: Shiras
authors.initials: S
authors.lastname: Verma
authors.affiliation: Professor, Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Banthia
authors.affiliation: Professor, Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Bhusari
authors.affiliation: Senior Lecturer, Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
authors.forename: Simran
authors.initials: S
authors.lastname: Parwani
authors.affiliation: Postgraduate Student, Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Kedia
authors.affiliation: Senior Scientist, Department of Agriculture, IARI Regional Station Indore, Madhya Pradesh, India.
authors.forename: S V
authors.initials: SV
authors.lastname: Saiprasad
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D012534:Dental Scaling / Q000379:methods; D004311:Double-Blind Method; D005609:Free Radicals / Q000037:antagonists & inhibitors; D005884:Gingival Hemorrhage / Q000628:therapy; D005891:Gingivitis / Q000628:therapy*; D006801:Humans; D000077276:Lycopene; D017622:Periodontal Attachment Loss / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors; D016745:Root Planing / Q000379:methods
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D002338:Carotenoids; D000077276:Lycopene