title: A tale of two models: mouse and zebrafish as complementary models for lymphatic studies.
abstract: Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.
authors.affiliation: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Jun-Dae
authors.initials: JD
authors.lastname: Kim
authors.affiliation: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Jin
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism; D042601:Lymphatic Vessels / Q000502:physiology*; D008209:Lymphedema / Q000503:physiopathology* / Q000628:therapy; D051379:Mice; D023421:Models, Animal; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D015027:Zebrafish
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: lymphatic endothelial cell (LEC); lymphatic vessels; lymphedema; zebrafish