title: Post-transcriptional RNA regulons affecting cell cycle and proliferation.
abstract: The cellular growth cycle is initiated and maintained by punctual, yet agile, regulatory events involving modifications of cell cycle proteins as well as coordinated gene expression to support cyclic checkpoint decisions. Recent evidence indicates that post-transcriptional partitioning of messenger RNA subsets by RNA-binding proteins help physically localize, temporally coordinate, and efficiently translate cell cycle proteins. This dynamic organization of mRNAs encoding cell cycle components contributes to the overall economy of the cell cycle consistent with the post-transcriptional RNA regulon model of gene expression. This review examines several recent studies demonstrating the coordination of mRNA subsets encoding cell cycle proteins during nuclear export and subsequent coupling to protein synthesis, and discusses evidence for mRNA coordination of p53 targets and the DNA damage response pathway. We consider how these observations may connect to upstream and downstream post-transcriptional coordination and coupling of splicing, export, localization, and translation. Published examples from yeast, nematode, insect, and mammalian systems are discussed, and we consider genetic evidence supporting the conclusion that dysregulation of RNA regulons may promote pathogenic states of growth such as carcinogenesis.
authors.affiliation: Department of Molecular Genetics & Microbiology, Duke University Medical Center, Box 3020, Durham, NC 27710, USA.
authors.forename: Jeff G
authors.initials: JG
authors.lastname: Blackinton
authors.affiliation: Department of Molecular Genetics & Microbiology, Duke University Medical Center, Box 3020, Durham, NC 27710, USA. Electronic address: keene001@mc.duke.edu.
authors.forename: Jack D
authors.initials: JD
authors.lastname: Keene
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D004249:DNA Damage; D015870:Gene Expression; D006801:Humans; D034622:RNA Interference; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D018085:Regulon
chemical_list: D012333:RNA, Messenger
keywords: Cancer; DNA damage; Posttranscriptional regulation; RNA-binding proteins; Translational control; p53