title: Evaluating the optimal timing of revascularisation in patients with transient ST-segment elevation myocardial infarction: rationale and design of the TRANSIENT Trial.
abstract: Patients with chest pain and a prehospital ST-segment elevation myocardial infarction (STEMI) are preferably treated with immediate percutaneous coronary intervention (PCI). However, patients with normalization of symptoms and ST-segment elevation upon hospital arrival (transient STEMI) received inconsistent therapy due to logistic reasons and the absence of evidence or explicit guidelines. In this trial, the optimal timing of coronary angiography and subsequent revascularisation is investigated in patients presenting with transient STEMI. In this prospective, multicentre, randomized controlled clinical trial, 142 consecutive patients with initially acute chest pain and STEMI, whose symptoms and ST-segment elevation resolve upon admission, are randomized to immediate intervention or a delayed intervention. Primary outcome is infarct size measured at 4 days determined by cardiovascular magnetic resonance. Secondary outcomes are left ventricular function and volumes, myocardial salvage and microvascular injury at baseline; the change in left ventricular function, volumes and infarct size at 4 months; and major adverse cardiac events at 4 and 12 months. The TRANSIENT Trial evaluates whether a delayed invasive strategy (according to NSTEMI-guidelines) is superior to an immediate invasive strategy (according to STEMI-guidelines) in patients with a transient STEMI.
authors.affiliation: Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands, j.lemkes@vumc.nl.
authors.forename: Jorrit
authors.initials: J
authors.lastname: Lemkes
authors.forename: Robin
authors.initials: R
authors.lastname: Nijveldt
authors.forename: Aernout M
authors.initials: AM
authors.lastname: Beek
authors.forename: Paul
authors.initials: P
authors.lastname: Knaapen
authors.forename: Alexander
authors.initials: A
authors.lastname: Hirsch
authors.forename: Joost
authors.initials: J
authors.lastname: Meijers
authors.forename: Cor P
authors.initials: CP
authors.lastname: Allaart
authors.forename: Albert
authors.initials: A
authors.lastname: van Rossum
authors.forename: Niels
authors.initials: N
authors.lastname: van Royen
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome