title: An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease.
abstract: The complement receptor 1 (CR1) rs6656401 polymorphism was first identified to be associated with Alzheimer's disease (AD) in European ancestry. However, the following studies reported weak or no significant association in Chinese, Japanese, Korean, African-American, Polish, and Canadian populations. We think that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous genome-wide association studies (GWAS) in European ancestry or the genetic heterogeneity of the rs6656401 polymorphism in different populations. Here, we reevaluated this association using the relatively large-scale samples from previous 24 studies (N = 85,939, 30,100 cases and 55,839 controls) by searching the PubMed, AlzGene, and Google Scholar databases. Using additive model, we did not identify significant heterogeneity among the 24 studies. We observed significant association between the rs6656401 polymorphism and AD in pooled populations (P = 1.82E-26, odds ratio (OR) = 1.18, 95 % confidence interval (CI) 1.15-1.22). In subgroup analysis, we identified significant results in East Asian population with P = 5.00E-04, OR = 1.31, 95 % CI 1.13-1.52. To our knowledge, this is the first meta-analysis to investigate the association between rs6656401 polymorphism and AD in East Asian, African-American, Canadian, and European populations. Our analysis further supports previous findings that the CR1 rs6656401 polymorphism contributes to AD susceptibility. We believe that our findings will be very useful for future genetic studies on AD.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Shen
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Yongshuai
authors.initials: Y
authors.lastname: Jiang
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
authors.forename: Liangcai
authors.initials: L
authors.lastname: Zhang
authors.forename: Fujun
authors.initials: F
authors.lastname: Li
authors.forename: Guoda
authors.initials: G
authors.lastname: Ma
authors.forename: Zugen
authors.initials: Z
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics; D017463:Receptors, Complement 3b / Q000235:genetics*
chemical_list: C509991:CR1 protein, human; D017463:Receptors, Complement 3b