title: Cytotoxicity and antimicrobial activity of the essential oil from Satureja montana subsp. pisidica (Lamiceae).
abstract: The antimicrobial and cytotoxic activities of the essential oil of Satureja montana ssp. pisidica from two localities (mountains Korab and Galicica) were studied. Forty-nine components were identified in the each sample. Oxygenated monoterpene hydrocarbons were the major compounds: carvacrol, thymol, carvacrol methyl ether and beta-linalool. Both tested essential oils showed very high and similar antimicrobial activity. Minimal inhibitory concentrations ranged from 12.5 microg/mL against S. epidermidis to 50 microg/mL against P. aeruginosa and C. albicans. The cytotoxic effect of the essential oils was tested against MDA-MB-361, MDA-MB-453, HeLa, LS174 and MRC5 cells. The essential oil from Korab demonstrated significantly better results than the oil from Galicica, particularly against HeLa and MDA-MB-453 cell lines, with IC50 values of 63.5 and 72.3 microg/mL, while the oil from Galicica was the most active on the human epithelial cervical cancer HeLa cells (IC50 99.7 microg/mL).
authors.forename: Tatjana
authors.initials: T
authors.lastname: Kundaković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Stanojković
authors.forename: Branka
authors.initials: B
authors.lastname: Kolundzija
authors.forename: Stevan
authors.initials: S
authors.lastname: Marković
authors.forename: Branka
authors.initials: B
authors.lastname: Sukilović
authors.forename: Marina
authors.initials: M
authors.lastname: Milenković
authors.forename: Branislava
authors.initials: B
authors.lastname: Lakusić
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D031362:Satureja / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010938:Plant Oils