title: Transcriptional regulation of graded Hedgehog signaling.
abstract: The Hedgehog (Hh) pathway plays conserved roles in regulating a diverse spectrum of developmental processes. In some developmental contexts, a gradient of Hh protein specifies multiple cell types in a dose-dependent fashion, thereby acting as a morphogen. Hh signaling ultimately acts on the transcriptional level through GLI proteins. In the presence of Hh signaling full length GLI proteins act as transcriptional activators of target genes. Conversely, in the absence of Hh, GLI proteins act as transcriptional repressors. This review will highlight mechanisms contributing to how graded Hh signaling might translate to differential GLI activity and be interpreted into distinct transcriptional responses.
authors.affiliation: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway Stop A4800, Austin, TX 78712, USA.
authors.forename: Kristin N
authors.initials: KN
authors.lastname: Falkenstein
authors.affiliation: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway Stop A4800, Austin, TX 78712, USA. Electronic address: svokes@austin.utexas.edu.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Vokes
mesh_terms: D000818:Animals; D001665:Binding Sites; D019521:Body Patterning; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins / Q000502:physiology*; D009928:Organ Specificity; D010766:Phosphorylation; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D053823:Hedgehog Proteins
keywords: Development; Gli; Hedgehog; Morphogen