title: Photothermally targeted thermosensitive polymer-masked nanoparticles.
abstract: The targeted delivery of therapeutic cargos using noninvasive stimuli has the potential to improve efficacy and reduce off-target effects (toxicity). Here, we demonstrate a targeting mechanism that uses a thermoresponsive copolymer to mask a peptide ligand that binds a widely distributed receptor (integrin β1) on the surface of silica core-gold shell nanoparticles. The nanoparticles convert NIR light into heat, which causes the copolymer to collapse, exposing the ligand peptide, allowing cell binding. The use of NIR light could allow targeting of plasmonic nanoparticles deep within tissues. This approach could be extended to a variety of applications including photothermal therapy and drug delivery.
authors.affiliation: Laboratory for Biomaterials and Drug Delivery, §Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: Aoune
authors.initials: A
authors.lastname: Barhoumi
authors.forename: Weiping
authors.initials: W
authors.lastname: Wang
authors.forename: David
authors.initials: D
authors.lastname: Zurakowski
authors.forename: Robert S
authors.initials: RS
authors.lastname: Langer
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kohane
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry* / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D019012:Integrin beta1; D010455:Peptides; C052970:poly-N-isopropylacrylamide; D006046:Gold