title: Proteus syndrome: A rare cause of gigantic limb.
abstract: A congenital disorder with variable manifestations, including partial gigantism of the hands and feet with hypertrophy of soles, nevi, hemihypertrophy, gynecomastia, macrocephaly and other skull abnormalities, and abdominal lipomatosis. The cause is unknown, although a genetic origin, generally of autosomal-dominant transmission, has been conjectured. Symptoms can be treated, but there is no known cure. We present the case of a young male with grotesque overgrowth of the right lower limb, splenomegaly and multiple nevi. Angiography revealed venous malformation within the limb. The findings are in conformity to the criteria for the Proteus syndrome.
authors.affiliation: Department of Medicine, Nil Ratan Sarkar Medical College, Kolkata, India.
authors.forename: Nandini
authors.initials: N
authors.lastname: Chakrabarti
authors.affiliation: Department of Pharmacology, KPC Medical College, Kolkata, India.
authors.forename: Chandan
authors.initials: C
authors.lastname: Chattopadhyay
authors.affiliation: Department of Medicine, Nil Ratan Sarkar Medical College, Kolkata, India.
authors.forename: Majhi
authors.initials: M
authors.lastname: Bhuban
authors.affiliation: Midnapur Medical College and Hospital, Midnapur, India.
authors.forename: Salil Kumar
authors.initials: SK
authors.lastname: Pal
keywords: Gigantic limb; Proteus; nevi; overgrowth; venous malformation