title: Sucrose/Glucose molecular alloys by cryomilling.
abstract: We report here for the first time a series of amorphous sucrose/glucose molecular alloys prepared by cryomilling. Differential scanning calorimetry, X-ray powder diffraction and solution proton nuclear magnetic resonance showed that cryomilling drives a direct transformation from a two-phase mixture of crystalline sucrose and glucose, to a single-phase amorphous sucrose/glucose molecular alloy. The molecular alloys displayed a single Tg which varied linearly with composition. The effect of atmospheric moisture and the possibility of localised melting of the material because of milling-related friction were also discussed.
authors.affiliation: University of Nottingham, School of Pharmacy, Nottingham, Nottinghamshire, United Kingdom.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Megarry
authors.affiliation: AstraZeneca, Product Development, Macclesfield, Cheshire, United Kingdom. Electronic address: jonathan.burley@nottingham.ac.uk.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Booth
authors.affiliation: University of Nottingham, School of Pharmacy, Nottingham, Nottinghamshire, United Kingdom.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Burley
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D005079:Excipients / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D044367:Phase Transition; D013395:Sucrose / Q000737:chemistry*; D044366:Transition Temperature; D014961:X-Ray Diffraction
chemical_list: D005079:Excipients; D013395:Sucrose; D005947:Glucose
keywords: X-ray powder diffractometry; amorphous; calorimetry (DSC); materials science; milling