title: KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods.
abstract: BACKGROUND
  The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with chronic kidney disease stages 1 to 5 (predialysis).
  
  
  METHODS
  Nine nephrology centers in major university hospitals throughout Korea will enroll approximately 2,450 adults with chronic kidney disease over a 5-year period from 2011 to 2015. The participating individuals will be monitored for approximately 10 years until death or until end-stage renal disease occurs. The subjects will be classified into subgroups based on the following specific causes of chronic kidney disease: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, and others. The eligible subjects will be evaluated at baseline for socio-demographic information, detailed personal/family history, office BP, quality of life, and health behaviors. After enrollment in the study, thorough assessments, including laboratory tests, cardiac evaluation and radiologic imaging, will be performed according to the standardized protocol. The biospecimen samples will be collected regularly. A renal event is defined by >50% decrease in estimated GFR (eGFR) from the baseline values, doubling of serum creatinine, or end-stage renal disease. The primary composite outcome consists of renal events, cardiovascular events, and death. As of September 2013, 1,470 adult chronic kidney disease subjects were enrolled in the study, including 543 subjects with glomerulonephritis, 317 with diabetic nephropathy, 294 with hypertensive nephropathy and 249 with polycystic kidney disease.
  
  
  CONCLUSIONS
  As the first large-scale chronic kidney disease cohort study to be established and maintained longitudinally for up to 10 years, the KNOW-CKD will help to clarify the natural course, complication profiles, and risk factors of Asian populations with chronic kidney disease.
  
  
  BACKGROUND
  No. NCT01630486 at http://www.clinicaltrials.gov.
authors.forename: Kook-Hwan
authors.initials: KH
authors.lastname: Oh
authors.forename: Sue Kyung
authors.initials: SK
authors.lastname: Park
authors.forename: Hayne Cho
authors.initials: HC
authors.lastname: Park
authors.forename: Ho Jun
authors.initials: HJ
authors.lastname: Chin
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Chae
authors.forename: Kyu Hun
authors.initials: KH
authors.lastname: Choi
authors.forename: Seung Hyeok
authors.initials: SH
authors.lastname: Han
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Yoo
authors.forename: Kyubeck
authors.initials: K
authors.lastname: Lee
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Hwang
authors.forename: Soo Wan
authors.initials: SW
authors.lastname: Kim
authors.forename: Yeong Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Kang
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Park
authors.forename: Joongyub
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University, 101 Daehakro, Chongno Gu, Seoul 110-744, Korea. curie@snu.ac.kr.
authors.forename: Curie
authors.initials: C
authors.lastname: Ahn
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis / Q000401:mortality*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000401:mortality*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000401:mortality*; D056910:Republic of Korea / Q000453:epidemiology; D012107:Research Design; D012307:Risk Factors; D015996:Survival Rate