title: Assessment of mean platelet volume and soluble CD40 ligand levels in patients with non-dipper hypertension, dippers and normotensives.
abstract: Abstract Objective: Patients with a lack of nocturnal decline in blood pressure (BP) are at an increased risk for cardiovascular events. Mean platelet volume (MPV) and soluble CD40 ligand (sCD40L) are accepted biomarkers of platelet activation and considered as a risk factor for cardiovascular disease. The aim of this study was to determine whether MPV and sCD40L levels are higher in non-dipper hypertensive (NDHT) patients than in dipper hypertensive (DHT) patients and healthy controls.
  
  
  METHODS
  124 consecutive patients were included to this study. Patients were divided into three groups: NDHT patient group [n = 43; mean age 51.8 ± 6.6; 31 males (72.1%)]; DHT patient group [n = 41; mean age 50.2 ± 7.3; 22 males (53.7%)]; and normotensive group [n = 40; mean age 49.9 ± 6.7; 22 males (55%)]. Physical examination, laboratory work-up and 24-h ABPM were performed for all participants.
  
  
  RESULTS
  The sCD40L and MPV levels were significantly higher in the NDHT group than in the DHT and normotensive groups (p < 0.05). In correlation analysis, MPV, 24-h systolic blood pressure (SBP), 24-h diastolic blood pressure (DBP), night-time SBP and night-time DBP were positively correlated with sCD40L.
  
  
  CONCLUSIONS
  Our study demonstrated that MPV and sCD40L levels were significantly higher in NDHT patients compared to DHT and normotensive patients. sCD40L levels were positively correlated with MPV, 24-h SBP, 24-h DBP, night-time SBP and night-time DBP.
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital , Istanbul , Turkey .
authors.forename: Ozgur
authors.initials: O
authors.lastname: Surgit
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erturk
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akgul
authors.forename: Hamdi
authors.initials: H
authors.lastname: Pusuroglu
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Korkmaz
authors.forename: Nilgun
authors.initials: N
authors.lastname: Isiksacan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Fatih
authors.initials: F
authors.lastname: Uzun
authors.forename: Ender
authors.initials: E
authors.lastname: Ozal
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Eksik
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000379:methods; D023201:CD40 Ligand / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D012307:Risk Factors
chemical_list: D023201:CD40 Ligand
keywords: Mean platelet volume; non-dipper hypertension; soluble CD40 ligand