title: Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.
abstract: We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.
authors.affiliation: Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Prigitano
authors.forename: Maria Carmela
authors.initials: MC
authors.lastname: Esposito
authors.forename: Massimo
authors.initials: M
authors.lastname: Cogliati
authors.forename: Lucia
authors.initials: L
authors.lastname: Pitzurra
authors.forename: Concetta
authors.initials: C
authors.lastname: Santamaria
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Tortorano
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D002177:Candidiasis / Q000382:microbiology*; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics*; D016469:Fungemia / Q000382:microbiology*; D005964:Glucosyltransferases / Q000235:genetics*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D005964:Glucosyltransferases