title: Gestational diabetes outcome in a single center study: higher BMI in children after six months.
abstract: The aim of the study was to examine obstetric outcomes and metabolic disorders in patients with gestational diabetes mellitus (GDM) and their offspring compared to mothers without GDM and their offspring. We performed a retrospective single center cohort study of mothers with GDM using a questionnaire with items concerning the maternal medical history, neonatal complications, and child development. Mothers with gestational diabetes (GDM; n=130) and those with normal glucose tolerance (NGT; n=77) were recruited. GDM mothers were older (37.58 years vs. 34.32 years, p<0.0001) and had a greater body mass index (25.18 kg/m² vs. 23.37 kg/m², p<0.01). There were no significant differences regarding the mean birth weight, the frequency of Cesarean sections, and the prevalence of macrosomia (> 4 000 g). At follow-up (pediatric U5 screening visit after 6 months of birth) children of mothers with GDM had significantly higher BMI than the children of the NGT group (17.07 kg/m² vs. 16.59 kg/m², p=0.042). GDM women in need of insulin therapy during pregnancy had higher BMI than dieting GDM mothers and experienced more frequently an operative vaginal delivery (17.95% vs. 6.17%, OR 3.23, p=0.04). We found less significant differences between GDM mothers with treatment of impaired glucose tolerance and NGT mothers concerning the neonatal outcome than expected. Despite higher BMI of the GDM group's offspring at follow-up U5 visit, the children did not show any other development disorder. In conclusion treatment of GDM could minimize the frequency of obstetric and neonatal complications in this risk group.
authors.affiliation: Division Endocrinology & Diabetology, Department of Internal Medicine 1 and Department of Obstetrics of the University Hospital, Goethe-University, Frankfurt am Main, Germany.
authors.forename: A B
authors.initials: AB
authors.lastname: König
authors.affiliation: Division Endocrinology & Diabetology, Department of Internal Medicine 1 and Department of Obstetrics of the University Hospital, Goethe-University, Frankfurt am Main, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Junginger
authors.affiliation: Division Endocrinology & Diabetology, Department of Internal Medicine 1 and Department of Obstetrics of the University Hospital, Goethe-University, Frankfurt am Main, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Reusch
authors.affiliation: Division Endocrinology & Diabetology, Department of Internal Medicine 1 and Department of Obstetrics of the University Hospital, Goethe-University, Frankfurt am Main, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Louwen
authors.affiliation: Division Endocrinology & Diabetology, Department of Internal Medicine 1 and Department of Obstetrics of the University Hospital, Goethe-University, Frankfurt am Main, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Badenhoop
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002657:Child Development; D036861:Delivery, Obstetric; D016640:Diabetes, Gestational / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D011247:Pregnancy; D013997:Time Factors
chemical_list: D007328:Insulin