title: Does stress induce bowel dysfunction?
abstract: Psychological stress is known to induce somatic symptoms. Classically, many gut physiological responses to stress are mediated by the hypothalamus-pituitary-adrenal axis. There is, however, a growing body of evidence of stress-induced corticotrophin-releasing factor (CRF) release causing bowel dysfunction through multiple pathways, either through the HPA axis, the autonomic nervous systems, or directly on the bowel itself. In addition, recent findings of CRF influencing the composition of gut microbiota lend support for the use of probiotics, antibiotics, and other microbiota-altering agents as potential therapeutic measures in stress-induced bowel dysfunction.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 3912 Taubman Center, SPC 5362, 1500 East Medical Center Drive, Ann Arbor, MI, USA.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chang
authors.forename: Mohamad
authors.initials: M
authors.lastname: El-Zaatari
authors.forename: John Y
authors.initials: JY
authors.lastname: Kao
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000378:metabolism / Q000503:physiopathology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D007410:Intestinal Diseases / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology; D019936:Probiotics / Q000627:therapeutic use; D012307:Risk Factors; D015398:Signal Transduction; D013315:Stress, Psychological / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D018836:Inflammation Mediators; D003346:Corticotropin-Releasing Hormone
keywords: NLRP6; bowel dysfunction; irritable bowel syndrome; microbiota; stress