title: The status of radioimmunotherapy in CD20+ non-Hodgkin's lymphoma.
abstract: Rituximab, the CD20-directed antibody, has become a standard component of treatment regimens for patients with B cell non-Hodgkin's lymphoma (NHL). The use of rituximab has resulted in greatly improved response and survival rates with less toxicity relative to standard chemotherapeutic regimes. However, relapse and recurrence is common, particularly in indolent varieties which remain incurable, requiring alternate therapeutic options. The subsequent coupling of β-emitting isotopes such as (131)I and (90)Y to anti-CD20 monoclonal antibodies (mAbs), including rituximab, has been steadily growing over the last decade and demonstrates even greater therapeutic efficacy with more durable responses. (177)Lutetium-labelled rituximab offers a number of convenient advantages over (131)I and (90)Y anti-CD20 mAbs for treatment of NHL, and a number of alpha-emitting isotopes lie at the frontier of consolidation therapy for residual, micrometastatic disease.
authors.affiliation: Discipline of Medical Radiations, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC, 3083, Australia, evan.read@rmit.edu.au.
authors.forename: Evan D
authors.initials: ED
authors.lastname: Read
authors.forename: Peter
authors.initials: P
authors.lastname: Eu
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Little
authors.forename: Terrence J
authors.initials: TJ
authors.lastname: Piva
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D058990:Molecular Targeted Therapy / Q000379:methods*; D016499:Radioimmunotherapy / Q000379:methods*; D000069283:Rituximab / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000069283:Rituximab