title: The diagnostics of colorectal cancer.
abstract: Colorectal cancer (CRC) is one of the most frequent human malignant neoplasms. CRC has an estimated incidence of more than 1,000,000 new cases annually worldwide. Approximately one out of three people who develop CRC dies from the disease. Furthermore, CRC often affects inhabitants of industrialized countries in comparison to less developed countries. Several markers of colon cancer, including CEA, CA-19-9, TPS, TAG-72 and lysosomal hydrolases, have been identified and are now being adopted in routine clinical practice. Increased values of these markers are often the first signal of recurrence or metastases, which is useful in prediction and prognosis of clinical outcome of patients with CRC. Determination of the activity of lysosomal exoglycosidases in body fluids may bring some hope of improving diagnosis of colorectal cancer. However, it has to be remembered that currently the most effective diagnostic method of CRC is endoscopy.
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Swiderska
authors.affiliation: 1 Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Choromańska
authors.affiliation: Department of Emergency Medicine and Disasters, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Dąbrowska
authors.affiliation: Department of Emergency Medicine and Disasters, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Emilia
authors.initials: E
authors.lastname: Konarzewska-Duchnowska
authors.affiliation: SKN Dental Biochemistry at the Department of Conservative Dentistry, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Choromańska
authors.affiliation: Department of Restorative Dentistry, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Szczurko
authors.affiliation: 1 Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Myśliwiec
authors.affiliation: 1 Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Dadan
authors.affiliation: Department of Emergency Medicine and Disasters, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Jerzy Robert
authors.initials: JR
authors.lastname: Ladny
authors.affiliation: Medical College of the Universal Education Society, Lomza, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
keywords: colorectal cancer; endoscopy; lysosomal exoglycosidases; tumor markers