title: Nephrotic-range proteinuria and interstitial nephritis associated with the use of a topical loxoprofen patch.
abstract: A 76-year-old woman with a history of lumbar fracture and marked proteinuria, bilateral pitting edema, malaise and pruritus was referred for an evaluation of an impaired renal function. A renal biopsy led to a tentative diagnosis of acute interstitial nephritis (AIN) with minimal change disease caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Following the discontinuation of oral NSAIDs, the patient's symptoms disappeared spontaneously. However, nephrotic-range proteinuria relapsed one month after discharge, following loxoprofen patch use. The withdrawal of the topical loxoprofen patches once again resulted in the disappearance of all symptoms. This is the first case report of nephrotic-range proteinuria and AIN secondary to topical NSAID patch use.
authors.affiliation: Department of Nephrology, Yokosuka Kyosai Hospital, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Aoyagi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nagahama
authors.forename: Yu
authors.initials: Y
authors.lastname: Yajima
authors.forename: Chisato
authors.initials: C
authors.lastname: Yamamura
authors.forename: Yohei
authors.initials: Y
authors.lastname: Arai
authors.forename: Suguru
authors.initials: S
authors.lastname: Hirasawa
authors.forename: Shota
authors.initials: S
authors.lastname: Aki
authors.forename: Naoto
authors.initials: N
authors.lastname: Inaba
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Teiichi
authors.initials: T
authors.lastname: Tamura
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000473:pathology; D010666:Phenylpropionates / Q000008:administration & dosage / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced*; D014463:Ultrasonography
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; C040656:loxoprofen