title: Brainstem and spinal reflex studies in patients with primary progressive freezing of gait.
abstract: Our aim was to investigate the extent and pattern of involved pathways using brainstem and spinal reflexes by comparing primary progressive freezing of gait (PPFOG) progressive supranuclear palsy (PSP) with FOG. Seven patients with PPFOG and age and sex matched seven PSP patients and 16 healthy subjects were included in the study. All subjects underwent blink reflex (BR), trigemino-cervical reflex (TCR), auditory startle reflex (ASR) and long latency flexor reflex (LLFR) investigations under the same conditions. All three groups had normal BR latencies. ASR probability was lowest in the PSP group and was highest in PPFOG (p=0.005). The presence rate of TCR was lowest in PSP and it was highest in PPFOG (p=0.007 for SC and p=0.023 for SCM). The presence rate and amplitude of LLFR (R II) were decreased in the PSP group (p=0.010 and p=0.031, respectively) whereas it was in a continuous pattern in some of PPFOG patients. ASR, TCR and LLFR were all inhibited in PSP and we suggest that suppression of all three reflexes is probably related to degeneration of brainstem reticular formation and basal ganglia connections. However, interestingly, in PPFOG, excitabilities of ASR and TCR circuits are increased suggesting loss of pathways mediating suprasegmental control.
authors.affiliation: Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Meral E
authors.initials: ME
authors.lastname: Kızıltan
authors.affiliation: Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: draysegulgunduz@yahoo.com.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Gunduz
authors.affiliation: Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Gunes
authors.initials: G
authors.lastname: Kızıltan
authors.affiliation: Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Anıl
authors.initials: A
authors.lastname: Tekeoğlu
authors.affiliation: Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Melis
authors.initials: M
authors.lastname: Sohtaoğlu
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D001933:Brain Stem / Q000503:physiopathology*; D004594:Electrophysiology; D005260:Female; D020233:Gait Disorders, Neurologic / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012018:Reflex / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*; D013494:Supranuclear Palsy, Progressive / Q000150:complications / Q000473:pathology*
keywords: Auditory startle response; Blink reflex; Lower limb flexor reflex; Primary progressive freezing of gait; Progressive supranuclear palsy with freezing of gait; Trigemino-cervical reflex