title: Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma.
abstract: The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirect ELISA using synthetic peptides that mimic SV-40 antigens, was employed to detect antibodies against SV-40 in serum samples from UM patients. Our report indicates a significant higher prevalence of antibodies against SV-40 capsid protein antigens in serum samples from UM patients compared to controls. Our data suggest an association between UM and SV-40, indicating that patients affected by uveal melanoma tested SV-40-positive could be treated by innovative therapies.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bononi
authors.forename: Paolo
authors.initials: P
authors.lastname: Perri
authors.forename: Alice
authors.initials: A
authors.lastname: Begnardi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Martini
authors.forename: Elisa
authors.initials: E
authors.lastname: Mazzoni
authors.forename: Silvia
authors.initials: S
authors.lastname: Bosi
authors.forename: Silvia
authors.initials: S
authors.lastname: Pietrobon
authors.forename: Adolfo
authors.initials: A
authors.lastname: Sebastiani
authors.affiliation: Department of Biomedical Sciences and Surgical Specialities, School of Medicine, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy. tgm@unife.it.
authors.forename: Mauro
authors.initials: M
authors.lastname: Tognon
authors.forename: Fernanda
authors.initials: F
authors.lastname: Martini
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D008545:Melanoma / Q000097:blood / Q000276:immunology* / Q000821:virology; D010455:Peptides / Q000276:immunology; D013539:Simian virus 40 / Q000276:immunology* / Q000502:physiology; D014604:Uveal Neoplasms / Q000097:blood / Q000276:immunology* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D010455:Peptides