title: [A comparison of minimal residual disease in children with acute lymphoblastic leukemia of different genetic abnormalities].
abstract: OBJECTIVE
  To study the changes of minimal residual disease (MRD) in children with B cell acute lymphoblastic leukemia (B-ALL) of different genetic abnormalities.
  
  
  METHODS
  Between February 2004 and April 2013, 271 newly diagnosed B-ALL pediatric patients who had finished the induction chemotherapy were enrolled in the study. The characteristics of changes in MRD in patients with different genetic abnormalities on the 15th day and at the end of the induction therapy were analyzed.
  
  
  RESULTS
  On the 15th day of the induction chemotherapy, the MRD positive proportion in patients with hyperdiploid was higher on all the three cut-off levels of MRD≥0.1%, 1% and 10% compared to patients without hyperdiploid (P<0.05), but there was no significant difference in the MRD positive proportion on the three levels of MRD between the TEL-AML1-positive and TEL-AML1-negative groups (P>0.05). On the end of induction chemotherapy, there was no significant difference in the MRD positive proportion on the three levels of MRD between the patients with and without hyperdiploid (P>0.05), neither between the BCR-ABL-positive and negative groups. The MRD positive proportion in TEL-AML1-negative patients was significantly higher than in TEL-AML1-positive patients on all three levels of MRD (P<0.05). The MRD positive proportion on two levels of MRD≥0.01% and 0.1% in E2A-PBX1-negative patients was significantly higher than in E2A-PBX1-positive patients (P<0.05).
  
  
  CONCLUSIONS
  Children with B-ALL of different genetic abnormalities have different MRD levels during, and at the end of, induction therapy. The prognostic significance of MRD may be related to the genetic abnormalities.
authors.affiliation: Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China. jiayueping@pkuph.edu.cn.
authors.forename: Shan-Ya-Mei
authors.initials: SY
authors.lastname: Huang
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Jia
authors.forename: Gui-Lan
authors.initials: GL
authors.lastname: Liu
authors.forename: Le-Ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Ai-Dong
authors.initials: AD
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018365:Neoplasm, Residual / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*