title: Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers.
abstract: Stable core-shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a hydrophilic β-cyclodextrin head; their potential to encapsulate and provide sustained release of the anticancer drug docetaxel and undergo surface post-modification with glycoligands targeting the macrophage mannose receptor is discussed.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, E-41012 Sevilla, Spain. mellet@us.es.
authors.forename: Laura
authors.initials: L
authors.lastname: Gallego-Yerga
authors.forename: Michela
authors.initials: M
authors.lastname: Lomazzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Sansone
authors.forename: Carmen
authors.initials: C
authors.lastname: Ortiz Mellet
authors.forename: Alessandro
authors.initials: A
authors.lastname: Casnati
authors.forename: José M
authors.initials: JM
authors.lastname: García Fernández
mesh_terms: D047250:Calixarenes / Q000737:chemistry* / Q000493:pharmacokinetics; D003505:Cyclodextrins / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000639:trends; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D054118:Nanospheres / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D008024:Ligands; D047250:Calixarenes