title: Treatment of diffuse subretinal fibrosis uveitis with rituximab.
abstract: Diffuse subretinal fibrosis uveitis (DUS) syndrome is a rare form of granulomatous multifocal choroiditis (MFC) characterised by enlarging areas of subretinal fibrosis (SRF) which coalesce with subsequent macular involvement and visual loss. First described by Palestine, DUS carries a poor visual prognosis despite use of high-dose corticosteroids and systemic immunosuppression. We report two cases of bilateral DUS successfully treated with rituximab. We believe given the B-cell predominance in the underlying pathogenesis of the disease, rituximab should be considered first line in the management of this potentially devastating disease.
authors.affiliation: Clinical Ophthalmology Department, NHS Grampian, Aberdeen Royal Infirmary, Aberdeen, UK.
authors.forename: Kurt Spiteri
authors.initials: KS
authors.lastname: Cornish
authors.affiliation: Clinical Ophthalmology Department, NHS Grampian, Aberdeen Royal Infirmary, Aberdeen, UK Section of Immunology, Inflammation and Infection (3I's) (Ocular Immunology), Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK.
authors.forename: Lucia
authors.initials: L
authors.lastname: Kuffova
authors.affiliation: Section of Immunology, Inflammation and Infection (3I's) (Ocular Immunology), Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK Immunology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Western Australia, Australia.
authors.forename: John V
authors.initials: JV
authors.lastname: Forrester
mesh_terms: D000293:Adolescent; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D018951:Antigens, CD20; D002833:Choroiditis / Q000175:diagnosis / Q000188:drug therapy*; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D005355:Fibrosis; D005451:Fluorescein Angiography; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000080364:Multifocal Choroiditis; D012160:Retina / Q000473:pathology*; D000069283:Rituximab; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D007155:Immunologic Factors; D000069283:Rituximab
keywords: Immunology; Inflammation; Retina