title: Increased prevalence of malignancy in adult mitochondrial disorders.
abstract: OBJECTIVE
  there are indications that patients with a mitochondrial disorder (MID) develop malignomas or benign tumors more frequently than the general population. The aims of the study were to find out if the prevalence of tumors is actually increased in MID-patients and which of the malignomas or benign tumors are the most frequent.
  
  
  METHODS
  The charts of MID-patients were retrospectively evaluated for the presence of malign or benign tumors. MID was diagnosed according to the modified Walker-criteria.
  
  
  RESULTS
  Among the 475 MID-patients screened for tumors, at least a single malignoma was found in 65 patients (13.7%), and at least a single benign tumor in 35 patients (7.4%). Among those with malignancy, 22 were men and 43 women. Among those with a malignancy, 1 had definite MID, 9 probable MID, and 55 possible MID. The most common of the malignancies was breast cancer, followed by dermatological, gynecological, and gastrointestinal malignancies. The most frequent of the benign tumors was lipoma, followed by pituitary adenoma, meningeomas, carcinoids, and suprarenal adenomas. Compared to the general population, the prevalence of malignancies and of benign tumors was markedly increased. The female preponderance was explained by the frequent maternal inheritance of MIDs.
  
  
  CONCLUSIONS
  Adult patients with a MID, particularly females, carry an increased risk to develop a malignancy or a benign tumor. Since malignancy is an important determinant for their outcome, these patients should be more accurately screened for neoplasms, not to overlook the point, at which an effective treatment can no longer be provided.
authors.affiliation: Krankenanstalt Rudolfstiftung, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Finsterer
authors.affiliation: 1st Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Krexner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000150:complications* / Q000453:epidemiology* / Q000378:metabolism; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D017382:Reactive Oxygen Species
keywords: malignancy; mitochondrial disorder; mtDNA; reactive oxidative species; tumor