title: Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.
abstract: The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.
authors.affiliation: Department of Cardiology, Children's Hospital Boston, USA.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Cardiology, Children's Hospital Boston, USA; Harvard Stem Cell Institute, Harvard University, USA. Electronic address: wpu@enders.tch.harvard.edu.
authors.forename: William T
authors.initials: WT
authors.lastname: Pu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006321:Heart / Q000503:physiopathology*; D006331:Heart Diseases / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D000090683:Hippo Signaling Pathway; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D012038:Regeneration; D012060:Rejuvenation; D015398:Signal Transduction; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D017346:Protein Serine-Threonine Kinases