title: [Role of the RIG-I-like receptors in antiviral response].
abstract: The innate nonspecific immunity is the first line of defense against viral infection. Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are two main receptor families detecting viral nucleic acid. So far, three RLR family members were characterized: RIG-I, MDA5 and LGP2. RLR constitute a family of cytoplasmic helicases, which recognized intracellular single-stranded and double-stranded RNA that is introduced to cytosol during viral infection and replication. In this work we review the current knowledge about the mechanisms of viral recognition by RIG-I-like receptors and their signaling pathways for the activation of type I interferons and pro-inflammatory cytokines synthesis.
authors.affiliation: Pracownia Wirusologii Molekularnej i Chemii Biologicznej, Instytut Biologii Medycznej PAN, Łódź
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jabłońska
authors.affiliation: Pracownia Wirusologii Molekularnej i Chemii Biologicznej, Instytut Biologii Medycznej PAN, Łódź
authors.forename: Edyta
authors.initials: E
authors.lastname: Paradowska
mesh_terms: D065767:Activation, Metabolic; D016207:Cytokines / Q000096:biosynthesis; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology; D012367:RNA, Viral / Q000276:immunology; D011971:Receptors, Immunologic; D015398:Signal Transduction / Q000276:immunology*; D025801:Ubiquitin / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D016207:Cytokines; D007370:Interferon Type I; D012367:RNA, Viral; D011971:Receptors, Immunologic; D025801:Ubiquitin; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases