title: Effect of size on biological properties of nanoparticles employed in gene delivery.
abstract: BACKGROUND
  The size of nanoparticles plays a pivotal role in determining the gene delivery efficiency.
  
  
  OBJECTIVE
  A focus on the studies done to investigate the effect of nanoparticles size on biological aspects of gene delivery.
  
  
  METHODS
  A through literature survey has been done regarding studies done to investigate the effect of nanoparticles size on uptake, transfection efficiency and biodistribution has been cited in the present review.
  
  
  CONCLUSIONS
  The gene delivery efficacy may depend on conjugation of several factors such as the chemical structure of polymers, cell type, and nanoparticle size, composition and interaction with cells.
authors.affiliation: a Department of Pharmaceutical Chemistry , Jamia Hamdard University , New Delhi , India.
authors.forename: Shashi
authors.initials: S
authors.lastname: Prabha
authors.affiliation: b Department of Biotechnology , School of Life Sciences, Central University of Rajasthan , Ajmer , Rajasthan , India.
authors.forename: Geeta
authors.initials: G
authors.lastname: Arya
authors.affiliation: c Department of Chemistry , University of Delhi , Delhi , India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
authors.affiliation: a Department of Pharmaceutical Chemistry , Jamia Hamdard University , New Delhi , India.
authors.forename: Bahar
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: b Department of Biotechnology , School of Life Sciences, Central University of Rajasthan , Ajmer , Rajasthan , India.
authors.forename: Surendra
authors.initials: S
authors.lastname: Nimesh
mesh_terms: D002460:Cell Line; D002470:Cell Survival; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004705:Endocytosis / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D010316:Particle Size; D011094:Polyethyleneimine / Q000737:chemistry; D011107:Polylysine / Q000737:chemistry; D014018:Tissue Distribution; D014168:Transferrin / Q000737:chemistry; D019076:Transgenes
chemical_list: D014168:Transferrin; D011107:Polylysine; D011094:Polyethyleneimine; D004247:DNA
keywords: biodistribution; cellular uptake; complexes; cytotoxicity; nanoparticles; transfection