title: [Severe community-acquired pneumonia admitted at the intensive care unit: main clinical and bacteriological features and prognostic factors: a Tunisian experience].
abstract: BACKGROUND
  Severe community-acquired pneumonia (SCAP) remains a major cause of death. The aim of this study was to describe the main clinical and bacteriological features and to determine predictive factors for death in patients with SCAP who were admitted in intensive care unit (ICU) in a Tunisian setting.
  
  
  METHODS
  It is a retrospective study conducted between March 2005 and December 2010 at the intensive care unit of the University Hospital of Mahdia (Tunisia). All patients hospitalized at the ICU with a SCAP diagnosis according to the American Thoracic Society criteria were included.
  
  
  RESULTS
  Two hundred and nine patients (mean age: 64±16 years, and mean SAPS II: 42±17) were included. Overall, 24% had a bacteriological diagnosis. Streptococcus pneumoniae was the most frequently detected. Use of mechanical ventilation was required in 57% of patients and 45% experimented septic shock upon admission. The mortality rate at ICU was 29% (n=60). In multivariate analysis, a septic shock at admission and the use of mechanical ventilation were both associated with death.
  
  
  CONCLUSIONS
  SCAP were associated with high mortality in the ICU.
authors.affiliation: Service de réanimation médicale, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie; Laboratoire de recherche LR12SP15, Mahdia, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Fekih Hassen
authors.affiliation: Laboratoire de microbiologie, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie. Electronic address: aniswalid_tn2003@yahoo.fr.
authors.forename: A
authors.initials: A
authors.lastname: Ben Haj Khalifa
authors.affiliation: Service de réanimation médicale, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie; Laboratoire de recherche LR12SP15, Mahdia, Tunisie.
authors.forename: N
authors.initials: N
authors.lastname: Tilouche
authors.affiliation: Service de réanimation médicale, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie; Laboratoire de recherche LR12SP15, Mahdia, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Ben Sik Ali
authors.affiliation: Service de réanimation médicale, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie; Laboratoire de recherche LR12SP15, Mahdia, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Ayed
authors.affiliation: Laboratoire de microbiologie, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Kheder
authors.affiliation: Service de réanimation médicale, CHU Tahar-Sfar de Mahdia, Mahdia 5100, Tunisie; Laboratoire de recherche LR12SP15, Mahdia, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Elatrous
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000382:microbiology* / Q000401:mortality / Q000628:therapy*; D024881:Drug Resistance, Bacterial; D005260:Female; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000401:mortality / Q000628:therapy*; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012772:Shock, Septic / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D014416:Tunisia
chemical_list: D000900:Anti-Bacterial Agents
keywords: Epidemiology; Facteurs pronostiques; Intensive care; Mortality; Mortalité; Pneumopathies communautaires sévères; Prognostic factors; Réanimation; Severe community-acquired pneumonia; Épidémiologie