title: Surface-evoked laryngeal sensory action potential evaluation in neurogenic chronic cough.
abstract: OBJECTIVE
  Neurogenic chronic cough is currently a diagnosis of exclusion. We hypothesized that surface-evoked laryngeal sensory action potential (SELSAP) testing could be used to help establish a diagnosis of laryngeal sensory neuropathy as a cause of chronic cough, based on altered SELSAP waveform morphology.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Laryngeal electromyographic (EMG) data including SELSAP waveform testing from patients with chronic cough were directly compared with a control population without significant laryngeal symptoms, and statistical analysis of unilateral and bilateral neuropathy injury subgroups was performed.
  
  
  RESULTS
  Thirty patients with a chief complaint of chronic cough underwent laryngeal EMG testing since January 2000 with needle EMG and surface nerve conduction studies. SELSAP waveform analysis of unilateral and bilateral laryngeal neuropathy demonstrated significantly lowered median SELSAP peak amplitude compared with controls (P < 0.01).
  
  
  CONCLUSIONS
  Patients with suspected neurogenic chronic cough demonstrate statistically significant alterations in SELSAP waveform that can support a diagnosis of laryngeal sensory neuropathy.
authors.affiliation: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: jbock@mcw.edu.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Bock
authors.affiliation: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Koszewski
authors.affiliation: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Blumin
authors.affiliation: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Toohill
authors.affiliation: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington.
authors.forename: Albert L
authors.initials: AL
authors.lastname: Merati
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Prieto
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Neurology, Stanford University Medical Center, Palo Alto, California.
authors.forename: Safwan S
authors.initials: SS
authors.lastname: Jaradeh
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003371:Cough / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007818:Laryngeal Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D007830:Larynx / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: Chronic cough; Evoked potential; Laryngeal EMG; Neurogenic; Neuropathy; SELSAP