title: Clinical utility of antithrombotic prophylaxis in ART procedures: an Italian experience.
abstract: BACKGROUND
  The usefulness of antithrombotic prophylaxis in management of Assisted Reproductive Technologies (ART) is questionable.
  
  
  OBJECTIVE
  We prospectively examined the contribution of an antithrombotic prophylaxis in influencing clinical pregnancy and live-birth in an unselected cohort of women approaching ART.
  
  
  METHODS
  1107 women with fertility problems and a valid indication for ART were recruited. Baseline and follow-up information of obstetric outcomes and antithrombotic treatment were collected.
  
  
  CONCLUSIONS
  Median follow-up time was 34.5 months (range: 2-143). During the follow-up period, 595 (53.8%) women underwent ART (total 1234 cycles); 202 (33.9%) women achieved a pregnancy for a total of 255 clinical pregnancies. The concomitant use of LMWH and aspirin was significantly associated with a higher rate of clinical pregnancies (p: 0.003, OR: 4.9, 95% CI: 1.7-14.2). The pregnancy rate was also significantly increased by the use of LMWH alone (p: 0.005, OR: 2.6, 95% CI: 1.3-5.0). Carriership of inherited or acquired thrombophilia did not affect clinical outcomes of the ART. The efficacy of antithrombotic treatment was confirmed when the outcome " live-birth" was considered. Present data suggest a potential benefit of antithrombotic prophylaxis during ART in improving the number of live-births.
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Grandone
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Villani
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors.forename: Giovanni L
authors.initials: GL
authors.lastname: Tiscia
authors.affiliation: Department of Clinical Medicine, Insubria University, Varese, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Dentali
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Colaizzo
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors.forename: Filomena
authors.initials: F
authors.lastname: Cappucci
authors.affiliation: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Fischetti
authors.affiliation: Department of Clinical Medicine, Insubria University, Varese, Italy.
authors.forename: Walter
authors.initials: W
authors.lastname: Ageno
authors.affiliation: Medical Genetics, University of Foggia, Foggia, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Margaglione
mesh_terms: D015331:Cohort Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D050498:Live Birth / Q000453:epidemiology*; D016015:Logistic Models; D016017:Odds Ratio; D065129:Pre-Exposure Prophylaxis / Q000379:methods*; D011247:Pregnancy; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted
chemical_list: D005343:Fibrinolytic Agents