title: Comparative effects of plant oils on the cerebral hemorrhage in stroke-prone spontaneously hypertensive rats.
abstract: OBJECTIVE
  Since oils and fats can induce metabolic syndrome, leading to cardiovascular and cerebrovascular diseases, the present study was performed to find out whether the plant oils affect the cerebral hemorrhage in stroke-prone spontaneously hypertensive (SHR-SP) rats.
  
  
  METHODS
  From 47 days of age, male SHR-SP rats were given drinking water containing 1% NaCl to induce hypertension, and simultaneously fed semi-purified diets containing 10% perilla oil, canola oil, or shortening. The onset time of convulsion following cerebral hemorrhage was recorded, and the areas of hemorrhage and infarction were analyzed in the stroke brains.
  
  
  RESULTS
  In comparison with 58-day survival of SHR-SP rats during feeding NaCl alone, perilla oil extended the survival time to 68.5 days, whereas canola oil shortened it to 45.7 days. Feeding perilla oil greatly reduced the total volume of cerebral hemorrhage from 17.27% in the control group to 4.53%, while shortening increased the lesions to 21.23%. In a microscopic analysis, perilla oil also markedly decreased the hemorrhagic and infarction lesions to 1/10 of those in control rats, in contrast to an exacerbating effect of shortening. In blood analyses, perilla oil reduced blood total cholesterol and low-density lipoproteins which were increased in SHR-SP, but canola oil further increased them and markedly lowered platelet counts.
  
  
  CONCLUSIONS
  Perilla oil delayed and attenuated cerebral hemorrhage by improving hyperlipidemia in hypertensive stroke animals, in contrast to the aggravating potential of canola oil and shortening. It is suggested that perilla oil should be the first choice oil for improving metabolic syndrome in hypertensive persons at risk of hemorrhagic stroke.
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Cai
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Jang
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Jihyun
authors.initials: J
authors.lastname: Kim
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Kyungha
authors.initials: K
authors.lastname: Shin
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Kwang Sei
authors.initials: KS
authors.lastname: Kim
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Dongsun
authors.initials: D
authors.lastname: Park
authors.affiliation: b Misuba RTech Co., Ltd. , Asan , Korea.
authors.forename: Tae-Su
authors.initials: TS
authors.lastname: Kim
authors.affiliation: b Misuba RTech Co., Ltd. , Asan , Korea.
authors.forename: Sung-Pyo
authors.initials: SP
authors.lastname: Lee
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Byeongwoo
authors.initials: B
authors.lastname: Ahn
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Ehn-Kyoung
authors.initials: EK
authors.lastname: Choi
authors.affiliation: c Department of Food Science and Technology , Chungbuk National University , Cheongju , Korea.
authors.forename: Junsoo
authors.initials: J
authors.lastname: Lee
authors.affiliation: a College of Veterinary Medicine, Chungbuk National University , Cheongju , Korea.
authors.forename: Yun-Bae
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004041:Dietary Fats / Q000009:adverse effects; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D006973:Hypertension / Q000097:blood / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy / Q000209:etiology / Q000503:physiopathology; D009474:Neurons / Q000473:pathology; D010938:Plant Oils / Q000009:adverse effects / Q000627:therapeutic use*; D010976:Platelet Count; D011897:Random Allocation; D000074262:Rapeseed Oil; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017673:Sodium Chloride, Dietary / Q000009:adverse effects; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D016019:Survival Analysis; D013921:Thrombocytopenia / Q000209:etiology; D017962:alpha-Linolenic Acid / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D010938:Plant Oils; D000074262:Rapeseed Oil; D017673:Sodium Chloride, Dietary; D017962:alpha-Linolenic Acid; C058216:perilla seed oil; C029310:lard
keywords: Canola oil; Cerebral hemorrhage; Hyperlipidemia; Perilla oil; Shortening; Stroke-prone spontaneously hypertensive rat (SHR-SP)