title: The microtubular apparatus of cerebellar purkinje cell dendrites during postnatal development of the rat: The density and cold-stability of microtubules increase with age and are sensitive to thyroid hormone deficiency.
abstract: A quantitative ultrastructural study of microtubules in Purkinje cell dendrites of normal and hypothyroid developing rats was performed after fixation either at room or at low temperature (4°C). In normal animals, the density of microtubules and their fold-stability increased with age, more especially during the period of intense dendritic growth. Thyroid deficiency delayed the appearance of microtubules and still more the acquisition of their fold-stability. These effects might explain the defects in Purkinje cell dendritic growth and branching observed in hypothyroid animals.
authors.affiliation: Laboratoire de Physiologie comparée, UA 653 du CNRS, Neurobiologie du Développement et Endocrinologie, Université des Sciences et Techniques du Languedoc, 34060 Montpellier Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Faivre
authors.forename: C
authors.initials: C
authors.lastname: Legrand
authors.forename: A
authors.initials: A
authors.lastname: Rabié