title: Associations study of vitamin D receptor gene polymorphisms with diabetic microvascular complications: a meta-analysis.
abstract: BACKGROUND
  Emerging evidence from preclinical and clinical studies has shown that vitamin D plays an important role in the pathogenesis of diabetic microvascular complications (DMI). Several potentially functional polymorphisms (ApaI, BsmI, FokI and TaqI) of vitamin D receptor (VDR) gene have been implicated in DMI risk, but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between VDR polymorphisms and DMI risk.
  
  
  METHODS
  We searched all the publications about the associations mentioned as above from PubMed and ISI database updated in December 2013. Meta-analysis of the overall odds ratios (ORs) with 95% confidence intervals (CIs) was calculated with the fixed or random effect model.
  
  
  RESULTS
  Eight studies involving 2734 subjects were included. Allelic and genotypic comparisons between cases and controls were evaluated. Overall analysis suggests that no significant association was observed among the ApaI, BsmI, FokI and TaqI variants and DMI risk in diabetic patients (all P values >0.05). In the stratified analysis, significant association was observed with diabetic nephropathy (DN) for VDR gene FokI polymorphism under a dominant model (OR 1.35, 95% CI 1.05-1.74, P=0.02) in Caucasians.
  
  
  CONCLUSIONS
  This meta-analysis indicated that the FokI polymorphism in VDR gene might affect individual susceptibility to DN in Caucasians. Further investigations are needed to confirm our results.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Zhelong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: He
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: xfyu188@163.com.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yu
mesh_terms: D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D048909:Diabetes Complications / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D018167:Receptors, Calcitriol / Q000235:genetics*; D014652:Vascular Diseases / Q000209:etiology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific
keywords: Diabetic microvascular complications; Meta-analysis; Vitamin D receptor