title: [Löfgren syndrome: a study of 80 cases].
abstract: OBJECTIVE
  Löfgren's syndrome is characterized by hiliar adenopathies, erythema nodosum and arthritis. It is a benign variant of sarcoidosis, common in the Mediterranean area. To describe the clinical characteristics, treatment and outcome of a series of patients diagnosed with Löfgren's syndrome.
  
  
  METHODS
  Retrospective design (1984-2013).
  
  
  METHODS
  Two university hospitals with a reference population of 1,015,000 inhabitants.
  
  
  RESULTS
  Eighty patients were diagnosed: 29 men and 51 women (mean age 42.3 years). Forty eight patients (60%) presented with the classical triad: hiliar adenopathies, erythema nodosum and arthritis; 18 (22%) with hiliar adenopathy and arthritis; 13 (16%) hiliar adenopathies and erythema nodosum. All showed abnormalities in the chest study. According to the radiological pattern, patients were classified in stage i-ii. Biopsy was performed in 39 patients and was diagnostic in 28. Treatment was based on non-steroidal anti-inflammatory drugs (54 patients, 67%) and corticosteroids (33 patients, 41%). Fourteen patients (17%) suffered a recurrence of the disease.
  
  
  CONCLUSIONS
  Löfgren's syndrome is a benign form of sarcoidosis with a well defined clinical pattern. Biopsy is usually not required. Recurrence is scarce. The disease has a good prognosis.
authors.affiliation: Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: btejerasegura@gmail.com.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Tejera Segura
authors.affiliation: Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Holgado
authors.affiliation: Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mateo
authors.affiliation: Sección de Reumatología, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España; Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Pontevedra, España.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Pego-Reigosa
authors.affiliation: Sección de Reumatología, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España.
authors.forename: María
authors.initials: M
authors.lastname: Carnicero Iglesias
authors.affiliation: Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Olivé
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology*; D001706:Biopsy; D004893:Erythema Nodosum / Q000188:drug therapy / Q000209:etiology*; D005189:False Positive Reactions; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006785:Hospitals, University; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012008:Recurrence; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D014374:Tuberculin Test
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents
keywords: Eritema nodoso; Erythema nodosum; Löfgren's síndrome; Sarcoidosis; Síndrome de Löfgren