title: The relationship between the g.27450A>T genetic variant of OPG gene and osteoporosis in Chinese postmenopausal women.
abstract: The objective of this study is to evaluate the relationship between the g.27450A>T genetic variant of osteoprotegerin (OPG) gene and osteoporosis in Chinese postmenopausal women. A total of 886 subjects were enrolled in this study. The femoral neck hip, lumbar spine (L2-4), and total hip bone mineral density (BMD) were detected by dual-energy X-ray absorptiometry (DEXA). The genotyping of the g.27450A>T genetic variant of OPG gene was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Significant differences in the femoral neck hip, lumbar spine (L2-4), and total hip BMD among different genotypes were found, and the subjects with AA genotype were significantly higher than those of AT and TT genotypes (P<0.05). The allele-A could be a decreased risk factor for osteoporosis. Results from this study support that the g.27450A>T genetic variant of OPG gene has potential relationship with BMD and osteoporosis in Chinese postmenopausal women.
authors.affiliation: (a)Department of Orthopedics, Affiliated Putian Hospital of Southern Medical University, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Fujian Medical University Union Clinical Medical College, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guang Dong Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: (a)Department of Orthopedics, Affiliated Putian Hospital of Southern Medical University, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Fujian Medical University Union Clinical Medical College, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China. Electronic address: xuanhuang_chen@sina.com.
authors.forename: Xuanhuang
authors.initials: X
authors.lastname: Chen
authors.affiliation: (a)Department of Orthopedics, Affiliated Putian Hospital of Southern Medical University, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Fujian Medical University Union Clinical Medical College, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Wu
authors.affiliation: (a)Department of Orthopedics, Affiliated Putian Hospital of Southern Medical University, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Fujian Medical University Union Clinical Medical College, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China.
authors.forename: Changfu
authors.initials: C
authors.lastname: Wu
authors.affiliation: (a)Department of Orthopedics, Affiliated Putian Hospital of Southern Medical University, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Fujian Medical University Union Clinical Medical College, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China.
authors.forename: Hanhua
authors.initials: H
authors.lastname: Ca
authors.affiliation: (a)Department of Orthopedics, Affiliated Putian Hospital of Southern Medical University, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Fujian Medical University Union Clinical Medical College, Putian 351100, Fujian Province, People's Republic of China; Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, People's Republic of China.
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015519:Bone Density / Q000235:genetics; D005260:Female; D005272:Femur Neck / Q000473:pathology; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006615:Hip / Q000473:pathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D053244:Osteoprotegerin / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*
chemical_list: D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human
keywords: Bone mineral density; Genetic variants; Osteoporosis; Osteoprotegerin gene