title: Nitric oxide and histone acetylation-shaping craniofacial development.
abstract: Previous work linked nitric oxide (NO) signaling to histone deacetelyases (HDACs) in the control of tissue homeostasis and suggested that deregulation of this signaling contributes to human diseases. In the previous issue of Chemistry & Biology, Kong and colleagues showed that coordinated NO signaling and histone acetylation are required for proper cranial neural crest development and craniofacial morphogenesis and suggested that alterations of NO/acetylation network can contribute to the pathogenesis of craniofacial malformations.
authors.affiliation: Epigenetics & Regenerative Medicine, IRCCS Fondazione Santa Lucia, 00142 Rome, Italy.
authors.forename: Libera
authors.initials: L
authors.lastname: Berghella
authors.affiliation: Epigenetics & Regenerative Medicine, IRCCS Fondazione Santa Lucia, 00142 Rome, Italy; Development, Aging and Regeneration (DAR) Program, Sanford-Burnham Medical Research Institute, Sanford Children's Health Research Center, La Jolla, CA 92037, USA. Electronic address: lpuri@sanfordburnham.org.
authors.forename: Pier Lorenzo
authors.initials: PL
authors.lastname: Puri
mesh_terms: D000818:Animals; D006657:Histones / Q000378:metabolism*; D009024:Morphogenesis; D009432:Neural Crest / Q000196:embryology* / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism*
chemical_list: D006657:Histones; D009569:Nitric Oxide