title: A mathematical model of the immune and neuroendocrine systems mutual regulation under the technogenic chemical factors impact.
abstract: The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example.
authors.affiliation: Federal Budget Scientific Institution, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm 614000, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Zaitseva
authors.affiliation: Federal Budget Scientific Institution, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm 614000, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Kiryanov
authors.affiliation: Federal Budget Scientific Institution, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm 614000, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Lanin
authors.affiliation: Federal Budget Scientific Institution, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm 614000, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Chigvintsev
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000465:Algorithms; D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D001855:Bone Marrow Diseases / Q000473:pathology*; D002452:Cell Count; D019295:Computational Biology / Q000379:methods; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007107:Immune System / Q000502:physiology*; D007375:Interleukin-1 / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008962:Models, Theoretical; D009490:Neurosecretory Systems / Q000502:physiology*
chemical_list: D007375:Interleukin-1; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone