title: An easy route to synthetic analogues of radicamine B, codonopsine and codonopsinine from D-mannitol.
abstract: A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine and codonopsinine using appropriate Grignard reagents. The hence obtained molecules have been tested against various commercially available glycosidases and found to act as moderate to good inhibitors.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India. vankar@iitk.ac.in.
authors.forename: Suresh
authors.initials: S
authors.lastname: Dharuman
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Palanivel
authors.forename: Yashwant D
authors.initials: YD
authors.lastname: Vankar
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D008353:Mannitol / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D011759:Pyrrolidines; C415669:codonopsinine; C450645:radicamine B; D008353:Mannitol; D006026:Glycoside Hydrolases