title: Serum lipid profile in oral precancer and cancer: a diagnostic or prognostic marker?
abstract: BACKGROUND
  Changes in lipid profile have been associated with malignancy because of their key role in the maintenance the integrity of the cell membrane. This study evaluated the alterations in serum lipid profile in untreated patients of oral submucus fibrosis (OSMF), oral leukoplakia, and oral lichen planus and proven cases of oral cancer with respect to healthy controls.
  
  
  METHODS
  In this case control study, 20 clinically and histopathologically proven patients of oral precancer and oral cancer each were compared with 20 healthy controls. In these groups, serumlipids including: (i) Total cholesterol. (ii) Triglycerides (TGL). (iii) High density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL) were analyzed.
  
  
  RESULTS
  Decrease in plasma total cholesterol, triglycerides, HDL, LDL, VLDL in the subjects with the oral precancer and oral cancer as compared to the controls was statistically significant. There was also decrease in plasma levels of TGL and VLDL in oral cancer subjects as compared to precancer subjects. Thus, it was found that there is an inverse relationship between plasma lipid levels and patients.
  
  
  CONCLUSIONS
  Post operative morbidity was increasing along with more operating time and increase in the depth of mandibular third molar impaction. How to cite the article: Garg D, Sunil MK, Singh PP, Singla N, Rani SR, Kaur B. Serum lipid profile in oral precancer and cancer: a diagnostic or prognostic marker? J Int Oral Health 2014;6(2):33-9.
authors.affiliation: Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
authors.forename: Deepanshu
authors.initials: D
authors.lastname: Garg
authors.affiliation: Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Sunil
authors.affiliation: Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
authors.forename: Param Pal
authors.initials: PP
authors.lastname: Singh
authors.affiliation: Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
authors.forename: Neetu
authors.initials: N
authors.lastname: Singla
authors.affiliation: Department of Oral Medicine & Radiology, School of Dental Sciences, KIMSDU, Maharashtra, India.
authors.forename: S R Ashwini
authors.initials: SR
authors.lastname: Rani
authors.affiliation: Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
authors.forename: Beant
authors.initials: B
authors.lastname: Kaur
keywords: head cancer; leukoplakia; lichen planus; lipid profile; neck cancer; oral submucus fibrosis