title: Facile one-pot synthesis of folic acid-modified graphene to improve the performance of graphene-based sensing strategy.
abstract: A convenient and environment-friendly method is reported to synthesize the reduced graphene oxide (rGO) sheets in aqueous solution using folic acid (FA) as both a reducing and stabilizing agent, to improve the performance of graphene-based sensing strategy. The as-prepared FA-rGO sheets were characterized by transmission electron microscopy (TEM), UV-vis absorption spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, X-ray diffraction (XRD) and thermogravimetric analysis (TGA), which provided the clear identification of the removal of oxygen-containing functional groups from the graphene oxide (GO) to form FA-rGO sheets. Further, it was found that the obtained FA-rGO sheets exhibited better biocompatibility and could act as the more efficient energy acceptor in long range resonance energy transfer (LrRET) process than that of graphene. Additionally, the FA-rGO can also catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by H2O2, and compared with GO sheets, they exhibited the more prominent intrinsic peroxidase-like activity, thus providing the more sensitive approach for colorimetric detection of H2O2.
authors.affiliation: Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: zhanlei6@swu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: candyzy222@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address: xlzeng123@126.com.
authors.forename: Qiao Ling
authors.initials: QL
authors.lastname: Zeng
authors.affiliation: College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address: lzdzhy@swu.edu.cn.
authors.forename: Zhong De
authors.initials: ZD
authors.lastname: Liu
authors.affiliation: Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address: chengzhi@swu.edu.cn.
authors.forename: Cheng Zhi
authors.initials: CZ
authors.lastname: Huang
mesh_terms: D005492:Folic Acid / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis; D046529:Microscopy, Electron, Transmission; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D006108:Graphite; D005492:Folic Acid; D006861:Hydrogen Peroxide
keywords: Folic acid; Graphene-based sensing strategy; Reduced graphene oxide