title: Synthesis of some novel phosphorylated and thiophosphorylated benzimidazoles and benzothiazoles and their evaluation for larvicidal potential to Aedes albopictus and Culex quinquefasciatus.
abstract: Series of benzimidazole and benzothiazole linked phosphoramidates and phosphoramidothioates (5a-j) and benzimidazole linked phenylphosphoramidates and phenylphosphoramidothioates (10a-e) were synthesized. The title compounds were preliminary screened for mosquito larvicidal properties against Aedes albopictus and Culex quinquefasciatus at different concentration from 40 to 5 mg/L. Among the screened compounds three compounds revealed potential larvicidal effects with 100% mortality in the order of 10e>5j>5e. Compound 10e was found to be the most toxic compound to Ae. albopictus and Cx. quinquefasciatus. The LC50 of 10e against Ae. albopictus was found to be 6.42 and 5.25 mg/L at 24 and 48 h, respectively, whereas it was 7.01 and 3.88 mg/L, respectively in Cx. quinquefasciatus. Temephos was used as positive control.
authors.affiliation: Discovery Center, Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, MP, India.
authors.forename: Prabal
authors.initials: P
authors.lastname: Bandyopadhyay
authors.affiliation: Discovery Center, Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, MP, India.
authors.forename: Manisha
authors.initials: M
authors.lastname: Sathe
authors.affiliation: Vector Management Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, MP, India.
authors.forename: Sachin N
authors.initials: SN
authors.lastname: Tikar
authors.affiliation: Vector Management Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, MP, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Yadav
authors.affiliation: School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452001, MP, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Sharma
authors.affiliation: School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452001, MP, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Discovery Center, Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, MP, India. Electronic address: mpkaushik@rediffmail.com.
authors.forename: M P
authors.initials: MP
authors.lastname: Kaushik
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003465:Culex / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010766:Phosphorylation; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D052160:Benzothiazoles; D007306:Insecticides
keywords: Aedes albopictus; Benzimidazole/benzothiazole; Culex quinquefasciatus; Larvicidal activity; Phosphoramidate/phosphoramidothioate