title: Association of total adiposity and computed tomographic measures of regional adiposity with incident cancer risk: a prospective population-based study of older adults.
abstract: Obesity is associated with increased risk of many types of cancer. Less is known regarding associations between adipose depots and cancer risk. We aimed to explore relationships between adipose depots, risk of cancer, and obesity-related cancer (per NCI definition) in participants initially aged 70-79 years without prevalent cancer (1179 men, 1340 women), and followed for incident cancer for 13 years. Measures included body mass index (BMI), total adipose tissue from dual-energy X-ray absorptiometry, and computed tomography measures of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, thigh intermuscular adipose tissue, and thigh muscle attenuation (Hounsfield unit, HU), where low HU indicates fatty infiltration. Hazard ratios (HR) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards models adjusted for demographics, lifestyle variables, and medical conditions. During follow-up, 617 participants developed cancer of which 224 were obesity-related cancers. Total adipose tissue and VAT were positively associated with cancer risk among women (HR 1.14, 95% CI 1.01-1.30 per SD increase; HR 1.15, 95% CI 1.02-1.30 per SD increase). There were no associations with cancer risk among men. Total adipose tissue was positively associated with obesity-related cancer risk among women (HR 1.23, 95% CI 1.03-1.46 per SD increase). VAT was positively associated with obesity-related cancer risk among men (HR 1.30, 95% CI 1.06-1.60 per SD increase) and remained associated even with adjustment for BMI (HR 1.40, 95% CI 1.08-1.82 per SD increase). These findings provide insight into relationships between specific adipose depots and cancer risk and suggest differential relationships among men and women.
authors.affiliation: a Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, 7201 Wisconsin Ave, 3C-309, Bethesda, MD 20814, USA.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Murphy
authors.forename: Taylor F
authors.initials: TF
authors.lastname: Bureyko
authors.forename: Iva
authors.initials: I
authors.lastname: Miljkovic
authors.forename: Jane A
authors.initials: JA
authors.lastname: Cauley
authors.forename: Suzanne
authors.initials: S
authors.lastname: Satterfield
authors.forename: Trisha F
authors.initials: TF
authors.lastname: Hue
authors.forename: Heidi D
authors.initials: HD
authors.lastname: Klepin
authors.forename: Steven R
authors.initials: SR
authors.lastname: Cummings
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D014481:United States / Q000453:epidemiology
keywords: adipeux; adipose; aging; body fat; cancer incidence; cancer risk; gras corporel; incidence de cancer; obesity; obésité; poids; risque de cancer; vieillissement; weight