title: Liver dysfunction in alcoholics in Western Nepal.
abstract: To estimate liver function tests in patients with alcoholic fatty liver disease, alcoholic hepatitis and alcoholic cirrhosis and to compare the levels of enzymes between the groups. A hospital based case control study was carried out at Nepalgunj Medical College, Nepal from January 2013 to June 2013. A total of 150 alcoholic associated liver disorders patients aged between 20-70 years and 50 sex age matched normal healthy controls were taken to assess liver function tests (LFTs) by measuring Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Gamma glutamyltranspeptidase (GGT) & Albumin. The mean±SD of liver function tests (LFTs) of patients of alcoholic fatty liver disease is highest followed by alcoholic hepatitis patients. All the 3 groups of alcoholic associated liver disorders patients when compared to normal healthy control subjects showed statistically significant increase in the levels of AST (p<0.000), ALT (p<0.000), ALP (p<0.006), GGT (p<0.000), & Albumin (p<0.000). Liver function tests values for alcoholic associated liver disorders patients when compared to the healthy control subjects was significantly altered.
authors.affiliation: Miss Chhunthang Thanpari, Lecturer, Department of Biochemistry, Nepalgunj Medical College, Chisapani, Banke, Nepal.
authors.forename: C
authors.initials: C
authors.lastname: Thanpari
authors.forename: M K
authors.initials: MK
authors.lastname: Shrewastwa
authors.forename: R
authors.initials: R
authors.lastname: Takhelmayum
authors.forename: N K
authors.initials: NK
authors.lastname: Yadav
authors.forename: P
authors.initials: P
authors.lastname: Thapa
authors.forename: R K
authors.initials: RK
authors.lastname: Mittal
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis* / Q000453:epidemiology*; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D009390:Nepal; D012737:Sex Factors; D055815:Young Adult