title: Decreased placental thickness and impaired Doppler indices in idiopathic polyhydramnios: a prospective case-control study.
abstract: OBJECTIVE
  To evaluate placental thickness, Doppler velocimetry, biophysical profile and perinatal outcomes in pregnancies complicated by idiopathic polyhydramnios.
  
  
  METHODS
  This prospective case-control study was conducted on 139 pregnant women, of these 70 patients with idiopathic polyhydramnios comprised the study group and 60 pregnant women comprised the control group. Risk factors recorded were; age, parity, body mass index (BMI), gestational weeks, amniotic fluid index (AFI), biophysical profiles (BPP), placental thickness, middle cerebral artery pulsatility index (MCA PI), umbilical artery Doppler velocimetry (Umb A S/D) values and perinatal outcomes.
  
  
  RESULTS
  Sixty-nine of the cases had mild-moderate (AFI: 250-450 mm) polyhydramnios (%98.5) and one of the cases had severe polyhydramnios (>450 mm) in study group. There was no statistically significant difference between the groups in terms of age, parity, BMI, gestational weeks, fetal birth weights and BPP (p > 0.05). Placental thickness, MCA PI and UA S/D values showed statistically significant difference between the groups (p < 0.05). The fetuses with lower placental thickness had lower scores of biophysical profile. There were negative correlations between placental thickness and AFI (r = -0.265), umbilical artery S/D and placental thickness (r = -0.212), MCA PI and AFI (r = -171, p = 0.44). However there was a positive correlation between AFI and umbilical artery Doppler values (r = 0.450).
  
  
  CONCLUSIONS
  Idiopathic polyhydramnios is associated with decreased placental thickness, impaired uterine, umbilical and middle cerebral artery flow.
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Akgündüz
authors.forename: Selçuk
authors.initials: S
authors.lastname: Erkılınç
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.forename: Ali İrfan
authors.initials: Aİ
authors.lastname: Güzel
authors.forename: İrfan
authors.initials: İ
authors.lastname: Özer
authors.forename: Nuri
authors.initials: N
authors.lastname: Danışman
mesh_terms: D000328:Adult; D001724:Birth Weight; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D009929:Organ Size; D010920:Placenta / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D006831:Polyhydramnios / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D055815:Young Adult
keywords: Doppler velocimetry; middle cerebral artery; placental thickness; polyhydramnios; umbilical artery