title: The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome.
abstract: The amygdala is a key brain region with efferent and afferent neural connections that involve complex behaviors such as pain, reward, fear, and anxiety. This study evaluated resting state functional connectivity of the amygdala with cortical and subcortical regions in a group of chronic pain patients (pediatric complex regional pain syndrome) with age-sex matched control subjects before and after intensive physical-biobehavioral pain treatment. Our main findings include (1) enhanced functional connectivity from the amygdala to multiple cortical, subcortical, and cerebellar regions in patients compared with control subjects, with differences predominantly in the left amygdala in the pretreated condition (disease state); (2) dampened hyperconnectivity from the left amygdala to the motor cortex, parietal lobe, and cingulate cortex after intensive pain rehabilitation treatment within patients with nominal differences observed among healthy control subjects from time 1 to time 2 (treatment effects); (3) functional connectivity to several regions key to fear circuitry (prefrontal cortex, bilateral middle temporal lobe, bilateral cingulate, hippocampus) correlated with higher pain-related fear scores; and (4) decreases in pain-related fear associated with decreased connectivity between the amygdala and the motor and somatosensory cortex, cingulate, and frontal areas. Our data suggest that there are rapid changes in amygdala connectivity after an aggressive treatment program in children with chronic pain and intrinsic amygdala functional connectivity activity serving as a potential indicator of treatment response.
authors.affiliation: P.A.I.N. Group, Department of Anesthesia, Boston Children's Hospital and Center for Pain and the Brain, Boston, MA, USA Harvard Medical School, Boston, MA, USA Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Simons
authors.forename: M
authors.initials: M
authors.lastname: Pielech
authors.forename: N
authors.initials: N
authors.lastname: Erpelding
authors.forename: C
authors.initials: C
authors.lastname: Linnman
authors.forename: E
authors.initials: E
authors.lastname: Moulton
authors.forename: S
authors.initials: S
authors.lastname: Sava
authors.forename: A
authors.initials: A
authors.lastname: Lebel
authors.forename: P
authors.initials: P
authors.lastname: Serrano
authors.forename: N
authors.initials: N
authors.lastname: Sethna
authors.forename: C
authors.initials: C
authors.lastname: Berde
authors.forename: L
authors.initials: L
authors.lastname: Becerra
authors.forename: D
authors.initials: D
authors.lastname: Borsook
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000293:Adolescent; D000679:Amygdala / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D002648:Child; D020918:Complex Regional Pain Syndromes / Q000503:physiopathology* / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D011613:Psychotherapy
keywords: Brain; Children; Chronic pain; Fear; Neuropathic; Treatment response; fMRI