title: Epiphora in lung cancer patients receiving docetaxel: a case series.
abstract: BACKGROUND
  Docetaxel is a key antineoplastic drug for treatment of non-small cell lung cancer. Ocular adverse events of docetaxel include epiphora (excess tearing) and conjunctivitis. Epiphora has been reported to be associated with canalicular and nasolacrimal duct stenosis, but it is not necessarily caused by lacrimal duct obstruction.
  
  
  METHODS
  We encountered three Japanese non-small cell lung cancer patients who developed epiphora after the administration of docetaxel-based chemotherapy. One patient with lacrimal puncta stenosis showed improvement with probing and irrigation. The other two patients resolved following cessation of docetaxel or administration of artificial tears.
  
  
  CONCLUSIONS
  As epiphora can interfere with activities of daily life and negatively affect quality of life, it is important for thoracic oncologists to be aware of this adverse event.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ochi
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamane
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hasebe
authors.affiliation: Department of General Internal Medicine 4, Kawasaki Medical School, 2-1-80 Nakasange, Kita-ku, Okayama 700-8505, Japan. ntakigaw@med.kawasaki-m.ac.jp.
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000077143:Docetaxel; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel