title: Redox or death: checking on fetal myogenesis.
abstract: Reporting in this issue of Developmental Cell, L'honoré et al. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.
authors.affiliation: Laboratory of Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Institute of Translational Pharmacology, National Research Council of Italy, Via Fosso del Cavaliere 100, 00133 Rome, Italy. Electronic address: l.latella@hsantalucia.it.
authors.forename: Lucia
authors.initials: L
authors.lastname: Latella
authors.affiliation: Laboratory of Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Development Aging and Regeneration Program, Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: lpuri@sanfordburnham.org.
authors.forename: Pier Lorenzo
authors.initials: PL
authors.lastname: Puri
mesh_terms: D000818:Animals; D018398:Homeodomain Proteins / Q000235:genetics*; D051266:Nuclear Respiratory Factor 1 / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*; D000097577:Homeobox Protein PITX2
chemical_list: D018398:Homeodomain Proteins; D051266:Nuclear Respiratory Factor 1; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2; C495634:Nrf1 protein, mouse; C433629:homeobox protein PITX3