title: Steroid-sparing effects of etanercept in a patient with steroid-dependent adult-onset Still's disease.
abstract: We herein report the case of an 84-year-old man with steroid-dependent adult-onset Still's disease (AOSD) whose daily steroid dose was successfully tapered after etanercept treatment. The corticosteroids worked well initially, and the patient went into remission promptly; however, he suffered a relapse due to steroid tapering. Because treatment with cyclosporine and methotrexate was ineffective, reducing the steroid dose was difficult, and the corticosteroids induced myopathy and diabetes. However, steroid tapering was accomplished in combination with etanercept therapy, and the patient's steroid-induced side effects disappeared. Etanercept should therefore be considered as a steroid-sparing treatment option in patients with steroid-responsive, steroid-dependent AOSD.
authors.affiliation: Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kiyonaga
authors.forename: Keisuke
authors.initials: K
authors.lastname: Maeshima
authors.forename: Chiharu
authors.initials: C
authors.lastname: Imada
authors.forename: Miwa
authors.initials: M
authors.lastname: Haranaka
authors.forename: Koji
authors.initials: K
authors.lastname: Ishii
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibata
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects; D000369:Aged, 80 and over; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D016706:Still's Disease, Adult-Onset / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D016572:Cyclosporine; D011239:Prednisolone; D000068800:Etanercept; D008727:Methotrexate