title: Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy.
abstract: CONCLUSIONS
  Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of many sarcomas, PDT appears to be an organ- and function-sparing therapy, although it is more costly than other treatments.
  
  
  OBJECTIVE
  The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer.
  
  
  METHODS
  We studied the results of PDT when used as a primary treatment. We looked at survival, effect on tumor, side effects, voice, and costs.
  
  
  RESULTS
  The follow-up period was a median of 59 months. Nine of 10 patients were cured of their laryngeal cancer. PDT alone cured seven patients. All four of the sarcomas were cured using temoporfin. Two of three tumors that involved the anterior commissure were cured using only interstitial illumination with PDT. No serious side effects were noted. The patient's voices were improved after treatment in 5 of 10 cases, and none had a worsened voice.
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Örebro University Hospital.
authors.forename: Mathias P
authors.initials: MP
authors.lastname: von Beckerath
authors.forename: Johan A
authors.initials: JA
authors.lastname: Reizenstein
authors.forename: Attila L
authors.initials: AL
authors.lastname: Berner
authors.forename: Kent W O
authors.initials: KW
authors.lastname: Nordqvist
authors.forename: Fredrik J
authors.initials: FJ
authors.lastname: Landström
authors.forename: Axel Lennart
authors.initials: AL
authors.lastname: Löfgren
authors.forename: Claes G
authors.initials: CG
authors.lastname: Möller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013548:Sweden / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin
keywords: Cancer; PDT; larynx; porfimer sodium; sarcoma; squamous cell carcinoma; temoporfin; voice