title: A superfluorinated molecular probe for highly sensitive in vivo(19)F-MRI.
abstract: (19)F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo (19)F-MRI applications. The molecule, which bears 36 equivalent (19)F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
authors.affiliation: Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta", ‡Fondazione Centro Europeo Nanomedicina, and ∥Department of Electronics, Information, and Bioengineering, Politecnico di Milano , Milan, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Tirotta
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mastropietro
authors.forename: Chiara
authors.initials: C
authors.lastname: Cordiglieri
authors.forename: Lara
authors.initials: L
authors.lastname: Gazzera
authors.forename: Fulvio
authors.initials: F
authors.lastname: Baggi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Baselli
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bruzzone
authors.forename: Ileana
authors.initials: I
authors.lastname: Zucca
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cavallo
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Terraneo
authors.forename: Francesca
authors.initials: F
authors.lastname: Baldelli Bombelli
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Metrangolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Resnati
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D007279:Injections, Subcutaneous; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D011917:Rats, Inbred Lew; D014018:Tissue Distribution
chemical_list: D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated