title: Technical tips for collagenase injection treatment for Dupuytren contracture.
abstract: We describe technical tips for injecting collagenase into Dupuytren cords based on experience acquired during the prerelease Food and Drug Administration clinical trials and with subsequent clinical practice. These tips include techniques for extracting the reconstituted enzyme efficiently from the vial, injecting the cord(s) with increased safety to the tendons, and anesthetizing the hand before manipulation. The tips are intended to supplement but by no means replace the manufacturer's prescribing information and training video.
authors.affiliation: Department of Orthopedic Surgery, University of California at Los Angeles; Department of Plastic Surgery, Stanford University, Stanford, CA. Electronic address: rmeals@ucla.edu.
authors.forename: Roy A
authors.initials: RA
authors.lastname: Meals
authors.affiliation: Department of Orthopedic Surgery, University of California at Los Angeles; Department of Plastic Surgery, Stanford University, Stanford, CA.
authors.forename: Vincent R
authors.initials: VR
authors.lastname: Hentz
mesh_terms: D047009:Hathewaya histolytica / Q000201:enzymology*; D004387:Dupuytren Contracture / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D003012:Microbial Collagenase / Q000008:administration & dosage*; D016896:Treatment Outcome; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D003012:Microbial Collagenase
keywords: Dupuytren; collagenase; injection; technique