title: Zebrafish and conditioned place preference: a translational model of drug reward.
abstract: Addiction and substance abuse are found ubiquitously throughout human society. In the United States, these disorders are responsible for amassing hundreds of billions of dollars in annual costs associated with healthcare, crime and lost productivity. Efficacious treatments remain few in number, the development of which will be facilitated by comprehension of environmental, genetic, pharmacological and neurobiological mechanisms implicated in the pathogenesis of addiction. Animal models such as the zebrafish (Danio rerio) have gained momentum within various domains of translational research, and as a model of complex brain disorders (e.g., drug abuse). Behavioral quantification within the conditioned place preference (CPP) paradigm serves as a measure of the rewarding qualities of a given substance. If the animal develops an increase in preference for the drug paired environment, it is inferred that the drug has positive-reinforcing properties. This paper discusses the utility of the zebrafish model in conjunction with the CPP paradigm and reports CPP behavior following acute exposure to 0.0%, 0.25%, 0.50%, and 1.00% alcohol, and 0 mg/L, 50 mg/L, 100 mg/L and 150 mg/L caffeine.
authors.affiliation: Department of Psychology, The University of Southern Mississippi, 118 College Drive, Box 5025, Hattiesburg, MS 39406, USA. Electronic address: Adam.d.collier@eagles.usm.edu.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Collier
authors.affiliation: Department of Psychology, The University of Southern Mississippi, 118 College Drive, Box 5025, Hattiesburg, MS 39406, USA. Electronic address: Kanza.khan@eagles.usm.edu.
authors.forename: Kanza M
authors.initials: KM
authors.lastname: Khan
authors.affiliation: Department of Psychology, The University of Southern Mississippi, 118 College Drive, Box 5025, Hattiesburg, MS 39406, USA. Electronic address: Erika.caramillo@eagles.usm.edu.
authors.forename: Erika M
authors.initials: EM
authors.lastname: Caramillo
authors.affiliation: Department of Educational Studies and Research, The University of Southern Mississippi, 118 College Drive, Box 5093, Hattiesburg, MS 39406, USA. Electronic address: Richard.mohn@usm.edu.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Mohn
authors.affiliation: Department of Psychology, The University of Southern Mississippi, 118 College Drive, Box 5025, Hattiesburg, MS 39406, USA. Electronic address: David.Echevarria@usm.edu.
authors.forename: David J
authors.initials: DJ
authors.lastname: Echevarria
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002110:Caffeine / Q000008:administration & dosage; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D003214:Conditioning, Classical / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage; D012201:Reward; D013028:Space Perception / Q000187:drug effects*; D013037:Spatial Behavior / Q000187:drug effects; D019966:Substance-Related Disorders; D015027:Zebrafish
chemical_list: D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D002110:Caffeine; D000431:Ethanol
keywords: Addiction; Alcohol; Caffeine; Conditioned place preference; Zebrafish