title: A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications.
abstract: In this paper, the authors' review the applicability of the open-source GATE Monte Carlo simulation platform based on the GEANT4 toolkit for radiation therapy and dosimetry applications. The many applications of GATE for state-of-the-art radiotherapy simulations are described including external beam radiotherapy, brachytherapy, intraoperative radiotherapy, hadrontherapy, molecular radiotherapy, and in vivo dose monitoring. Investigations that have been performed using GEANT4 only are also mentioned to illustrate the potential of GATE. The very practical feature of GATE making it easy to model both a treatment and an imaging acquisition within the same framework is emphasized. The computational times associated with several applications are provided to illustrate the practical feasibility of the simulations using current computing facilities.
authors.affiliation: Université de Lyon, CREATIS; CNRS UMR5220; Inserm U1044; INSA-Lyon; Université Lyon 1; Centre Léon Bérard, France.
authors.forename: David
authors.initials: D
authors.lastname: Sarrut
authors.affiliation: Inserm, UMR1037 CRCT, F-31000 Toulouse, France and Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000 Toulouse, France.
authors.forename: Manuel
authors.initials: M
authors.lastname: Bardiès
authors.affiliation: INSERM, UMR 1101, LaTIM, CHU Morvan, 29609 Brest, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Boussion
authors.affiliation: Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, Centre Léon Bérard, 69008 Lyon, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Freud
authors.affiliation: CEA/DSV/I2BM/SHFJ, Orsay 91401, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Jan
authors.affiliation: Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, Centre Léon Bérard, 69008 Lyon, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Létang
authors.affiliation: Department of Medical Instruments Technology, Technological Educational Institute of Athens, Athens 12210, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Loudos
authors.affiliation: UMR 6533 CNRS/IN2P3, Université Blaise Pascal, 63171 Aubière, France.
authors.forename: Lydia
authors.initials: L
authors.lastname: Maigne
authors.affiliation: Inserm, UMR1037 CRCT, F-31000 Toulouse, France and Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000 Toulouse, France.
authors.forename: Sara
authors.initials: S
authors.lastname: Marcatili
authors.affiliation: Inserm, UMR1037 CRCT, F-31000 Toulouse, France and Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000 Toulouse, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Mauxion
authors.affiliation: Department of Biomedical Engineering, Technological Educational Institute of Athens, 12210, Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Papadimitroulas
authors.affiliation: UMR 6533 CNRS/IN2P3, Université Blaise Pascal, 63171 Aubière, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Perrot
authors.affiliation: Institut für Neurowissenschaften und Medizin, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany and Fachbereich für Mathematik und Naturwissenschaften, Bergische Universität Wuppertal, 42097 Wuppertal, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Pietrzyk
authors.affiliation: IMNC, UMR 8165 CNRS, Universités Paris 7 et Paris 11, Orsay 91406, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Robert
authors.affiliation: Delft University of Technology, Faculty of Applied Sciences, Radiation Science and Technology Department, Delft Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Schaart
authors.affiliation: INSERM U1101, LaTIM, CHU Morvan, 29609 Brest, France.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Visvikis
authors.affiliation: IMNC, UMR 8165 CNRS, Universités Paris 7 et Paris 11, 91406 Orsay, France and CEA/DSV/I2BM/SHFJ, 91400 Orsay, France.
authors.forename: Irène
authors.initials: I
authors.lastname: Buvat
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D009010:Monte Carlo Method; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy / Q000379:methods*