title: [An adult patient with 49, XXXXY syndrome: further clinical and biological delineation].
abstract: 49, XXXXY syndrome is a rare sex chromosome aneuploidy occurring in 1:80 000-1:100 000 male births. Data on this aneuploidy in adulthood are limited, with most of the literature data based on paediatric patients. We report a new male patient whose 49, XXXXY diagnosis was formally made at the age of 54 years. So far, no medical follow-up was performed specifically for his condition. This man presented with facial features (epicanthus, hypertelorism, up-slanting palpebral fissures), microorchidism and features of chronic hypoandrogenism with muscular weakness, sparse body hair, dry skin with abnormal healing of skin wounds. Endocrine evaluation confirmed a hypergonadotropic hypogonadism. He had moderate intellectual deficiency with more affected verbal skills. A recent deep vein thrombosis was diagnosed in his left leg. Unusually, in addition to moderate deafness, he developed progressively a severe vision impairment leading to blindness. There have been very few reports of adult individuals with 49, XXXXY syndrome and this kind of report may contribute to improved management of prospective medical healthcare associated with this condition in older individuals.
authors.affiliation: Laboratoire de génétique, Inserm U-954, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Collet
authors.affiliation: Service d'endocrinologie et gynécologie médicale, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Chatelin
authors.affiliation: Service d'endocrinologie et gynécologie médicale, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Mikaël
authors.initials: M
authors.lastname: Agopiantz
authors.affiliation: Laboratoire de génétique, Inserm U-954, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Mylène
authors.initials: M
authors.lastname: Valduga
authors.affiliation: Laboratoire de génétique, Inserm U-954, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Bonnet
authors.affiliation: Laboratoire de génétique, Inserm U-954, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Lila
authors.initials: L
authors.lastname: Allou
authors.affiliation: Laboratoire de génétique, Inserm U-954, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Lambert
authors.affiliation: Service de neurologie, Université de Lorraine, Centre Hospitalier Universitaire de Nancy, Nancy, France.
authors.forename: Razvan Nicolaie
authors.initials: RN
authors.lastname: Gospodaru
authors.affiliation: Service d'endocrinologie et gynécologie médicale, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Weryha
authors.affiliation: Laboratoire de génétique, Inserm U-954, Université de Lorraine, Centre Hospitalier de Nancy, Vandoeuvre les Nancy, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Jonveaux
mesh_terms: D000782:Aneuploidy; D001766:Blindness / Q000175:diagnosis; D003638:Deafness / Q000175:diagnosis; D005143:Eyelids / Q000002:abnormalities; D019066:Facies; D006801:Humans; D006972:Hypertelorism / Q000175:diagnosis; D007006:Hypogonadism / Q000175:diagnosis; D008607:Intellectual Disability / Q000175:diagnosis; D007713:Klinefelter Syndrome / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged
keywords: 49; XXXY syndrome; aneuploidy