title: Serotonin as a stimulator of hippocampal cell differentiation in tissue culture.
abstract: The effects of serotonin (5-HT) on morphofunctional development of hippocampal cultures derived from newborn rats were studied. It was established that systematic addition of 5-HT to nutrient medium during cultivation stimulates neuropil development, axon myelination and synaptogenesis. Electrophysiological studies of hippocampal cells in 5-HT treated cultures showed earlier exhibition of spontaneous activity and an increased number of spontaneously firing neurons and prevalence of periodic (bursting) type of discharges. These results indicate that 5-HT stimulates the differentiation of hippocampal cells in tissue culture.
authors.affiliation: Laboratory of Brain Neurotransmitter Systems, Institute of Biophysics of the USSR Academy of Sciences, PushchinoUSSR.
authors.forename: H A
authors.initials: HA
authors.lastname: Gromova
authors.affiliation: Laboratory of Brain Neurotransmitter Systems, Institute of Biophysics of the USSR Academy of Sciences, PushchinoUSSR.
authors.forename: A R
authors.initials: AR
authors.lastname: Chubakov
authors.affiliation: Laboratory of Normal and Pathological Morphology of Nervous System, Institute of Experimental Medicine of the USSR Academy of Medical Sciences, Leningrad, USSR.
authors.forename: E I
authors.initials: EI
authors.lastname: Chumasov
authors.affiliation: Laboratory of Normal and Pathological Morphology of Nervous System, Institute of Experimental Medicine of the USSR Academy of Medical Sciences, Leningrad, USSR.
authors.forename: H V
authors.initials: HV
authors.lastname: Konovalov