title: [Novel class III antiarrhythmic agent niferidile: review of experimental and clinical studies].
abstract: This article reviews experimental and clinical studies of a novel antiarrhythmic agent niferidile. Niferidile, a class III antiarrhythmic agent, blocks potassium outward currents, prolongs repolarization and refractory periods predominantly in atria than in ventricles. Intravenous Niferidile was efficient for interruption of AV-nodal and orthodromic re-entrant tachycardias with rates of 75% to 80%. Niferidile had a conversion rate of up to 87.3% in persistent atrial fibrillation and up to 100% in persistent atrial flutter. Proarrhythmic action of niferidil administration manifested as nonsustained torsade de pointes and monomorphic ventricular tachycardia in 1.2 and 3.7% of cases, respectively. Niferidile can be used for pharmacological cardioversion of persistent atrial fibrillation and flutter as an alternative to electrical cardioversion.
authors.forename: E B
authors.initials: EB
authors.lastname: Maĭkov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Iuricheva
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Mironov
authors.forename: S F
authors.initials: SF
authors.lastname: Sokolov
authors.forename: S P
authors.initials: SP
authors.lastname: Golitsyn
authors.forename: L V
authors.initials: LV
authors.lastname: Rozenshtraukh
authors.forename: E I
authors.initials: EI
authors.lastname: Chazov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000187:drug effects; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D026902:Potassium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D010880:Piperidines; D026902:Potassium Channel Blockers; C578899:niferidil