title: Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease.
abstract: BACKGROUND
  Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are associated with CAD in type 2 diabetic subjects. The present study investigated the relationship between circulating C1q-APN levels and the number of angiographic coronary artery vessel in male subjects.
  
  
  METHODS
  The study subjects were 53 male Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), high-molecular weight adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays.
  
  
  RESULTS
  Serum C1q-APN/Total-APN ratio significantly increased in subjects with single and multi-vessel coronary diseases (p = 0.029 for trend, the Kruskal-Wallis test). However, serum Total-APN, HMW-APN, C1q-APN and C1q levels did not correlate with number of diseased coronary vessels.
  
  
  CONCLUSIONS
  Serum C1q-APN/Total-APN ratio progressively increases in men with single and multi-vessel coronary disease.
  
  
  BACKGROUND
  UMIN000002997.
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan ; Kishida Clinic, Toyonaka, Osaka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kishida
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: Department of Cardiology, Kenporen Osaka Central Hospital, Osaka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yanagi
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan ; Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
keywords: Adiponectin; Angiographic coronary vessel; C1q; C1q-binding adiponectin; Coronary artery disease