title: Synthesis of fluorinated heteroaromatics through formal substitution of a nitro group by fluorine under transition-metal-free conditions.
abstract: An efficient and transition-metal-free approach was developed to access a series of fluorinated heteroaromatics in moderate to excellent yields. This one-pot procedure features a triple-relay transformation of rapid dearomatization, fluorination, and rearomatization processes, which represents a conceptually novel strategy of combining partial hydrogenation and electrophilic fluorination.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (P. R. China), Fax: (+86) 411-84379220; Department of Chemistry, Dalian University of Technology, Dalian 116012 (P. R. China).
authors.forename: Ran-Ning
authors.initials: RN
authors.lastname: Guo
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Cai
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Zhang-Pei
authors.initials: ZP
authors.lastname: Chen
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D005461:Fluorine / Q000737:chemistry*; D054879:Halogenation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006865:Hydrogenation; D028561:Transition Elements / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D028561:Transition Elements; D005461:Fluorine
keywords: fluorination; heterocycles; hydrogenation; nitro compounds; rearomatization