title: [Effects of Porphyromonas gingivalis infection on intercellular adhesion molecule-1 expression in rat vascular smooth muscle cells].
abstract: OBJECTIVE
  To observe the effects of Porphyromonas gingivalis (P. gingivalis) ATCC 33277 infection on expression of intercellular adhesion molecule-1 (ICAM-1) in rat vascular smooth muscle cells(VSMC).
  
  
  METHODS
  An infection model of rat VSMC invaded by P. gingivalis was established in vitro. The mRNA of ICAM-1 was measured through reverse transcription-polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  Compared with the control group, an apparent and statistically significant increase in expression of ICAM-1 mRNA was observed after 8, 16, and 24 h in P. gingivals-infected rat VSMC (P<0.05). The expression reached its peak at 16 h. Statistically significant differences were observed in the 8 h group and in the other two experimental groups (P<0.05).
  
  
  CONCLUSIONS
  Infection of P. gingivals in rat VSMC can cause increased expression of ICAM-1, which may have an important function in the progression of atherosclerosis.
authors.forename: Jiayin
authors.initials: J
authors.lastname: Dai
authors.forename: Jiang
authors.initials: J
authors.lastname: Lin
authors.forename: Liangjia
authors.initials: L
authors.lastname: Bi
authors.forename: Lining
authors.initials: L
authors.lastname: Jiao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D018799:Intercellular Adhesion Molecule-1; D009131:Muscle, Smooth, Vascular; D032389:Myocytes, Smooth Muscle; D016966:Porphyromonas gingivalis; D012333:RNA, Messenger; D051381:Rats
chemical_list: D012333:RNA, Messenger; D018799:Intercellular Adhesion Molecule-1