title: Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study.
abstract: The objective of the present longitudinal study was to clarify whether osteophytosis and joint space narrowing predict quality of life (QOL) decline using a longitudinal population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. The present study analyzed 1,525 participants who completed the radiographic examination at baseline and questionnaires regarding QOL at a 3-year follow-up (546 men and 979 women; mean age, 67.0 ± 11.0 years). This study examined the associations of osteophyte area (OPA) and minimum joint space width (mJSW) in the medial compartment of the knee at baseline with pain and physical functional disability measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). OPA and mJSW in the medial compartment of the knee were measured using a knee osteoarthritis (OA) computer-aided diagnosis system. Overall, OPA independently predicted physical functional disability after 3 years of follow-up. When analyzed in men and women separately, OPA, rather than mJSW, was an independent predictor for pain and physical functional disability after 3 years of follow-up in men. OPA, rather than mJSW, also predicted worsening of pain in men during the 3-year follow-up, whereas in women, mJSW, rather than OPA, predicted worsening of pain. In conclusion, the present longitudinal study using a large-scale population from the ROAD study found gender differences in the association of osteophytosis and joint space narrowing with pain and physical functional disability.
authors.affiliation: Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan, murakis-ort@h.u-tokyo.ac.jp.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
authors.forename: Keiji
authors.initials: K
authors.lastname: Nagata
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Ishimoto
authors.forename: Munehito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tokimura
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007564:Japan; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000453:epidemiology*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D011788:Quality of Life; D012720:Severity of Illness Index; D012727:Sex Characteristics; D011795:Surveys and Questionnaires; D055815:Young Adult