title: The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance.
abstract: Objective. Substances such as inositol and N-acetylcysteine (NAC) have been recently shown to be effective in treatment of PCOS patients. The aim of this prospective trial is to evaluate the efficacy of NAC + Inositol + folic acid on ovulation rate and menstrual regularity in PCOS patients with and without insulin resistance. Methods. Among the 91 PCOS patients treated with NAC + Inositol + folic, insulin resistance was present in 44 subjects (A) and absent in 47 (B). The primary endpoint was the ovulation rate/year, determined by menstrual diary, serum progesterone performed between 21° and 24° days, ultrasound findings of growth follicular or luteal cysts, and luteal ratio. HOMA-index assessment after 6 and 12 months of treatment was evaluated as secondary endpoint. Results. In both groups there was a significant increase in ovulation rate and no significant differences were found in the primary outcome between two groups. In group A, a significant reduction of HOMA-index was observed. Conclusions. The association NAC + Inositol + folic, regardless of insulin-resistance state, seems to improve ovarian function in PCOS patients. Therefore, inositol and NAC may have additional noninsulin-related mechanisms of action that allow achieving benefits also in those patients with negative HOMA-index.
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Angela
authors.identifier: 0000-0001-6626-0970
authors.initials: A
authors.lastname: Sacchinelli
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Roberta
authors.identifier: 0000-0003-1359-770X
authors.initials: R
authors.lastname: Venturella
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Lico
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Di Cello
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Antonella
authors.identifier: 0000-0002-0136-7213
authors.initials: A
authors.lastname: Lucia
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Rania
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cirillo
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
authors.forename: Fulvio
authors.identifier: 0000-0003-3726-7561
authors.initials: F
authors.lastname: Zullo