title: Current insecticide susceptibility status of Malaysian Anopheles maculatus Theobald to malathion, permethrin, DDT and deltamethrin.
abstract: Chemical insecticides are still considered as important control agents for malaria vector control. However, prolonged use of these chemicals may select mosquito vectors for resistance. In this study, susceptibility status of adult Anopheles maculatus collected from 9 localities in peninsular Malaysia, viz., Jeli, Temerloh, Pos Banun, Senderut, Jeram Kedah, Segamat, Kota Tinggi, Kluang and Pos Lenjang were determined using the standard WHO bioassay method in which the adult mosquitoes were exposed to standard insecticide impregnated papers malathion, permethrin, DDT and deltamethrin--at pre-determined diagnostic dosage. Deltamethrin was most effective insecticide among the four insecticides tested, with the LT50 of 29.53 min, compared to malathion (31.67 min), DDT (47.76 min) and permethrin (48.01 min). The effect of all insecticides on the laboratory strain was greater (with all insecticides demonstrated LT50 < 1 hour) than the field strains (deltamethrin 32.7, malathion 53.0, permethrin 62.0, DDT 67.4 min). An. maculatus exhibited low degree of resistance to all test insecticides, indicating that these chemical insecticides are still effective in the control of malaria vector.
authors.affiliation: Medical Entomology Unit, IDRC, Institute for Medical Research, 50588 Kuala Lumpur.
authors.forename: A
authors.initials: A
authors.lastname: Rohani
authors.affiliation: Medical Entomology Unit, IDRC, Institute for Medical Research, 50588 Kuala Lumpur.
authors.forename: I
authors.initials: I
authors.lastname: Aziz
authors.affiliation: Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: M N
authors.initials: MN
authors.lastname: Zurainee
authors.affiliation: Medical Entomology Unit, IDRC, Institute for Medical Research, 50588 Kuala Lumpur.
authors.forename: S H
authors.initials: SH
authors.lastname: Rohana
authors.affiliation: Medical Entomology Unit, IDRC, Institute for Medical Research, 50588 Kuala Lumpur.
authors.forename: I
authors.initials: I
authors.lastname: Zamree
authors.affiliation: Medical Entomology Unit, IDRC, Institute for Medical Research, 50588 Kuala Lumpur.
authors.forename: H L
authors.initials: HL
authors.lastname: Lee
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D003634:DDT / Q000494:pharmacology; D005843:Geography; D006801:Humans; D007303:Insect Vectors / Q000187:drug effects*; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D008288:Malaria / Q000517:prevention & control*; D008294:Malathion / Q000494:pharmacology; D008297:Male; D009032:Mosquito Control / Q000379:methods*; D009570:Nitriles / Q000494:pharmacology; D026023:Permethrin / Q000494:pharmacology; D011722:Pyrethrins / Q000494:pharmacology
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D026023:Permethrin; D003634:DDT; D008294:Malathion