title: The contribution of HLA molecules to Dupuytren's contracture in a Southeast Brazilian population.
abstract: OBJECTIVE
  The aim of the present study was to investigate the HLA phenotype in Dupuytren's contracture (DC) patients in order to verify the correlation of these alleles with risk factors for development of DC in the Brazilian population.
  
  
  METHODS
  This was a case-controlled study of 25 DC patients and 443 healthy individuals with no history of HLA-associated diseases. HLA class I and class II typing was performed using the polymerase chain reaction sequence-specific primer method.
  
  
  RESULTS
  The HLAB*18 phenotype was observed in 32% of the patients and 10.5% of controls. However, P values did not remain significant after correction.
  
  
  CONCLUSIONS
  Although we observed an increased tendency of DC patients to possess the HLA-B*18 allele, the results were not statistically significant after correction. This allele was higher in patients of Italian and/or Spanish ethnicity, localities with frequencies higher than 18.0% and 14.0% respectively. Further investigation with a larger cohort of DC patients is required to confirm the potential role of HLA in this disease.
authors.affiliation: Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: Sônia Maria Ruiz Silva
authors.initials: SM
authors.lastname: Usó
authors.affiliation: Faculdade de Medicina, Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Ana Claudia Santos
authors.initials: AC
authors.lastname: Sanson
authors.affiliation: Faculdade de Medicina, Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Fabiana de Souza
authors.initials: Fde S
authors.lastname: Covolo-Santana
authors.affiliation: Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: Elaine Valim Camarinha
authors.initials: EV
authors.lastname: Marcos
authors.affiliation: Departamento de Reabilitação, Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Tatiani
authors.initials: T
authors.lastname: Marques
authors.affiliation: Departamento de Reabilitação, Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Milton
authors.initials: M
authors.lastname: Cury Filho
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Somei
authors.initials: S
authors.lastname: Ura
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D016022:Case-Control Studies; D004387:Dupuytren Contracture / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006680:HLA Antigens