title: Evaluation of immune parameters in chronic migraine with medication overuse.
abstract: It has been postulated that chronic pain and chronic migraine in particular, can be connected to immunologic disturbances. Moreover the psychiatric comorbidity is often responsible of migraine chronification, but also of developing of particular immune function alterations. The role of the immune system in migraine precipitation is still under debate also if speculations about the evidence of infections in migraine patients has been performed, but not always corroborated by clinical and scientific explanations. In this report we present an evaluation of specific immune parameters in patients suffering from different forms of migraine respect to controls in order to determine possible alterations in immune function: speculations about the evidenced abnormalities are attempted.
authors.affiliation: Headache Center, C. Besta Neurological Institute and Foundation, Via Celoria, 11, 20133, Milan, Italy, grazzi.l@istituto-besta.it.
authors.forename: L
authors.initials: L
authors.lastname: Grazzi
authors.forename: E
authors.initials: E
authors.lastname: Corsini
authors.forename: E
authors.initials: E
authors.lastname: Ciusani
authors.forename: S
authors.initials: S
authors.lastname: Usai
authors.forename: C
authors.initials: C
authors.lastname: Vasco
authors.forename: G
authors.initials: G
authors.lastname: Bussone
mesh_terms: D000328:Adult; D018941:Antigens, CD19 / Q000097:blood; D017252:CD3 Complex / Q000097:blood; D018791:CD4 Lymphocyte Count; D016827:CD8 Antigens / Q000097:blood; D002908:Chronic Disease; D005260:Female; D051271:Headache Disorders, Secondary / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008881:Migraine Disorders / Q000276:immunology*
chemical_list: D018941:Antigens, CD19; D017252:CD3 Complex; D016827:CD8 Antigens