title: Detoxification of Echis ocellatus venom-induced toxicity by Annona senegalensis Pers.
abstract: Different fractions (I-V) of the methanolic leaf extracts of Annona senegalensis were assessed for their anti-snake venom activities. Fractions III neutralized lethal toxicity induced by Echis ocellatus venom and manifested the same potency as the crude extracts against the venom. The anti-snake venom activity of fraction III was clearly shown by the complete abrogation of venom-induced haemorrhage and the 75% record of surviving mice which were injected with a pre-incubate of venom and extract in the ratio 1:30 w/w after a 24 h. Also, fraction III exhibited a weak inhibitory effect on fibrinogen clotting activity of this venom. The key phytochemicals mediating the activity of this fraction are flavonoids and tannins. The detoxification of this venom by fraction III and the possible mode of action in the pathology of snake envenoming is discussed in this report.
authors.forename: Amlabu
authors.initials: A
authors.lastname: Emmanuel
authors.forename: Ajagun
authors.initials: A
authors.lastname: Ebinbin
authors.forename: Wandayi
authors.initials: W
authors.lastname: Amlabu
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry*; D000997:Antivenins / Q000494:pharmacology / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D012909:Snake Bites / Q000188:drug therapy*; D013634:Tannins / Q000494:pharmacology / Q000627:therapeutic use; D014688:Venoms / Q000633:toxicity*; D017819:Viperidae
chemical_list: D000997:Antivenins; D005419:Flavonoids; D010936:Plant Extracts; D013634:Tannins; D014688:Venoms; D005340:Fibrinogen