title: Plasmid-mediated AmpC β-lactamase (CMY-2) gene in Salmonella typhimurium isolated from diarrheic pigs in South Korea.
abstract: BACKGROUND
  Salmonella resistant to third-generation cephalosporin has been isolated from an increasing number of animals worldwide. The purpose of this study was to examine ESBL (extended-spectrum β-lactamases)-producing and PABL (plasmid-mediated AmpC β-lactamases)-producing Salmonella isolates from pigs in South Korea.
  
  
  RESULTS
  Salmonella Typhimurium KVCC-BA1300259 was resistant to ampicillin, amoxicillin/clavulanic acid, cephalothin, chloramphenicol, florfenicol, cefoxithin, gentamicin, nalidixic acid, trimethoprim/sulfamethoxazole, tetracycline, and ceftiofur. The results of a double-disk synergy test and PCR confirmed that the isolate produced CMY-2 (PABL). Analysis of plasmid incompatibility (Inc) groups revealed the presence of IncA/C and IncFIB, indicating antimicrobial resistance. This study is the first to identify S. Typhimurium isolates harboring CMY-2 in pigs in South Korea.
  
  
  CONCLUSIONS
  The presence of CMY-2 in pigs poses a significant threat of possible horizontal spread between animals and humans.
authors.forename: Ki-Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Seong-In
authors.initials: SI
authors.lastname: Lim
authors.forename: Hwan-Won
authors.initials: HW
authors.lastname: Choi
authors.forename: Suk-Kyung
authors.initials: SK
authors.lastname: Lim
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Song
authors.affiliation: Animal and Plant Quarantine Agency, Anyang, Republic of Korea. andj67@korea.kr.
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: An
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary*; D010957:Plasmids; D056910:Republic of Korea; D012486:Salmonella typhimurium / Q000302:isolation & purification*; D013552:Swine; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C103022:beta-lactamase CMY-2; D001618:beta-Lactamases