title: Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives.
abstract: Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Mori
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Asako
authors.initials: A
authors.lastname: Kato
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Komenoi
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Haruaki
authors.initials: H
authors.lastname: Kurasaki
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Touru
authors.initials: T
authors.lastname: Iijima
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawagoshi
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Y B
authors.initials: YB
authors.lastname: Kiran
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Takeda
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Sakai
authors.affiliation: Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan; Center for Technologies Against Cancer, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan. Electronic address: konaka@rs.noda.tus.ac.jp.
authors.forename: Takeo
authors.initials: T
authors.lastname: Konakahara
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004611:Ellipticines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D004611:Ellipticines; C034192:ellipticine
keywords: 6H-pyrido[4,3-b]carbazole; Antitumor activity; Cytotoxicity; Ellipticine; HeLa S-3; Nitrosourea; SAR; Synthesis