title: Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis.
abstract: This study demonstrated that 0.5% dietary rutin, ellagic acid, or curcumin markedly increased cecal succinate levels in rats fed a high-fat diet, whereas catechin, caffeic acid, and quercetin did not. Other organic acids were modestly or hardly affected by polyphenols. To clarify the effects of succinate levels increased by polyphenols, this study examined the effects of succinate on the growth and proliferation of colon cancer cells and angiogenesis. The growth and proliferation of HT29 human colon cancer cells and angiogenesis in an ex vivo model were significantly inhibited by succinate at a dose close to that in the cecum of rats fed polyphenols. Furthermore, succinate inhibited the migration of human umbilical vein endothelial cells. These findings suggest that the consumption of some polyphenols affects the health and diseases of the large intestine by elevating succinate.
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University , 1-4-4 Higashi, Hiroshima 739-8528, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Haraguchi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kayashima
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Junji
authors.initials: J
authors.lastname: Inoue
authors.forename: Shigeru
authors.initials: S
authors.lastname: Mineo
authors.forename: Kiminori
authors.initials: K
authors.lastname: Matsubara
authors.forename: Ei
authors.initials: E
authors.lastname: Sakaguchi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yanaka
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
mesh_terms: D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology; D002392:Catechin / Q000494:pharmacology; D002432:Cecum / Q000737:chemistry / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D003474:Curcumin / Q000494:pharmacology; D059305:Diet, High-Fat; D004610:Ellagic Acid / Q000494:pharmacology; D019073:HT29 Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008297:Male; D059808:Polyphenols / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012431:Rutin / Q000494:pharmacology; D019802:Succinic Acid / Q000737:chemistry*
chemical_list: D002109:Caffeic Acids; D059808:Polyphenols; D004610:Ellagic Acid; D012431:Rutin; D002392:Catechin; D011794:Quercetin; D019802:Succinic Acid; D003474:Curcumin; C040048:caffeic acid