title: A novel SWCNT platform bearing DOTA and β-cyclodextrin units. "One shot" multidecoration under microwave irradiation.
abstract: The functionalization of single-walled carbon nanotubes (SWCNTs) via microwave-assisted grafting reactions enables efficient multidecoration in a single step. A novel water-soluble SWCNT platform was prepared via the simple 1,3-dipolar cycloaddition of azomethine ylides under dielectric heating. Thanks to a single grafting reaction the CNT surface binds in a 1 : 1 ratio an amino acidic β-cyclodextrin (β-CD) derivative and the DOTAMA moiety (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid monoamide). This novel "one shot" synthesis, compared with multistep functionalizations, preserves the SWCNT's structural integrity (TEM images). Besides thermogravimetric analyses, the determination of the amount of β-CD and DOTA moieties grafting onto the SWCNT's surface was performed on the basis of phenolphthalein and gadolinium complexation, respectively.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, and Interdepartmental Centre "Nanostructured Interfaces and Surfaces" - NIS, University of Turin, Via P. Giuria 9, 10125 Torino, Italy. giancarlo.cravotto@unito.it.
authors.forename: E
authors.initials: E
authors.lastname: Calcio Gaudino
authors.forename: S
authors.initials: S
authors.lastname: Tagliapietra
authors.forename: K
authors.initials: K
authors.lastname: Martina
authors.forename: A
authors.initials: A
authors.lastname: Barge
authors.forename: M
authors.initials: M
authors.lastname: Lolli
authors.forename: E
authors.initials: E
authors.lastname: Terreno
authors.forename: D
authors.initials: D
authors.lastname: Lembo
authors.forename: G
authors.initials: G
authors.lastname: Cravotto
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D002625:Chemistry, Organic / Q000379:methods*; D061565:Cycloaddition Reaction; D003653:Decarboxylation; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D006801:Humans; D008872:Microwaves; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D037742:Nanotubes, Carbon; D047392:beta-Cyclodextrins; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; C031215:betadex