title: Prevalence of elevated glycated hemoglobin concentrations in the polycystic ovary syndrome: anthropometrical and metabolic relationship in amazonian women.
abstract: BACKGROUND
  To determine the prevalence of elevated glycated hemoglobin (HbA1c) and to examine its relationship with other carbohydrate metabolic parameter among Brazilian women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  A cross-sectional study including 288 PCOS patients was conducted. Anthropometrical, clinical, biochemical and endocrine parameters were evaluated.
  
  
  RESULTS
  The mean age was 26.92 ± 5.51 years. HbA1c mean concentration was 5.83±1.34%. In 38.54% of patients, HbA1c was ≥ 5.7%. HbA1c was positively correlated with body weight (r = 0.142, P = 0.017), body mass index (P = 0.000), waist:hip ratio (P = 0.000), fat mass (P = 0.000), conicity index (P = 0.000), triglyceride (P = 0.001), C-peptide (P = 0.000), total testosterone (P = 0.003), free testosterone (P = 0.000), free androgen index (P = 0.006) and fasting insulin (P = 0.025). Using the oral glucose tolerance test, HbA1c showed positive correlation with glucose concentrations at any point in time (P < 0.05).
  
  
  CONCLUSIONS
  HbA1c was elevated in nearly 40% of PCOS patients and it showed positive correlation with several anthropometric and metabolic factors and androgen levels. The current study provides further evidence that HbA1C is higher in PCOS patients and may have a potential role in the prediction of dysglycemic disease in these women.
authors.affiliation: Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, 78055-728 Cuiaba, MT, Brazil ; Tropical Institute of Reproductive Medicine and Menopause, 78043-306 Cuiaba, MT, Brazil.
authors.forename: Sebastiao Freitas
authors.initials: SF
authors.lastname: de Medeiros
authors.affiliation: Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, 78055-728 Cuiaba, MT, Brazil ; Tropical Institute of Reproductive Medicine and Menopause, 78043-306 Cuiaba, MT, Brazil.
authors.forename: Marcia Marly Winck
authors.initials: MM
authors.lastname: Yamamoto
authors.affiliation: Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, 78055-728 Cuiaba, MT, Brazil.
authors.forename: Herica Bernardes
authors.initials: HB
authors.lastname: Bueno
authors.affiliation: Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, 78055-728 Cuiaba, MT, Brazil.
authors.forename: Danilla
authors.initials: D
authors.lastname: Belizario
authors.affiliation: Tropical Institute of Reproductive Medicine and Menopause, 78043-306 Cuiaba, MT, Brazil.
authors.forename: Jacklyne Silva
authors.initials: JS
authors.lastname: Barbosa
keywords: Glycated hemoglobin; Impaired glucose tolerance; Polycystic ovary syndrome