title: The effect of extending dinoprostone pessary placement from 12 to 24 h on the need for further mechanical cervical ripening.
abstract: Dinoprostone pessaries (DP) are widely used for cervical ripening, and while licensed for 12-h administration in Australia, 24-h use is also reported. We examined 396 consecutive women before and after a protocol change from 12-h to 24-h DP use to determine whether extended DP use decreases the need for additional mechanical cervical ripening. No significant difference in cervical ripening balloon (CRB) requirement or vaginal birth rates was detected, showing that prolonged DP use does not reduce subsequent use of CRB.
authors.affiliation: Department of Obstetrics and Gynaecology, The Maitland Hospital, Maitland, Australia.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Lusink
authors.forename: Leila
authors.initials: L
authors.lastname: Usher
authors.forename: Tania
authors.initials: T
authors.lastname: Day
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D020070:Cervical Ripening / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics / Q000008:administration & dosage*; D010570:Pessaries; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D010120:Oxytocics; D015232:Dinoprostone
keywords: cervical dilatation; cervical ripening; dinoprostone; induced labour; intravaginal drug administration