title: The first case of acinic cell carcinoma of the breast within a fibroadenoma: case report.
abstract: A case of acinic cell carcinoma of the breast is reported in a 26-year-old woman. She presented a lump in her right breast, that seemed to be a fibroadenoma. The open biopsy revealed a well-bordered fibroadenoma, together with a proliferation of cells characterized by serous acinar differentiation and eosinophilic cytoplasmic granules. Tumor cells stained for amylase, lysozyme, α-1-antichymotripsin, epithelial membrane antigen, S-100 protein, pan-cytokeratin, cytokeratin 7 and E-cadherin. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 overexpression, CD10, P63, smooth muscle actin, cytokeratin 5/6 were negative. The sentinel node was negative. 8 months after surgery she is in good clinical conditions without recurrence or metastases.
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Limite
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy. Electronic address: rosadimicco@alice.it.
authors.forename: R
authors.initials: R
authors.lastname: Di Micco
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Esposito
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Sollazzo
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cervotti
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pettinato
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Varone
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Benassai
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Monda
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Luglio
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Maisto
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Izzo
authors.affiliation: Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Forestieri
mesh_terms: D000328:Adult; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy; D009378:Neoplasms, Multiple Primary; D016217:Ultrasonography, Mammary
keywords: Acinic cell carcinoma; Breast cancer; Eosinophilic cytoplasmic granules