title: Early treatment response monitoring using 2-deoxy-2-[ 18F]fluoro-D-glucose positron emission tomography imaging during fractionated radiotherapy of head neck cancer xenografts.
abstract: BACKGROUND
  To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control.
  
  
  METHODS
  Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki).
  
  
  RESULTS
  Four xenografts had local failure (LF) and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF.
  
  
  CONCLUSIONS
  RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control.
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Chunta
authors.affiliation: Department of Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA.
authors.forename: Mitual
authors.initials: M
authors.lastname: Amin
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: David Y
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: Inga S
authors.initials: IS
authors.lastname: Grills
authors.affiliation: Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA.
authors.forename: Ching-Yee
authors.initials: CY
authors.lastname: Oliver Wong
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Marples
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: Di
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA.
authors.forename: George D
authors.initials: GD
authors.lastname: Wilson
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D019583:Dose Fractionation, Radiation; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D064593:Heterografts; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D049268:Positron-Emission Tomography / Q000379:methods*; D011859:Radiography; D019275:Radiopharmaceuticals / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18