title: Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges.
abstract: This review highlights studies conducted in murine models to evaluate the efficacy of compounds targeting Heat shock protein (Hsp) 90 of malaria. Both advances achieved and limitations that exist are highlighted.
authors.affiliation: Department of Microbiology, Immunology and Infectious Diseases, Faculty of Medicine,University of Calgary,Calgary, AB T2L 2K8,Canada.
authors.forename: Abebe Genetu
authors.initials: AG
authors.lastname: Bayih
authors.affiliation: Department of Microbiology, Immunology and Infectious Diseases, Faculty of Medicine,University of Calgary,Calgary, AB T2L 2K8,Canada.
authors.forename: Dylan R
authors.initials: DR
authors.lastname: Pillai
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000502:physiology*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D010963:Plasmodium falciparum / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D000962:Antimalarials; D018841:HSP90 Heat-Shock Proteins; D015800:Protozoan Proteins