title: AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855.
abstract: A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent extraction, HP-20 and ODS-B column chromatography and crystallization, and was determined to have the molecular formula C25H41NO7. AS2077715 has a structure related to that of funiculosin, an inhibitor of mitochondrial cytochrome bc1 complex (complex III), and showed antifungal activity against Trichophyton species.
authors.affiliation: Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ohsumi
authors.affiliation: Fermentation Research Division, Astellas Research Technologies Co., Ltd., Ibaraki, Japan.
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Masaki
authors.affiliation: Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.affiliation: Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujie
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology*; D016000:Cluster Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D020459:Genes, rRNA; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010802:Phylogeny; D012331:RNA, Fungal / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics; D017422:Sequence Analysis, DNA; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001688:Biological Products; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D004791:Enzyme Inhibitors; D012331:RNA, Fungal; D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S