title: Reducing the histopathological changes of radioiodine to the lacrimal glands by a popular anti-oxidant: lycopene.
abstract: OBJECTIVE
  Radioiodine (RAI) has been used for the treatment of hyperthyroidism and well-differentiated thyroid carcinoma for more than 70 years. Lycopene is an anti-oxidant, which is plentiful in red fruits. The purpose of this study was to investigate the possible inhibitory effect of lycopene on the RAI-induced acute histopathological changes in rat lacrimal glands.
  
  
  METHODS
  In this experimental animal study, 32 rats were randomly divided into three groups. The first group (control group, n = 8) was not given neither (131)I nor lycopene, the second group (RAI group, n = 12) was administrated a single dose of 3 mCi (131)I and 1 cc physiologic saline by gastric gavage. The third group (lycopene group, n = 12) was administrated 3 mCi (131)I and 1 cc lycopene by gastric gavage. After 24 h of the last dose, the animals were decapitated on the seventh day and their lacrimal glands were removed for histopathological examination.
  
  
  RESULTS
  The cell shape and the cell size variation and poorly defined acidophilic cell outlines in all lacrimal glands were observed significantly less frequently in the lycopene group than in the RAI group.
  
  
  CONCLUSIONS
  Our histopathological examinations have revealed that lycopene prevents rat lacrimal glands against RAI-related acute histopathological changes.
authors.affiliation: Department of Ophthalmology, Ministry of Health, Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey .
authors.forename: Damla Erginturk
authors.initials: DE
authors.lastname: Acar
authors.forename: Ugur
authors.initials: U
authors.lastname: Acar
authors.forename: Nihat
authors.initials: N
authors.lastname: Yumusak
authors.forename: Meliha
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Mutlu
authors.initials: M
authors.lastname: Acar
authors.forename: Hasan Ikbal
authors.initials: HI
authors.lastname: Atilgan
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Yalniz-Akkaya
authors.forename: Gokhan
authors.initials: G
authors.lastname: Koca
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics; D002338:Carotenoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005751:Gastric Lavage / Q000379:methods; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007765:Lacrimal Apparatus / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D007766:Lacrimal Apparatus Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000077276:Lycopene; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D007457:Iodine Radioisotopes; D002338:Carotenoids; D000077276:Lycopene
keywords: Anti-oxidant; lacrimal glands; lycopene; radioiodine; radioprotection; rat