title: The significance of serum phosphate level on healing index and its relative effects in skeletally immature and mature patients with hypophosphatemic rickets.
abstract: The aim of this study was to find out the ideal cut-off level of phosphate for safe healing when deformity correction and concomitant lengthening are indicated in the two different skeletal maturity groups of patients with rickets. Thirty-nine hypophosphatemic rickets patients were selected for the study and were divided into two groups: 27 skeletally immature (group IM) and 12 skeletally mature (group M). The outcomes were evaluated with respect to the healing index (HI), laboratory findings, and complications with the mean follow-up of 5.1 years (range, 3.1-7.9). The healing index (HI) of group IM was 1.44 month/cm and HI of group M was 1.68 month/cm. The negative correlation between the level of serum phosphate and HI in group M (coefficient=-0.94) was evaluated to be less than the correlation in group IM (coefficient=-0.50), indicating that the HI is more likely to be affected by serum phosphate in group M than in group IM. Preoperative serum phosphate levels of 2.3 mg/dL and 2.6 mg/dL were analyzed to be the cut-off values of group IM and group M, respectively, in which the cut-off points divided the series into two groups having the most significantly different HI.
authors.affiliation: Department of Orthopaedic Surgery, Myongji Hospital, 55 Hwasu-ro 14 Beon-gil, Deokyang-gu, Goyang 412-826, Republic of Korea.
authors.forename: Sang-Heon
authors.identifier: 0000-0003-1160-0696
authors.initials: SH
authors.lastname: Song
authors.affiliation: Department of Orthopaedic Surgery and Rare Diseases Institute, Korea University Medical Center, Guro Hospital, 80 Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea.
authors.forename: Hanna
authors.identifier: 0000-0002-1782-3092
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Orthopaedic Surgery and Rare Diseases Institute, Korea University Medical Center, Guro Hospital, 80 Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Jeong
authors.affiliation: Department of Orthopaedic Surgery, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do 420-767, Republic of Korea.
authors.forename: Woo-In
authors.initials: WI
authors.lastname: Cho
authors.affiliation: Department of Orthopaedic Surgery and Rare Diseases Institute, Korea University Medical Center, Guro Hospital, 80 Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery and Rare Diseases Institute, Korea University Medical Center, Guro Hospital, 80 Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea.
authors.forename: Hae-Ryong
authors.initials: HR
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005269:Femur / Q000473:pathology; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood*; D012189:Retrospective Studies; D063730:Rickets, Hypophosphatemic / Q000097:blood*; D013977:Tibia / Q000473:pathology; D055815:Young Adult
chemical_list: D010710:Phosphates