title: High concentrations of glucose suppress etoposide-induced cell death of B-cell lymphoma through BCL-6.
abstract: Glucose is potentially a factor in the resistance to chemotherapy of B-cell lymphomas. In this study we investigated the expression of the glucose induced transcription factor Bcl-6 and the underlying mechanism by which it suppresses B-cell lymphoma cell death. Glucose was found to prevent etoposide-induced tumor cell death. BCL-6 expression was induced by glucose but down-regulated by etoposide. BCL-6 expression was regulated by the interaction of VDUP1 and p53. The molecular mechanism by which glucose prevented etoposide-induced tumor cell death was shown to involve the BCL-6 mediated caspase pathway. Our data suggest that glucose-induced BCL-6 overexpression could abrogate the etoposide chemotherapy effect on tumor cell death.
authors.affiliation: Cell Therapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Republic of Korea; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region. Electronic address: wellshao@gmail.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, China. Electronic address: lingcc@connect.hku.hk.
authors.forename: Chang Chun
authors.initials: CC
authors.lastname: Ling
authors.affiliation: Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region.
authors.forename: Xu Qing
authors.initials: XQ
authors.lastname: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects; D002352:Carrier Proteins / Q000378:metabolism; D020169:Caspases / Q000378:metabolism*; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005047:Etoposide / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology*; D051560:Proto-Oncogene Proteins c-bcl-6
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C084103:BCL6 protein, human; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; C486715:TXNIP protein, human; D005047:Etoposide; D020169:Caspases; D005947:Glucose
keywords: B-cell lymphoma; BCL-6; Chemotherapy; Etoposide; Glucose