title: Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries.
abstract: In coronary artery bypass grafting (CABG), the combined use of left and right internal mammary arteries (LIMA and RIMA) - collectively known as bilateral IMAs (BIMAs) provides a survival advantage over the use of LIMA alone. However, gene expression in RIMA has never been compared to that in LIMA. Here we report a genome-wide transcriptional analysis of BIMA to investigate the expression profiles of these conduits in patients undergoing CABG. As expected, in comparing the BIMAs to the aorta, we found differences in pathways and processes associated with atherosclerosis, inflammation, and cell signaling - pathways which provide biological support for the observation that BIMA grafts deliver long-term benefits to the patients and protect against continued atherosclerosis. These data support the widespread use of BIMAs as the preferred conduits in CABG.
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA; University of Pennsylvania, Department of Surgery, Glenolden, PA 19036, USA.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ferrari
authors.affiliation: Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: John
authors.initials: J
authors.lastname: Quackenbush
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA.
authors.forename: John
authors.initials: J
authors.lastname: Strobeck
authors.affiliation: Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Lan
authors.initials: L
authors.lastname: Hu
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Johnson
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Mak
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Shaw
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Sayles
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA; Columbia University College of Physicians and Surgeons, Department of Surgery, New York, NY 10032, USA.
authors.forename: Mariano E
authors.initials: ME
authors.lastname: Brizzio
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA; Columbia University College of Physicians and Surgeons, Department of Surgery, New York, NY 10032, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Zapolanski
authors.affiliation: The Valley Columbia Heart Center, 223 North Van Dien Avenue Ridgewood, NJ 07450, USA; Columbia University College of Physicians and Surgeons, Department of Surgery, New York, NY 10032, USA. Electronic address: jbg2136@cumc.columbia.edu.
authors.forename: Juan B
authors.initials: JB
authors.lastname: Grau
mesh_terms: D000368:Aged; D001011:Aorta / Q000378:metabolism; D001026:Coronary Artery Bypass / Q000379:methods; D005260:Female; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000378:metabolism*; D008875:Middle Aged; D009928:Organ Specificity; D059467:Transcriptome
keywords: Cardiovascular disease; Coronary artery bypass grafting; Genomics; Transcriptome analysis