title: MicroRNAs in Experimental Models of Movement Disorders.
abstract: MicroRNAs (miRNAs) are small RNAs comprised of 20-25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as oncology, immunology, and cardiovascular diseases. In Parkinson's disease and related disorders, multiple studies have identified the implications of specific miRNAs and the polymorphisms of miRNA target genes during the disease pathogenesis. With a focus on Parkinson's disease, spinocerebellar ataxia, hereditary spastic paraplegia, and Huntington's disease, this review summarizes and interprets the observations, and proposes future research topics in this field.
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul National University, College of Medicine, Seoul, Korea.
authors.forename: Soon-Tae
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul National University, College of Medicine, Seoul, Korea.
authors.forename: Manho
authors.initials: M
authors.lastname: Kim
keywords: Hereditary spastic paraplegia; Huntington’s disease; MicroRNA; Parkinson’s disease; Spinocerebellar ataxia