title: Direct metal-catalyzed regioselective functionalization of enamides.
abstract: Enamides are stable enamine surrogates and provide key intermediates for the synthesis of small but complex nitrogen-containing compounds. Metal-catalyzed regioselective functionalization of enamides provides a rapid method to synthesize useful nitrogen containing heterocycles. This review discloses the recent progress made in the development of the C-H functionalization of enamides involving efficient and atom-economical routes. Syntheses of different heterocycles are classified based on the site reactivity of enamides and key mechanistic insights are given for each transformation.
authors.affiliation: Institut de Chimie Organique et Analytique, UMR 7311, CNRS, Université d'Orléans, rue de Chartres, 45067 Orléans cedex 2 (France), Fax: (+33) 2-38-41-72-81.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gigant
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Chausset-Boissarie
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gillaizeau
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009584:Nitrogen; D013237:Stereoisomerism
chemical_list: D000577:Amides; D009584:Nitrogen
keywords: CH functionalization; atom economy; enamides; heterocycles; metal catalysis