title: Association of intracranial pressure with outcome in comatose patients with intracerebral hemorrhage.
abstract: BACKGROUND
  Therapeutic targets for intracranial pressure (ICP) in patients with severe intracerebral hemorrhage (ICH) are approximated from data of traumatic brain injury. However, specific data for ICH are lacking. Here, we aimed to investigate the association between ICP, mortality and functional outcome following severe ICH.
  
  
  METHODS
  We analyzed consecutive comatose patients with ICH in whom ICP monitoring was applied. Outcome at 3 months was assessed using the modified Rankin scale (mRS). Multivariate logistic regression including pre-defined predictors was used in order to identify the effects of ICP on outcome.
  
  
  RESULTS
  121 patients with ICH and ICP monitoring were analyzed. Mean ICP (OR 1.2, CI 1.08-1.45, p=0.003), ICP variability (OR 1.3, CI 1.03-1.73, p=0.03) and relative frequency of ICP values >20 mm Hg (OR 1.1, CI 1.02- 1.15, p=0.008) were independently associated with mortality at 3 months. Relative frequency of ICP values >20 mm Hg (OR 1.1, CI 1.001-1.3, p=0.04) was associated also with poor functional outcome at 3 months.
  
  
  CONCLUSIONS
  Our data suggest that in the context of other predictors as age, admission clinical status, hemorrhage volume and intraventricular hemorrhage, average ICP, ICP variability and the frequency of ICP values >20 mm Hg are independently associated with mortality and poor outcome after ICH. Further studies and prospective validations of ICP thresholds for ICH patients are highly warranted.
authors.affiliation: Department of Neurology, University of Heidelberg, Heidelberg, Germany. Electronic address: marek.sykora@med.uni-heidelberg.de.
authors.forename: Marek
authors.initials: M
authors.lastname: Sykora
authors.affiliation: Department of Neurology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Sahra
authors.initials: S
authors.lastname: Steinmacher
authors.affiliation: Department of Neurology, Klinikum Frankfurt Höchst, Frankfurt am Main, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Steiner
authors.affiliation: Department of Neurology, University of Heidelberg, Heidelberg, Germany; Department of Neurology, University of Tübingen, Tübingen, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Poli
authors.affiliation: Department of Neurology, University of Heidelberg, Heidelberg, Germany; Department of Neurology, University of Tübingen, Tübingen, Germany; Department of Neurosurgery, University of Tübingen, Tübingen, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Diedler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications / Q000401:mortality* / Q000503:physiopathology*; D003128:Coma / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: CPP; Cerebral perfusion pressure; ICP; Intracerebral hemorrhage; Intracranial pressure; Outcome