title: Embryonic stem cell identity grounded in the embryo.
abstract: Pluripotent embryonic stem cells (ESCs) can be derived from blastocyst-stage mouse embryos. However, the exact in vivo counterpart of ESCs has remained elusive. A combination of expression profiling and stem cell derivation identifies epiblast cells from late-stage blastocysts as the source, and functional equivalent, of ESCs.
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Berenika
authors.initials: B
authors.lastname: Plusa
authors.affiliation: Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
authors.forename: Anna-Katerina
authors.initials: AK
authors.lastname: Hadjantonakis
mesh_terms: D000818:Animals; D053624:Blastocyst Inner Cell Mass / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000378:metabolism*; D005855:Germ Layers / Q000201:enzymology*; D039904:Pluripotent Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors