title: Determination serique de la crimidine par clhp/es/sm chez un patient ayant ingere un « souricide foudroyant ».
abstract: Crimidine (2 chloro, 4 methyl, 6 dimethyl amidopyrine) is a synthetic rodenticide which causes acute poisonings after oral ingestion in human. Major toxic effects are consciousness disorders, hypertonic coma and convulsions. Toxic level in human is about 5 mg/Kg. An intoxication case is reported. Five serums collected at different times were analyzed with HPLC/ ES/MS. Crimidine was extracted with ethylacetate with recovery over 80 %. Linearity was up to 800 μg/L. LOQ and LOD were 0.5 and 0.3 μg/L respectively. The coefficients of variation were less than 10 % for repeatability and reproductibility. Serum levels varied from 368 μg/L for H0 to 64 μg/L for H10 and elimination of crimidine was linear in time.
authors.affiliation: Unité Fonctionnelle de Toxicologie, Laboratoire de Biochimie et de Biologie Moléculaire, CHRU de Lille-59037 Lille Cedex.
authors.forename: T
authors.initials: T
authors.lastname: Besnard
authors.forename: N
authors.initials: N
authors.lastname: Sadeg
authors.forename: N
authors.initials: N
authors.lastname: Ricart
authors.forename: J
authors.initials: J
authors.lastname: Richecœur
authors.forename: P
authors.initials: P
authors.lastname: Nisse
authors.forename: E
authors.initials: E
authors.lastname: Vinner
authors.forename: N
authors.initials: N
authors.lastname: Houdret
authors.forename: L
authors.initials: L
authors.lastname: Humbert
authors.forename: M
authors.initials: M
authors.lastname: Lhermitte
keywords: CLHP/ES/SM,; Crimidine,; HPLC/ES/MS,; Rodenticide,; Toxicocinétique; Toxicokinetic.