title: Recurrent epistaxis following stabbing headache responsive to acetazolamide.
abstract: The co-occurrence of epistaxis and headache is not uncommon in migraine patients, although only few case reports have been published. A trigeminovascular activation may be causally involved although the exact mechanisms linking epistaxis and migraine remain unclear. Significant dural sinus stenosis may sustain or worsen an increased cerebral venous pressure and is considered a radiological predictor of idiopathic intracranial hypertension. We report a 49-year-old female patient with chronic migraine associated to stabbing headache-like attacks followed by epistaxis and by the resolution or the significant improvement of pain. As she also reported adjunctive symptoms suggestive of raised intracranial pressure and showed a bilateral narrowing of transverse sinuses at MR-venography, a possible intracranial hypertension was hypothesized despite the lack of papilledema. Acetazolamide 250 mg twice/day was added to therapy and the patient reported sudden reduction of headache severity and frequency and complete resolution of both the stabbing pain and the recurrent epistaxis, maintained for 5 months. At treatment discontinuation she complained the worsening of migraine headache and the reoccurrence of the superimposed stabbing pain followed by epistaxis. The mechanism linking the sequential occurrence of painful stabs, epistaxis and relief from pain with raised intracranial pressure in our patients remains unclear. We speculate that the sudden reopening of collapsed collateral veins of the anterior venous circle, possibly prompted by periodic waves of central venous hypertension coupled with intracranial hypertensive peaks, could explain the unusual strict time succession of painful stabs, epistaxis, and subsequent resolution of pain.
authors.affiliation: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University "Federico II" of Naples, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ranieri
authors.forename: A
authors.initials: A
authors.lastname: Topa
authors.forename: M
authors.initials: M
authors.lastname: Cavaliere
authors.forename: R
authors.initials: R
authors.lastname: De Simone
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D002908:Chronic Disease; D004844:Epistaxis / Q000150:complications* / Q000503:physiopathology; D005260:Female; D051270:Headache Disorders, Primary / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000503:physiopathology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide