title: Exercise and vascular function: how much is too much?
abstract: Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals at risk for cardiovascular disease, less is known about how exercise, especially intense exercise, affects vascular function in healthy individuals. This review highlights examples of how vascular function can paradoxically be impaired in otherwise healthy individuals by extreme levels of exercise, with a focus on the causative role that reactive oxygen species play in this impairment.
authors.affiliation: Department of Medicine, Cardiology Division, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Durand
authors.forename: David D
authors.initials: DD
authors.lastname: Gutterman
mesh_terms: D001808:Blood Vessels / Q000378:metabolism / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D057185:Sedentary Behavior
chemical_list: D017382:Reactive Oxygen Species; D009569:Nitric Oxide
keywords: dilatation dépendante du flux sanguin; espèces réactives d’oxygène; exercice; exercise; flow mediated dilation; nitric oxide; oxyde nitrique; reactive oxygen species; vasodilatation; vasodilation