title: Facet-specific assembly of proteins on SrTiO₃ polyhedral nanocrystals.
abstract: Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-specific assembly of proteins, such as albumin, immunoglobulin and protamine, on {100} facets of SrTiO3 polyhedral nanocrystals, while none on {110} facets. Molecular dynamics simulations indicate the immobile surface hydration layer might play a barrier role to effectively prevent proteins adsorption on specific {110} facets. This work thus provides new insights into the fundamentally understanding of protein-nanomaterial interactions, and open a novel, general and facile route to control the selective adsorption of various proteins on various nanocrystals.
authors.affiliation: 1] Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, China [2] Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Ningbo 315210, China [3].
authors.forename: Lingqing
authors.initials: L
authors.lastname: Dong
authors.affiliation: 1] Soft Matter Research Center and Department of Chemistry, Zhejiang University, Hangzhou 310027, China [2].
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.affiliation: 1] Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, China [2].
authors.forename: Kui
authors.initials: K
authors.lastname: Cheng
authors.affiliation: Soft Matter Research Center and Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.affiliation: Soft Matter Research Center and Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: 1] Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, China [2] Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Weng
authors.affiliation: 1] Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, China [2] Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Ningbo 315210, China [3] School of Physical Science and Technology, ShanghaiTech University.
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Han
mesh_terms: D000327:Adsorption; D000418:Albumins / Q000737:chemistry*; D007136:Immunoglobulins / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D011479:Protamines / Q000737:chemistry*; D013324:Strontium / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000418:Albumins; D007136:Immunoglobulins; D010087:Oxides; D011479:Protamines; D014025:Titanium; C119252:strontium titanium oxide; D013324:Strontium