title: Changes in PKM2 associate with prostate cancer progression.
abstract: Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression.
authors.affiliation: Division of Nephrology, Department of Medicine, McMaster University,1.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wong
authors.forename: Judy
authors.initials: J
authors.lastname: Yan
authors.forename: Diane
authors.initials: D
authors.lastname: Ojo
authors.forename: Jason
authors.initials: J
authors.lastname: De Melo
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Cutz
authors.forename: Damu
authors.initials: D
authors.lastname: Tang
mesh_terms: D000368:Aged; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D020022:Genetic Predisposition to Disease; D006019:Glycolysis / Q000235:genetics; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008875:Middle Aged; D060787:Neoplasm Grading; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology*; D011499:Protein Processing, Post-Translational; D013963:Thyroid Hormones / Q000235:genetics* / Q000378:metabolism; D000097810:Thyroid Hormone-Binding Proteins
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins
keywords: Cancer Metabolism; PKM2; Prostate cancer