title: The effect of anodal transcranial direct current stimulation over the primary motor or somatosensory cortices on somatosensory evoked magnetic fields.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of anodal transcranial direct-current stimulation (tDCS) applied over the primary motor (M1) or the primary somatosensory (S1) cortices on somatosensory evoked magnetic fields (SEFs) following median nerve stimulation.
  
  
  METHODS
  Anodal tDCS was applied for 15min on the left motor or somatosensory cortices at 1mA. SEFs were recorded following right median nerve stimulation using a magnetoencephalography (MEG) system before and after the application of tDCS. SEFs was measured and compared before and after tDCS was applied over M1 or S1.
  
  
  RESULTS
  The source strengths for the P35m and P60m increased after tDCS was applied over M1 and that for the P60m increased after tDCS was applied over S1. The mean equivalent current dipole (ECD) location for the P35m was located significantly anterior to that of the N20m, but only during post 1 (10-20min after tDCS was applied over M1).
  
  
  CONCLUSIONS
  Our results indicated that the anodal tDCS applied over M1 affected the P35m and P60m sources on SEF components, while that applied over S1 influenced the P60m source.
  
  
  CONCLUSIONS
  We demonstrated anodal tDCS applied over M1 or S1 can modulate somatosensory processing and components of SEFs, confirming the hypothesis for locally distinct generators of the P35m and P60m sources.
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan. Electronic address: sugawara@nuhw.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugawara
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Onishi
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Koya
authors.initials: K
authors.lastname: Yamashiro
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Kojima
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Miyaguchi
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Hikari
authors.initials: H
authors.lastname: Kirimoto
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Tsubaki
authors.affiliation: Institute for Human Movement & Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tamaki
authors.affiliation: Department of Neurosurgery, Nishi-Niigata Chuo National Hospital, 14-1-1 Masago, Nishi-ku, Niigata 950-2085, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shirozu
authors.affiliation: Department of Neurosurgery, Nishi-Niigata Chuo National Hospital, 14-1-1 Masago, Nishi-ku, Niigata 950-2085, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kameyama
mesh_terms: D000328:Adult; D004558:Electric Stimulation / Q000379:methods; D004566:Electrodes; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation / Q000295:instrumentation* / Q000379:methods*; D055815:Young Adult
keywords: Magnetoencephalography; Median nerve stimulation; Primary motor cortex; Primary somatosensory cortex; Somatosensory evoked magnetic fields; Transcranial direct current stimulation