title: Genetic variants associated with susceptibility of Ashkenazi Jews to West Nile virus infection.
abstract: The epidemiology of West Nile virus (WNV) in Israel is different from other neighbouring countries in the Middle East where disease burden has been minimal. We analysed a cohort of Ashkenazi Jewish patients with symptomatic WNV infection (n = 39), and WNV-negative controls (n = 61), for nine genetic variants that has been suggested to be associated with susceptibility to WNV. Two single nucleotide polymorphisms were significantly more frequent in WNV-infected than non-infected individuals, rs7280422 (MX1) [odds ratio (OR) 4·05, 95% confidence interval (CI) 2·04-8·03, P < 0·001] and rs3213545 (OASL) (OR 1·85, 95% CI 1·03-3·3, P = 0·03). Genetic polymorphism may play a significant role in susceptibility to WNV infection in Ashkenazi Jews.
authors.affiliation: Institute of Genetics,Emek Medical Centre, Afula,Israel.
authors.forename: N
authors.initials: N
authors.lastname: Danial-Farran
authors.affiliation: Department of Medicine D,Emek Medical Centre,Afula,Israel.
authors.forename: S
authors.initials: S
authors.lastname: Eghbaria
authors.affiliation: Clinical Research Unit,Emek Medical Centre,Afula,Israel.
authors.forename: N
authors.initials: N
authors.lastname: Schwartz
authors.affiliation: Virology Laboratory,Rambam Health Care campus, Haifa,Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Kra-Oz
authors.affiliation: Department of Medicine D,Emek Medical Centre,Afula,Israel.
authors.forename: N
authors.initials: N
authors.lastname: Bisharat
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007557:Israel; D007585:Jews / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014901:West Nile Fever / Q000235:genetics*; D014902:West Nile virus; D055815:Young Adult
keywords: West Nile virus