title: Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism.
abstract: OBJECTIVE
  To investigate cardiovascular risk factors in women with polycystic ovary syndrome (PCOS) combined with subclinical hypothyroidism (SCH).
  
  
  METHODS
  A place-controlled study was performed. Group 1: 29 patients with PCOS and SCH; Group II: 35 patients with PCOS and normal thyroid function; and Group III: 34 healthy women with normal thyroid function. MAIN MEASURE INDEXES: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), Carotid Arterial Intima-Media Thickness (CIMT), free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid stimulating hormone (TSH), fasting glucose, 1-hour oral glucose tolerance test (OGTT1), 2-hour oral glucose tolerance test (OGTT2), fasting insulin, insulin after 1 hour oral glucose (INS1), insulin after 2 h oral glucose (INS2), HOM-IR = (fasting glucose × fasting insulin)/22.5.
  
  
  RESULTS
  TG, TC FIN, INS1, and HOM-IR levels were significantly higher, but the mean HDL level was significantly lower in Group I than in Group II (p < 0.05). LDL cholesterol, FGOGTT1, OGTT2, and insulin after 2 h oral glucose were not significantly higher in Group I than in Group II (p > 0.05). TG, TC, FIN and INS contents 2 h meal, HOM-IR levels were significantly higher, and the mean HDL cholesterol level was significantly lower in Group I than in Group III (p < 0.05). Blood glucose levels after 1 and 2 h were not significantly higher in Group I than in the Group III (p > 0.05). Carotid Arterial Intima-Media Thickness (CIMT) was significantly thicker in Group I than other two groups.
  
  
  CONCLUSIONS
  The PCOS patients combined with SCH have higher risk of cardiovascular risk factors than in controls or in patients with PCOS.
authors.affiliation: Reproductive Medical Center of Navy General Hospital, Hai Dian District , Beijing , China .
authors.forename: You-Juan
authors.initials: YJ
authors.lastname: Pei
authors.forename: Ai-Ming
authors.initials: AM
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Yan
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Richard E
authors.initials: RE
authors.lastname: White
authors.forename: Gui Chun
authors.initials: GC
authors.lastname: Han
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012307:Risk Factors; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D008055:Lipids; D013963:Thyroid Hormones; D013972:Thyrotropin
keywords: Blood pressure; carotid arterial intima-media thickness; insulin release test; lipid parameters; oral glucose tolerance test; polycystic ovary syndrome; resting heart rate; subclinical hypothyroidism