title: Significance of the plasma lipid profile in cases of carcinoma of cervix: a tertiary hospital based study.
abstract: OBJECTIVE
  To study alterations of plasma lipid profiles in carcinoma cervix and to assess significance compared with controls in different histological grades and stages.
  
  
  METHODS
  Totals of 99 histopathologically diagnosed cases and 35 controls from a tertiary hospital situated in the southern part of India which caters the rural and semi-urban populations were considered for the study. Fasting blood samples were taken to analyze total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoproteins cholesterol (LDL-C), for comparison of cases, grouped according to histological grades and stages, and controls. One way ANOVA was used for multiple group comparisons and the Student's t test (unpaired) for group wise comparisons. For all tests a 'p' value of 0.05 or less was considered as significant.
  
  
  RESULTS
  Out of 99 cases, most (n-39) were seen in the 40-49 year age group followed by 60-69 years (n-22). Serum TG significantly differed between cases and controls but without any relation to differentiation grade. The lipid profile parameters in various grades of cervical cancer were not statistically significant. Statistically significant increase of TC and LDL-C values was observed with increase in stage of the disease.
  
  
  CONCLUSIONS
  The study showed TG is elevated in cervical cancer, and that TC and LDL-C are proportional to the spread of cancer as it increases from stage I to stage IV. An in-depth study of molecular changes in lipid metabolism in cervical cancer patients, enzymes/ genes responsible and alterations in LDL receptors is necessary to provide information to decide whether the lipid profile has any diagnostic/prognostic role in cervical cancer.
authors.affiliation: Department of Pathology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India E-mail : drkalyanir@rediffmail.com.
authors.forename: Kalyani
authors.initials: K
authors.lastname: Raju
authors.forename: Shruthi Suresh
authors.initials: SS
authors.lastname: Punnayanapalya
authors.forename: Narayanaswamy
authors.initials: N
authors.lastname: Mariyappa
authors.forename: Sumathi Mayagondanahalli
authors.initials: SM
authors.lastname: Eshwarappa
authors.forename: Chandramouli
authors.initials: C
authors.lastname: Anjaneya
authors.forename: Lee Jun
authors.initials: LJ
authors.lastname: Kai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D062606:Tertiary Care Centers; D014280:Triglycerides / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol