title: Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.
abstract: The aim of this study was to investigate the associations between STAT5 gene polymorphisms and glioblastoma (GBM) risk predisposition. We undertook a case-control study to analyze two STAT5 polymorphisms (STAT5a rs11079041 and STAT5b rs2293157) in a Han Chinese population, by extraction of genomic DNA from the peripheral blood of 328 patients with glioma and 342 control participants, and performed STAT5 genotyping using DNA sequencing. The obtained results indicated that overall, no statistically significant association was observed in STAT5a rs11079041. Nevertheless, STAT5b rs2293157 G/T genotype was at increased risk of glioma (P=0.001). Furthermore, rs2293157T allele was more significantly prognostic in patients suffering from glioblastoma compared to other subtypes of gliomas (P<0.001; odds ratio (OR)=5.14, CI 95%: 2.70-9.79). These findings led us to conclude that polymorphism in STAT5b rs2293157 G/T was observed to be associated with susceptibility of glioblastoma. Nevertheless, further investigation with a later confirmation in another ethnical or geographical cohort is required.
authors.affiliation: Department of Neurosurgery, Qilu Hospital of Shandong University, 107 Wenhua Western Road, Jinan, Shandong 250012, China; Department of Neurosurgery, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong, China.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, People's Hospital of Binzhou City, Binzhou, Shandong, China.
authors.forename: Hong-En
authors.initials: HE
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, Qilu Hospital of Shandong University, 107 Wenhua Western Road, Jinan, Shandong 250012, China. Electronic address: drdoctorligang@163.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D050799:STAT5 Transcription Factor / Q000235:genetics*
chemical_list: D050799:STAT5 Transcription Factor
keywords: Allele; Glioblastoma; Polymorphism; STAT5