title: Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent.
abstract: A water-stable phosphoramidate Ru(arene) metallodrug shows antiproliferative activity comparable to KP1019 in human cancer cell lines. This novel compound can cross-link the peptide backbone of cytochrome c, but features low apoptosis inducing properties.
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Meier
authors.forename: Maria S
authors.initials: MS
authors.lastname: Novak
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kandioller
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jakupec
authors.forename: Alexander
authors.initials: A
authors.lastname: Roller
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Keppler
authors.forename: Christian G
authors.initials: CG
authors.lastname: Hartinger
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D045304:Cytochromes c / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010756:Phosphoric Acids / Q000737:chemistry / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010756:Phosphoric Acids; D011753:Pyrones; D012428:Ruthenium; D045304:Cytochromes c; C011067:phosphoramidic acid