title: Evaluation of the DDSolver software applications.
abstract: When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This report aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained from dissolution experiments. The data used in this report were chosen from two dissolution studies. The results of the DDSolver analysis were compared with those obtained using an Excel worksheet. The comparisons among three different products obtained similarity factors (f 2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet. The results differed when DDSolver and Excel were used to calculate the release exponent "n" in the Korsmeyer-Peppas model. Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet. The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.
authors.forename: Jieyu
authors.identifier: 0000-0001-8097-2173
authors.initials: J
authors.lastname: Zuo
authors.affiliation: Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Yuan
authors.identifier: 0000-0003-3681-0411
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508-000 Sao Paulo, SP, Brazil.
authors.forename: Nadia
authors.initials: N
authors.lastname: Bou-Chacra
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.
authors.forename: Raimar
authors.initials: R
authors.lastname: Löbenberg
mesh_terms: D065546:Drug Liberation; D006801:Humans; D008962:Models, Theoretical; D012984:Software