title: Nuclear distribution of RNA polymerase II and mRNA processing machinery in early mammalian embryos.
abstract: Spatial distribution of components of nuclear metabolism provides a significant impact on regulation of the processes of gene expression. While distribution of the key nuclear antigens and their association with the defined nuclear domains were thoroughly traced in mammalian somatic cells, similar data for the preimplantation embryos are scanty and fragmental. However, the period of cleavage is characterized by the most drastic and dynamic nuclear reorganizations accompanying zygotic gene activation. In this minireview, we try to summarize the results of studies concerning distribution of major factors involved in RNA polymerase II-dependent transcription, pre-mRNA splicing mRNA export that have been carried out on early embryos of mammals.
authors.affiliation: Laboratory of Cell Morphology, Institute of Cytology RAS, 4 Tikhoretsky Avenue, St. Petersburg 194064, Russia.
authors.forename: Irina O
authors.initials: IO
authors.lastname: Bogolyubova
authors.affiliation: Laboratory of Cell Morphology, Institute of Cytology RAS, 4 Tikhoretsky Avenue, St. Petersburg 194064, Russia.
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Bogolyubov
mesh_terms: D000818:Animals; D000941:Antigens / Q000378:metabolism; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000276:immunology* / Q000378:metabolism; D005091:Exons; D005260:Female; D008297:Male; D051379:Mice; D008856:Microscopy, Fluorescence; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation; D012319:RNA Polymerase II / Q000378:metabolism*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism*; D000068103:Serine-Arginine Splicing Factors; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D000941:Antigens; D009687:Nuclear Proteins; D012333:RNA, Messenger; D012261:Ribonucleoproteins; C499372:SRSF2 protein, mouse; D014157:Transcription Factors; D000068103:Serine-Arginine Splicing Factors; D012319:RNA Polymerase II