title: Crinane alkaloids of the amaryllidaceae with cytotoxic effects in human cervical adenocarcinoma (HeLa) cells.
abstract: The family Amaryllidaceae has a long history of usage in the traditional medicinal practices of the indigenous peoples of South Africa, with three of its species known to be used for cancer treatment. Furthermore, the Amaryllidaceae is widely recognized for its unique alkaloid constituents, several of which exhibit potent and selective cytotoxic activities. In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 microM).
authors.forename: Jerald J
authors.initials: JJ
authors.lastname: Nair
authors.forename: Lucie
authors.initials: L
authors.lastname: Rárová
authors.forename: Miroslav
authors.initials: M
authors.lastname: Strnad
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
authors.forename: Lee
authors.initials: L
authors.lastname: Cheesman
authors.forename: Johannes
authors.initials: J
authors.lastname: van Staden
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D047151:Amaryllidaceae Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D003603:Cytotoxins / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D047151:Amaryllidaceae Alkaloids; D003603:Cytotoxins