title: FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal carcinoma cells.
abstract: In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.
authors.affiliation: Department of oncology, Nan Lou Division, Chinese PLA General Hospital, Beijing, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Nan Lou Division, Chinese PLA General Hospital, Beijing, P. R. China.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Li
authors.affiliation: Tumor Center, Chinese PLA General Hospital, Beijing, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, P. R. China.
authors.forename: Weihao
authors.initials: W
authors.lastname: Chen
authors.affiliation: Beijing Institute for Neuroscience, Capital Medical University, Beijing, P. R. China.
authors.forename: Yutao
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cancer and cell Biology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of oncology, Nan Lou Division, Chinese PLA General Hospital, Beijing, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Chinese PLA General Hospital, Beijing, P. R. China.
authors.forename: Enqiang
authors.initials: E
authors.lastname: Linghu
mesh_terms: D021581:Active Transport, Cell Nucleus; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D009361:Neoplasm Invasiveness; D011401:Promoter Regions, Genetic / Q000235:genetics; D050784:Proto-Oncogene Protein c-ets-1 / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D050784:Proto-Oncogene Protein c-ets-1; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C485514:ZBTB7A protein, human; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1