title: Predictive value of gelsolin for the outcomes of preterm neonates: a pilot study.
abstract: BACKGROUND
  Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.
  
  
  METHODS
  A total of 32 preterm neonates born at 23-32 weeks of gestation were enrolled in the study.
  
  
  RESULTS
  Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (P < 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (P < 0.05).
  
  
  CONCLUSIONS
  Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.
authors.affiliation: Department of Pediatrics, Division of Pediatric Pulmonology Unit, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kose
authors.affiliation: Department of Pediatrics, Division of Pediatric Pulmonology Unit, Erciyes University, Kayseri, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Elmas
authors.affiliation: Department of Microbiology, Erciyes University, Kayseri, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Gokahmetoglu
authors.affiliation: Department of Pediatrics, Division of Neonatology, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet Adnan
authors.initials: MA
authors.lastname: Ozturk
authors.affiliation: Department of Pediatrics, Division of Pediatric Pulmonology Unit, Erciyes University, Kayseri, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Ekinci
authors.affiliation: Department of Biostatistics and Bioinformatics, Erciyes University, Kayseri, Turkey.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Elmali
authors.affiliation: Department of Pediatrics, Division of Neonatology, Erciyes University, Kayseri, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Halis
authors.affiliation: Department of Pediatrics, Division of Neonatology, Erciyes University, Kayseri, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Bastug
mesh_terms: D005260:Female; D018260:Gelsolin / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D010865:Pilot Projects; D011237:Predictive Value of Tests
chemical_list: D018260:Gelsolin
keywords: gelsolin; neonatal outcomes; prematurity