title: In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal.
abstract: Efinaconazole is a novel triazole antifungal drug for the topical treatment of onychomycosis, a nail infection caused mainly by dermatophytes. We assessed the potential of efinaconazole to induce resistance in dermatophytes by continuous exposure of Trichophyton rubrum strains to efinaconazole in vitro (12 passages) and in a guinea pig onychomycosis model (8 weeks). There was no evidence of efinaconazole resistance development in the tested strains under the experimental conditions used.
authors.affiliation: Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan iwata_atsushi@kaken.co.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwata
authors.affiliation: Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
authors.forename: Naomichi
authors.initials: N
authors.lastname: Kumagai
authors.affiliation: Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
authors.forename: Maria
authors.initials: M
authors.lastname: Katafuchi-Nagashima
authors.affiliation: Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Sugiura
authors.affiliation: Dow Pharmaceutical Sciences, Valeant Pharmaceuticals N.A. LLC, Petaluma, California, USA.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Pillai
authors.affiliation: Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tatsumi
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D025141:Drug Resistance, Fungal; D006168:Guinea Pigs; D008826:Microbial Sensitivity Tests; D014009:Onychomycosis / Q000188:drug therapy* / Q000382:microbiology; D014230:Triazoles / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects* / Q000502:physiology
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C431707:efinaconazole