title: Anatomy of β-strands at protein-protein interfaces.
abstract: The development of inhibitors for protein-protein interactions frequently involves the mimicry of secondary structure motifs. While helical protein-protein interactions have been heavily targeted, a similar level of success for the inhibition of β-strand and β-sheet rich interfaces has been elusive. We describe an assessment of the full range of β-strand interfaces whose high-resolution structures are available in the Protein Data Bank. This analysis identifies complexes where a β-stand or β-sheet contributes significantly to binding. The results highlight the molecular recognition complexity in strand-mediated interactions relative to helical interfaces and offer guidelines for the construction of β-strand and β-sheet mimics as ligands for protein receptors. The online data set will potentially serve as an entry-point to new classes of protein-protein interaction inhibitors.
authors.affiliation: Department of Chemistry, New York University , New York, New York 10003, United States.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Watkins
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
mesh_terms: D008958:Models, Molecular; D011485:Protein Binding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins