title: Acute myeloid leukemia concurrent with spinal epidural extramedullary myeloid sarcoma accompanied by a high CD25 expression and the FLT3-ITD mutation.
abstract: Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.
authors.affiliation: Department of Hematology, Chiba University Hospital, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Isshiki
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.forename: Emi
authors.initials: E
authors.lastname: Togasaki
authors.forename: Ryoh
authors.initials: R
authors.lastname: Shimizu
authors.forename: Nagisa
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Yamazaki
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Sugita
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Shokichi
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Shio
authors.initials: S
authors.lastname: Sakai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000378:metabolism; D010264:Paraplegia / Q000209:etiology; D011859:Radiography; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging / Q000473:pathology; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: D053645:Interleukin-2 Receptor alpha Subunit; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3