title: pH-responsive controlled release of epirubicin from Fe@Si-PW hybrid nanoparticles.
abstract: An efficient drug delivery system has been fabricated through an electrostatic interaction between epirubicin and H3PW12O40-functionalized silica encapsulated maghemite nanoparticles. The obtained nanoparticles were characterized for morphology, size distribution, drug loading efficiency, drug content and drug release behavior. Our results indicate that the hybrid nanoparticles possess high adsorption capacity for epirubicin (20.6wt.%) and high drug loading efficiency (82.6%). The drug release is greater in acetate buffer (95.8%) as compared to phosphate buffered saline (47.5%). The pH-responsive release of the hybrid drug carrier and high drug loading efficiency are its advantages as a promising carrier.
authors.affiliation: Faculty of Chemistry, Razi University, Kermanshah 67149, Iran. Electronic address: ezzat_rafiee@yahoo.com.
authors.forename: Ezzat
authors.initials: E
authors.lastname: Rafiee
authors.affiliation: Faculty of Chemistry, Razi University, Kermanshah 67149, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Eavani
mesh_terms: D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D015251:Epirubicin / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D015251:Epirubicin; D012822:Silicon Dioxide
keywords: Controlled release; Drug delivery; Drug loading; Epirubicin; Magnetic nanoparticles; Polyoxometalate