title: [Clinical features of non-alcoholic fatty liver disease in cryptogenic hepatocellular carcinoma].
abstract: OBJECTIVE
  Nonalcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether patients with cryptogenic HCC share clinical features similar to that of NAFLD.
  
  
  METHODS
  Cryptogenic HCC was defined as HCC that occurs in patients with the following conditions: HBsAg(-), anti-HCV(-), and alcohol ingestion of less than 20 g/day. All patients diagnosed with cryptogenic HCC from 2005 to 2012 (cryptogenic HCC group), and all patients diagnosed with HBV associated HCC between 2008 and 2012 (HBV-HCC group) were enrolled in the present study. Clinical features, BMI, lipid profiles, presence of diabetes mellitus, hypertension, and metabolic syndrome were compared between the two groups.
  
  
  RESULTS
  Cryptogenic HCC group was composed of 35 patients (19 males and 16 females) with a mean age of 70 ± 11 years. HBV-HCC group was composed of 406 patients (318 males and 88 females) with a mean age of 56 ± 7 years. Patients in the cryptogenic HCC group were older (p=0.001) and female dominant (p=0.042) than those in the HBV-HCC group. There were no differences in the laboratory test results including lipid profiles and Child-Turcotte-Pugh class between the two groups. Patients in the cryptogenic HCC group had higher prevalence of diabetes (37% vs. 17%, p=0.015), hypertension (49% vs.27%, p=0.051), metabolic syndrome (37% vs. 16%, p=0.001), and higher BMI (25.3 kg/m(2) vs. 24.1 kg/m(2), p=0.042) than those in the HBV- HCC group. The tumor stage was more advanced (stage III and IV) at diagnosis in the cryptogenic HCC group than in the HBV-HCC group (60% vs. 37%, p=0.007).
  
  
  CONCLUSIONS
  Cryptogenic HCC has clinical features similar to that of NAFLD and is diagnosed at a more advanced tumor stage.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 405-760, Korea.
authors.forename: Min Young
authors.initials: MY
authors.lastname: Rim
authors.forename: Oh Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Minsu
authors.initials: M
authors.lastname: Ha
authors.forename: Ju Seung
authors.initials: JS
authors.lastname: Kim
authors.forename: Kwang Il
authors.initials: KI
authors.lastname: Ko
authors.forename: Dong Kyu
authors.initials: DK
authors.lastname: Kim
authors.forename: Pil Kyu
authors.initials: PK
authors.lastname: Jang
authors.forename: Jung Yoon
authors.initials: JY
authors.lastname: Han
authors.forename: Pyung Hwa
authors.initials: PH
authors.lastname: Park
authors.forename: Young Kul
authors.initials: YK
authors.lastname: Jung
authors.forename: Duck Joo
authors.initials: DJ
authors.lastname: Choi
authors.forename: Yun Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000473:pathology; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D008055:Lipids / Q000097:blood; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D009367:Neoplasm Staging; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis* / Q000473:pathology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D008055:Lipids