title: [Effect of 6-month therapy with perindopril A on structural-functional state of arterial vascular bed in patients with chronic heart failure].
abstract: In patients with chronic heart failure (CHF) endothelial dysfunction of large vessels is an independent predictor of repeated hospitalizations because of CHF aggravation and cardiac death.
  
  
  OBJECTIVE
  To evaluate the effect of perindopril A (5-10 mg/day) on endothelial function of large vessels in patients with CHF.
  
  
  METHODS
  The study included 30 patients with NYHA class II-III CHF aged 45-70 years. Patients took perindopril A 5-10 mg for 6 months. Patients underwent 24-h BP monitoring, assessment of endothelium vasodilation.
  
  
  RESULTS
  In the end of period of treatment hypotensive effect and improvement of endothelial function of large vessels were achieved. We observed increase of flow-mediated vasodilation (FMD) measured by high-frequency ultrasound of brachial artery after reactive hyperemia: FMD1 4.25 (3.9; 4.8) vs FMD2 6.8 (5.1; 7.4), p = 0.003) and enhancement of pulse wave amplitude estimated by photoplethysmography (shear phase - SF): SF1 6.62 (2.4; 8.7) vs SF2 7.36 (3.8; 10.2) (p = 0.003).
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Belenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Privalova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Danilogorskaia
authors.forename: E F
authors.initials: EF
authors.lastname: Zheleznykh
authors.forename: A A
authors.initials: AA
authors.lastname: Shchendrygina
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001916:Brachial Artery / Q000187:drug effects / Q000503:physiopathology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000627:therapeutic use*; D014664:Vasodilation
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril