title: Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice.
abstract: The nuclear hormone receptors liver X receptor α (LXRα) and peroxisome proliferator-activated receptor γ (PPARγ) play key roles in the development of fatty liver. To determine the link between hepatic PPARγ and LXRα signaling and the development of fatty liver, a LXRα-specific ligand, T0901317, was administered to normal OB/OB and genetically obese (ob/ob) mice lacking hepatic PPARγ (Pparγ(ΔH)). In ob/ob-Pparγ(ΔH) and OB/OB-Pparγ(ΔH) mice, as well as ob/ob-Pparγ(WT) and OB/OB-Pparγ(WT) mice, the liver weights and hepatic triglyceride levels were markedly increased in response to T0901317 treatment. These results suggest that hepatic PPARγ and LXRα signals independently contribute to the development of fatty liver.
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: matsusuk@fukuoka-u.ac.jp.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Matsusue
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aibara
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Hayafuchi
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Matsuo
authors.affiliation: Institute for Clinical Research, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Takiguchi
authors.affiliation: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Gonzalez
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamano
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001786:Blood Glucose; D005234:Fatty Liver / Q000378:metabolism*; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D050155:Lipogenesis; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D000071518:Liver X Receptors; D051379:Mice; D018345:Mice, Knockout; D008820:Mice, Obese; D057093:Orphan Nuclear Receptors / Q000819:agonists / Q000502:physiology*; D047495:PPAR gamma / Q000502:physiology*; D013449:Sulfonamides / Q000494:pharmacology; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
chemical_list: D000924:Anticholesteremic Agents; D001786:Blood Glucose; D006845:Hydrocarbons, Fluorinated; D007004:Hypoglycemic Agents; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047495:PPAR gamma; D013449:Sulfonamides; C000605214:Nr1h3 protein, mouse; C423915:T0901317; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
keywords: Fatty liver; Liver X receptor α; Peroxisome proliferator-activated receptor γ