title: Influence of stromal-epithelial interactions on androgen action.
abstract: Androgen receptor (AR) signaling is vital to the development and function of the prostate and is a key pathway in prostate cancer. AR is differentially expressed in the stroma and epithelium, with both paracrine and autocrine control throughout the prostate. Stromal-epithelial interactions within the prostate are commonly dependent on AR signaling and expression. Alterations in these pathways can promote tumorigenesis. AR is also expressed in normal and malignant mammary tissues. Emerging data indicate a role for AR in certain subtypes of breast cancer that has the potential to be exploited therapeutically. The aim of this review is to highlight the importance of these interactions in normal development and tumorigenesis, with a focus on the prostate and breast.
authors.affiliation: Department of PharmacologyUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Cera M
authors.initials: CM
authors.lastname: Nieto
authors.affiliation: Department of PharmacologyUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Leah C
authors.initials: LC
authors.lastname: Rider
authors.affiliation: Department of PharmacologyUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA Scott.Cramer@ucdenver.edu.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Cramer
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001940:Breast / Q000254:growth & development / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000378:metabolism; D011467:Prostate / Q000254:growth & development / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: D000728:Androgens; D011944:Receptors, Androgen
keywords: androgen receptor; androgens; breast; prostate