title: At the right distance: ER-mitochondria juxtaposition in cell life and death.
abstract: The interface between mitochondria and the endoplasmic reticulum is emerging as a crucial hub for calcium signalling, apoptosis, autophagy and lipid biosynthesis, with far reaching implications in cell life and death and in the regulation of mitochondrial and endoplasmic reticulum function. Here we review our current knowledge on the structural and functional aspects of this interorganellar juxtaposition. This article is part of a Special Issue entitled: Calcium Signaling In Health and Disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.
authors.affiliation: Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padua, Italy.
authors.forename: Deborah
authors.initials: D
authors.lastname: Naon
authors.affiliation: Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padua, Italy. Electronic address: luca.scorrano@unipd.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Scorrano
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D020013:Calcium Signaling; D002451:Cell Compartmentation; D002470:Cell Survival; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D015870:Gene Expression; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism* / Q000648:ultrastructure; D008055:Lipids / Q000096:biosynthesis; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D008055:Lipids; D033681:Mitochondrial Membrane Transport Proteins
keywords: Apoptosis; Ca(2+) signalling; Endoplasmic reticulum; Mitochondria; Mitofusin; Tethering