title: Ten cases of resected solitary pulmonary metastases arising from gastric cancer.
abstract: BACKGROUND
  Because carcinomatous lymphangitis and carcinomatous pleuritis are the usual forms of metastasis associated with gastric cancer, resection of solitary pulmonary metastases arising from gastric cancer is rarely performed. To clarify the characteristics of pulmonary metastases from gastric cancer, we investigated patients who underwent resection of metastatic solitary lung tumors arising from gastric cancer.
  
  
  METHODS
  Between October 2003 and October 2012, 10 patients underwent pulmonary metastasectomy for metastatic gastric cancer at our institution. We retrospectively evaluated features of the primary gastric cancer and the clinicopathological features of the pulmonary metastases in these cases.
  
  
  RESULTS
  70% of the patients had stage II disease. Lymphatic invasion was observed in all cases of primary gastric cancer. The method of pulmonary resection was partial resection in 5 cases, segmentectomy in 1, and lobectomy in 4. On histopathological examination, immunohistochemical staining was negative for thyroid transcription factor-1 and napsin A in all cases. Patients who underwent resection of pulmonary metastases arising from gastric cancer had a good prognosis: the 4-year survival rate was 75%.
  
  
  CONCLUSIONS
  Carefully chosen patients have a good opportunity to obtain benefits from resection of pulmonary metastases arising from gastric cancer.
authors.affiliation: Department of Thoracic, Endocrine and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan yoshidaymac@me.com.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of Thoracic Surgery, Imakiire General Hospital, Kagoshima, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Imakiire
authors.affiliation: Department of Thoracic Surgery, Imakiire General Hospital, Kagoshima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoneda
authors.affiliation: Department of Thoracic Surgery, St. Mary's Hospital, Kurume, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Obuchi
authors.affiliation: Department of Surgery, Fukuoka Tokushukai Hospital, Fukuoka, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inada
authors.affiliation: Department of Thoracic, Endocrine and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D016282:Aspartic Acid Endopeptidases / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000737:chemistry / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D059146:Metastasectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis; D011013:Pneumonectomy / Q000009:adverse effects / Q000401:mortality; D012189:Retrospective Studies; D003074:Solitary Pulmonary Nodule / Q000737:chemistry / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D000074482:Thyroid Nuclear Factor 1; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D016282:Aspartic Acid Endopeptidases; C498549:NAPSA protein, human
keywords: Lung neoplasms; lymphatic metastasis; pneumonectomy; prognosis; stomach neoplasms