title: The prognostic value of the Na⁺/ H⁺ exchanger regulatory factor 1 (NHERF1) protein in cancer.
abstract: NHERF1 (Na⁺/H⁺ exchanger regulatory factor) is a scaffolding protein, consists of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region. NHERF1 recruits macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues. It is involved in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors. Further, NHERF1 also linked other molecules involved in cell growth and cancer progression, such as PDGFR, PTEN, β-catenin, EGFR and HER2/neu. In this review, we focus on the role of NHERF1 during cancer development. Evidences of its involvement in cancer development are present in hepatocellular carcinoma, schwannoma, glioblastoma, colorectal cancer and particularly in breast cancer. Recent findings obtained from our laboratory show that cytoplasmic NHERF1 expression increases gradually in breast cancer during carcinogenesis, and its overexpression is associated with aggressive clinical parameters, unfavourable prognosis, and increased tumor hypoxia. Interestingly, also nuclear NHERF1 expression seems to play a role both in carcinogenesis and progression of colorectal cancer. These data suggest that NHERF1 could be a new biomarker of advanced malignancies.
authors.affiliation: Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Bari, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Saponaro
authors.affiliation: Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Bari, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Malfettone
authors.affiliation: Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Bari, Italy.
authors.forename: Teresa Stefania
authors.initials: TS
authors.lastname: Dell'Endice
authors.affiliation: Scientific Direction, National Cancer Research Centre, Istituto Tumori" Giovanni Paolo II", Bari, Italy.
authors.forename: Anna Elisabetta
authors.initials: AE
authors.lastname: Brunetti
authors.affiliation: Department of Surgical Oncology The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania Department of Surgical Oncology and Gynecological Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Patriciu
authors.initials: P
authors.lastname: Achimas-Cadariu
authors.affiliation: Scientific Direction, National Cancer Research Centre, Istituto Tumori" Giovanni Paolo II", Bari, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Paradiso
authors.affiliation: Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", Bari, Italy.
authors.forename: Anita
authors.initials: A
authors.lastname: Mangia
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D010750:Phosphoproteins / Q000378:metabolism*; D011379:Prognosis; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D010750:Phosphoproteins; D017923:Sodium-Hydrogen Exchangers; C093376:sodium-hydrogen exchanger regulatory factor
keywords: NHERF1; cancer progression; cancers; carcinogenesis