title: Aging of cell membranes: facts and theories.
abstract: This chapter is intended to outline the main results of a research trend realized by the author during the last 45 years, focused on the main role played by the cell membrane in the aging process. It is a very wide field; therefore, the reader cannot expect in this limited space a detailed description, but will be given a wide, interdisciplinary insight into the main facts and theories regarding cellular aging. The central idea described here is the concept called the membrane hypothesis of aging (MHA). The history, the chemical roots, physicochemical facts, biophysical processes, as well as the obligatory biochemical consequences are all touched in by indicating the most important sources of detailed knowledge for those who are more interested in the basic biology of the aging process. This chapter covers also the available anti-aging interventions on the cell membrane by means of the centrophenoxine treatment based on the MHA. It also briefly interprets the possibilities of a just developing anti-aging method by using the recombinant human growth hormone, essential basis of which is the species specificity, and the general presence of receptors of this hormone in the plasma membrane of all types of cells.
authors.affiliation: Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Zs-Nagy
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D004573:Electrolytes / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D019382:Human Growth Hormone / Q000172:deficiency / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology; D017136:Ion Transport / Q000502:physiology; D002504:Meclofenoxate / Q000494:pharmacology; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D018696:Neuroprotective Agents / Q000494:pharmacology; D009857:Oncogenes / Q000502:physiology
chemical_list: D004573:Electrolytes; D016166:Free Radical Scavengers; D005609:Free Radicals; D008565:Membrane Proteins; D018696:Neuroprotective Agents; D019382:Human Growth Hormone; D002504:Meclofenoxate