title: A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal.
abstract: A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4]arene cavity, has been synthesized. The complexation behaviour of receptor L was studied by means of fluorescence spectra and (1)H NMR titration experiments in the presence of K(+) ions and a variety of other anions. The results suggested that receptor L can complex efficiently via the urea cavity or the crown ether moiety, and a positive/negative allosteric effect operating in receptor L was observed.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjo-machi 1, Saga 840-8502, Japan. yamatot@cc.saga-u.ac.jp.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Tomiyasu
authors.forename: Cheng-Cheng
authors.initials: CC
authors.lastname: Jin
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Ni
authors.forename: Xi
authors.initials: X
authors.lastname: Zeng
authors.forename: Carl
authors.initials: C
authors.lastname: Redshaw
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamato