title: General route for preparing β-nitrocarbonyl compounds using copper thermal redox catalysis.
abstract: Using a simple copper catalyst, the alkylation of nitroalkanes with α-bromocarbonyls is now possible. This method provides a general, functional group tolerant route to β-nitrocarbonyl compounds, including nitro amides, esters, ketones, and aldehydes. The highly sterically dense, functional group rich products from these reactions can be readily elaborated into a range of complex nitrogen-containing molecules, including highly substituted β-amino acids.
authors.affiliation: Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
authors.forename: Amber A S
authors.initials: AA
authors.lastname: Gietter
authors.forename: Peter G
authors.initials: PG
authors.lastname: Gildner
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Cinderella
authors.forename: Donald A
authors.initials: DA
authors.lastname: Watson
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004952:Esters; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004952:Esters; D007659:Ketones; D009574:Nitro Compounds; D003300:Copper