title: High prevalence of Ancylostoma ceylanicum hookworm infections in humans, Cambodia, 2012.
abstract: Ancylostoma ceylanicum, a hookworm of canids and felids in Asia, is becoming the second most common hookworm infecting humans. In 2012, we investigated the prevalence and infection dynamics of and risk factors for hookworm infections in humans and dogs in a rural Cambodian village. Over 57% of the population was infected with hookworms; of those, 52% harbored A. ceylanicum hookworms. The greatest intensities of A. ceylanicum eggs were in persons 21-30 years of age. Over 90% of dogs also harbored A. ceylanicum hookworms. Characterization of the cytochrome oxidase-1 gene divided isolates of A. ceylanicum hookworms into 2 groups, 1 containing isolates from humans only and the other a mix of isolates from humans and animals. We hypothesize that preventative chemotherapy in the absence of concurrent hygiene and animal health programs may be a factor leading to emergence of A. ceylanicum infections; thus, we advocate for a One Health approach to control this zoonosis.
authors.forename: Tawin
authors.initials: T
authors.lastname: Inpankaew
authors.forename: Fabian
authors.initials: F
authors.lastname: Schär
authors.forename: Anders
authors.initials: A
authors.lastname: Dalsgaard
authors.forename: Virak
authors.initials: V
authors.lastname: Khieu
authors.forename: Wissanuwat
authors.initials: W
authors.lastname: Chimnoi
authors.forename: Chamnan
authors.initials: C
authors.lastname: Chhoun
authors.forename: Daream
authors.initials: D
authors.lastname: Sok
authors.forename: Hanspeter
authors.initials: H
authors.lastname: Marti
authors.forename: Sinuon
authors.initials: S
authors.lastname: Muth
authors.forename: Peter
authors.initials: P
authors.lastname: Odermatt
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Traub
mesh_terms: D000293:Adolescent; D000328:Adult; D000722:Ancylostoma / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D000724:Ancylostomiasis / Q000453:epidemiology / Q000469:parasitology / Q000635:transmission / Q000662:veterinary*; D000818:Animals; D002160:Cambodia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004283:Dog Diseases / Q000453:epidemiology* / Q000469:parasitology / Q000635:transmission; D004285:Dogs; D003576:Electron Transport Complex IV / Q000235:genetics*; D005243:Feces / Q000469:parasitology; D005260:Female; D015801:Helminth Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D015995:Prevalence; D012424:Rural Population; D015047:Zoonoses
chemical_list: D015801:Helminth Proteins; D003576:Electron Transport Complex IV
keywords: Ancylostoma ceylanicum; Cambodia; hookworm; humans; zoonosis