title: Planning your every move: the role of β-actin and its post-transcriptional regulation in cell motility.
abstract: Cell motility is a tightly regulated process that involves the polymerization of actin subunits. The formation of actin filaments is controlled through a variety of protein factors that accelerate or perturb the polymerization process. As is the case for most biological events, cell movement is also controlled at the level of gene expression. Growing research explains how the β-actin isoform of actin is particularly regulated through post-transcriptional events. This includes the discovery of multiple sites in the 3' untranslated region of β-actin mRNA to which RNA-binding proteins can associate. The control such proteins have on β-actin expression, and as a result, cell migration, continues to develop, and presents a thorough process that involves guiding an mRNA out of the nucleus, to a specific cytosolic destination, and then controlling the translation and decay of this message. In this review we will provide an overview on the recent progress regarding the mechanisms by which actin polymerization modulates cell movement and invasion and we will discuss the importance of post-transcriptional regulatory events in β-actin mediated effects on these processes.
authors.affiliation: McGill University, Biochemistry Department and Rosalind and Morris Goodman Cancer Center, Montreal, Canada.
authors.forename: Lise
authors.initials: L
authors.lastname: Artman
authors.affiliation: Laboratoire de diagnostic moléculaire, CHU Sainte-Justine, Montreal, Canada.
authors.forename: Virginie
authors.initials: V
authors.lastname: Dormoy-Raclet
authors.affiliation: John Abbott College, Biology Department, Sainte-Anne-de-Bellevue, Canada. Electronic address: christopher.vonroretz@johnabbott.qc.ca.
authors.forename: Christopher
authors.initials: C
authors.lastname: von Roretz
authors.affiliation: McGill University, Biochemistry Department and Rosalind and Morris Goodman Cancer Center, Montreal, Canada. Electronic address: imed.gallouzi@mcgill.ca.
authors.forename: Imed-Eddine
authors.initials: IE
authors.lastname: Gallouzi
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002465:Cell Movement; D005786:Gene Expression Regulation; D006801:Humans; D026723:Polyadenylation; D014176:Protein Biosynthesis; D055503:Protein Multimerization; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000199:Actins; D012333:RNA, Messenger
keywords: Actin binding protein; Cell motility; Post-transcriptional regulation; Untranslated region (UTR); Zipcode; β-Actin