title: [Familial adenomatous polyposis:a report of 10 cases in 3 generations of a family and literature review].
abstract: OBJECTIVE
  To investigate the clinical characteristic, diagnosis and treatment of familial adenomatous polyposis (FAP).
  
  
  METHODS
  According to family history of the proband, we surveyed the pedigree and retrospectively analyzed the clinical characteristics of 10 FAP patients in 3 generations of the family.
  
  
  RESULTS
  Among all 10 cases, 3 died of colorectal cancer including two of whom had history of intestinal obstruction.Seven people of the third generation were all diagnosed as FAP. Among them, only 2 patients had clinical symptoms. Colonoscopy was done in all 7 patients before 35 years old. However, none of them had polyps or evidence of cancer.Surgical operation was performed on 1 patient and high frequency electric cutting under endoscopy was performed on 6 patients.
  
  
  CONCLUSIONS
  The early clinical manifestations of FAP are nonspecific. Pedigree investigation and colonoscopy screening for high-risk population are important to find early asymptomatic FAP patients.
authors.forename: Yi
authors.initials: Y
authors.lastname: Nie
authors.forename: Ronggui
authors.initials: R
authors.lastname: Zhang
authors.forename: Kaichun
authors.initials: K
authors.lastname: Fan
authors.affiliation: Department of Gastroenterology, General Hospital of PLA,Beijing 100853, China. Email: lianghao301@163.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Liang
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000328:Adult; D003110:Colonic Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012189:Retrospective Studies; D055815:Young Adult