title: Chiral metal-organic framework used as stationary phases for capillary electrochromatography.
abstract: Metal-organic frameworks (MOFs) have received great attention as novel media in separation sciences because of their fascinating structures and unusual properties. However, to the best of our knowledge, there has been no attempt to utilize chiral MOFs as stationary phases in capillary electrochromatography (CEC). In this study, a homochiral helical MOF [Zn2(D-Cam)2(4,4'-bpy)]n (D-Cam=D-(+)-camphoric acid, 4,4'-bpy=4,4'-bipyridine) was explored as the chiral stationary phase in open tubular capillary electrochromatography (OT-CEC) for separation of chiral compounds and isomers. The MOFs coated column has been developed using a simple procedure via MOFs post-coated on the sodium silicate layer. The baseline separations of flavanone and praziquantel were achieved on the MOFs coated column with high resolution of more than 2.10. The influences of pH, organic modifier content and buffer concentration on separation were investigated. Besides, the separations of isomers (nitrophenols and ionones) were evaluated. The relative standard deviations (RSDs) for the retention time of run-to-run, day-to-day and column-to-column were 1.04%, 2.16% and 3.07%, respectively. The results demonstrated that chiral MOFs are promising for enantioseparation in CEC.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Fei
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200241, PR China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200241, PR China.
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China; Department of Chemistry, East China Normal University, Shanghai 200241, PR China. Electronic address: yuan_limingpd@aliyun.com.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Yuan
mesh_terms: D053801:Capillary Electrochromatography; D015394:Molecular Structure; D009596:Nitrophenols / Q000302:isolation & purification*; D045792:Norisoprenoids / Q000302:isolation & purification*; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D009596:Nitrophenols; D045792:Norisoprenoids; D009942:Organometallic Compounds
keywords: Chiral separation; Metal–organic framework; Open tubular capillary electrochromatography; Stationary phase