title: High-efficiency combinatorial approach as an effective tool for accelerating metallic biomaterials research and discovery.
abstract: A high-efficiency combinatorial approach has been applied to rapidly build the database of composition-dependent elastic modulus and hardness of the Ti-Ta and Ti-Zr-Ta systems. A diffusion multiple of the Ti-Zr-Ta system was manufactured, then annealed at 1173K for 1800h, and water quenched to room temperature. Extensive interdiffusion among Ti, Zr and Ta has taken place. Combining nanoindentation and electron probe micro-analysis (EPMA), the elastic modulus, hardness as well as composition across the diffusion multiple were determined. The composition/elastic modulus/hardness relationship of the Ti-Ta and Ti-Zr-Ta alloys has been obtained. It was found that the elastic modulus and hardness depend strongly on the Ta and Zr content. The result can be used to accelerate the discovery/development of bio-titanium alloys for different components in implant prosthesis.
authors.affiliation: School of Material Science and Engineering, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: X D
authors.initials: XD
authors.lastname: Zhang
authors.affiliation: School of Material Science and Engineering, Central South University, Changsha, Hunan, 410083, PR China; State Key Laboratory for Powder Metallurgy, Changsha, Hunan, 410083, PR China. Electronic address: lbliu.csu@gmail.com.
authors.forename: L B
authors.initials: LB
authors.lastname: Liu
authors.affiliation: State Key Laboratory for Powder Metallurgy, Changsha, Hunan, 410083, PR China; Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH 43210, USA.
authors.forename: J-C
authors.initials: JC
authors.lastname: Zhao
authors.affiliation: School of Material Science and Engineering, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.affiliation: School of Material Science and Engineering, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: F
authors.initials: F
authors.lastname: Zheng
authors.affiliation: School of Material Science and Engineering, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: Z P
authors.initials: ZP
authors.lastname: Jin
mesh_terms: D000497:Alloys / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055119:Elastic Modulus; D004577:Electron Probe Microanalysis / Q000379:methods; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014025:Titanium
keywords: Combinatorial approach; Diffusion multiple; EPMA; Metallic biomaterials; Nanoindentation