title: Impact of MCP-1 in atherosclerosis.
abstract: Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. The expression level is upregulated after proinflammatory stimuli and tissue injury which are associated with atherosclerotic lesion. Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
authors.forename: Vijay
authors.initials: V
authors.lastname: Kakkar
authors.affiliation: The Mary and Garry Weston Molecular Immunology Laboratory, Thrombosis Research Institute, London, SW3 6LR, United Kingdom. xlu@tri-london.ac.uk.
authors.forename: Xinjie
authors.initials: X
authors.lastname: Lu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000473:pathology*; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D018932:Chemokine CCL2; D008074:Lipoproteins