title: Nuclear myocardial perfusion imaging with a cadmium-telluride semiconductor detector gamma camera in patients with acute myocardial infarction.
abstract: OBJECTIVE
  Since myocardial perfusion imaging (MPI) with conventional sodium iodine (NaI) device has low spatial resolution, there have been some cases in which small structures such as non-transmural myocardial infarction could not be properly detected. The purpose of this study was to evaluate potential usefulness of cadmium-telluride (CdTe) semiconductor detector-based high spatial resolution gamma cameras in detecting myocardial infarction sites, especially non-transmural infarction.
  
  
  METHODS
  A total of 38 patients (mean age ± SD: 64 ± 21 year) who were clinically diagnosed with acute myocardial infarction were included. Twenty-eight cases of them were with ST segment elevation myocardial infarction (STEMI) and 10 cases with non-ST segment elevation myocardial infarction (NSTEMI). In all patients, myocardial perfusion single photon emission computed tomography images were acquired with Infinia (NaI device) and R1-M (CdTe device), and the images were compared concerning the detectability of acute myocardial infarction sites.
  
  
  RESULTS
  The detection rates of the myocardial infarction site in cases with STEMI were 100% both by NaI and CdTe images. In cases with NSTEMI, detection rate by NaI images was 50%, while that of CdTe images was 100% (p = 0.033). The summed rest score (SRS) value derived from CdTe images was significantly higher than that from NaI images in cases with STEMI [NaI images: 12 (7-18) versus CdTe images: 14 (9-20)] (p < 0.001). SRS derived from CdTe images was significantly higher than that derived from NaI images in cases with NSTEMI [NaI images: 2 (0-5) versus CdTe images: 6 (6-8)] (p = 0.006).
  
  
  CONCLUSIONS
  These results indicate that MPI using CdTe-semiconductor device will provide a much more accurate assessment of acute myocardial infarction in comparison to current methods.
authors.affiliation: Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ward, Tokyo, 113-8603, Japan, fuku@nms.ac.jp.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Fukushima
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Kumita
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Maruyama
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shinkai
mesh_terms: D000208:Acute Disease; D000368:Aged; D019187:Cadmium Compounds; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D055414:Myocardial Perfusion Imaging / Q000295:instrumentation*; D019047:Phantoms, Imaging; D012666:Semiconductors; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride