title: Effectiveness of an absorbable fibrin sealant patch to reduce lymphoceles formation after axillary lymphadenectomy for breast cancer: a matched-pair analysis.
abstract: BACKGROUND
  This study evaluated the use of TachoSil as an adjunctive therapy for reducing axillary lymphocele formation.
  
  
  METHODS
  Eighty-six patients diagnosed with breast cancer N+ and treated with axillary lymphadenectomy received a TachoSil patch in the axillary wound. Using a database of patients without placing a hemostatic patch, we applied a matched case-control in a 1-to-2 fashion. Multiple and logistic regression analyses were used to evaluate postoperative results.
  
  
  RESULTS
  Patient group with TachoSil showed a significantly lower drainage volume (P < .001) and the length of stay was significantly shorter (P < .001). The number of patients with evacuative punctures was 24.5% in the group with patch versus 51.2% in the control group (P < .001). In multivariate analysis, the use of TachoSil was a significant predictor of reducing axillary drainage volume (P < .001), mean length of hospital stay (P = .001), and number of evacuative punctures of lymphocele (odds ratio .264, 95% confidence interval .144 to .484, P < .001).
  
  
  CONCLUSIONS
  The use of TachoSil in axillary lymphadenectomy may be a safe and useful treatment option for reducing axillary drainage volume, incidence of symptomatic lymphocele, and hospital stay.
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain. Electronic address: helenanr1@hotmail.com.
authors.forename: Elena
authors.initials: E
authors.lastname: Navarro-Rodríguez
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Gómez-Luque
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Nélida
authors.initials: N
authors.lastname: Díaz-Jiménez
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Rioja-Torres
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Bascuñana-Estudillo
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Ruiz-Rabelo
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Ciria-Bru
authors.affiliation: Department of Radiodiagnosis, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Álvarez-Benito
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Rufián-Peña
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Briceño-Delgado
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000601:surgery; D018275:Carcinoma, Lobular / Q000601:surgery; D004338:Drug Combinations; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D016015:Logistic Models; D008197:Lymph Node Excision / Q000379:methods*; D008210:Lymphocele / Q000209:etiology / Q000517:prevention & control*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000517:prevention & control*; D013917:Thrombin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin
keywords: Axillary lymphadenectomy; Breast cancer; Fibrin sealant; Lymphocele; TachoSil