title: Galectins and neovascularization in central nervous system tumors.
abstract: Despite advances in diagnosis and treatment, the overall outcomes for patients with brain tumors remain unpredictable. New prognostic markers are still needed to identify high-risk patients for whom the standard treatment has poor outcomes and would thus be well suited for more aggressive therapies. Neovascularization has long been implicated as a salient feature of glioma progression. In fact, high-grade gliomas are among the most vascular of all solid tumors, and vascular proliferation is a pathological hallmark of glioblastomas. Galectins are known to play important roles in cancer biology, including cancer cell migration, tumor immune escape or tumor angiogenesis. Moreover, galectins were reported to be involved in glioma progression. Given the key role of angiogenesis in brain tumors, the expression of galectins in tumor-associated endothelial cells (EC) and the implication of galectins in angiogenesis, the present review will focus on the expression of galectins in ECs of normal brain and brain tumors.
authors.affiliation: Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Nicky
authors.initials: N
authors.lastname: D'Haene
authors.affiliation: Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Calliope
authors.initials: C
authors.lastname: Maris
authors.affiliation: Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium DIAPATH, Center for Microscopy and Molecular Imaging (CMMI), ULB, Gosselies, Belgium.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Rorive
authors.affiliation: DIAPATH, Center for Microscopy and Molecular Imaging (CMMI), ULB, Gosselies, Belgium Laboratory of Image, Signal Processing and Acoustics, Brussels School of Engineering/Ecole polytechnique de Bruxelles, ULB, Brussels, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Decaestecker
authors.affiliation: Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Le Mercier
authors.affiliation: Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium DIAPATH, Center for Microscopy and Molecular Imaging (CMMI), ULB, Gosselies, Belgium isabelle.salmon@erasme.ulb.ac.be.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Salmon
mesh_terms: D001921:Brain / Q000473:pathology; D002465:Cell Movement / Q000235:genetics; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D037161:Galectins / Q000096:biosynthesis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology
chemical_list: D037161:Galectins
keywords: angiogenesis; brain tumors; endothelial cells; galectins; glioma