title: Injectable in situ forming hybrid iron oxide-hyaluronic acid hydrogel for magnetic resonance imaging and drug delivery.
abstract: The development of multimodal in situ cross-linkable hyaluronic acid nanogels hybridized with iron oxide nanoparticles is reported. Utilizing a chemoselective hydrazone coupling reaction, the nanogels are converted to a macroscopic hybrid hydrogel without any additional reagent. Hydrophobic cargos remain encapsulated in the hydrophobic domains of the hybrid hydrogel without leakage. However, hydrogel degradation with hyaluronidase liberates iron oxide nanoparticles. This allows the utilization of imaging agents as tracers of the hydrogel degradation. UV-vis spectrometry and MRI studies reveal that the degradability of the hydrogels correlates with their structure. The hydrogels presented here are very promising theranostic tools for hyaluronidase-mediated delivery of hydrophobic drugs, as well as imaging of hydrogel degradation and tracking of degradation products in vivo.
authors.affiliation: Science for Life Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångström Uppsala University, Uppsala, 75121, Sweden.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
authors.forename: Dmitri A
authors.initials: DA
authors.lastname: Ossipov
mesh_terms: D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000737:chemistry / Q000494:pharmacology; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D020100:Hydrogels; C000499:ferric oxide; D006820:Hyaluronic Acid
keywords: hyaluronan hydrogels; hybrid organic-inorganic nanogels; in situ cross-linking; iron oxide nanoparticles; magnetic resonance imaging