title: Hypervalent iodine-promoted α-fluorination of acetophenone derivatives with a triethylamine·HF complex.
abstract: The direct fluorination reaction of acetophenone using iodosylarenes and TEA·5HF was conducted under mild conditions except for use of a HF reagent. The fluorination reaction was applied to acetophenone derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone, butyrophenone, 1-indanone, and phenacyl chloride, giving selectively the corresponding α-fluoroketone derivatives in good yields.
authors.affiliation: Department of Chemistry and Applied Chemistry, Graduate School of Science and Engineering, Saga University , Honjo-machi, Saga 840-8502, Japan.
authors.forename: Tsugio
authors.initials: T
authors.lastname: Kitamura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Muta
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Muta
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry; D005021:Ethylamines / Q000737:chemistry*; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000098:Acetophenones; D005021:Ethylamines; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007455:Iodine; C038699:acetophenone; C016162:triethylamine