title: NOD-like receptors in intestinal homeostasis and epithelial tissue repair.
abstract: The intestinal epithelium constitutes a dynamic physical barrier segregating the luminal content from the underlying mucosal tissue. Following injury, the epithelial integrity is restored by rapid migration of intestinal epithelial cells (IECs) across the denuded area in a process known as wound healing. Hence, through a sequence of events involving restitution, proliferation and differentiation of IECs the gap is resealed and homeostasis reestablished. Relapsing damage followed by healing of the inflamed mucosa is a hallmark of several intestinal disorders including inflammatory bowel diseases (IBD). While several regulatory peptides, growth factors and cytokines stimulate restitution of the epithelial layer after injury, recent evidence in the field underscores the contribution of innate immunity in controlling this process. In particular, nucleotide-binding and oligomerization domain-like receptors (NLRs) play critical roles in sensing the commensal microbiota, maintaining homeostasis, and regulating intestinal inflammation. Here, we review the process of intestinal epithelial tissue repair and we specifically focus on the impact of NLR-mediated signaling mechanisms involved in governing epithelial wound healing during disease.
authors.affiliation: Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. marianna.parlato@mssm.edu.
authors.forename: Marianna
authors.initials: M
authors.lastname: Parlato
authors.affiliation: Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. garabet.yeretssian@mssm.edu.
authors.forename: Garabet
authors.initials: G
authors.lastname: Yeretssian
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000032:analysis / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology*; D053472:Nod Signaling Adaptor Proteins / Q000032:analysis / Q000276:immunology*; D051193:Toll-Like Receptors / Q000032:analysis / Q000276:immunology; D014945:Wound Healing
chemical_list: D058847:Inflammasomes; D053472:Nod Signaling Adaptor Proteins; D051193:Toll-Like Receptors