title: Systematic review and meta-analysis of parent and family-based interventions for children and adolescents with chronic medical conditions.
abstract: OBJECTIVE
  To quantify the effects of parent- and family-based psychological therapies for youth with common chronic medical conditions on parent and family outcomes (primary aim) and child outcomes (secondary aim).
  
  
  METHODS
  MEDLINE, EMBASE, and PsycINFO were searched from inception to April 2013. 37 randomized controlled trials were included. Quality of the evidence was evaluated using GRADE criteria. Data were extracted on parent, family, and child outcomes.
  
  
  RESULTS
  Pooled psychological therapies had a positive effect on parent behavior at posttreatment and follow-up; no significant improvement was observed for other outcome domains. Problem-solving therapy (PST) improved parent mental health and parent behavior at posttreatment and follow-up. There was insufficient evidence to evaluate cognitive-behavioral and systems therapies for many outcome domains.
  
  
  CONCLUSIONS
  Parent- and family-based psychological therapies can improve parent outcomes, with PST emerging as particularly promising. Future research should incorporate consensus statements for outcomes assessment, multisite recruitment, and active comparator conditions.
authors.affiliation: Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, and Centre for Pain Research, University of Bath Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, and Centre for Pain Research, University of Bath emily.law@seattlechildrens.org.
authors.forename: Emily F
authors.initials: EF
authors.lastname: Law
authors.affiliation: Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, and Centre for Pain Research, University of Bath.
authors.forename: Emma
authors.initials: E
authors.lastname: Fisher
authors.affiliation: Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, and Centre for Pain Research, University of Bath.
authors.forename: Jessica
authors.initials: J
authors.lastname: Fales
authors.affiliation: Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, and Centre for Pain Research, University of Bath.
authors.forename: Melanie
authors.initials: M
authors.lastname: Noel
authors.affiliation: Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, and Centre for Pain Research, University of Bath.
authors.forename: Christopher
authors.initials: C
authors.lastname: Eccleston
mesh_terms: D000293:Adolescent; D002648:Child; D002908:Chronic Disease / Q000523:psychology / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005196:Family Therapy / Q000379:methods*; D006801:Humans; D010290:Parents / Q000523:psychology*; D016896:Treatment Outcome
keywords: asthma; cancer; cardiovascular disease; children; chronic illness; chronic pain; cystic fibrosis; diabetes mellitus; epilepsy; family; meta-analysis; parent; psychological therapies; randomized controlled trials; solid organ transplant; spina bifida; systematic review; traumatic brain injury