title: Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".
abstract: The inference to stem cells has been found in ancient myths and the concept of stem cells has existed in the fields of plant biology, developmental biology and embryology for decades. In the field of cancer research, the stem cell theory was one of the earliest hypotheses on the origin of a cancer from a single cell. However, an opposing hypothesis had it that an adult differentiated somatic cell could "de-differentiate" to become a cancer cell. Only within the last decade, via the "cloning" of Dolly, the sheep, did the field of stem cell biology really trigger an exciting revolution in biological research. The isolation of human embryonic stem cells has created a true revolution in the life sciences that has led to the hope that these human stem cells could lead to (a) basic science understanding of gene regulation during differentiation and development; (b) stem cell therapy; (c) gene therapy via stem cells; (d) the use of stem cells for drug discovery; (e) screening for toxic effects of chemicals; and (f) understand the aging and diseases of aging processes.
authors.affiliation: Department of Pediatrics/Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Trosko
keywords: Adult stem cells; De-differentiation theory; Initiation/promotion/progression hypothesis of carcinogenesis; Oct-4; Re-programming; Stem cell theory of carcinogenesis; iPS cells