title: Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study.
abstract: BACKGROUND
  Certain markers have been identified over the last 10 years that facilitate the prediction of a patient's prognosis; these markers have been proposed to be useful for risk stratification of lymphoma patients and for the development of specific therapeutic strategies. In the present study, we assessed the potential prognostic value of SPRR1A expression in 967 patients with diffuse large B-cell lymphomas.
  
  
  METHODS
  All patients were enrolled between 2001 and 2007 (median follow-up, 53.3 months) in the Second Hospital of Dalian Medical University, First Hospital of China Medical University, and Liaoning Cancer Hospital. Immunohistochemical analysis was used to evaluate the expression of SPRR1A. Survival was analyzed using the Kaplan-Meier method. Multivariate analysis was conducted to adjust the effect of SPRR1A expression for potential, well-known, independent prognostic factors.
  
  
  RESULTS
  Of the 967 patients examined, SPRR1A expression was detected in 305 (31.54%) patients on immunohistochemical analysis. The 5-year survival rate was significantly lower in patients with SPRR1A expression than in those without (26.9% vs. 53.2%, P < 0.001). Multivariate analysis identified SPRR1A expression as an independent predictor of survival in addition to lactate dehydrogenase level, clinical stage, and histologic subtype.
  
  
  CONCLUSIONS
  SPRR1A expression may be useful as a prognostic factor for diffuse large B-cell lymphoma.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Jiyue
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Breast Surgery, Second Hospital of Dalian Medical University, Dalian 116023, China. yincailove@126.com.
authors.forename: Zuowei
authors.initials: Z
authors.lastname: Zhao
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.forename: Caigang
authors.initials: C
authors.lastname: Liu
mesh_terms: D000368:Aged; D002681:China; D055233:Cornified Envelope Proline-Rich Proteins / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D055233:Cornified Envelope Proline-Rich Proteins; C524531:SPRR1A protein, human