title: Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with β-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine.
abstract: Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with β-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner. Clinical Trials Registration. NCT01846923.
authors.affiliation: Infectious Diseases Unit, First Department of Paediatrics, Aghia Sofia Children's Hospital.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Papadatou
authors.affiliation: Department of Biological Chemistry, Medical School.
authors.forename: Cristina
authors.initials: C
authors.lastname: Piperi
authors.affiliation: Department of Biological Chemistry, Medical School.
authors.forename: Krystallenia
authors.initials: K
authors.lastname: Alexandraki
authors.affiliation: Thalassemia Unit, Aghia Sofia Children's Hospital, University of Athens, Greece.
authors.forename: Antonis
authors.initials: A
authors.lastname: Kattamis
authors.affiliation: Infectious Diseases Unit, First Department of Paediatrics, Aghia Sofia Children's Hospital.
authors.forename: Maria
authors.initials: M
authors.lastname: Theodoridou
authors.affiliation: Infectious Diseases Unit, First Department of Paediatrics, Aghia Sofia Children's Hospital.
authors.forename: Vana
authors.initials: V
authors.lastname: Spoulou
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007156:Immunologic Memory; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000382:microbiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D065288:Serogroup; D013156:Splenectomy / Q000009:adverse effects; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology*; D014611:Vaccination; D055815:Young Adult; D017086:beta-Thalassemia / Q000150:complications / Q000276:immunology* / Q000601:surgery
chemical_list: C538862:13-valent pneumococcal vaccine; C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000907:Antibodies, Bacterial; D018985:Epitopes, B-Lymphocyte; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D022242:Pneumococcal Vaccines
keywords: immunological hyporesponsiveness; immunological memory; memory B cells; pneumococcal vaccine