title: Measles in pregnancy in Lyon France, 2011.
abstract: OBJECTIVE
  To identify women who had measles while being pregnant during the 2011 epidemic peak in Lyon, France, and to document maternal characteristics and fetal outcomes.
  
  
  METHODS
  In a retrospective survey, women who had measles while being pregnant between January and December 2011 were identified from the records of the Laboratory of Virology, Hospices Civils de Lyon. Epidemiologic data, clinical characteristics, and measles outcomes were assessed.
  
  
  RESULTS
  In total, 11 pregnant women and 2 women who had just delivered were hospitalized with measles infection in Lyon. The most severe maternal complication was pneumonia, which occurred in 4 women (30.8%). Other maternal complications included fever (11 women; 84.6%) and elevated liver enzymes (2/6 women; 33.3%). All women delivered healthy newborns. Post-exposure prophylaxis using human polyvalent immunoglobulin was initiated for three newborns whose mothers acquired measles in the immediate postpartum period. None of these newborns subsequently acquired measles, although breastfeeding was maintained.
  
  
  CONCLUSIONS
  Although measles infections during pregnancy can have a deleterious effect on both mother and child, in many cases hospitalization is not required. Unnecessary admission should be avoided given the high risk of transmission of measles in an obstetrics ward.
authors.affiliation: Laboratory of Virology, Hospices Civils de Lyon, Lyon, France. Electronic address: jean-sebastien.casalegno@chu-lyon.fr.
authors.forename: Jean-Sebastien
authors.initials: JS
authors.lastname: Casalegno
authors.affiliation: Department of Gynecology and Obstetrics, Hospices Civils de Lyon, Lyon, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Huissoud
authors.affiliation: Department of Gynecology and Obstetrics, Hospices Civils de Lyon, Lyon, France.
authors.forename: Rene
authors.initials: R
authors.lastname: Rudigoz
authors.affiliation: Department of Gynecology and Obstetrics, Hospices Civils de Lyon, Lyon, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Massardier
authors.affiliation: Department of Gynecology and Obstetrics, Hospices Civils de Lyon, Lyon, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Gaucherand
authors.affiliation: Laboratory of Virology, Hospices Civils de Lyon, Lyon, France.
authors.forename: Yahia
authors.initials: Y
authors.lastname: Mekki
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D008457:Measles / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D008459:Measles virus / Q000302:isolation & purification; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D011256:Pregnancy Outcome; D011295:Prenatal Care; D012189:Retrospective Studies
keywords: France; Human polyvalent immunoglobulin; Measles; Pneumonia; Pregnancy; Vaccination