title: Maintenance of chromosome structure in Pseudomonas aeruginosa.
abstract: Replication and segregation of genetic information are the activities central to the well-being of all living cells. Concerted mechanisms have evolved that ensure that each cellular chromosome is replicated once and only once per cell cycle and then faithfully segregated into daughter cells. Despite remarkable taxonomic diversity, these mechanisms are largely conserved across eubacteria, although species-specific distinctions can often be noted. Here, we provide an overview of the current state of knowledge about maintenance of the chromosome structure in Pseudomonas aeruginosa. We focus on global chromosome organization and its dynamics during DNA replication and cell division. Special emphasis is made on contrasting these activities in P. aeruginosa and other bacteria. Among unique P. aeruginosa, features are the presence of two distinct autonomously replicating sequences and multiple condensins, which suggests existence of novel regulatory mechanisms.
authors.affiliation: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.
authors.forename: Valentin V
authors.initials: VV
authors.lastname: Rybenkov
mesh_terms: D002455:Cell Division; D020090:Chromosome Segregation; D022004:Chromosome Structures; D004261:DNA Replication; D016680:Genome, Bacterial; D042822:Genomic Instability; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000502:physiology
keywords: MksBEF; PA4685; Pseudomonas aeruginosa; SMC; chromosome structure; condensins