title: The miRNA-mediated cross-talk between transcripts provides a novel layer of posttranscriptional regulation.
abstract: Endogenously expressed transcripts that are posttranscriptionally regulated by the same microRNAs (miRNAs) will, in principle, compete for the binding of their shared small noncoding RNA regulators and modulate each other's abundance. Recently, the levels of some coding as well as noncoding transcripts have indeed been found to be regulated in this way. Transcripts that engage in such regulatory interactions are referred to as competitive endogenous RNAs (ceRNAs). This novel layer of posttranscriptional regulation has been shown to contribute to diverse aspects of organismal and cellular biology, despite the number of functionally characterized ceRNAs being as yet relatively low. Importantly, increasing evidence suggests that the dysregulation of some ceRNA interactions is associated with disease etiology, most preeminently with cancer. Here we review how posttranscriptional regulation by miRNAs contributes to the cross-talk between transcripts and review examples of known ceRNAs by highlighting the features underlying their interactions and what might be their biological relevance.
authors.affiliation: MRC Functional Genomics Unit, University of Oxford, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
authors.forename: Jennifer Y
authors.initials: JY
authors.lastname: Tan
authors.affiliation: MRC Functional Genomics Unit, University of Oxford, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Marques
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics
chemical_list: D035683:MicroRNAs; D012322:RNA Precursors; D062085:RNA, Long Noncoding
keywords: Competitive endogenous RNAs; Posttranscriptional regulation; ceRNAs; miRNA decoys; miRNA sponges; miRNAs; microRNAs