title: [Stearoyl-CoA desaturase--the lipid metabolism regulator].
abstract: Stearoyl-CoA desaturase is an enzyme from the class of oxidoreductase, which catalyzes the formation of a fatty acid double bond between C9 and C10. It plays a key role in composition of the fatty acid profile in adipose tissue and animal products such as meat and milk. Additionally, it is an important regulator of metabolic processes in the body, and it determines the maintenance of energy homeostasis. This enzyme is encoded by an SCD gene, which, depending on the species, may exist as different isoforms. mRNA expression of stearoyl-CoA desaturase is dependent on many factors, including diet, hormones, and the activity of other genes. In previous studies, several mutations were characterized within the sequence of Δ9-desaturase, which may affect the activity of the protein in the tissues, as well as the value of breeding animals. Effects of particular mutations of the gene encoding the enzyme appears to be particularly important for diseases associated with obesity, diabetes, hypertension, heart diseases or cancer in humans. Also, it seems that using sheep as a potential animal model could be helpful in uncovering and understanding the mechanisms regulated by stearoyl-CoA desaturase.
authors.affiliation: Pracownia Biotechnologii i Genomiki, Katedra Hodowli Trzody Chlewnej i Małych Przeżuwaczy, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy w Krakowie.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Kucharski
authors.affiliation: Pracownia Biotechnologii i Genomiki, Katedra Hodowli Trzody Chlewnej i Małych Przeżuwaczy, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy w Krakowie.
authors.forename: Urszula
authors.initials: U
authors.lastname: Kaczor
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D003920:Diabetes Mellitus / Q000201:enzymology; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology; D005227:Fatty Acids / Q000096:biosynthesis*; D006331:Heart Diseases / Q000201:enzymology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000201:enzymology; D050356:Lipid Metabolism / Q000502:physiology*; D008892:Milk; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology; D009765:Obesity / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012756:Sheep; D013230:Stearoyl-CoA Desaturase / Q000235:genetics* / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D012333:RNA, Messenger; C523776:SCD1 protein, human; D013230:Stearoyl-CoA Desaturase