title: Parts, assembly and operation of the RIG-I family of motors.
abstract: Host cell invasion is monitored by a series of pattern recognition receptors (PRRs) that activate the innate immune machinery upon detection of a cognate pathogen associated molecular pattern (PAMP). The RIG-I like receptor (RLR) family of PRRs includes three proteins--RIG-I, MDA5, and LGP2--responsible for the detection of intracellular pathogenic RNA. All RLR proteins are built around an ATPase core homologous to those found in canonical Superfamily 2 (SF2) RNA helicases, which has been modified through the addition of novel accessory domains to recognize duplex RNA. This review focuses on the structural bases for pathogen-specific dsRNA binding and ATPase activation in RLRs, differential RNA recognition by RLR family members, and implications for other duplex RNA activated ATPases, such as Dicer.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, United States.
authors.forename: David C
authors.initials: DC
authors.lastname: Rawling
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, United States; Department of Chemistry, Yale University, New Haven, CT 06520, United States; Howard Hughes Medical Institute, Chevy Chase, MD 20815, United States. Electronic address: anna.pyle@yale.edu.
authors.forename: Anna Marie
authors.initials: AM
authors.lastname: Pyle
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D053487:DEAD-box RNA Helicases / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020409:Molecular Motor Proteins; D012367:RNA, Viral; D000255:Adenosine Triphosphate; D053487:DEAD-box RNA Helicases