title: Incidence and clinical management of oral human papillomavirus infection in men: a series of key short messages.
abstract: Oral human papillomavirus (HPV) infections are less prevalent than genital and anal infections. However, the incidence of oropharyngeal squamous cell carcinomas has increased significantly over the last 2 decades in several countries. At least 90% of these cancers are associated with oncogenic type HPV16. Oral HPV infections are notably more frequent in men than in women, and the incidence of HPV-positive oropharyngeal squamous cell carcinomas has increased, predominantly among mid-adult men. Nevertheless, little is known about the progression of oral HPV infection to cancer, and it remains unclear which medical interventions should be applied to modify the natural history of the disease. This narrative review aimed at non-experts in HPV infection provides an update on oral HPV infection and its clinical management in men. Furthermore, using the cervix as a reference anatomical site, the lessons learned from investigations on cervical HPV infection are also addressed.
authors.affiliation: Lluita Contra La SIDA Foundation, Hospital Universitari Germans Trias i Pujol, 08916 Badalona (Barcelona), Spain.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Videla
authors.forename: Laila
authors.initials: L
authors.lastname: Darwich
authors.forename: MariPaz
authors.initials: M
authors.lastname: Cañadas
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.forename: Guillem
authors.initials: G
authors.lastname: Sirera
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines / Q000627:therapeutic use; D012737:Sex Factors; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D053918:Papillomavirus Vaccines
keywords: clinical management; human papillomavirus; men; oral infection; oropharyngeal squamous cell carcinomas