title: Acute and 4-week repeated-dose oral toxicity studies of Cirsium setidens in rats.
abstract: Cirsium setidens is a wild perennial plant species found in Korea that may have anti-oxidative, anti-adipogenic, and hepatoprotective activities. However, details of the toxicology of C. setidens remain unknown. This study was performed to evaluate the toxicological effects of an acute administration and 4-week repeated dosing of a C. setidens extract in Sprague-Dawley rats to ensure the safe use of this extract. C. setidens (1250, 2500, and 5000 mg/kg body weight/day) did not induce significant toxicological changes in groups matched by gender with respect to mortality, clinical signs, body weight, urinalysis, ophthalmoscopy, necropsy findings, hematology, and histopathology. Therefore, this study demonstrates that acute administration and 4-week repeated dosing of C. setidens extract orally using this administration protocol is safe.
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. jongseoklee78@gmail.com.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. vvkyh@naver.com.
authors.forename: Young-Hyun
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. danbekim22@nate.com.
authors.forename: Dan-Bi
authors.initials: DB
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea. wsbang@ynu.ac.kr.
authors.forename: Woo-Suk
authors.initials: WS
authors.lastname: Bang
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. loh99@kangwon.ac.kr.
authors.forename: Ok-Hwan
authors.initials: OH
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D031180:Cirsium / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts