title: Animal models of C-reactive protein.
abstract: As the main theme of this special issue, CRP not only is an inflammatory marker but also has diverse biological functions associated with different diseases. To investigate CRP's physiologies and their relationship with human pathological significance, it is essential to use appropriate animal models for translational research. The most popular models for the study of CRP are transgenic mice. However, researchers should be careful when extrapolating the findings derived from these animal models. This review will discuss the current concerns on CRP transgenic mice and rabbits.
authors.affiliation: Department of Laboratory Medicine, Robert Bosch Hospital, Auerbach Street 110, 70376 Stuttgart, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Torzewski
authors.affiliation: Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan.
authors.forename: Ahmed Bilal
authors.initials: AB
authors.lastname: Waqar
authors.affiliation: Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan.
authors.forename: Jianglin
authors.initials: J
authors.lastname: Fan
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D011817:Rabbits
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein