title: [UBE2B gene and male infertility: an update].
abstract: Male infertility is a worldwide problem, and about 15% of the cases are associated with spermatogenesis-related gene mutation. The mammalian gene UBE2B is the homolog of the RAD6 gene of yeast, belonging to the ubiquitin proteasome system and playing an important role in spermatogenesis. Mice lacking the UBE2B gene are infertile, with reduced sperm motility, increased morphologically abnormal sperm, and inhibited meiosis of spermatogonia. Accumulated evidence shows that UBE2B gene mutants and single nucleotide polymorphisms are associated with male infertility. This article reviews the relation between the UBE2B gene and male infertility, offering some theoretical evidence for the diagnosis and treatment of male infertility.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Mou
authors.forename: Yao-Ting
authors.initials: YT
authors.lastname: Gui
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Cai
mesh_terms: D000818:Animals; D053627:Asthenozoospermia / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008540:Meiosis; D051379:Mice; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D013091:Spermatogenesis / Q000235:genetics*; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics*
chemical_list: C471546:UBE2B protein, human; C465394:Ube2b protein, mouse; D044763:Ubiquitin-Conjugating Enzymes