title: Two cases of recurrent abortion in which isodicentric chromosome 15 was observed in the husbands.
abstract: We report two cases of women positive for anticardiolipin antibodies who experienced recurrent abortion whose husbands had isodicentric chromosome 15 aberrations who eventually had successful pregnancies. Two women were referred to our hospital due to their medical history of recurrent abortion. Both were diagnosed as being positive for anticardiolipin antibodies and their husbands with isodicentric chromosome 15. After both patients were treated with a Japanese herbal medicine (Sairei-to) and low-dose aspirin for the positive anticardiolipin antibodies, they delivered appropriate-for-date infants at term gestation. Although both husbands were revealed to have isodicentric chromosome 15, and coincidentally both wives were positive for anticardiolipin antibodies, their next pregnancies continued uneventfully as a result of the treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Niigata University General Hospital of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Nonaka
authors.forename: Izumi
authors.initials: I
authors.lastname: Ooki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Enomoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Takakuwa
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D025063:Chromosome Disorders / Q000150:complications; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy
keywords: anticardiolipin antibody; isodicentric 15; recurrent abortion