title: P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: a meta-analysis.
abstract: OBJECTIVE
  The prognoses of seizure treatment with P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs after glioma resection surgery were investigated across several clinical studies. However, the results of these studies are inconsistent. We examined the relevant studies and conducted a meta-analysis of these two types of anti-epileptic drugs.
  
  
  METHODS
  A bibliography search using the EMBASE, MEDLINE, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials databases was performed to identify potentially relevant articles and conference abstracts that investigated the effects of non-enzyme-inducing antiepileptic drugs (NEIAEDs) and enzyme-inducing antiepileptic drugs (EIAEDs) on the seizure prognoses of glioma patients.
  
  
  RESULTS
  One RCT study and five observational studies were included. Pooled estimates of the relative risks (OR) and 95% confidence intervals (CI) were calculated. The pooled odds ratio for NEIAEDs vs. EIAEDs for patients with glioma was 1.12 (95% CI=0.70-2.10). The pooled odds ratio for NEIAEDs vs. EIAEDs for low-grade gliomas was 1.77 (95% CI=0.71-4.40). The pooled odds ratio for LEV vs. PHY was 1.459 (95% CI=0.731-2.910).
  
  
  CONCLUSIONS
  No significant difference between the efficacies of P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for prophylactic late seizure treatment was observed. However, few RCTs were available, and the acquisition of further evidence through high-quality RCTs is highly recommended.
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 76896489@qq.om.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: West China Medical School of Si Chuan University, 610041, China. Electronic address: 297913442@qq.com.
authors.forename: Mao
authors.initials: M
authors.lastname: Yunhe
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 4589235@qq.com.
authors.forename: Wang
authors.initials: W
authors.lastname: Xiang
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 827005432@qq.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Yanhui
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 26250611@qq.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yanwu
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 415195343@qq.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Shuang
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 466230959@qq.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Ruofei
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: 644925826@qq.com.
authors.forename: Luo
authors.initials: L
authors.lastname: Jiewen
authors.affiliation: Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 610041, China. Electronic address: qingmao2000@163.com.
authors.forename: Mao
authors.initials: M
authors.lastname: Qing
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005910:Glioma / Q000150:complications / Q000601:surgery*; D006801:Humans; D064887:Observational Studies as Topic; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000927:Anticonvulsants; D003577:Cytochrome P-450 Enzyme System
keywords: AEDs; Glioma; P450; Treatment