title: Association of single nucleotide polymorphisms of ERCC1 and XPF with colorectal cancer risk and interaction with tobacco use.
abstract: We investigated the association between polymorphisms in excision repair cross-complementation group 1 (ERCC1) (rs3212986, rs2298881 and rs11615) and xeroderma pigmentosum-complementation group F (XPF) (rs2276466 and rs6498486) and risk of colorectal cancer. A 1:1 matched case-control study was conducted. Conditional regression analysis indicated that individuals carrying the ERCC1 rs3212986 TT genotype and T allele had a marginally increased risk of colorectal cancer when compared with subjects with the GG genotype. Similarly, subjects carrying the rs11615 TT genotype and T allele had a marginally increased risk of colorectal cancer when compared with those with the CC genotype. Stratified analysis revealed that individuals with rs3212986 TT who were current or former smokers had a significantly increased risk of colorectal cancer, and a significant interaction was found between this SNP and cigarette smoking. In conclusion, our study suggests that rs3212986 and rs11615 polymorphisms are associated with risk of colorectal cancer in a Chinese population, particularly in smokers. This finding could be useful in revealing the genetic characteristics of colorectal cancer, and suggests more effective strategies for prevention and treatment.
authors.affiliation: Gastrointestinal Department, China-Japan Union Hospital Jilin University, Changchun 130033, China.
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Hou
authors.affiliation: Ultrasonography Department, China-Japan Union Hospital Jilin University, Changchun 130033, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Gastrointestinal Department, China-Japan Union Hospital Jilin University, Changchun 130033, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Gastrointestinal Department, China-Japan Union Hospital Jilin University, Changchun 130033, China.
authors.forename: Libo
authors.initials: L
authors.lastname: Sun
authors.affiliation: Gastrointestinal Department, China-Japan Union Hospital Jilin University, Changchun 130033, China.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Shu
authors.affiliation: Gastrointestinal Department, China-Japan Union Hospital Jilin University, Changchun 130033, China. Electronic address: lifan0689@yeah.net.
authors.forename: Jisheng
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University, Chengdu, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C095888:xeroderma pigmentosum group F protein; C071447:ERCC1 protein, human; D004720:Endonucleases
keywords: Colorectal cancer; ERCC1; Genetic polymorphisms; Risk; XPF