title: Hierarchical porous bioactive glasses/PLGA-magnetic SBA-15 for dual-drug release.
abstract: The hierarchical porous bioglass combined with magnetic SBA-15 was synthesized. The bioactive glass materials possess a hierarchical porous structure with the macroporous (50μm) and the mesoporous (3.86nm) structures derived from the plant template (cattail stem) and triblock polyethylene oxide-propylene oxide block copolymer (P123), respectively. Magnetic SBA-15 was synthesized by adopting the post assembly method using Fe(NO3)3 as iron source and ethylene glycol as reduction. After coating PLGA, PLGA-IBU-magnetic SBA-15 also possessed super-paramagnetism and the corresponding saturation magnetizations (Ms) could reach 2.6emug(-1). Metformin HCl (MH) and ibuprofen (IBU) were used as model drugs, and the drug release kinetics was studied. MH and IBU could release 60% and 85% from the sample respectively. The system shows excellent dual-drug controlled delivery performance and good bioactivity in vitro that leads to good potential application on bone regeneration.
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Bian
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Xiang
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wu
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China. Electronic address: qufengyu2013@gmail.com.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Qu
mesh_terms: D002516:Ceramics / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006860:Hydrogen Bonding; D007052:Ibuprofen / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D008280:Magnetics; D008687:Metformin / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D012822:Silicon Dioxide / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C022107:Bioglass; C509969:SBA-15; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012822:Silicon Dioxide; D008687:Metformin; D017886:Durapatite; D007052:Ibuprofen
keywords: Controlled release; Dual-drug; Hierarchical porous bioglasses; Magnetic SBA-15