title: Tissue factor-fVIIa inhibition: update on an unfinished quest for a novel oral antithrombotic.
abstract: The tissue factor-coagulation factor VIIa complex (TF-fVIIa) is a well-validated biological target and has been the focus of extensive research directed toward the discovery of novel oral antithrombotics. This review briefly summarizes the key antithrombotic target validation data and provides an update on recent advances in small molecule TF-fVIIa inhibitors.
authors.affiliation: Bristol-Myers Squibb Research, 311 Pennington-Rocky-Hill Road, Pennington, NJ 08534, USA. Electronic address: scott.priestley@bms.com.
authors.forename: E Scott
authors.initials: ES
authors.lastname: Priestley
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015195:Drug Design; D015942:Factor VIIa / Q000037:antagonists & inhibitors*; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D013925:Thromboplastin / Q000037:antagonists & inhibitors*
chemical_list: D005343:Fibrinolytic Agents; D013925:Thromboplastin; D015942:Factor VIIa