title: Regional Cerebral Blood-Flow with 99mTc-ECD Brain Perfusion SPECT in Landau-Kleffner Syndrome: Report of Two Cases.
abstract: Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS. A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy. The degree of regional cerebral perfusion impairment did not correlate with the severity of the clinical and EEG abnormalities, but the area of hypoperfusion was compatible with the speech area of the brain. Overall, although asymmetrical temporoparietal perfusion appears as a common finding in LKS, SPECT findings in LKS alone cannot elucidate the pathogenic features of the disorder in the brain. Here, we present two cases of LKS in which we investigated SPECT perfusion scans.
authors.affiliation: Department of Neurology, Bushehr Medical Center Hospital, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Nemati
authors.affiliation: The Persian Gulf Tropical and Infectious Diseases Research Centre, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan 4917765181, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Javadi
authors.affiliation: The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran.
authors.forename: Negar
authors.initials: N
authors.lastname: Chabi
authors.affiliation: The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran.
authors.forename: Majid
authors.identifier: 0000-0002-2166-3765
authors.initials: M
authors.lastname: Assadi