title: Patient-prosthesis mismatch increases the mean platelet volume in patients with aortic valve replacement.
abstract: OBJECTIVE
  Patient-prosthesis mismatch (PPM) is defined when the ratio of the effective orifice area of the normally functioning prosthetic valve to the body surface area of the patient is <0.85 cm(2)/m(2). The aim of this study was to assess the measurements of the mean platelet volume (MPV) as an indicator of platelet activation in patients with PPM.
  
  
  METHODS
  A total of 109 patients with isolated aortic valve replacement (AVR) procedures with a mechanical prosthesis and a control group from a normal population of 102 people compatible in terms of age and sex were chosen for the study. The AVR group was subdivided into a PPM group (n = 41) and non-PPM group (n = 68). All patients and control participants underwent echocardiographic examinations, with simultaneous measurements of the serum MPV values.
  
  
  RESULTS
  The MPV measurements were significantly higher in the patients with AVR compared to the control group (8.97 ± 0.93 vs. 8.26 ± 0.14, p < 0.001). Higher results were also obtained in the patients with PPM compared to the non-PPM group (9.36 ± 0.61 vs. 8.73 ± 1.01, p < 0.001). The platelet counts were found to be similar in both groups (p > 0.05).
  
  
  CONCLUSIONS
  We have herein shown that the PPM patients had a significantly higher MPV compared to the patients with AVR without PPM and healthy subjects.
authors.affiliation: Department of Cardiovascular Surgery, Ataturk Education and Research Hospital, 1426. Cad, No: 30/17, Cukurambar, 06510, Ankara, Turkey, drhuseyinbayram@gmail.com.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bayram
authors.forename: Mete
authors.initials: M
authors.lastname: Hidiroglu
authors.forename: Levent
authors.initials: L
authors.lastname: Cetin
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Cicek
authors.forename: Aslihan
authors.initials: A
authors.lastname: Kucuker
authors.forename: Emrah
authors.initials: E
authors.lastname: Uguz
authors.forename: Kemal Esref
authors.initials: KE
authors.lastname: Erdogan
authors.forename: Erol
authors.initials: E
authors.lastname: Sener
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D001783:Blood Flow Velocity; D004452:Echocardiography; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation; D011474:Prosthesis Design; D011475:Prosthesis Failure / Q000009:adverse effects; D017755:Prosthesis Fitting / Q000009:adverse effects*