title: Dysfunctional Wnt/β-catenin signaling contributes to blood-brain barrier breakdown in Alzheimer's disease.
abstract: Increased Aβ clearance from brain is essential for restoring the pathological manifestation of Alzheimer's disease (AD) and attenuating the cognitive disorder. The blood-brain barrier (BBB) plays a critical role in maintaining homeostasis of the brain, and transporters e.g. P-glycoprotein (P-gp) are essential for Aβ clearance from the brain. In addition, the Wnt/β-catenin signaling pathway contributes to BBB formation, induction and maturation, and induces BBB function. Dysfunctional Wnt/β-catenin signaling in the BBB reveals the importance of this pathway, since this contributes to the neurodegeneration characteristic of AD. Based on the above evidence, we propose that targeting the canonical Wnt signaling pathway could be promising therapeutic approach for treatment of AD.
authors.affiliation: Geriatrics Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 20040, PR China. Electronic address: yyliulumei@gmail.com.
authors.forename: Lumei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Geriatrics Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 20040, PR China. Electronic address: wwb3412@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Wan
authors.affiliation: Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 20040, PR China. Electronic address: xiashijinhd@163.com.
authors.forename: Shijin
authors.initials: S
authors.lastname: Xia
authors.affiliation: Department of Perinatal Medicine Pregnancy Research Center and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, VIC 3052, Australia. Electronic address: Bill.Kalionis@thewomens.org.au.
authors.forename: Bill
authors.initials: B
authors.lastname: Kalionis
authors.affiliation: Geriatrics Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 20040, PR China. Electronic address: doctorymli@163.com.
authors.forename: Yaming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001812:Blood-Brain Barrier; D006801:Humans; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin
keywords: Alzheimer’s disease; Blood–brain barrier; Central nervous system; Wnt/β-catenin signaling pathway; β-Amyloid