title: Within-patient variability in immunosuppressive drug exposure as a predictor for poor outcome after transplantation.
abstract: Within-patient variability in immunosuppressive drug exposure is easily identified by measurement of drug concentrations at the outpatient clinic. Fluctuating levels despite a stable drug dose can be observed in a substantial proportion of patients. It has now been shown that this within-patient variability is a predictor for poor long-term outcome after transplantation. Nonadherence most likely is an important determinant of variability, and strategies to tackle nonadherence are being developed.
authors.affiliation: 1] Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Teun
authors.initials: T
authors.lastname: van Gelder
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D016559:Tacrolimus / Q000097:blood*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus