title: Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder.
abstract: The pumpkin seed oil obtained from Cucurbita pepo has been shown to be useful for the treatment of nocturia in patients with urinal disorders in several western countries. In this study, we evaluated the effect of the pumpkin seed oil from Cucurbita maxima on urinary dysfunction in human overactive bladder (OAB). Forty-five subjects were enrolled in this study. An extract of pumpkin seed oil from C. maxima (10 g of oil/day) was orally administrated for 12 weeks. After 6 and 12 weeks, urinary function was evaluated using Overactive Bladder Symptom Score (OABSS). Pumpkin seed oil from C. maxima significantly reduced the degree of OABSS in the subjects. The results from our study suggest that pumpkin seed oil extracts from C. maxima as well as from C. pepo are effective for urinary disorders such as OAB in humans.
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan. ; Section of Research and Development, Hokkaido Food Industry Promotion Organization, Sapporo, Japan.
authors.forename: Mie
authors.initials: M
authors.lastname: Nishimura
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan. ; Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohkawara
authors.affiliation: Section of Research and Development, Hokushin Foods, Co. Ltd, Ebetsu, Japan.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Sato
authors.affiliation: Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-441, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
keywords: Cucurbita maxima; Overactive bladder; Pumpkin seed oil