title: Targeting the homologous recombination pathway by small molecule modulators.
abstract: During the last decade, the use of small molecule (MW <500 Da) compounds that modulate (inhibit or activate) important proteins of different biological pathways became widespread. Recently, the homologous recombination (HR) pathway emerged as a target for such modulators. Development of small molecule modulators pursues two distinct but not mutually exclusive purposes: to create a research tool to study the activities or functions of proteins of interest and to produce drugs targeting specific pathologies. Here, we review the progress of small molecule development in the area of HR.
authors.affiliation: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, United States.
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
authors.affiliation: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, United States. Electronic address: amazin@drexelmed.edu.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Mazin
mesh_terms: D000818:Animals; D059765:Homologous Recombination / Q000187:drug effects*; D006801:Humans; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D054852:Small Molecule Libraries
keywords: BLM; DNA double stranded breaks; DNA repair; RAD51; RAD54; WRN