title: Impact of platelet transfusion on survival of patients with intracerebral hemorrhage after administration of anti-platelet agents at a tertiary emergency center.
abstract: This study examined the impact of platelet transfusion (PLT) on the survival of intracerebral hemorrhage (ICH) patients who had been administered anti-platelet agents (APA). This retrospective cohort analysis investigated 432 patients (259 men, 60%) who were newly diagnosed with ICH between January 2006 and June 2011 at the tertiary emergency center of Kitasato University Hospital. Median age on arrival was 67.0 years (range, 40-95 years). ICH was subcortical in 72 patients (16.7%), supratentorial in 233 (53.9%), and infratentorial in 133 (30.8%). PLT was performed in 16 patients (3.7%). Within 90 days after admission to the center, 178 patients (41.2%) had died due to ICH. Before the onset of ICH, 66 patients had been prescribed APA because of atherosclerotic diseases. Multivariate regression analysis indicated APA administration was an independent risk factor for death within 7 days (odds ratio, 5.12; P = 0.006) and within 90 days (hazard ratio, 1.87; P = 0.006) after arrival. Regarding the effect of a PLT in ICH patients with APA, no patient with PLT died. PLT had a survival benefit on patients with ICH, according to our analysis. Further prospective analysis is necessary to confirm the effects of PLT on survival in ICH with APA.
authors.affiliation: Departments of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Fukushima, Japan.
authors.forename: Yuhko
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Departments of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kitahara
authors.affiliation: Departments of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Kazui
authors.initials: K
authors.lastname: Soma
authors.affiliation: Departments of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Konno
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Sachio
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oka
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujii
authors.affiliation: Department of Neurosurgery, Fuchinobe General Hospital, Sagamihara, Kanagawa, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitahara
authors.affiliation: Department of Neurosurgery, Ashigarakami Hospital, Ashigarakami, Kanagawa, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Neurosurgery, Sagamihara-chuo Hospital, Sagamihara, Kanagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Otsuka
authors.affiliation: Department of Neurology, Fukushima Medical University, Fukushima, Fukushima, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sugiura
authors.affiliation: Department of Clinical Laboratory Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: Yuhsaku
authors.initials: Y
authors.lastname: Kanoh
authors.affiliation: Department of Transfusion, Hirosaki University School of Medicine, Hirosaki, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tamai
authors.affiliation: Departments of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Fukushima, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000628:therapy*; D015331:Cohort Studies; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D017713:Platelet Transfusion / Q000379:methods*; D012044:Regression Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D062606:Tertiary Care Centers
chemical_list: D010975:Platelet Aggregation Inhibitors