title: Current status of gene expression profiling to assist decision making in stage II colon cancer.
abstract: The decision regarding adjuvant therapy for patients with stage II colon cancer remains a challenge. In contrast to stage III colon cancer, for which compelling clinical data support the use of adjuvant chemotherapy, the clinical benefit of systemic therapy in unselected patients with stage II disease is modest at best. Risk stratification based on clinicopathologic features and DNA mismatch repair status is commonly used in adjuvant therapy decisions, but these factors do not have a desired level of precision in identifying patients at high risk. Recently, gene expression platforms have been developed to further define risk and to assist in therapeutic decision making for patients with stage II disease. This review describes those platforms that are furthest along in clinical development, in an effort to place their potential clinical application in context.
authors.affiliation: University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA Cheng.Chee@UHhospitals.org.
authors.forename: Cheng E
authors.initials: CE
authors.lastname: Chee
authors.affiliation: University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
authors.forename: Neal J
authors.initials: NJ
authors.lastname: Meropol
mesh_terms: D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D003657:Decision Making; D020869:Gene Expression Profiling; D006801:Humans; D009367:Neoplasm Staging
keywords: Adjuvant therapy; Colon cancer; Genomic profiling; Stage II