title: Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections.
abstract: Dengue is the most prevalent arthropod-borne viral illness in humans. A MHC class I polypeptide-related sequence B (MICB) single nucleotide polymorphism (SNP) was previously associated with symptomatic dengue compared to non-dengue causes of acute febrile illnesses in infants. We measured circulating levels of soluble (s)MICB in the sera of infants with symptomatic primary dengue virus infections. We found that serum levels of sMICB increased between pre-infection and acute illness among infants with symptomatic primary dengue virus infections. The likelihood of being hospitalized with an acute primary DENV infection during infancy also tended to be higher with increasing acute illness sMICB levels. The elevation of sMICB during acute primary DENV infections in infants likely represents an immune evasion strategy and contributes to the severity of the acute illness.
authors.affiliation: Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Libraty
authors.affiliation: Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Medicine, Research Institute for Tropical Medicine, Manila, Philippines.
authors.forename: AnaMae
authors.initials: A
authors.lastname: Obcena
authors.affiliation: San Pablo City Health Office, San Pablo, Philippines.
authors.forename: Job D
authors.initials: JD
authors.lastname: Brion
authors.affiliation: Department of Medicine, Research Institute for Tropical Medicine, Manila, Philippines; Department of Microbiology, Research Institute for Tropical Medicine, Manila, Philippines.
authors.forename: Rosario Z
authors.initials: RZ
authors.lastname: Capeding
mesh_terms: D003715:Dengue / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D015395:Histocompatibility Antigens Class I / Q000097:blood* / Q000276:immunology*; D006801:Humans; D007223:Infant; D010679:Philippines; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018709:Statistics, Nonparametric
chemical_list: D015395:Histocompatibility Antigens Class I; C098080:MICB antigen