title: Stem Cells Transplantation and Huntington's Disease.
abstract: Huntington's disease (HD) is a progressive and devastating neurodegenerative disorder that results in movement abnormalities, cognitive impairments, dementia, and affective disturbances. As no proven medical therapy for this genetic disease is currently available, symptoms mitigation is the primary treatment for HD. Stem cells can play an important role in cell therapy therapeutic strategies to replace dysfunctional or dying cells in HD. Here, we present a brief overview of the current state of stem cells therapy and of the results obtained in animal models of HD, and discuss neuro-protective approaches that utilize stem cells-derived paracrine factors.
authors.affiliation: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: Wooseok
authors.initials: W
authors.lastname: Im
authors.affiliation: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea ; Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, Korea.
authors.forename: Soon-Tae
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea ; Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, Korea.
authors.forename: Kon
authors.initials: K
authors.lastname: Chu
authors.affiliation: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea ; Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, Korea.
authors.forename: Manho
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea ; Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, Korea.
authors.forename: Jae-Kyu
authors.initials: JK
authors.lastname: Roh
keywords: Animal model; Huntington’s disease; Stem cells