title: Treatment with topical nitroglycerine may promote the healing process of diabetic foot ulcers.
abstract: Diabetes mellitus is one of the main problems of the health care systems of all societies. A vast number of diabetic patients suffer from diabetic foot ulcers (DFUs) some of which may lead to the amputation of the organ(s). Nitric oxide (NO) is an indigenous gas that is produced at various sites in the body and has been shown to possess important roles in wound healing. Previous studies have shown that not only is the production of NO decreased in diabetic patients but also the sensitivity of the cells of such patients to NO is dramatically reduced. Nitroglycerine (isosorbide dinitrate) can be employed as an effective donor of NO to diabetic wounds. On such a basis, we suggest a novel hypothesis that delivery of compensatory amounts of NO to the ulcers by the administration of topical nitroglycerine enhances blood flow and biochemical activity of the ulcers and thus promotes wound healing.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Mikaili
authors.affiliation: Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Electronic address: miladmoludi@gmail.com.
authors.forename: Milad
authors.initials: M
authors.lastname: Moloudizargari
authors.affiliation: Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: Shahin
authors.initials: S
authors.lastname: Aghajanshakeri
mesh_terms: D000287:Administration, Topical; D017719:Diabetic Foot / Q000188:drug therapy*; D006801:Humans; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009569:Nitric Oxide; D005996:Nitroglycerin