title: Primary systemic therapy and whole breast irradiation for locally advanced breast cancer: a systematic review.
abstract: The current management of locally advanced breast cancer (LABC) is based on tri-modality treatment including chemotherapy, radiotherapy and surgery. The concept of preoperative concurrent or sequential chemoradiation for LABC was initially reported more than a decade ago; however this concept did not gain popularity because of the low benefit/risk ratio and the lack of strong data supporting the concept. The purpose of the current systematic review was to explore the published data about preoperative chemoradiation (sequential and/or concurrent) using whole breast irradiation in terms of toxicity and outcome.
authors.affiliation: Division of Oncology, Rambam Health Care Campus, and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Orit
authors.initials: O
authors.lastname: Kaidar-Person
authors.affiliation: Italian Hospital, Haifa, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Kuten
authors.affiliation: AP-HP. Depratmentof Radiation Onconology and Breast Center of Henri Mondor University Hospital and University Paris-Est Creteil (UPEC), Creteil, France. Electronic address: yazid.belkacemi@hmn.aphp.fr.
authors.forename: Yazid
authors.initials: Y
authors.lastname: Belkacemi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D009369:Neoplasms / Q000628:therapy*; D011379:Prognosis; D011878:Radiotherapy
keywords: Breast cancer; Chemoradiation; Chemotherapy; Irradiation; Neoadjuvant; Preoperative; Radiotherapy