title: Recent advances in synthetic analogues of lantibiotics: What can we learn from these?
abstract: The lantibiotics are a family of antibacterial cyclic peptides distinguished by one or more thioether linkages between amino acid side chains, and by unique modes of action. Recent developments in the chemical synthesis, mutagenesis and mutasynthesis of these peptides are providing insights into the structural requirements for antibacterial activity and into the mode of action, as well as having the potential to produce analogues with greater stability, potency and bioavailability. This Review provides a survey of these recent advances.
authors.affiliation: UCL Department of Chemistry, 20, Gordon Street, London WC1H 0AJ, UK. Electronic address: a.b.tabor@ucl.ac.uk.
authors.forename: Alethea B
authors.initials: AB
authors.lastname: Tabor
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D001430:Bacteriocins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010456:Peptides, Cyclic
keywords: Antibacterial; Lantibiotic; Peptide