title: [The clinical results and lipid peroxidation dynamics in the patients presenting with psoriasis treated by the applications of a natural highly mineralized bromine-iodine brine].
abstract: The authors report the results of the treatment of 64 patients presenting with psoriasis by the applications of a natural highly mineralized bromine-iodine brine. The method has been shown to be highly efficacious and safe. It allowed the clinical remission and marked improvement of the patients' clinical conditions to be achieved in 48 (77.4%) cases compared with 10 (27.8%) cases among the patients of the control group. Exacerbation was documented in a single patient with psoriatic erythrodermia. All the patients showed the normal results of general and biochemical clinical analyses of blood and urea throughout the study period. The applications of the natural highly mineralized bromine-iodine brine exerted the normalizing action on seven of the 8 characteristics of the lipid peroxidation process. It is maintained that the high effectiveness of the method in question can be accounted not only by the reflectory and humoral mechanisms of action of highly mineralized bromine-iodine brine but also by the marked exhaustion of the functional reserves of the mast cells under effect of the applications. It is concluded that an advantage of the proposed approach over standard balneotherapeutic procedures consists of the possibility to employ it not only at the base of a spa and health resort facility but also in a different setting with the involvement of the patients suffering from progressive psoriasis.
authors.forename: V D
authors.initials: VD
authors.lastname: El'kin
authors.forename: I P
authors.initials: IP
authors.lastname: Koriukina
authors.forename: Ia S
authors.initials: IaS
authors.lastname: Datskovskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Plotnikova
mesh_terms: D000287:Administration, Topical; D001494:Baths / Q000379:methods*; D001966:Bromine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011565:Psoriasis / Q000097:blood* / Q000628:therapy*; D012492:Salts / Q000008:administration & dosage*
chemical_list: D012492:Salts; C017082:brine; D007455:Iodine; D001966:Bromine