title: Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.
abstract: Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.
authors.affiliation: Cancer Research Centre at Mercogliano (CROM), Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, 80131 Naples, Italy.
authors.forename: Giovanni
authors.identifier: 0000-0001-6166-2620
authors.initials: G
authors.lastname: Pagano
authors.affiliation: Cancer Research Centre at Mercogliano (CROM), Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, 80131 Naples, Italy.
authors.forename: Annarita Aiello
authors.identifier: 0000-0001-9539-0205
authors.initials: AA
authors.lastname: Talamanca
authors.affiliation: Cancer Research Centre at Mercogliano (CROM), Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, 80131 Naples, Italy.
authors.forename: Giuseppe
authors.identifier: 0000-0002-0924-6248
authors.initials: G
authors.lastname: Castello
authors.affiliation: Research Laboratory, Dental School, Sevilla University, 41009 Sevilla, Spain.
authors.forename: Mario D
authors.identifier: 0000-0003-0151-3644
authors.initials: MD
authors.lastname: Cordero
authors.affiliation: Department of Chemical Sciences, Federico II University, 80126 Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: d'Ischia
authors.affiliation: National Research Council, Institute of Biomembranes and Bioenergetics, 70126 Bari, Italy.
authors.forename: Maria Nicola
authors.initials: MN
authors.lastname: Gadaleta
authors.affiliation: CIBERER, University of Valencia-INCLIVA, 46010 Valencia, Spain.
authors.forename: Federico V
authors.initials: FV
authors.lastname: Pallardó
authors.affiliation: "Vinca" Institute of Nuclear Sciences, University of Belgrade, 11070 Belgrade, Serbia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Petrović
authors.affiliation: Department of Clinical and Dental Sciences, Polytechnical University of Marche, 60100 Ancona, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Tiano
authors.affiliation: Department of Genetics, ASL Napoli 1, 80136 Naples, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Zatterale
mesh_terms: D000375:Aging; D001327:Autoimmune Diseases / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress