title: Gastroprotective Effects of Glutinous Rice Extract against Ethanol-, Indomethacin-, and Stress-induced Ulcers in Rats.
abstract: This study was designed to evaluate the efficacy of an orally administered aqueous extract of glutinous rice (GRE) to protect against acute gastric mucosal lesions induced by ethanol, indomethacin, and water immersion restraint stress in rats and to characterize the active substances responsible for the protection. GRE was shown to dose-dependently prevent the gastric lesions induced by the above ulcerogenic treatments at doses of 30 to 300 mg/kg. GRE treatment increased the gastric mucin content and partially blocked the ethanol-induced depletion of the gastric mucus layer. Also, it increased the nonprotein sulfhydryl concentration in the gastric mucosa. The gastroprotective action of GRE was markedly enhanced by co-treatment with 4-8 mg/kg tea extracts. The activity of GRE was completely lost by heat treatment at 80℃ for 3 min or treatment with 0.01% pepsin at 37℃ for 1 h. Protein extraction studies indicated that prolamins are involved in the gastroprotective activity of GRE. Our results suggest that glutinous rice proteins are useful for the prevention and treatment of gastritis and peptic ulcer.
authors.affiliation: Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Dong Up
authors.initials: DU
authors.lastname: Song
authors.affiliation: Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Jang
authors.affiliation: Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hyun Joong
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Kee Oh
authors.initials: KO
authors.lastname: Chay
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Joo
authors.affiliation: Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young Do
authors.initials: YD
authors.lastname: Jung
authors.affiliation: Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sung Yeul
authors.initials: SY
authors.lastname: Yang
authors.affiliation: Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Bong Whan
authors.initials: BW
authors.lastname: Ahn
keywords: Gastroprotection; Glutinous rice; Prolamins; Proteins; Ulcer