title: A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH.
abstract: We demonstrate a new small molecule fluorescent probe, possessing near-infrared (NIR) emission and an unusually large Stokes shift. It can be readily taken up by live cells and mitochondria, and track subtle pH changes with effectively reduced biological background fluorescence and improved measurement accuracy.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. tangb@sdnu.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Haibin
authors.initials: H
authors.lastname: Xiao
authors.forename: Yinfang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides; D051379:Mice; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism*; D061848:Optical Imaging; D010538:Peritonitis / Q000139:chemically induced / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D015027:Zebrafish
chemical_list: C000597393:3-(2-chloro-3-(2-(1-ethyl-3,3-dimethylindolin-2-ylidene)ethylidene)cyclohex-1-enyl)-1-(4-(dimethylamino)phenyl)prop-2-en-1-one; D000814:Aniline Compounds; D005456:Fluorescent Dyes; D007211:Indoles; D008070:Lipopolysaccharides