title: Attenuation of mismatch negativity (MMN) and novelty P300 in schizophrenia patients with auditory hallucinations experiencing acute exacerbation of illness.
abstract: This study examined measures of early auditory feature analysis, including the mismatch negativity (MMN) and novelty P300 (NP3) in schizophrenia patients (SZ) with persistent auditory hallucinations (AH) during an acute psychotic episode requiring hospitalisation. Neuroelectric activity was recorded in 10 SZ patients and 13 healthy controls (HC) during a passive auditory oddball task including novel environmental sounds. MMN/NP3 amplitudes and latencies were compared between groups and were correlated with trait (PSYRATS) and state measures of AH severity as well as clinical symptom ratings in SZs.SZ patients (vs. HCs) exhibited reduced MMN amplitudes to both rare deviant and novel stimuli, as well as reduced NP3 amplitudes. Additionally, while novelty MMN amplitudes were correlated with measures of hallucinatory trait, NP3 amplitudes were correlated with measures of hallucinatory state. Therefore, in acutely ill SZ patients, individual components of the auditory novelty detection mechanism may be differentially sensitive to varying aspects of AHs.
authors.affiliation: Department of Psychology, Mount Saint Vincent University, Halifax, Nova Scotia, Canada; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada; University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada. Electronic address: derek.fisher@msvu.ca.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Fisher
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Dylan M
authors.initials: DM
authors.lastname: Smith
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Labelle
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Verner J
authors.initials: VJ
authors.lastname: Knott
mesh_terms: D000161:Acoustic Stimulation; D000208:Acute Disease / Q000523:psychology; D000293:Adolescent; D000328:Adult; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006212:Hallucinations / Q000150:complications* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D013223:Statistics as Topic; D055815:Young Adult
keywords: Acute illness; Auditory event-related potentials; Auditory hallucinations; MMN; Mismatch negativity; NP3; Novelty P300; P300a; Schizophrenia