title: [Degenerative and regenerative changes in hippocampus in postnatal ontogenesis].
abstract: OBJECTIVE
  To study the degenerative and regenerative age-related changes in human hippocampus.
  
  
  METHODS
  An immunohistochemical investigation of the hippocampus was carried out in 50 people, aged 25-89 years, who died for different reasons not connected with the cerebral injury or pathology. Expression of the following markers was determined: tau-protein, GFAP, CD105/endoglin, E-selectin, NCAM, Cdk2. Statistical analysis was performed with the program package Biostat.
  
  
  CONCLUSIONS
  Gliogenesis and vasculogenesis processes were active in old and very old age. They may be conditioned by ischemic cerebral injuries and accompany the development of Alzheimer's disease.
authors.forename: N A
authors.initials: NA
authors.lastname: Zimushkina
authors.forename: P V
authors.initials: PV
authors.lastname: Kosareva
authors.forename: V G
authors.initials: VG
authors.lastname: Cherkasova
authors.forename: V P
authors.initials: VP
authors.lastname: Khorinko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism; D019040:E-Selectin / Q000378:metabolism; D000071063:Endoglin; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D019040:E-Selectin; C064206:ENG protein, human; D000071063:Endoglin; D019006:Neural Cell Adhesion Molecules; D011956:Receptors, Cell Surface; C546936:SELE protein, human; D016875:tau Proteins; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2