title: F-18 FDG PET/CT in the evaluation of Takayasu arteritis: an experience from the tropics.
abstract: OBJECTIVE
  To evaluate the performance parameters of FDG PET/CT in patients with Takayasu arteritis at diagnosis and during immunosuppression.
  
  
  METHODS
  Retrospective analysis of 60 FDG PET/CT studies in 51 patients was performed (17 scans at diagnosis out of which 4 had follow-up scans also and 43 scans on immunosuppression). The degree of FDG uptake in the vessels was assessed visually using a 4-point scale and maximum standardized uptake value (SUVmax), SUVratio, extent of vasculitis and association with ESR were calculated.
  
  
  RESULTS
  PET/CT was positive for active vasculitis in all 17 patients at diagnosis. The mean SUVmax and mean SUV ratio of the active areas were 5.1 ± 3.0 and 3.2 ± 1.9, respectively. On immunosuppression, PET scan was positive for active vasculitis in 14/43 (32.5%) scans. The mean SUVmax and mean SUVratio of the active areas were 1.7 ± 2.1 and 0.95 ± 1.2, respectively. There was significant difference between the mean SUVmax and mean SUVratio at diagnosis and on immunosuppression, respectively (P < .01). The median number of vascular segments in each uptake grade group was also statistically different (P < .01) between scans at diagnosis and on immunosuppression. The median ESR level in PET positive scans was 29 mm/hour (2-53), whereas in PET negative scans was 35.5 mm/hour (6-50) and the difference was not statistically significant.
  
  
  CONCLUSIONS
  FDG PET/CT showed good sensitivity to detect active vasculitis at diagnosis and during immunosuppression. The change in SUVmax between the successive FDG PET/CT scans may give an objective assessment of response to immunosuppression.
authors.affiliation: Department of Nuclear Medicine & PET, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
authors.forename: Sampath
authors.initials: S
authors.lastname: Santhosh
authors.forename: Bhagwant Rai
authors.initials: BR
authors.lastname: Mittal
authors.forename: Shankaramurthy
authors.initials: S
authors.lastname: Gayana
authors.forename: Anish
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Aman
authors.initials: A
authors.lastname: Sharma
authors.forename: Sanjay
authors.initials: S
authors.lastname: Jain
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007194:India; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013625:Takayasu Arteritis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014329:Tropical Climate
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18