title: Mucinous breast carcinoma with a lobular neoplasia component: a subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation.
abstract: We investigated whether some mucinous carcinomas (MUCs) are associated with lobular neoplasia (LN) components, and if so, whether this subset has any distinct biological properties. MUC specimens from 41 patients were stratified into pure and mixed types. The LN components adjacent to MUC lesions were examined histopathologically. We also tested immunohistochemically for E-cadherin, β-catenin, and the neuroendocrine markers chromogranin A and synaptophysin; and compared results between MUCs with and without LN. Of 41 patients with MUC, LN was detected in 12 patients (29%); LN alone was the noninvasive component in 8 patients (20%). Decreased E-cadherin and β-catenin expression in the MUC component was detected in 2 (17%) and 7 (58%) cases, respectively, of MUC with LN, compared with 0% (P = 0.080) and 21% (P = 0.018) in MUCs without LN. Neuroendocrine factors were frequently detected in MUCs with LN (42%) and without LN (52%), but tended to be less frequent in MUCs with only LN components (25%) than in other MUCs (55%; P = 0.133). MUCs associated with LN components appear to be a biologically characteristic subset that frequently shows decreased cell-cell adhesion, cell polarity molecules and lack of neuroendocrine differentiation.
authors.affiliation: Breast Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Jimbo
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Akiko
authors.initials: A
authors.lastname: Miyagi-Maeshima
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sasaki-Katsurada
authors.forename: Sota
authors.initials: S
authors.lastname: Asaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Hojo
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D015820:Cadherins / Q000378:metabolism; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D053379:Chromogranin A / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D016708:Synaptophysin / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D053379:Chromogranin A; D016708:Synaptophysin; D051176:beta Catenin
keywords: E-cadherin; breast; lobular neoplasia; mucinous carcinoma; neuroendocrine differentiation; β-catenin