title: Defining the outcome of patients with delayed diagnosis of differentiated thyroid cancer.
abstract: OBJECTIVE
  In the present study we sought to define the outcome of patients with delay in diagnosis and treatment (>1 year) of well-differentiated thyroid carcinoma (WDTC) due to initial benign cytology (IBC).
  
  
  METHODS
  Retrospective medical record review and analysis of survival outcomes.
  
  
  METHODS
  The records of 47 patients with delayed diagnosis of thyroid cancer were reviewed. In 38, surgery was performed for growing nodules and in nine due to malignant cytology during follow-up. Median time to delayed surgery was 52 months (range, 13-205 months). Multivariate analysis was performed to assess variables associated with outcome.
  
  
  RESULTS
  Most patients (32/47) underwent total thyroidectomy, whereas 15/47 had hemithyroidectomy. With a median follow-up of 96 months (range, 12-184 months), the 5-year disease-free survival of these patients was 96%. Multivariate analysis showed that the outcome of these patients was not statistically different than that of patients (n = 162) who underwent immediate surgery for similar disease.
  
  
  CONCLUSIONS
  We show that patients with delayed diagnosis and treatment for WDTC due to IBC have excellent outcome.
  
  
  METHODS
  4.
authors.affiliation: Department of Otolaryngology , Rambam Medical Center, Rappaport School of Medicine, the Technion, Israel Institute of Technology, Haifa.
authors.forename: Moran
authors.initials: M
authors.lastname: Amit
authors.forename: Yaron
authors.initials: Y
authors.lastname: Rudnicki
authors.forename: Yoav
authors.initials: Y
authors.lastname: Binenbaum
authors.forename: Leonor
authors.initials: L
authors.lastname: Trejo-Leider
authors.forename: Jacob T
authors.initials: JT
authors.lastname: Cohen
authors.forename: Ziv
authors.initials: Z
authors.lastname: Gil
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D044963:Biopsy, Fine-Needle; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D013965:Thyroidectomy; D013997:Time Factors
keywords: Thyroid; delayed; fine-needle aspiration; observation; papillary; surgery