title: Preserved glucose metabolism of deep cerebellar nuclei in a case of multiple system atrophy with predominant cerebellar ataxia: f-18 fluorodeoxyglucose positron emission tomography study.
abstract: The cerebellar glucose metabolism of multiple system atrophy with predominant cerebellar ataxia (MSA-C) is known to be decreased but is not defined among areas of cerebellum. We encountered a 54-year-old man who developed dizziness and progressive ataxia followed by urinary incontinence and orthostatic hypotension, all of those symptoms progressed relentlessly and the symptoms responded poorly to levodopa therapy. Visual analysis and statistical parametric mapping analysis of F-18 fluorodeoxyglucose positron emission tomography showed hypometabolism of both cerebellar hemisphere, severe at cortical area, and pons. There was clear sparing of deep cerebellar nuclei. Our report, as we know, shows the first case of preserved glucose metabolism of deep cerebellar nuclei relative to cerebellar cortex in an MSA-C patient.
authors.affiliation: Department of Neurolgy, School of Medicine, Catholic University of Daegu, Daegu Catholic University Medical Center, Daegu, Korea.
authors.forename: Oh Dae
authors.initials: OD
authors.lastname: Kwon
authors.affiliation: Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Chang-Seok
authors.initials: CS
authors.lastname: Ki
keywords: Cerebellar nucleus; F-18 Fluorodeoxyglucose positron emission tomography; Metabolism; Multiple system atrophy