title: [Eradication of Staphylococcus aureus in carrier patients undergoing joint arthroplasty].
abstract: BACKGROUND
  Prosthetic joint infection (PJI) is a complication with serious repercussions and its main cause is Staphylococcus aureus. The purpose of this study is to determine whether decolonization of S.aureus carriers helps to reduce the incidence of PJI by S.aureus.
  
  
  METHODS
  An S.aureus screening test was performed on nasal carriers in patients undergoing knee or hip arthroplasty between January and December 2011. Patients with a positive test were treated with intranasal mupirocin and chlorhexidine soap 5 days. The incidence of PJI was compared with patients undergoing the same surgery between January and December 2010.
  
  
  RESULTS
  A total of 393 joint replacements were performed in 391 patients from the control group, with 416 joint replacements being performed in the intervention group. Colonization study was performed in 382 patients (91.8%), of which 102 were positive (26.7%) and treated. There was 2 PJI due S.aureus compared with 9 in the control group (0.5% vs 2.3%, odds ratio [OR]: 0.2, 95% confidence interval [CI]: 0.4 to 2.3, P=.04).
  
  
  CONCLUSIONS
  In our study, the detection of colonization and eradication of S.aureus carriers achieved a significant decrease in PJI due to S.aureus compared to a historical group.
authors.affiliation: Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, España. Electronic address: j_m_barbero@yahoo.es.
authors.forename: José M
authors.initials: JM
authors.lastname: Barbero Allende
authors.affiliation: Servicio de Microbiología, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Juan
authors.initials: J
authors.lastname: Romanyk Cabrera
authors.affiliation: Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Montero Ruiz
authors.affiliation: Servicio de Cirugía Ortopédica y Traumatológica, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Vallés Purroy
authors.affiliation: Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Virginia
authors.initials: V
authors.lastname: Melgar Molero
authors.affiliation: Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Rosa
authors.initials: R
authors.lastname: Agudo López
authors.affiliation: Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Gete García
authors.affiliation: Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, España.
authors.forename: Joaquín
authors.initials: J
authors.lastname: López Álvarez
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D002353:Carrier State / Q000382:microbiology*; D002710:Chlorhexidine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D016712:Mupirocin / Q000008:administration & dosage; D009666:Nose / Q000382:microbiology; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D016712:Mupirocin; D002710:Chlorhexidine
keywords: Infecciones relacionadas con prótesis; Nasal carriers; Portadores nasales; Prosthesis-related infections; Staphylococcus aureus