title: Performance of magnetic chitosan-alginate core-shell beads for increasing the bioavailability of a low permeable drug.
abstract: This work reports the synthesis and performance of magnetic chitosan-alginate core-shell beads for oral administration of small molecules in order to increase their bioavailability. For this purpose, we designed magnetic core-shell beads suitable for oral delivery that are resistant in acidic media (stomach pH), mucoadhesive, exhibit a superparamagnetic behavior and a very high entrapment efficiency. Ex vivo experiments were performed in Ussing chambers, to emphasize the effect of magnetic accumulation. The amount of drug permeated through the membrane exhibited a threefold increase with our novel drug delivery system. According to a correlation law, our ex vivo model showed that the adsorbed fraction (FA) in human is expected to reach 70% when using the magnetic retention system which is a great improvement when compared to the controls (FA=20%).
authors.affiliation: Sorbonne Universités, Paris, France; Technologie Servier, Orléans, France.
authors.forename: Anjali
authors.initials: A
authors.lastname: Seth
authors.affiliation: Technologie Servier, Orléans, France.
authors.forename: David
authors.initials: D
authors.lastname: Lafargue
authors.affiliation: Technologie Servier, Orléans, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Poirier
authors.affiliation: Technologie Servier, Orléans, France.
authors.forename: Jean-Manuel
authors.initials: JM
authors.lastname: Péan
authors.affiliation: Sorbonne Universités, Paris, France. Electronic address: christine.menager@upmc.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Ménager
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001682:Biological Availability; D048271:Chitosan / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D008280:Magnetics; D008297:Male; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D010599:Pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D048271:Chitosan
keywords: Absorption; Alginate; Bioavailability; Chitosan; Drug delivery; Magnetic particles