title: Investigation of the stabilizing effects of antioxidants and benzophenone-3 on desonide photostability.
abstract: Desonide is a topical corticoid used in the treatment of skin diseases and is marketed in different pharmaceutical dosage forms. Recently, the poor photostability of a commercially available hair solution after direct exposure to UVA light was verified. In this study, we investigated the ability of the antioxidants ascorbic acid, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), α-tocopherol, and the UV filter benzophenone-3 (BP-3) to prevent the photodegradation of desonide in hair solution (desonide 0.1%) and the stability of the proposed formulation under environmental conditions. The tested antioxidants were not able to prevent the photolysis of desonide, whereas the addition of 0.3% BP-3 enhanced the photostability of the drug. After 15 h of direct exposure to UVA radiation, the desonide remaining content in the hair solution with BP-3 was approximately 98%. Higher photostability was also verified under UVC radiation. Additionally, the results indicated that the formulation was stable under accelerated and room temperature conditions for 70 days, corresponding to the total period of the study.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil, priscilarosa.pir@gmail.com.
authors.forename: Priscila
authors.initials: P
authors.lastname: Rosa
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Snovarski Salla
authors.forename: Cristiane
authors.initials: C
authors.lastname: de Bona da Silva
authors.forename: Clarice Madalena
authors.initials: CM
authors.lastname: Bueno Rolim
authors.forename: Andréa Inês
authors.initials: AI
authors.lastname: Horn Adams
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000528:radiation effects; D001577:Benzophenones / Q000737:chemistry* / Q000528:radiation effects; D002626:Chemistry, Pharmaceutical; D003879:Dermatologic Agents / Q000737:chemistry* / Q000528:radiation effects; D003898:Desonide / Q000737:chemistry* / Q000528:radiation effects; D005079:Excipients; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D001577:Benzophenones; D003879:Dermatologic Agents; D005079:Excipients; C005290:oxybenzone; D003898:Desonide