title: Si-jun-zi decoction treatment promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis.
abstract: Intestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to replenish qi and invigorate the functions of the spleen. Modern pharmacological studies show that this prescription can improve gastrointestinal function and strengthen immune function. In this study, we investigated the effects of a famous Chinese herbal formula, Si-Jun-Zi Decoction, on the restoration of intestinal function after the relief of obstruction in a rabbit model. We found that Si-Jun-Zi Decoction could reduce intestinal mucosal injury while promoting the recovery of the small intestine. Further, Si-Jun-Zi Decoction could regulate the intestinal immune system. Our results suggest that Si-Jun-Zi Decoction promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis. Our observations indicate that Si-Jun-Zi Decoction is potentially a therapeutic drug for intestinal obstruction.
authors.affiliation: Department of Gastrointestinal Surgery, Nankai Hospital, Nankai District, Tianjin 300100, China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Graduate School of Tianjin Medical University, Nankai District, Tianjin 300100, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Department of Gastrointestinal Surgery, Nankai Hospital, Nankai District, Tianjin 300100, China.
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Gastrointestinal Surgery, Nankai Hospital, Nankai District, Tianjin 300100, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shan
authors.affiliation: Tianjin Institute of Acute Abdominal Disease of Integrated Traditional Chinese and Western Medicine, Nankai District, Tianjin 300100, China.
authors.forename: Donghua
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Nankai Hospital, Nankai District, Tianjin 300100, China.
authors.forename: Naiqiang
authors.initials: N
authors.lastname: Cui