title: Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells.
abstract: Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Eggimann
authors.forename: Emilyne
authors.initials: E
authors.lastname: Blattes
authors.forename: Stefanie
authors.initials: S
authors.lastname: Buschor
authors.forename: Rasomoy
authors.initials: R
authors.lastname: Biswas
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Kammer
authors.forename: Tamis
authors.initials: T
authors.lastname: Darbre
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Reymond
mesh_terms: D000595:Amino Acid Sequence; D050091:Dendrimers / Q000378:metabolism*; D004705:Endocytosis; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D050091:Dendrimers; D010455:Peptides