title: Synergistic combination therapy using a lipid shell-droplet core nanosphere with tunable thickness.
abstract: A newly-designed drug carrier composed of an internal droplet core and a thickness-controllable shell was successfully developed. By co-delivering paclitaxel, doxorubicin and quantum dots simultaneously, this combinational drug delivery system could achieve in vitro fluorescence imaging, chemotherapeutic and oxidation therapy.
authors.affiliation: Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, 30010, Taiwan. sanyuanchen@mail.nctu.edu.tw.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Su
authors.forename: Ting-Hsi
authors.initials: TH
authors.lastname: Fan
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Li
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000138:chemical synthesis*; D004357:Drug Synergism; D005453:Fluorescence; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage; D045663:Quantum Dots; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D008055:Lipids; D017382:Reactive Oxygen Species; D004317:Doxorubicin; D017239:Paclitaxel