title: Designing an intracellular fluorescent probe for glutathione: two modulation sites for selective signal transduction.
abstract: A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.
authors.affiliation: UNAM-National Nanotechnology Research Centerand §Department of Chemistry, Bilkent University , Ankara 06800, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Işık
authors.forename: Ruslan
authors.initials: R
authors.lastname: Guliyev
authors.forename: Safacan
authors.initials: S
authors.lastname: Kolemen
authors.forename: Yigit
authors.initials: Y
authors.lastname: Altay
authors.forename: Berna
authors.initials: B
authors.lastname: Senturk
authors.forename: Turgay
authors.initials: T
authors.lastname: Tekinay
authors.forename: Engin U
authors.initials: EU
authors.lastname: Akkaya
mesh_terms: D001943:Breast Neoplasms; D005260:Female; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D015398:Signal Transduction
chemical_list: D005456:Fluorescent Dyes; D005978:Glutathione