title: A selective release system based on dual-drug-loaded mesoporous silica for nanoparticle-assisted combination therapy.
abstract: A selective release system was demonstrated with a dual-cargo loaded MSNs. When stimulated by different signals (UV or H(+)), this system could selectively release different kinds of cargoes individually. Furthermore, this system has been used to provide a combination of chemotherapy and biotherapy for cancer treatment. This controlled release system could be an important step in the development of more effective and sophisticated nanomedicine and nanodevices, due to the possibility of selective release of a complex multi-drug.
authors.affiliation: Research Center for Bioengineering & Sensing Technology, School of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing 100083 (P.R. China).
authors.forename: Wenqian
authors.initials: W
authors.lastname: Wang
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wen
authors.forename: Liping
authors.initials: L
authors.lastname: Xu
authors.forename: Hongwu
authors.initials: H
authors.lastname: Du
authors.forename: Yabin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D012822:Silicon Dioxide
keywords: combination therapy; drug delivery; mesoporous materials; nanotechnology; selective release