title: Near misdiagnosis of glioblastoma as primary central nervous system lymphoma.
abstract: Primary central nervous system (CNS) lymphoma, most frequently a diffuse large B-cell lymphoma, is a rare aggressive lymphoma confined to the CNS, thus requiring differentiation from other brain malignancies such as glioblastoma. Although stereotactic biopsy can confirm the diagnosis, this is invasive, not always feasible and can be inconclusive after steroid use. Hence, cranial magnetic resonance imaging (MRI) with contrast and cerebrospinal fluid analysis are frequently used to make a prompt diagnosis. We report a case of a woman with two brain masses who presented unique diagnostic challenge.
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Vijaya Raj
authors.initials: VR
authors.lastname: Bhatt
authors.affiliation: Department of Internal Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI, USA.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Shrestha
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Shonka
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: R Gregory
authors.initials: RG
authors.lastname: Bociek
keywords: Flow cytometry; Glioblastoma; Magnetic resonance imaging; Primary central nervous system lymphoma