title: Acute hand ischemia after unintentional intraarterial injection of drugs: is catheter-directed thrombolysis useful?
abstract: Unintentional intraarterial injections are rare but may have devastating consequences. No consensus on treatment has been established owing to the wide variety of possible injected substances, incomplete understanding of the underlying pathophysiology, and the absence of case-controlled, prospective human studies. The aim of the present study and literature review was to evaluate the benefit of intraarterial thrombolysis combined with systemic anticoagulation therapy when an artery of the upper extremity is accidentally punctured and ischemia of the hand ensues.
authors.affiliation: Departments of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva 14 1211, Switzerland. Electronic address: romain.breguet@hcuge.ch.
authors.forename: Romain
authors.initials: R
authors.lastname: Breguet
authors.affiliation: Departments of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva 14 1211, Switzerland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Terraz
authors.affiliation: Departments of Angiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva 14 1211, Switzerland.
authors.forename: Marc
authors.initials: M
authors.lastname: Righini
authors.affiliation: Departments of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva 14 1211, Switzerland.
authors.forename: Dominique
authors.initials: D
authors.lastname: Didier
mesh_terms: D000208:Acute Disease; D000328:Adult; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D000800:Angioplasty, Balloon; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006225:Hand / Q000098:blood supply*; D006801:Humans; D007049:Iatrogenic Disease; D007269:Injections, Intra-Arterial / Q000009:adverse effects; D007511:Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D015819:Substance Abuse, Intravenous / Q000150:complications*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator
keywords: UIAI; unintentional intraarterial injection