title: Palladium-catalyzed cascade annulation to construct functionalized β- and γ-lactones in ionic liquids.
abstract: A highly efficient and mild palladium-catalyzed, one-pot, four-step cascade annulation has been developed to afford functionalized β- and γ-lactones in moderate to good yields with high regio- and diastereoselectivities in ionic liquids. The employment of ionic liquids under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active β- and γ-lactones.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640 (P. R. China).
authors.forename: Jianxiao
authors.initials: J
authors.lastname: Li
authors.forename: Wanfei
authors.initials: W
authors.lastname: Yang
authors.forename: Shaorong
authors.initials: S
authors.lastname: Yang
authors.forename: Liangbin
authors.initials: L
authors.lastname: Huang
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.forename: Yadong
authors.initials: Y
authors.lastname: Sun
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
keywords: alkynes; annulation; ionic liquids; lactones; palladium