title: Incidence and clinical characteristics of lower urinary tract symptoms as a presenting symptom for patients with newly diagnosed bladder cancer.
abstract: OBJECTIVE
  The incidence of lower urinary tract symptoms (LUTS) as the sole presenting symptom for bladder cancer has traditionally been reported to be low. The objective of this study was to evaluate the prevalence and clinical characteristics of newly diagnosed bladder cancer patients who presented with LUTS in the absence of gross or microscopic hematuria.
  
  
  METHODS
  We queried our database of bladder cancer patients at the Atlanta Veteran's Affairs Medical Center (AVAMC) to identify patients who presented solely with LUTS and were subsequently diagnosed with bladder cancer. Demographic, clinical, and pathologic variables were examined.
  
  
  RESULTS
  4.1% (14/340) of bladder cancer patients in our series presented solely with LUTS. Mean age and Charlson Co-morbidity Index of these patients was 66.4 years (range = 52-83) and 3 (range = 0-7), respectively. Of the 14 patients in our cohort presenting with LUTS, 9 (64.3%), 4 (28.6%), and 1 (7.1%) patients presented with clinical stage Ta, carcinoma in Situ (CIS), and T2 disease. At a median follow-up of 3.79 years, recurrence occurred in 7 (50.0%) patients with progression occurring in 1 (7.1%) patient. 11 (78.6%) patients were alive and currently disease free, and 3 (21.4%) patients had died, with only one (7.1%) death attributable to bladder cancer.
  
  
  CONCLUSIONS
  Our database shows a 4.1% incidence of LUTS as the sole presenting symptom in patients with newly diagnosed bladder cancer. This study suggests that urologists should have a low threshold for evaluating patients with unexplained LUTS for underlying bladder cancer.
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Dobbs
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Lee A
authors.initials: LA
authors.lastname: Hugar
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Louis M
authors.initials: LM
authors.lastname: Revenig
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: SiUsama
authors.initials: S
authors.lastname: Al-Qassab
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Petros
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Chad W
authors.initials: CW
authors.lastname: Ritenour
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Muta M
authors.initials: MM
authors.lastname: Issa
authors.affiliation: Department of Urology, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Canter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D018450:Disease Progression; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors; D018709:Statistics, Nonparametric; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000473:pathology