title: Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome.
abstract: G protein-coupled receptor signaling plays a crucial role in platelet function. Regulators of G protein signaling (RGSs), which accelerate the deactivation of G protein signaling, are expressed in platelets. However, RGS expression has not been studied in the context of aspirin resistance. We compared RGS mRNA levels in platelets from 39 aspirin-resistant patients and 50 aspirin-sensitive patients with metabolic syndrome. Although there were no clinical differences between the two groups, transcripts of RGS2, RGS10, and RGS18 were significantly higher in aspirin-resistant patients than in aspirin-sensitive patients. This study is the first to demonstrate that RGS transcripts are elevated in aspirin-resistant platelets from patients with metabolic syndrome.
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Mao
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Jialin
authors.initials: J
authors.lastname: Su
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
mesh_terms: D000368:Aged; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D010975:Platelet Aggregation Inhibitors; D012313:RNA; D019204:GTP-Binding Proteins; D001241:Aspirin