title: Neurobehavioural changes in patients following brain tumour: patients and relatives perspective.
abstract: OBJECTIVE
  Patients and relatives experiences of behavioural and personality changes following brain tumour were assessed to determine whether these changes are more prominent in the experience of patients with frontal tumours and their relatives as a first step to evaluate the need to develop appropriate support and management of such changes, which have a substantial impact on social functioning, and ultimately to improve quality of life.
  
  
  METHODS
  Patients and relatives rated the patients' current levels of apathy, disinhibition and executive dysfunction on the Frontal Systems Behaviour Scale. Patients also completed the Hospital Anxiety and Depression Scale. The data from 28 patients with frontal tumours and 24 of their relatives, and 27 patients with nonfrontal tumours and 25 of their relatives, were analysed.
  
  
  RESULTS
  Patients with frontal tumours rated themselves significantly higher than patients with nonfrontal tumours on all frontal systems-related behaviours. The number of patients reporting clinical levels of difficulty was significantly greater in patients with frontal tumours for disinhibition. The ratings of relatives of patients with frontal tumours were significantly higher than those of relatives of patients with nonfrontal tumours for apathy. Clinically significant levels of apathy and executive dysfunction were however reported by at least 40 % of patients and relatives regardless of tumour location. Clinical levels of anxiety were reported by significantly more patients with frontal tumours than those with nonfrontal tumours.
  
  
  CONCLUSIONS
  Support and management of behavioural and personality change for patients with brain tumours and their relatives, regardless of tumour location, would be most appropriate.
authors.affiliation: Department of Psychology, Institute of Psychiatry, King's College London, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Gregg
authors.forename: A
authors.initials: A
authors.lastname: Arber
authors.forename: K
authors.initials: K
authors.lastname: Ashkan
authors.forename: L
authors.initials: L
authors.lastname: Brazil
authors.forename: R
authors.initials: R
authors.lastname: Bhangoo
authors.forename: R
authors.initials: R
authors.lastname: Beaney
authors.forename: R
authors.initials: R
authors.lastname: Gullan
authors.forename: V
authors.initials: V
authors.lastname: Hurwitz
authors.forename: A
authors.initials: A
authors.lastname: Costello
authors.forename: L
authors.initials: L
authors.lastname: Yágüez
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology* / Q000523:psychology*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life