title: Effect of methylphenidate on neurocognitive test battery: an evaluation according to the diagnostic and statistical manual of mental disorders, fourth edition, subtypes.
abstract: The aims of this study were to evaluate the neuropsychological characteristics of the restrictive (R) subtype according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition and the attention-deficit/hyperactivity disorder (ADHD) combined (CB) type and predominantly inattentive (PI) type subtypes and to evaluate whether methylphenidate (MPH) affects neurocognitive test battery scores according to these subtypes. This study included 360 children and adolescents (277 boys, 83 girls) between 7 and 15 years of age who had been diagnosed with ADHD and compared the neuropsychological characteristics and MPH treatment responses of patients with the R subtype-which has been suggested for inclusion among the ADHD subtypes in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-with those of patients with the PI and CB subtypes. They did not differ from the control subjects in the complex attention domain, which includes Continuous Performance Test, Stroop test, and Shifting Attention Test, which suggests that the R subtype displayed a lower level of deterioration in these domains compared with the PI and CB subtypes. The patients with the CB and PI subtypes did not differ from the control subjects in the Continuous Performance Test correct response domain, whereas those with the R subtype presented a poorer performance than the control subjects. The R subtype requires a more detailed evaluation because it presented similar results in the remaining neuropsychological evaluations and MPH responses.
authors.affiliation: From the *Behcet Uz State Hospital and †Department of Child and Adolescent Psychiatry, Ege University Faculty of Medicine, Izmir; ‡Department of Preventive Oncology, Hacettepe University Cancer Institute, Ankara; and §Department of Psychological Counseling and Guidance, Ege University Faculty of Education; ∥Department of Psychology, Ege University Faculty of Literature, Izmir, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Durak
authors.forename: Eyup Sabri
authors.initials: ES
authors.lastname: Ercan
authors.forename: Ulku Akyol
authors.initials: UA
authors.lastname: Ardic
authors.forename: Deniz
authors.initials: D
authors.lastname: Yuce
authors.forename: Elif
authors.initials: E
authors.lastname: Ercan
authors.forename: Melis
authors.initials: M
authors.lastname: Ipci
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D008774:Methylphenidate / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate