title: Recent insights on the significance of transcriptomic and metabolomic analysis of male factor infertility.
abstract: Infertility is a worldwide reproductive health problem which affects approximately 15% of couples, with male factor infertility dominating nearly 50% of the affected population. The nature of the phenomenon is underscored by a complex array of transcriptomic, proteomic and metabolic differences which interact in unknown ways. Many causes of male factor infertility are still defined as idiopathic, and most diagnosis tends to be more descriptive rather than specific. As such, the emergence of novel transcriptomic and metabolomic studies may hold the key to more accurately diagnose and treat male factor infertility. This paper provides the most recent evidence underlying the role of transcriptomic and metabolomic analysis in the management of male infertility. A summary of the current knowledge and new discovery of noninvasive, highly sensitive and specific biomarkers which allow the expansion of this area is outlined.
authors.affiliation: Nutrition Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: l.k.lee@usm.my.
authors.forename: L K
authors.initials: LK
authors.lastname: Lee
authors.affiliation: Environment and Occupational Health Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; River Engineering and Urban Drainage Research Centre, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang, Malaysia.
authors.forename: K Y
authors.initials: KY
authors.lastname: Foo
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism*; D008297:Male; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D059467:Transcriptome
chemical_list: D015415:Biomarkers
keywords: Biomarker; Male infertility; Metabolomics; Microarray; Transcriptomics