title: Die another day: a painless path to longevity.
abstract: Riera et al. identify a neuroendocrine circuit that controls longevity and the age-dependent onset of metabolic decline via the pain-transducing channel TRPV1. Thus, pharmacological inhibition of TRPV1 may provide a new approach to treat not only metabolic disorders but also a broader range of age-related pathologies.
authors.affiliation: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany.
authors.forename: Sophie M
authors.initials: SM
authors.lastname: Steculorum
authors.affiliation: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany. Electronic address: bruening@nf.mpg.de.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Brüning
mesh_terms: D000818:Animals; D005260:Female; D008136:Longevity; D008297:Male; D015398:Signal Transduction; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse