title: Towards optimization of the silanization process of hydroxyapatite for its use in bone cement formulations.
abstract: The aim of this work was to provide some fundamental information for optimization of silanization of hydroxyapatite intended for bone cement formulations. The effect of 3-(trimethoxysilyl) propyl methacrylate (MPS) concentration and solvent system (acetone/water or methanol/water mixtures) during HA silanization was monitored by X-ray diffraction (XRD), FTIR spectroscopy and EDX analysis. The effect of silanized HA on the mechanical properties of acrylic bone cements is also reported. It was found that the silanization process rendered hydroxyapatite with lower crystallinity compared to untreated HA. Through EDX, it was observed that the silicon concentration in the HA particles was higher for acetone-water than that obtained for methanol-water system, although the mechanical performance of cements prepared with these particles exhibited the opposite behavior. Taking all these results together, it is concluded that methanol-water system containing MPS at 3wt.% provides the better results during silanization process of HA.
authors.affiliation: Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130, Col. Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico.
authors.forename: Olga G
authors.initials: OG
authors.lastname: Cisneros-Pineda
authors.affiliation: Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130, Col. Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico.
authors.forename: Wilberth
authors.initials: W
authors.lastname: Herrera Kao
authors.affiliation: Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130, Col. Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico.
authors.forename: María I
authors.initials: MI
authors.lastname: Loría-Bastarrachea
authors.affiliation: Centro de Biomateriales, Universidad de la Habana, Avenida Universidad, s/n, e/G y Ronda, C.P. 10600 C. de La Habana, Cuba.
authors.forename: Yaymarilis
authors.initials: Y
authors.lastname: Veranes-Pantoja
authors.affiliation: Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130, Col. Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico.
authors.forename: Juan V
authors.initials: JV
authors.lastname: Cauich-Rodríguez
authors.affiliation: Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130, Col. Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico. Electronic address: manceruc@cicy.mx.
authors.forename: José M
authors.initials: JM
authors.lastname: Cervantes-Uc
mesh_terms: D001843:Bone Cements / Q000737:chemistry* / Q000378:metabolism; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013718:Tensile Strength
chemical_list: D001843:Bone Cements; D008689:Methacrylates; D012821:Silanes; D012997:Solvents; D017886:Durapatite; D012825:Silicon
keywords: Bone cements; Hydroxyapatite; Silane coupling agent