title: Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects.
abstract: A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olfactory related brain response of metabolism by using (18)F-fluorodeoxyglucose-Positron Emission Tomography/Computer Tomography in eleven resting subjects undergoing a neutral and a pure olfactory condition. By contrasting these experimental phases, it was possible to depict a re-organization pattern of default mode network structures in a relatively ecological environment. Moreover, by correlating such pattern with a battery of validated olfactory and neuropsychological tests, our work allowed in showing peculiar correlation data that could cluster the subjects sample in a certain range of normality. We believe the present study could integrate the current knowledge in olfactory research and could be a start-up for future contributions.
authors.affiliation: Tor Vergata" University - Department of Clinical Sciences and Translational Medicine - Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Alessandrini
authors.affiliation: Tor Vergata" University - Department of Clinical Sciences and Translational Medicine - Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Micarelli
authors.affiliation: Tor Vergata" University - Department of Biopathology and Diagnostic Imaging - Rome, Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.affiliation: La Sapienza" University - Department of Psychology, Rome, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Candidi
authors.affiliation: Tor Vergata" University - Department of Clinical Sciences and Translational Medicine - Rome, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bruno
authors.affiliation: Tor Vergata" University - Department of Biopathology and Diagnostic Imaging - Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Pietro
authors.affiliation: Tor Vergata" University - Department of Biopathology and Diagnostic Imaging - Rome, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
authors.affiliation: 1] Institute of Cognitive Sciences and Technologies - CNR - Rome, Italy [2] Karolinska University Hospital - Department of Nuclear Medicine, Stockholm, Sweden.
authors.forename: Marco
authors.initials: M
authors.lastname: Pagani
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009415:Nerve Net / Q000502:physiology*; D055696:Olfactory Perception / Q000502:physiology*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D012016:Reference Values; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose