title: Quality of Life in Patients with Noninfectious Uveitis Treated with or without Systemic Anti-inflammatory Therapy.
abstract: OBJECTIVE
  To compare vision-related (VR-QOL) and health-related quality of life (HR-QOL) in patients with noninfectious uveitis treated with systemic anti-inflammatory therapy versus nonsystemic therapy.
  
  
  METHODS
  A prospective, cross-sectional study design was employed. VR-QOL and HR-QOL were assessed by the 25-Item Visual Function Questionnaire (VFQ-25) and the Short Form 12-Item Health Survey (SF-12), respectively. Multivariate regression analysis was performed to assess the VR-QOL and HR-QOL based on treatment.
  
  
  RESULTS
  Among the 80 patients, the median age was 51 years with 28 males (35%). The adjusted effect of treatment modality on VR-QOL or HR-QOL showed no statistically significant difference in all subscores of VFQ-25 or physical component score (PCS) and mental component score (MCS) of SF-12. Systemic therapy did not compromise VR-QOL or HR-QOL compared to nonsystemic therapy.
  
  
  CONCLUSIONS
  Systemic therapy can be effectively used to control serious cases of noninfectious uveitis without significant relative adverse impact on quality of life.
authors.affiliation: Department of Ophthalmology and Visual Science, Yale University , New Haven, Connecticut , USA .
authors.forename: Wei
authors.initials: W
authors.lastname: Gui
authors.forename: Matthew
authors.initials: M
authors.lastname: Dombrow
authors.forename: Inna
authors.initials: I
authors.lastname: Marcus
authors.forename: Meredith H
authors.initials: MH
authors.lastname: Stowe
authors.forename: Baylah
authors.initials: B
authors.lastname: Tessier-Sherman
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Yang
authors.forename: John J
authors.initials: JJ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014605:Uveitis / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents
keywords: Quality of life; SF-12; VFQ-25; systemic therapy; uveitis