title: Resveratrol attenuates bone cancer pain through the inhibition of spinal glial activation and CX3CR1 upregulation.
abstract: The present study examined the effects of intrathecal use of resveratrol on pain hypersensitivities, spinal glia activation, and CX3CR1 expression in the model of bone cancer pain (BCP). The BCP model was established through intrathecally injecting Walker 256 mammary gland carcinoma cells to Sprague-Dawley rats. We found that spinal CX3CR1 expression and glial activation aggravated after inoculation. Resveratrol (i.t.) attenuated bone cancer-induced pain hypersensitivities, decreased CX3CR1 expression and glial activation in the spine in a BCP model. Resveratrol (i.t.) also attenuated mechanical allodynia resulting from intrathecally injecting fractalkine in rats. Inhibition of spinal glial activation and CX3CR1 upregulation may involve in resveratrol's analgesic effects. These findings demonstrated that resveratrol attenuated pain facilitation through inhibiting spinal glial activation and CX3CR1 upregulation in a BCP model.
authors.affiliation: Affiliated Hospital of Xuzhou Medical College, 99 Huaihai West Road, Xuzhou, Jiangsu, 221002, China; Xuzhou medical College, Xuzhou, 221002, China; Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment, Xuzhou Medical College, Xuzhou, 221002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.forename: Qin
authors.initials: Q
authors.lastname: Fan
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Yin
authors.forename: Chang-Dong
authors.initials: CD
authors.lastname: Yan
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001859:Bone Neoplasms / Q000150:complications*; D000073883:CX3C Chemokine Receptor 1; D006930:Hyperalgesia / Q000188:drug therapy; D007278:Injections, Spinal; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D019707:Receptors, Chemokine / Q000235:genetics*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000700:Analgesics; D000073883:CX3C Chemokine Receptor 1; C516305:CX3CR1 protein, rat; D019707:Receptors, Chemokine; D013267:Stilbenes; D000077185:Resveratrol
keywords: CX3CR1; astrocytes; bone cancer pain; microglia; resveratrol