title: An analysis of the correlation of clinical, endoscopic and histological classifications in Crohn's disease.
abstract: BACKGROUND
  The precise evaluation of Crohn's disease (CD) activity is difficult mainly due to the complex symptoms of the disease. Establishing correlations between the most widely used scales of CD clinical, endoscopic and histopathological activity might help to identify the most accurate scale in the assessment of the course of CD.
  
  
  OBJECTIVE
  Comparison of the results of clinical, endoscopic and histological scales of CD activity, i.e. (Crohn's Disease Activity Index (CDAI) score, Montreal Classification, Crohn's Disease Endoscopic Index of Severity (CDEIS) and D'Haens classification).
  
  
  METHODS
  A group of 62 patients with CD was examined. All individuals underwent medical interview and physical examination. All patients had colonoscopy, at which the extent of the disease was analysed according to Montreal Classification and intensity of mucosal lesion described by CDEIS scale. Biopsy samples were taken during colonoscopy. Crohn's disease activity was evaluated by clinical scales (Montreal Classification - A and B, CDAI), endoscopic scales (Montreal Classification - L, CDEIS) and histopathological classification by D'Haens.
  
  
  RESULTS
  The results of histopathological activity scale of CD by D'Haens correlated only with the results of endoscopic classification CDEIS. The results of CDEIS correlated also with parameter B of Montreal Classification. The analysis of Montreal Classification parameters showed correlations between the age of disease onset (A) and localization of the disease (L). Additionally, correlation of parameter A (age of onset) and B (behaviour of the disease) of Montreal Classification was observed. The values of clinical CDAI scale correlated only with parameter B of Montreal Classification (behaviour of the disease).
  
  
  CONCLUSIONS
  There was a significant correlation between the histological (D'Haens) classification and endoscopic scale (CDEIS), but their results did not correlate with clinical scales. There was no consistent correlation between the clinical scales themselves however the correlations concerned only some parameters assessed, which may be the result of subjective clinicians evaluation of CD activity.
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Lodz, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Durko
authors.affiliation: Department of Nephropathology, Medical University of Lodz, Poland.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Stasikowska-Kanicka
authors.affiliation: Pathomorphology Department, Medical University of Lodz, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wagrowska-Danilewicz
authors.affiliation: Department of Nephropathology, Medical University of Lodz, Poland.
authors.forename: Marian
authors.initials: M
authors.lastname: Danilewicz
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Lodz, Poland.
authors.forename: Ewa I
authors.initials: EI
authors.lastname: Małecka-Panas
keywords: Crohn’s Disease Activity Index; Crohn’s Disease Endoscopic Index of Severity; Crohn’s disease; Montreal Classification