title: (99m)Tc HYNIC-TOC imaging and 177Lu DOTA-octreotate treatment in non-iodine-concentrating dedifferentiated thyroid carcinoma metastases: an unusual alternative diagnosis.
abstract: The value of Tc HYNIC-TOC scintigraphy clarifying skeletal and hepatic-predominant metastatic disease in a 55-year-old woman (diagnosed earlier to have papillary carcinoma thyroid and had undergone total thyroidectomy and radioiodine ablation) is illustrated. The whole-body radioiodine scan and battery of serum tumor markers were normal. Multiple metastatic foci in the liver and skeleton were Tc HYNIC-TOC avid. Serum chromogranin A level was substantially elevated (1771.60 ng/mL). This represents an unusual alternative diagnosis signified by a highly positive scan in the setting of apparent non-iodine-concentrating metastatic disease in a patient of differentiated thyroid carcinoma.
authors.affiliation: From the *Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe; and †Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
authors.forename: Amit
authors.initials: A
authors.lastname: Joshi
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D014916:Whole-Body Irradiation
chemical_list: D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D017481:Receptors, Somatostatin; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; C447941:lutetium Lu 177 dotatate; D015282:Octreotide