title: A system and method for online high-resolution mapping of gastric slow-wave activity.
abstract: High-resolution (HR) mapping employs multielectrode arrays to achieve spatially detailed analyses of propagating bioelectrical events. A major current limitation is that spatial analyses must currently be performed "off-line" (after experiments), compromising timely recording feedback and restricting experimental interventions. These problems motivated development of a system and method for "online" HR mapping. HR gastric recordings were acquired and streamed to a novel software client. Algorithms were devised to filter data, identify slow-wave events, eliminate corrupt channels, and cluster activation events. A graphical user interface animated data and plotted electrograms and maps. Results were compared against off-line methods. The online system analyzed 256-channel serosal recordings with no unexpected system terminations with a mean delay 18 s. Activation time marking sensitivity was 0.92; positive predictive value was 0.93. Abnormal slow-wave patterns including conduction blocks, ectopic pacemaking, and colliding wave fronts were reliably identified. Compared to traditional analysis methods, online mapping had comparable results with equivalent coverage of 90% of electrodes, average RMS errors of less than 1 s, and CC of activation maps of 0.99. Accurate slow-wave mapping was achieved in near real-time, enabling monitoring of recording quality and experimental interventions targeted to dysrhythmic onset. This work also advances the translation of HR mapping toward real-time clinical application.
authors.forename: Simon H
authors.initials: SH
authors.lastname: Bull
authors.forename: Gregory
authors.initials: G
authors.lastname: O'Grady
authors.forename: Peng
authors.initials: P
authors.lastname: Du
authors.forename: Leo K
authors.initials: LK
authors.lastname: Cheng
mesh_terms: D000465:Algorithms; D000818:Animals; D004594:Electrophysiology / Q000379:methods*; D005260:Female; D006801:Humans; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013270:Stomach / Q000502:physiology*; D013552:Swine