title: Acute responses of regional vascular conductance to oral ingestion of fructose in healthy young humans.
abstract: BACKGROUND
  Recently, it was reported in healthy young subjects that fructose containing drinks increased blood pressure acutely, without any apparent change in total vascular conductance (TVC). However, because it is well known that the splanchnic vasculature is dilated by oral fructose ingestion, it is assumed to be the concomitant vasoconstriction in other peripheral region(s) that is responsible for this finding. Thus, the purpose of this study was to determine the acute response of regional VC to oral fructose ingestion in young healthy humans.
  
  
  RESULTS
  In 12 healthy young subjects, mean arterial blood pressure (MAP), heart rate, cardiac output, and blood flow (BF) in the superior mesenteric (SMA), brachial (BA), and popliteal (PA) arteries, in addition to forearm skin BF, were measured continuously for 2 h after ingestion of 400 ml fructose solution (containing 50 g fructose). Regional VC was calculated as BF/MAP. MAP increased for 120 min after fructose ingestion without any change in TVC. While VC in the SMA was elevated after ingestion, VC in BA and PA and forearm skin decreased.
  
  
  CONCLUSIONS
  While TVC was apparently unchanged during the 2 h after fructose ingestion, there were coincident changes in regional VCs in the peripheral circulation, but no net change in TVC.
authors.forename: Masako Y
authors.initials: MY
authors.lastname: Endo
authors.forename: Chizuko
authors.initials: C
authors.lastname: Fujihara
authors.forename: Chinami
authors.initials: C
authors.lastname: Yamazaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kashima
authors.forename: Kouhei
authors.initials: K
authors.lastname: Eguchi
authors.forename: Akira
authors.initials: A
authors.lastname: Miura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Fukuoka
authors.affiliation: Department of Exercise Science and Physiology, School of Health Sciences, Prefectural University of Hiroshima, 1-1-71 Ujina-higashi, Minami-ku, Hiroshima, 734-8558, Japan. fukuba@pu-hiroshima.ac.jp.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Fukuba
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects*; D055815:Young Adult
chemical_list: D005632:Fructose