title: ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease.
abstract: The genotype distribution of two gene polymorphisms, previously associated with peripheral artery disease (PAD), has been evaluated in a population of diabetic (DPAD) and non-diabetic (NDPAD) patients affected by symptomatic PAD (stages II-IV). A decreased frequency of the AA genotype of rs5498 (ICAM-1) was observed in the PAD subjects compared to controls but this result did not reach statistical significance (p=0.06 by chi-squared test). On the contrary, a significant increase in the frequency of the GG homozygous genotype of rs248793 (SRD5A1) was observed in the PAD patient group in comparison to controls (p=0.01). These data confirm that the GG genotype of rs248793 in the SRD5A1 gene is significantly associated with symptomatic PAD and show a trend towards a stronger association with the non-diabetic status.
authors.affiliation: Department of Bio-Medical Sciences, Section of Biochemistry, University of Catania, Catania, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Barresi
authors.affiliation: Department of Medicine and Pediatrics, University of Catania, Catania, Italy.
authors.forename: Salvatore S
authors.initials: SS
authors.lastname: Signorelli
authors.affiliation: Department of Bio-Medical Sciences, Section of Biochemistry, University of Catania, Catania, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Musso
authors.affiliation: Department of Medicine and Pediatrics, University of Catania, Catania, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Anzaldi
authors.affiliation: Department of Medicine and Pediatrics, University of Catania, Catania, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Fiore
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Alberghina
authors.affiliation: Department of Bio-Medical Sciences, Section of Biochemistry, University of Catania, Catania, Italy daniele.condorelli@unict.it.
authors.forename: Daniele Filippo
authors.initials: DF
authors.lastname: Condorelli
keywords: ICAM1; SRD5A1; atherosclerosis; diabetes; peripheral artery disease; single nucleotide polymorphism