title: Treatment outcome of mineral trioxide aggregate: repair of root perforations-long-term results.
abstract: BACKGROUND
  This historical cohort study follows on a previously reported trial, with the aim of assessing the outcome for teeth with root perforations managed by the orthograde placement of mineral trioxide aggregate (MTA) and identifying potential outcome factors for such treatment with a larger sample size and longer follow-up periods than in the first phase of the project.
  
  
  METHODS
  The treatment outcomes of 64 root perforations repaired between 2000 and 2012 with MTA were investigated. The root perforations were located in different areas of the root. Calibrated examiners assessed clinical and radiographic outcomes by using standardized follow-up protocols 12-107 months after treatment (median, 27.5 months). Preoperative, intraoperative, and postoperative information was evaluated. The outcomes were dichotomized as healed or diseased.
  
  
  RESULTS
  Of the 64 teeth examined (85% recall rate), 86% were healed. The univariate analyses (χ(2) tests) identified 2 potential prognostic factors, experience of the treatment providers (odds ratio, 2.14; 95% confidence interval, 0.39-11.74; P < .01) and placement of a post after treatment (odds ratio, 0.06; 95% confidence interval, 0.01-0.27; P < .01). In the multivariate stepwise logistic Cox regression, none of the potential prognostic factors displayed a significant effect on the outcome at the 5% level.
  
  
  CONCLUSIONS
  MTA appears to have good long-term sealing ability for root perforations regardless of the location. The results of this historical cohort study confirm the results of the first phase of this project.
authors.affiliation: Division of Endodontics and Dental Traumatology, Department of Conservative Dentistry, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany. Electronic address: johannes.mente@med.uni-heidelberg.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Mente
authors.affiliation: Division of Endodontics and Dental Traumatology, Department of Conservative Dentistry, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
authors.forename: Meltem
authors.initials: M
authors.lastname: Leo
authors.affiliation: Department of Prosthodontics, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
authors.forename: Dimos
authors.initials: D
authors.lastname: Panagidis
authors.affiliation: Institute of Medical Biometry and Informatics, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Saure
authors.affiliation: Division of Endodontics and Dental Traumatology, Department of Conservative Dentistry, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Pfefferle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017607:Aluminum Compounds / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000145:classification; D015331:Cohort Studies; D003751:Dental Fistula / Q000145:classification; D003786:Dental Pulp Cavity / Q000000981:diagnostic imaging / Q000293:injuries; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000145:classification; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000145:classification; D010514:Periodontal Pocket / Q000145:classification; D011859:Radiography; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012391:Root Resorption / Q000628:therapy; D017640:Silicates / Q000627:therapeutic use*; D014082:Tooth Fractures / Q000000981:diagnostic imaging; D014086:Tooth Mobility / Q000145:classification / Q000628:therapy; D014092:Tooth Root / Q000000981:diagnostic imaging / Q000293:injuries*; D019553:Tooth, Nonvital / Q000000981:diagnostic imaging / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate
keywords: MTA; Mineral trioxide aggregate; perforation repair; root perforation; treatment outcome