title: Palladium-catalyzed synthesis of heterocycle-containing diarylmethanes through Suzuki-Miyaura cross-coupling.
abstract: The heterocycle-containing diarylmethane synthesis from chloromethyl(hetero)arenes with (hetero)arylboron reagents was attained using the palladium/ether-imidazolium chloride system. This coupling process tolerated a diverse range of heteroaromatic moieties with sufficient catalytic activity to achieve the efficient synthesis of various diheteroarylmethanes in good to excellent yields.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University , 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Kuriyama
authors.forename: Mina
authors.initials: M
authors.lastname: Shinozawa
authors.forename: Norihisa
authors.initials: N
authors.lastname: Hamaguchi
authors.forename: Seira
authors.initials: S
authors.lastname: Matsuo
authors.forename: Osamu
authors.initials: O
authors.lastname: Onomura
mesh_terms: D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D007093:Imidazoles; D010165:Palladium; C029899:imidazole