title: A histone point mutation that switches on autophagy.
abstract: The multifaceted process of aging inevitably leads to disturbances in cellular metabolism and protein homeostasis. To meet this challenge, cells make use of autophagy, which is probably one of the most important pathways preserving cellular protection under stressful conditions. Thus, efficient autophagic flux is required for healthy aging in many if not all eukaryotic organisms. The regulation of autophagy itself is affected by changing metabolic conditions, but the precise metabolic circuitries are poorly understood. Recently, we found that the nucleocytosolic pool of acetyl-coenzyme A (AcCoA) functions as a major and dominant suppressor of cytoprotective autophagy during aging. Here, we propose an epigenetic mechanism for AcCoA-mediated autophagy suppression that causally involves the regulation of histone acetylation and changes in the autophagy-relevant transcriptome.
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Tobias
authors.initials: T
authors.lastname: Eisenberg
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Schroeder
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Büttner
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Didac
authors.initials: D
authors.lastname: Carmona-Gutierrez
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Tobias
authors.initials: T
authors.lastname: Pendl
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Andryushkova
authors.affiliation: INSERM U848; Pavillon de Recherche 1; Villejuif, France; Metabolomics and Cell Biology Platforms; Institut Gustave Roussy; Pavillon de Recherche 1; Villejuif, France; Université Paris Sud, Faculté de Médecine; Le Kremlin Bicêtre; Paris, France.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Mariño
authors.affiliation: INSERM U848; Pavillon de Recherche 1; Villejuif, France; Metabolomics and Cell Biology Platforms; Institut Gustave Roussy; Pavillon de Recherche 1; Villejuif, France; Université Paris Sud, Faculté de Médecine; Le Kremlin Bicêtre; Paris, France.
authors.forename: Federico
authors.initials: F
authors.lastname: Pietrocola
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria; Division of Endocrinology and Metabolism; Department of Internal Medicine; Medical University of Graz; Graz, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Harger
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmermann
authors.affiliation: HEALTH-Institute for Biomedicine and Health Sciences; Joanneum Research Forschungsgesellschaft m.b.H.; Graz, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Magnes
authors.affiliation: Division of Endocrinology and Metabolism; Department of Internal Medicine; Medical University of Graz; Graz, Austria; HEALTH-Institute for Biomedicine and Health Sciences; Joanneum Research Forschungsgesellschaft m.b.H.; Graz, Austria.
authors.forename: Frank
authors.initials: F
authors.lastname: Sinner
authors.affiliation: Department of Cardiology; Medical University of Graz; Graz, Austria.
authors.forename: Simon
authors.initials: S
authors.lastname: Sedej
authors.affiliation: Division of Endocrinology and Metabolism; Department of Internal Medicine; Medical University of Graz; Graz, Austria; HEALTH-Institute for Biomedicine and Health Sciences; Joanneum Research Forschungsgesellschaft m.b.H.; Graz, Austria.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Pieber
authors.affiliation: Department of Dermatology; University Freiburg Medical Center; Freiburg, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Dengjel
authors.affiliation: Institute for Biology/Genetics; Freie Universität; Berlin, Germany; NeuroCure, Charité; Berlin, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Sigrist
authors.affiliation: INSERM U848; Pavillon de Recherche 1; Villejuif, France; Metabolomics and Cell Biology Platforms; Institut Gustave Roussy; Pavillon de Recherche 1; Villejuif, France; Université Paris Sud, Faculté de Médecine; Le Kremlin Bicêtre; Paris, France; Equipe 11 Labellisée Ligue Contre le Cancer; INSERM U1138; Centre de Recherche des Cordeliers; Paris, France; Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP; Paris, France; Université Paris Descartes; Sorbonne Paris Cité; Paris, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.affiliation: Institute of Molecular Biosciences; University of Graz; Graz, Austria.
authors.forename: Frank
authors.initials: F
authors.lastname: Madeo
mesh_terms: D000818:Animals; D001343:Autophagy; D003066:Coenzyme A Ligases / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D008136:Longevity
chemical_list: D029721:Drosophila Proteins; D003066:Coenzyme A Ligases
keywords: ATG; acetyl-coenzyme A; aging; autophagy; epigenetic; histone acetylation; transcription