title: Pandemic influenza A (H1N1) infection in pregnant and nonpregnant women in Spain (2009-2010).
abstract: The present study aimed to compare the main features of infection with pandemic influenza A virus in pregnant and nonpregnant women admitted to hospitals in Spain during the first waves of the 2009-2010 influenza pandemic. This was a prospective (November 2009 to June 2010), multicenter observational study. All cases were women of reproductive age who had not been vaccinated against seasonal or pandemic influenza A. Influenza infection was confirmed by reverse transcription-polymerase chain reaction (RT-PCR). The sociodemographic and clinical data of all cases were reviewed. A total of 219 inpatients, including 49 pregnant women and 170 nonpregnant women, were enrolled in the study upon admission to participating hospitals. The most substantially different symptoms between the groups were respiratory distress and unilobar consolidation, both of which were more frequent among nonpregnant women. Antibiotics and systemic corticosteroids were more frequently used in nonpregnant women; however, there were no differences in the rates of treatment with antivirals. Our findings indicated that the compared with nonpregnant women, pregnant women in this study did not have significantly different symptoms and were not at increased risk of complications from pandemic influenza virus infection.
authors.affiliation: Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia.
authors.forename: María Morales
authors.initials: MM
authors.lastname: Suárez-Varela
authors.forename: Fernando
authors.initials: F
authors.lastname: González-Candelas
authors.forename: Jenaro
authors.initials: J
authors.lastname: Astray
authors.forename: Jordi
authors.initials: J
authors.lastname: Alonso
authors.forename: Olatz
authors.initials: O
authors.lastname: Garin
authors.forename: Ady
authors.initials: A
authors.lastname: Castro
authors.forename: Juan C
authors.initials: JC
authors.lastname: Galán
authors.forename: Maretva
authors.initials: M
authors.lastname: Baricot
authors.forename: Jesús
authors.initials: J
authors.lastname: Castilla
authors.forename: Pere
authors.initials: P
authors.lastname: Godoy
authors.forename: Miguel
authors.initials: M
authors.lastname: Delgado-Rodríguez
authors.forename: Vicente
authors.initials: V
authors.lastname: Martin
authors.forename: José M
authors.initials: JM
authors.lastname: Mayoral
authors.forename: Tomás
authors.initials: T
authors.lastname: Pumarola
authors.forename: José M
authors.initials: JM
authors.lastname: Quintana
authors.forename: Sonia
authors.initials: S
authors.lastname: Tamames
authors.forename: Agustín
authors.initials: A
authors.lastname: Llopis-González
authors.forename: Angela
authors.initials: A
authors.lastname: Dominguez
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D058873:Pandemics; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000821:virology*; D013030:Spain / Q000453:epidemiology; D055815:Young Adult