title: Altered social interactions in male juvenile cynomolgus monkeys prenatally exposed to bisphenol A.
abstract: Bisphenol A (BPA) is a widespread environmental contaminant, and humans are routinely exposed to BPA. We investigated whether prenatal exposure to BPA influences behavioral development in juvenile cynomolgus monkeys (Macaca fascicularis). Pregnant cynomolgus monkeys were implanted with subcutaneous pumps and exposed to 10μg/kg/day BPA or vehicle (control) from gestational day 20 to 132. Both BPA-exposed and control juvenile monkeys (aged 1-2years) were assessed using the peer-encounter test that was conducted to evaluate behaviors in social interaction with a same-sex, same-treatment peer. In the encounter test, prenatal BPA exposure significantly reduced environmental exploration and presenting, a gesture related to sexual reproduction, and increased visual exploration, but only in males; furthermore, it significantly reduced the typical sexual dimorphism of the aforementioned behaviors normally observed between male and female juvenile cynomolgus monkeys. This study demonstrates that prenatal BPA exposure affects behavioral development during adolescence and results in the demasculinization of key sexually dimorphic behaviors in male juvenile monkeys.
authors.affiliation: Department of Physiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, Aichi 468-8503, Japan; Department of Chemistry and Biological Science, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5258 Japan. Electronic address: taka-u@yayoi.club.ne.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Negishi
authors.affiliation: Department of Psychology, Japan Women's University, 1-1-1 Nishi-ikuta, Tama-ku, Kawasaki, Kanagawa, 214-8565, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakagami
authors.affiliation: Department of Psychology, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Kawasaki
authors.affiliation: Shin Nippon Biomedical Laboratories, Ltd. 2438 Miyanoura, Kagoshima-shi, Kagoshima 891-1394, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Nishida
authors.affiliation: Shin Nippon Biomedical Laboratories, Ltd. 2438 Miyanoura, Kagoshima-shi, Kagoshima 891-1394, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Ihara
authors.affiliation: Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu-shi, Tokyo 183-8526, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kuroda
authors.affiliation: Department of Chemistry and Biological Science, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5258 Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tashiro
authors.affiliation: Department of Psychology, Japan Women's University, 1-1-1 Nishi-ikuta, Tama-ku, Kawasaki, Kanagawa, 214-8565, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Koyama
authors.affiliation: Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D000367:Age Factors; D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012919:Social Behavior; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Cynomolgus monkey; Sexual differentiation; Social behavior