title: Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode.
abstract: A simple, inexpensive and highly sensitive electrochemical method for the determination of jatrorrhizine was developed using an electrochemically pretreated glassy carbon electrode (EPGCE). The electrochemical behavior of jatrorrhizine was systematically investigated in detail and some kinetic parameters were calculated for the first time. A reasonable reaction mechanism of jatrorrhizine on the EPGCE was also discussed and proposed, which could be a reference for the pharmacological action of jatrorrhizine in clinical study. And the first electroanalytical method of jatrorrhizine was established with a wide linear range from 7.0×10(-8) to 2.0×10(-5)mol L(-1) and a low detection limit of 5.0×10(-8)mol L(-1). The proposed method was successfully applied in determination of jatrorrhizine in pharmaceutical sample, Tinospora capillipes Gagnep (a traditional Chinese medicine), with satisfactory results.
authors.affiliation: The First Affiliated Hospital and Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Ye
authors.affiliation: The First Affiliated Hospital and Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China; School of Chemical and Material Engineering, Henan University of Urban Construction, Pingdingshan 467036, China.
authors.forename: Yinfeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital and Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wen
authors.affiliation: The First Affiliated Hospital and Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Kunjing
authors.initials: K
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital and Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China. Electronic address: yebx@zzu.edu.cn.
authors.forename: Baoxian
authors.initials: B
authors.lastname: Ye
mesh_terms: D001599:Berberine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D015203:Reproducibility of Results; D031610:Tinospora / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; C055785:jatrorrhizine; D001599:Berberine; D002244:Carbon
keywords: Determination of jatrorrhizine; Electrochemical pretreatment; Linear sweep voltammetry; Reaction mechanism