title: Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments.
abstract: Ventricular wall stress is believed to be responsible for many physical mechanisms taking place in the human heart, including ventricular remodeling, which is frequently associated with heart failure. Therefore, normalization of ventricular wall stress is the cornerstone of many existing and new treatments for heart failure. In this paper, we sought to construct reference maps of normal ventricular wall stress in humans that could be used as a target for in silico optimization studies of existing and potential new treatments for heart failure. To do so, we constructed personalized computational models of the left ventricles of five normal human subjects using magnetic resonance images and the finite-element method. These models were calibrated using left ventricular volume data extracted from magnetic resonance imaging (MRI) and validated through comparison with strain measurements from tagged MRI (950 ± 170 strain comparisons/subject). The calibrated passive material parameter values were C0 = 0.115 ± 0.008 kPa and B0 = 14.4 ± 3.18; the active material parameter value was Tmax = 143 ± 11.1 kPa. These values could serve as a reference for future construction of normal human left ventricular computational models. The differences between the predicted and the measured circumferential and longitudinal strains in each subject were 3.4 ± 6.3 and 0.5 ± 5.9%, respectively. The predicted end-diastolic and end-systolic myofiber stress fields for the five subjects were 2.21 ± 0.58 and 16.54 ± 4.73 kPa, respectively. Thus these stresses could serve as targets for in silico design of heart failure treatments.
authors.affiliation: Surgery Department, University of California at San Francisco, San Francisco, California; Marie-Curie International Outgoing Fellow, Brussels, Belgium;
authors.forename: Martin
authors.initials: M
authors.lastname: Genet
authors.affiliation: Surgery Department, University of California at San Francisco, San Francisco, California;
authors.forename: Lik Chuan
authors.initials: LC
authors.lastname: Lee
authors.affiliation: Surgery Department, University of California at San Francisco, San Francisco, California;
authors.forename: Rebecca
authors.initials: R
authors.lastname: Nguyen
authors.affiliation: Radiology and Biomedical Imaging Department, School of Medicine, University of California at San Francisco, San Francisco, California;
authors.forename: Henrik
authors.initials: H
authors.lastname: Haraldsson
authors.affiliation: Radiology and Biomedical Imaging Department, School of Medicine, University of California at San Francisco, San Francisco, California;
authors.forename: Gabriel
authors.initials: G
authors.lastname: Acevedo-Bolton
authors.affiliation: Veterans Affairs Medical Center, San Francisco, California; and.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Veterans Affairs Medical Center, San Francisco, California; and.
authors.forename: Liang
authors.initials: L
authors.lastname: Ge
authors.affiliation: Radiology and Biomedical Imaging Department, School of Medicine, University of California at San Francisco, San Francisco, California;
authors.forename: Karen
authors.initials: K
authors.lastname: Ordovas
authors.affiliation: Institute for Biomedical Engineering, University and ETH, Zürich, Switzerland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.affiliation: Surgery Department, University of California at San Francisco, San Francisco, California; julius.guccione@ucsfmedctr.org.
authors.forename: Julius M
authors.initials: JM
authors.lastname: Guccione
mesh_terms: D003971:Diastole / Q000502:physiology; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008955:Models, Cardiovascular; D009210:Myofibrils / Q000502:physiology*; D013599:Systole / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology
keywords: computational modeling; normal human subjects; patient-specific modeling; tagged MRI