title: Polyphenol Conjugates and Human Health: A Perspective Review.
abstract: In recent years, antioxidants have gained great importance because of their potential use in food, pharmaceutical, and cosmetic industries. This interest is rooted in the cumulative evidence connecting active oxygen and free radicals with numerous human degenerative disorders, such as cardiovascular diseases, cancer, aging, and atherosclerosis. Polyphenols are the major class of antioxidant able to reduce the oxidative damages of lipids, proteins, enzymes, carbohydrates, and DNA in living cells and tissues. Among the realm of polyphenol compounds, polyphenol conjugates have been proposed as innovative materials which, by combining the advantageous properties of both the components, can increase the efficiency of antioxidants and their range of application in nutritional and biomedical fields. This work is an overview of the different class of polyphenol conjugates, which will be analyzed in terms of nutritional and biological properties, showing how these bio-conjugates will positively affect the human health.
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cirillo
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Curcio
authors.affiliation: b Children's Cancer Institute Australia, Lowy Cancer Research Centre, and Australian Centre for NanoMedicine, University of New South Wales , NSW , Australia.
authors.forename: Orazio
authors.initials: O
authors.lastname: Vittorio
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Iemma
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Restuccia
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Umile Gianfranco
authors.initials: UG
authors.lastname: Spizzirri
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Puoci
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende ( CS ), Italy.
authors.forename: Nevio
authors.initials: N
authors.lastname: Picci
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D005504:Food Analysis; D006801:Humans; D010944:Plants / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D059808:Polyphenols
keywords: Polyphenols; bio-conjugates; biological properties; nanomaterials; polymers