title: Worldwide incidence of cervical lesions: a systematic review.
abstract: We conducted a systematic review summarizing data on incidence of high- and low-grade lesions in women with normal baseline cervical cytology, stratified by age (<30 and ⩾30 years), and baseline human papillomavirus (HPV) infection. Incidence of high- and low-grade lesions in women aged ⩾30 years with a baseline HPV infection increased over follow-up time (5-127 months), although incidence generally remained <10%. Without baseline HPV infection, incidence of high-grade lesions remained low over follow-up time (<5% over 5-122 months). Incidence of high-grade lesions in women aged ⩾30 years with baseline HPV infection appeared similar to that in women aged <30 years. In some women aged <30 years, high-grade lesions can develop relatively shortly after initial HPV infection. We observed an increase in low-grade lesions over time in women aged ⩾30 years with baseline HPV infection, potentially indicative of an HPV infection that is potentially progressing to higher grade lesions.
authors.affiliation: Department of Clinical Pharmacy,University of California,San Francisco, CA,USA.
authors.forename: J
authors.initials: J
authors.lastname: Ting
authors.affiliation: Department of Epidemiology,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
authors.forename: A F
authors.initials: AF
authors.lastname: Rositch
authors.affiliation: GlaxoSmithKline Vaccines,Global Vaccine Development,Wavre,Belgium.
authors.forename: S M
authors.initials: SM
authors.lastname: Taylor
authors.affiliation: Department of Obstetrics & Gynecology,University of North Carolina at Chapel Hill,NC,USA.
authors.forename: L
authors.initials: L
authors.lastname: Rahangdale
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health,University of North Carolina at Chapel Hill,NC,USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Soeters
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health,University of North Carolina at Chapel Hill,NC,USA.
authors.forename: X
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health,University of North Carolina at Chapel Hill,NC,USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult