title: CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population.
abstract: BACKGROUND
  To explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population.
  
  
  METHODS
  We selected 440 CHD patients and 440 control subjects to perform a case - control study. Four SNPs (rs2108622, rs3093100, rs3093105 and rs3093135) in CYP4F2 gene were genotyped using polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) methods. The genotype and haplotype distributions were compared between the case and the control group.
  
  
  RESULTS
  We found both rs2108622 and rs3093105 in CYP4F2 gene were associated with the risk for CHD (P <0.01). Haplotype analysis indicated that GGGT haplotype consisted by rs2108622-rs3093100-rs3093105-rs3093135 was associated with CHD risk (OR = 4.367, 95% CI: 2.241 ~ 8.510; P < 0.001), but GGTA haplotype was associated with decreased risk for CHD (OR = 0.450, 95% CI: 0.111 ~ 0.777; P <0.001).
  
  
  CONCLUSIONS
  CYP4F2 gene polymorphisms were associated with the risk of CHD in Chinese population.
authors.forename: Changqing
authors.initials: C
authors.lastname: Yu
authors.forename: Qingkai
authors.initials: Q
authors.lastname: Yan
authors.forename: Chunjiang
authors.initials: C
authors.lastname: Fu
authors.forename: Weibin
authors.initials: W
authors.lastname: Shi
authors.forename: Hongyong
authors.initials: H
authors.lastname: Wang
authors.forename: Chunyu
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Department of Cardiology, Daping Hospital, The Third Military Medical University, 10#Changjiangzhilu, Yuzhong District, Chongqing 400042, People's Republic of China. wangxk_008@126.com.
authors.forename: Xukai
authors.initials: X
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human