title: Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.
abstract: Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, NY; and.
authors.forename: Richard J
authors.identifier: http://orcid.org/0000-0002-0834-7880
authors.initials: RJ
authors.lastname: Lin
authors.affiliation: Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Vahid
authors.initials: V
authors.lastname: Afshar-Kharghan
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, NY; and.
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Schafer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D058990:Molecular Targeted Therapy; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D013922:Thrombocytosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents