title: Hepatitis C virus-associated neuropathy accompanied by eosinophilic vasculitis and granuloma formation.
abstract: We herein report the case of a patient with hepatitis C virus (HCV)-associated neuropathy with atypical pathological findings of a biopsied sural nerve. A 48-year-old man was admitted for a gait disturbance. Purpura and edema on the legs and hyperalgesia on the distal extremities were noted. The plasma HCV viral load was high, and cryoglobulin was positive. In the biopsied sural nerve, perivascular eosinophilic infiltration was associated with extravascular granuloma formation in the epineurium. The patient's symptoms disappeared following treatment with interferon-α and ribavirin. The present case suggests that HCV infection can lead to peripheral neuropathy associated with eosinophilic infiltration and granuloma formation.
authors.affiliation: Department of Neurology, National Hospital Organization Maizuru Medical Center, Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Yuki
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshioka
authors.forename: Rei
authors.initials: R
authors.lastname: Yasuda
authors.forename: Takuma
authors.initials: T
authors.lastname: Ohmichi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Oka
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004802:Eosinophilia / Q000209:etiology; D006099:Granuloma / Q000150:complications; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D011693:Purpura / Q000209:etiology; D012254:Ribavirin / Q000627:therapeutic use; D013497:Sural Nerve / Q000473:pathology*; D014657:Vasculitis / Q000209:etiology*; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin