title: Primary cilia in pancreatic development and disease.
abstract: Primary cilia and their anchoring basal bodies are important regulators of a growing list of signaling pathways. Consequently, dysfunction in proteins associated with these structures results in perturbation of the development and function of a spectrum of tissue and cell types. Here, we review the role of cilia in mediating the development and function of the pancreas. We focus on ciliary regulation of major pathways involved in pancreatic development, including Shh, Wnt, TGF-β, Notch, and fibroblast growth factor. We also discuss pancreatic phenotypes associated with ciliary dysfunction, including pancreatic cysts and defects in glucose homeostasis, and explore the potential role of cilia in such defects.
authors.affiliation: Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Sukanya
authors.initials: S
authors.lastname: Lodh
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: O'Hare
authors.forename: Norann A
authors.initials: NA
authors.lastname: Zaghloul
mesh_terms: D000818:Animals; D002923:Cilia / Q000473:pathology*; D004195:Disease Models, Animal; D044882:Glucose Metabolism Disorders / Q000235:genetics / Q000473:pathology; D006801:Humans; D038081:Organogenesis / Q000235:genetics*; D010179:Pancreas / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D010181:Pancreatic Cyst / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D015398:Signal Transduction
keywords: FGF; Notch; Shh; TGF-beta; Wnt; cilia; ciliopathies; development; glucose homeostasis; pancreas; pancreatic cysts