title: Cross-talk between imprinted loci in Prader-Willi syndrome.
abstract: Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important implications for the understanding of imprinted gene networks.
authors.affiliation: Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Bath, UK.
authors.forename: Adele
authors.initials: A
authors.lastname: Murrell
mesh_terms: D002135:Calcium-Binding Proteins; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D007453:Iodide Peroxidase / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D011218:Prader-Willi Syndrome / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D022661:RNA, Untranslated; C117274:iodothyronine deiodinase type III; D007453:Iodide Peroxidase