title: Highly sensitive and selective fluorescence detection of copper (II) ion based on multi-ligand metal chelation.
abstract: A fluorescent probe was synthesized and demonstrated to be highly selective and sensitive in the reaction with copper (II) ion, generating a large variation of the fluorescence intensity in a dose-response manner. The probe contains a dansyl moiety as fluorophore and a multidentate ligand for copper (II) ion recognition. The reaction of the molecular probe with copper (II) ion proceeds rapidly and irreversibly in a 1 to 1 stoichiometric way, leading to the production of stable copper (II) complex, which subsequently results in the quenching of fluorescence. The detection limit for copper (II) ion was measured to be about 2ppb. It was also shown that the probe has high selectivity for copper (II) ion and good anti-interference ability against other transition metal ions. The herein reported very simple and reliable fluorescence probe could be employed for copper (II) ion detection in many aspects.
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, People׳s Republic of China; Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, People׳s Republic of China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Pharmaceutical Chemistry, State Key Laboratory of NBC Protection for Civilian, Beijing 102205, People׳s Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, People׳s Republic of China.
authors.forename: Mingtai
authors.initials: M
authors.lastname: Sun
authors.affiliation: Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, People׳s Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, People׳s Republic of China; Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, People׳s Republic of China.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, People׳s Republic of China; Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, People׳s Republic of China. Electronic address: shwang@iim.ac.cn.
authors.forename: Suhua
authors.initials: S
authors.lastname: Wang
authors.affiliation: Beijing Institute of Pharmaceutical Chemistry, State Key Laboratory of NBC Protection for Civilian, Beijing 102205, People׳s Republic of China. Electronic address: jiangtide@sina.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
mesh_terms: D003300:Copper / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008670:Metals / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D008956:Models, Chemical; D015394:Molecular Structure; D015203:Reproducibility of Results; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014867:Water / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands; D008670:Metals; D014867:Water; D003300:Copper
keywords: Coordination; Copper (II) ion; Dansyl-based fluorescent probe