title: No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: evidence from a meta-analysis.
abstract: OBJECTIVE
  To clarify the associations between G-protein beta polypeptide 3 (GNB3) C825T polymorphism and risk of the irritable bowel syndrome (IBS) by a meta-analysis.
  
  
  METHODS
  We searched relevant studies in PubMed, EMBASE, CNKI, Google Scholar, Ovid and Cochrane library prior to October 2013. The strengths of the associations between GNB3 C825T polymorphism and IBS risk were estimated by odds ratios (ORs) with 95% confidence interval (CIs).
  
  
  RESULTS
  We identified seven case-control studies with 1085 IBS cases and 1695 controls for the analysis. We found no significantly associations of GNB3 C825T polymorphism with IBS risk in the overall population (CC vs TT, OR = 1.12, 95%CI: 0.86-1.45; CC + CT vs TT, OR = 1.17, 95%CI: 0.92-1.49; TT + CT vs CC, OR = 0.93, 95%CI: 0.80-1.08; C vs T, OR = 1.08, 95%CI: 0.97-1.21). Subgroup analysis did not reveal significant associations either in Asian population or Caucasian population. The pooled results of four studies fail to show associations of GNB3 C825T polymorphism with subtypes of IBS (constipation-dominant type, diarrhea-dominant type and mixed type).
  
  
  CONCLUSIONS
  The present study suggests no associations of GNB3 C825T polymorphism with IBS risk.
authors.affiliation: Zhi-Gang Pan, Chen Xiao, Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Pan
authors.affiliation: Zhi-Gang Pan, Chen Xiao, Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Zhi-Gang Pan, Chen Xiao, Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China.
authors.forename: Dong-Xing
authors.initials: DX
authors.lastname: Su
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins
keywords: G-protein beta polypeptide 3; Irritable bowel syndrome; Meta-analysis; Polymorphisms