title: Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars.
abstract: OBJECTIVE
  The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications.
  
  
  METHODS
  The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake.
  
  
  RESULTS
  From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences between the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications (p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication.
  
  
  CONCLUSIONS
  The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort.
authors.affiliation: Facultad de Odontología de Sevilla, C/ Avicena s/n 41009, Sevilla (SPAIN), danieltl@us.es.
authors.forename: Fernando
authors.initials: F
authors.lastname: Iglesias-Martín
authors.forename: Alberto
authors.initials: A
authors.lastname: García-Perla-García
authors.forename: Rosa
authors.initials: R
authors.lastname: Yañez-Vico
authors.forename: Elena
authors.initials: E
authors.lastname: Aced-Jiménez
authors.forename: Esther
authors.initials: E
authors.lastname: Arjona-Gerveno
authors.forename: Juan-David
authors.initials: JD
authors.lastname: González-Padilla
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Gutierrez-Pérez
authors.forename: Daniel
authors.initials: D
authors.lastname: Torres-Lagares
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D014081:Tooth Extraction; D065093:beta-Lactamase Inhibitors / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin