title: Overexpression of IL-17RC associated with ocular sarcoidosis.
abstract: BACKGROUND
  Sarcoidosis is a chronic inflammatory disease with a systemic granulomatous disorder affecting multiple organs including the eye. Both CD4+ T cell and macrophage have been linked to the pathogenesis of the disease.
  
  
  METHODS
  The expression of IL-17RC was measured using FACS,immunohistochemistry and real-time PCR. Serum level of IL-17 was detected using ELISA.
  
  
  RESULTS
  An elevated expression of IL-17RC on CD8+ T cells in peripheral blood was found in patients with ocular sarcoidosis as compared to healthy controls. Interestingly, we found a significant increase in the serum level of IL-17 in patients with ocular sarcoidosis as compared to healthy controls, which may be responsible for the induction of IL-17RC on CD8+ cells. In addition, IL-17RC appeared only in the retinal tissue of the patient with clinically active sarcoidosis.
  
  
  CONCLUSIONS
  Our results suggested a potential involvement of IL-17RC+CD8+ T cells in pathogenesis of ocular sarcoidosis.
authors.forename: Wenting
authors.initials: W
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Jin
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Baoying
authors.initials: B
authors.lastname: Liu
authors.forename: Defen
authors.initials: D
authors.lastname: Shen
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Susan
authors.initials: S
authors.lastname: Hannes
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
authors.forename: Sima
authors.initials: S
authors.lastname: Hirani
authors.forename: Shayma
authors.initials: S
authors.lastname: Jawad
authors.forename: H Nida
authors.initials: HN
authors.lastname: Sen
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
authors.affiliation: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. drbob@nei.nih.gov.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005128:Eye Diseases / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D053722:Receptors, Interleukin-17 / Q000378:metabolism*; D012507:Sarcoidosis / Q000378:metabolism*
chemical_list: D053722:Receptors, Interleukin-17