title: Interferon regulatory factor 3 in adaptive immune responses.
abstract: Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells. Recent evidences indicate that this pathway also modulates adaptive immune responses. This review focuses on the different mechanisms that are implicated in this process. We discuss the role of IRF3 within antigen-presenting cells and T lymphocytes in the polarization of the cellular immune response and its implication in the pathogenesis of immune disorders.
authors.affiliation: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles, 8 rue Adrienne Bolland, 6041, Charleroi-Gosselies, Belgium.
authors.forename: Laure
authors.initials: L
authors.lastname: Ysebrant de Lendonck
authors.forename: Valerie
authors.initials: V
authors.lastname: Martinet
authors.forename: Stanislas
authors.initials: S
authors.lastname: Goriely
mesh_terms: D056704:Adaptive Immunity; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D050838:Interferon Regulatory Factor-3 / Q000378:metabolism*; D007370:Interferon Type I / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D007370:Interferon Type I; D051193:Toll-Like Receptors