title: [Mycolic acids--biological role and potential application in Mycobacterium detection and differentiation].
abstract: Mycolic acids are one of the basic structural elements of the cell wall of bacteria from Corynebacterineae suborder. These compounds are long-chain α-hydroxy β-alkyl fatty acids with two hydrocarbon chains: longer meromycolic and shorter α-chain meromycolic α-chain. The genus Mycobacterium is characterized by the presence of mycolic acids in length from 60 to 90 carbon atoms having a fully saturated α-chain with a defined length of 22, 24 or 26 carbon atoms. Current research indicates that not only the presence of mycolic acids in the cell wall of mycobacteria is essential for the virulence of mycobacteria. It is proved that the relationship between different types of mycolic acids, their length and the degree of cyclopropanation may vary depending on the stage of infection and mycobacterial culture conditions. At the same time it has been shown that some mycolic acid types are crucial for biofilm formation, antimycobacterial drug resistance or interactions with the immune system. Recent studies also indicate that analysis of mycolic acid profiles could be an alternative to conventional methods of diagnosis of diseases such as tuberculosis, leprosy or mycobacteriosis.
authors.affiliation: Laboratorium Chemii Biomedycznej, Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu.
authors.forename: Konrad
authors.initials: K
authors.lastname: Kowalski
authors.affiliation: Zakład Immunologii Komórkowej, Katedra Immunologii i Biologii Infekcyjnej, Instytut Mikrobiologii, Biotechnologii i Immunologii, Uniwersytet Łódzki.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Trzepiński
authors.affiliation: Zakład Immunologii Komórkowej, Katedra Immunologii i Biologii Infekcyjnej, Instytut Mikrobiologii, Biotechnologii i Immunologii, Uniwersytet Łódzki.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Druszczyńska
authors.affiliation: Laboratorium Chemii Biomedycznej, Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wro.
authors.forename: Janusz
authors.initials: J
authors.lastname: Boratyński
mesh_terms: D018441:Biofilms / Q000254:growth & development; D002473:Cell Wall / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D009161:Mycobacterium / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D009171:Mycolic Acids / Q000032:analysis / Q000378:metabolism*; D014774:Virulence / Q000502:physiology
chemical_list: D005227:Fatty Acids; D009171:Mycolic Acids