title: Three new cyclopentenone derivatives from Actinoalloteichus nanshanensis NEAU 119.
abstract: Three new cyclopentenone derivatives (1-3) were isolated from the rare actinomycete Actinoalloteichus nanshanensis NEAU 119. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 showed moderate cytotoxic activity against human lung adenocarcinoma cell line A549, human leukemia cell line K562, and human renal carcinoma cell line ACHN with an IC50 of 14.67, 11.87, and 23.36 μg ml(-1), respectively.
authors.affiliation: a Key Laboratory of Agriculture Biological Functional Gene of Heilongjiang Provincial Education Committee, Northeast Agricultural University , Harbin 150030 , China.
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Qian
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Liu
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000230:Adenocarcinoma / Q000188:drug therapy; D000077192:Adenocarcinoma of Lung; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D030681:Ficus / Q000382:microbiology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D058441:Rhizosphere
chemical_list: D000970:Antineoplastic Agents; D003517:Cyclopentanes; C013905:cyclopentenone
keywords: Actinoalloteichus nanshanensis NEAU 119; cyclopentenone; cytotoxic activity