title: Influence of hyperhomocysteinemia on left ventricular diastolic function in Chinese patients with hypertension.
abstract: OBJECTIVE
  The aim of this study was to assess the effect of plasma homocysteine (Hcy) on left ventricular (LV) diastolic function in Chinese patients with essential hypertension.
  
  
  METHODS
  A total of 74 patients with hypertension were enrolled in the present study and were divided into two groups according to the plasma levels of Hcy: high levels of Hcy (Hhcy) group (n = 37) and control group (n = 37) with normal levels of homocysteine. The study participants consisted of 37 hypertensive patients with Hhcy and 37 hypertensive patients without Hhcy. Transthoracic Doppler echocardiography was performed to assess the LV diastolic function of the patients.
  
  
  RESULTS
  The plasma level of Hcy was directly related to LV diastolic echocardiographic parameters in patients with hypertension whereby the ratio E/e' was higher (12.7 ± 2.64 vs. 8.98 ± 1.55, p < 0.01), e'/a' was lower (0.59 ± 0.13 vs. 0.83 ± 0.20, p < 0.01), and the left atrial (LA) diameter was longer (43.4 ± 3.6 mm vs. 37.6 ± 5.0 mm, p < 0.01) in the Hhcy group than in the control group.
  
  
  CONCLUSIONS
  The LV diastolic function was significantly deteriorated in Chinese hypertensive patients with Hhcy and there were significant correlations between LV diastolic function indices and Hcy levels.
authors.affiliation: Department of Cardiology, Tongji Hospital, Tongji University, No. 389 Xincun Road, 200065, Shanghai, China.
authors.forename: L
authors.initials: L
authors.lastname: Ruhui
authors.forename: J
authors.initials: J
authors.lastname: Jinfa
authors.forename: X
authors.initials: X
authors.lastname: Jiahong
authors.forename: M
authors.initials: M
authors.lastname: Wenlin
mesh_terms: D015415:Biomarkers / Q000097:blood; D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D015415:Biomarkers; D006710:Homocysteine