title: [Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease].
abstract: Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease.
  
  
  BACKGROUND
  We describe two cases of immunocompetent patients with chronic obstructive pulmonary disease (COPD) who developed severe cytomegalovirus (CMV) pneumonia. The clinical and radiological context and CMV replication in broncho-alveolar lavage suggested a diagnosis of CMV pneumonia.
  
  
  METHODS
  We report two cases in patients with moderate chronic obstructive pulmonary disease not treated with long-term steroid therapy who developed bilateral pneumonia with hypoxaemia. The only pathogen identified was CMV with replication of the virus in the broncho-alveolar lavage. Investigation failed to detect any associated immune deficiency.
  
  
  CONCLUSIONS
  Severe cytomegalovirus pneumonia could be encouraged by the existence of chronic obstructive pulmonary disease due to local inflammatory changes.
authors.affiliation: Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France. Electronic address: CBosc1@chu-grenoble.fr.
authors.forename: C
authors.initials: C
authors.lastname: Bosc
authors.affiliation: Service de pneumologie et d'oncologie thoracique, centre hospitalier de Chambéry, 73000 Chambéry, France.
authors.forename: M
authors.initials: M
authors.lastname: Clement
authors.affiliation: Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France; Service de pneumologie et d'oncologie thoracique, centre hospitalier de Chambéry, 73000 Chambéry, France.
authors.forename: A
authors.initials: A
authors.lastname: Deroux
authors.affiliation: Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France.
authors.forename: A
authors.initials: A
authors.lastname: Mammar
authors.affiliation: Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France.
authors.forename: C
authors.initials: C
authors.lastname: Pison
authors.affiliation: Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France.
authors.forename: B
authors.initials: B
authors.lastname: Camara
mesh_terms: D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000276:immunology / Q000821:virology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000276:immunology / Q000821:virology; D012720:Severity of Illness Index
keywords: Broncho-pneumopathie chronique obstructive (BPCO); Chronic obstructive pulmonary disease; Cytomegalovirus; Cytomégalovirus (CMV); Immunocompetence; Immunocompétence; Inflammation; Pneumonia; Pneumopathie; TNF-alpha