title: Severe leukopenia in a rheumatoid arthritis patient treated with a methotrexate/leflunomide combination.
abstract: A rheumatoid arthritis patient was treated for two years with methotrexate and leflunomide combination therapy. The evolution was uneventful until she had clopidogrel, simvastatin, isosorbide, aspirin and omeprazole added to medication due to acute myocardial infarction. Four weeks after this, she was hospitalized with severe leukopenia.
authors.forename: Paola
authors.initials: P
authors.lastname: Toth
authors.forename: Roberto
authors.initials: R
authors.lastname: Bernd
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects*; D000077339:Leflunomide; D007970:Leukopenia / Q000139:chemically induced*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D018501:Antirheumatic Agents; D004338:Drug Combinations; D007555:Isoxazoles; D000077339:Leflunomide; D008727:Methotrexate