title: Clinical outcome of adult choroid plexus tumors: retrospective analysis of a single institute.
abstract: BACKGROUND
  Choroid plexus tumors are rare brain tumors with clinical features that vary according to the histological grade. We reviewed the treatment outcomes of 15 adult patients with choroid plexus tumors, focusing on surgical outcomes and current therapeutic strategies.
  
  
  METHODS
  Patient demographic and clinical characteristics, operative findings, adjuvant therapies, disease progression and survival rates were reviewed.
  
  
  RESULTS
  The median age at diagnosis was 33.7 ± 10 years (19-59 years) for patients with choroid plexus tumors. Postoperative chemotherapy was given to 26.7 % of patients, and 13.3 % of patients received radiotherapy. The Ki-67 labeling index and mitotic index increased at higher histological grades. All of the choroid plexus papilloma and atypical choroid plexus papilloma patients have survived. The overall survival rate of patients with choroid plexus carcinoma was 50 % in the first year, but none of the patients survived to the second year. Five patients underwent permanent cerebrospinal fluid diversion surgery because of hydrocephalus or subdural effusion.
  
  
  CONCLUSIONS
  Choroid plexus papilloma and atypical choroid plexus papilloma patients can be treated with complete surgical resection. Choroid plexus carcinoma has a poor prognosis, and aggressive multi-modal treatments are generally needed for treatment. Chemotherapy and radiotherapy are important adjuvant therapies for choroid plexus carcinoma. If hydrocephalus and/or subdural effusion occur, permanent cerebrospinal fluid (CSF) diversion should be added to the therapeutic strategy.
authors.affiliation: Neurosurgery Clinic, Ministry of Health, Diskapi Yildirim Beyazit Research and Educational Hospital, 06610, Ankara, Turkey, drmet122@yahoo.com.
authors.forename: Erhan
authors.initials: E
authors.lastname: Turkoglu
authors.forename: Hayri
authors.initials: H
authors.lastname: Kertmen
authors.forename: Ahmet Metin
authors.initials: AM
authors.lastname: Sanli
authors.forename: Evrim
authors.initials: E
authors.lastname: Onder
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gunaydin
authors.forename: Levent
authors.initials: L
authors.lastname: Gurses
authors.forename: Behzat R
authors.initials: BR
authors.lastname: Ergun
authors.forename: Zeki
authors.initials: Z
authors.lastname: Sekerci
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D016545:Choroid Plexus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult