title: The functional diversity of essential genes required for mammalian cardiac development.
abstract: Genes required for an organism to develop to maturity (for which no other gene can compensate) are considered essential. The continuing functional annotation of the mouse genome has enabled the identification of many essential genes required for specific developmental processes including cardiac development. Patterns are now emerging regarding the functional nature of genes required at specific points throughout gestation. Essential genes required for development beyond cardiac progenitor cell migration and induction include a small and functionally homogenous group encoding transcription factors, ligands and receptors. Actions of core cardiogenic transcription factors from the Gata, Nkx, Mef, Hand, and Tbx families trigger a marked expansion in the functional diversity of essential genes from midgestation onwards. As the embryo grows in size and complexity, genes required to maintain a functional heartbeat and to provide muscular strength and regulate blood flow are well represented. These essential genes regulate further specialization and polarization of cell types along with proliferative, migratory, adhesive, contractile, and structural processes. The identification of patterns regarding the functional nature of essential genes across numerous developmental systems may aid prediction of further essential genes and those important to development and/or progression of disease.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, United Kingdom.
authors.forename: Christopher
authors.initials: C
authors.lastname: Clowes
authors.forename: Michael G S
authors.initials: MG
authors.lastname: Boylan
authors.forename: Liam A
authors.initials: LA
authors.lastname: Ridge
authors.forename: Emma
authors.initials: E
authors.lastname: Barnes
authors.forename: Jayne A
authors.initials: JA
authors.lastname: Wright
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Hentges
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D020043:Genes, Essential / Q000235:genetics*; D006321:Heart / Q000196:embryology / Q000254:growth & development*; D008322:Mammals / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D051379:Mice; D013234:Stem Cells
keywords: cardiac chamber specification; epicardium; heart; heart fields; sarcomere; trabeculation