title: Cell membrane tracker based on restriction of intramolecular rotation.
abstract: The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed significant RIR characteristics. When cells were incubated with TR4, cytoplasmic membranes were specifically labeled. TR4 shows excellent photostability and low cytotoxicity.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology , No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Zhang
authors.forename: Shubin
authors.initials: S
authors.lastname: Jin
authors.forename: Keni
authors.initials: K
authors.lastname: Yang
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Xue
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Li
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Chen
authors.forename: Luru
authors.initials: L
authors.lastname: Dai
authors.forename: Guozhang
authors.initials: G
authors.lastname: Zou
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D002118:Calcium / Q000737:chemistry; D002462:Cell Membrane / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry; D005453:Fluorescence; D008081:Liposomes / Q000737:chemistry; D019308:Palmitic Acid / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
chemical_list: D005030:Ethylenes; D008081:Liposomes; D010455:Peptides; D019308:Palmitic Acid; D002118:Calcium