title: Glucose sensing by waveguide-based absorption spectroscopy on a silicon chip.
abstract: In this work, we demonstrate in vitro detection of glucose by means of a lab-on-chip absorption spectroscopy approach. This optical method allows label-free and specific detection of glucose. We show glucose detection in aqueous glucose solutions in the clinically relevant concentration range with a silicon-based optofluidic chip. The sample interface is a spiral-shaped rib waveguide integrated on a silicon-on-insulator (SOI) photonic chip. This SOI chip is combined with micro-fluidics in poly(dimethylsiloxane) (PDMS). We apply aqueous glucose solutions with different concentrations and monitor continuously how the transmission spectrum changes due to glucose. Based on these measurements, we derived a linear regression model, to relate the measured glucose spectra with concentration with an error-of-fitting of only 1.14 mM. This paper explains the challenges involved and discusses the optimal configuration for on-chip evanescent absorption spectroscopy. In addition, the prospects for using this sensor for glucose detection in complex physiological media (e.g. serum) is briefly discussed.
authors.affiliation: Photonics Research Group, INTEC Department, Ghent University - IMEC, Sint-Pietersnieuwstraat 41,9000 Ghent, Belgium ; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Ryckeboer
authors.affiliation: Photonics Research Group, INTEC Department, Ghent University - IMEC, Sint-Pietersnieuwstraat 41,9000 Ghent, Belgium ; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Bockstaele
authors.affiliation: Photonics Research Group, INTEC Department, Ghent University - IMEC, Sint-Pietersnieuwstraat 41,9000 Ghent, Belgium ; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Vanslembrouck
authors.affiliation: Photonics Research Group, INTEC Department, Ghent University - IMEC, Sint-Pietersnieuwstraat 41,9000 Ghent, Belgium ; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Baets
keywords: (250.5300) Photonic integrated circuits; (280.1415) Biological sensing and sensors; (300.1030) Absorption