title: Multifunctional tunable p(inulin) microgels.
abstract: Inulin, inulin-silica and modified inulin microgels were prepared in a single step via crosslinking within microemulsion, and used as drug delivery devices. Inulin-silica composite micro particles were also synthesized in the presence of tetraethyl orthosilicate (TEOS) via a water-in-oil microemulsion polymerization/crosslinking technique. To generate porous inulin particles, inulin-silica particles were treated with 0.5M NaOH solution to dissolve silica particles. Furthermore, virgin inulin (p(inulin)) and porous inulin microgels (por-p(inulin)) were quaternized successfully by treatment with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTMAC) in aqueous solution, generating positive charges on the biopolymer as q-p(inulin). Rosmarinic acid (RA) was used as model drug for loading and release studies by synthesized inulin-based microgels in phosphate buffer solution (PBS) at pH7.4. It was shown that the absorption and release rate are influenced by zeta potential and porosity of the microgels.
authors.affiliation: Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey; Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey. Electronic address: sahiner71@gmail.com.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Sahiner
authors.affiliation: Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.
authors.forename: Selin
authors.initials: S
authors.lastname: Sagbas
mesh_terms: D000327:Adsorption; D002934:Cinnamates / Q000737:chemistry / Q000378:metabolism; D053630:Depsides / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels / Q000138:chemical synthesis / Q000737:chemistry*; D007444:Inulin / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D000097123:Rosmarinic Acid
chemical_list: D002934:Cinnamates; D053630:Depsides; D004337:Drug Carriers; D005782:Gels; D007444:Inulin; D009584:Nitrogen; D012822:Silicon Dioxide; D000097123:Rosmarinic Acid
keywords: Modified inulin microgel/nanogel; Natural polymeric microgel; P(inulin) microgel; Porous p(inulin) microgel