title: [Rational polytherapy of epilepsy in children].
abstract: About 30% of patients with epilepsy are resistant to pharmacological treatment. These patients benefit from combinational therapy with two or more antiepileptic drugs (AEDs). The management of resistant epileptic patients with AEDs combinations is based on the pharmacokinetic and pharmacodynamic interactions between AEDs. The article reviews the data on interactions between widely used AEDs.
authors.affiliation: FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut pediatrii i detskoĭ khirurgii Minzdrava Rossii, Moskva.
authors.forename: E D
authors.initials: ED
authors.lastname: Belousova