title: Aligned porous barium titanate/hydroxyapatite composites with high piezoelectric coefficients for bone tissue engineering.
abstract: It was proposed that the piezoelectric effect played an important physiological role in bone growth, remodelling and fracture healing. An aligned porous piezoelectric composite scaffold was fabricated by freeze casting hydroxyapatite/barium titanate (HA/BT) suspensions. The highest compressive strength and lowest porosity of 14.5MPa and 57.4% with the best parallelism of the pore channels were achieved in the HA10/BT90 composite. HA30/BT70 and HA10/BT90 composites exhibited piezoelectric coefficient d33 of 1.2 and 2.8pC/N, respectively, both of which were higher than the piezoelectric coefficient of natural bone. Increase of the solid loading of the suspension and solidification velocity led to the improvement of piezoelectric coefficient d33. Meanwhile, double-templates resulted in the coexistence of lamellar pores and aligned macro-pores, exhibiting the ability to produce an oriented long-range ordered architecture. The manipulation flexibility of this method indicated the potential for customized needs in the application of bone substitute. An MTT assay indicated that the obtained scaffolds had no cytotoxic effects on L929 cells.
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, PR China.
authors.forename: Liangjian
authors.initials: L
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, 410083, PR China.
authors.forename: Kechao
authors.initials: K
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, 410083, PR China. Electronic address: dzhang@csu.edu.cn.
authors.forename: Dou
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017609:Barium Compounds / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000737:chemistry*; D002460:Cell Line; D019245:Compressive Strength; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006882:Hydroxyapatites / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D017609:Barium Compounds; D001672:Biocompatible Materials; D018786:Bone Substitutes; D006882:Hydroxyapatites; C041297:barium hydroxyapatite
keywords: Aligned structures; Biomedical application; Directional solidification; Hydroxyapatite/barium titanate; Piezoelectric ceramics; Porous material