title: Sequential gastroenteritis episodes caused by 2 norovirus genotypes.
abstract: We investigated sequential episodes of acute norovirus gastroenteritis in a young child within an 11-month period. The infections were caused by 2 distinct genotypes (GII.4 and GII.6). Failure to achieve cross-protective immunity was linked to absence of an enduring and cross-reactive mucosal immune response, a critical consideration for vaccine design.
authors.forename: Gabriel I
authors.initials: GI
authors.lastname: Parra
authors.forename: Kim Y
authors.initials: KY
authors.lastname: Green
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D017250:Caliciviridae Infections / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D005838:Genotype; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000097:blood; D007223:Infant; D029322:Norovirus / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D012367:RNA, Viral; D015678:Viral Structural Proteins
keywords: Norovirus; diarrhea; genotype; immunity; viruses