title: Effect of pregabalin and dexamethasone on postoperative analgesia after septoplasty.
abstract: Objectives. The aim of this study was to explore effect of a combination of pregabalin and dexamethasone on pain control after septoplasty operations. Methods. In this study, 90 patients who were scheduled for septoplasty under general anesthesia were randomly assigned into groups that received either placebo (Group C), pregabalin (Group P), or pregabalin and dexamethasone (Group PD). Preoperatively, patients received either pregabalin 300 mg one hour before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain treatment included tramadol and diclofenac sodium 30 minutes before the end of the operation. Numeric rating scale (NRS) for pain assessment, side effects, and consumption of tramadol, pethidine, and ondansetron were recorded. Results. The median NRS score at the postoperative 0 and the 2nd h was significantly higher in Group C than in Group P and Group PD (P ≤ 0.004 for both). The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (P < 0.001 and P < 0.001). The incidence of blurred vision was significantly higher in Group PD compared to Group C within both 0-2 h and 0-24 h periods (P = 0.002 and P < 0.001, resp.). Conclusions. We conclude that administration of 300 mg pregabalin preoperatively may be an adequate choice for pain control after septoplasty. Addition of dexamethasone does not significantly reduce pain in these patients.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Demirhan
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Akcan
authors.initials: A
authors.lastname: Akkaya
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Umit Yasar
authors.initials: UY
authors.lastname: Tekelioglu
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Apuhan
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Bilgi
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Veysel
authors.initials: V
authors.lastname: Yurttas
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Bayir
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Isa
authors.initials: I
authors.lastname: Yildiz
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Uzeyir
authors.initials: U
authors.lastname: Gok
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kocoglu