title: Tissue concentrations of estrogens and aromatase immunolocalization in interstitial pneumonia of human lung.
abstract: Interstitial pneumonia (IP) is characterized by various degrees of pulmonary fibrosis and inflammation. Estrogens have been demonstrated to play important roles in physiological and pathological conditions of human lung, but significance of estrogens has remained unknown in human IP. Therefore, we measured estrogen concentrations and immunolocalized aromatase and estrogen receptor β (ERβ) in IP tissues. Estradiol concentration was significantly (2.8-fold) higher in IP than normal lung tissues, and aromatase activity evaluated by estradiol/testosterone ratio was also significantly (7.2-fold) elevated in IP tissues. Aromatase immunoreactivity in alveolar epithelial cells was significantly frequent in IP than normal lung or inflammatory lung disease other than IP, and it was positively associated with ERβ immunoreactivity in these cells of IP. These results suggest that estradiol concentration is locally increased in human IP tissue by aromatase, and increased estrogens may play an important role in the development of IP through ERβ in the alveolar epithelial cells.
authors.affiliation: Departments of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Taniuchi
authors.affiliation: Departments of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Fujishima
authors.affiliation: Departments of Anatomic Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan; Department of Disaster Obstetrics and Gynecology, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miki
authors.affiliation: Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.affiliation: Departments of Anatomic Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Departments of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Sato
authors.affiliation: Departments of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kasajima
authors.affiliation: Department of Disaster Obstetrics and Gynecology, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
authors.forename: Misaki
authors.initials: M
authors.lastname: Fue
authors.affiliation: Division of Diagnostic Molecular Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Iwate, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ishida
authors.affiliation: Departments of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Departments of Respiratory Medicine, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakakibara
authors.affiliation: Departments of Thoracic Surgery, Tohoku University Hospital, Sendai, Japan.
authors.forename: Sumiko
authors.initials: S
authors.lastname: Maeda
authors.affiliation: Departments of Pathology and Histotechnology, Tohoku University, Graduate School of Medicine, Sendai, Japan. Electronic address: t-suzuki@patholo2.med.tohoku.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Departments of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan; Departments of Anatomic Pathology, Tohoku University, Graduate School of Medicine, Sendai, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001141:Aromatase / Q000378:metabolism*; D004847:Epithelial Cells / Q000201:enzymology; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D001141:Aromatase
keywords: Aromatase; Estrogen; Interstitial pneumonia; Lung