title: Mechanisms of adiponectin-associated perivascular function in vascular disease.
abstract: The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enough to explain disease states, such as hypertension and metabolic changes associated with obesity and type II diabetes mellitus. This ATVB in Focus intends to examine our current knowledge in this field, and suggests mechanisms that may be responsible for normal perivascular function and how they become disordered in obesity. There is the tantalizing prospect of developing new therapeutic approaches to keep obese individuals healthy and redesignating type II diabetes mellitus as a vascular disease.
authors.affiliation: From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom. sarah.withers@manchester.ac.uk.
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Withers
authors.affiliation: From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Bussey
authors.affiliation: From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Sophie N
authors.initials: SN
authors.lastname: Saxton
authors.affiliation: From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Melrose
authors.affiliation: From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Watkins
authors.affiliation: From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Heagerty
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D019899:Paracrine Communication; D012307:Risk Factors; D015398:Signal Transduction; D014652:Vascular Diseases / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D015431:Weight Loss
chemical_list: D052242:Adiponectin
keywords: adiponectin; adipose tissue; blood supply