title: Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors.
abstract: Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: Ung Yeol
authors.initials: UY
authors.lastname: Lee
authors.affiliation: Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.affiliation: Department of Biomedical Engineering, Yale University, 55 Prospect Street, 401 Malone Engineering Center, New Haven, CT 06511, USA.
authors.forename: Dongin
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea. Electronic address: eslee@catholic.ac.kr.
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002735:Chlorophyllides; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008819:Mice, Nude; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000008:administration & dosage* / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D013499:Surface Properties; D023041:Xenograft Model Antitumor Assays
chemical_list: D002735:Chlorophyllides; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D008823:Micelles; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C062985:phytochlorin
keywords: Chlorin e6 (Ce6); Grain-marked micelles; Magnetic resonance imaging; Multimeric micelles; Photodynamic therapy