title: Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial.
abstract: BACKGROUND
  Maintenance monotherapy with the PARP inhibitor olaparib significantly prolonged progression-free survival (PFS) versus placebo in patients with platinum-sensitive recurrent serous ovarian cancer. We aimed to explore the hypothesis that olaparib is most likely to benefit patients with a BRCA mutation.
  
  
  METHODS
  We present data from the second interim analysis of overall survival and a retrospective, preplanned analysis of data by BRCA mutation status from our randomised, double-blind, phase 2 study that assessed maintenance treatment with olaparib 400 mg twice daily (capsules) versus placebo in patients with platinum-sensitive recurrent serous ovarian cancer who had received two or more platinum-based regimens and who had a partial or complete response to their most recent platinum-based regimen. Randomisation was by an interactive voice response system, stratified by time to progression on penultimate platinum-based regimen, response to the most recent platinum-based regimen before randomisation, and ethnic descent. The primary endpoint was PFS, analysed for the overall population and by BRCA status. This study is registered with ClinicalTrials.gov, number NCT00753545.
  
  
  RESULTS
  Between Aug 28, 2008, and Feb 9, 2010, 136 patients were assigned to olaparib and 129 to placebo. BRCA status was known for 131 (96%) patients in the olaparib group versus 123 (95%) in the placebo group, of whom 74 (56%) versus 62 (50%) had a deleterious or suspected deleterious germline or tumour BRCA mutation. Of patients with a BRCA mutation, median PFS was significantly longer in the olaparib group than in the placebo group (11·2 months [95% CI 8·3-not calculable] vs 4·3 months [3·0-5·4]; HR 0·18 [0·10-0·31]; p<0·0001); similar findings were noted for patients with wild-type BRCA, although the difference between groups was lower (7·4 months [5·5-10·3] vs 5·5 months [3·7-5·6]; HR 0·54 [0·34-0·85]; p=0·0075). At the second interim analysis of overall survival (58% maturity), overall survival did not significantly differ between the groups (HR 0·88 [95% CI 0·64-1·21]; p=0·44); similar findings were noted for patients with mutated BRCA (HR 0·73 [0·45-1·17]; p=0·19) and wild-type BRCA (HR 0·99 [0·63-1·55]; p=0·96). The most common grade 3 or worse adverse events in the olaparib group were fatigue (in ten [7%] patients in the olaparib group vs four [3%] in the placebo group) and anaemia (seven [5%] vs one [<1%]). Serious adverse events were reported in 25 (18%) patients who received olaparib and 11 (9%) who received placebo. Tolerability was similar in patients with mutated BRCA and the overall population.
  
  
  CONCLUSIONS
  These results support the hypothesis that patients with platinum-sensitive recurrent serous ovarian cancer with a BRCA mutation have the greatest likelihood of benefiting from olaparib treatment.
  
  
  BACKGROUND
  AstraZeneca.
authors.affiliation: UCL Cancer Institute, University College London, London, UK. Electronic address: j.ledermann@ucl.ac.uk.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ledermann
authors.affiliation: Kliniken Essen Mitte, Essen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Harter
authors.affiliation: University of Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.
authors.forename: Charlie
authors.initials: C
authors.lastname: Gourley
authors.affiliation: Prince of Wales Clinical School, University of New South Wales, Randwick, NSW, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Friedlander
authors.affiliation: University of Leuven, Leuven, Belgium.
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.affiliation: Mount Vernon Hospital, Northwood, Middlesex, UK.
authors.forename: Gordon
authors.initials: G
authors.lastname: Rustin
authors.affiliation: Royal Melbourne Hospital, Parkville, NSW, Australia.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Scott
authors.affiliation: Evangelisches Krankenhaus, Düsseldorf, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Meier
authors.affiliation: Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Ronnie
authors.initials: R
authors.lastname: Shapira-Frommer
authors.affiliation: Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Tamar
authors.initials: T
authors.lastname: Safra
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Matei
authors.affiliation: AstraZeneca, Macclesfield, Cheshire, UK.
authors.forename: Anitra
authors.initials: A
authors.lastname: Fielding
authors.affiliation: AstraZeneca, Macclesfield, Cheshire, UK.
authors.forename: Stuart
authors.initials: S
authors.lastname: Spencer
authors.affiliation: AstraZeneca, Waltham, MA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Dougherty
authors.affiliation: AstraZeneca, Macclesfield, Cheshire, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Orr
authors.affiliation: AstraZeneca, Macclesfield, Cheshire, UK.
authors.forename: Darren
authors.initials: D
authors.lastname: Hodgson
authors.affiliation: AstraZeneca, Waltham, MA, USA.
authors.forename: J Carl
authors.initials: JC
authors.lastname: Barrett
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Ursula
authors.initials: U
authors.lastname: Matulonis
mesh_terms: D000368:Aged; D000740:Anemia / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D018095:Germ-Line Mutation; D006801:Humans; D060046:Maintenance Chemotherapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000235:genetics; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000188:drug therapy* / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010793:Phthalazines / Q000009:adverse effects / Q000627:therapeutic use*; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D016016:Proportional Hazards Models; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D010793:Phthalazines; D010879:Piperazines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C531550:olaparib