title: The emerging role of soluble HLA-G in the control of chemotaxis.
abstract: HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, Via Gaslini 1, 16147 Genoa, Italy. Electronic address: fabiomorandi@ospedale-gaslini.ge.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Morandi
authors.affiliation: CEA, Institut des Maladies Emergentes et des Therapies Innovantes (iMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, Avenue Claude Vellefaux 1, 75010 Paris, France. Electronic address: Nathalie.Rouas-Freiss@cea.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rouas-Freiss
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, Via Gaslini 1, 16147 Genoa, Italy. Electronic address: vitopistoia@ospedale-gaslini.ge.it.
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation / Q000276:immunology; D002633:Chemotaxis / Q000276:immunology*; D059951:HLA-G Antigens / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D012995:Solubility; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: D059951:HLA-G Antigens
keywords: Chemokine receptors; Chemotaxis; HLA-G