title: Metabolic profiling in diabetes.
abstract: Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This review addresses issues relevant to the choice of the metabolomics platform, study design and data analysis in diabetes research, and presents recent advances using metabolomics in the identification of markers for altered metabolic pathways, biomarker discovery, challenge studies, metabolic markers of drug efficacy and off-target effects. The role of genetic variance and intermediate metabolic phenotypes and its relevance to diabetes research is also addressed.
authors.affiliation: Department of Physiology and BiophysicsQatar Foundation - Education City, Weill Cornell Medical College - Qatar, PO Box 24144, Doha, QatarInstitute of Bioinformatics and Systems BiologyHelmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyDepartment of Physiology and BiophysicsQatar Foundation - Education City, Weill Cornell Medical College - Qatar, PO Box 24144, Doha, QatarInstitute of Bioinformatics and Systems BiologyHelmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany karsten@suhre.fr.
authors.forename: Karsten
authors.initials: K
authors.lastname: Suhre
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics / Q000502:physiology*; D055442:Metabolome / Q000235:genetics / Q000502:physiology*; D055432:Metabolomics
chemical_list: D015415:Biomarkers
keywords: diabetes; glucose metabolism; insulin resistance; lipid; metabolism