title: Effect of paradoxical sleep deprivation on dna synthesis in fetal rat brain.
abstract: We have investigated the effect of PS-D induced in gestating rats by treatment with clomipramine or with the platform technique on the process of DNA synthesis taking place in fetal organs. This parameter was taken as a biochemical index of ongoing cellular proliferation. In brain and, to a minor extent, in liver and kidney the rate of fetal DNA synthesis was markedly increased in both experimental groups. The effect was more prominent in the clomipramine group. PS-D treatment of gestating rats, notably by the platform technique, left long-lasting effects in the offspring with regard to organ weight and DNA concentration as well as to learning capacity. It is concluded that the occurrence of PS in gestating rats may exert a significant influence on fetal development.
authors.affiliation: Institute of Cell Biology, Perugia Via Marconi, 10, 80125 Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Grassi-Zucconi
authors.affiliation: Institute of Cell Biology, Perugia Via Marconi, 10, 80125 Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Belia
authors.affiliation: Institute of Cell Biology, Perugia Via Marconi, 10, 80125 Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Franciolini
authors.affiliation: Institute of Cell Biology, Perugia Via Marconi, 10, 80125 Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Menichini
authors.affiliation: Institute of General Physiology and International Institute of Genetics and Biophysics, Via Marconi, 10, 80125 Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giuditta