title: Diffuse reflectance optical topography: location of inclusions in 3D and detectability limits.
abstract: In the present contribution we investigate the images of CW diffusely reflected light for a point-like source, registered by a CCD camera imaging a turbid medium containing an absorbing lesion. We show that detection of μa variations (absorption anomalies) is achieved if images are normalized to background intensity. A theoretical analysis based on the diffusion approximation is presented to investigate the sensitivity and the limitations of our proposal and a novel procedure to find the location of the inclusions in 3D is given and tested. An analysis of the noise and its influence on the detection capabilities of our proposal is provided. Experimental results on phantoms are also given, supporting the proposed approach.
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: N A
authors.initials: NA
authors.lastname: Carbone
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: G R
authors.initials: GR
authors.lastname: Baez
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: H A
authors.initials: HA
authors.lastname: García
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: M V
authors.initials: MV
authors.lastname: Waks Serra
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: H O
authors.initials: HO
authors.lastname: Di Rocco
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: D I
authors.initials: DI
authors.lastname: Iriarte
authors.affiliation: IFAS, CIFICEN (CONICET - UNCPBA) - Pinto 399- B7000GHG Tandil Argentina.
authors.forename: J A
authors.initials: JA
authors.lastname: Pomarico
authors.affiliation: PHYSIKALISCH-TECHNISCHE BUNDESANSTALT (PTB), Abbestr. 2-12, 10587 Berlin - Germany.
authors.forename: D
authors.initials: D
authors.lastname: Grosenick
authors.affiliation: PHYSIKALISCH-TECHNISCHE BUNDESANSTALT (PTB), Abbestr. 2-12, 10587 Berlin - Germany.
authors.forename: R
authors.initials: R
authors.lastname: Macdonald
keywords: (110.0113) Imaging through turbid media; (110.7050) Turbid media; (170.3880) Medical and biological imaging