title: COUP-TFs and eye development.
abstract: Recent studies reveal that COUP-TF genes are essential for neural development, cardiovascular development, energy metabolism and adipogenesis, as well as for organogenesis of multiple systems. In this review, we mainly describe the COUP-TF genes, molecular mechanisms of COUP-TF action, and their crucial functions in the morphogenesis of the murine eye. Mutations of COUP-TF genes lead to the congenital coloboma and/or optic atrophy in both mouse and human, indicating that the study on COUP-TFs and the eye will benefit our understanding of the etiology of human ocular diseases. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
authors.affiliation: Institute of Life Science, Nanchang University, Nanchang, Jiangxi 330031, China; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: ktang.sc@gmail.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Tang
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: stsai@bcm.edu.
authors.forename: Sophia Y
authors.initials: SY
authors.lastname: Tsai
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: mtsai@bcm.edu.
authors.forename: Ming-Jer
authors.initials: MJ
authors.lastname: Tsai
mesh_terms: D000818:Animals; D051836:COUP Transcription Factors / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D005123:Eye / Q000196:embryology* / Q000378:metabolism; D005128:Eye Diseases / Q000235:genetics; D006801:Humans; D051379:Mice / Q000196:embryology / Q000235:genetics; D038081:Organogenesis / Q000235:genetics*; D014981:Xenopus / Q000196:embryology / Q000235:genetics; D015027:Zebrafish / Q000196:embryology / Q000235:genetics
chemical_list: D051836:COUP Transcription Factors
keywords: COUP-TFI; COUP-TFII; Development; Eye