title: Microsatellite genome-wide association study for mandibular prognathism.
abstract: BACKGROUND
  Attempts have been made to identify susceptibility genes of mandibular prognathism by genome-wide linkage studies, but the results of susceptibility loci are inconsistent. There has been no genome-wide association study of mandibular prognathism. Our objective was to perform a genome-wide association study using 23,465 microsatellite markers to detect mandibular prognathism susceptibility regions.
  
  
  METHODS
  The study was based on the pooled DNA method, including 2 steps of screening on the whole genome and subsequent individual genotyping, with 240 experimental subjects and 360 control subjects from the Japanese population.
  
  
  RESULTS
  Two suggestive associations on chromosomes 1q32.2 (D1S1358i: P = 4.22 × 10(-4)) and 1p22.3 (D1S0411i: P = 6.66 × 10(-4)) were shown, and PLXNA2 and SSX2IP were suggested to be candidate genes; 1p22.3 flanked the region indicated by previous linkage analysis.
  
  
  CONCLUSIONS
  The results of the genome-wide association study showed that 2 loci (1q32.2 and 1p22.3) are likely to be susceptibility regions of mandibular prognathism: 1p32.2 is a novel locus, and identification of 1p22.3 supports the results of previous linkage analysis.
authors.affiliation: Postgraduate student, Division of Oral Functional Science, Department of Orthodontics, Graduate School of Dental Medicine, Hokkaido University, Hokkaido, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ikuno
authors.affiliation: Associate professor, Section of Orthodontics, Department of Oral Growth and Development, Fukuoka Dental College, Fukuoka, Japan. Electronic address: kajii@college.fdcnet.ac.jp.
authors.forename: Takashi S
authors.initials: TS
authors.lastname: Kajii
authors.affiliation: Lecturer, Institute of Medical Science, Tokai University, Kanagawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.affiliation: Professor, Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Sciences, School of Medicine, Tokai University, Kanagawa, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.affiliation: Professor, Section of Orthodontics, Department of Oral Growth and Development, Fukuoka Dental College, Fukuoka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Professor, Division of Oral Functional Science, Department of Orthodontics, Graduate School of Dental Medicine, Hokkaido University, Hokkaido, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Iida
mesh_terms: D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008313:Malocclusion, Angle Class III; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D011378:Prognathism / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C515995:PLXNA2 protein, human; D011956:Receptors, Cell Surface; D012097:Repressor Proteins; C093962:synovial sarcoma X breakpoint proteins