title: Comparison of health-related quality of life of patients with different precancer and oral cancer stages.
abstract: OBJECTIVE
  Health-related quality of life (HR-QoL) informations are becoming an important tool for the treatment concept for cancer patients. The purpose of this study was to evaluate how the quality of life depends on the disease severity of pre- and oral cancer patients and which factors influence their quality of life.
  
  
  METHODS
  During this study, 106 patients with a premalignant oral lesion, 174 patients with oral squamous cell carcinoma (OSSC) as well as 21 patients with a recurrence of OSSC were asked about their oral health-related quality of life. Additionally, the UW-QOLv4 was used to record the psychological and clinical symptoms from which the patients of the three groups are suffering.
  
  
  RESULTS
  Significant differences with respect to oral HR-QoL of life between the groups could be evaluated. Patients with a recurrence have the lowest and patients with precancer the highest HR-QoL. Within the groups, there is a difference regarding the significance of the psychological factors. The lowest values were achieved for mood within all three groups. Anxiety is of key importance for the precancer group whereas appearance and activity are of importance for the patients having a tumor. The patients of the recurrence group are heavily affected by all factors.
  
  
  CONCLUSIONS
  The quality of life differs depending on the disease. The patients of the recurrence group have the lowest oral health-related quality of life for all aspects analyzed, and they are suffering the most with respect to the psychological dimensions of the UW-QOLv4.
  
  
  CONCLUSIONS
  The present study examined the quality of life depending on the severity of the disease of pre- and oral cancer patients and which factors significantly influenced their quality of life. The evaluated findings of relevant variables may have therapeutic relevance for the multidisciplinary treatment of oral cancer patients in the future.
authors.affiliation: Department of Craniomaxillofacial Surgery, Hannover Medical School, Carl-Neuberg-Street 1, 30625, Hannover, Germany, rana.majeed@mh-hannover.de.
authors.forename: Majeed
authors.initials: M
authors.lastname: Rana
authors.forename: Nils-Claudius
authors.initials: NC
authors.lastname: Gellrich
authors.forename: Madiha
authors.initials: M
authors.lastname: Rana
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000503:physiopathology*; D011230:Precancerous Conditions / Q000473:pathology / Q000503:physiopathology*; D011788:Quality of Life