title: Efficacy of deep brain stimulation of the subthalamic nucleus on autonomic dysfunction in patients with Parkinson's disease.
abstract: Subthalamic nucleus (STN) deep brain stimulation (DBS) is well established for the treatment of the motor symptoms of Parkinson's disease (PD). However, the effect of STN DBS on autonomic symptoms has not been well studied. We examined 19 patients undergoing STN DBS for PD. The patients were administered a questionnaire to evaluate the pre-operative and post-operative autonomic function. All patients reported a significant post DBS improvement of one or more symptoms of the autonomic dysfunction (urinary and gastrointestinal function). In particular, we have shown the most significant improvement in the urinary function after STN DBS. Further larger studies are required with respect to the effect of STN DBS on the autonomic function.
authors.affiliation: Department of Neurosurgery, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pietraszko
authors.affiliation: Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Furgala
authors.affiliation: Department of Neurosurgery, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gorecka-Mazur
authors.affiliation: Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Thor
authors.affiliation: Department of Neurosurgery, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Moskala
authors.affiliation: Department of Neurosurgery, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polak
authors.affiliation: AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Krakow, Poland.
authors.forename: Artur D
authors.initials: AD
authors.lastname: Surowka
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, Krakow, Poland. krygowska@neuro.cm-uj.krakow.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Krygowska-Wajs
mesh_terms: D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D011184:Postoperative Period; D057234:Preoperative Period; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology / Q000628:therapy*