title: Successful bortezomib/dexamethasone induction therapy with lenalidomide in an elderly patient with primary plasma cell leukemia complicated by renal failure and pulmonary hypertension.
abstract: Primary plasma cell leukemia (PPCL) is a rare disease that progresses rapidly. In such cases, it is difficult to achieve remission, and early intensive chemotherapy is recommended. We herein describe the case of a 76-year-old man with PPCL complicated by renal failure and pulmonary hypertension. Bortezomib/dexamethasone induction therapy with lenalidomide was administered in association with continuous hemodiafiltration (CHDF). Complete remission was achieved after a single course of treatment, resulting in the cessation of CHDF. With the patient in remission, the administration of beraprost and bosentan resulted in improvements in the pulmonary hypertension. The results of this case report support the use of bortezomib/lenalidomide/dexamethasone combination therapy as an effective treatment for elderly PPCL patients with various complications.
authors.affiliation: Department of Hematology/Oncology, Kinan Hospital, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tamura
authors.forename: Asumi
authors.initials: A
authors.lastname: Koyama
authors.forename: Chieko
authors.initials: C
authors.lastname: Shiotani
authors.forename: Toshio
authors.initials: T
authors.lastname: Kurihara
authors.forename: Akinori
authors.initials: A
authors.lastname: Nishikawa
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Tokuzo
authors.initials: T
authors.lastname: Fujimoto
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D060828:Induction Chemotherapy; D000077269:Lenalidomide; D007952:Leukemia, Plasma Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011719:Pyrazines / Q000008:administration & dosage; D012074:Remission Induction; D051437:Renal Insufficiency / Q000209:etiology; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D003907:Dexamethasone; D000077269:Lenalidomide