title: Comparative study of 17 β-estradiol on endocrine disruption and biotransformation in fingerlings and juveniles of Japanese sea bass Lateolabrax japonicus.
abstract: Estrogenic contaminants in the aquatic environment are associated with endocrine disruption and feminization in fish. The effects of endocrine disrupting chemicals (EDCs) on fish have been well documented. However, very few studies have focused on 17 β-estradiol (E2) and its effects on endocrine system and biotransformation in a single prolonged exposure. This study investigated changes in the levels of serotonin (5-hydroxytryptamine) and acetyl choline esterase (AchE) in brain, cortisol in plasma and Ethoxyresorufin-O-deethylase (EROD) activity in gill of two different size groups (fingerlings and juveniles) of Japanese sea bass (Lateolabrax japonicus) upon exposure to two sub-lethal concentrations (200 and 2000 ng L(-1)) of E2 for 30 d. The results indicate that cortisol level and EROD activity significantly increased in both groups, whereas serotonin level increased in juveniles and decreased in fingerlings due to E2 exposure. The correlation analysis revealed that E2 significantly affected the endocrine and biotransformation systems in both age groups.
authors.affiliation: State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Harikrishnan
authors.initials: H
authors.lastname: Thilagam
authors.affiliation: State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361005, China. Electronic address: sing_gopal@yahoo.com.
authors.forename: Singaram
authors.initials: S
authors.lastname: Gopalakrishnan
authors.affiliation: State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Bo
authors.affiliation: State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361005, China. Electronic address: wkjian@xmu.edu.cn.
authors.forename: Ke-Jian
authors.initials: KJ
authors.lastname: Wang
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001492:Bass / Q000254:growth & development* / Q000378:metabolism; D001711:Biotransformation; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity*; D004703:Endocrine System / Q000187:drug effects; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D005880:Gills / Q000187:drug effects / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D012701:Serotonin / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical; D012701:Serotonin; D004958:Estradiol; D019363:Cytochrome P-450 CYP1A1; D000110:Acetylcholinesterase; D006854:Hydrocortisone
keywords: Cortisol; EROD; Estradiol; Lateolabrax japonicus; Serotonin