title: Liquid human milk fortifier significantly improves docosahexaenoic and arachidonic acid status in preterm infants.
abstract: We report the fatty acid composition of mother׳s own human milk from one of the largest US cohorts of lactating mothers of preterm infants. Milk fatty acid data were used as a proxy for intake at enrollment in infants (n=150) who received human milk with a powder human milk fortifier (HMF; Control) or liquid HMF [LHMF; provided additional 12mg docosahexaenoic acid (DHA), 20mg arachidonic acid (ARA)/100mL human milk]. Mothers provided milk samples (n=129) and reported maternal DHA consumption (n=128). Infant blood samples were drawn at study completion (Study Day 28). Human milk and infant PPL fatty acids were analyzed using capillary column gas chromatography. DHA and ARA were within ranges previously published for US term and preterm human milk. Compared to Control HMF (providing no DHA or ARA), human milk fortified with LHMF significantly increased infant PPL DHA and ARA and improved preterm infant DHA and ARA status.
authors.affiliation: Department of Medical Affairs, Clinical Research, Mead Johnson Nutrition, 2400 West Lloyd Expy, Evansville, IN 47721, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Berseth
authors.affiliation: Department of Medical Affairs, Clinical Research, Mead Johnson Nutrition, 2400 West Lloyd Expy, Evansville, IN 47721, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Harris
authors.affiliation: Department of Medical Affairs, Clinical Research, Mead Johnson Nutrition, 2400 West Lloyd Expy, Evansville, IN 47721, USA. Electronic address: jennifer.wampler@mjn.com.
authors.forename: J L
authors.initials: JL
authors.lastname: Wampler
authors.affiliation: Retina Foundation of the Southwest, 9900 North Central Expressway, Dallas, TX 75231, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Hoffman
authors.affiliation: College of Human Ecology, Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, NY 14853, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Diersen-Schade
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000097:blood; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005527:Food, Fortified; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008895:Milk, Human
chemical_list: D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid
keywords: Breast feeding; Human milk fortifier; Preterm infants