title: Direct asymmetric dearomatization of pyridines and pyrazines by iridium-catalyzed allylic amination reactions.
abstract: The first iridium-catalyzed intramolecular asymmetric allylic dearomatization reaction of pyridines and pyrazines has been realized. 2,3-Dihydroindolizine and 6,7-dihydropyrrolo[1,2-a]pyrazine derivatives were obtained with excellent yields and enantioselectivity. This methodology features dearomatization by direct N-allylic alkylation of pyridines or pyrazines under mild reaction conditions.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/
authors.forename: Ze-Peng
authors.initials: ZP
authors.lastname: Yang
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Wu
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
keywords: allylic compounds; asymmetric catalysis; cyclization; heterocycles; iridium