title: [Poststroke cognitive, emotional impairment and sleep quality: efficience of treatment with melaxen].
abstract: OBJECTIVE
  To study melatonin secretion and its correlations with poststroke cognitive, emotional impairment and sleep quality in the acute period of stroke and to assess treatment efficacy of melaxen.
  
  
  METHODS
  We studied 96 patients with acute stroke. A battery of tests and scales for assessment of neurological deficit, neuropsychological status and emotional impairment was used. The night urinary level of 6-sulfatoxymelatonin was assessed. The relationship between 6-sulfatoxymelatonin and cognitive, emotional status and sleep parameters was analyzed.
  
  
  RESULTS
  The level of 6-sulfatoxymelatonin was decreased in the night urine. Patients with dysexecutive poststroke cognitive impairment had higher level of 6-sulfatoxymelatonin and patients with dysmnestic and mixed cognitive impairment had lower level of 6-sulfatoxymelatonin in comparison with patients with normal cognitive functions. Melaxen improved cognitive function and sleep parameters, reduced the level of anxiety in the early recovery period of stroke.
  
  
  CONCLUSIONS
  A role of chronobiological processes in the development of clinical signs of stroke in the aspect of cognitive impairment is discussed.
authors.forename: A A
authors.initials: AA
authors.lastname: Kulesh
authors.forename: V V
authors.initials: VV
authors.lastname: Shestakov
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology*; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000209:etiology*; D009483:Neuropsychological Tests; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D020521:Stroke / Q000150:complications* / Q000378:metabolism / Q000523:psychology; D016896:Treatment Outcome
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin