title: Interleukin-1β level in peri-implant crevicular fluid and its correlation with the clinical and radiographic parameters.
abstract: OBJECTIVE
  Assessing only the clinical and radiographic parameters for evaluation of dental implants may not be enough as they often reflect extensive inflammatory changes in the periodontal tissues. As peri-implant crevicular fluid (PICF) can give us a more prompt and objective measure of the disease activity, the purpose of this case series is to assess the peri-implant health status of single tooth dental implants not only clinically and radiographically but also biochemically.
  
  
  METHODS
  Thirteen patients were subjected to dental implants at single edentulous sites using a conventional surgical approach. At baseline, 6 months, and 12 months after implant placement, the clinical and radiographic parameters were recorded. Additionally, IL-1β in PICF was estimated using the ELISA kit at 6(th) and 12(th) month.
  
  
  RESULTS
  The clinical and radiographic parameters differed significantly around the implants at different time intervals with IL-1β levels showing highly significant differences between 6 months (31.79 ± 12.26 pg/μl) and 12 months (113.09 ± 51.11 pg/μl). However, Spearman's correlation coefficient showed no correlation with the clinical and radiographic parameters.
  
  
  CONCLUSIONS
  Assessment of the various parameters confirmed that all the implants had a healthy peri-implant status. Although the levels of IL-1β in PICF were elevated at the 12(th) month, they were well within the healthy range as observed by previous studies. This indicates that IL-1β, a biochemical marker, can be used as an adjunct to clinical and radiographic parameters in the assessment of EARLY inflammatory changes around implants.
authors.affiliation: Department of Periodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
authors.forename: Aniruddha M
authors.initials: AM
authors.lastname: Kajale
authors.affiliation: Department of Periodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
authors.forename: Dhoom S
authors.initials: DS
authors.lastname: Mehta
keywords: Dental implant; interleukin-1β; peri-implant crevicular fluid