title: Antibiotic resistance in nosocomial respiratory infections.
abstract: Nosocomial respiratory infections are the most common acquired infections in patients with severe underlying conditions and are responsible for high morbidity and mortality in this patient population. Multidrug-resistant (MDR) pathogens are associated with hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). This article describes the etiology, epidemiology, pathogenesis, diagnosis, and treatment of HAP and VAP associated with antibiotic-resistant bacterial pathogens.
authors.affiliation: Division of Clinical Microbiology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Room 6027B, Indianapolis, IN 46202, USA. Electronic address: gdenys@iupui.edu.
authors.forename: Gerald A
authors.initials: GA
authors.lastname: Denys
authors.affiliation: Division of Clinical Microbiology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Room 6027B, Indianapolis, IN 46202, USA.
authors.forename: Ryan F
authors.initials: RF
authors.lastname: Relich
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D003428:Cross Infection / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D053717:Pneumonia, Ventilator-Associated / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Health care–associated infections; Hospital-acquired pneumonia; Multidrug resistant pathogens; Nosocomial; Ventilator-associated pneumonia