title: Markers of platelet activation are increased in adolescents with type 2 diabetes.
abstract: OBJECTIVE
  In adults with diabetes, in vivo platelet activation is a marker for atherosclerosis and cardiovascular disease (CVD). This pilot study investigated whether adolescents with diabetes had evidence of increased in vivo platelet activation.
  
  
  METHODS
  In vivo platelet activation was compared in four groups of age-matched adolescents: type 1 diabetes (T1D, n = 15), type 2 diabetes (T2D; n = 15), control subjects with normal BMI (n = 14), and overweight/obese control subjects (n = 13). Platelet surface activation markers and plasma levels of soluble activation markers were measured and compared among groups.
  
  
  RESULTS
  Increased expression of all activation markers was observed in T2D compared with either control group (P < 0.05); levels of soluble markers were also higher in T2D than in T1D (P < 0.05). There were no differences in marker expression between the nondiabetic control groups.
  
  
  CONCLUSIONS
  Platelet activation in adolescents with T2D may be a marker for the risk of CVD development in early adulthood.
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada israels@cc.umanitoba.ca.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Israels
authors.affiliation: Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Archibald
authors.initials: A
authors.lastname: McNicol
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Dean
authors.affiliation: Groupe Immunité des Muqueuses et Agents Pathogènes-EA 3064, Faculty of Medicine, University of Lyon/Saint-Etienne, Saint-Etienne, FranceEtablissement Français du Sang Auvergne-Loire, Saint-Etienne, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Cognasse
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Elizabeth A C
authors.initials: EA
authors.lastname: Sellers
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood; D050177:Overweight / Q000097:blood; D010865:Pilot Projects; D015539:Platelet Activation
chemical_list: D015415:Biomarkers