title: Carcinosarcoma of the corpus uteri (Malignant Müllerian Mixed Tumor): a case report in Yaoundé (Cameroon).
abstract: Carcinosarcoma of the uterus is a rare tumor representing 2-4% of uterine malignancies. Its prognosis is poor with a 5 years survival rate of 10-30%. We report a first documented case of carcinosarcoma occurring in a 62 years old woman who presented with postmenopausal vaginal bleeding for one year. The preoperative biopsy of endometrium revealed a leiomyosarcoma. Total body Computerized Tomography (CT) Scan revealed a mass limited to the uterus without other abnormalities. We carried out a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Post operative histology of the specimen found a carcinosarcoma. The patient underwent a course of radiotherapy and a total body CT Scan done eight months later revealed no signs of recurrence or metastasis. Clinicopathological aspects, treatment options and prognosis of this aggressive neoplasm are reviewed. We recommend practitioners to be aware of this lesion for an early diagnosis and appropriate treatment.
authors.affiliation: Yaounde Gyneco-Obstetric and Pediatric Hospital, Cameroon ; Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1, Cameroon.
authors.forename: Zacharie
authors.initials: Z
authors.lastname: Sando
authors.affiliation: Yaoundé Central Hospital, Cameroon.
authors.forename: Florent Ymele
authors.initials: FY
authors.lastname: Fouelifack
authors.affiliation: Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1, Cameroon.
authors.forename: Jovanny Tsuala
authors.initials: JT
authors.lastname: Fouogue
authors.affiliation: Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1, Cameroon.
authors.forename: Jeanne Hortence
authors.initials: JH
authors.lastname: Fouedjio
authors.affiliation: Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1, Cameroon.
authors.forename: Chimene Etonga
authors.initials: CE
authors.lastname: Anoudem
authors.affiliation: Yaoundé Central Hospital, Cameroon.
authors.forename: Charlette
authors.initials: C
authors.lastname: Nangue
mesh_terms: D002163:Cameroon; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis* / Q000601:surgery; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000601:surgery
keywords: Cameroon; Cancer; Carcinosarcoma; endometrium; uterus