title: Acquired idiopathic anhidrosis: a diagnosis often missed.
abstract: BACKGROUND
  Acquired idiopathic anhidrosis (AIA) is an uncommon entity characterized by anhidrosis in the absence of any neurologic or sweat gland abnormalities.
  
  
  OBJECTIVE
  The aim of this study was to characterize the clinical profile in a cohort of patients diagnosed with AIA at a tertiary dermatologic center.
  
  
  METHODS
  We retrospectively evaluated cases seen during a 10-year period. Inclusion criteria included all cases of generalized or partial anhidrosis with no obvious causes, confirmed by provocative starch-iodine sweat test. Ectodermal dysplasias, poral dysfunction from chronic dermatoses, autonomic dysfunction, and drug-induced causes were excluded.
  
  
  RESULTS
  Fifteen Chinese patients were diagnosed with AIA, mostly healthy young men with no significant medical or drug history, with variable extent of body surface area involvement. Serum immunoglobulin E, a complete blood cell count, thyroid function test, and antinuclear antibody levels were unremarkable. Anhidrotic areas revealed normal eccrine appendages with mild perivascular and perieccrine lymphocytic infiltrate. There were no neurologic abnormalities.
  
  
  CONCLUSIONS
  This was a retrospective study.
  
  
  CONCLUSIONS
  Our study shows that AIA seems to be a heterogeneous group with no major dysfunction other than anhidrosis. Proper recognition and evaluation is paramount, especially for at-risk populations, so that appropriate measures on the prevention of heat injuries can be instituted.
authors.affiliation: Department of Dermatology, Changi General Hospital, Simei, Singapore. Electronic address: drtaylk@yahoo.com.sg.
authors.forename: Liang Kiat
authors.initials: LK
authors.lastname: Tay
authors.affiliation: National Skin Centre, Simei, Singapore.
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Chong
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D007007:Hypohidrosis / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: acquired idiopathic generalized anhidrosis; anhidrosis; hypohidrosis; sweat gland dysfunction