title: Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?
abstract: In a growing outpatient surgical population, postdischarge nausea and vomiting (PDNV) is unfortunately a common and costly anesthetic complication. Identification of risk factors for both postoperative nausea and vomiting and PDNV is the hallmark of prevention and management. New pharmacologic interventions with extended duration of action, including palonosetron and aprepritant, may prove to be more efficacious.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: M Stephen
authors.initials: MS
authors.lastname: Melton
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Karen C
authors.initials: KC
authors.lastname: Nielsen
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Marcy
authors.initials: M
authors.lastname: Tucker
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Klein
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: tjgan@duke.edu.
authors.forename: Tong J
authors.initials: TJ
authors.lastname: Gan
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D064729:Neurokinin-1 Receptor Antagonists / Q000627:therapeutic use*; D000077924:Palonosetron; D010351:Patient Discharge; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*; D011812:Quinuclidines / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000932:Antiemetics; D007546:Isoquinolines; D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D012702:Serotonin Antagonists; D000077924:Palonosetron
keywords: Aprepitant; Casopitant; Nausea; Palonosetron; Postdischarge; Postoperative; Rolapitant; Vomiting