title: Manipulating the epigenome in germinal center lymphomas: is it getting easier and ezier?
abstract: Mutations affecting key epigenetic modifiers tend to cluster in malignancies in which cells of origin lie in the germinal center (GC). EZH2, as transcriptional repressor, is mutated in high frequency in Chinese and Western patients with follicular lymphoma and may represent a rational target for GC-derived lymphomas. .
authors.affiliation: Authors' Affiliation: Center for Lymphoid Malignancies, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Amengual
authors.affiliation: Authors' Affiliation: Center for Lymphoid Malignancies, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York oo2130@cumc.columbia.edu.
authors.forename: Owen A
authors.initials: OA
authors.lastname: O'Connor
mesh_terms: D000071221:Enhancer of Zeste Homolog 2 Protein; D057890:Epigenomics; D018858:Germinal Center / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D063151:Polycomb Repressive Complex 2 / Q000235:genetics*
chemical_list: C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2