title: [Efficiency and safety of allapinin in short- and long-term treatment of patients with normal heart and ventricular premature beats].
abstract: Allapinin, class 1C antiarrhythmic drug, is highly effective in treatment of patients with ventricular premature beats (VPB). The purpose of work was retrospective assessment of efficacy and safety of allapinin in patients with benign ventricular arrhythmias. 73 patients with VPB and no structural heart disease were selected from a database. In short course allapininin in dose of 75-150 mg per os daily decreased the number of VPB for more than 90% in 46,6% of patients. In 34,4% cases tolerable drug side effects were observed. Among patients with VPB burden of 10% and higher allapinin reduced this quantity below the indicated value in 76% of cases with tolerable drug side effects in 38,6% of cases. In long treatment study antiarrhythmic effect of allapinin persisted and no other side effects of the drug were documented.
  
  
  CONCLUSIONS
  Allapinin is highly effective in treatment of patients with VPB without structural heart disease.
authors.forename: S F
authors.initials: SF
authors.lastname: Sokolov
authors.forename: S A
authors.initials: SA
authors.lastname: Bakalov
authors.forename: N A
authors.initials: NA
authors.lastname: Mironova
authors.forename: M M
authors.initials: MM
authors.lastname: Rogova
authors.forename: T A
authors.initials: TA
authors.lastname: Malkina
authors.forename: S P
authors.initials: SP
authors.lastname: Golitsyn
mesh_terms: D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018879:Ventricular Premature Complexes / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000889:Anti-Arrhythmia Agents; C051402:allapinin; D000157:Aconitine