title: [Radiobiology of ablative dose in stereotactic irradiation: data update].
abstract: Stereotactic radiotherapy is a radiation technique, which is becoming more and more available and applicable for physicians. A good efficacy and safety are observed in clinical practice. However, the radiobiology of ablative radiation is still under question. The radiobiological principles of the 5R have to be discussed. The roles of hypoxia and vascularization, more specifically, angiogenesis and vasculogenesis seem to be dominating.
authors.affiliation: Département universitaire de radiothérapie, centre de lutte contre le cancer Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France.
authors.forename: D N
authors.initials: DN
authors.lastname: Antoni
authors.affiliation: EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France.
authors.forename: H
authors.initials: H
authors.lastname: Burckel
authors.affiliation: EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France.
authors.forename: É
authors.initials: É
authors.lastname: Josset
authors.affiliation: Département universitaire de radiothérapie, centre de lutte contre le cancer Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; EA 3430, laboratoire de radiobiologie, centre Paul-Strauss, université de Strasbourg, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg, France. Electronic address: gnoel@strasbourg.unicancer.fr.
authors.forename: G
authors.initials: G
authors.lastname: Noël
authors.affiliation: Département de radiothérapie oncologique, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite-Lyon, France; EA 3738, université Claude-Bernard - Lyon-1, domaine Rockefeller, 8, avenue Rockefeller, 69373 Lyon cedex 08, France.
authors.forename: F
authors.initials: F
authors.lastname: Mornex
mesh_terms: D017209:Apoptosis; D002453:Cell Cycle / Q000528:radiation effects; D015687:Cell Hypoxia / Q000528:radiation effects; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D016014:Linear Models; D008566:Membranes / Q000528:radiation effects; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D009389:Neovascularization, Pathologic / Q000628:therapy; D010100:Oxygen / Q000378:metabolism; D016634:Radiosurgery; D011879:Radiotherapy Dosage
chemical_list: D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen
keywords: Ablative dose; Angiogenesis; Angiogenèse; Dose ablative; Hypoxia; Hypoxie; Radiobiologie; Radiobiology; Stereotactic; Stéréotaxie; Vasculogenesis; Vasculogenèse