title: Osseointegration of polyethylene implants coated with titanium and biomimetically or electrochemically deposited hydroxyapatite in a rabbit model.
abstract: OBJECTIVE
  The aim of this study was to evaluate the osseointegration of a new coating directly deposited on PE at room temperature.
  
  
  METHODS
  Thirty-six (36) male New Zealand rabbits were randomly assigned to receive one out of three types of implants: two tested implants, i.e. PE implant coated with TiPVD and biomimetic HA (biomimetic), PE implant coated with TiPVD and electrolytic HA (electrolytic), and positive control made of massive microrough titanium coated with plasma sprayed HA (TiHAPS). Osseointegration was evaluated by histomorphometry (bone tissue in contact [BIC]), mineralized bone area [MBA]) and mechanical testing (push-out test, interfacial shear strength [ISS]) at six and 12 weeks in the distal femurs.
  
  
  RESULTS
  For BIC there were no differences between the groups at six (p = 0.98) and 12 weeks (p = 0.13). For MBA, no statistically significant difference was measured between groups at six (p = 0.52) and 12 weeks (p = 0.57). At six weeks, interfacial shear strength (ISS) was significantly higher (p = 0.01) for TiHAPs implants compared to biomimetic and electrolytic implants. This difference was not significant at 12 weeks (p = 0.92).
  
  
  CONCLUSIONS
  The osseointegration of biomimetic and electrolytic implants was equivalent to a positive control at 12 weeks.
authors.affiliation: Cochin Hospital, Paris, France, scemamacaroline@gmail.com.
authors.forename: Caroline
authors.initials: C
authors.lastname: Scemama
authors.forename: Bertrand
authors.initials: B
authors.lastname: David
authors.forename: Morad
authors.initials: M
authors.lastname: Bensidhoum
authors.forename: Moussa
authors.initials: M
authors.lastname: Hamadouche
mesh_terms: D000077:Acetabulum / Q000502:physiology / Q000601:surgery; D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation; D032701:Biomimetics / Q000379:methods*; D017886:Durapatite; D004563:Electrochemistry; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D016348:Osseointegration / Q000502:physiology*; D020959:Polyethylene; D019736:Prostheses and Implants; D011817:Rabbits; D033081:Shear Strength; D013314:Stress, Mechanical; D013997:Time Factors; D014025:Titanium
chemical_list: D020959:Polyethylene; D017886:Durapatite; D014025:Titanium