title: [Association of microRNA-related genes (DROSHA, DICER1 and GEMIN4) polymorphisms with T-cell lymphoma prognosis].
abstract: OBJECTIVE
  To analyze the association of micoRNA-related genes DROSHA single nucleotide polymorphisms (SNP) rs10719 and rs6877842, DICER1 rs3742330and GEMIN4 rs3744741 with prognosis of T-cell lymphoma.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determine the genotypes of the above 4SNPs and their associations with complete remission (CR) rate and overall survival (OS) in 163 patients with TCL.
  
  
  RESULTS
  Patients carrying the rs6877842 CG genotype had a significantly higher CR rate compared with those carrying the CC genotype (OR=0.07, 95% CI 0.01-0.72, P=0.026); the same for patients carrying the DICER1 rs3742330 GG genotype compared with those carrying the GA genotype (OR=0.15, 95% CI 0.02-0.97, P=0.047) or the AA genotype (OR=0.11, 95% CI 0.02-0.71, P=0.020). In addition, patients with the DICER1 rs3742330 GG genotype had a significantly improved OS compared with those carrying the GA (HR=9.02, 95% CI 1.22-66.92, P=0.031) or AA genotype (HR=8.77, 95% CI 1.19-64.67, P=0.033). The other two SNPs of rs10719 and rs3744741 had no significant association with CR or OS.
  
  
  CONCLUSIONS
  DROSHA rs6877842 and DICER1 rs3742330 were independent factors for TCL CR, and DICER1 rs3742330 was also an independent prognostic factor for TCL OS.
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Zhai
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jieping
authors.initials: J
authors.lastname: Chen
mesh_terms: D053487:DEAD-box RNA Helicases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D015778:Minor Histocompatibility Antigens; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D043244:Ribonuclease III / Q000235:genetics*; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics*
chemical_list: C406815:GEMIN4 protein, human; D035683:MicroRNAs; D015778:Minor Histocompatibility Antigens; D017411:Ribonucleoproteins, Small Nuclear; C408087:DICER1 protein, human; C517918:DROSHA protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases