title: Spectrum of neurodevelopmental disabilities: a cohort study in hungary.
abstract: The spectrum of neurodevelopmental disabilities was studied in a cohort of patients in Hungary. A search for etiologies and assessment of the degree of intellectual disability were carried out. The study included 241 (131 boys) patients. Disability occurred without any prenatal, perinatal, and/or neonatal adverse events in 167 patients. They were classified into the following subgroups: genetic syndromes with recognized etiology, global developmental delay/intellectual disability in association with dysmorphic features but unknown etiology, global developmental delay/intellectual disability without dysmorphic features and recognized etiology, brain malformations, inborn errors of metabolism, leukoencephalopathies, epileptic syndromes, developmental language impairment, and neuromuscular disorders. Adverse events occurred in 74 children classified into subgroups such as cerebral palsy after delivery preterm or at term, and disabilities without cerebral palsy. The etiology was identified in 66.4%, and genetic diagnosis was found in 19.5%. Classification of neurodevelopmental disorders contribute to etiological diagnosis, proper rehabilitation, and genetic counseling.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Szeged, Szeged, Hungary 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: Gyurgyinka
authors.initials: G
authors.lastname: Gergev
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Adrienn
authors.initials: A
authors.lastname: Máté
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Alíz
authors.initials: A
authors.lastname: Zimmermann
authors.affiliation: Department of Medical Physics and Informatics, Faculty of Medicine, University of Szeged, Szeged, Hungary Bolyai Institute, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rárosi
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Szeged, Szeged, Hungary sztriha.laszlo@med.u-szeged.hu.
authors.forename: László
authors.initials: L
authors.lastname: Sztriha
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007223:Infant; D008607:Intellectual Disability / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult
keywords: genetic syndromes; global developmental delay; intellectual disability; single domain developmental delay