title: Efficacy of vaccination on Staphylococcus aureus and coagulase-negative staphylococci intramammary infection dynamics in 2 dairy herds.
abstract: The aim of this study was to evaluate vaccine efficacy of a commercial vaccine (Startvac, Hipra Spain) aimed at reducing intramammary infections (IMI) with Staphylococcus aureus and coagulase-negative staphylococci under field conditions. During the 21-mo duration of the study, 1,156 lactations from 809 cows were enrolled in 2 herds. During the first phase of the trial, all cows that were due to calve were vaccinated until approximately 50% of cows in the milking herd were vaccinated (at ~6mo). At that point, when 50% vaccination coverage was reached, cows that were due to calve were randomly assigned to be vaccinated or left as negative controls. Cure rate, rate of new infection, prevalence, and duration of infections were analyzed. Vaccination resulted in a moderate reduction in incidence of new staphylococcal IMI and a more pronounced reduction in duration of IMI associated with reduction of the basic reproduction ratio of Staph. aureus by approximately 45% and of coagulase-negative staphylococci by approximately 35%. The utilization of vaccine in combination with other infection-control procedures, such as excellent milking procedures, treatment, segregation, and culling of known infected cattle, will result in an important reduction in incidence and duration of intramammary staphylococcal infections.
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; GD Animal Health, Arnsbergstraat 7, 7418 EZ Deventer, the Netherlands. Electronic address: y.schukken@gddeventer.com.
authors.forename: Y H
authors.initials: YH
authors.lastname: Schukken
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Bronzo
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Locatelli
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie e Sanità Pubblica, via Celoria 10, 20133 Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pollera
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Rota
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Casula
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Testa
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Scaccabarozzi
authors.affiliation: Hipra S. A. Laboratorios, Avenida La Selva 135, Amer (Girona), Spain.
authors.forename: R
authors.initials: R
authors.lastname: March
authors.affiliation: Hipra S. A. Laboratorios, Avenida La Selva 135, Amer (Girona), Spain.
authors.forename: D
authors.initials: D
authors.lastname: Zalduendo
authors.affiliation: Hipra S. A. Laboratorios, Avenida La Selva 135, Amer (Girona), Spain.
authors.forename: R
authors.initials: R
authors.lastname: Guix
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; Università degli Studi di Milano, Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, via Celoria 10, 20133 Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Moroni
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002417:Cattle; D003030:Coagulase / Q000378:metabolism; D005260:Female; D015994:Incidence; D008414:Mastitis, Bovine / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D013211:Staphylococcus aureus / Q000276:immunology*; D014611:Vaccination / Q000592:standards / Q000662:veterinary*
chemical_list: D001428:Bacterial Vaccines; D003030:Coagulase
keywords: Staphylococcus aureus; coagulase-negative staphylococci; intramammary infection; vaccine