title: Could baseline health-related quality of life (QoL) predict overall survival in metastatic colorectal cancer? The results of the GERCOR OPTIMOX 1 study.
abstract: BACKGROUND
  Health-related quality of life (QoL) has prognostic value in many cancers. A recent study found that the performance of prognostic systems for metastatic colorectal cancer (mCRC) were improvable. We evaluated the independent prognostic value of QoL for overall survival (OS) and its ability to improve two prognostic systems'performance (Köhne and GERCOR models) for patients with mCRC.
  
  
  METHODS
  The EQ-5D questionnaire was self-completed before randomization in the OPTIMOX1, a phase III trial comparing two strategies of FOLFOX chemotherapy which included 620 previously untreated mCRC patients recruited from January 2000 to June 2002 from 56 institutions in five countries. The improvement in models' performance (after addition of QoL) was studied with Harrell's C-index and the net reclassification improvement.
  
  
  RESULTS
  Of the 620 patients, 249 (40%) completed QoL datasets. The Köhne model could be improved by LDH, mobility and pain/discomfort; the C-index rose from 0.54 to 0.67. The associated NRI for 12-month death was 0.23 [0.05; 0.46]. Mobility and pain/discomfort could be added to the GERCOR model: the C-index varied from 0.63 to 0.68. The NRI for 12 months death was 0.35 [0.12; 0.44].
  
  
  CONCLUSIONS
  Mobility and pain dimensions of EQ5D are independent prognostic factors and could be useful for staging and treatment assignment of mCRC patients. Presented at the 2011 ASCO Annual Meeting (#3632).
authors.affiliation: Direction de la Recherche Clinique et de l'Innovation, Centre Hospitalier Universitaire Amiens, Nord, 1, Place Victor Pauchet, F-80054, Amiens, Cedex, France. diouf.momar@chu-amiens.fr.
authors.forename: Momar
authors.initials: M
authors.lastname: Diouf
authors.forename: Benoist
authors.initials: B
authors.lastname: Chibaudel
authors.forename: Thomas
authors.initials: T
authors.lastname: Filleron
authors.forename: Christophe
authors.initials: C
authors.lastname: Tournigand
authors.forename: Marine
authors.initials: M
authors.lastname: Hug de Larauze
authors.forename: Marie-Line
authors.initials: ML
authors.lastname: Garcia-Larnicol
authors.forename: Sarah
authors.initials: S
authors.lastname: Dumont
authors.forename: Christophe
authors.initials: C
authors.lastname: Louvet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Perez-Staub
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hadengue
authors.forename: Aimery
authors.initials: A
authors.lastname: de Gramont
authors.forename: Franck
authors.initials: F
authors.lastname: Bonnetain
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010146:Pain / Q000175:diagnosis / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016019:Survival Analysis