title: [Tooth eruption disturbances and syndromes].
abstract: In the tooth eruption mechanism, various disturbances can appear as a result of gene mutations, a consequence of which can be that tooth eruption does not occur. There are 5 syndromes which involve the complete failure of several or even all teeth to erupt, specifically: cleidocranial dysplasia, Gardner's syndrome, osteopetrosis, mucopolysaccharidosis and GAPO syndrome. Some are very rare and will seldom be encountered in a dental practice, but they show how vulnerable the tooth eruption mechanism is. Dentists are generally the ones who identify a tooth eruption problem in a patient. Since syndromes can be associated with other disorders, additional investigation by a clinical geneticist is always important when a syndrome is suspected.
authors.forename: B C M
authors.initials: BC
authors.lastname: Oosterkamp
authors.forename: C W
authors.initials: CW
authors.lastname: Ockeloen
authors.forename: C E L
authors.initials: CE
authors.lastname: Carels
authors.forename: A M
authors.initials: AM
authors.lastname: Kuijpers-Jagtman
mesh_terms: D000505:Alopecia / Q000235:genetics / Q000503:physiopathology; D000848:Anodontia / Q000235:genetics / Q000503:physiopathology; D002973:Cleidocranial Dysplasia / Q000235:genetics / Q000503:physiopathology; D005736:Gardner Syndrome / Q000235:genetics / Q000503:physiopathology; D006130:Growth Disorders / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D009083:Mucopolysaccharidoses / Q000235:genetics / Q000503:physiopathology; D015418:Optic Atrophies, Hereditary / Q000235:genetics / Q000503:physiopathology; D010022:Osteopetrosis / Q000235:genetics / Q000503:physiopathology; D014078:Tooth Eruption / Q000235:genetics* / Q000502:physiology*; D014097:Tooth, Unerupted / Q000235:genetics*