title: Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells.
abstract: Several studies have demonstrated the important role of non-coding RNAs as regulators of posttranscriptional processes, including stem cells self-renewal and neural differentiation. Human embryonic stem cells (hESCs) and induced pluripotent stem cells (ihPSCs) show enormous potential in regenerative medicine due to their capacity to differentiate to virtually any type of cells of human body. Deciphering the role of non-coding RNAs in pluripotency, self-renewal and neural differentiation will reveal new molecular mechanisms involved in induction and maintenances of pluripotent state as well as triggering these cells toward clinically relevant cells for transplantation. In this brief review we will summarize recently published studies which reveal the role of non-coding RNAs in pluripotency and neural differentiation of hESCs and ihPSC.
authors.affiliation: Retina Group, Cell therapy and Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina Regenerativa Sevilla, Spain.
authors.forename: Dunja
authors.initials: D
authors.lastname: Lukovic
authors.affiliation: Neuronal and Tissue Regeneration Lab, Centro de Investigación Príncipe Felipe Valencia, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Moreno-Manzano
authors.affiliation: Integrated Center of Cellular Therapy and Regenerative Medicine - International Clinical Research Center, St. Anne's University Hospital Brno Brno, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Klabusay
authors.affiliation: Spebo Medical Leskovac, Serbia ; Human Genetics Department, Faculty of Medical Sciences, University of Kragujevac Kragujevac, Serbia.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Stojkovic
authors.affiliation: Retina Group, Cell therapy and Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina Regenerativa Sevilla, Spain.
authors.forename: Shomi S
authors.initials: SS
authors.lastname: Bhattacharya
authors.affiliation: Retina Group, Cell therapy and Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina Regenerativa Sevilla, Spain.
authors.forename: Slaven
authors.initials: S
authors.lastname: Erceg
keywords: differentiation; human embryonic stem cells; non-coding RNA; pluripotency; pluripotent stem cells