title: Oral metastasis of metaplastic breast carcinoma in a patient with neurofibromatosis 1.
abstract: Neurofibromatosis type 1 (NF1) has been associated with an increased risk for development of malignancy, especially malignant peripheral nerve sheath tumors. In addition, recently, literature has demonstrated an increased risk of breast cancer in women with NF1. The present paper shows a 53-year-old woman with NF1 who presented with metaplastic breast carcinoma and developed multiple metastases, including mandible. Furthermore, we reviewed the English literature, found 63 cases showing the association between NF1 and breast cancer, and added one more case. The present study demonstrated an important association between NF1 and breast cancer. Until the present time, there has been only one case of metaplastic breast carcinoma associated with NF1. Curiously, in our case the oral metastasis corresponded to sarcomatous component of metaplastic breast carcinoma.
authors.affiliation: Stomatology Department, A.C. Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 São Paulo, SP, Brazil.
authors.forename: Ana Paula Molina
authors.initials: AP
authors.lastname: Vivas
authors.affiliation: Stomatology Department, University of São Paulo, Avenida Professor Lineu Prestes 2227, 05508-000 São Paulo, SP, Brazil.
authors.forename: Luana Eschholz
authors.initials: LE
authors.lastname: Bomfin
authors.affiliation: Pathology Department, A.C. Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 São Paulo, SP, Brazil.
authors.forename: Clovis Antonio Lopes
authors.initials: CA
authors.lastname: Pinto
authors.affiliation: Clinical Oncology Department, A.C. Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 São Paulo, SP, Brazil.
authors.forename: Ulisses Ribaldo
authors.initials: UR
authors.lastname: Nicolau
authors.affiliation: Stomatology Department, A.C. Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 São Paulo, SP, Brazil ; Stomatology Department, University of São Paulo, Avenida Professor Lineu Prestes 2227, 05508-000 São Paulo, SP, Brazil.
authors.forename: Fabio Abreu
authors.initials: FA
authors.lastname: Alves