title: Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis.
abstract: OBJECTIVE
  Candida albicans is a common fungal infection and is commensal in 40-65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis.
  
  
  METHODS
  Of the 12 patients with denture stomatitis treated for 14 days, six used Clot-SRV (study group) and six clotrimazole troches (control). The patients were instructed to use Clot-SRV (50 mg of clotrimazole) once a day, and the control group was instructed to use five troches of 10 mg clotrimazole/day. Microbiological samples were obtained from saliva, buccal mucosa, palate, and denture. The degree of erythema was recorded at three time points, and subjective opinions noted using a questionnaire.
  
  
  RESULTS
  At the end of the study, the control group had relatively more cases of erythema on all examined surfaces; patients who applied the Clot-SRV had significantly lower levels of candida on the denture surfaces and in saliva, and had better compliance to the medication.
  
  
  CONCLUSIONS
  The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes.
authors.affiliation: Department of Oral Medicine, School of Dental Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel, rakefetc@hadassah.org.il.
authors.forename: Rakefet
authors.initials: R
authors.lastname: Czerninski
authors.forename: Anna
authors.initials: A
authors.lastname: Pikovsky
authors.forename: Irith
authors.initials: I
authors.lastname: Gati
authors.forename: Michael
authors.initials: M
authors.lastname: Friedman
authors.forename: Doron
authors.initials: D
authors.lastname: Steinberg
mesh_terms: D000368:Aged; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002180:Candidiasis, Oral / Q000188:drug therapy*; D003022:Clotrimazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008875:Middle Aged; D011817:Rabbits
chemical_list: D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D003022:Clotrimazole