title: Supramolecular cyclodextrin pseudorotaxane hydrogels: a candidate for sustained release?
abstract: In this work, PEO-α-CD pseudorotaxane hydrogels were prepared. The gels were loaded with proteins, BSA and lysozyme, representing proteins with different molecular weights. The kinetics of protein release was studied. Factors such as PEO concentration, protein concentration and exposed surface area of the gels were investigated to understand their effects on the release of the encapsulated cargo. Erosion of the gel surface appeared to be the dominant factor for release of the proteins. Fitting the data to various models supported our hypothesis that the mechanism of release was primarily erosion-driven as the data was best described by zero order, power law and Hopfenberg model. The linear relationship between the amount of mass loss and time establishes the erosion of the polymer gel matrix to be the key factor for drug release.
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore.
authors.forename: Pei Lin
authors.initials: PL
authors.lastname: Chee
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore.
authors.forename: Ankshita
authors.initials: A
authors.lastname: Prasad
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Fang
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore.
authors.forename: Cally
authors.initials: C
authors.lastname: Owh
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore.
authors.forename: Valerie Jing Jing
authors.initials: VJ
authors.lastname: Yeo
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore; Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore; Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore. Electronic address: XianJun_Loh@scholars.a-star.edu.sg.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D008962:Models, Theoretical; D008970:Molecular Weight; D009113:Muramidase / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry; D043862:Rotaxanes / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003505:Cyclodextrins; D003692:Delayed-Action Preparations; D020100:Hydrogels; D043862:Rotaxanes; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D009113:Muramidase
keywords: Biomaterials; Drug release; Hydrogel; Kinetics; PEO