title: In-hospital and 12-month outcomes after acute coronary syndrome treatment in patients aged<40 years of age (from the Polish Registry of Acute Coronary Syndromes).
abstract: We aimed to compare the characteristics and in-hospital and 12-month outcomes in patients aged>40 and <40 years with acute coronary syndrome. The analysis involved 789 patients aged<40 years and 63,057 patients aged≥40 years enrolled in the ongoing Polish Registry of Acute Coronary Syndromes from October 2003 to December 2009. Patients aged<40 years with acute coronary syndrome differed from older patients in their clinical characteristics, treatment, and clinical outcome. The older patients more frequently had pulmonary edema (2.9% vs 0.4%, p<0.0001) and cardiogenic shock (4.7% vs 2.8%, p=0.011) on admission. For the younger patients, coronary angiography and percutaneous coronary intervention were performed more often (71.5% vs 60.5%, p<0.0001 and 51.5% vs 47.7%, p=0.04, respectively). The younger patients had a lower mortality rate than the older patients during hospitalization (1.5% vs 5.2%, p<0.0001) and during 12-month follow-up period (4.1% vs 13.4%, p<0.0001). Multivariate analysis revealed that age<40 years was one of the strongest factors associated with lower mortality during the 12 months after discharge (hazard ratio 0.42, 95% confidence interval 0.29 to 0.62, p<0.0001). In conclusion, younger patients had more favorable in-hospital and 1-year outcomes than older patients, and the age<40 years was revealed to be one of the strongest factors associated with lower mortality during the 1-year follow-up.
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland. Electronic address: przemyslaw.t@wp.pl.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Trzeciak
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Gierlotka
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gąsior
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Osadnik
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Hawranek
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lekston
authors.affiliation: Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Marian
authors.initials: M
authors.lastname: Zembala
authors.affiliation: Third Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Lech
authors.initials: L
authors.lastname: Poloński
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000601:surgery; D000328:Adult; D017023:Coronary Angiography; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011044:Poland / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome