title: Evaluation of the serum zinc level in erosive and non-erosive oral lichen planus.
abstract: BACKGROUND
  Lichen planus is a chronic inflammatory immunologic-based disease involving skin and mucosa. This disease is generally divided into two categories: erosive and non-erosive. Many etiologic factors are deliberated regarding the disease; however, the disorders of immune system and the role of cytotoxic T-lymphocytes and monocytes are more highlighted. Zinc is an imperative element for the growth of epithelium and its deficiency induces the cytotoxic activity of T-helper2 cells, which seems to be associated with lichen planus.
  
  
  OBJECTIVE
  This study was aimed to evaluate the levels of serum zinc in erosive and non-erosive oral lichen planus (OLP) and to compare it with the healthy control group to find out any feasible inference.
  
  
  METHODS
  A total of 22 patients with erosive oral lichen planus, 22 patients with non erosive OLP and 44 healthy individuals as the control group were recruited in this descriptive-comparative study. All the participants were selected from the referees to the department of oral medicine, school of dentistry, Tabriz University of Medical Sciences. Serum zinc level was examined for all the individuals with liquid-stat kit (Beckman Instruments Inc.; Carlsbad, CA). Data were analyzed by adopting the ANOVA and Tukey tests, using SPSS 16 statistical software.
  
  
  RESULTS
  The mean age of patients with erosive and non-erosive LP was 41.7 and 41.3 years, respectively. The mean age of the healthy control group was 34.4 years .The mean serum zinc levels in the erosive and non erosive lichen planus groups and control groups were 8.3 (1.15), 11.15 (0.92) and 15.74 (1.75) μg/dl respectively. The difference was statistically significant (p< 0.05).
  
  
  CONCLUSIONS
  The serum zinc levels were decreased in patients with erosive oral lichen planus. This finding may probably indicate the promising role of zinc in development of oral lichen planus.
authors.affiliation: Dept. of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Gholizadeh
authors.affiliation: Dept. of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mehdipour
authors.affiliation: Dept. of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Najafi
authors.affiliation: Dept. of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Bahramian
authors.affiliation: Dept. of Oral Radiology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Garjani
authors.affiliation: Dept. of Pediatric Oncology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Khoeini Poorfar
keywords: Lichen Planus; T helper; Zinc