title: Segmental versus extended resection for sporadic colorectal cancer in young patients.
abstract: OBJECTIVE
  Guidelines on the management of colon cancer state that extensive colectomy should be "considered" for patients of young age (<50). This study aimed to compare the risk of metachronous cancer, overall recurrence and mortality between segmental and extended colon resections in patients under the age of 50 with sporadic CRC.
  
  
  METHODS
  We performed a retrospective review of patients age <50 undergoing surgery for CRC from 1991 to 2009. Patients were divided into two groups based on extent of resection: segmental versus extended. The primary outcomes analyzed were metachronous tumors, disease recurrence, and overall survival.
  
  
  RESULTS
  Two hundred seventy one patients underwent segmental resection and 30 underwent extended resection. 3.3% in the segmental resection group developed metachronous CRC versus 0% in the extended resection group (P = 0.61). There was no significant difference in the risk of recurrence or mortality for those who underwent a segmental resection compared to those with an extended resection. In a regression model, type of surgery was not an independent risk factor for recurrence or mortality.
  
  
  CONCLUSIONS
  Extended colectomy for sporadic CRC in patients younger than 50 does not improve disease-free or overall survival. Further study to determine if segmental resection is appropriate oncologic treatment is warranted.
authors.affiliation: Section of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Coen L
authors.initials: CL
authors.lastname: Klos
authors.forename: Grace
authors.initials: G
authors.lastname: Montenegro
authors.forename: Nida
authors.initials: N
authors.lastname: Jamal
authors.forename: Paul E
authors.initials: PE
authors.lastname: Wise
authors.forename: James W
authors.initials: JW
authors.lastname: Fleshman
authors.forename: Bashar
authors.initials: B
authors.lastname: Safar
authors.forename: Sekhar
authors.initials: S
authors.lastname: Dharmarajan
mesh_terms: D000328:Adult; D000367:Age Factors; D003082:Colectomy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012007:Rectum / Q000601:surgery; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: colectomy; oncology; outcome; proctectomy; proctocolectomy