title: Development of multi-organ involvement including a left atrial myxoma-like lesion in a patient with granulomatosis with polyangiitis.
abstract: A 76-year-old woman suffering from granulomatosis with polyangitis (GPA) developed organizing pneumonia with positive antineutrophil cytoplasmic antibodies and microscopic hematuria. Prednisolone improved the hematuria and radiological findings; however, after tapering the dose of prednisolone, a posterior left atrial wall mass was detected in association with a fever. Both regressed spontaneously, although secretory otitis media and sinusitis were noted; the resected sinusitis specimen exhibited vasculitis highly suggestive of GPA. The clinical picture of GPA with multi-organ involvement can vary. Recognizing the various manifestations of GPA is therefore necessary in order to provide an appropriate diagnosis and disease management.
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishiguro
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Eriko
authors.initials: E
authors.lastname: Kawate
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Takaku
authors.forename: Naho
authors.initials: N
authors.lastname: Kagiyama
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D003937:Diagnosis, Differential; D004452:Echocardiography; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006331:Heart Diseases / Q000175:diagnosis* / Q000209:etiology; D006338:Heart Neoplasms / Q000175:diagnosis*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D009232:Myxoma / Q000175:diagnosis*; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D011239:Prednisolone