title: Oxidative stress, mitochondrial dysfunction and the mitochondria theory of aging.
abstract: Aging is characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-associated diseases and death. One potential cause of aging is the progressive accumulation of dysfunctional mitochondria and oxidative damage with age. Considerable efforts have been made in our understanding of the role of mitochondrial dysfunction and oxidative stress in aging and age-associated diseases. This chapter outlines the interplay between oxidative stress and mitochondrial dysfunction, and discusses their impact on senescence, cell death, stem cell function, age-associated diseases and longevity.
authors.affiliation: Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass., USA.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Kong
authors.forename: Sally E
authors.initials: SE
authors.lastname: Trabucco
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D016923:Cell Death / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D004272:DNA, Mitochondrial / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000503:physiopathology; D008136:Longevity; D008928:Mitochondria / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species