title: SOX11 as a minimal residual disease marker for Mantle cell lymphoma.
abstract: Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patient courses we validated the expression of SOX11 using t(11;14) and demonstrated positive correlation of SOX11 and t(11;14) levels. To the best of our knowledge this is the first report stating that quantification of SOX11 can be used as an minimal residual disease marker equal to the key translocation t(11;14) in MCL.
authors.affiliation: Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Anita Tranberg
authors.initials: AT
authors.lastname: Simonsen
authors.affiliation: Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Camilla Darum
authors.initials: CD
authors.lastname: Sørensen
authors.affiliation: Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Lene Hyldahl
authors.initials: LH
authors.lastname: Ebbesen
authors.affiliation: Department of Hematology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Julie Støve
authors.initials: JS
authors.lastname: Bødker
authors.affiliation: Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Hans Herluf Nørregaard
authors.initials: HH
authors.lastname: Bentzen
authors.affiliation: Department of Hematology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: nyvold@ki.au.dk.
authors.forename: Charlotte Guldborg
authors.initials: CG
authors.lastname: Nyvold
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D055751:SOXC Transcription Factors / Q000502:physiology*; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors
keywords: MCL; MRD; Mantle cell lymphoma; Minimal residual disease; SOX11; qPCR; t(11 ;14)