title: Is Lys-Nɛ-acetylation the next big thing in post-translational modifications?
abstract: Lys-N(ɛ)-acetylation (PKA) has recently ascended from a post-translational modification (PTM) of limited distribution to one approaching the abundance of O-phosphorylation. Thousands of KAC proteins have been identified in Archaea, bacteria, and Eukarya, and the KAC system of acetyltransferases, deacetylases, and binding proteins is superficially comparable with the kinases, phosphatases, and phospho- (P-)protein binding-proteins of O-phosphorylation. Herein, we describe recent results and compare several aspects of these two major systems of PTM in plants.
authors.affiliation: Division of Biochemistry, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA; Interdisciplinary Plant Group, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA.
authors.forename: R Shyama Prasad
authors.initials: RS
authors.lastname: Rao
authors.affiliation: Division of Biochemistry, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA; Interdisciplinary Plant Group, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Thelen
authors.affiliation: Division of Biochemistry, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA; Interdisciplinary Plant Group, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA; Plant Genetics Research Unit, USDA, Agricultural Research Service, University of Missouri, Columbia, MO 65211, USA. Electronic address: Jan.Miernyk@ars.usda.gov.
authors.forename: Ján A
authors.initials: JA
authors.lastname: Miernyk
mesh_terms: D000107:Acetylation; D018506:Gene Expression Regulation, Plant / Q000502:physiology*; D018745:Genome, Plant; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*
chemical_list: D010940:Plant Proteins
keywords: acetylome; acetyltransferase; posttranslational modification; regulation; signaling