title: Hypothermia and neonatal encephalopathy.
abstract: Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. Infants selected for cooling must meet the criteria outlined in published clinical trials. The implementation of cooling needs to be performed at centers that have the capability to manage medically complex infants. Because the majority of infants who have neonatal encephalopathy are born at community hospitals, centers that perform cooling should work with their referring hospitals to implement education programs focused on increasing the awareness and identification of infants at risk for encephalopathy, and the initial clinical management of affected infants.
authors.forename: Lu-Ann
authors.initials: LA
authors.lastname: Papile
authors.forename: Jill E
authors.initials: JE
authors.lastname: Baley
authors.forename: William
authors.initials: W
authors.lastname: Benitz
authors.forename: James
authors.initials: J
authors.lastname: Cummings
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Carlo
authors.forename: Eric
authors.initials: E
authors.lastname: Eichenwald
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
authors.forename: Richard A
authors.initials: RA
authors.lastname: Polin
authors.forename: Rosemarie C
authors.initials: RC
authors.lastname: Tan
authors.forename: Kasper S
authors.initials: KS
authors.lastname: Wang
mesh_terms: D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D003299:Cooperative Behavior; D005500:Follow-Up Studies; D006764:Hospitals, Community; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000151:congenital* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D033183:Interdisciplinary Communication; D016032:Randomized Controlled Trials as Topic; D012017:Referral and Consultation; D018570:Risk Assessment; D015996:Survival Rate