title: Distribution of semduramicin in hen eggs and tissues after administration of cross-contaminated feed.
abstract: Semduramicin is an ionophore coccidiostat used in the poultry industry as a feed additive. Cross-contamination of feeds for non-target animals with semduramicin is unavoidable. However, it is not known whether undesirable residues of semduramicin may occur in food after cross-contaminated feed is administered to animals. The aim of the work was to determine the levels of semduramicin in hen eggs (yolks and albumen) and tissues (liver, muscle, spleen, gizzard, ovarian yolks and ovaries) after administration of feed contaminated with 0.27 mg kg(-1) of this coccidiostat. The residues were determined using LC-MS/MS. The distribution pattern confirmed the high lipophilicity of semduramicin. Residues were found mainly in egg yolks (28.8 µg kg(-1)), ovarian yolks (19.5 µg kg(-1)) and liver (2.57 µg kg(-1)), while hens' muscle was free from semduramicin (LOD = 0.1 µg kg(-1)). Among edible tissues, the maximum level (2 µg kg(-1)) was exceeded only in the liver.
authors.affiliation: a Department of Pharmacology and Toxicology , National Veterinary Research Institute , Pulawy , Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Olejnik
authors.forename: Teresa
authors.initials: T
authors.lastname: Szprengier-Juszkiewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Jedziniak
mesh_terms: D000818:Animals; D002645:Chickens; D003049:Coccidiostats / Q000032:analysis / Q000493:pharmacokinetics*; D004350:Drug Residues / Q000032:analysis / Q000493:pharmacokinetics; D004531:Eggs / Q000032:analysis*; D005260:Female; D005506:Food Contamination; D009550:Nigericin / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D003049:Coccidiostats; C072941:semduramicin; D009550:Nigericin
keywords: distribution; eggs; feed cross-contamination; residues; semduramicin; tissues