title: Bioactive lipids and the control of Bax pro-apoptotic activity.
abstract: Lipids are key regulators of cell physiology through the control of many aspects of cellular life and survival. In particular, lipids have been implicated at different levels and through many different mechanisms in the cell death program called apoptosis. Here, we discuss the action of lipids in the regulation of the activation and the integration of Bax into the mitochondrial outer membrane, a key pro-apoptotic member of the BCL-2 family. We describe how, during apoptosis, lipids can act simultaneously or in parallel as receptors or ligands for Bax to stimulate or inhibit its pro-death activity.
authors.affiliation: 1] Centre de Recherche en Cancérologie Nantes Angers, Nantes, France [2] Université de Nantes, Nantes, France.
authors.forename: V
authors.initials: V
authors.lastname: Mignard
authors.affiliation: 1] Centre de Recherche en Cancérologie Nantes Angers, Nantes, France [2] Université de Nantes, Nantes, France [3] Institut de Cancérologie de l'Ouest, Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Lalier
authors.affiliation: 1] Centre de Recherche en Cancérologie Nantes Angers, Nantes, France [2] Université de Nantes, Nantes, France [3] Institut de Cancérologie de l'Ouest, Nantes, France.
authors.forename: F
authors.initials: F
authors.lastname: Paris
authors.affiliation: 1] Centre de Recherche en Cancérologie Nantes Angers, Nantes, France [2] Université de Nantes, Nantes, France [3] Institut de Cancérologie de l'Ouest, Nantes, France.
authors.forename: F M
authors.initials: FM
authors.lastname: Vallette
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: C494826:BAX protein, human; D008563:Membrane Lipids; D051028:bcl-2-Associated X Protein