title: Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?
abstract: OBJECTIVE
  Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism.
  
  
  METHODS
  Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS.
  
  
  RESULTS
  TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups.
  
  
  CONCLUSIONS
  Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.
authors.affiliation: 1 Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Feridun
authors.initials: F
authors.lastname: Bulbul
authors.affiliation: 1 Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Virit
authors.affiliation: 1 Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Gokay
authors.initials: G
authors.lastname: Alpak
authors.affiliation: 1 Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Unal
authors.affiliation: 2 Department of Psychiatry, School of Medicine, Dicle University, Dicle, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bulut
authors.affiliation: 2 Department of Psychiatry, School of Medicine, Dicle University, Dicle, Turkey.
authors.forename: Mehmet Cemal
authors.initials: MC
authors.lastname: Kaya
authors.affiliation: 3 Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Altindag
authors.affiliation: 4 Department of Biochemistry, School of Medicine, Harran University, Harran, Turkey.
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.affiliation: 3 Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Haluk A
authors.initials: HA
authors.lastname: Savas
mesh_terms: D000328:Adult; D015415:Biomarkers; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011618:Psychotic Disorders / Q000097:blood* / Q000175:diagnosis; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers