title: Anti-carbonic anhydrase II antibodies in end-stage renal disease patients.
abstract: OBJECTIVE
  The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine.
  
  
  METHODS
  Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects.
  
  
  RESULTS
  The CA II autoantibody titers in the ESRD group (0.170 ± 0.237) were significantly higher than those in the control group (0.079 ± 0.032; p = 0.035). MDA and ghrelin levels were also significantly higher in the ESRD group (p < 0.001). A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers (r = 0.287, p = 0.028 and r = -0.278, p = 0.032, respectively).
  
  
  CONCLUSIONS
  In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti-CA II antibodies could be involved in the pathogenesis of ESRD.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Menteşe
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Sümer
authors.forename: Fahri
authors.initials: F
authors.lastname: Uçar
authors.forename: Diler
authors.initials: D
authors.lastname: Us Altay
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001786:Blood Glucose; D001806:Blood Urea Nitrogen; D024402:Carbonic Anhydrase II / Q000276:immunology*; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000276:immunology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D054439:Ghrelin; D008315:Malondialdehyde; D003404:Creatinine; D024402:Carbonic Anhydrase II