title: Oral anticoagulation and vitamin K deficiency.
abstract: A 61-year old woman with atrial fibrillation developed macrohaematuria during anticoagulant treatment with a direct oral factor Xa inhibitor for stroke prevention. Abnormal results of coagulation assays were first interpreted as an effect of the anticoagulant. However, upon further testing diagnosis of vitamin K deficiency was established. After vitamin K supplementation, coagulation tests normalized and macrohaematuria disappeared. Treatment with broad spectrum antibiotics for urinary tract infection was finally established as a rare cause for vitamin K deficiency in the patient.
authors.affiliation: Prof. Dr. Sabine Eichinger-Hasenauer, Dept. of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Wien, Austria, E-mail: sabine.eichinger@meduniwien.ac.at.
authors.forename: S
authors.initials: S
authors.lastname: Eichinger
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000925:Anticoagulants / Q000008:administration & dosage; D005189:False Positive Reactions; D005260:Female; D006417:Hematuria / Q000139:chemically induced* / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D010644:Phenprocoumon / Q000008:administration & dosage*; D016896:Treatment Outcome; D014812:Vitamin K / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D014813:Vitamin K Deficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D014812:Vitamin K; D010644:Phenprocoumon
keywords: Phenprocoumon; bleeding; direct oral anticoagulant; haematuria; vitamin K deficiency