title: Obesity, inflammation, and lung injury (OILI): the good.
abstract: Obesity becomes pandemic, predisposing these individuals to great risk for lung injury. In this review, we focused on the anti-inflammatories and addressed the following aspects: adipocytokines and obesity, inflammation and other mechanisms, adipocytokines and lung injury in obesity bridged by inflammation, and potential therapeutic targets. To sum up, the majority of evidence supported that adiponectin, omentin, and secreted frizzled-related protein 5 (SFRP5) were reduced significantly in obesity, which is associated with increased inflammation, indicated by increase of TNF α and IL-6, through activation of toll-like receptor (TLR4) and nuclear factor light chain κ B (NF- κ B) signaling pathways. Administration of these adipocytokines promotes weight loss and reduces inflammation. Zinc-α 2-glycoprotein (ZAG), vaspin, IL-10, interleukin-1 receptor antagonist (IL-1RA), transforming growth factor β (TGF-β1), and growth differentiation factor 15 (GDF15) are also regarded as anti-inflammatories. There were controversial reports. Furthermore, there is a huge lack of studies for obesity related lung injury. The effects of adiponectin on lung transplantation, asthma, chronic obstructive pulmonary diseases (COPD), and pneumonia were anti-inflammatory and protective in lung injury. Administration of IL-10 agonist reduces mortality of acute lung injury in rabbits with acute necrotizing pancreatitis, possibly through inhibiting proinflammation and strengthening host immunity. Very limited information is available for other adipocytokines.
authors.affiliation: Department of Anesthesiology, University at Buffalo, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA ; Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D052242:Adiponectin / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005136:Eye Proteins / Q000502:physiology; D058851:GPI-Linked Proteins / Q000502:physiology; D055436:Growth Differentiation Factor 15 / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D016753:Interleukin-10 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D037102:Lectins / Q000502:physiology; D055370:Lung Injury / Q000150:complications / Q000503:physiopathology*; D008565:Membrane Proteins / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000502:physiology; D029589:Seminal Plasma Proteins / Q000502:physiology; D015843:Serpins / Q000502:physiology; D015398:Signal Transduction; D051197:Toll-Like Receptor 4 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D000090203:Zn-Alpha-2-Glycoprotein; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D052242:Adiponectin; D016207:Cytokines; D005136:Eye Proteins; D058851:GPI-Linked Proteins; D055436:Growth Differentiation Factor 15; D016753:Interleukin-10; D015850:Interleukin-6; D037102:Lectins; D008565:Membrane Proteins; D016328:NF-kappa B; D017472:Receptors, Interleukin-1; D029589:Seminal Plasma Proteins; D015843:Serpins; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D000090203:Zn-Alpha-2-Glycoprotein; C526140:GDF15 protein, human; C508600:IL6 protein, human; C432397:ITLN1 protein, human; C507339:SERPINA12 protein, human; C118511:SFRP5 protein, human; D000094742:Secreted Frizzled-Related Proteins; C495345:TLR4 protein, human