title: DMRT1 keeps masculinity intact.
abstract: It is generally assumed that sexual phenotypes formed in utero are permanently established and do not require maintenance. In this issue of Developmental Cell, Minkina et al. (2014) now show that the transcriptional regulator DMRT1 actively prevents postnatal male-to-female sex reversal by blocking the activation of retinoid-signaling-dependent feminization genes.
authors.affiliation: Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: tony.defalco@cchmc.org.
authors.forename: Tony
authors.initials: T
authors.lastname: DeFalco
mesh_terms: D000818:Animals; D054338:Cell Transdifferentiation / Q000187:drug effects*; D005260:Female; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000166:cytology*; D012176:Retinoids / Q000494:pharmacology*; D012708:Sertoli Cells / Q000166:cytology*; D013737:Testis / Q000166:cytology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C110547:DMRT1 protein; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; C498893:Foxl2 protein, mouse; D012176:Retinoids; D014157:Transcription Factors