title: Effects of reflux laryngitis on non-nutritive swallowing in newborn lambs.
abstract: Reflux laryngitis in infants may be involved not only in laryngeal disorders, but also in disorders of cardiorespiratory control through its impact on laryngeal function. Our objective was to study the effect of reflux laryngitis on non-nutritive swallowing (NNS) and NNS-breathing coordination. Two groups of six newborn lambs, randomized into laryngitis and control groups, were surgically instrumented for recording states of alertness, swallowing and cardiorespiratory variables without sedation. A mild to moderate reflux laryngitis was induced in lambs from the experimental group. A significant decrease in the number of NNS bursts and apneas was observed in the laryngitis group in active sleep (p=0.03). In addition, lower heart and respiratory rates, as well as prolonged apnea duration (p<0.0001) were observed. No physiologically significant alterations in NNS-breathing coordination were observed in the laryngitis group. We conclude that a mild to moderate reflux laryngitis alters NNS burst frequency and autonomous control of cardiac activity and respiration in lambs.
authors.affiliation: Department of Surgery, ENT Division, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4.
authors.forename: Simon
authors.initials: S
authors.lastname: Brisebois
authors.affiliation: Department of Pediatrics, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4; Department of Physiology, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Samson
authors.affiliation: Department of Surgery, ENT Division, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4.
authors.forename: Pierre-Hugues
authors.initials: PH
authors.lastname: Fortier
authors.affiliation: Department of Pathology, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4.
authors.forename: Alexandre A
authors.initials: AA
authors.lastname: Doueik
authors.affiliation: Department of Pediatrics, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4; Department of Physiology, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Carreau
authors.affiliation: Department of Pediatrics, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4; Department of Physiology, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4; Department of Surgery, ENT Division, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke (QC), Canada J1H 5N4. Electronic address: Jean-Paul.Praud@USherbrooke.ca.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Praud
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001049:Apnea / Q000503:physiopathology; D003679:Deglutition / Q000502:physiology*; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology; D007820:Laryngeal Mucosa / Q000473:pathology; D007827:Laryngitis / Q000473:pathology / Q000503:physiopathology*; D057045:Laryngopharyngeal Reflux / Q000473:pathology / Q000503:physiopathology*; D011897:Random Allocation; D012119:Respiration; D034561:Sheep, Domestic; D012890:Sleep / Q000502:physiology*
keywords: Lambs; Non-nutritive swallowing–breathing coordination; Reflux laryngitis