title: Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone.
abstract: An original design and synthesis of fluorescent ligands for melatonin receptor studies is presented and consists in the fusion of the endogenous ligand with the fluorescent BODIPY core. Probes I-IV show high affinities for MT1 and MT2 melatonin receptors and exhibit fluorescence properties compatible with cell observation.
authors.affiliation: Université d'Orléans , CNRS, ICOA, UMR 7311, F-45067 Orleans, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Thireau
authors.affiliation: Université d'Orléans , CNRS, ICOA, UMR 7311, F-45067 Orleans, France.
authors.forename: Justine
authors.initials: J
authors.lastname: Marteaux
authors.affiliation: Unité de Recherches et Découvertes en Neurosciences, Institut de Recherches Servier , 78290 Croissy-sur-Seine, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Delagrange
authors.affiliation: Technologie SERVIER , 27 rue Eugéne Vignat, 45000 Orléans, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Lefoulon
authors.affiliation: UMR INRA-CNRS 7247-Univ. Tours-IFCE, PRC, Centre INRA de Tours , 37380 Nouzilly, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Dufourny
authors.affiliation: Université d'Orléans , CNRS, ICOA, UMR 7311, F-45067 Orleans, France.
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet
authors.affiliation: Université d'Orléans , CNRS, ICOA, UMR 7311, F-45067 Orleans, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Suzenet
keywords: BODIPY; GPCRs; fluorescence; melatonin; molecular probes