title: GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.
abstract: Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.
authors.affiliation: Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina. Business School of Xiangtan University, Hunan, China.
authors.forename: Huashuai
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Ni
authors.affiliation: Renmin University of China, Beijing, China.
authors.forename: Rongping
authors.initials: R
authors.lastname: Ruan
authors.affiliation: National University of Singapore.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: BGI-Shenzhen, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Nie
authors.affiliation: School of Business, Nanjing University, China.
authors.forename: Lingguo
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Life Sciences, Peking University, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tao
authors.affiliation: School of Life Sciences, Peking University, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gu
authors.affiliation: Population Research Institute, Duke University, Durham, North Carolina.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Land
authors.affiliation: Population Research Institute, Duke University, Durham, North Carolina.
authors.forename: Anatoli
authors.initials: A
authors.lastname: Yashin
authors.affiliation: Unit of Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense.
authors.forename: Qihua
authors.initials: Q
authors.lastname: Tan
authors.affiliation: National Institute of Geriatrics, Beijing Hospital, Ministry of Health of China, Beijing, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
authors.affiliation: BGI-Shenzhen, China. Department of Biomedicine, Aarhus University, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Bolund
authors.affiliation: BGI-Shenzhen, China. James D. Watson Institute of Genome Sciences, Hangzhou, China. Princess Al-Jawhara Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.affiliation: Center for Human Genetics, Medical Center, Duke University, Durham, North Carolina.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hauser
authors.affiliation: Department of Human Welfare, Okinawa International University, Ginowan, Japan. Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu.
authors.forename: D Craig
authors.initials: DC
authors.lastname: Willcox
authors.affiliation: Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Willcox
authors.affiliation: Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Tian
authors.affiliation: Max Planck Institute for Demographic Research, Rostock, Germany.
authors.forename: James W
authors.initials: JW
authors.lastname: Vaupel
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000208:ethnology / Q000235:genetics / Q000517:prevention & control*; D004327:Drinking Behavior; D019317:Evidence-Based Medicine; D005260:Female; D000071161:Forkhead Box Protein O1; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics*; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013662:Tea
chemical_list: C085126:FOXO1 protein, human; C499517:FOXO3 protein, human; D000071161:Forkhead Box Protein O1; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D013662:Tea
keywords: Cognitive disability; FOXO genotypes; GxE interactions; Oldest old.; Tea drinking