title: Multiple endocrine neoplasia type IIa associated with Cushing's syndrome.
abstract: Multiple Endocrine Neoplasia type IIa (MEN IIa) is an autosomal dominant syndrome characterized by pheochromocytoma, medullary thyroid carcinoma and hyperparathyroidism. Pheochromocytoma occurs in approximately 50% of patients with MEN IIa. This tumor has the capacity to produce ACTH ectopically and manifests as the Cushing syndrome, although it is very rare. We report a 26-year-old woman patient with severe muscle weakness, skin lesions in extremities, hypertension, and new onset diabetes whose laboratory findings included hypokalemia, metabolic alkalosis, high serum level of cortisol, metanephrine, normetanephrine, calcitonin and bilateral adrenal mass in computed tomography as the first clinical manifestations of an ACTH-secreting pheochromocytoma. In the patients with hypertension, new onset diabetes and hypokalemia, the Cushing syndrome and pheochromocytoma should always be ruled out.
authors.affiliation: Department of Internal Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.Aminmed30@gmail.com.
authors.forename: Shiva
authors.initials: S
authors.lastname: Borzouei
authors.affiliation: Department of Urology, Hamedan University of Medical Sciences, Hamedan, Iran.
authors.forename: Seyed Habib Allah
authors.initials: SH
authors.lastname: Mousavi Bahar
authors.affiliation: Student Research Committee, Hamedan University of Medical Sciences, Hamedan, Iran.
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Fereydouni
authors.affiliation: Cardiac Anesthesiologist, Hamedan University of Medical Sciences, Hamedan, Iran.
authors.forename: Seyed Ahmadreza
authors.initials: SA
authors.lastname: Salimbahrami
authors.affiliation: Nephrology and Urology Research Center,Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Taghipour
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000209:etiology*
chemical_list: D000324:Adrenocorticotropic Hormone