title: Multiple functions of hypoxia-regulated miR-210 in cancer.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processes including differentiation, cell proliferation, cell death, and tumorigenesis. Hypoxia, a common feature of tumor microenvironment, can induce a number of miRNAs expression. miRNA-210 (miR-210) is one of the hypoxia-regulated-miRNAs, which has been investigated extensively in cancer. However, paradoxically opposing results were documented regarding whether it is an oncogene or a tumor suppressor, and whether it is a positive or negative prognostic biomarker. In the present review, we focus on the following investigations of miR-210: 1) its functions of as an oncogene, 2) its functions as a tumor suppressor, 3) its functions in mitochondrial metabolism, and finally, the diagnostic and prognostic value of miR-210 in cancer researches.
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: Furong
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital, Shandong University, Jiyan Road 440, Jinan 250117, P,R, China. Baoshli@yahoo.com.
authors.forename: Li
authors.initials: L
authors.lastname: Baosheng
mesh_terms: D017209:Apoptosis; D015687:Cell Hypoxia; D049109:Cell Proliferation; D004260:DNA Repair; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics; D009857:Oncogenes
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs