title: Designing vaccines to neutralize effective toxin delivery by enterotoxigenic Escherichia coli.
abstract: Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens.
authors.affiliation: Division of Infectious Diseases, Washington University School of Medicine, 660 South Euclid Avenue; Saint Louis, MO 63110, USA. jflecken@wustl.edu.
authors.forename: James M
authors.initials: JM
authors.lastname: Fleckenstein
authors.affiliation: Molecular Microbiology and Microbiobial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue; Saint Louis, MO 63110, USA. asheikh@wustl.edu.
authors.forename: Alaullah
authors.initials: A
authors.lastname: Sheikh
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000627:therapeutic use; D001692:Biological Transport; D004403:Dysentery / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D054307:Enterotoxigenic Escherichia coli / Q000276:immunology* / Q000502:physiology; D004768:Enterotoxins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D022361:Escherichia coli Vaccines / Q000627:therapeutic use*; D054884:Host-Pathogen Interactions; D006801:Humans; D037521:Virulence Factors / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D057134:Antibodies, Neutralizing; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D022361:Escherichia coli Vaccines; D037521:Virulence Factors