title: Central blood pressure reflects left ventricular load, while brachial blood pressure reflects arterial damage.
abstract: OBJECTIVE
  The present study investigated whether brachial and central blood pressures have differential impact on the cardiovascular system in the general population.
  
  
  METHODS
  The study included 706 subjects (59 ± 10 years) who visited our hospital for a physical check-up. Brachial blood pressure and radial artery pressure waveforms were recorded using an automated device, and the pressure corresponding to the radial late systolic peak (SBP2) was taken as central blood pressure. The concentration of B-type natriuretic peptide and the intima-media thickness of the carotid artery were measured and a cross-sectional analysis was performed.
  
  
  RESULTS
  Brachial blood pressure was 128 ± 18/74 ± 12 (mean blood pressure, 92 ± 13) mmHg and SBP2 was 120 ± 19 mmHg. Although both brachial systolic blood pressure and SBP2 correlated with B-type natriuretic peptide in a univariate analysis, only SBP2 independently correlated with B-type natriuretic peptide after adjustment for possible factors. In contrast, brachial systolic blood pressure, but not SBP2, independently correlated with carotid artery intima-media thickness.
  
  
  CONCLUSIONS
  Central blood pressure is more closely associated with left ventricular load than brachial blood pressure, while brachial blood pressure is more strongly associated with vascular damage than central blood pressure.
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences , Nagoya , Japan.
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takase
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugiura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001795:Blood Pressure Determination; D001916:Brachial Artery / Q000502:physiology* / Q000503:physiopathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D016276:Ventricular Function
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: B-type natriuretic peptide; carotid arteries; intima-media thickness; target organ damage; ventricular load