title: Pathological Correlation between Number of Biopsies and Radical Surgery: Does It Make a Difference to Final Pathology?
abstract: OBJECTIVE
  To evaluate whether the number of biopsies performed via transrectal ultrasound (TRUS) accurately predicts pathological parameters such as Gleason sum, prostatic intraepithelial neoplasia and perineural invasion of the final prostatectomy specimen.
  
  
  METHODS
  The cohort consisted of 99 patients whom had undergone radical prostatectomy. Comparisons were made between the number of biopsies utilised and the presence of the pathological parameters from tissue at time of diagnosis and tissue from the final prostatectomy.
  
  
  RESULTS
  A significant difference was noted between Gleason sum, prostatic intraepithelial neoplasia and perineural invasion from tissue at time of diagnosis irrespective of the number of biopsies utilised and tissue from the radical specimen (p < 0.001, p < 0.001, p < 0.001 respectively). No difference was noted in the mean Gleason sum when 11-14 biopsies were utilised at TRUS and the Gleason sum from the radical specimen.
  
  
  CONCLUSIONS
  We have demonstrated that the number of biopsies utilised at time of TRUS for diagnosis predicts the accuracy of pathological parameters in the final radical prostatectomy specimen. We believe that 11-14 biopsies should be utilised at time of TRUS as this allows a higher accuracy in the Gleason sum and therefore allows optimum treatment plans to be devised.
authors.affiliation: Unit of Experimental Therapeutics, Institute of Cancer, College of MVLS, University of Glasgow, Western Infirmary, Glasgow, UK.
authors.forename: Tahir
authors.initials: T
authors.lastname: Qayyum
authors.affiliation: Unit of Experimental Therapeutics, Institute of Cancer, College of MVLS, University of Glasgow, Western Infirmary, Glasgow, UK.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Willder
authors.affiliation: School of Medicine, College of MVLS, University of Glasgow, Royal Infirmary, Glasgow, UK.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Horgan
authors.affiliation: Unit of Experimental Therapeutics, Institute of Cancer, College of MVLS, University of Glasgow, Western Infirmary, Glasgow, UK.
authors.forename: Joanne
authors.initials: J
authors.lastname: Edwards
authors.affiliation: Department of Urology, Royal Infirmary, Glasgow, UK.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Underwood
keywords: Prostate cancer; Radical prostatectomy; Transrectal ultrasound biopsy