title: Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1.
abstract: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant virus in vitro and immunogenicity in inducing neutralizing antibody against PPR in goats. Vaccination with one dose of rPPRV/VP1 induced FMDV neutralizing antibody in goats and protected them from challenge with virulent FMDV. Our results suggest that the recombinant PPRV expressing the FMDV VP1 protein is a potential dual live vectored vaccine against PPRV and FMDV.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Yin
authors.forename: Weiye
authors.initials: W
authors.lastname: Chen
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Hu
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wen
authors.forename: Xijun
authors.initials: X
authors.lastname: Wang
authors.forename: Jinying
authors.initials: J
authors.lastname: Ge
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Yin
authors.forename: Haibing
authors.initials: H
authors.lastname: Zhi
authors.affiliation: Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China. xiachun@cau.edu.cn.
authors.forename: Chun
authors.initials: C
authors.lastname: Xia
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Bu
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D005536:Foot-and-Mouth Disease / Q000517:prevention & control* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000235:genetics / Q000276:immunology*; D015511:Goat Diseases / Q000517:prevention & control* / Q000821:virology; D006041:Goats; D007110:Immunity, Active / Q000187:drug effects; D009500:Neutralization Tests / Q000662:veterinary; D029021:Peste-des-Petits-Ruminants / Q000517:prevention & control* / Q000821:virology; D018107:Peste-des-petits-ruminants virus / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines