title: Allogenic cardiomyoblasts raised from human mesenchymal stem cells in the therapy of radiation cardiomyopathy and pericarditis: case report.
abstract: The use of triple systemic transplantation of cardiomyoblasts raised from the culture of allogenic bone marrow mesenchymal stem cells of a healthy donor according to the new medical technology licensed by Federal Service on Surveillance in Healthcare in the therapy of a patient with late radiation cardiomyopathy and radiation exudative pericarditis developed 45 years after radiation therapy for Hodgkin lymphoma. High efficiency of systemic transplantation of mesenchymal stem cells partially differentiated towards cardiomyocytes was demonstrated. The therapeutic effect persists for more than 2 years. Possible mechanisms of the therapeutic effect of this type of stem cells and the prospects of using cell therapy in the treatment of late radiation injuries of vital organs and tissues are discussed.
authors.affiliation: Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Kursova
authors.forename: A G
authors.initials: AG
authors.lastname: Konoplyannikov
authors.forename: S Sh
authors.initials: SSh
authors.lastname: Kal'sina
authors.forename: S B
authors.initials: SB
authors.lastname: Baboyan
mesh_terms: D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D002454:Cell Differentiation; D005720:Gamma Rays / Q000009:adverse effects; D006689:Hodgkin Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D008875:Middle Aged; D032386:Myoblasts, Cardiac / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D010493:Pericarditis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014463:Ultrasonography