title: Neurobehavioural analysis of developmental iron deficiency in Oreochromis aureus × Oreochromis niloticus.
abstract: The objective of this study was to examine the association between brain iron measurements of monoamine function and behavioural measurements of learning and memory. Male hybrid tilapias Oreochromis aureus × Oreochromis niloticus were fed either an iron-deficient (ID) diet or an iron-adequate (IA) diet for 8 weeks. The ID fishes showed significantly lower iron content in brain and decreasing learning and memory capacity. The fishes that showed increased learning and memory capacity had higher levels of iron and monoamine oxidase activity in brain. In addition, the results showed that learning and memory behaviours were related to monoamine (dopamine and noradrenaline) concentration in the brain. This suggests that iron can enhance learning and memory capacity in fishes and that the effect may have monoaminergic mediation in discrimination learning and memory tasks. The experimental data suggest that the properties and neural basis of learning and memory of teleosts are notably similar to those of land vertebrates.
authors.affiliation: Key Laboratory of Ecology and Environment Science in Guangdong Higher Education, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, College of Life Science, South China Normal University, Guangzhou 510631, China; Hainan Provincial Key Laboratory of Technology for Tropical Seawater Aquaculture, Hainan Provincial Fisheries Research Institute, Qionghai 570206, China.
authors.forename: L-R
authors.initials: LR
authors.lastname: Bai
authors.forename: A-L
authors.initials: AL
authors.lastname: Wang
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhao
authors.forename: Y-T
authors.initials: YT
authors.lastname: Miao
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000254:growth & development* / Q000502:physiology; D023681:Cichlids / Q000254:growth & development*; D004032:Diet / Q000662:veterinary; D004298:Dopamine / Q000502:physiology; D000090463:Iron Deficiencies; D007858:Learning; D008297:Male; D008568:Memory; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology
chemical_list: D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine
keywords: learning; memory; monoamine; tilapia