title: Relationship between serum soluble vascular adhesion protein-1 level and gastric cancer prognosis.
abstract: BACKGROUND
  Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion in a sialic acid-dependent manner. The prognostic importance of VAP-1 was determined in various human cancers. The aim of this study was to determine the relationship between VAP-1 and prognosis of gastric cancer.
  
  
  METHODS
  Serum of operable and metastatic gastric cancer patients was collected before treatment (surgery, radiotherapy, and/or chemotherapy). VAP-1 levels were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  A total of 86 gastric cancer patients (32 female, 54 male) were included in the study. Curative surgical treatment was performed in 54 (62.8%) patients. The mean serum VAP-1 level was 324.4 pg/ml and significantly higher in operable gastric cancer patients compared to metastatic gastric cancer patients (383.1 ± 173.5 vs. 225.2 ± 113.9 pg/ml; p < 0.001). When a cut-off value for VAP-1 of 218.8 pg/ml was determined by receiver operating characteristic (ROC) curves for presence of metastasis, sensitivity and specificity were 81.5 and 65.6%, respectively. Patients with decreased VAP-1 levels had a significantly poorer prognosis compared to patients with increased serum VAP-1 levels (median survival 8.2 vs. 23.5 months; p < 0.001). Multivariate analysis showed that VAP-1 is an independent prognostic factor of gastric cancer (odds ratio 2.3, 95% confidence interval 1.1-4.9; p = 0.032).
  
  
  CONCLUSIONS
  A low serum VAP-1 level may be an indicator of poor prognosis in gastric cancer. This study demonstrated that low serum VAP-1 levels are associated with poor prognosis in gastric cancer patients.
authors.affiliation: Department of Medical Oncology, School of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Muhammet A
authors.initials: MA
authors.lastname: Kaplan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kucukoner
authors.forename: Ali
authors.initials: A
authors.lastname: Inal
authors.forename: Zuhat
authors.initials: Z
authors.lastname: Urakci
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Ugur
authors.initials: U
authors.lastname: Firat
authors.forename: Muhsin
authors.initials: M
authors.lastname: Kaya
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Isikdogan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)