title: Dual pH-triggered multistage drug delivery systems based on host-guest interaction-associated polymeric nanogels.
abstract: The polymeric nanogels were constructed via host-guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China. gezs@ustc.edu.cn.
authors.forename: Minghui
authors.initials: M
authors.lastname: Zan
authors.forename: Junjie
authors.initials: J
authors.lastname: Li
authors.forename: Shizhong
authors.initials: S
authors.lastname: Luo
authors.forename: Zhishen
authors.initials: Z
authors.lastname: Ge
mesh_terms: D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000080385:Nanogels; D011108:Polymers; D047392:beta-Cyclodextrins; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine; C031215:betadex