title: Design, synthesis, and pharmacological evaluation of novel 2-(4-substituted piperazin-1-yl)1, 8 naphthyridine 3-carboxylic acids as 5-HT3 receptor antagonists for the management of depression.
abstract: 1, 8-naphthyridine-3-carboxylic acid analogs were synthesized and found to possess potential 5-HT3 receptor antagonism as well as antidepressant-like activity. Initially, 5-HT3 receptor antagonism of all the compounds was determined in the form of pA2 value against agonist 2-methyl 5-HT in longitudinal muscle-myenteric plexus preparation from guinea-pig ileum. Among all the compounds tested, compound 7a demonstrated most promising pA2 value of 7.6. Subsequently, all the compounds were evaluated for antidepressant activity using forced swim test and tail suspension test in mice. Compounds 7a, 7d, 7f, 7h, and 7i exhibited significant (p < 0.05) antidepressant-like activity as compound to vehicle-treated group. Importantly, none of the tested compound affected locomotor activity of mice at tested dose levels.
authors.affiliation: Department of Pharmacy, FD-III, Birla Institute of Technology & Science, Pilani, Rajasthan, 333 031, India.
authors.forename: Arghya K
authors.initials: AK
authors.lastname: Dhar
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Mahesh
authors.forename: Ankur
authors.initials: A
authors.lastname: Jindal
authors.forename: Thangaraj
authors.initials: T
authors.lastname: Devadoss
authors.forename: Shvetank
authors.initials: S
authors.lastname: Bhatt
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D015195:Drug Design; D006168:Guinea Pigs; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009287:Naphthyridines / Q000737:chemistry; D044406:Receptors, Serotonin, 5-HT3 / Q000737:chemistry* / Q000378:metabolism; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000928:Antidepressive Agents; D002264:Carboxylic Acids; D009287:Naphthyridines; D044406:Receptors, Serotonin, 5-HT3; D058831:Serotonin 5-HT3 Receptor Antagonists
keywords: 1,8-naphthyridine; 5-HT3 receptor antagonist; anti-depressant; forced swim test; tail suspension test