title: Thyroid disease and cognition.
abstract: Overt hypothyroidism and thyrotoxicosis are associated with significant decrements in mood and cognitive function, and therapy usually leads to improvement in these symptoms. In contrast, major affective or cognitive dysfunction is not typical of subclinical thyroid disease. Subtle deficits in specific cognitive domains (primarily working memory and executive function) likely exist in subclinical hypothyroidism and thyrotoxicosis, but these are unlikely to cause major problems in most patients. Patients with mild thyroid disease and significant distress related to mood or cognition most likely have independent diagnoses that should be evaluated and treated separately.
authors.affiliation: Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: samuelsm@ohsu.edu.
authors.forename: Mary H
authors.initials: MH
authors.lastname: Samuels
mesh_terms: D000339:Affect; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology; D006801:Humans; D009483:Neuropsychological Tests; D013959:Thyroid Diseases / Q000150:complications* / Q000523:psychology
keywords: Cognition; Hypothyroidism; Mood; Subclinical hypothyroidism; Subclinical thyrotoxicosis; Thyrotoxicosis