title: A new Methimazole sensor based on nanocomposite of CdS NPs-RGO/IL-carbon paste electrode using differential FFT continuous linear sweep voltammetry.
abstract: A Methimazole sensor was designed and constructed based on nanocomposite of carbon, ionic liquid, reduced graphene oxide (RGO) and CdS nanoparticles. The sensor signal was obtained by Differential FFT continuous linear sweep voltammetry (DFFTCLSV) technique. The potential waveform contains two sections, preconcentration potential and potential ramp. In this detection technique, after subtracting the background current from noise, the electrode response was calculated, based on partial and total charge exchanges at the electrode surface. The combination of RGO and CdS nanoparticles can catalyze the electron transfer, which outcomes of the amplification of the sensor signal. The result showed that the sensor response was proportional to the concentrations of Methimazole in the range of 2.0 to 300 nM, with a detection limit of 5.5×10(-10) M. The sensor showed good reproducibility, long-term of usage stability and accuracy. The characterization of the sensor surface was studied by atomic force Microscopy and Electrochemical Impedance Spectroscopy. Moreover, the proposed sensor exhibited good accuracy, and R.S.D value of 2.82%, and the response time of less than 7 s.
authors.affiliation: Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran; Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: norouzi@khayam.ut.ac.ir.
authors.forename: Parviz
authors.initials: P
authors.lastname: Norouzi
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India. Electronic address: vinodfcy@gmail.com.
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Gupta
authors.affiliation: Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.affiliation: Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran; Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ganjali
authors.affiliation: Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran; Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Farnoush
authors.initials: F
authors.lastname: Faridbod
mesh_terms: D013956:Antithyroid Agents / Q000032:analysis*; D019187:Cadmium Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D008713:Methimazole / Q000032:analysis*; D018625:Microscopy, Atomic Force; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*
chemical_list: C412621:1-butyl-3-methylimidazolium hexafluorophosphate; D013956:Antithyroid Agents; D019187:Cadmium Compounds; D007093:Imidazoles; D052578:Ionic Liquids; D010087:Oxides; D013440:Sulfides; C034939:cadmium sulfide; D008713:Methimazole; D002244:Carbon; D006108:Graphite
keywords: CdS nanoparticles; Differential FFT continuous linear sweep voltammetry; Ionic liquid; Methimazole; Reduced graphene oxide