title: Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds.
abstract: Performing actions with auditory consequences modulates the response in auditory cortex to otherwise identical stimuli passively heard. Such modulation has been suggested to occur through a corollary discharge sent from the motor cortex during voluntary actions. However, the relationship between the effector used to generate the sound, type of modulation and changes in perceptual sensitivity are unclear. Here we use functional magnetic resonance imaging on healthy subjects and demonstrate bilateral enhancement in the auditory cortex to self-generated versus externally generated sounds. Furthermore, we find that this enhancement is stronger when the sound-producing hand is contralateral to the auditory cortex. At the behavioural level, binaural hearing thresholds are lower for self-generated sounds and monaural thresholds are lower for sounds triggered by the hand ipsilateral to the stimulated ear. Together with functional connectivity analysis, our results suggest that a corollary discharge sent from active motor cortex enhances activity in the auditory cortex and increases perceptual sensitivity in a lateralized manner.
authors.affiliation: 1] School of Psychological Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel [2] Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Daniel
authors.initials: D
authors.lastname: Reznik
authors.affiliation: 1] Department of Communication Disorders, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel [2] Hearing, Speech, and Language Center, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Henkin
authors.affiliation: 1] School of Psychological Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel [2] Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Noa
authors.initials: N
authors.lastname: Schadel
authors.affiliation: 1] School of Psychological Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel [2] Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Roy
authors.initials: R
authors.lastname: Mukamel
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001309:Auditory Threshold / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009146:Music; D017397:Prefrontal Cortex / Q000502:physiology*; D055815:Young Adult