title: Reaction between (Z)-arylchlorooximes and α-isocyanoacetamides: a procedure for the synthesis of aryl-α-ketoamide amides.
abstract: (Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and important synthetic intermediates in organic chemistry.
authors.affiliation: Dipartimento di Farmacia, Università di Napoli "Federico II" , via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Giustiniano
authors.forename: Valentina
authors.initials: V
authors.lastname: Mercalli
authors.forename: Hilde
authors.initials: H
authors.lastname: Cassese
authors.forename: Salvatore
authors.initials: S
authors.lastname: Di Maro
authors.forename: Ubaldina
authors.initials: U
authors.lastname: Galli
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000593320:1,3-oxazol-2-oxime; D000577:Amides; D009570:Nitriles; D010080:Oxazoles; D010091:Oximes; C031594:2-cyanoacetamide