title: Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: a prospective study.
abstract: OBJECTIVE
  To compare outcomes of anterior corpus callosotomy (CCT) with anti-epileptic drugs (AEDs) treatment in school-aged children with Lennox-Gastaut syndrome (LGS).
  
  
  METHODS
  Sixty school-aged children with LGS were prospectively enrolled and divided into either the medicine or surgery group according the choice of the patients' caregivers. Cases in the medicine group were treated with multiple rational AEDs and patients in the surgery group underwent anterior CCT. Seizure control at 1-5 years after enrollment and changes of intelligence quotient (IQ) and quality of life (QOL) from pre-treatment to the 2-year follow-up were compared between the two groups.
  
  
  RESULTS
  The percentages of patients who were totally seizure-free in the surgery group were 17.4% at the 1-year follow-up, 13.0% at the 2-year follow-up and 8.7% at the 5-year follow up, and the data for patients in the medicine group were 2.9%, 5.9% and 2.9%, respectively. Significant differences were found in total seizure control between the two groups at 1, 2, and 5-year follow-up (personal χ2 test). Significant differences were found in mean changes of IQ and overall QOL between the medicine and surgery groups at the 2-year follow-up, showing positive results for the surgery group, but these changes were not related to postoperative outcomes of seizure control (t-test).
  
  
  CONCLUSIONS
  Anterior CCT is a promising treatment for school-aged children with LGS, and can present marked seizure control and improvement in QOL and IQ, all of which were significantly better than the effects of treatment with multiple AEDs.
authors.affiliation: Department of Neurosurgery, Capital Epilepsy Therapy Center, First Affiliated Hospital of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China. Electronic address: liangsl_304@sina.com.
authors.forename: Shuli
authors.initials: S
authors.lastname: Liang
authors.affiliation: Capital Epilepsy Therapy Center, First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Xiangping
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Psychology, First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Capital Epilepsy Therapy Center, First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiaoman
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007360:Intelligence; D065768:Lennox Gastaut Syndrome / Q000188:drug therapy / Q000601:surgery*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods*; D011446:Prospective Studies; D011788:Quality of Life; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants
keywords: Anterior corpus callosotomy; Anti-epilepsy drugs; Epileptic surgery; Lennox–Gastaut syndrome