title: The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis.
abstract: BACKGROUND
  The studies aimed to evaluate the changes in cysteine sulfur metabolism in erythrocytes of end-stage renal failure (ESRF) patients treated with continuous ambulatory peritoneal dialysis (CAPD) caused by a one-month lipoate (LA) supplementation at a daily dose of 600 mg.
  
  
  METHODS
  The level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of CAPD patients and in the control group.
  
  
  RESULTS
  The sulfane sulfur level in erythrocytes of CAPD patients did not differ compared with healthy volunteers but LA supplementation increased the reactive sulfur concentration. LA elevated also cystathionase activity.
  
  
  CONCLUSIONS
  LA supplementation in ESRF patients treated with CAPD increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties.
authors.affiliation: Jagiellonian University, Medical College, Kraków, Poland. Electronic address: miciek@cm-uj.krakow.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Iciek
authors.affiliation: Fressenius Nephrocare, Rydygier Hospital, Kraków, Poland.
authors.forename: Bernadeta
authors.initials: B
authors.lastname: Marcykiewicz
authors.affiliation: Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Bilska-Wilkosz
authors.affiliation: Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Sokołowska-Jeżewicz
authors.affiliation: Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kłapcińska
mesh_terms: D000328:Adult; D000368:Aged; D003545:Cysteine / Q000378:metabolism*; D019587:Dietary Supplements; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D008063:Thioctic Acid / Q000008:administration & dosage*
chemical_list: D008063:Thioctic Acid; D003545:Cysteine
keywords: Hydrogen sulfide; Lipoic acid; Peritoneal dialysis; Sulfane sulfur; Sulfurtransferases