title: Pomegranate juice and prostate cancer: importance of the characterisation of the active principle.
abstract: Two exploratory clinical studies investigating proprietary pomegranate products showed a trend of effectiveness in increasing prostate-specific antigen doubling time in patients with prostate cancer. A recent clinical study did not support these results. We therefore analysed a lot of the marketed pomegranate blend for co-active pomegranate compounds. The high-performance liquid chromatography method was used to detect punicalagin, ellagic acid and anthocyanins. Total polyphenoles were determined by the Folin-Ciocalteu method using gallic acid as reference. The results show that the co-active compounds in the daily dose of the pomegranate blend were far below those previously tested and that the photometric assessment is not reliable for the standardisation of study medications. Not pomegranate but the low amount of co-active compounds in the proprietary pomegranate blend was responsible for its clinical ineffectiveness.
authors.affiliation: Institute of Forensic Medicine, University of Freiburg, Albertstr. 9, 79104, Freiburg, Germany.
authors.forename: Sigrun
authors.initials: S
authors.lastname: Chrubasik-Hausmann
authors.forename: Christian
authors.initials: C
authors.lastname: Vlachojannis
authors.forename: Benno
authors.initials: B
authors.lastname: Zimmermann
mesh_terms: D000872:Anthocyanins / Q000032:analysis*; D001628:Beverages / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004610:Ellagic Acid / Q000032:analysis*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D047348:Hydrolyzable Tannins / Q000032:analysis*; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D059808:Polyphenols / Q000032:analysis*; D011471:Prostatic Neoplasms
chemical_list: D000872:Anthocyanins; D047348:Hydrolyzable Tannins; D059808:Polyphenols; D004610:Ellagic Acid; C115642:punicalagin
keywords: anthocyanins; ellagic acid; polyphenols; pomegranate; prostate cancer; punicalagin