title: Colloidal drug delivery system: amplify the ocular delivery.
abstract: BACKGROUND
  The ocular perceivers are the most voluntarily accessible organs in terms of location in the body, yet drug distribution to these tissues is one of the most intriguing and challenging endeavors and problematic to the pharmaceutical scientist. The most of ocular diseases are treated with topical application of conventional formulation, i.e. solutions, suspensions and ointment. Typically on installation of these conventional formulations, only <5% of the applied dose penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is wastage due to the presence of many ocular barriers like external barriers, rapid loss of the instilled solution from the precorneal area and nasolacrimal drainage system. Systemic absorption caused systemic side effects varying from mild to life-threatening events.
  
  
  OBJECTIVE
  The main objective of this review is to explore the role of colloidal delivery of drug to minimize the drawbacks associated with them.
  
  
  METHODS
  This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of colloidal delivery systems, i.e. nanoparticles, nanosuspensions, liposomes, niosomes, dendrimers and contact lenses containing nanoparticles have the capacity to distribute ocular drugs to categorical target sites and hold promise to revolutionize the therapy of many ocular perceiver diseases and minimized the circumscription of conventional delivery.
  
  
  CONCLUSIONS
  Form the basis of literature review, it has been found that the novel delivery system have greater impact to maximize ocular drug absorption, and minimize systemic absorption and side effects.
authors.affiliation: a Pharmaceutics PhD Lab, Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
authors.affiliation: a Pharmaceutics PhD Lab, Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Fazil
authors.affiliation: a Pharmaceutics PhD Lab, Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Qumbar
authors.affiliation: a Pharmaceutics PhD Lab, Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.
authors.forename: Nazia
authors.initials: N
authors.lastname: Khan
authors.affiliation: a Pharmaceutics PhD Lab, Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.
authors.forename: Asgar
authors.initials: A
authors.lastname: Ali
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003102:Colloids / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D003102:Colloids; D009883:Ophthalmic Solutions
keywords: Colloidal delivery system; eye; nanotechnology; ocular barriers; ocular transporter; pharmacokinetics