title: Influence of distal ileum exclusion on hepatic and renal functions in presence of extrahepatic cholestasis.
abstract: OBJECTIVE
  To verify whether the ileal exclusion interferes with liver and kidney functional changes secondary to extrahepatic cholestasis.
  
  
  METHODS
  We studied 24 rats, divided into three groups with eight individuals each: Group 1 (control), Group 2 (ligation of the hepatic duct combined with internal biliary drainage), and Group 3 (bile duct ligation combined with internal biliary drainage and exclusion of the terminal ileum). Animals in Group 1 (control) underwent sham laparotomy. The animals of groups 2 and 3 underwent ligation and section of the hepatic duct and were kept in cholestasis for four weeks. Next, they underwent an internal biliary bypass. In Group 3, besides the biliary-enteric bypass, we associated the exclusion of the last ten centimeters of the terminal ileum and carried out an ileocolic anastomosis. After four weeks of monitoring, blood was collected from all animals of the three groups for liver and kidney biochemical evaluation (albumin, ALT, AST, direct and indirect bilirubin, alkaline phosphatase, cGT, creatinine and urea).
  
  
  RESULTS
  there were increased values of ALT, AST, direct bilirubin, cGT, creatinine and urea in rats from Group 3 (p < 0.05).
  
  
  CONCLUSIONS
  ileal exclusion worsened liver and kidney functions in the murine model of extrahepatic cholestasis, being disadvantageous as therapeutic procedure for cholestatic disorders.
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Evandro Luis de Oliveira
authors.initials: EL
authors.lastname: Costa
authors.affiliation: Department of Surgery, Faculty of Medicine, UFMG.
authors.forename: Andy
authors.initials: A
authors.lastname: Petroianu
authors.affiliation: Betim Regional Hospital, Minas Gerais State Coroners Ofiice.
authors.forename: Geraldo Magela de
authors.initials: GM
authors.lastname: Azevedo Júnior
mesh_terms: D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000503:physiopathology*; D007082:Ileum / Q000601:surgery*; D007668:Kidney / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar