title: Regular menstrual cycles do not rule out ovarian damage in adult women with systemic lupus erythematosus.
abstract: The aim of this study was to evaluate ovarian reserve markers in women with systemic lupus erythematosus (SLE) and regular menstrual cycles, and explore the relationship of such markers with clinical and treatment features. This was a case-control study including 27 women with SLE and 27 controls. All participants were aged 18-40 years, were eumenorrheic and had not used hormone therapy or hormone contraceptives in the past six months. Clinical manifestations of SLE, past and current use of immunosuppressive therapy and organ damage index were assessed at a regular follow-up visit, while antral follicle count (AFC), serum anti-Mullerian hormone (AMH) and follicle-stimulating hormone (FSH) were assessed at early follicular phase of menstrual cycle. AFC was significantly reduced in SLE women [median (interquartile interval) 7 (5-11) versus 11 (7-12), p = 0.029]. AMH levels were more heterogeneous in SLE patients compared to the control group [1.23 (0.24-4.63) ng/ml versus 1.52 (1.33-1.88) ng/ml]. The SLE and control groups had similar serum FSH levels [6.44 (4.19-7.69) versus 7.5 (6.03-8.09) IU/L, p = 0.135]. AFC was inversely correlated with organ damage index (p = 0.046) and cumulative dose of cyclophosphamide (p = 0.028), while AMH levels were negatively correlated with the maximal dose of corticosteroid ever used (p = 0.003). These findings suggest that ovarian reserve may be decreased in women with SLE despite regular menstrual cycles.
authors.affiliation: Department of Obstetrics and Gynecology and.
authors.forename: Olivio B
authors.initials: OB
authors.lastname: Malheiro
authors.forename: Carolina P
authors.initials: CP
authors.lastname: Rezende
authors.forename: Ana Luiza L
authors.initials: AL
authors.lastname: Rocha
authors.forename: Helen L
authors.initials: HL
authors.lastname: Del Puerto
authors.forename: Gilda A
authors.initials: GA
authors.lastname: Ferreira
authors.forename: Fernando M
authors.initials: FM
authors.lastname: Reis
mesh_terms: D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000503:physiopathology*; D008597:Menstrual Cycle / Q000097:blood / Q000502:physiology*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D065851:Ovarian Reserve / Q000502:physiology*; D014463:Ultrasonography
chemical_list: D015415:Biomarkers
keywords: Anti-Mullerian hormone; antral follicle count; follicle-stimulating hormone; ovarian reserve; systemic lupus erythematosus