title: Thermoresponsive magnetic nanoparticle--aminated guar gum hydrogel system for sustained release of doxorubicin hydrochloride.
abstract: Hydrogel based sustained drug delivery system has evolved as an immense treatment method for solid tumors over the past few decades with long term theranostic ability. Here, we synthesized an injectable hydrogel system comprising biocompatible aminated guar gum, Fe3O4-ZnS core-shell nanoparticles and doxorubicin hydrochloride. We show that amination of guar gum resulted in attraction of water molecules thereby forming the hydrogel without using toxic crosslinking agents. Hydrogel formation was observed at 37°C and is stable up to 95°C. The prepared hydrogel is also stable over a wide pH range. The in vitro studies show that the maximum de-gelation and drug release up to 90% can be achieved after 20 days of incubation. Studies reveal that the drug and the core-shell nanoparticles can be released slowly from the hydrogel to provide the healing and diagnosis of the solid tumor thereby avoiding several drug administrations and total excision of organs.
authors.affiliation: Advanced Materials Laboratory, Centre for Leather Apparel & Accessories Development, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600020, India.
authors.forename: Ragothaman
authors.initials: R
authors.lastname: Murali
authors.affiliation: Advanced Materials Laboratory, Centre for Leather Apparel & Accessories Development, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600020, India.
authors.forename: Ponraj
authors.initials: P
authors.lastname: Vidhya
authors.affiliation: Advanced Materials Laboratory, Centre for Leather Apparel & Accessories Development, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600020, India. Electronic address: thanik8@yahoo.com.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Thanikaivelan
mesh_terms: D000586:Amination; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D005685:Galactans / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D013696:Temperature
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D005685:Galactans; D058185:Magnetite Nanoparticles; D008351:Mannans; D053149:Plant Gums; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D004317:Doxorubicin; C007894:guar gum
keywords: Aminated guar gum; Biomedical imaging; Core–shell nanoparticles; Doxorubicin HCl; Solid tumor