title: A tour through the transcriptional landscape of platelets.
abstract: The RNA code found within a platelet and alterations of that code continue to shed light onto the mechanistic underpinnings of platelet function and dysfunction. It is now known that features of messenger RNA (mRNA) in platelets mirror those of nucleated cells. This review serves as a tour guide for readers interested in developing a greater understanding of platelet mRNA. The tour provides an in-depth and interactive examination of platelet mRNA, especially in the context of next-generation RNA sequencing. At the end of the expedition, the reader will have a better grasp of the topography of platelet mRNA and how it impacts platelet function in health and disease.
authors.affiliation: The Molecular Medicine Program and.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schubert
authors.affiliation: The Molecular Medicine Program and Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Weyrich
authors.affiliation: The Molecular Medicine Program and Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.
authors.forename: Jesse W
authors.initials: JW
authors.lastname: Rowley
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D015539:Platelet Activation / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger