title: Synthesis and degradation of poly(ADP-ribose) in plants.
abstract: Poly(ADP-ribosylation) is a post-translational modification of proteins involved in a wide range of molecular and cellular processes in mammalian system. The main enzymes responsible for this modification are the poly(ADP-ribose) polymerases that catalyze the transfer of ADP-ribose moieties from NAD + to target protein acceptors, producing long and branched ADP-ribose polymers. The poly(ADP-ribosyl)ation is rapidly reverted by poly(ADP-ribose) glycohydrolase enzymes, which hydrolyzes poly(ADP-ribose) polymers, generating free ADP-ribose. So far, nine proteins with a poly(ADP-ribose) polymerase signature and two poly(ADP-ribose) glycohydrolase enzymes encoded by two adiacent genes were identified in Arabidopsis . The present review will describe the structures and functions of plant poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolases.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bianchi
authors.forename: Anna
authors.initials: A
authors.lastname: De Maio
mesh_terms: D000040:Abscisic Acid / Q000494:pharmacology; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000187:drug effects / Q000528:radiation effects; D010937:Plant Growth Regulators / Q000494:pharmacology; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D011839:Radiation, Ionizing; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D010937:Plant Growth Regulators; D017382:Reactive Oxygen Species; D011064:Poly Adenosine Diphosphate Ribose; D000040:Abscisic Acid; D011065:Poly(ADP-ribose) Polymerases