title: Involvement of PARPs in cell death.
abstract: Poly(ADP-ribosylation), an NAD dependent reaction culminating in the formation of ADP-ribose monomers, and their following polymerization, is activated as an emergency process in crucial situations such as DNA damage and cellular stress; due to this crucial function, the modulation of poly(ADP-ribosylation) during cell death has been investigated. This review will describe the properties of poly(ADP-ribose) as a signalling molecule in different paradigms of cell death, i.e.apoptosis, parthanatos, necroptosis and autophagy.
authors.affiliation: Istituto di Genetica Molecolare CNR, Pavia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Aredia
authors.affiliation: Istituto di Genetica Molecolare CNR, Pavia, Italy.
authors.forename: Anna Ivana
authors.initials: AI
authors.lastname: Scovassi
mesh_terms: D016923:Cell Death / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011064:Poly Adenosine Diphosphate Ribose