title: Identification of aminopyridazine-derived antineuroinflammatory agents effective in an Alzheimer's mouse model.
abstract: Targeting neuroinflammation may be a new strategy to combat Alzheimer's disease. An aminopyridazine 1b previously reported as a novel antineuroinflammatory agent was considered to have a potential therapeutic effect for Alzheimer's disease. In this study, we further explored the chemical space to identify more potent antineuroinflammatory agents and validate their in vivo efficacy in an animal model. Compound 14 was finally identified as an effective agent with comparable in vivo efficacy to the marketed drug donepezil in counteracting spatial learning and working memory impairment in an Aβ-induced Alzheimer's mouse model.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.
authors.forename: Guifa
authors.initials: G
authors.lastname: Zhong
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.
authors.forename: Xiurong
authors.initials: X
authors.lastname: Rao
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.
authors.forename: Shaogao
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
authors.forename: Tianyan
authors.initials: T
authors.lastname: Chi
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
authors.forename: Libo
authors.initials: L
authors.lastname: Zou
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.
authors.forename: Donghai
authors.initials: D
authors.lastname: Wu
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China ; State Key Laboratory of Respiratory Disease , Guangzhou 510120, People's Republic of China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Hu
keywords: Alzheimer's disease; Morris water maze; animal model; antineuroinflammatory agent; neuroinflammation