title: Malignant rhabdoid tumor of the liver presented with initial tumor rupture.
abstract: Malignant rhabdoid tumor (MRT) of the liver is a rare, highly aggressive tumor of early childhood. We report a 6-month-old boy who was diagnosed with MRT of the liver and presented with spontaneous tumor rupture. The patient underwent intensified chemotherapy and a radical surgical procedure. Twenty four months from the time of the diagnosis, he is alive without evidence of disease. This is the second report of prolonged survival after initial rupture of hepatic MRT.
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation. Electronic address: kachanov78@gmail.com.
authors.forename: Denis
authors.initials: D
authors.lastname: Kachanov
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Margarita
authors.initials: M
authors.lastname: Teleshova
authors.affiliation: Department of Liver Transplantation, acad. B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation.
authors.forename: Eduard
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Dobrenkov
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Roman
authors.initials: R
authors.lastname: Moiseenko
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Anastasya
authors.initials: A
authors.lastname: Usychkina
authors.affiliation: Department of Liver Transplantation, acad. B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation.
authors.forename: Andrey
authors.initials: A
authors.lastname: Filin
authors.affiliation: Department of Liver Transplantation, acad. B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation.
authors.forename: Alexey
authors.initials: A
authors.lastname: Semenkov
authors.affiliation: Department of Pathology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Anna
authors.initials: A
authors.lastname: Mitrofanova
authors.affiliation: Department of Pathology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Konovalov
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Shamanskaya
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Galina
authors.initials: G
authors.lastname: Novichkova
authors.affiliation: Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Varfolomeeva
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D008297:Male; D018335:Rhabdoid Tumor / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D012421:Rupture; D000071796:SMARCB1 Protein; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors
keywords: Malignant rhabdoid tumor; chemotherapy; liver; tumor rupture