title: Atypical Spitzoid neoplasms: a review of potential markers of biological behavior including sentinel node biopsy.
abstract: Atypical cutaneous melanocytic lesions, including those with Spitzoid features, can be difficult to categorize as benign or malignant. This can lead to suboptimal management, with potential adverse patient outcomes. Recent studies have enhanced knowledge of the molecular and genetic biology of these lesions and, combined with clinicopathological findings, is further defining their biological spectrum, classification, and behavior. Sentinel node biopsy provides important prognostic information in patients with cutaneous melanoma, but its role in the management of melanocytic lesions of uncertain malignant potential (MELTUMP) is controversial. This paper examines the role of molecular testing and sentinel node biopsy in MELTUMPs, particularly atypical Spitzoid tumors.
authors.affiliation: aPeter Macallum Cancer Institute, East Melbourne bVictorian Melanoma Service, Alfred Hospital, Prahran cDepartment of Paediatrics, Murdoch Children's Research Institute, Royal Children's Hospital, The University of Melbourne, Parkville dThe Royal Children's Hospital, Flemington Road, Parkville, Victoria eMelanoma Institute Australia , Royal Prince Alfred Hospital, The University of Sydney, Sydney, New South Wales, Australia fDepartment of Medicine, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McCormack
authors.forename: Rachel K
authors.initials: RK
authors.lastname: Conyers
authors.forename: Richard A
authors.initials: RA
authors.lastname: Scolyer
authors.forename: John
authors.initials: J
authors.lastname: Kirkwood
authors.forename: David
authors.initials: D
authors.lastname: Speakman
authors.forename: Nick
authors.initials: N
authors.lastname: Wong
authors.forename: John W
authors.initials: JW
authors.lastname: Kelly
authors.forename: Michael A
authors.initials: MA
authors.lastname: Henderson
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology*; D011230:Precancerous Conditions / Q000175:diagnosis*; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*; D000096142:Cutaneous Malignant Melanoma
chemical_list: D014408:Biomarkers, Tumor