title: Potent protein glycation inhibition of plantagoside in Plantago major seeds.
abstract: Plantagoside (5,7,4',5'-tetrahydroxyflavanone-3'-O-glucoside) and its aglycone (5,7,3',4',5'-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation. These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications.
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.affiliation: University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Aradate
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Kosugi-machi, Imizu-gun, Toyama 939-0398, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kurosaka
authors.affiliation: Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Kittaka
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nakaminami
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan ; Department of Pharmaceutical Science, Graduate School of Medicine, Density and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Gamo
authors.affiliation: Ichimaru Pharcos Co., Ltd., 318-1 Asagi, Motosu-shi, Gifu 501-0475, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kojima
authors.affiliation: Ichimaru Pharcos Co., Ltd., 318-1 Asagi, Motosu-shi, Gifu 501-0475, Japan.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ohara
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000378:metabolism; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D010943:Plantago / Q000737:chemistry*; D011506:Proteins / Q000378:metabolism*; D012639:Seeds / Q000737:chemistry*; D013379:Substrate Specificity / Q000187:drug effects
chemical_list: D000596:Amino Acids; D003432:Cross-Linking Reagents; D044950:Flavanones; D005960:Glucosides; D017127:Glycation End Products, Advanced; D011506:Proteins; C062295:plantagoside