title: [Antiretroviral therapy in HIV-infected children and adolescents: lessons learned in 30 years of the epidemic].
abstract: This study aims to evaluate antiretroviral therapy in children and adolescents with AIDS. We selected 247 abstracts published from 1983 to 2013, collected from the PubMed and LILACS databases. Sixty-nine articles were selected. Attention to research in the pediatric age bracket in 30 years of the epidemic is explained by the age group's immunological characteristics, since AIDS progresses faster in children than in adults. Recent studies focus on the initiation of highly active antiretroviral therapy before the onset of symptoms. Early introduction of combination antiretroviral therapy has been implemented effectively and safely in populations with limited resources, leading to significantly improved survival. The current challenge is to manage a chronic disease with acute complications. New studies should focus on population specificities and identify the individual needs of pediatric patients.
authors.forename: Gabriela Ricordi
authors.initials: GR
authors.lastname: Bazin
authors.forename: Mariza Curto Saavedra
authors.initials: MC
authors.lastname: Gaspar
authors.forename: Nicole Carvalho Xavier Micheloni da
authors.initials: NC
authors.lastname: Silva
authors.forename: Carolina da Costa
authors.initials: Cda C
authors.lastname: Mendes
authors.forename: Cora Pichler de
authors.initials: CP
authors.lastname: Oliveira
authors.forename: Leonardo Soares
authors.initials: LS
authors.lastname: Bastos
authors.forename: Claudete Aparecida Araújo
authors.initials: CA
authors.lastname: Cardoso
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D001938:Brazil / Q000453:epidemiology; D002648:Child; D058872:Epidemics; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008297:Male; D016019:Survival Analysis
chemical_list: D019380:Anti-HIV Agents