title: Effect of inhaled magnesium sulfate on bronchial hyperresponsiveness.
abstract: OBJECTIVE
  To determine the response of nebulized magnesium sulfate on the lung function of children with bronchial hyperresponsiveness.
  
  
  METHODS
  Eighty-four children with asthma were divided into three groups randomly: magnesium sulfate (M), albuterol (A), and a combination of magnesium sulfate and albuterol (M + A). All patients were nebulized with acetylcholine, and then treated as designed. Lung function was compared between the three groups.
  
  
  RESULTS
  Forced expiratory volume in first second (FEV1) significantly improved in all the three groups but it was better in (A) and (M + A) compared to (M) at 10 min and 20 min [10 min: 1.26 L ± 0.53 (A) vs. 1.10 L ± 0.27 (M), 1.35 L ± 0.59 (M + A) vs. 1.10 L ± 0.27 (M), p < 0.05; 20 min: 1.32 L ± 0.61 (A) vs. 1.17 L ± 0.30 (M), 1.42 L ± 0.59 (M + A) vs. 1.17 L ± 0.30 (M), p < 0.05]. Variation of FEV1, as absolute value at 10 min or 20 min over post-Ach FEV1 was significantly different in (A) or (M + A) compared to (M).
  
  
  CONCLUSIONS
  Nebulized albuterol and magnesium sulfate + albuterol can more effectively improve FEV1 in children with bronchial hyperresponsiveness than nebulized magnesium sulfate at 10 min and 20 min after inhalation. It is further suggested that addition of magnesium sulfate to albuterol does not result in additional benefit.
authors.affiliation: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiong
authors.forename: Caihui
authors.initials: C
authors.lastname: Gong
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yuan
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.forename: Tiantian
authors.initials: T
authors.lastname: Shi
authors.forename: Jihong
authors.initials: J
authors.lastname: Dai
mesh_terms: D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D009330:Nebulizers and Vaporizers; D012129:Respiratory Function Tests / Q000379:methods; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D008278:Magnesium Sulfate; D000420:Albuterol