title: Phagosomal TLR signaling upon Borrelia burgdorferi infection.
abstract: Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.
authors.affiliation: Department of Pediatrics, University of Connecticut Health Center Farmington, CT, USA ; Division of Infectious Diseases, Connecticut Children's Medical Center Hartford, CT, USA.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Cervantes
authors.affiliation: Department of Pediatrics, University of Connecticut Health Center Farmington, CT, USA ; Division of Infectious Diseases, Connecticut Children's Medical Center Hartford, CT, USA.
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Hawley
authors.affiliation: Department of Pediatrics, University of Connecticut Health Center Farmington, CT, USA.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Benjamin
authors.affiliation: Department of Pediatrics, University of Connecticut Health Center Farmington, CT, USA.
authors.forename: Bennett
authors.initials: B
authors.lastname: Weinerman
authors.affiliation: Department of Molecular Biology and Biophysics, University of Connecticut Health Center Farmington, CT, USA.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Luu
authors.affiliation: Department of Pediatrics, University of Connecticut Health Center Farmington, CT, USA ; Division of Infectious Diseases, Connecticut Children's Medical Center Hartford, CT, USA ; Department of Immunology, University of Connecticut Health Center Farmington, CT, USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Salazar
mesh_terms: D000818:Animals; D025065:Borrelia burgdorferi / Q000276:immunology*; D006801:Humans; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology; D010586:Phagocytes / Q000276:immunology / Q000382:microbiology; D010588:Phagosomes / Q000276:immunology* / Q000382:microbiology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
chemical_list: D051193:Toll-Like Receptors
keywords: Borrelia burgdorferi; Lyme disease; innate immunity; phagosomal signaling; toll-like receptors