title: Electrophilic trifluoromethylthiolation of carbonyl compounds.
abstract: A general method for the α-trifluoromethylthiolation of carbonyl compounds, without prefunctionalization, has been developed. Aldehydes, ketones, esters, amides, keto-esters, alkaloids, and steroids have been trifluoromethylthiolated with good yields. This work, proposing a new reagent for electrophilic trifluoromethylthiolation, provides a route towards the original synthesis of various trifluoromethylthiolated molecules for further applications.
authors.affiliation: Institute of Chemistry and Biochemistry (ICBMS - UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918-69622 Lyon (France); CERMEP - in vivo imaging Groupement Hospitalier Est, 59 Bd Pinel - 69003 Lyon (France).
authors.forename: Sébastien
authors.initials: S
authors.lastname: Alazet
authors.forename: Luc
authors.initials: L
authors.lastname: Zimmer
authors.forename: Thierry
authors.initials: T
authors.lastname: Billard
keywords: carbonyl compounds; enols; fluorine; trifluoromethanesulfenamide; trifluoromethylthiolation