title: Expression patterns of stromal MMP-2 and tumoural MMP-2 and -9 are significant prognostic factors in invasive ductal carcinoma of the breast.
abstract: Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types of solid tumours. In particular, stromal MMP-2 plays important roles in the progression of malignant tumours, but most clinical studies have focused on tumoural MMP-2 and -9 expression, and not stromal MMP-2 expression. One hundred and seventy-seven cases diagnosed as invasive ductal carcinoma of the breast between 2000 and 2005 were included in this study. Expressions of tumoural MMP-2 and -9 and stromal MMP-2 were analysed by immunostaining on a tissue microarray. Subsequently, the associations between those results and various clinicopathological parameters were evaluated. Stromal MMP-2 expression correlated significantly with clinicopathological parameters such as advanced T category, larger tumour size, high histological grade, tumour necrosis, ER- and PR-negative, and HER-2-positive (all p < 0.05). In univariate and multivariate analyses, overall survival was linked with stromal MMP-2 expression as well as dual expression of stromal MMP-2 and tumoural MMP-2 and -9 (all p < 0.05). Stromal MMP-2 expression may play a crucial role in predicting aggressive clinical behaviour in breast cancer patients.
authors.affiliation: Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Kyueng-Whan
authors.initials: KW
authors.lastname: Min
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Sung-Im
authors.initials: SI
authors.lastname: Do
authors.forename: Kyungeun
authors.initials: K
authors.lastname: Kim
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Seoung Wan
authors.initials: SW
authors.lastname: Chae
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Sohn
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Pyo
authors.forename: Young-Ha
authors.initials: YH
authors.lastname: Oh
authors.forename: Wan-Seop
authors.initials: WS
authors.lastname: Kim
authors.forename: So-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Sukjoong
authors.initials: S
authors.lastname: Oh
authors.forename: Seon Hyeong
authors.initials: SH
authors.lastname: Choi
authors.forename: Yong Lai
authors.initials: YL
authors.lastname: Park
authors.forename: Chan Heun
authors.initials: CH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D018719:Erb-b2 Receptor Tyrosine Kinases; C522361:MMP2 protein, human; C579270:MMP9 protein, human
keywords: MMP2; MMP9; breast; invasive ductal carcinoma; stromal cell