title: Depression and its measurement in verbal adolescents and adults with autism spectrum disorder.
abstract: In a sample of 50 verbally fluent adolescents and adults with autism spectrum disorders (age: 16-31 years; verbal IQ: 72-140), we examined the pattern of response and associations between scores on common measures of depressive symptoms, participant characteristics, and clinical diagnosis of depressive disorders. Beck Depression Inventory-Second Edition item descriptives in this autism spectrum disorder sample were compared to previously published data from a large typically developing sample, with results suggesting that cognitive-attributional symptoms of depression may be particularly prevalent in autism spectrum disorder. Scores on a variety of self- and parent-report depression measures were not associated with chronological age or verbal IQ, and were relatively highly correlated with each other and with clinical diagnosis of a mood disorder. The Beck Depression Inventory-Second Edition and the Adult Self-Report "Depressive" scale best identified both depressed and non-depressed participants in this sample, though neither was particularly strong. Validation studies of depression measures in the autism spectrum disorder population are necessary to advance research into this prevalent and impairing comorbidity.
authors.affiliation: Vanderbilt University Medical Center, USA katherine.gotham@vanderbilt.edu.
authors.forename: Katherine
authors.initials: K
authors.lastname: Gotham
authors.affiliation: Vanderbilt University, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Unruh
authors.affiliation: Weill Cornell Medical College, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
mesh_terms: D000293:Adolescent; D000328:Adult; D000067877:Autism Spectrum Disorder / Q000523:psychology*; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D007360:Intelligence; D007804:Language Development; D008297:Male; D057566:Self Report; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Adult Behavior Checklist; Adult Self-Report; Beck Depression Inventory; autism spectrum disorder; depression; self-report