title: Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: possible morphological and biochemical alterations.
abstract: BACKGROUND
  Inflammatory bowel disease (IBD) is characterized by most common symptoms such as rectal bleeding. Lack of specific, curative treatments tempted us to evaluate the therapeutic efficacy of quercetin against acetic acid induced IBD like symptoms.
  
  
  METHODS
  Animals were randomly divided into five groups (n = 6): naive, control, sulphasalazine and quercetin, and were pretreated for three days. Colitis was induced by intra-rectal administration of 3% acetic acid.
  
  
  RESULTS
  Pretreatment with sulphasalazine or quercetin significantly attenuated the biochemical and morphological alterations in the colon induced by acetic acid in rats.
  
  
  CONCLUSIONS
  The findings of the study suggest the possible role of quercetin as therapeutics in IBD.
authors.affiliation: University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India; Department of Pharmacology, Vaagdevi College of Pharmacy, Warangal, India. Electronic address: dilipd4u@gmail.com.
authors.forename: Dilip
authors.initials: D
authors.lastname: Dodda
authors.affiliation: Department of Pharmacology, NMT Gujarati College of Pharmacy, Indore, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Chhajed
authors.affiliation: Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Ganjam, Odisha, India; University Institute of Pharmaceutical Sciences, UGC Center of Advanced Studies, Panjab University, Chandigarh, India.
authors.forename: Jitendriya
authors.initials: J
authors.lastname: Mishra
mesh_terms: D019342:Acetic Acid; D000818:Animals; D003106:Colon / Q000473:pathology; D005978:Glutathione / Q000032:analysis; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009573:Nitrites / Q000097:blood; D009195:Peroxidase / Q000378:metabolism; D011794:Quercetin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009573:Nitrites; D011794:Quercetin; D009195:Peroxidase; D005978:Glutathione; D019342:Acetic Acid
keywords: Acetic acid; Inflammatory bowel disease; Myeloperoxidase; Quercetin; Ulcer area