title: Cyclodextrin-benzoic acid binding in salt solutions: effects of biologically relevant anions.
abstract: Inclusion complex formation of benzoic acid with α-, β- and γ-cyclodextrins in water and in 0.2 M solutions of inorganic salts (KCl, KBr, KH2PO4 and K2SO4) has been studied by means of 1H NMR at 298.15 K. Binding constants have been determined and role of biologically active inorganic anions in the inclusion complex formation has been revealed. It has been shown that effects of the anions are determined not only by changing the ionic strength. More pronounced influence of Br- and H2PO4- compared with Cl- and SO4(2-) is caused by specific ion-molecular interactions, occurrence of which depends on the physical-chemical properties of the anions as well as on the binding mode of cyclodextrins with benzoic acid. Competing interactions of cyclodextrin-anion were observed in the presence of KBr, while the ternary complex formation was detected upon addition of KH2PO4.
authors.affiliation: G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation. Electronic address: ivt@isc-ras.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Terekhova
authors.affiliation: G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.
authors.forename: E S
authors.initials: ES
authors.lastname: Chibunova
authors.affiliation: G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.
authors.forename: R S
authors.initials: RS
authors.lastname: Kumeev
authors.affiliation: G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.
authors.forename: G A
authors.initials: GA
authors.lastname: Alper
mesh_terms: D000838:Anions / Q000737:chemistry; D019817:Benzoic Acid / Q000737:chemistry*; D001665:Binding Sites; D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012492:Salts / Q000737:chemistry*; D012996:Solutions
chemical_list: D000838:Anions; D003505:Cyclodextrins; D012492:Salts; D012996:Solutions; D019817:Benzoic Acid
keywords: Complex formation; Cyclodextrin; Salt effects