title: Potentials of polymeric nanoparticle as drug carrier for cancer therapy: with a special reference to pharmacokinetic parameters.
abstract: Nanomaterials have made a significant impact on cancer therapeutics and an emergence of polymeric nanoparticle provides a unique platform for delivery of drug molecules of diverse nature. Nanoparticles can be targeted at the tumor cells due to enhanced permeability and retention effect. Moreover, nanoparticles can be grafted by various ligands on their surface to target the specific receptors overexpressed by cancer cells or angiogenic endothelial cells. These approaches ultimately result in longer circulation half-lives, improved drug pharmacokinetics, reduced side effects of therapeutically active substances and overcoming cancer chemo-resistance thereby enhancing the therapeutic efficacy of the treatment. This review article summarizes the recent efforts in cancer nanochemotherapeutics using polymeric nanoparticles with a special reference to their pharmacokinetic and biodistribution profiles, their role in reversing multidrug resistance in cancer and strategies of tumor targeting with them, along with the challenges in the field.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Mukherjee
authors.forename: Surajit
authors.initials: S
authors.lastname: Das
authors.forename: Samrat
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Bhabani Sankar
authors.initials: BS
authors.lastname: Satapathy
authors.forename: Pranab Jyoti
authors.initials: PJ
authors.lastname: Das
authors.forename: Laboni
authors.initials: L
authors.lastname: Mondal
authors.forename: Chowdhury Mobaswar
authors.initials: CM
authors.lastname: Hossain
authors.forename: Niladri Shekhar
authors.initials: NS
authors.lastname: Dey
authors.affiliation: Research & Development, Procter & Gamble, 70 Biopolis Street, Singapore138547, Republic of Singapore. urajitdas1982@yahoo.com.
authors.forename: Anumita
authors.initials: A
authors.lastname: Chaudhury
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D018432:Drug Resistance, Multiple / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D011108:Polymers