title: [Genetic diagnosis for epilepsy].
abstract: Very few epilepsy phenotypes have been associated with causative genes; nevertheless, it is becoming possible, for some epilepsy phenotypes, to predict the most efficacious anti-epileptic drugs for patients based on their genetic makeup. The development of individualized medicine based on genetic information and the genetic diagnosis of epilepsy are expected to greatly improve the diagnosis and treatment of epilepsy. We developed DNA array(resequencing-array) for genetic diagnosis of epilepsy, and successfully identified epilepsy mutations in patients. This finding indicates that this DNA array is likely to be a useful tool in clinical settings at least for screening purposes, because it can simultaneously and efficiently detect several gene mutations in a patient.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sugawara
authors.forename: Sunao
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009154:Mutation
chemical_list: D007473:Ion Channels