title: Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation.
abstract: Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA patients and healthy individuals. Eleven patients with SCA and 15 healthy subjects completed a 20-min duration submaximal cycling exercise at ≈45 Watts. Plasma markers of oxidative stress, antioxidant activity, endothelial activation and nitric oxide bioavailability were investigated before and after the exercise. Nitric oxide levels, anti-oxidant capacity, soluble (s)E-selectin and sP-selectin did not change in response to this exercise. Except for the malondialdehyde levels, which increased in the two groups, the other markers of oxidative stress remained unchanged in both groups in response to exercise. Soluble vascular cell adhesion molecule 1 levels were increased at the end of exercise in both groups. sL-selectin decreased and soluble intercellular adhesion molecule 1 increased with exercise in SCA patients only. The present data suggest that patients with SCA may undertake mild-moderate physical activities without any acute clinical complications, but care should be taken because oxidative stress and endothelial activation significantly increased in some patients.
authors.affiliation: CRIS EA647, Université de Lyon 1, Villeurbanne, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Faes
authors.forename: Edwige
authors.initials: E
authors.lastname: Balayssac-Siransy
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
authors.forename: Ludovic
authors.initials: L
authors.lastname: Hivert
authors.forename: Clotaire
authors.initials: C
authors.lastname: Danho
authors.forename: Pascal
authors.initials: P
authors.lastname: Bogui
authors.forename: Cyril
authors.initials: C
authors.lastname: Martin
authors.forename: Vincent
authors.initials: V
authors.lastname: Pialoux
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D016022:Case-Control Studies; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D055815:Young Adult
chemical_list: D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide
keywords: lipid peroxidation; sickle cell disease; submaximal exercise; vascular adhesion molecules