title: Orbital Involvement by NUT Midline Carcinoma.
abstract: A 32-year-old female presented with a sino-orbital lesion that proved to be a NUT midline carcinoma. This is only the third case of orbital involvement by this aggressive lesion. The clinical, radiographic, and histopathologic features of NUT midline carcinoma are discussed, as well as its management options.
authors.affiliation: *Department of Otolaryngology/Head Neck Surgery, Thomas Jefferson University Hospital, Philadelphia; †Department of Ophthalmology, Geisinger Health System, Danville; ‡The Commonwealth Medical College, Scranton; §Department of Pathology; ‖Department of Neurosurgery, Thomas Jefferson University Hospital; and ¶Skull Base Division, Neuro-Ophthalmology Service, Wills Eye Hospital, Philadelphia, Pennsylvania, U.S.A.
authors.forename: Jill N
authors.initials: JN
authors.lastname: D'Souza
authors.forename: Gregory
authors.initials: G
authors.lastname: Notz
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Bogdasarian
authors.forename: David M
authors.initials: DM
authors.lastname: Cognetti
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Curry
authors.forename: Marc R
authors.initials: MR
authors.lastname: Rosen
authors.forename: Madalina
authors.initials: M
authors.lastname: Tuluc
authors.forename: James J
authors.initials: JJ
authors.lastname: Evans
authors.forename: Jurij R
authors.initials: JR
authors.lastname: Bilyk
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D018797:Cell Cycle Proteins; D059248:Chemoradiotherapy; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D009363:Neoplasm Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D049268:Positron-Emission Tomography; D011247:Pregnancy; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics; D000092468:Bromodomain Containing Proteins
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D014157:Transcription Factors; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C000630260:NUTM1 protein, human