title: Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass.
abstract: A multifunctional magnetic mesoporous bioactive glass (MMBG) has been widely used for a drug delivery system, but its biological properties have been rarely reported. Herein, the effects of mesopores and Fe3O4 nanoparticles on drug loading-release property, bactericidal property and biocompatibility have been investigated by using mesoporous bioactive glass (MBG) and non-mesoporous bioactive glass (NBG) as control samples. Both MMBG and MBG have better drug loading efficiency than NBG because they possess ordered mesoporous channels, big specific surface areas and high pore volumes. As compared with MBG, the Fe3O4 nanoparticles in MMBG not only provide magnetic property, but also improve sustained drug release property. For gentamicin-loaded MMBG (Gent-MMBG), the sustained release of gentamicin and the Fe3O4 nanoparticles minimize bacterial adhesion significantly and prevent biofilm formation against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Moreover, the magnetic Fe3O4 nanoparticles in MMBG can promote crucial cell functions such as cell adhesion, spreading and proliferation. The excellent biocompatibility and drug delivery property of MMBG suggest that Gent-MMBG has great potentials for treatment of implant-associated infections.
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Liu
authors.affiliation: Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Xi-Bin
authors.initials: XB
authors.lastname: Yu
authors.affiliation: Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Liu
authors.affiliation: Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China. Electronic address: zhuzhenan2006@126.com.
authors.forename: Zhen-An
authors.initials: ZA
authors.lastname: Zhu
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China. Electronic address: ypguo@shnu.edu.cn.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Guo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005839:Gentamicins / Q000737:chemistry / Q000494:pharmacology; D005898:Glass / Q000737:chemistry*; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D016062:Porosity; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D005839:Gentamicins; D058185:Magnetite Nanoparticles; D052203:Ferrosoferric Oxide
keywords: Bactericidal property; Biocompatibility; Drug delivery system; Magnetic property; Mesoporous bioactive glass