title: Anti-diabetic effect of dietary mango (Mangifera indica L.) peel in streptozotocin-induced diabetic rats.
abstract: BACKGROUND
  In the present study, the composition of mango peel powder (MPP) collected from the mango pulp industry was determined and the effect of MPP on ameliorating diabetes and its associated complications was studied.
  
  
  RESULTS
  Mango peel was rich in polyphenols, carotenoids and dietary fibre. Peel extract contained various bioactive compounds and was found to be rich in soluble dietary fibre. Peel extract exhibited antioxidant properties and protected against DNA damage. Therefore, the effect of peel on ameliorating diabetes was investigated in a rat model of diabetes. A significant increase in urine sugar, urine volume, fasting blood glucose, total cholesterol, triglycerides and low density lipoprotein, and decrease in high density lipoprotein were observed in the rats; however, these parameters were ameliorated in diabetic rats fed with diet supplemented with mango peel at 5% and 10% levels in basal diet. Treatment of diabetic rats with MPP increased antioxidant enzyme activities and decreased lipid peroxidation in plasma, kidney and liver compared to untreated diabetic rats. Glomerular filtration rate and microalbuminuria levels were ameliorated in MPP treated diabetic group.
  
  
  CONCLUSIONS
  Mango peel, a by-product, can be used as an ingredient in functional and therapeutic foods.
authors.affiliation: Department of Biochemistry and Nutrition, CSIR - Central Food Technological Research Institute, Mysore, - 570020, India.
authors.forename: Mahendranath
authors.initials: M
authors.lastname: Gondi
authors.forename: Shaik Akbar
authors.initials: SA
authors.lastname: Basha
authors.forename: Jamuna J
authors.initials: JJ
authors.lastname: Bhaskar
authors.forename: Paramahans V
authors.initials: PV
authors.lastname: Salimath
authors.forename: Ummiti J S Prasada
authors.initials: UJ
authors.lastname: Rao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000517:prevention & control; D019587:Dietary Supplements / Q000191:economics; D005525:Food-Processing Industry / Q000191:economics; D005638:Fruit / Q000737:chemistry*; D006943:Hyperglycemia / Q000517:prevention & control; D006949:Hyperlipidemias / Q000150:complications / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D007194:India; D007220:Industrial Waste / Q000032:analysis / Q000191:economics; D007668:Kidney / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D031022:Mangifera / Q000737:chemistry*; D050177:Overweight / Q000150:complications / Q000517:prevention & control; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000097:blood / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D007004:Hypoglycemic Agents; D007220:Industrial Waste; D010936:Plant Extracts; D010088:Oxidoreductases
keywords: antioxidant enzymes; diabetes; mango peel; oxidative stress; streptozotocin induced diabetes