title: Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.
abstract: This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Chris P
authors.initials: CP
authors.lastname: Miller
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Maysoun
authors.initials: M
authors.lastname: Shomali
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: C Richard
authors.initials: CR
authors.lastname: Lyttle
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Louis St L
authors.initials: LS
authors.lastname: O'Dea
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Hillary
authors.initials: H
authors.lastname: Herendeen
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Kyla
authors.initials: K
authors.lastname: Gallacher
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Dottie
authors.initials: D
authors.lastname: Paquin
authors.affiliation: Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Compton
authors.affiliation: Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
authors.forename: Bishwabhusan
authors.initials: B
authors.lastname: Sahoo
authors.affiliation: Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
authors.forename: Sean A
authors.initials: SA
authors.lastname: Kerrigan
authors.affiliation: Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Burge
authors.affiliation: Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Nickels
authors.affiliation: Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Green
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
authors.forename: John A
authors.initials: JA
authors.lastname: Katzenellenbogen
authors.affiliation: Cambridge Major Laboratories, Inc., W130 N10497 Washington Drive, Germantown, Wisconsin 53022, United States.
authors.forename: Alexei
authors.initials: A
authors.lastname: Tchesnokov
authors.affiliation: Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Gary
authors.initials: G
authors.lastname: Hattersley
keywords: Androgen; Herschberger assay; SARM; cachexia; oxadiazole; primate