title: Single-fraction stereotactic body radiation therapy for sinonasal malignant melanoma.
abstract: BACKGROUND
  A rare head and neck disease that may benefit from definitive or palliative stereotactic body radiation therapy (SBRT) is sinonasal malignant melanoma. These tumors can be very aggressive and often lead to severe epistaxis and significant mass effect. Results from only a handful of head and neck sinonasal malignant melanoma treated with SBRT are available in the current literature.
  
  
  METHODS
  The following reports on 2 cases of sinonasal malignant melanoma that recurred postoperatively and were subsequently treated at Roswell Park with SBRT. Both were treated with a single fraction of 15 Gy.
  
  
  RESULTS
  Nearly instant relief of their chronic epistaxis and complete responses were seen in both patients. One patient is alive and free of disease 7 years after radiation.
  
  
  CONCLUSIONS
  These patients with sinonasal malignant melanoma achieved symptomatic relief of severe bleeding and airway issues from single-fraction SBRT. SBRT should be considered as a treatment option in patients with unresectable sinonasal malignant melanoma.
authors.affiliation: University at Buffalo School of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Bourgeois
authors.forename: Anurag K
authors.initials: AK
authors.lastname: Singh
mesh_terms: D000369:Aged, 80 and over; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D012086:Reoperation; D018570:Risk Assessment; D012494:Sampling Studies; D016896:Treatment Outcome
keywords: melanoma; mucosal; single-fraction; sinonasal; stereotactic body radiation therapy (SBRT)