title: General catalytic methylation of amines with formic acid under mild reaction conditions.
abstract: A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [N-(13)C]-labelled drugs in good to excellent yields under mild conditions.
authors.affiliation: Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert Einstein Str. 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000.
authors.forename: Iván
authors.initials: I
authors.lastname: Sorribes
authors.forename: Kathrin
authors.initials: K
authors.lastname: Junge
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D000588:Amines; D005561:Formates; C030544:formic acid
keywords: formic acid; homogeneous catalysis; methylation; platinum; silanes