title: Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice.
abstract: OBJECTIVE
  Bacopa monnieri (BM), a traditional ayurvedic medicine, is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice.
  
  
  METHODS
  Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze.
  
  
  RESULTS
  The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity.
  
  
  CONCLUSIONS
  BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status.
authors.affiliation: Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Verma
authors.affiliation: Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Singh
authors.affiliation: Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Behrose S
authors.initials: BS
authors.lastname: Gandhi
keywords: Bacopa monnieri; Oxidative stress; PBDE-209; Reference memory; Working memory