title: Elective neck irradiation versus observation in squamous cell carcinoma of the maxillary sinus with N0 neck: A meta-analysis and review of the literature.
abstract: BACKGROUND
  Elective neck irradiation of a clinical node-negative (N0) neck in squamous cell carcinoma (SCC) of the maxillary sinus is a controversial issue.
  
  
  METHODS
  A systematic review of electronic databases and a meta-analysis were conducted to clarify the role of elective neck irradiation in patients with SCC of the maxillary sinus and clinical N0 neck. Regional (neck) nodal recurrence was chosen as the primary endpoint.
  
  
  RESULTS
  Four retrospective studies with a total of 129 patients met the inclusion criteria. The results of the meta-analysis showed that elective neck irradiation reduced the risk of regional nodal recurrence (fixed effects model: odds ratio [OR] = 0.16; 95% confidence interval [CI] = 0.04-0.67; p = .01; random-effects model: OR = 0.17; 95% CI = 0.04-0.76; p = .02) compared to observation.
  
  
  CONCLUSIONS
  This systemic review and first meta-analysis confirmed that elective neck irradiation can significantly reduce the rate of nodal recurrence in patients with N0 SCC of the maxillary sinus.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Sara
authors.initials: S
authors.lastname: Abu-Ghanem
authors.affiliation: Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Gilad
authors.initials: G
authors.lastname: Horowitz
authors.affiliation: Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Avraham
authors.initials: A
authors.lastname: Abergel
authors.affiliation: Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Yehuda
authors.affiliation: Department of Radiation Oncology, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Orit
authors.initials: O
authors.lastname: Gutfeld
authors.affiliation: Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Narin-Nard
authors.initials: NN
authors.lastname: Carmel
authors.affiliation: Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Fliss
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D019317:Evidence-Based Medicine; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D037981:Neck Dissection / Q000379:methods*; D009367:Neoplasm Staging; D011880:Radiotherapy Planning, Computer-Assisted; D013997:Time Factors; D016896:Treatment Outcome; D057832:Watchful Waiting
keywords: elective neck irradiation; maxillary sinus; node negative (N0); review; squamous cell carcinoma (SCC)