title: The impact of selected preparations of trace elements - magnesium, potassium, calcium, and zinc on the release of diclofenac sodium from enteric coated tablets and from sustained release capsules.
abstract: BACKGROUND
  In an aging society, many patients require long-term treatment. This fact is associated clearly with the simultaneous occurrence of lifestyle diseases such as hypertension, diabetes, and even osteoarthritis. Concomitant medications, which are a common practice, pose a major threat of an interaction between these drugs. Very popular now "fast way of life" that makes people have less and less time to prepare well-balanced meals of high nutritional value. The result of this lifestyle is an increased need for supplementation preparations necessary vitamins and minerals. Given the wide availability of dietary supplements (shops, kiosks, petrol stations) raises the question about the possibility of an interaction between the uncontrolled intake of dietary supplements and medications received in the most common diseases of civilization.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effect of the most important minerals (magnesium, potassium, calcium, zinc) contained in the popular nutritional supplements, the release also often used as an anti-pain, anti-inflammatory, diclofenac sodium from the different formulations.
  
  
  RESULTS
  Among the many as sodium diclofenac selected two most common: film-coated tablets and sustained release capsules. The study showed a significant effect of minerals on the release of diclofenac sodium and differences that impact, depending on the test form of the drug.
authors.affiliation: Department of Pharmaceutical Technology, Wroclaw Medical University, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Biernat
authors.affiliation: Department of Pharmaceutical Technology, Wroclaw Medical University, Poland.
authors.forename: Witold
authors.initials: W
authors.lastname: Musiał
authors.affiliation: Department of Pharmaceutical Technology, Wroclaw Medical University, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Gosławska
authors.affiliation: Department of Pharmaceutical Technology, Wroclaw Medical University, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Pluta
mesh_terms: D002118:Calcium / Q000494:pharmacology; D002214:Capsules; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry*; D008274:Magnesium / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012995:Solubility; D013608:Tablets, Enteric-Coated; D014131:Trace Elements / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D013608:Tablets, Enteric-Coated; D014131:Trace Elements; D004008:Diclofenac; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium