title: Adiponectin, interleukin-6, monocyte chemoattractant protein-1, and regional fat mass during 12-month randomized treatment with metformin and/or oral contraceptives in polycystic ovary syndrome.
abstract: BACKGROUND
  Central obesity in polycystic ovary syndrome (PCOS) is associated with increased inflammatory markers and increased risk for type 2 diabetes.
  
  
  OBJECTIVE
  To evaluate if improved body composition during treatment with metformin (M) vs. oral contraceptive pills (OCP) was associated with changes in circulating adiponectin, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1.
  
  
  METHODS
  Ninety patients with PCOS were randomized to 12-month treatment with M (2 g/day), M + OCP (150 mg desogestrel + 30 microgram ethinylestradiol) or OCP. Adiponectin, IL-6, MCP-1, whole body DXA scans, and clinical evaluations were performed before and after the intervention period in the 65 study completers.
  
  
  METHODS
  Changes in inflammatory markers and changes in total and regional fat mass estimates.
  
  
  RESULTS
  Adiponectin, IL-6, and MCP-1 levels were unchanged during the three types of medical intervention. Treatment with M and M + OCP was superior to OCP regarding decreased regional fat mass. Baseline adiponectin and IL-6 were associated with BMI, waist, and trunk fat mass. Changes in trunk fat were significantly associated with changes in IL-6 and MCP-1 during M + OCP.
  
  
  CONCLUSIONS
  Long-term treatment with M alone or in combination with OCP was associated with improved body composition compared to OCP, whereas inflammatory markers were unchanged. OCP was not associated with increased inflammatory markers despite a small but significant weight gain.
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 3rd floor, 5000, Odense C, Denmark. dorte.glintborg@rsyd.dk.
authors.forename: Dorte
authors.initials: D
authors.lastname: Glintborg
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 3rd floor, 5000, Odense C, Denmark.
authors.forename: Hanne
authors.initials: H
authors.lastname: Mumm
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 3rd floor, 5000, Odense C, Denmark.
authors.forename: Magda Lambaa
authors.initials: ML
authors.lastname: Altinok
authors.affiliation: Department of Internal Medicine and Endocrinology (MEA), Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Bjørn
authors.initials: B
authors.lastname: Richelsen
authors.affiliation: Department of Internal Medicine and Endocrinology (MEA), Aarhus University Hospital, Aarhus, Denmark.|Medical Department, Regional Hospital Randers, Randers, Denmark.
authors.forename: Jens Meldgaard
authors.initials: JM
authors.lastname: Bruun
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 3rd floor, 5000, Odense C, Denmark.
authors.forename: Marianne
authors.initials: M
authors.lastname: Andersen
mesh_terms: D050153:Abdominal Fat / Q000000981:diagnostic imaging / Q000187:drug effects; D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000187:drug effects*; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D018932:Chemokine CCL2 / Q000097:blood*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000627:therapeutic use*; D017135:Desogestrel / Q000009:adverse effects / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood*; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use; D056128:Obesity, Abdominal / Q000150:complications; D010352:Patient Dropouts; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D015430:Weight Gain / Q000187:drug effects; D051598:Whole Body Imaging; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D003277:Contraceptives, Oral, Combined; D007004:Hypoglycemic Agents; C508600:IL6 protein, human; D015850:Interleukin-6; C442659:ethinyl estradiol-desogestrel combination; D004997:Ethinyl Estradiol; D017135:Desogestrel; D008687:Metformin