title: Mortality in hypertensive patients with coronary heart disease depends on chronopharmacotherapy and dipping status.
abstract: BACKGROUND
  The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality.
  
  
  METHODS
  Subjects with established coronary heart disease (CHD) (n = 1345, mean age 63.2 ± 9.2 years) were included.
  
  
  RESULTS
  Non-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00-4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02-1.47) and non-nighttime antihypertensive drug administration (HR 1.13, 95% CI 1.01-1.45) were predictors of all-cause mortality.
  
  
  CONCLUSIONS
  The non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime.
authors.affiliation: I Department of Cardiology, Medical University of Gdansk, Gdańsk, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Sobiczewski
authors.affiliation: Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland. Electronic address: marwirt@interia.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Wirtwein
authors.affiliation: I Department of Cardiology, Medical University of Gdansk, Gdańsk, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Gruchała
authors.affiliation: Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kocić
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents
keywords: Blood pressure profile; Chronopharmacotherapy; Coronary heart disease; Hypertension; Non-dippers