title: Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra.
abstract: Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.
authors.affiliation: Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno , CZ-612 42 Brno, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Zelová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Hanáková
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Čermáková
authors.forename: Karel
authors.initials: K
authors.lastname: Šmejkal
authors.forename: Stefano
authors.initials: S
authors.lastname: Dalĺ Acqua
authors.forename: Petr
authors.initials: P
authors.lastname: Babula
authors.forename: Josef
authors.initials: J
authors.lastname: Cvačka
authors.forename: Jan
authors.initials: J
authors.lastname: Hošek
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D016328:NF-kappa B / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D001578:Benzopyrans; D005419:Flavonoids; D008070:Lipopolysaccharides; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C542041:cudraflavone B; C576719:morusinol