title: Effect of Hypericum perforatum on intraperitoneal adhesion formation in rats.
abstract: BACKGROUND
  The aim of this study was to evaluate the efficacy of Hypericum perforatum for prevention of adhesion formation in rats.
  
  
  METHODS
  Twenty-four female wistar rats underwent left uterine horn adhesion model. Rats were randomised into 4 groups. Group 1 (Control): Closure of abdominal incision without any agent administration. Group 2: Closure of incision after administration of intraperitoneal (i.p.) Ringer's lactate solution. Group 3: Closure of incision after administration of i.p. olive oil (diluent of H. perforatum). Group 4: Hypericum perforatum extract (Ecodab(®)) was administered i.p. before the closure of incision. Fourteen days later, relaparatomy was performed and surgical adhesion scores, inflammation and fibrosis scores were noted. Groups were compared according to these scores.
  
  
  RESULTS
  There was statistical significant difference between ringer's lactate group and olive oil group according to surgical adhesion score (p = 0.009). However, groups were not different according to inflammation and fibrosis scores (p > 0.05).
  
  
  CONCLUSIONS
  Despite antiinflammatory, antioxidants and antimicrobial properties of H. perforatum, our results revealed no positive effect of H. perforatum on the prevention of intraperitoneal adhesion formation.
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University Faculty of Medicine, Ankara, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Hızlı
authors.affiliation: Department of Urology, Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Hızlı
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University Faculty of Medicine, Ankara, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Köşüş
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Saynur
authors.initials: S
authors.lastname: Yılmaz
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University Faculty of Medicine, Ankara, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Köşüş
authors.affiliation: Department of Pathology, Fatih University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hacer
authors.initials: H
authors.lastname: Haltaş
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Dede
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kafalı
keywords: Hypericum perforatum; St. John's wort; intraperitoneal adhesion; prevention; rat