title: Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines.
abstract: Two new compounds, derrivanone (1) and derrischalcone (2), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2-4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors.forename: Phatharapoll
authors.initials: P
authors.lastname: Decharchoochart
authors.forename: Jittra
authors.initials: J
authors.lastname: Suthiwong
authors.forename: Papavee
authors.initials: P
authors.lastname: Samatiwat
authors.forename: Veerapol
authors.initials: V
authors.lastname: Kukongviriyapan
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity*; D001650:Bile Duct Neoplasms / Q000188:drug therapy; D001653:Bile Ducts, Intrahepatic; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry; D018281:Cholangiocarcinoma / Q000188:drug therapy; D029866:Derris / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000633:toxicity; D005638:Fruit / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; D044950:Flavanones; D010936:Plant Extracts; C000593755:derrischalcone; C000593753:derrivanone