title: Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with (18)F-FDG PET/CT.
abstract: Tetrasomy 8 is a relatively rare chromosomal abnormality that has been reported in only 33 cases in hematologic disorders. It is known for its association with aggressive acute myeloid leukemia (AML) and myeloid sarcoma and is considered a very poor prognostic factor. Myeloid sarcoma is a rare hematologic malignancy characterized by tumor masses consisting of immature myeloid cells, presenting at an extramedullary site. We present a case of a 17-year-old boy referred for an (18)F-FDG PET/CT for the evaluation of pleural masses and spinal bone lesions seen on CT, after presenting with a 4 month history of chest pain. The PET/CT revealed extensive FDG-avid extramedullary disease in the soft tissues of the chest, abdomen, and pelvis, which were biopsy-proven to be myeloid sarcoma, as well as extensive intramedullary disease biopsy proven to be AML. This is the first report of the use of (18)F-FDG PET/CT to stage a subset of aggressive AML and myeloid sarcoma in a patient with an associated chromosomal abnormality (tetrasomy 8).
authors.affiliation: Department of Nuclear Medicine, Brandon Regional Health Centre, 150 McTavish Ave E, Brandon, MB R7A 2B3 Canada.
authors.forename: William
authors.initials: W
authors.lastname: Makis
authors.affiliation: Department of Nuclear Medicine, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Ave West, M2, Montreal, QC H3A 1A1 Canada.
authors.forename: Rajan
authors.initials: R
authors.lastname: Rakheja
authors.affiliation: Department of Pathology, Montreal Children's Hospital, McGill University Health Centre, 2300 Tupper St, Montreal, QC H3H 1P3 Canada.
authors.forename: Josee
authors.initials: J
authors.lastname: Lavoie
authors.affiliation: Department of Nuclear Medicine, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Ave West, M2, Montreal, QC H3A 1A1 Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Hickeson
keywords: Extramedullary AML; FDG; Fluorodeoxyglucose; Granulocytic sarcoma; Myeloid sarcoma; PET/CT; Tetrasomy 8