title: The use of hyaluronic acid after tendon surgery and in tendinopathies.
abstract: Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English-language articles was performed using the key search terms "hyaluronic acid" or "viscosupplementation" combined with "tendon," "tendinopathy," "adhesions," or "gliding," independently. In quite all the experimental studies, performed after surgical procedures for tendon injuries or in the treatment of chronic tendinopathies, using different hyaluronic acid compounds, positive results (reduced formation of scars and granulation tissue after tendon repair, less adhesions and gliding resistance, and improved tissue healing) were observed. In a limited number of cases, hyaluronic acid has been employed in clinical practice. After flexor tendon surgery, a greater total active motion and fingers function, with an earlier return to work and daily activities, were observed. Similarly, in patients suffering from elbow, patellar, and shoulder tendons disorders, pain was reduced, and function improved. The positive effect of hyaluronic acid can be attributed to the anti-inflammatory activity, enhanced cell proliferation, and collagen deposition, besides the lubricating action on the sliding surface of the tendon.
authors.affiliation: Department of Medicine and Science of Aging, University G. d'Annunzio, Chieti-Pescara, Via dei Vestini 31, 66013 Chieti, Italy.
authors.forename: Michele
authors.identifier: 0000-0002-6668-8034
authors.initials: M
authors.lastname: Abate
authors.affiliation: Department of Medicine and Science of Aging, University G. d'Annunzio, Chieti-Pescara, Via dei Vestini 31, 66013 Chieti, Italy.
authors.forename: Cosima
authors.initials: C
authors.lastname: Schiavone
authors.affiliation: Department of Medicine and Science of Aging, University G. d'Annunzio, Chieti-Pescara, Via dei Vestini 31, 66013 Chieti, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Salini
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D052256:Tendinopathy / Q000188:drug therapy* / Q000601:surgery*; D013710:Tendons / Q000473:pathology / Q000601:surgery*
chemical_list: D006820:Hyaluronic Acid