title: Regulation of immune responses by proton channels.
abstract: The identification of the HVCN1 gene, encoding the only mammalian voltage-gated proton channel, prompted a number of studies on how proton channels affect cellular functions. As their expression is mainly restricted to immune cells, it is not surprising that proton channels regulate different aspects of immune responses. In this review, I will examine the current knowledge of voltage-gated proton channels in both innate and adaptive responses and assess the remaining outstanding questions.
authors.affiliation: Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London, UK.
authors.forename: Melania
authors.initials: M
authors.lastname: Capasso
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D015640:Ion Channel Gating; D007473:Ion Channels / Q000276:immunology / Q000378:metabolism*; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D011522:Protons; D015398:Signal Transduction
chemical_list: C510235:HVCN1 protein, human; D007473:Ion Channels; D011522:Protons
keywords: HVCN1; Hv1; leucocytes; lymphocyte activation; proton channel