title: Fluorescent studies on the interaction of DNA and ternary lanthanide complexes with cinnamic acid-phenanthroline and antibacterial activities testing.
abstract: Twelve lanthanide complexes with cinnamate (cin(-) ) and 1,10-phenanthroline (phen) were synthesized and characterized. Their compositions were assumed to be RE(cin)3 phen (RE(3+)  = La(3+) , Pr(3+) , Nd(3+) , Sm(3+) , Eu(3+) , Gd(3+) , Tb(3+) , Dy(3+) , Ho(3+) , Tm(3+) , Yb(3+) , Lu(3+) ). The interaction mode between the complexes and DNA was investigated by fluorescence quenching experiment. The results indicated the complexes could bind to DNA and the main binding mode is intercalative binding. The fluorescence quenching constants of the complexes increased from La(cin)3 phen to Lu(cin)3 phen. Additionally, the antibacterial activity testing showed that the complexes exhibited excellent antibacterial ability against Escherichia coli, and the changes of antibacterial ability are in agreement with that of the fluorescence quenching constants.
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Huhhot, 010021, China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Sun
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Wang
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Chu
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D005453:Fluorescence; D028581:Lanthanoid Series Elements / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002934:Cinnamates; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D010618:Phenanthrolines; C029010:cinnamic acid; D004247:DNA; C427203:calf thymus DNA
keywords: 1,10-phenanthroline; DNA-binding; antibacterial activities; cinnamic acid; lanthanide complexes