title: Cyclodextrin complexed [60]fullerene derivatives with high levels of photodynamic activity by long wavelength excitation.
abstract: We have evaluated the photodynamic activities of C60 derivative·γ-cyclodextrin (γ-CDx) complexes and demonstrated that they were significantly higher than those of the pristine C60 and C70·γ-CDx complexes under photoirradiation at long wavelengths (610-720 nm), which represent the optimal wavelengths for photodynamic therapy (PDT). In particular, the cationic C60 derivative·γ-CDx complex had the highest photodynamic ability because the complex possessed the ability to generate high levels of (1)O2 and provided a higher level of intracellular uptake. The photodynamic activity of this complex was greater than that of photofrin, which is the most widely used of the known clinical photosensitizers. These findings therefore provide a significant level of information toward the optimization of molecular design strategies for the synthesis of fullerene derivatives for PDT.
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Iizuka
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Naotake
authors.initials: N
authors.lastname: Maekubo
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Aono
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kikuchi
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
authors.affiliation: Department of Chemistry, College of Engineering, Shibaura Institute of Technology , 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Konishi
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ishida-Kitagawa
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tatebe
authors.affiliation: Graduate School of Materials Science and Graduate School of Biological Sciences, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shiozaki
keywords: Fullerenes; cyclodextrin; photodynamic therapy; photosensitizers