title: Amnesic effects of electroshock and anoxia on conditioned taste aversion learning in rats.
abstract: Albino Wistar rats of both sexes were given a conditioned taste aversion training (CTA). Saccharin was used as the conditional stimulus (CS) and apomorphine-induced illness as the unconditional stimulus (US) on day 4. Amnestic treatment with electroconvulsive shock (ECS) or nitrogen anoxia were given to the rats at various points within the 180-min long CS-US interval as well as after the US. They were reexposed to the CS on days 5 and 6 in order to evaluate CTA and its extinction respectively. Apomorphine injection alone produced significant CTA as long as the CS-US interval was less than 120 min but not beyond it. Saline injections, with or without amnestic treatments, produced only an adaptation to and preference for saccharin. ECS could prevent CTA when delivered within 85 min before or 110 min after the US. Anoxia was effective at a much shorter range of time than ECS. The results are discussed in the perspectives of neophobia, saccharin aversion, amnestic agents and the character as well as gradients of amnesia produced.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur Malaysia.
authors.forename: U
authors.initials: U
authors.lastname: Banerjee
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur Malaysia.
authors.forename: P
authors.initials: P
authors.lastname: Das