title: Is there any relationship between cardiovascular risk markers and young women with diminished ovarian reserve?
abstract: OBJECTIVE
  It has been widely known that cardiovascular disease (CVD) risk is increased in menopause. The aim of the study was to evaluate whether this risk was elevated in young women with diminished ovarian reserve (DOR).
  
  
  METHODS
  A hundred women with DOR and 100 women with normal ovarian reserve (NOR) attending the infertility unit at Suleymaniye Maternity, Research &Training Hospital, were enrolled in the study. CVD risk markers such as insulin resistance (defined by the homeostasis model assessment ratio [HOMA-IR]), C-reactive protein (CRP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and triglyceride (TG) were assessed.
  
  
  RESULTS
  HOMA-IR, CRP, TG, LDL levels were higher and HDL was lower among patients with DOR compared to the controls (p < 0.05 for all). There were positive associations between DOR and HOMA-IR, CRP, TG, LDL levels and a negative correlation with HDL (p < 0.05 for all). However, multivariate logistic regression analysis showed that HOMA-IR, CRP, TG, and HDL were independent variables that were associated with DOR.
  
  
  CONCLUSIONS
  CVD risk markers were increased in women with DOR. Further studies with larger groups are needed to investigate the nature of the link in these patients.
authors.affiliation: Department of Obstetrics & Gynecology, Infertility Research & Treatment Center, Suleymaniye Maternity, Research & Training Hospital , Istanbul , Turkey and.
authors.forename: Fatma Ferda
authors.initials: FF
authors.lastname: Verit
authors.forename: Seda
authors.initials: S
authors.lastname: Keskin
authors.forename: Beyhan
authors.initials: B
authors.lastname: Omer
authors.forename: Sener
authors.initials: S
authors.lastname: Yalcinkaya
authors.forename: Nafi
authors.initials: N
authors.lastname: Sakar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood*; D065851:Ovarian Reserve / Q000502:physiology*; D012306:Risk
chemical_list: D015415:Biomarkers
keywords: C-reactive protein; Cardiovascular risk; diminished ovarian reserve; dyslipidemia; insulin resistance