title: Stenting for ST-segment elevation myocardial infarction is associated with less neointimal hyperplasia in the pooled IVUS analysis from HORIZONS-AMI and the TAXUS IV and V and ATLAS workhorse, long lesion, and direct stent studies.
abstract: OBJECTIVE
  To investigate the difference in neointimal hyperplasia (NIH) between ST-segment elevation myocardial infarction (STEMI), stable angina pectoris (SAP), and unstable angina pectoris (UAP).
  
  
  METHODS
  From formal core laboratory intravascular ultrasound substudies, we compared NIH after paclitaxel-eluting stents (PES) or bare metal stents (BMS) in STEMI lesions from HORIZONS-AMI trial with SAP and UAP lesions from TAXUS IV, V, and ATLAS studies.
  
  
  RESULTS
  At follow-up, %NIH at the minimum lumen area (MLA) site was less in STEMI (n=212) than in UAP (n=233) and SAP (n=440) lesions treated with PES (19.6 vs. 26.2 vs. 25.0%, P=0.002; all intravascular ultrasound data shown as least-square means in abstract) and less in STEMI (n=66) than in UAP (n=72) and SAP (n=143) lesions treated with BMS (34.0 vs. 26.7 vs. 45.5%, P=0.0003). As a result, MLA at follow-up was larger in STEMI than in UAP and SAP lesions treated with PES (5.9 vs. 5.2 vs. 5.0 mm, P<0.0001) or treated with BMS (5.1 vs. 4.3 vs. 4.0 mm, P=0.002). Net volume obstruction ([NIH/stent volume]×100) at follow-up was significantly less in STEMI than in UAP and SAP lesions treated with PES (7.8 vs. 13.4 vs. 13.4%, P<0.0001) or BMS (20.6 vs. 28.5 vs. 32.1%, P<0.0001). Multivariate linear regression analysis showed that STEMI was correlated independently and inversely with net volume obstruction compared with SAP (regression coefficient -6.99, P<0.0001) or UAP (regression coefficient -6.29, P<0.0001).
  
  
  CONCLUSIONS
  Implantation of PES or BMS in STEMI compared with UAP and SAP was associated with less NIH.
authors.affiliation: aNew York Presbyterian Hospital/Columbia University Medical Center bClinical Trials Center, Cardiovascular Research Foundation, New York, New York cBoston Scientific Corporation, Natick, Massachusetts dDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio eVascular Therapies, Covidien fGeorgetown University, Washington, District of Columbia gMedStar Health Research Institute, Hyattsville, Maryland, USA hAmper Kliniken AG, Dachau, Germany iCardiology Department, Auckland City Hospital, Auckland, New Zealand jInterventional Cardiology Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
authors.forename: Dominic
authors.initials: D
authors.lastname: Allocco
authors.forename: Bernard
authors.initials: B
authors.lastname: Witzenbichler
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ellis
authors.forename: Mark A
authors.initials: MA
authors.lastname: Turco
authors.forename: John A
authors.initials: JA
authors.lastname: Ormiston
authors.forename: Giulio
authors.initials: G
authors.lastname: Guagliumi
authors.forename: Songtao
authors.initials: S
authors.lastname: Jiang
authors.forename: Thomas C
authors.initials: TC
authors.lastname: McAndrew
authors.forename: Keith D
authors.initials: KD
authors.lastname: Dawkins
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Weissman
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000473:pathology / Q000628:therapy*; D000789:Angina, Unstable / Q000473:pathology / Q000628:therapy*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D058426:Neointima / Q000000981:diagnostic imaging / Q000473:pathology*; D017239:Paclitaxel; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D050257:Tubulin Modulators; D018084:Ultrasonography, Interventional
chemical_list: D050257:Tubulin Modulators; D017239:Paclitaxel