title: Individual investigator profiles of biospecimen use in cancer research.
abstract: BACKGROUND
  Establishing targets for case accrual is an important component of a strategic plan for a biobank. We have previously assessed overall patterns of biospecimen use in cancer research publications in selected journals. Here we extend this analysis to consider patterns of biospecimen use in relation to cancer research programs developed by individual investigators.
  
  
  METHODS
  We selected three individual cancer research investigators whose independent research programs began circa 1986, have been characterized by extensive use of human tumor biospecimens, and have primarily involved translational research in the areas of breast, lung, and ovarian cancer. We analyzed biospecimen and data usage in their career publications categorized by numbers, type, and format, and accompanying annotating data in terms of conformance with BRISQ reporting and ethics related criteria.
  
  
  RESULTS
  Biospecimens were used in 313/474 (66%) of publications analyzed. The average number of biospecimens used by these research programs increased six-fold from less than 1000 in 2001-2003 to greater than 6000 in 2010-2012, and the average cohort sizes per article also increased from approximately 50 to 200 cases per study over the same period in most biospecimen categories (p<0.05). The relative proportions of different formats of biospecimens used has varied significantly and continues to change with the emergence of digital biospecimen derived data. In these three translational research programs, BRISQ elements relating to 'Biobank' categories were significantly less well reported for biospecimens used in publications than data corresponding to 'Clinical chart' categories (p<0001).
  
  
  CONCLUSIONS
  This study shows that overall use of biospecimens in cancer research has increased significantly and that dynamic variation in the relative use of different biospecimen formats has also occurred. This study also confirms our previous findings on patterns of biospecimen use and also those concerning incomplete reporting of relevant data elements that has not improved in the past decade.
authors.affiliation: 1 Tumour Tissue Repository, Trev and Joyce Deeley Research Centre, BC Cancer Agency , Victoria, British Columbia, Canada .
authors.forename: Lauren
authors.initials: L
authors.lastname: Braun
authors.forename: Maria
authors.initials: M
authors.lastname: Lesperance
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Mes-Massons
authors.forename: Ming S
authors.initials: MS
authors.lastname: Tsao
authors.forename: Peter H
authors.initials: PH
authors.lastname: Watson
mesh_terms: D018070:Biological Specimen Banks; D035843:Biomedical Research / Q000706:statistics & numerical data; D016206:Databases, Bibliographic; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D012108:Research Personnel; D013048:Specimen Handling / Q000706:statistics & numerical data / Q000639:trends