title: Sex-related differences in spatial learning during the early postnatal development of the rat.
abstract: Some authors have reported that male rats younger than 21 days old are unable to perform spatial learning correctly because they have still not developed the ability to use extra-maze cues. In experiment 1, we analyzed spatial learning in 14-, 21-, 30- and 42-day-old rats using the Morris water maze (MWM). According to our results, a good performance was observed in 30-day-old male rats whereas this was not observed in female rats until they were 42 days old. In experiment 2 we studied the role of sex hormones in this kind of learning using the MWM and 30-day-old rats (castrated male rats and female rats treated with testosterone propionate (TP) after birth). The latter group, the male control group and the castrated males all solved the task correctly. The objective of experiment 3 was to determine possible differences between the sexes in the use of taxon strategies in the T water maze. To summarize, sexual dimorphism was only observed in spatial learning during development.
authors.affiliation: Laboratorio de Psicobiologı́a, Facultad de Psicologı́a, Universidad de Oviedo, E-33003 Oviedo, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Cimadevilla
authors.affiliation: Laboratorio de Psicobiologı́a, Facultad de Psicologı́a, Universidad de Oviedo, E-33003 Oviedo, Spain.
authors.forename: H
authors.initials: H
authors.lastname: González-Pardo
authors.affiliation: Laboratorio de Psicobiologı́a, Facultad de Psicologı́a, Universidad de Oviedo, E-33003 Oviedo, Spain.
authors.forename: L
authors.initials: L
authors.lastname: López
authors.affiliation: Departamento de Biologı́a Funcional (Area de Fisiologı́a), Universidad de Oviedo, Oviedo, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Diaz
authors.affiliation: Area de Metodologı́a, Facultad de Psicologı́a, Universidad de Oviedo, Oviedo, Spain.
authors.forename: E G
authors.initials: EG
authors.lastname: Cueto
authors.affiliation: Departamento de Psicobiologı́a, Facultad de Psicologı́a, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: L M
authors.initials: LM
authors.lastname: Garcia-Moreno
authors.affiliation: Laboratorio de Psicobiologı́a, Facultad de Psicologı́a, Universidad de Oviedo, E-33003 Oviedo, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Arias