title: Intra-operative ultrasound versus wire-guided localization in the surgical management of non-palpable breast cancer.
abstract: BACKGROUND
  Non-palpable breast lesions require some method of localization when performing breast conserving surgery (BCS). Despite the advent of newer techniques, ultrasound (US) and wire-guided localization (WGL) remain the most popular approaches.
  
  
  OBJECTIVE
  We aim to compare the positive margin rate of US versus WGL in the excision of breast lesions.
  
  
  METHODS
  Data were collected from the Clinical Access Portal. All patients who underwent US or WGL BCS were identified and consecutive data collected. Positive margins were evaluated using histopathology reports. Baseline demographics and specimen size data were also collected.
  
  
  RESULTS
  A total of 198 patients were included in total over a three-year period. There was some evidence of an association of type of surgery with positive margin (OR=2.11, p=0.075) where a 2.11 fold increase in the odds of a positive margin was estimated for the US method relative to WGL, but this was not statistically significant at the 5% level. This effect decreased after adjusting for potential confounders (OR=1.81, p=0.34).
  
  
  CONCLUSIONS
  This retrospective study of US versus WGL in BCS demonstrated no significant difference in the positive margin rate, although a trend was observed in favor of the WGL group. We have provided further evidence for the debate on the accuracy of US and WGL for non-palpable breast lesions. Available data remains sparse, and our results contradict the findings of other comparative studies.
authors.affiliation: Calvary Mater Breast Unit, Calvary Mater Hospital, Waratah, NSW, Australia.
authors.forename: Owen James
authors.initials: OJ
authors.lastname: Morris
authors.affiliation: Hunter New England Area Health, New Lambton Heights, NSW, Australia.
authors.forename: Veronica
authors.initials: V
authors.lastname: Knight
authors.affiliation: Calvary Mater Breast Unit, Calvary Mater Hospital, Waratah, NSW, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Logan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional
keywords: Ultrasound; breast cancer; breast conserving surgery; margin status; radiological localization; wire localization