title: Intracisternal injection of palmitoylethanolamide inhibits the peripheral nociceptive evoked responses of dorsal horn wide dynamic range neurons.
abstract: Endogenous palmitoylethanolamide (PEA) has a key role in pain modulation. Central or peripheral PEA can reduce nociceptive behavior, but no study has yet reported a descending inhibitory effect on the neuronal nociceptive activity of Aδ- and C-fibers. This study shows that intracisternal PEA inhibits the peripheral nociceptive responses of dorsal horn wide dynamic range cells (i.e., inhibition of Aδ- and C-fibers), an effect blocked by spinal methiothepin. These results suggest that a descending analgesic mechanism mediated by the serotonergic system could be activated by central PEA.
authors.affiliation: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Boulevard Juriquilla 3001, 76230, Querétaro, Mexico.
authors.forename: Abimael
authors.initials: A
authors.lastname: González-Hernández
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Martínez-Lorenzana
authors.forename: Javier
authors.initials: J
authors.lastname: Rodríguez-Jiménez
authors.forename: Gerardo
authors.initials: G
authors.lastname: Rojas-Piloni
authors.forename: Miguel
authors.initials: M
authors.lastname: Condés-Lara
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000577:Amides; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D004983:Ethanolamines / Q000494:pharmacology*; D007796:Laminectomy; D008297:Male; D008719:Methiothepin / Q000494:pharmacology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects*; D010169:Palmitic Acids / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D066148:Spinal Cord Dorsal Horn / Q000166:cytology*; D013346:Subarachnoid Space / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D000577:Amides; D000700:Analgesics; D004983:Ethanolamines; D010169:Palmitic Acids; D012702:Serotonin Antagonists; D008719:Methiothepin; C005958:palmidrol