title: GNB3 gene c.825C>T polymorphism and performance parameters in professional basketball players.
abstract: This study has been conducted to determine whether mean values of peak oxygen consumption (VO(2peak)), anaerobic test parameters and knee isokinetic test measurements are different among guanine nucleotide-binding protein, beta-3 (GNB3) genotype groups in a group of basketball players.
  
  
  METHODS
  Seventy-two healthy male (mean age, 22.9 ± 5.3 years) basketball players from the first division of national league participated. We studied GNB3 gene c.825C>T (rs5443) polymorphism, then divided the subjects into three groups as CC (n = 21), CT (n = 35), and TT (n =1 6). Mean VO(2peak), Wingate anaerobic test results, and isokinetic knee muscle strength measurements were compared among the genotype groups.
  
  
  RESULTS
  Mean VO(2peak) (60.1 ± 3.9; 56.7 ± 3.6; and 57.8 ± 3.3, respectively, p < 0.01), mean anaerobic minimum power (5.1 ± 0.4; 5.3 ± 0.5; and 4.4 v 0.5 W/kg, respectively, p < 0.001), mean anaerobic power drop (57.0 ± 6.2; 54.2 ± 6.9; and 62.9 ± 5.3%, respectively, p < 0.001) were significantly different among the study groups, CC, CT, and TT. Individuals with TT genotype exerted lower performance in terms of isokinetic knee muscle strength.
  
  
  CONCLUSIONS
  The presence of 825T-allele may impair athletic performance and may serve as a genetic marker of low capacity for athletic performance in male basketball players.
authors.affiliation: Trakya University Faculty of Medicine, Department of Biophysics Edirne Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Gülyaşar
authors.affiliation: Trakya University Faculty of Medicine, Department of Physiology Edirne Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Oztürk
authors.affiliation: Trakya University Faculty of Medicine, Department of Biophysics Edirne Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Sipahi
authors.affiliation: Istanbul University Faculty of Medicine, Department of Sports Medicine Istanbul Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Bayraktar
authors.affiliation: Istanbul University Faculty of Medicine, Department of Sports Medicine Istanbul Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Metin
authors.affiliation: Istanbul University Physical Education and Sports School Istanbul Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Yücesir
authors.affiliation: Trakya University Faculty of Medicine, Department of Biostatistics Edirne Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Süt
mesh_terms: D000293:Adolescent; D000328:Adult; D054874:Athletic Performance; D001490:Basketball; D005080:Exercise Test; D005787:Gene Frequency; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000235:genetics; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000378:metabolism*; D010101:Oxygen Consumption / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins
keywords: GNB3; VO2peak; exercise capacity; genetic polymorphism; isokinetic knee strength