title: Improving the plausibility of success with inefficient metrics.
abstract: To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against these properties could help reach drug-like space more efficiently. Potential reasons for the inefficient use of metrics and suboptimal decision making are discussed.
authors.affiliation: Novartis Institutes for Biomedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Shultz
keywords: Ligand efficiency (LE); decision making; drug-likeness; efficiency metrics; fragment-based drug design; lipophilic efficiency (LipE)