title: Endothelial function in hypertensive obese patients: 1 year after surgically induced weight loss.
abstract: The aim of this study was to describe the effect of surgically induced weight loss on vascular function measured by flow-mediated dilatation (FMD) in hypertensive obese patients. This prospective study included 33 patients (78 % females, mean age 53 (9) years) undergoing bariatric surgery (BS). Before and 12 months postoperatively, the BMI, 24-h ambulatory BP, high-sensitivity C-reactive protein (hs-CRP), leptin, homeostasis model assessment (HOMA IR), and abdominal fat were measured. Endothelial function was assessed by FMD. After BS, the excess body weight loss was 71 %; the 24-h [systolic 18(11)//diastolic 7(7) mmHg] BP values, hs-CRP, leptin, HOMA, and abdominal fat significantly decreased, with no changes in endothelial function. Weight loss achieved by BS was associated with a significant improvement in BP and metabolic and inflammation parameters, but FMD did not improve.
authors.affiliation: Obesity Unit, Department of Endocrinology and Nutrition, Hospital Clinic i Universitari, Villarroel, 170, Escalera 11, 2º piso, CP 08036, Barcelona, Spain, lflores@clinic.ub.es.
authors.forename: L
authors.initials: L
authors.lastname: Flores
authors.forename: I
authors.initials: I
authors.lastname: Núñez
authors.forename: J
authors.initials: J
authors.lastname: Vidal
authors.forename: S
authors.initials: S
authors.lastname: Rueda
authors.forename: J
authors.initials: J
authors.lastname: Viaplana
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Esmatjes
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D050110:Bariatric Surgery; D018660:Blood Pressure Monitoring, Ambulatory; D002097:C-Reactive Protein / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome; D014664:Vasodilation / Q000502:physiology*; D015431:Weight Loss
chemical_list: D020738:Leptin; D002097:C-Reactive Protein