title: [ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].
abstract: Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase belonging to the mitogen-activated protein kinase (MAPK) kinase kinase family. ASK1 is activated in response to various stresses, such as reactive oxygen species (ROS), tumor necrosis factor (TNF) alpha, lipopolysaccharide (LPS) and endoplasmic reticulum (ER) stress, and plays pivotal roles in a wide variety of cellular responses, including cell death, differentiation and inflammation. Recent studies have shown that ASK1-MAPK signaling pathway has key roles in human diseases induced by the dysfunction of cellular stress responses. In this review, we provide an overview of the current understanding of ASK1 as a potential therapeutic target for human diseases.
authors.forename: Takao
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ichijo
mesh_terms: D000818:Animals; D016923:Cell Death / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D055808:Drug Discovery; D059865:Endoplasmic Reticulum Stress; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000235:genetics*; D008070:Lipopolysaccharides; D048848:MAP Kinase Kinase Kinase 5 / Q000378:metabolism / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D058990:Molecular Targeted Therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics*; D018384:Oxidative Stress / Q000235:genetics; D017382:Reactive Oxygen Species; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha
chemical_list: D004791:Enzyme Inhibitors; D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D048848:MAP Kinase Kinase Kinase 5