title: Advances in processes for PET radiotracer synthesis: separation of [¹⁸F]fluoride from enriched [¹⁸O]water.
abstract: Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [(18)F]fluorodeoxyglucose ([(18)F]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [(18)F]fluoride from [(18)O]water. There are many methods reported in literature for the isolation of [(18)F]fluoride, including evaporation, coat-capture-elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [(18)F]fluoride ions from [(18)O]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of (18)F PET tracers.
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Haswell
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
authors.forename: Nicole
authors.initials: N
authors.lastname: Pamme
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK; Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull HU6 7RX, UK. Electronic address: s.j.archibald@hull.ac.uk.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Archibald
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry / Q000302:isolation & purification*; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis; D006801:Humans; D010103:Oxygen Isotopes / Q000737:chemistry / Q000302:isolation & purification; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Electrochemical cell; FDG; Fluorine-18; Positron emission tomography; Radiochemical synthesis; Separation