title: Relationship of the FKBP5 C/T polymorphism with dysfunctional attitudes predisposing to depression.
abstract: FK506-binding protein 51 (FKBP5) is a co-chaperone of the glucocorticoid receptor, and plays an important role in the negative feedback regulation of the hypothalamic-pituitary-adrenal axis. The C/T single nucleotide polymorphism in the intron 2 of the FKBP5 gene affects cortisol secretion, and has been implicated in the pathophysiology of depression. In this study, the relationship of the FKBP5 C/T polymorphism with dysfunctional attitudes predisposing to depression was examined. The subjects were 300 healthy Japanese. The FKBP5 genotypes were determined by a real-time PCR and cycling probe technology for SNP typing. Dysfunctional attitudes were assessed by the 24-item version of the Dysfunctional Attitude Scale (DAS-24), which has the Achievement, Self-control, and Dependency subscales. DAS-24 total scores were significantly higher in the group with the T allele than in that without this allele (p=0.001). Regarding the subscales, scores of the Achievement (p=0.003) and Self-control (p=0.009) subscales, but not those of the Dependency subscale, were significantly higher in the former group than in the latter group. The present study suggests that the FKBP5 C/T polymorphism is implicated in formation of dysfunctional attitudes, especially those about achievement and self-control.
authors.affiliation: Department of Psychiatry, Yamagata University School Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: suzukiakihito@hotmail.com.
authors.forename: Akihito
authors.initials: A
authors.lastname: Suzuki
authors.affiliation: Department of Psychiatry, Yamagata University School Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Matsumoto
authors.affiliation: Department of Psychiatry, Yamagata University School Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Sadahiro
authors.affiliation: Department of Psychiatry, Yamagata University School Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Enokido
authors.affiliation: Department of Anatomy and Cell Biology, Yamagata University School Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Goto
authors.affiliation: Department of Psychiatry, Yamagata University School Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000124:Achievement; D000328:Adult; D044466:Asian People / Q000235:genetics / Q000523:psychology / Q000706:statistics & numerical data; D001290:Attitude; D003596:Cytosine; D003858:Dependency, Psychological; D003863:Depression / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007389:Internal-External Control; D007564:Japan; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D022021:Tacrolimus Binding Proteins / Q000235:genetics* / Q000378:metabolism; D013941:Thymine; D000099159:Tacrolimus Binding Protein 5
chemical_list: D003596:Cytosine; D022021:Tacrolimus Binding Proteins; D013941:Thymine; D000099159:Tacrolimus Binding Protein 5