title: Lethal hepatocellular necrosis associated with herbal polypharmacy in a patient with chronic hepatitis B infection.
abstract: Following a short treatment for irritable bowel with the following herbs: Astragalus propinquus, Codonopsis pilosula, Paeonia sp., Atractylodes macrocephala, Pueraria sp., Poria cocos, Dioscorea opposita, Patriniae, Psoralea corylifolia, Alpinia katsumadai, Glycyrrhiza uralensis and Dolomiaea souliei sp. a 43-year-old woman developed acute severe liver failure requiring liver transplantation. Histopathological examination of the liver showed massive hepatic necrosis in keeping with drug/chemical toxicity. Surgery was followed by multiorgan failure and death. While numerous studies have evaluated the effect of polypharmacy, the study of multiple concurrent herb use is only just emerging, despite the popularity of herbal medicine use in the western world. As this case demonstrates that fulminant hepatic failure and death may be caused by the concomitant use of a number of herbal products, the possibility of untoward effects from herbal polypharmacy must be increasingly considered in the evaluation of medicolegal cases.
authors.affiliation: Forensic Science SA, Adelaide, SA 5000, Australia.
authors.forename: John D
authors.initials: JD
authors.lastname: Gilbert
authors.affiliation: School of Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Ian F
authors.initials: IF
authors.lastname: Musgrave
authors.affiliation: School of Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Claire
authors.initials: C
authors.lastname: Hoban
authors.affiliation: Forensic Science SA, Adelaide, SA 5000, Australia; School of Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: roger.byard@sa.gov.au.
authors.forename: Roger W
authors.initials: RW
authors.lastname: Byard
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D016031:Liver Transplantation; D047508:Massive Hepatic Necrosis / Q000139:chemically induced* / Q000473:pathology; D008517:Phytotherapy / Q000009:adverse effects*; D019338:Polypharmacy
keywords: Death; Hepatitis B; Herbal medicine; Liver failure; Polyherbacy; Polypharmacy