title: Non-specific psychological distress in women undergoing noninvasive prenatal testing because of advanced maternal age.
abstract: OBJECTIVE
  The objective of our study was to describe our clinical experience in providing noninvasive prenatal testing (NIPT) for fetal aneuploidy to pregnant women, highlighting the degree of non-specific psychological distress.
  
  
  METHODS
  Data were collected from Japanese women who were offered and underwent NIPT after genetic counseling and control pregnant women who did not undergo NIPT as part of the Japan Environment and Children's Study Control A planning. The degree of mental distress was assessed using the Kessler 6 (K6) screening scale with a score of ≥10 indicating depression or anxiety disorder.
  
  
  RESULTS
  Among the 505 women who underwent NIPT because of advanced maternal age, 9.1% had a K6 score of ≥10. Compared with matched controls (n = 1010) adjusted for maternal age and gestational age, the NIPT group showed a trend toward higher K6 scores (odds ratio 1.44, 95% confidence interval 0.97-2.13, P = 0.07). Higher K6 scores were associated with women whose husbands were the primary decision makers during NIPT counseling (P = 0.06).
  
  
  CONCLUSIONS
  Women electing NIPT tend to have higher scores of depression/anxiety, and those with higher depression scores tended to defer the decision to their husbands.
authors.affiliation: Division of Clinical and Molecular Genetics, Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzumori
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ebara
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kumagai
authors.forename: Shinobu
authors.initials: S
authors.lastname: Goto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamada
authors.forename: Michihiro
authors.initials: M
authors.lastname: Kamijima
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugiura-Ogasawara
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D009035:Mothers / Q000523:psychology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000523:psychology; D011262:Pregnancy Trimester, Second / Q000523:psychology; D011296:Prenatal Diagnosis / Q000523:psychology*; D013315:Stress, Psychological / Q000453:epidemiology*; D011795:Surveys and Questionnaires