title: The design of novel classes of macrolides for neutrophil-dominated inflammatory diseases.
abstract: Neutrophil-dominated inflammatory diseases, like chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, bronchiolitis obliteras syndrome and non-eosinophilic asthma, present a significant medical problem lacking adequate therapy. Macrolide antibiotics have been reported to be effective in the treatment of the aforementioned diseases, for reasons unrelated to their antibacterial action. This has resulted in research activities aimed at gaining a better understanding of the immunomodulatory actions of macrolides and the synthesis of various novel anti-inflammatory macrolides without antimicrobial activity. Despite the difficult chemistry and lack of an extensive knowledge for their mechanism of action, several interesting molecules from this class, including potential clinical candidates, are on the horizon.
authors.affiliation: Fidelta d.o.o., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Eraković Haber
authors.forename: Martina
authors.initials: M
authors.lastname: Bosnar
authors.forename: Goran
authors.initials: G
authors.lastname: Kragol
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D001987:Bronchiectasis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D015195:Drug Design; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D018942:Macrolides