title: Nonsteroidal androgen receptor ligands: versatile syntheses and biological data.
abstract: We report herein a stereoselective and straightforward methodology for the synthesis of new androgen receptor ligands with (anti)-agonistic activities. Oxygen-nitrogen replacement in bicalutamide-like structures paves the way to the disclosure of a new class of analogues, including cyclized/nitrogen-substituted derivatives, with promising antiandrogen (or anabolic) activity.
authors.affiliation: Istituto CNR per la Sintesi Organica e la Fotoreattività (ISOF) , Bologna, Italy.
authors.forename: Greta
authors.initials: G
authors.lastname: Varchi
authors.affiliation: Istituto CNR per la Sintesi Organica e la Fotoreattività (ISOF) , Bologna, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Guerrini
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) , Meldola, Forlì, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Tesei
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) , Meldola, Forlì, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Brigliadori
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna , Bologna, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Bertucci
authors.affiliation: Dipartimento di Patologia Generale II, Università di Napoli , Napoli, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Di Donato
authors.affiliation: Dipartimento di Patologia Generale II, Università di Napoli , Napoli, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Castoria
keywords: androgen receptor; enantiopure antiandrogens; hormone-refractory prostate cancer; sulfinylimino propanamides