title: Multidrug-resistant tuberculosis in the United Kingdom and Lithuania.
abstract: Rates of resistance to first- and second-line drugs in multidrug-resistant tuberculosis (MDR-TB) cases in the United Kingdom were studied during 2010-2012. The highest rates for ethambutol, pyrazinamide and aminoglycosides occurred among patients originating in Eastern Europe, of whom 47% were Lithuanian. Rates of resistance to kanamycin were significantly lower (P < 0.0001) in the Lithuanian National TB Register than among Lithuanian patients resident in the United Kingdom (5% vs. 78%). In 2010, the majority of UK patients of Eastern European origin were located within the London region, whereas in 2011 the majority were located outside this region, a significant change (P = 0.01).
authors.affiliation: National Mycobacterium Reference Laboratory, Barts and the London, Queen Mary's School of Medicine, London, UK.
authors.forename: X
authors.initials: X
authors.lastname: Gonzalo
authors.affiliation: National Mycobacterium Reference Laboratory, Barts and the London, Queen Mary's School of Medicine, London, UK.
authors.forename: D C S
authors.initials: DC
authors.lastname: Hutchison
authors.affiliation: National Mycobacterium Reference Laboratory, Barts and the London, Queen Mary's School of Medicine, London, UK.
authors.forename: F A
authors.initials: FA
authors.lastname: Drobniewski
authors.affiliation: Infectious Diseases and Tuberculosis Hospital, Santariskiu Klinikos, Affiliate of Vilnius University Hospital, Vilnius, Lithuania.
authors.forename: E
authors.initials: E
authors.lastname: Pimkina
authors.affiliation: Infectious Diseases and Tuberculosis Hospital, Santariskiu Klinikos, Affiliate of Vilnius University Hospital, Vilnius, Lithuania.
authors.forename: E
authors.initials: E
authors.lastname: Davidaviciene
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D054242:Emigrants and Immigrants; D004641:Emigration and Immigration; D006801:Humans; D008097:Lithuania / Q000208:ethnology; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology* / Q000382:microbiology; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents