title: Effects of synergistic massage and physical exercise on the expression of angiogenic markers in rat tendons.
abstract: Physical exercise and massage are regarded as key factors in regulating tendon structure. However, information on the mechanism through which massage influences the structure and biology of a tendon is scarce. In this study, we attempted to define the impact of these two activities on rat tendons by using morphological and molecular techniques, determining the expression of VEGF-A, FGF-2, and CD34 in the tendons of rats subjected to 10 weeks of physical exercise (running) with massage of varied duration. The group of rats that was trained and massaged during the entire study was characterized by the highest expression of these markers, compared to the rats subjected to massage before training and to the control group subjected to physical exercises only. The greatest significant differences, compared to the control, were noted in the expression of all the studied markers at mRNA level, and in the case of VEGF-A, at protein level, in the third and fifth weeks of the experiment. The results of this study could point to the synergistic impact of simultaneous massage and physical exercise on the expression of angiogenesis markers in rat tendons.
authors.affiliation: Department of Physiotherapy, University School of Physical Education, 35/p-4 Paderewskiego Street, 51-612 Wroclaw, Poland ; Public Higher Medical Professional School, 68 Katowicka Street, 45-060 Opole, Poland.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Andrzejewski
authors.affiliation: Department of Physiotherapy, University School of Physical Education, 35/p-4 Paderewskiego Street, 51-612 Wroclaw, Poland ; Public Higher Medical Professional School, 68 Katowicka Street, 45-060 Opole, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kassolik
authors.affiliation: Department of Physiotherapy, University School of Physical Education, 35/p-4 Paderewskiego Street, 51-612 Wroclaw, Poland ; Department of Histology and Embryology, Wroclaw Medical University, 6a Chalubinskiego Street, 50-368 Wroclaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
authors.affiliation: Department of Histology and Embryology, Wroclaw Medical University, 6a Chalubinskiego Street, 50-368 Wroclaw, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Pula
authors.affiliation: Department of Histology and Embryology, Wroclaw Medical University, 6a Chalubinskiego Street, 50-368 Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ratajczak-Wielgomas
authors.affiliation: Department of Histology and Embryology, Wroclaw Medical University, 6a Chalubinskiego Street, 50-368 Wroclaw, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Jablonska
authors.affiliation: Public Higher Medical Professional School, 68 Katowicka Street, 45-060 Opole, Poland ; Family Medicine Department, Wroclaw Medical University, 1 Syrokomli Street, 51-141 Wroclaw, Poland.
authors.forename: Donata
authors.initials: D
authors.lastname: Kurpas
authors.affiliation: Public Higher Medical Professional School, 68 Katowicka Street, 45-060 Opole, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Halski
authors.affiliation: Department of Histology and Embryology, Wroclaw Medical University, 6a Chalubinskiego Street, 50-368 Wroclaw, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Podhorska-Okolow
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism; D008405:Massage / Q000379:methods; D018919:Neovascularization, Physiologic / Q000235:genetics* / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013710:Tendons / Q000378:metabolism* / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2