title: Nanobiotechnology promotes noninvasive high-intensity focused ultrasound cancer surgery.
abstract: The successful cancer eradication in a noninvasive manner is the ultimate objective in the fight against cancer. As a "bloodless scalpel," high-intensity focused ultrasound (HIFU) is regarded as one of the most promising and representative noninvasive therapeutic modalities for cancer surgery. However, large-scale clinical applications of HIFU are still in their infancy because of critical efficiency and safety issues which remain to be solved. Fortunately, recently developed nanobiotechnology provides an alternative efficient approach to improve such important issues in HIFU, especially for cancer therapy. This Research News presents the very recent exciting progresses on the elaborate design and fabrication of organic, inorganic, and organic/inorganic hybrid nanoparticles for enhancing the HIFU ablation efficiency against tumor tissues. It is highly expected that this Research News can arouse more extensive research enthusiasm on the development of functional nanomaterials for highly efficient HIFU-based synergistic therapy, which will give a promising noninvasive therapeutic modality for the successful cancer therapy with minimal damage to surrounding normal tissues, due to the noninvasive and site-specific therapeutic features of HIFU.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D001709:Biotechnology; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods* / Q000639:trends; D006801:Humans; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*
keywords: HIFU; cancer; nanobiotechnology; synergistic agent; ultrasound therapy