title: Effect of high dose isoflurane on cerebral blood flow in macaque monkeys.
abstract: The effect of high dose isoflurane on cerebral blood flow (CBF) was investigated in adult macaque monkeys receiving 1% to 2% isoflurane with the pseudo continuous arterial-spin-labeling (pCASL) MRI technique. High concentration (2%) of isoflurane resulted in significant increase in the mean CBF of the global, cortical, subcortical regions and the regional CBF in all subcortical structures and most cortical structures (such as motor cortex, anterior cingulate cortex, but not media prefrontal cortex). In addition, the changes of regional CBF in the affected regions correlated linearly with increasing isoflurane concentrations. The study demonstrates region-specific CBF abnormal increase in adult macaque monkeys under high dose (2%) isoflurane and suggests that the brain functionality in the corresponding structures may be affected and need to be taken consideration in either human or non-human primate neuroimaging studies.
authors.affiliation: Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Li
authors.affiliation: Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Patel
authors.affiliation: Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095.
authors.forename: Danny J J
authors.initials: DJ
authors.lastname: Wang
authors.affiliation: Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329; Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329. Electronic address: xzhang8@emory.edu.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000280:Administration, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007530:Isoflurane / Q000008:administration & dosage*; D008253:Macaca mulatta; D018810:Magnetic Resonance Angiography / Q000379:methods*; D013113:Spin Labels
chemical_list: D018685:Anesthetics, Inhalation; D013113:Spin Labels; D007530:Isoflurane
keywords: Autoregulation; Cerebral blood flow (CBF); Dose-dependent effect; Isoflurane; Non-human primate; Pseudo continuous arterial-spin-labeling (pCASL)