title: Responses to novelty in two inbred strains of mice and their F1 hybrids: Behaviour and brain biogenic amines.
abstract: Responses to novelty of two inbred strains of mice, C57BL/6JOrl (C) and A/JOrl (A) and their reciprocal F1 hybrids were recorded. The parental strains differed from each other: the C strain showed a preference for a novel environment and neophobic reactions to a novel object introduced into the familiar environment. The A mice were characterized by a preference for the familiar environment and lower neophobia towards the novel object. In addition, the C strain exhibited high and the A strain low locomotor activity. The reciprocal hybrids were identical in their major responses to the C strain. Neurochemical investigations indicated that the parental A strain showed a lower level of dopamine in the striatum and in the olfactory bulbs when compared with the C strain and the hybrid F1 C × A.
authors.affiliation: Laboratoire de Psychophysiologie, 7, rue de l'Université, 67000 Strasbourg France.
authors.forename: R
authors.initials: R
authors.lastname: Misslin
authors.affiliation: Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg Cédex France.
authors.forename: E
authors.initials: E
authors.lastname: Kempf
authors.affiliation: Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg Cédex France.
authors.forename: C
authors.initials: C
authors.lastname: Schleef
authors.affiliation: Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg Cédex France.
authors.forename: S
authors.initials: S
authors.lastname: Gobaille
authors.affiliation: Laboratoire de Psychophysiologie, 7, rue de l'Université, 67000 Strasbourg France.
authors.forename: P
authors.initials: P
authors.lastname: Ropartz
authors.affiliation: Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg Cédex France.
authors.forename: P
authors.initials: P
authors.lastname: Mandel