title: The effects of statin use on the development of tuberculosis among patients with diabetes mellitus.
abstract: OBJECTIVE
  To evaluate whether statin use affects the development of tuberculosis (TB) among patients with diabetes mellitus (DM).
  
  
  METHODS
  This is a retrospective cohort study of patients with newly diagnosed type 2 DM based on the South Korean nationwide claims database. The participants were type 2 DM patients aged 20-99 years who were newly treated with anti-diabetic drugs between 1 January 2007 and 31 December 2010. Patients who had statin prescriptions before a diagnosis of diabetes or were diagnosed with TB before diabetes were excluded.
  
  
  RESULTS
  Of 840,899 newly diagnosed type 2 DM patients, 281,842 (33.5%) patients were statin users and 559,057 (66.5%) were non-users. During the study period, 4075 [corrected] individuals were diagnosed with TB; the estimated incidence of TB in our cohort was 251/100,000 patient-years (95%CI 243-258). In comparison to non-TB patients, statin users were less frequent among TB patients (19.2% vs. 33.6%). After adjustment for potential baseline confounders, statin use was not associated with the development of TB in DM patients (aHR 0.98; 95%CI 0.89-1.07).
  
  
  CONCLUSIONS
  TB development among newly diagnosed type 2 DM was considerable, and statin use among these diabetics was not associated with a protective effect on TB incidence.
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Y A
authors.initials: YA
authors.lastname: Kang
authors.affiliation: Medical Research Collaborating Center, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: N-K
authors.initials: NK
authors.lastname: Choi
authors.affiliation: Office of Drug Safety Information II, Korea Institute of Drug Safety & Risk Management, Seoul, Republic of Korea.
authors.forename: J-M
authors.initials: JM
authors.lastname: Seong
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: E Y
authors.initials: EY
authors.lastname: Heo
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
authors.forename: B K
authors.initials: BK
authors.lastname: Koo
authors.affiliation: Department of Social & Preventive Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: S-S
authors.initials: SS
authors.lastname: Hwang
authors.affiliation: Department of Preventive Medicine, Medical Research Collaborating Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: B-J
authors.initials: BJ
authors.lastname: Park
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Yim
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: C-H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D008875:Middle Aged; D065840:Protective Factors; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents