title: A Translocation Renal Cell Carcinoma with Skeletal Muscle Metastasis in a Child.
abstract: Renal cell carcinoma is a tumor that is well known for a high rate of metastasis to several locations like the lung, liver and bones. Skeletal muscle is a rare location for dissemination of the disease. Herein, we describe a 7-year-old boy who presented with flank pain. On physical examination, an abdominal mass located on the left kidney as well as a solid palpable lesion on the left upper arm were detected. Total nephrectomy with subsequent excision of the arm mass was performed. Pathology examination revealed presence of translocation renal cell carcinoma. The patient received α-interferon followed by multikinase inhibitor (Sorafenib) treatment but was lost due to progressive disease. This is the first description of a pediatric patient with skeletal muscle metastases of translocation renal cell carcinoma in the literature.
authors.affiliation: Departments of Pediatric Hematology Oncology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY.
authors.forename: Gülen
authors.initials: G
authors.lastname: Tüysüz
authors.forename: Nihal
authors.initials: N
authors.lastname: Özdemir
authors.forename: Haluk
authors.initials: H
authors.lastname: Emir
authors.forename: Haydar
authors.initials: H
authors.lastname: Durak
authors.forename: Sergülen
authors.initials: S
authors.lastname: Dervişoğlu
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Adaletli
authors.forename: Hilmi
authors.initials: H
authors.lastname: Apak
mesh_terms: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000556:secondary*; D002648:Child; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D015514:Oncogene Proteins, Fusion; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000556:secondary*; D014178:Translocation, Genetic
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D015514:Oncogene Proteins, Fusion; C069203:TFE3 protein, human