title: Observation of correlated X-ray scattering at atomic resolution.
abstract: Tools to study disordered systems with local structural order, such as proteins in solution, remain limited. Such understanding is essential for e.g. rational drug design. Correlated X-ray scattering (CXS) has recently attracted new interest as a way to leverage next-generation light sources to study such disordered matter. The CXS experiment measures angular correlations of the intensity caused by the scattering of X-rays from an ensemble of identical particles, with disordered orientation and position. Averaging over 15 496 snapshot images obtained by exposing a sample of silver nanoparticles in solution to a micro-focused synchrotron radiation beam, we report on experimental efforts to obtain CXS signal from an ensemble in three dimensions. A correlation function was measured at wide angles corresponding to atomic resolution that matches theoretical predictions. These preliminary results suggest that other CXS experiments on disordered ensembles--such as proteins in solution--may be feasible in the future.
authors.affiliation: Department of Applied Physics, Menlo Park, CA 94025, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Mendez
authors.affiliation: Department of Chemistry, Menlo Park, CA 94025, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lane
authors.affiliation: Department of Applied Physics, Menlo Park, CA 94025, USA Department of Biochemistry, Stanford University School of Medicine, Menlo Park, CA 94025, USA.
authors.forename: Jongmin
authors.initials: J
authors.lastname: Sung
authors.affiliation: SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA Department of Physics, AlbaNova University Center, Stockholm University, S-106 91 Stockholm, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Sellberg
authors.affiliation: Department of Geological and Environmental Sciences, Stanford University, Stanford CA 94305, USA Aix-Marseille University, CNRS, IRD, CEREGE UM34, 13545 Aix-en-Provence, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Levard
authors.affiliation: Department of Applied Physics, Menlo Park, CA 94025, USA.
authors.forename: Herschel
authors.initials: H
authors.lastname: Watkins
authors.affiliation: SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
authors.forename: Aina E
authors.initials: AE
authors.lastname: Cohen
authors.affiliation: SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Soltis
authors.affiliation: Department of Biochemistry, Stanford University School of Medicine, Menlo Park, CA 94025, USA.
authors.forename: Shirley
authors.initials: S
authors.lastname: Sutton
authors.affiliation: Department of Biochemistry, Stanford University School of Medicine, Menlo Park, CA 94025, USA.
authors.forename: James
authors.initials: J
authors.lastname: Spudich
authors.affiliation: Department of Chemistry, Menlo Park, CA 94025, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Pande
authors.affiliation: SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ratner
authors.affiliation: Department of Applied Physics, Menlo Park, CA 94025, USA SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA sxdwc@slac.stanford.edu.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Doniach
mesh_terms: D004583:Electrons; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry; D008962:Models, Theoretical; D008968:Molecular Conformation; D012542:Scattering, Radiation; D012834:Silver / Q000737:chemistry; D014961:X-Ray Diffraction / Q000295:instrumentation* / Q000379:methods*
chemical_list: D012834:Silver
keywords: Bragg peak correlations; X-ray angular correlations; atomic resolution X-ray scattering; silver nanoparticles; solution ensemble; synchrotron radiation