title: Toward the design of smart delivery systems controlled by integrated enzyme-based biocomputing ensembles.
abstract: We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based "control unit". The system consists of Janus-type nanoparticles having opposing Au and MS faces, functionalized with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the MS surface and two effectors, glucose oxidase and esterase, immobilized on the Au face. The nanodevice behaves as an enzymatic logical OR operator which is selectively fueled by the presence of D-glucose and ethyl butyrate.
authors.affiliation: Departments of †Analytical Chemistry and ‡Organic Chemistry I, Faculty of Chemistry, Complutense University of Madrid , 28040 Madrid, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Díez
authors.forename: Alfredo
authors.initials: A
authors.lastname: Sánchez
authors.forename: María
authors.initials: M
authors.lastname: Gamella
authors.forename: Paloma
authors.initials: P
authors.lastname: Martínez-Ruíz
authors.forename: Elena
authors.initials: E
authors.lastname: Aznar
authors.forename: Cristina
authors.initials: C
authors.lastname: de la Torre
authors.forename: José R
authors.initials: JR
authors.lastname: Murguía
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Máñez
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Villalonga
authors.forename: José M
authors.initials: JM
authors.lastname: Pingarrón
mesh_terms: D016503:Drug Delivery Systems; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D004950:Esterases / Q000737:chemistry / Q000378:metabolism*; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism*; D006046:Gold / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D004800:Enzymes, Immobilized; D006046:Gold; D012822:Silicon Dioxide; D005949:Glucose Oxidase; D004950:Esterases