title: BMP-functionalised coatings to promote osteogenesis for orthopaedic implants.
abstract: The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.
authors.affiliation: School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. jwang525@gmail.com.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands. j.guo@acta.nl.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. dentliu@aliyun.com.
authors.forename: Jingsong
authors.initials: J
authors.lastname: Liu
authors.affiliation: School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. dentwlm@gmail.com.
authors.forename: Limin
authors.initials: L
authors.lastname: Wei
authors.affiliation: School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. g.wu@acta.nl.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018786:Bone Substitutes / Q000737:chemistry / Q000378:metabolism*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000008:administration & dosage / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D009985:Orthopedics / Q000379:methods; D010012:Osteogenesis; D019736:Prostheses and Implants
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D004247:DNA