title: Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits.
abstract: The concept of Developmental Origins of Health and Disease initially stemmed from the developmental programming of metabolic diseases. Reproductive functions and fertility in adulthood may also be programmed during foetal development. We studied the impact of dietary-induced maternal hyperlipidaemia and hypercholesterolaemia (HH), administered at 10 weeks of age and throughout the gestation and lactation, on male reproductive functions of rabbit offspring. Male rabbits born to HH dams and fed a control diet had significantly lighter testes and epididymes compared with rabbits born to control dams at adulthood. No significant changes in sperm concentration, sperm DNA integrity and sperm membrane composition were observed, but serum-free testosterone concentrations were decreased in HH males. This study confirms the importance of maternal metabolic status for the development of male reproductive organs.
authors.affiliation: 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France.
authors.forename: C
authors.initials: C
authors.lastname: Dupont
authors.affiliation: 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France.
authors.forename: D
authors.initials: D
authors.lastname: Ralliard-Rousseau
authors.affiliation: 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France.
authors.forename: A
authors.initials: A
authors.lastname: Tarrade
authors.affiliation: 3 APHP, Hosp Jean-Verdier, Bondy, France.
authors.forename: C
authors.initials: C
authors.lastname: Faure
authors.affiliation: 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France.
authors.forename: M
authors.initials: M
authors.lastname: Dahirel
authors.affiliation: 6 Clermont Université, Université d'Auvergne, Pharmacologie Fondamentale et Clinique de la Douleur, Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Sion
authors.affiliation: 8 CHU Clermont Ferrand, CHU Estaing, Assistance Médicale à la Procréation, CECOS, Place Aubrac, Clermont Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Brugnon
authors.affiliation: 3 APHP, Hosp Jean-Verdier, Bondy, France.
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.affiliation: 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France.
authors.forename: P
authors.initials: P
authors.lastname: Chavatte-Palmer
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects; D005260:Female; D005837:Genitalia, Male / Q000254:growth & development / Q000378:metabolism*; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D008297:Male; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena / Q000502:physiology*; D011817:Rabbits; D011897:Random Allocation; D012098:Reproduction / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
chemical_list: D004041:Dietary Fats; D013739:Testosterone