title: Resveratrol and calcium signaling: molecular mechanisms and clinical relevance.
abstract: Resveratrol is a naturally occurring compound contributing to cellular defense mechanisms in plants. Its use as a nutritional component and/or supplement in a number of diseases, disorders, and syndromes such as chronic diseases of the central nervous system, cancer, inflammatory diseases, diabetes, and cardiovascular diseases has prompted great interest in the underlying molecular mechanisms of action. The present review focuses on resveratrol, specifically its isomer trans-resveratrol, and its effects on intracellular calcium signaling mechanisms. As resveratrol's mechanisms of action are likely pleiotropic, its effects and interactions with key signaling proteins controlling cellular calcium homeostasis are reviewed and discussed. The clinical relevance of resveratrol's actions on excitable cells, transformed or cancer cells, immune cells and retinal pigment epithelial cells are contrasted with a review of the molecular mechanisms affecting calcium signaling proteins on the plasma membrane, cytoplasm, endoplasmic reticulum, and mitochondria. The present review emphasizes the correlation between molecular mechanisms of action that have recently been identified for resveratrol and their clinical implications.
authors.affiliation: Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA. aemqp4@mail.umkc.edu.
authors.forename: Audrey E
authors.initials: AE
authors.lastname: McCalley
authors.affiliation: Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA. kajas@umkc.edu.
authors.forename: Simon
authors.initials: S
authors.lastname: Kaja
authors.affiliation: Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA. paynea@umkc.edu.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Payne
authors.affiliation: Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA. koulenp@umkc.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Koulen
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects*; D006801:Humans; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D013267:Stilbenes; D000077185:Resveratrol