title: Innervation pattern of polycystic ovaries in the women.
abstract: The aim of the present study was to determine the changes in both the distribution pattern and density of nerve fibers containing dopamine β-hydroxylase (DβH), vesicular acetylcholine transporter (VAChT), neuronal nitric oxide synthase (nNOS), substance P (SP), calcitonin gene related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), somatostatin (SOM), galanin (GAL) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the human polycystic ovaries. In the polycystic ovaries, when compared to the immunoreactions pattern observed in the control gonads, following changes were revealed: (1) an increase in the number of DβH-, VAChT-, VIP- or GAL-immunoreactive (IR) nerve fibers within the stroma as well as in the number of DβH-IR fibers near primordial follicles and medullar veins and venules; (2) a reduction in the number of nerve fibers containing nNOS, CGRP, SOM, PACAP within the stroma and in the numbers of CGRP-IR fibers around arteries; (3) an appearance of SP- and GAL-IR fibers around medullar and cortical arteries, arterioles, veins and venules, with except of GAL-IR fibers supplying medullar veins; and (4) the lack of nNOS-IR nerve fibers near primordial follicles and VIP-IR nerves around medullar arteries and arterioles. In conclusion, our results suggest that the changes in the innervation pattern of the polycystic ovaries in human may play an important role in the pathogenesis and/or course of this disorder.
authors.affiliation: Department of Pathophysiology, Laboratory for Regenerative Medicine, Stem Cell Research Laboratory, Department of Neurology and Neurosurgery University of Warmia and Mazury, Olsztyn, Poland. Electronic address: joanna.wojtkiewicz@uwm.edu.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Wojtkiewicz
authors.affiliation: Division of Reproductive Biology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Jana
authors.affiliation: Department of Human Physiology, Faculty of Medicine Sciences, University of Warmia and Mazury, Olsztyn, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kozłowska
authors.affiliation: Department and Clinic of Urology, Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Crayton
authors.affiliation: Department of Human Physiology, Faculty of Medicine Sciences, University of Warmia and Mazury, Olsztyn, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Majewski
authors.affiliation: Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Zalecki
authors.affiliation: Department of General and Oncological Gynecology, Military Medical Institute, Warsaw, Poland.
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Baranowski
authors.affiliation: Department and Clinic of Urology, Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Radziszewski
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009412:Nerve Fibers / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D010053:Ovary / Q000294:innervation*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism / Q000473:pathology*
chemical_list: D018377:Neurotransmitter Agents
keywords: Innervation pattern; Nerve fibers; Polycystic ovary syndrome; Women