title: Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis.
abstract: An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow , Joseph Black Building, University Avenue, Glasgow G12 8QQ, U.K.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Letort
authors.forename: Rémi
authors.initials: R
authors.lastname: Aouzal
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.forename: De-Liang
authors.initials: DL
authors.lastname: Long
authors.forename: Joëlle
authors.initials: J
authors.lastname: Prunet
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D017239:Paclitaxel / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel