title: The use of antidepressant medication in Parkinson's disease patients is not affected by the type of antiparkinson medication.
abstract: Previous studies have suggested that dopamine agonists have an antidepressant effect in Parkinson's disease (PD) patients. We examined whether fewer PD patients used antidepressant medication, when they were first treated with a dopamine agonist compared to other PD medications. PD patients diagnosed in Denmark were identified, and the diagnosis was confirmed by a review of the medical record. Antidepressant medication was assessed using the Danish National Prescription Registry. We used Cox proportional hazards regression to model the association between PD medications and time to antidepressant prescription. The type of PD medication first prescribed did not affect the subsequent use of antidepressants.
authors.affiliation: Department of Neurology, Odense University Hospital & Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Krøigård
authors.affiliation: Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark.
authors.forename: Jane
authors.initials: J
authors.lastname: Christensen
authors.affiliation: Department of Neurology, Odense University Hospital & Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Wermuth
authors.affiliation: Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA.
authors.forename: Beate
authors.initials: B
authors.lastname: Ritz
authors.affiliation: Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark.
authors.forename: Christina Funch
authors.initials: CF
authors.lastname: Lassen
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D003863:Depression / Q000150:complications* / Q000188:drug therapy*; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D016016:Proportional Hazards Models; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000978:Antiparkinson Agents; D018491:Dopamine Agonists
keywords: Antidepressant medication; MAO-B inhibitors; Parkinson's disease; depression; dopamine agonists; levodopa