title: Diagnostic value of analysis of H-FABP, NT-proBNP, and cTnI in heart function in children with congenital heart disease and pneumonia.
abstract: OBJECTIVE
  To analyze the expression of heart-fatty acid-binding protein (H-FABP), N-terminal pro-brain natriuretic peptide (NT-proBNP), and cTnI in children with congenital heart disease (CHD) and pneumonia, and evaluate its diagnostic value in heart failure (HF).
  
  
  METHODS
  The levels of serum H-FABP, NT-proBNP, and cardiac troponin 1 (cTnI) were measured by immunoassays in 22 children with CHD, pneumonia, and HF (group I), 25 children with CHD and pneumonia (group II), and 25 healthy children without CHD or pneumonia (control group).
  
  
  RESULTS
  The concentration and positive rate of serum H-FABP, NT-proBNP, and cTnI were significantly higher in group I than those in group II. Compared to control group, these indexes were increased in both group I and group II. There were statistical significant differences in the positive rate of NT-proBNP and cTnI but not H-FABP between groups of patients with different classes of heart function.
  
  
  CONCLUSIONS
  The levels of H-FABP, NT-proBNP, and cTnI were correlated with heart function, and can be used for the diagnosis of early-stage HF in children with CHD.
authors.affiliation: The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China. jianweijiacn@163.com.
authors.forename: F-J
authors.initials: FJ
authors.lastname: Zhou
authors.forename: C-Y
authors.initials: CY
authors.lastname: Zhou
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Tian
authors.forename: A-J
authors.initials: AJ
authors.lastname: Xiao
authors.forename: P-L
authors.initials: PL
authors.lastname: Li
authors.forename: Y-H
authors.initials: YH
authors.lastname: Wang
authors.forename: J-W
authors.initials: JW
authors.lastname: Jia
mesh_terms: D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006321:Heart / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011014:Pneumonia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain