title: Markers of endothelial dysfunction and inflammation predict progression of diabetic nephropathy in African Americans with type 1 diabetes.
abstract: African Americans with early-onset type 1 diabetes mellitus are at a high risk for severe diabetic nephropathy and end-stage renal disease. In order to determine whether baseline plasma levels of inflammatory markers predict incidence of overt proteinuria or renal failure in African Americans with type 1 diabetes mellitus, we re-examined data of 356 participants in our observational follow-up study of 725 New Jersey African Americans with type 1 diabetes. At baseline and 6-year follow-up, a detailed structured clinical interview was conducted to document medical history including kidney dialysis or transplant, other diabetic complications, and renal-specific mortality. Plasma levels of 28 inflammatory biomarkers were measured using a multiplex bead analysis system. After adjusting for baseline age, glycohemoglobin, and other confounders, the baseline plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) in the upper two quartiles were, respectively, associated with a three- to fivefold increase in the risk of progression from no albuminuria or microalbuminuria to overt proteinuria. Baseline plasma levels of the chemokine eotaxin in the upper quartile were significantly associated with a sevenfold increase in risk of incident renal failure. These associations were independent of traditional risk factors for progression of diabetic nephropathy. Thus, in type 1 diabetic African Americans, sICAM-1 predicted progression to overt proteinuria and eotaxin-predicted progression to renal failure.
authors.affiliation: Institute of Ophthalmology and Visual Science, UMDNJ, Rutgers University, Newark, New Jersey, USA.
authors.forename: Monique S
authors.initials: MS
authors.lastname: Roy
authors.affiliation: Department of Epidemiology and Health Promotion, NYU College of Dentistry, New York, New York, USA.
authors.forename: Malvin N
authors.initials: MN
authors.lastname: Janal
authors.affiliation: Department of Pathology and Laboratory Medicine and NJMS Molecular Resource Facility, Rutgers University, Newark, New Jersey, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Crosby
authors.affiliation: Department of Pathology and Laboratory Medicine and NJMS Molecular Resource Facility, Rutgers University, Newark, New Jersey, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Donnelly
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1