title: A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases.
abstract: (E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aβ and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aβ self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test).
authors.affiliation: Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
authors.forename: Matteo
authors.initials: M
authors.lastname: Staderini
authors.affiliation: SISSA, Neuroscience Department, Via Bonomea 265, 34136 Trieste, Italy.
authors.forename: Suzana
authors.initials: S
authors.lastname: Aulić
authors.affiliation: Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Bartolini
authors.affiliation: SISSA, Neuroscience Department, Via Bonomea 265, 34136 Trieste, Italy.
authors.forename: Hoang Ngoc Ai
authors.initials: HN
authors.lastname: Tran
authors.affiliation: Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: González-Ruiz
authors.affiliation: Instituto de Química Médica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Pérez
authors.affiliation: Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Cabezas
authors.affiliation: Instituto de Química Médica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Martínez
authors.affiliation: Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
authors.forename: M Antonia
authors.initials: MA
authors.lastname: Martín
authors.affiliation: Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Andrisano
authors.affiliation: SISSA, Neuroscience Department, Via Bonomea 265, 34136 Trieste, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Legname
authors.affiliation: Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Menéndez
authors.affiliation: Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Bolognesi
keywords: Aggregation; amyloid; fibrillation inhibitors; protein misfolding diseases