title: Combined action of C-reactive protein and lipid profiles on risk of hypertension and prehypertension in Mongolian adults in Inner Mongolia, China.
abstract: BACKGROUND
  Many studies have suggested that C-reactive protein (CRP) and blood lipids are associated with hypertension and cardiovascular disease (CVD). However, few studies discussed the combined action of CRP and blood lipids on the risk of hypertension and prehypertension. This study aimed to investigate the combined action of CRP and lipid profiles on the risk of hypertension and prehypertension in Mongolian adults from Inner Mongolia, China.
  
  
  METHODS
  The systolic and diastolic blood pressure, height, weight and waist circumference were measured and factors such as smoking, alcohol intake, family history of hypertension, etc., were investigated and CRP, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) were tested for 2 534 Mongolian adults aged ≥ 20 years. The subjects were divided into four subgroups, namely CRP <median and LDL-C (TG) <median subgroup, CRP <median and LDL-C (TG) >median subgroup, CRP >median and LDL-C (TG) <median subgroup and CRP >median and LDL-C (TG) >median subgroup. The ORs (95% CIs) of hypertension and prehypertension for the subgroups were calculated by univariate and multivariate analysis.
  
  
  RESULTS
  The multivariate adjusted ORs (95%CIs) of hypertension/prehypertension were 1.389 (0.979-1.970)/1.151(0.865-1.531), 1.666 (1.159-2.394)/1.431 (1.060-1.930), 1.756 (1.242-2.484)/ 1.770 (1.321-2.372), for CRP <median and LDL-C >median subgroup, CRP >median and LDL-C <median subgroup, and CRP >median and LDL-C >median subgroup, respectively, compared with CRP <median and LDL-C <median subgroup. Similarly, the multivariate adjusted ORs (95% CIs) of hypertension/prehypertension were 2.032 (1.394-2.963)/1.442 (1.047-1.988), 1.412 (0.960-2.079)/1.596 (1.166-2.184), and 2.197 (1.595-3.027)/1.730 (1.321-2.266) for CRP <median and TG >median subgroup, CRP >median and TG <median subgroup, and CRP >median and TG >median subgroup, respectively, compared with CRP <median and TG <median subgroup. The risks of hypertension and prehypertension were the highest in the CRP >median and LDL-C (TG) >median subgroup among the four subgroups.
  
  
  CONCLUSIONS
  Subjects with both CRP >median and LDL-C (TG) >median had highest risks of hypertension and prehypertension among all subjects. This study appeared to indicate that the combined action of elevated CRP and elevated LDL-C (TG) further increase the risks of hypertension and prehypertension among Mongolian population.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China; Department of Food Sanitation, Suzhou Food and Drug Administration, Suzhou, Jiangsu 215007, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan, Hebei 063000, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
authors.forename: Aili
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China; Department of Health Care, Xiamen Maternal and Child Care Hospital, Xiamen, Fujian 361003, China.
authors.forename: Guiyan
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan, Hebei 063000, China.
authors.forename: Dali
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China. Email: yhzhang@suda.edu.cn.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055105:Waist Circumference / Q000502:physiology
chemical_list: D008055:Lipids; D002097:C-Reactive Protein