title: Triglyceride-lowering agents.
abstract: This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered. Unfortunately, to date, harmless and effective triglyceride-lowering drug still does not exist and there is still need for development of better triglyceride-lowering agents.
authors.affiliation: Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russian Federation.
authors.forename: Nariman F
authors.initials: NF
authors.lastname: Salakhutdinov
authors.affiliation: Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation. Electronic address: sergey@nioch.nsc.ru.
authors.forename: Sergey S
authors.initials: SS
authors.lastname: Laev
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists*; D014280:Triglycerides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D047492:Peroxisome Proliferator-Activated Receptors; D014280:Triglycerides; D002784:Cholesterol
keywords: Fibrates; Nicotinic acid; Omega-3 fatty acids; PPARα and PPARα/γ agonists; Squalene synthase inhibitors; Statins; Triglyceride-lowering agents