title: Posaconazole concentrations in human tissues after allogeneic stem cell transplantation.
abstract: Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.
authors.affiliation: Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden ola.blennow@karolinska.se.
authors.forename: Ola
authors.initials: O
authors.lastname: Blennow
authors.affiliation: Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Eliasson
authors.affiliation: Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Tommy
authors.initials: T
authors.lastname: Pettersson
authors.affiliation: Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Anton
authors.initials: A
authors.lastname: Pohanka
authors.affiliation: Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Attila
authors.initials: A
authors.lastname: Szakos
authors.affiliation: Experimental Cancer Medicine, Clinical Research Centre, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: El-Serafi
authors.affiliation: Experimental Cancer Medicine, Clinical Research Centre, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Hassan
authors.affiliation: Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Ringdén
authors.affiliation: Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Mattsson
mesh_terms: D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001344:Autopsy; D001923:Brain Chemistry; D006086:Graft vs Host Disease / Q000209:etiology / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D009181:Mycoses / Q000517:prevention & control; D009206:Myocardium / Q000737:chemistry; D014184:Transplantation, Homologous; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole