title: The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?
abstract: The treatment of Alzheimer's disease (AD) still remains an area of significant unmet need, with drugs that only target the symptoms of the disease. Therefore, there is considerable need for disease-modifying therapies. The complex etiology of AD prompts scientists to develop multitarget strategies to combat causes and symptoms. To this aim, we designed, synthesized, and tested four new carbamates as dual cholinesterase-FAAH inhibitors. The dual activity of these compounds could lead to a potentially more effective treatment for the counteraction of AD progression, because they would allow regulation of both ACh and eCB signaling and improve neuronal transmission and/or counteract neuroinflammation.
authors.affiliation: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rampa
authors.affiliation: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Bartolini
authors.affiliation: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bisi
authors.affiliation: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Belluti
authors.affiliation: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gobbi
authors.affiliation: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Andrisano
authors.affiliation: Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council , Via Campi Flegrei 34 Comprensorio Olivetti, 80078 Pozzuoli, NA, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Ligresti
authors.affiliation: Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council , Via Campi Flegrei 34 Comprensorio Olivetti, 80078 Pozzuoli, NA, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
keywords: AChE; Alzheimer's disease; BuChE; FAAH; carbamate inhibitors; drug design