title: Resveratrol in vitro ameliorates tert-butyl hydroperoxide-induced alterations in erythrocyte membranes from young and older humans.
abstract: Implication of reactive oxygen species/oxidative stress has been readily reported in etiology of aging and related manifestations. Plasma membrane as a regulator of numerous aspects of cell physiology including cell-cell interaction, solute transport, and signal transduction, provides structural integrity to the cells. The aim of the present study was to determine the effect of resveratrol administration in vitro, to evaluate the biological effect of this phytoalexin in oxidatively injured erythrocytes during aging. This study, carried out on 91 normal healthy subjects, provides experimental evidence that erythrocytes have increased oxidative damage with age. In vitro administration of resveratrol significantly attenuated deleterious effects of oxidative injury in erythrocytes from humans of all ages.
authors.affiliation: Department of Biochemistry, University of Allahabad, Allahabad 211002.
authors.forename: Kanti Bhooshan
authors.initials: KB
authors.lastname: Pandey
authors.forename: Syed Ibrahim
authors.initials: SI
authors.lastname: Rizvi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D055815:Young Adult; D020122:tert-Butylhydroperoxide / Q000009:adverse effects
chemical_list: D013267:Stilbenes; D020122:tert-Butylhydroperoxide; D000077185:Resveratrol
keywords: aging; erythrocytes; osmotic stability; oxidative stress; resveratrol; resvératrol; stabilité osmotique; stress oxydatif; vieillissement; érythrocytes