title: Spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia: clinical and computed tomographic features in 8 cases.
abstract: OBJECTIVE
  The aim of this study was to evaluate the patient demographic and computed tomography (CT) imaging findings of spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia.
  
  
  METHODS
  Ten cases of spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia diagnosed during 1993-2013 were reviewed. Eight cases with CT images were reviewed.
  
  
  RESULTS
  The mean age of diagnosis of osteosarcoma was 37.8 years (range, 8-55 years). The presence of a soft tissue extension component beyond the area of cortical bone destruction was demonstrated radiographically in 7 out of 8 cases. Mineralization of tumor matrix was seen in 6 cases. Periosteal reaction was demonstrated in only 1 case; 1 out of 6 cases showed significant enhancement on postcontrast CT images. Nine patients had surgical resections of tumor. Seven of them died of tumor, with a mean survival time of 5.3 years.
  
  
  CONCLUSIONS
  This study provides CT imaging features with clinical information of spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia.
authors.affiliation: Shanghai East Hospital, Shanghai, China.
authors.forename: Tao-Tao
authors.initials: TT
authors.lastname: Sun
authors.affiliation: Department of Radiology, Shanghai Ninth People's Hospital, Shanghai, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Tao
authors.affiliation: Department of Radiology, Shanghai Ninth People's Hospital, Shanghai, China. Electronic address: shihuimin9h@163.com.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003287:Contrast Media; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012042:Registries; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide