title: Insights into pediatric herpes simplex encephalitis from a cohort of 21 children from the California Encephalitis Project, 1998-2011.
abstract: Twenty-one children with confirmed herpes simplex encephalitis were identified in the California Encephalitis Project.Noteworthy features included 6 (29%) patients with an initial negative herpes simplex virus cerebrospinal fluid polymerase chain reaction test and 13 (62%) patients with extratemporal lobe involvement identified by neuroimaging [corrected]. Eleven cases were <4 years of age, but all 4 fatal cases occurred in adolescents.
authors.affiliation: From the *Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco; †Communicable Disease and Emergency Response Branch, Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond; ‡California Epidemiologic Investigation Service (Cal-EIS), California Department of Public Health, Sacramento, CA; §National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD; ¶Viral and Rickettsial Disease Laboratory, Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, CA; and ‖Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Division of Viral Diseases, Office of Infectious Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
authors.forename: Tu M
authors.initials: TM
authors.lastname: To
authors.forename: Ariane
authors.initials: A
authors.lastname: Soldatos
authors.forename: Heather
authors.initials: H
authors.lastname: Sheriff
authors.forename: D Scott
authors.initials: DS
authors.lastname: Schmid
authors.forename: Natasha
authors.initials: N
authors.lastname: Espinosa
authors.forename: Giorgio
authors.initials: G
authors.lastname: Cosentino
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Preas
authors.forename: Carol A
authors.initials: CA
authors.lastname: Glaser
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002140:California; D002555:Cerebrospinal Fluid / Q000821:virology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D020803:Encephalitis, Herpes Simplex / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D059906:Neuroimaging; D016133:Polymerase Chain Reaction; D016019:Survival Analysis