title: Low infectivity of a novel avian-origin H7N9 influenza virus in pigs.
abstract: We studied the pathogenesis and transmissibility of a novel avian-origin H7N9 influenza virus in pigs. When pigs were infected with H7N9 influenza virus, they did not show any clear clinical signs (such as sneezing, fever and loss of body weight), and they shed viruses through their noses for 2 days after infection. No transmission occurred between infected and naïve pigs. Pigs suffered from mild pneumonia, which was accompanied by the induction of inflammatory cytokines and chemokines such as IL-8 and CCL1. Taken together, our results suggest that pigs may not play an active role in transmitting H7N9 influenza virus to mammals.
authors.affiliation: Laboratory of Influenza Research, College of Veterinary Medicine, Institute for Influenza Virus, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305-764, Republic of Korea.
authors.forename: Jung
authors.initials: J
authors.lastname: Yum
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Park
authors.forename: Keun Bon
authors.initials: KB
authors.lastname: Ku
authors.forename: Ji An
authors.initials: JA
authors.lastname: Kim
authors.forename: Seung Kyoo
authors.initials: SK
authors.lastname: Oh
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Heui
authors.initials: SH
authors.lastname: Seo
mesh_terms: D000818:Animals; D054402:Chemokine CCL1 / Q000378:metabolism; D004195:Disease Models, Animal; D064766:Influenza A Virus, H7N9 Subtype / Q000235:genetics / Q000472:pathogenicity*; D016209:Interleukin-8 / Q000378:metabolism; D008168:Lung / Q000473:pathology / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000635:transmission* / Q000662:veterinary / Q000821:virology; D011014:Pneumonia / Q000662:veterinary / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D013552:Swine / Q000821:virology; D019562:Viral Load; D017201:Virus Shedding
chemical_list: D054402:Chemokine CCL1; D016209:Interleukin-8; D012367:RNA, Viral