title: Efficacy of colestilan in the treatment of hyperphosphataemia in renal disease patients.
abstract: BACKGROUND
  Hyperphosphataemia is common in chronic kidney disease (CKD), particularly in the late stages and is associated with secondary hyperparathyroidism, abnormal bone mineralisation and increased cardiovascular morbidity/mortality. At present, there is a range of phosphate binders designed to keep serum phosphate at normal or near normal levels. Colestilan is a new binder that offers additional actions that may afford further benefits over simply lowering phosphate.
  
  
  METHODS
  This paper reviews the pharmacology and clinical data currently available in the use of colestilan to treat hyperphosphataemia in CKD stage 5 patients on dialysis.
  
  
  CONCLUSIONS
  Available phosphate binders lower serum phosphorus levels to a clinically relevant extent. The balance between the risks and the potential benefits associated with each agent must be considered when choosing a binder. Calcium-based binders can lead to hypercalcaemia and/or positive calcium balance and cardiovascular calcification. Like sevelamer, colestilan is not absorbed and there is no evidence of any risk of hypercalcaemia. In addition, a significant lowering of low-density lipoprotein-cholesterol, similar to simvastatin, a reduction in plasma uric acid and a reduction in high glycosylated haemoglobin values suggest additional beneficial actions that may convert to reductions in mortality.
authors.affiliation: Alessandro Manzoni Hospital, Department of Nephrology Dialysis and Renal Transplantation , Via Dell'Eremo 9, Lecco, 23900 , Italy +39 0341 489850 ; +39 0341 489860 ; f.locatelli@ospedale.lecco.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Nada
authors.initials: N
authors.lastname: Dimkovic
authors.forename: Goce
authors.initials: G
authors.lastname: Spasovski
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy / Q000209:etiology; D054559:Hyperphosphatemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy
chemical_list: D001647:Bile Acids and Salts; D010710:Phosphates; D002118:Calcium; C106574:cholebine
keywords: chronic kidney disease; colestilan; dialysis; hyperphosphataemia; phosphate binder; tolerability