title: The role of magnetic resonance diffusion-weighted imaging and three-dimensional arterial spin labelling perfusion imaging in the differentiation of parasellar meningioma and cavernous haemangioma.
abstract: OBJECTIVE
  To evaluate the diagnostic value of magnetic resonance diffusion-weighted imaging (DWI) and three-dimensional arterial spin labelling perfusion imaging (3D-ASL) in distinguishing cavernous haemangioma from parasellar meningioma, using histological data as a reference standard.
  
  
  METHODS
  Patients with parasellar meningioma or parasellar cavernous haemangioma underwent conventional T1- and T2-weighted magnetic resonance imaging (MRI) followed by DWI and 3D-ASL using a 3.0 Tesla MRI. The minimum apparent diffusion coefficient (minADC) from DWI and the maximal normalized cerebral blood flow (nCBF) from 3D-ASL were measured in each tumour. Diagnosis was confirmed by histology.
  
  
  RESULTS
  MinADC was significantly lower and nCBF significantly higher in meningioma (n = 19) than cavernous haemangioma (n = 15). There was a significant negative correlation between minADC and nCBF (r = -0.605).
  
  
  CONCLUSIONS
  DWI and 3D-ASL are useful in differentiating cavernous haemangiomas from parasellar meningiomas, particularly in situations when the appearance on conventional MRI sequences is otherwise ambiguous.
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Xiao
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lou
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Meng-Yu
authors.initials: MY
authors.lastname: Liu
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Zhi-Ye
authors.initials: ZY
authors.lastname: Chen
authors.affiliation: General Electric Company GE (China) Co., Ltd, Healthcare, Beijing, China.
authors.forename: Kai-Ning
authors.initials: KN
authors.lastname: Shi
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China cjr.malin@vip.163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005260:Female; D006392:Hemangioma, Cavernous / Q000145:classification / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013113:Spin Labels; D055815:Young Adult
chemical_list: D013113:Spin Labels
keywords: Diffusion-weighted imaging; cavernous haemangioma; meningioma; parasellar; three-dimensional arterial spin labelling