title: Reciprocal interaction between the suprachiasmatic nucleus and the immune system tunes down the inflammatory response to lipopolysaccharide.
abstract: Several studies have shown circadian variations in the response of the immune system suggesting a role of the suprachiasmatic nucleus (SCN). Here we show that lipopolysaccharide (LPS) administration in the beginning of the active period induced more severe responses in temperature and cytokines than LPS given in the rest period. Moreover night administered LPS increased SCN basal neuronal activity indicating a direct influence of inflammation on the SCN. Bilateral lesions of the SCN resulted in an increased inflammatory response to LPS demonstrating that an interaction between the SCN and the immune system modulates the intensity of the inflammatory response.
authors.affiliation: Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
authors.forename: Natalí N
authors.initials: NN
authors.lastname: Guerrero-Vargas
authors.affiliation: Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, Zona Universitaria c.p, 78290 San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: Salgado-Delgado
authors.affiliation: Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Basualdo
authors.affiliation: Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
authors.forename: Joselyn
authors.initials: J
authors.lastname: García
authors.affiliation: Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
authors.forename: Mara
authors.initials: M
authors.lastname: Guzmán-Ruiz
authors.affiliation: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
authors.forename: Julio C
authors.initials: JC
authors.lastname: Carrero
authors.affiliation: Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
authors.forename: Carolina
authors.initials: C
authors.lastname: Escobar
authors.affiliation: Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, Mexico. Electronic address: ruudbuijs@gmail.com.
authors.forename: Ruud M
authors.initials: RM
authors.lastname: Buijs
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002452:Cell Count; D002940:Circadian Rhythm / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007107:Immune System / Q000187:drug effects*; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D008070:Lipopolysaccharides; D016760:Proto-Oncogene Proteins c-fos
keywords: Circadian rhythms; Cytokines; LPS; Temperature response; Wistar rats