title: [Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia].
abstract: OBJECTIVE
  To explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.
  
  
  METHODS
  Using MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.
  
  
  RESULTS
  The ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).
  
  
  CONCLUSIONS
  The ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.
authors.forename: Chun-Lian
authors.initials: CL
authors.lastname: Liu
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Jiao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.forename: Shao-Tong
authors.initials: ST
authors.lastname: Jia
authors.forename: Wan-hong
authors.initials: WH
authors.lastname: Jing
authors.forename: Qing-Hu
authors.initials: QH
authors.lastname: Yang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D004260:DNA Repair; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human