title: A Strategy for Suppressing Redox Stress within Mitochondria.
abstract: An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.
authors.affiliation: Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , 1001 South McAllister Avenue, Tempe, Arizona 85287, United States.
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Arce
authors.affiliation: Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , 1001 South McAllister Avenue, Tempe, Arizona 85287, United States.
authors.forename: Omar M
authors.initials: OM
authors.lastname: Khdour
authors.affiliation: Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , 1001 South McAllister Avenue, Tempe, Arizona 85287, United States.
authors.forename: Ruth
authors.initials: R
authors.lastname: Goldschmidt
authors.affiliation: Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , 1001 South McAllister Avenue, Tempe, Arizona 85287, United States.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Armstrong
authors.affiliation: Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , 1001 South McAllister Avenue, Tempe, Arizona 85287, United States.
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Hecht
keywords: Reactive oxygen species; electron transport chain; lipid peroxidation; mitochondria