title: MicroRNA as potential biomarker in HCV-associated diffuse large B-cell lymphoma.
abstract: OBJECTIVE
  To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling.
  
  
  METHODS
  In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed according to HCV presence. Germinal centres, from reactive lymph nodes were used as controls. Clinical features at presentation were available for all patients.
  
  
  RESULTS
  A set of 52 miRNAs define a signature for HCV-associated DLBCL. Importantly, decreased expression of miR-138-5p and increased expression of miR-147a, miR-147b and miR-511-5p in HCV DLBCL was found to be a poor prognostic factor for HCV-positive DLBCL patients.
  
  
  CONCLUSIONS
  These data reveal molecular differences in diffuse DLBCL patients according to HCV presence, potentially useful as novel prognostic or therapeutic biomarkers.
authors.affiliation: Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Augello
authors.affiliation: Hematopathology Section, Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Gianelli
authors.affiliation: Division of Pathology, San Paolo Hospital, Milan, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Savi
authors.affiliation: Division of Pathology, San Paolo Hospital, Milan, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Moro
authors.affiliation: Division of Pathology, A.Manzoni Hospital, Lecco, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Bonoldi
authors.affiliation: Department of Laboratory Medicine, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Gambacorta
authors.affiliation: Division of Pathology, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Vaira
authors.affiliation: Division of Hematology, Department of Clinical and Community Sciences, University of Milan, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Baldini
authors.affiliation: Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Bosari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D016174:Hepacivirus; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology / Q000821:virology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: HEPATITIS; LYMPHOMA; VIRUS