title: Poly(ADP-ribose): an organizer of cellular architecture.
abstract: Distinct properties of poly(ADP-ribose)-including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature-could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADP-ribose) could direct cellular organization.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 anleung@jhsph.edu.
authors.forename: Anthony K L
authors.initials: AK
authors.lastname: Leung
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D004330:Drosophila; D006801:Humans; D008938:Mitosis; D011064:Poly Adenosine Diphosphate Ribose / Q000502:physiology*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011485:Protein Binding; D008941:Spindle Apparatus
chemical_list: D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases