title: Advances in preimplantation genetic diagnosis/screening.
abstract: Preimplantation genetic diagnosis (PGD) gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection. Preimplantation genetic screening (PGS) is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage. However, how and to whom PGS should be provided is a controversial topic. The first successful case of PGD of a human being was reported in 1990, and there have been tremendous improvements in this technology since then. Both embryo biopsy and genetic technologies have been improved dramatically, which increase the accuracy and expand the indications of PGD/PGS.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
authors.forename: LiYing
authors.initials: L
authors.lastname: Yan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: XiaoHui
authors.initials: X
authors.lastname: Zhu
authors.forename: XiaoDan
authors.initials: X
authors.lastname: Shi
authors.forename: Xi
authors.initials: X
authors.lastname: Xia
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.forename: CuiLing
authors.initials: C
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Lian
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
mesh_terms: D001755:Blastocyst / Q000378:metabolism* / Q000473:pathology; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000235:genetics; D055028:Comparative Genomic Hybridization; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods* / Q000639:trends; D011296:Prenatal Diagnosis / Q000379:methods* / Q000639:trends