title: Associations between serum hepcidin level, FGF-21 level and oxidative stress with arterial stiffness in CAPD patients.
abstract: BACKGROUND
  Patients on continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. Atherosclerosis is associated with increased arterial stiffness (AS), endothelial dysfunction and elevated oxidative stress (OS) and inflammation. We aimed to investigate the relationship between oxidative stress status, arterial stiffness, hepcidin and fibroblast growth factor-21 (FGF-21) levels in CAPD patients.
  
  
  METHODS
  As a prospective observational study, we analyzed 56 CAPD patients, aged between 30 and 63 years. Serum hepcidin, FGF-21 levels, OS status and AS were determined. Arterial stiffness was measured by flow-mediated dilatation (FMD). Oxidative stress status was determined by total antioxidant status, total oxidant status (TOS) and oxidative stress index (OSI).
  
  
  RESULTS
  FMD was negatively correlated with TOS, OSI, hepcidin and FGF-21 (r: -0.313, p: 0.020; r: -0.0331, p: 0.014; r: -0.498, p < 0.001; r: -0.403, p: 0.002, respectively). OSI was positively correlated with hepcidin, parathormone and negatively correlated with FMD (r: 0.278, p: 0.040; r: 0.462, p < 0.001; r: -0.0331, p: 0.014, respectively).
  
  
  CONCLUSIONS
  There are many factors affecting arterial stiffness in CAPD patients. In our study, higher levels of OS status, hepcidin and FGF-21 were independent determinants of arterial stiffness in PD patients. Therefore, definition and improvement of these new parameters will be helpful to reduce the cardiovascular disease risk and mortality in CAPD patients.
authors.affiliation: Department of Nephrology, Faculty of Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey, drsenaulu@yahoo.com.
authors.forename: Sena Memnune
authors.initials: SM
authors.lastname: Ulu
authors.forename: Seref
authors.initials: S
authors.lastname: Yuksel
authors.forename: Atila
authors.initials: A
authors.lastname: Altuntaş
authors.forename: Emre
authors.initials: E
authors.lastname: Kacar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ahsen
authors.forename: Abdullah
authors.initials: A
authors.lastname: Altug
authors.forename: Sefa
authors.initials: S
authors.lastname: Celik
authors.forename: M Tugrul
authors.initials: MT
authors.lastname: Sezer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011446:Prospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D064451:Hepcidins; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors