title: Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: a critical and meta-analysis.
abstract: BACKGROUND
  Poor solubility and dissolution of drugs are the major challenges in drug formulation and delivery. In order to improve the solubility and dissolution profile of drugs, various methods have been investigated so far. The cyclodextrin (CD) complexation and phospholipid (PL) complexation are among the exhaustively investigated methods employed for more precise improvement of the solubility and dissolution of poorly water-soluble drugs.
  
  
  METHODS
  The article discusses the CD and PL complexation techniques of solubility and dissolution enhancement. Various studies reporting the CD and PL complexation as the potential approaches to improve the dissolution, absorption and the bioavailability of the drugs have been discussed. The article critically reviews the physicochemical properties of CDs and PLs, eligibility of drugs for both the complexation, thermodynamics of complexation, methods of preparation, characterization, advantages, limitation and the meta-analysis of some studies for both the techniques.
  
  
  CONCLUSIONS
  The CD and PL complexation techniques are very useful in improving solubility and dissolution (and hence the bioavailability) of biopharmaceutical classification system Class II and Class IV drugs. The selection of a particular kind of complexation can be made on the basis of eligibility criteria (of drugs) for the individual techniques, cost, stability and effectiveness of the complexes.
authors.affiliation: H.N.B. Garhwal University Srinagar (Garhwal), Department of Pharmaceutical Sciences, Chauras Campus , Chauras, Srinagar (Garhwal), 246174 , India semaltyajay@yahoo.co.in.
authors.forename: Ajay
authors.initials: A
authors.lastname: Semalty
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D003505:Cyclodextrins; D010743:Phospholipids; D014867:Water
keywords: X-ray powder diffraction; complexation; differential scanning calorimetry; dissolution; phospholipids; solubility