title: Sulfoximine-directed ruthenium-catalyzed ortho-C-H alkenylation of (hetero)arenes: synthesis of EP3 receptor antagonist analogue.
abstract: The reusable sulfoximine directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C-H alkenylation of arenes and heteroarenes with acrylates and α,β-unsaturated ketones/vinyl sulfone is shown. The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinolinones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue.
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad 500046, India.
authors.forename: M Ramu
authors.initials: MR
authors.lastname: Yadav
authors.forename: Raja K
authors.initials: RK
authors.lastname: Rit
authors.forename: Majji
authors.initials: M
authors.lastname: Shankar
authors.forename: Akhila K
authors.initials: AK
authors.lastname: Sahoo
mesh_terms: D000478:Alkylation; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D058308:Receptors, Prostaglandin E, EP3 Subtype / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D058308:Receptors, Prostaglandin E, EP3 Subtype; D012428:Ruthenium