title: Expression and prognostic value of aquaporin 1, 3 in cervical carcinoma in women of Uygur ethnicity from Xinjiang, China.
abstract: BACKGROUND
  Overexpression of several aquaporins has been reported in different types of human cancer but the role of aquaporins in carcinogenesis has not yet been clearly defined. There is few report concerning role of aquaporins in human cervical carcinogenesis so far. Here, we determined the expression and prognostic value of aquaporin 1, 3 in cervical carcinoma in Chinese women of Uygur ethnicity.
  
  
  RESULTS
  Real-time PCR analyses demonstrated aquaporin 1, 3 mRNA were differentially expressed in cervical carcinoma, CIN 2-3 and mild cervicitis. Immunofluorescent and immunohistochemical analyses demonstrated aquaporin 1 was predominantly localized to stromal endothelial cells in cervical lesions. Aquaporin 3 was localized to the membrane of normal squamous epithelium, CIN and carcinoma cells. Aquaporin 1 and 3 were upregulated in cervical cancer compared to mild cervicitis and CIN2-3 (P<0.05); Tumor expression of aquaporin 1, 3 significantly increased in advanced stage disease, and patients with deeper tumor infiltration, lymph node metastases or larger tumor volume (P<0.05). Multivariate analysis demonstrated that aquaporin 1, 3 were not independent prognostic factors in cervical carcinoma.
  
  
  CONCLUSIONS
  Aquaporins may participate in the initiation and progression of cervical carcinoma by promoting tumor growth, invasion or lymph node metastasis. Further study is required to determine whether aquaporins have potential as prognostic factors in cervical cancer.
authors.affiliation: Department of Gynecology, Third Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Pathology, Basic Medicine College of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pathology, Basic Medicine College of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Reshalaity
authors.initials: R
authors.lastname: Amiduo
authors.affiliation: Department of Pathology, Basic Medicine College of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Talaf
authors.initials: T
authors.lastname: Tuokan
authors.affiliation: Department of Pathology, Basic Medicine College of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Lalai
authors.initials: L
authors.lastname: Suzuk
mesh_terms: D000328:Adult; D000368:Aged; D051398:Aquaporin 1 / Q000235:genetics*; D051400:Aquaporin 3 / Q000235:genetics*; D044466:Asian People; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D002681:China / Q000453:epidemiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D002575:Uterine Cervicitis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics
chemical_list: D051398:Aquaporin 1; D051400:Aquaporin 3