title: Application of iPS cells in dental bioengineering and beyond.
abstract: The stem-cell-based tissue-engineering approaches are widely applied in establishing functional organs and tissues for regenerative medicine. Successful generation of induced pluripotent stem cells (iPS cells) and rapid progress of related technical platform provide great promise in the development of regenerative medicine, including organ regeneration. We have previously reported that iPS cells could be an appealing stem cells source contributing to tooth regeneration. In the present paper, we mainly review the application of iPS technology in dental bioengineering and discuss the challenges for iPS cells in the whole tooth regeneration.
authors.affiliation: CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell Biology and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Science Park, Guangzhou, 510530, People's Republic of China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Liu
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shubin
authors.initials: S
authors.lastname: Chen
authors.forename: Jinglei
authors.initials: J
authors.lastname: Cai
authors.forename: Duanqing
authors.initials: D
authors.lastname: Pei
mesh_terms: D000818:Animals; D057005:Bioengineering; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D014070:Tooth / Q000166:cytology*