title: New investigational drugs for the treatment of neuropathic pain.
abstract: BACKGROUND
  Neuropathic pain (NP) is a chronic condition that arises from a lesion or dysfunction of the somatosensory nervous system. However, there are several new targets and novel technologies in the pipeline to address this unmet medical need.
  
  
  METHODS
  In this review, the authors briefly discuss a direction of the development of agents that could be potentially used in NP treatment. Special attention is paid to 1.7-selective voltage-gated sodium channels, N-type voltage-gated calcium channels, angiotensin II (Ang II) AT₂ receptors and nerve growth factor (NGF) as promising targets for new drugs. Furthermore, the article also presents and discusses, in detail, the results of Phase II clinical studies with the AT₂ receptor antagonist - EMA401 in NP (the results of Phase II clinical trials of other described compounds are not available, yet).
  
  
  CONCLUSIONS
  There is a real hope that new drugs for NP may be available soon. This hope is based on advancing methods of genomics, developing new targets and more efficient drug screening. Some forms of direct influence on voltage-gated ion channels have a place in the treatment of NP, while the development of entirely novel Ang II AT₂ receptor antagonists or NGF inhibitors may be available for many chronic pain sufferers in the foreseeable future.
authors.affiliation: Jagiellonian University, Faculty of Pharmacy , Medyczna 9 St., 30-688 Kraków , Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Sałat
authors.forename: Paula
authors.initials: P
authors.lastname: Kowalczyk
authors.forename: Beata
authors.initials: B
authors.lastname: Gryzło
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kulig
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D015195:Drug Design; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use*; D023281:Genomics / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy; D009437:Neuralgia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000700:Analgesics; D015507:Drugs, Investigational
keywords: N-type calcium channel antagonists; Phase II clinical studies; angiotensin II AT2 receptor antagonists; inhibitors of Nav1.7 channels; neuropathic pain; tanezumab