title: Gadolinium Complex of (125)I/(127)I-RGD-DOTA Conjugate as a Tumor-Targeting SPECT/MR Bimodal Imaging Probe.
abstract: The work describes the synthesis and in vivo application of [Gd(L)(H2O)]·xH2O, where L is a ((125)I/(127)I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, ((125)I/(127)I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = (125)I-RGD-DOTA) and natural (1b, L = (127)I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.
authors.affiliation: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Ji-Ae
authors.initials: JA
authors.lastname: Park
authors.affiliation: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Wonho
authors.initials: W
authors.lastname: Lee
authors.affiliation: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Sang Moo
authors.initials: SM
authors.lastname: Lim
authors.affiliation: Department of Applied Chemistry, Kyungpook National University , Daegu 702-701, Republic of Korea.
authors.forename: Tae-Jeong
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Department of Molecular Medicine, Kyungpook National University , Daegu 700-422, Republic of Korea.
authors.forename: Jeongsoo
authors.initials: J
authors.lastname: Yoo
authors.affiliation: Department of Molecular Medicine, Kyungpook National University , Daegu 700-422, Republic of Korea.
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
keywords: RGD peptide; SPECT/MR; dual modality; small molecule; tumor targeting