title: Salicylate-induced auditory perceptual disorders and plastic changes in nonclassical auditory centers in rats.
abstract: Previous studies have shown that sodium salicylate (SS) activates not only central auditory structures, but also nonauditory regions associated with emotion and memory. To identify electrophysiological changes in the nonauditory regions, we recorded sound-evoked local field potentials and multiunit discharges from the striatum, amygdala, hippocampus, and cingulate cortex after SS-treatment. The SS-treatment produced behavioral evidence of tinnitus and hyperacusis. Physiologically, the treatment significantly enhanced sound-evoked neural activity in the striatum, amygdala, and hippocampus, but not in the cingulate. The enhanced sound evoked response could be linked to the hyperacusis-like behavior. Further analysis showed that the enhancement of sound-evoked activity occurred predominantly at the midfrequencies, likely reflecting shifts of neurons towards the midfrequency range after SS-treatment as observed in our previous studies in the auditory cortex and amygdala. The increased number of midfrequency neurons would lead to a relative higher number of total spontaneous discharges in the midfrequency region, even though the mean discharge rate of each neuron may not increase. The tonotopical overactivity in the midfrequency region in quiet may potentially lead to tonal sensation of midfrequency (the tinnitus). The neural changes in the amygdala and hippocampus may also contribute to the negative effect that patients associate with their tinnitus.
authors.affiliation: Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.
authors.forename: Guang-Di
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Radziwon
authors.affiliation: Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.
authors.forename: Nina
authors.identifier: 0000-0002-3040-4538
authors.initials: N
authors.lastname: Kashanian
authors.affiliation: Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.
authors.forename: Senthilvelan
authors.initials: S
authors.lastname: Manohar
authors.affiliation: Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.
authors.forename: Richard
authors.identifier: 0000-0001-9061-8602
authors.initials: R
authors.lastname: Salvi
mesh_terms: D000161:Acoustic Stimulation; D000679:Amygdala / Q000502:physiology; D000818:Animals; D001308:Auditory Perceptual Disorders / Q000139:chemically induced* / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology; D004567:Electrodes, Implanted; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006179:Gyrus Cinguli / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D008144:Loudness Perception / Q000502:physiology; D008297:Male; D017072:Neostriatum / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D013216:Reflex, Startle / Q000502:physiology; D012459:Salicylates; D014012:Tinnitus / Q000503:physiopathology
chemical_list: D012459:Salicylates