title: Combination therapy of gamma-aminobutyric acid derivative promotes proton pump inhibitor based healing of reflux esophagitis in animal model.
abstract: BACKGROUND
  The present study was undertaken to elucidate the effect of omeprazole and baclofen on experimental esophagitis in albino rats.
  
  
  METHODS
  Groups of rats, fasted overnight received normal saline (3 ml/kg, ip; sham control) or toxic control (3 ml/kg, ip) or omeprazole (30 mg/kg, ip) or baclofen (20 mg/kg, ip) or their combinations, were subjected to the pylorus and forestomach ligation. Animals were sacrificed after 6 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase and SOD.
  
  
  RESULTS
  Treatment with omeprazole and baclofen significantly inhibited the gastric secretion, total acidity and esophagitis index. The treatment also helped to restore the altered level's oxidative stress parameters to normal.
  
  
  CONCLUSIONS
  The beneficial effect of omeprazole and baclofen against GERD could be conglomerately attributed to the antisectretory action of omeprazole and reduction in the tracheal lower esophageal sphincter release rate by baclofen.
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Khinchi
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Saha
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.
authors.forename: Shubhini A
authors.initials: SA
authors.lastname: Saraf
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India. Electronic address: gauravpharm@gmail.com.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kaithwas
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004942:Esophagitis, Peptic / Q000188:drug therapy* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives*
chemical_list: D054328:Proton Pump Inhibitors; D005680:gamma-Aminobutyric Acid; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Antisecretory; Baclofen; Esophagitis; Gamma-aminobutyric acid; Omeprazole