title: Id transcriptional regulators in adipogenesis and adipose tissue metabolism.
abstract: Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins are implicated in the regulation of various cellular mechanisms such as cell proliferation, cellular differentiation, cell fate determination, angiogenesis and tumorigenesis. A handful of recent studies also disclosed that Id proteins have critical functions in adipocyte differentiation and adipose tissue metabolism. Here, we reviewed the progress made thus far in understanding the specific functions of Id proteins in adipose tissue differentiation and metabolism. In addition to reviewing the known mechanisms of action, we also discuss possible additional mechanisms in which Id proteins might participate in regulating adipogenic and metabolic pathways.
authors.forename: Mallikarjun
authors.initials: M
authors.lastname: Patil
authors.forename: Bal Krishan
authors.initials: BK
authors.lastname: Sharma
authors.forename: Ande
authors.initials: A
authors.lastname: Satyanarayana
mesh_terms: D050156:Adipogenesis / Q000235:genetics*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D051796:Inhibitor of Differentiation Proteins / Q000235:genetics*; D008957:Models, Genetic; D020033:Protein Isoforms / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051796:Inhibitor of Differentiation Proteins; D020033:Protein Isoforms