title: MOPED 2.5--an integrated multi-omics resource: multi-omics profiling expression database now includes transcriptomics data.
abstract: Multi-omics data-driven scientific discovery crucially rests on high-throughput technologies and data sharing. Currently, data are scattered across single omics repositories, stored in varying raw and processed formats, and are often accompanied by limited or no metadata. The Multi-Omics Profiling Expression Database (MOPED, http://moped.proteinspire.org ) version 2.5 is a freely accessible multi-omics expression database. Continual improvement and expansion of MOPED is driven by feedback from the Life Sciences Community. In order to meet the emergent need for an integrated multi-omics data resource, MOPED 2.5 now includes gene relative expression data in addition to protein absolute and relative expression data from over 250 large-scale experiments. To facilitate accurate integration of experiments and increase reproducibility, MOPED provides extensive metadata through the Data-Enabled Life Sciences Alliance (DELSA Global, http://delsaglobal.org ) metadata checklist. MOPED 2.5 has greatly increased the number of proteomics absolute and relative expression records to over 500,000, in addition to adding more than four million transcriptomics relative expression records. MOPED has an intuitive user interface with tabs for querying different types of omics expression data and new tools for data visualization. Summary information including expression data, pathway mappings, and direct connection between proteins and genes can be viewed on Protein and Gene Details pages. These connections in MOPED provide a context for multi-omics expression data exploration. Researchers are encouraged to submit omics data which will be consistently processed into expression summaries. MOPED as a multi-omics data resource is a pivotal public database, interdisciplinary knowledge resource, and platform for multi-omics understanding.
authors.affiliation: 1 Bioinformatics and High-Throughput Analysis Laboratory, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Montague
authors.forename: Larissa
authors.initials: L
authors.lastname: Stanberry
authors.forename: Roger
authors.initials: R
authors.lastname: Higdon
authors.forename: Imre
authors.initials: I
authors.lastname: Janko
authors.forename: Elaine
authors.initials: E
authors.lastname: Lee
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Anderson
authors.forename: John
authors.initials: J
authors.lastname: Choiniere
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Stewart
authors.forename: Gregory
authors.initials: G
authors.lastname: Yandl
authors.forename: William
authors.initials: W
authors.lastname: Broomall
authors.forename: Natali
authors.initials: N
authors.lastname: Kolker
authors.forename: Eugene
authors.initials: E
authors.lastname: Kolker
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D033181:Information Dissemination; D040901:Proteomics / Q000379:methods; D012984:Software