title: [Effect of vitamin d receptor polymorphisms on the development and progression of malignant melanoma].
abstract: BACKGROUND
  Malignant melanoma is one of the most aggressive cutaneous tumors in men and women. The risk of developing a malignant melanoma depends on several external factors along with deregulation of mutual interaction of genotype and phenotype. Nowadays, growing attention is focused on the study of the interactions of the active form of vitamin D3 with its receptor and inhibitory effect of vitamin D3 receptor polymorphisms on multiple signaling pathways involved in proliferative and metastatic processes.
  
  
  OBJECTIVE
  This review article addresses the relationship between factors involved in the development of malignant melanoma through Hedgehog signaling pathway (HH). It summarizes current knowledge of malignant melanoma in regard to the role of the active form of vitamin D3 binding to vitamin D3 receptor (VDR), as well as it describes the influence of polymorphisms of VDR on the inhibition of HH. Understanding of these mechanisms and critical assessment of available data is beneficial to both primary and secondary prevention of malignant melanoma particularly by means of chemo -preventive substances.
authors.forename: I
authors.initials: I
authors.lastname: Spaková
authors.forename: M
authors.initials: M
authors.lastname: Bilecová-Rabajdová
authors.forename: M
authors.initials: M
authors.lastname: Zábavníková
authors.forename: P
authors.initials: P
authors.lastname: Urban
authors.forename: M
authors.initials: M
authors.lastname: Mareková
mesh_terms: D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D010641:Phenotype; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D014807:Vitamin D / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D018167:Receptors, Calcitriol; D014807:Vitamin D