title: Negatively-charged helices in the gas phase.
abstract: A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. carlsone@indiana.edu.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Johnson
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Dilger
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Glover
authors.forename: David E
authors.initials: DE
authors.lastname: Clemmer
authors.forename: Erin E
authors.initials: EE
authors.lastname: Carlson
mesh_terms: D005740:Gases; D006860:Hydrogen Bonding; D013058:Mass Spectrometry; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D055672:Static Electricity
chemical_list: D005740:Gases; D010455:Peptides; C019529:polyalanine