title: Micro-RNAs, New performers in multiple myeloma bone marrow microenvironment.
abstract: The established interaction between multiple myeloma cells and bone marrow microenvironment components provides malignant cells with various survival, growth and drug resistance signals. As a new concept, identification of miRNAs and their related gene/protein targets, signaling molecules and pathways in the context of bone marrow microenvironment will help understanding more deeply the pathogenesis of the disease and possible mechanisms underlying environment-induced drug resistance. Recent studies suggest that bone marrow stromal cells can modulate some miRNAs (miR-21, miR-15a/16) in multiple myeloma cells through direct adhesion, cytokine secretion or transfer of miRNA-containing exosomes, however; the specific miRNA targets are not clear. In spite of a remarkable progress in understanding myeloma biology and therapy, the disease persists to be hard to treat. This review will discuss the most recent findings on miRNAs expression and function in the context of bone marrow microenvironment highlighting the miRNAs as potential therapeutic targets in multiple myeloma.
authors.affiliation: Division of Molecular and Cellular Biology, Toronto General Research Institute, Toronto, Canada ; Department of Laboratory Medicine & Pathobiology, University of Toronto, 172 St George St, Toronto, ON M5R 0A3, Canada.
authors.forename: Jahangir
authors.initials: J
authors.lastname: Abdi
authors.affiliation: Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
authors.forename: Lugui
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Division of Molecular and Cellular Biology, Toronto General Research Institute, Toronto, Canada ; Department of Laboratory Medicine & Pathobiology, University of Toronto, 172 St George St, Toronto, ON M5R 0A3, Canada ; Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China ; Department of Laboratory Hematology, Laboratory Medicine Program, Toronto General Hospital, University Health Network, 200 Elizabeth Street, 11E-413, Toronto, Ontario M5G 2C4, Canada.
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
keywords: Bone marrow stroma; CAMDR; Multiple myeloma; miRNA