title: Role of NF-κB-dependent signaling and p38 MAPK signaling pathway in the control of hemopoiesis during cytostatic administration.
abstract: The study examines the role of signal pathways in triggering the compensatory reactions in the blood system in response to the cytostatic administration. In vitro experiments elucidated the involvement of protein kinase p38 in the synthesis of granulocytic CSF by cells of hemopoietic microenvironment. The important role of the transcriptional factor NF-κB and protein kinase p38 in limitation of the processes of maturation of the hemopoietic precursors was demonstrated.
authors.affiliation: Research Institute of Pharmacology, Siberian Division of the Russian Academy of Sciences, Tomsk, Russia, digay_am@pharmso.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D041905:Erythroid Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis / Q000378:metabolism; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006410:Hematopoiesis / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D019653:Myeloablative Agonists / Q000494:pharmacology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D061251:Primary Cell Culture; D011725:Pyridines / Q000494:pharmacology; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D007093:Imidazoles; D019653:Myeloablative Agonists; D016328:NF-kappa B; D011725:Pyridines; D006052:Gold Sodium Thiomalate; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide; D048051:p38 Mitogen-Activated Protein Kinases; C093642:SB 203580