title: Intra-Articular Analgesia and Steroid Reduce Pain Sensitivity in Knee OA Patients: An Interventional Cohort Study.
abstract: Objectives. To assess the effects of intra-articular therapy on pain sensitivity in the knee and surrounding tissues in knee OA patients. Methods. Twenty-five knee OA patients with symptomatic knee OA were included in this interventional cohort study. Pressure pain thresholds (PPT) were recorded before, immediately after, and two weeks after ultrasound guided intra-articular injection of lidocaine combined with glucocorticosteroid. Computer-controlled and manual pressure algometers were used to assess PPT on the knee, vastus lateralis, tibialis anterior, and the extensor carpi radialis longus muscles (control site). Results. Significantly increased PPTs were found following intra-articular injection, at both the knee (P < 0.0001) and the surrounding muscles (P < 0.042). The treatment effects were sustained for two weeks, and at some points the effect was even greater at two weeks (P < 0.026). Albeit not statistically significant, a similar trend was observed at the control site. Conclusions. Intra-articular anesthesia, combined with glucocorticosteroid, reduced pain sensitivity in both the knee and surrounding muscles for at least two weeks.
authors.affiliation: Clinical Motor Function Laboratory, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Nordre Fasanvej 57, Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark ; Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.
authors.forename: Tanja Schjødt
authors.initials: TS
authors.lastname: Jørgensen
authors.affiliation: Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Graven-Nielsen
authors.affiliation: Clinical Motor Function Laboratory, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Nordre Fasanvej 57, Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Ellegaard
authors.affiliation: Clinical Motor Function Laboratory, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Nordre Fasanvej 57, Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark ; Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.
authors.forename: Bente
authors.initials: B
authors.lastname: Danneskiold-Samsøe
authors.affiliation: Clinical Motor Function Laboratory, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Nordre Fasanvej 57, Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark ; Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Bliddal
authors.affiliation: Clinical Motor Function Laboratory, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Nordre Fasanvej 57, Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark.
authors.forename: Marius
authors.initials: M
authors.lastname: Henriksen