title: Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk.
abstract: BACKGROUND
  To investigate the possible association of the rs2165241 polymorphism (C > T) in LOXL1 gene with the risk of primary open-angle glaucoma in a Mediterranean population.
  
  
  METHODS
  The analysis of genetic polymorphisms was performed by standard TaqMan allelic discrimination technique, using a 7900HT Sequence Detection System (Applied Biosystems).
  
  
  RESULTS
  In a recessive genetic model, the T allele of the rs2165241 polymorphism was significantly associated with the risk of primary open-angle glaucoma (TT vs. CC: odds ratios = 2.19, 95% confidence interval = [1.33-3.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant (TT vs. CC: odds ratios = 2.07, 95% confidence interval = [1.20-3.57]).
  
  
  CONCLUSIONS
  This polymorphism seems to be associated with high risk for primary open-angle glaucoma in a Mediterranean population.
authors.affiliation: Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain; Ophthalmology Research Unit 'Santiago Grisolia', Valencia, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Zanon-Moreno
authors.forename: Laura
authors.initials: L
authors.lastname: Zanon-Moreno
authors.forename: Carolina
authors.initials: C
authors.lastname: Ortega-Azorin
authors.forename: Eva M
authors.initials: EM
authors.lastname: Asensio-Marquez
authors.forename: Jose Javier
authors.initials: JJ
authors.lastname: Garcia-Medina
authors.forename: Pedro
authors.initials: P
authors.lastname: Sanz
authors.forename: Maria D
authors.initials: MD
authors.lastname: Pinazo-Duran
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovás
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D016022:Case-Control Studies; D017889:Exfoliation Syndrome / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D019083:Mediterranean Region; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain; D014794:Visual Fields / Q000502:physiology
chemical_list: D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human
keywords: LOXL1 polymorphism; Mediterranean population; genetics; primary open-angle glaucoma