title: Copper-catalyzed [18F]fluorination of (mesityl)(aryl)iodonium salts.
abstract: A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA.
authors.affiliation: Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ichiishi
authors.forename: Allen F
authors.initials: AF
authors.lastname: Brooks
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Topczewski
authors.forename: Melissa E
authors.initials: ME
authors.lastname: Rodnick
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Scott
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D012492:Salts
chemical_list: D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; D009861:Onium Compounds; D012492:Salts; D003300:Copper