title: Antibacterial effects of fluoride varnish compared with chlorhexidine plus fluoride in disabled children.
abstract: OBJECTIVE
  To evaluate the effects of fluoride varnish vs a combination of chlorhexidine-thymol varnish plus a gel containing chlorhexidine and fluoride on oral hygiene and caries prevention in disabled children.
  
  
  METHODS
  Ninety patients aged 3-17 years who were treated under general anaesthesia were randomly assigned into three groups as follows: group 1: Fluor Protector (0.1% fluoride varnish); group 2: Cervitec Plus (1% chlorhexidine- 1% thymol varnish) + Cervitec Gel (0.2% chlorhexidine-0.2% sodium fluoride); group 3: control (toothbrushing only). Mutans streptococci (MS) and lactobacilli (LB) levels, visible plaque index (VPI) and gingival bleeding index (GBI) were evaluated at four stages: T0, before general anaesthesia; T1, one month after treatment; T2, six months after treatment; T3, twelve months after treatment. The data were evaluated using Kruskal-Wallis and Mann-Whitney U-tests (P < 0.05).
  
  
  RESULTS
  Groups 1 and 2 showed significantly lower scores than group 3 for all parameters at T1 and T2. No statistically significant difference was detected among any of the the groups at T3 (P > 0.05).
  
  
  CONCLUSIONS
  The use of materials that include both fluoride and chlorhexidine as routine treatment of children with disability may increase the success of restorations by improving oral hygiene, reduce the need for future restorative treatments and thus the need for general anaesthesia.
authors.forename: Ozgul
authors.initials: O
authors.lastname: Baygin
authors.forename: Tamer
authors.initials: T
authors.lastname: Tuzuner
authors.forename: Adem
authors.initials: A
authors.lastname: Kusgoz
authors.forename: Ahmet Can
authors.initials: AC
authors.lastname: Senel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tanriver
authors.forename: Ipek
authors.initials: I
authors.lastname: Arslan
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D058491:Bacterial Load / Q000187:drug effects; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002710:Chlorhexidine / Q000627:therapeutic use*; D003730:Dental Care for Persons with Disabilities; D003731:Dental Caries / Q000517:prevention & control; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use; D019988:Children with Disabilities; D004338:Drug Combinations; D005260:Female; D005460:Fluorides, Topical / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects; D008297:Male; D009910:Oral Hygiene; D010512:Periodontal Index; D011140:Polyurethanes / Q000627:therapeutic use*; D012463:Saliva / Q000382:microbiology; D012821:Silanes / Q000627:therapeutic use*; D013295:Streptococcus mutans / Q000187:drug effects; D013943:Thymol / Q000627:therapeutic use*; D014099:Toothbrushing / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D003802:Dentifrices; D004338:Drug Combinations; D005460:Fluorides, Topical; D011140:Polyurethanes; D012821:Silanes; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; C022599:Fluor Protector; D002710:Chlorhexidine