title: Response-Adaptive Allocation for Circular Data.
abstract: Response-adaptive designs are used in phase III clinical trials to allocate a larger proportion of patients to the better treatment. Circular data is a natural outcome in many clinical trial setup, e.g., some measurements in opthalmologic studies, degrees of rotation of hand or waist, etc. There is no available work on response-adaptive designs for circular data. With reference to a dataset on cataract surgery we provide some response-adaptive designs where the responses are of circular nature and propose some test statistics for treatment comparison under adaptive data allocation procedure. Detailed simulation study and the analysis of the dataset, including redesigning the cataract surgery data, are carried out.
authors.affiliation: a Applied Statistics Unit , Indian Statistical Institute , Kolkata , India.
authors.forename: Atanu
authors.initials: A
authors.lastname: Biswas
authors.forename: Somak
authors.initials: S
authors.lastname: Dutta
authors.forename: Arnab Kumar
authors.initials: AK
authors.lastname: Laha
authors.forename: Partho K
authors.initials: PK
authors.lastname: Bakshi
mesh_terms: D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data*; D003627:Data Interpretation, Statistical; D006801:Humans; D015233:Models, Statistical; D012107:Research Design; D016896:Treatment Outcome
keywords: Circular data; Ethical allocation; Optimal allocation; Response-adaptive design; von Mises distribution