title: Using medicinal chemistry to solve an old medical mystery.
abstract: The logic behind the traditional medicinal chemistry technique of designing a synthetic enzyme substrate to mimic a natural one is used to uncover the identity of the unknown cause of two legacy industrial diseases by comparing the reported symptoms to two side effects of a modern synthetic.
authors.affiliation: Markle and Hinshaw Gynecology and Harris Regional Hospital , 7190 Ellijay Road, Franklin, North Carolina 28734, United States.
authors.forename: William B
authors.initials: WB
authors.lastname: Hinshaw
authors.affiliation: Department of Chemistry, Duke University , 15 Aldersgate Court, Durham, North Carolina 27705, United States.
authors.forename: Louis D
authors.initials: LD
authors.lastname: Quin