title: Effects of 5-amino salicylic acid on the expression of multidrug resistance gene in ulcerative colitis.
abstract: OBJECTIVE
  To study the effect of drugs on the expression of multidrug resistance gene in ulcerative colitis.
  
  
  METHODS
  The expressions of multidrug resistance (MDR) 1 gene and its product P-Gp were detected by reverse transcription-polymerase chain reaction and immunohistochemistry to realize the impact of drugs on ulcerative colitis.
  
  
  RESULTS
  MDR1 gene and P-Gp did not exhibit significant difference (P > 0.05) before and after amino salicylic acid drug treatment. Compared with the control group, their expressions before treatment in the ineffective corticosteroid- and immunosuppressant-treated groups did not exhibit significant difference (P > 0.05). Their pre- and post-treatment expressions in the ineffective groups were compared with those in the normal control group and in the effective group, and significant differences were observed (P < 0.05).
  
  
  CONCLUSIONS
  5-Amino salicylic acid drugs have little effect on the expression of MDR1 and its product P-Gp. The expressions of MDR1 and P-Gp were much higher in groups that showed ineffectiveness for corticosteroids and immunosuppressants after treatment.
authors.forename: Ying-Jian
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zheng
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Jin
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Wang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis* / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D019804:Mesalamine / Q000494:pharmacology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D055815:Young Adult
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D019804:Mesalamine