title: Current issues in chronic graft-versus-host disease.
abstract: Chronic graft-versus-host disease (GVHD) is a frequent and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. Increased transplantation of older patients and the more frequent use of unrelated donors has led to increased numbers of patients with this painful complication. Recent advances have been made in understanding the pathophysiology of chronic GVHD and in establishing precise criteria for diagnosis and classification of disease manifestations. These advances will hopefully pave the way for improving both the prophylaxis and treatment of chronic GVHD.
authors.affiliation: Assistance Publique-Hopitaux de Paris, Hospital Saint Louis, Division of Hematology/Immunology/Oncology, Hematology Transplantation, Paris, France; University Paris VII, Denis Diderot, Paris, France; INSERM U1160, Team GVHD and Allogeneic Transplantation, Paris, France;
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA; and Harvard Medical School, Boston, MA.
authors.forename: Jerome
authors.initials: J
authors.lastname: Ritz
mesh_terms: D064591:Allografts; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006086:Graft vs Host Disease / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D018448:Models, Immunological; D011379:Prognosis; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology