title: Characterization of pituitary tumor transforming gene in meningiomas.
abstract: BACKGROUND
  Pituitary tumor transforming gene (PTTG) is an oncogene and has been detected in several tumors of unrelated histological origin. However, its role in meningiomas is unknown so far. We aim to investigate PTTG expression in intracranial meningiomas, and clarify the relationship between PTTG and the histopathological types of tumors.
  
  
  METHODS
  Over a 7-year period, 195 meningioma specimens were collected from 195 patients. Seventeen nonneoplastic meningeal tissues were used as controls. We analyze PTTG expression by tissue microarray with immunohistochemistry.
  
  
  RESULTS
  Immunoexpression of PTTG was identified in 172 of 195 meningiomas, accounting for 88.2%. All of immunoexpression of tumors were found to be cytoplasmic, and no nuclear expression was observed. In the control group, there were 3 of 17 specimens (17.6%) with positive PTTG expression. The percentage of high expression WHO subtypes of meningiomas ranged from 0% to 95.7%. We further stratified the tumors into 3 subgroups based on pathological grading (WHO grade I, WHO grade II and III, control), and there was significant intergroup difference in PTTG expression (p<0.001).
  
  
  CONCLUSIONS
  This study demonstrated that PTTG was expressed in most of meningioma tissues, and the degree of PTTG immunostaining was variable in the subtypes of tumors. Further investigations into PTTG expression are required to broaden the pathogenesis research of meningiomas.
authors.affiliation: Department of Neurosurgery, Yangzhou Medical College, Yangzhou University, Yangzhou, China.
authors.forename: Hengzhu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Yangzhou Medical College, Yangzhou University, Yangzhou, China.
authors.forename: Renfei
authors.initials: R
authors.lastname: Du
authors.affiliation: Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Yangzhou Medical College, Yangzhou University, Yangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: She
authors.affiliation: Department of Neurosurgery, Yangzhou Medical College, Yangzhou University, Yangzhou, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Yangzhou Medical College, Yangzhou University, Yangzhou, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: newlupin2002@yahoo.com.tw.
authors.forename: Aij-Lie
authors.initials: AL
authors.lastname: Kwan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D064249:Securin / Q000378:metabolism*; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D064249:Securin; C578002:pituitary tumor-transforming protein 1, human
keywords: Immunohistochemistry; Meningioma; Pituitary tumor transforming gene; Tissue microarray