title: Peritoneal transport rate, systemic inflammation, and residual renal function determine peritoneal protein clearance in continuous ambulatory peritoneal dialysis patients.
abstract: BACKGROUND
  Peritoneal protein clearance (Pcl) is related to the mortality of patients on continuous ambulatory peritoneal dialysis (CAPD) as well as technique failure. In this prospective observational study, we aimed to investigate factors associated with the level of Pcl.
  
  
  METHODS
  We prospectively enrolled 344 prevalent CAPD patients. A standard peritoneal equilibrium test was conducted for each patient. Baseline demographics, biochemistry, and Pcl were recorded.
  
  
  RESULTS
  The average Pcl of the patients was 97.40 ± 54.14 mL/day. Peritoneal transport level, serum high-sensitivity C-reactive protein (hsCRP), and residual glomerular filtration rate (rGFR) were independently related to Pcl. The standard β values were 0.53, 0.17, and -0.10, respectively. Moreover, compared with non-diabetic patients, diabetic patients had a non-significantly higher level of Pcl (104.90 ± 48.65 vs. 96.15 ± 54.97 mL/day; P = 0.06).
  
  
  CONCLUSIONS
  Continuous ambulatory peritoneal dialysis patients lose a high amount of protein through the peritoneum each day. The Pcl value is positively related to the level of peritoneal transport and hsCRP and negatively related to the rGFR.
authors.affiliation: Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China, tmka1986@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhong
authors.forename: Yongshu
authors.initials: Y
authors.lastname: Diao
authors.forename: Min
authors.initials: M
authors.lastname: Qin
authors.forename: Xueli
authors.initials: X
authors.lastname: Zhou
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D010537:Peritoneum / Q000378:metabolism*; D010539:Permeability; D011446:Prospective Studies; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins