title: Visceral leishmaniasis with cutaneous symptoms in a patient treated with infliximab followed by fatal consequences.
abstract: Leishmaniasis is an infectious disease caused by parasitic flagellates of the genus Leishmania. The authors present a case of 44-year-old man with Crohn's disease treated successfully with infliximab. This case report shows rare visceral leishmaniasis with cutaneous symptoms in an immunocompromised patient. Skin manifestations may occur before or after the visceral infection and they are often diverse.
authors.affiliation: Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Juzlova
authors.forename: Jana
authors.initials: J
authors.lastname: Votrubova
authors.forename: Denisa
authors.initials: D
authors.lastname: Kacerovska
authors.forename: Milan
authors.initials: M
authors.lastname: Lukas
authors.forename: Martin
authors.initials: M
authors.lastname: Bortlik
authors.forename: Hana
authors.initials: H
authors.lastname: Rohacova
authors.forename: Eva
authors.initials: E
authors.lastname: Nohynkova
authors.forename: Nadezda
authors.initials: N
authors.lastname: Vojackova
authors.forename: Jorga
authors.initials: J
authors.lastname: Fialova
authors.forename: Jana
authors.initials: J
authors.lastname: Hercogova
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D000981:Antiprotozoal Agents / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D017809:Fatal Outcome; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D000069285:Infliximab; D016773:Leishmaniasis, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D007898:Leishmaniasis, Visceral / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D008297:Male; D008536:Meglumine / Q000009:adverse effects; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000981:Antiprotozoal Agents; D005765:Gastrointestinal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000069285:Infliximab
keywords: immunosuppression; skin manifestation; visceral leishmaniasis