title: Coordination behavior and bio-potent aspects of Ni(II) with 2-aminobenzamide and some amino acid mixed ligands--Part II: Synthesis, spectral, morphological, pharmacological and DNA interaction studies.
abstract: A series of novel bioactive mixed ligand Ni(II) complexes (1a-1d) have been synthesised by using 2-aminobenzamide (2AB) and some bio-relevant amino acid ligands. The synthesised Ni(II) complexes were structurally characterized by various physico-chemical and spectral studies. Elemental analysis and molar conductance values suggest that 1:1:1 stoichiometry with non-electrolytic nature. Based on the spectral studies, both the ligands act as bidentate and they chelate with Ni(II) ion via amino-NH2 and amido-O and deprotonated carboxylato-O and amino-NH2 atoms respectively to form a stable six, five membered chelate rings with mononuclear octahedral geometry. Thermal studies show the presence of coordinated water and acetate molecules in the coordination. The powder X-ray diffractogram and SEM pictograph imply that all the complexes have fine crystalline peaks with homogeneous surface morphology. In vitro antimicrobial and antioxidant studies indicate the complexes are more active than free 2-aminobenzamide ligand. The Ni(II)-2AB-gly/phe complexes (1a and 1d) show significant oxidative cleavage and DNA binding activities. Moreover, the 3D molecular modeling, analysis of the complexes has also been studied.
authors.affiliation: Division of Chemistry, Faculty of Science and Humanities, Sree Sowdambika College of Engineering, Chettikurichi, Aruppukottai 626 134, Virudhunagar District, Tamil Nadu, India.
authors.forename: Jeyaprakash
authors.initials: J
authors.lastname: Dharmaraja
authors.affiliation: Department of Chemistry, Devanga Arts College (Autonomous), Aruppukottai 626 101, Virudhunagar District, Tamil Nadu, India.
authors.forename: Paramasivam
authors.initials: P
authors.lastname: Subbaraj
authors.affiliation: Department of Chemistry, Devanga Arts College (Autonomous), Aruppukottai 626 101, Virudhunagar District, Tamil Nadu, India. Electronic address: tesakkidurai.dac@gmail.com.
authors.forename: Thirugnanasamy
authors.initials: T
authors.lastname: Esakkidurai
authors.affiliation: Department of Chemistry, Rajas Institute of Technology for Women, Ozhuginaserri, Nagercoil 629 001, Kanyakumari District, Tamil Nadu, India.
authors.forename: Sutha
authors.initials: S
authors.lastname: Shobana
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D004553:Electric Conductivity; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D007700:Kinetics; D008024:Ligands; D060328:Magnetic Phenomena; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009532:Nickel / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D011208:Powders; D013818:Thermogravimetry; D014732:Vibration; D014961:X-Ray Diffraction; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000890:Anti-Infective Agents; D000975:Antioxidants; D008024:Ligands; D011208:Powders; D062367:ortho-Aminobenzoates; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; C000219:anthranilamide
keywords: 2-Aminobenzamide; DNA interactions; Mixed ligand Ni(II) complexes; Molecular modeling; Pharmacological activities; Spectral studies