title: Secondary metabolites from Penicillium corylophilum isolated from damp buildings.
abstract: Indoor exposure to the spores and mycelial fragments of fungi that grow on damp building materials can result in increased non-atopic asthma and upper respiratory disease. The mechanism appears to involve exposure to low doses of fungal metabolites. Penicillium corylophilum is surprisingly common in damp buildings in USA, Canada and western Europe. We examined isolates of P. corylophilum geographically distributed across Canada in the first comprehensive study of secondary metabolites of this fungus. The sesquiterpene phomenone, the meroterpenoids citreohybridonol and andrastin A, koninginin A, E and G, three new alpha pyrones and four new isochromans were identified from extracts of culture filtrates. This is the first report of koninginins, meroterpenoids and alpha pyrones from P. corylophilum. These secondary metabolite data support the removal of P. corylophilum from Penicillium section Citrina and suggest that further taxonomic studies are required on this species.
authors.affiliation: Ottawa Carleton Institute of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6 Canada.
authors.forename: David R
authors.initials: DR
authors.lastname: McMullin
authors.affiliation: Ottawa Carleton Institute of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6 Canada.
authors.forename: Tienabe K
authors.initials: TK
authors.lastname: Nsiama
authors.affiliation: Ottawa Carleton Institute of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6 Canada david_miller@carleton.ca.
authors.forename: J David
authors.initials: JD
authors.lastname: Miller
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000730:Androstadienes / Q000737:chemistry / Q000302:isolation & purification; D001249:Asthma / Q000382:microbiology*; D002170:Canada; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification; D004781:Environmental Exposure; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification; D006798:Housing; D006813:Humidity; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification*; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification; D010407:Penicillium / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000382:microbiology*; D064210:Secondary Metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000730:Androstadienes; D002839:Chromans; D006575:Heterocyclic Compounds, 3-Ring; D009183:Mycotoxins; D009284:Naphthols; D011753:Pyrones; D012717:Sesquiterpenes; D013729:Terpenes; C100395:andrastin A; C472987:koninginin A; C016657:phomenone
keywords: alpha pyrone; indoor environment; isochroman; koninginin; meroterpenoid