title: Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big?
abstract: While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Aimee L
authors.initials: AL
authors.lastname: Jalkanen
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Coleman
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: jeffrey.wilusz@colostate.edu.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wilusz
mesh_terms: D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D006801:Humans; D026723:Polyadenylation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger
keywords: Deadenylation; Hyperadenylation; Poly(A) tail; Polyadenylation; mRNA 3′ end processing