title: [Hyperhomocysteinemia and cardiovascular risk profile in ischemic heart disease and acid peptic disease comorbidity patients].
abstract: Present article is devoted to the study of the clinic features of ischemic heart desease associated with acid peptic disease. It was shown the more evident increase of myocardial infarction risk in associated pathology patients. Such results have to be caused by the special risk factor. As such factor we desided to study the hyperhomosysteinemia. During research there were discovered that the lowest vitamin B12 serum level and the highest homocysteine serum level have been registrated in associated pathology (ischemic heart disease and acid peptic disease according to long-term proton pump inhibitor use) patients. It was shown evident correlation between that changes and dyslipidemia.
authors.forename: A V
authors.initials: AV
authors.lastname: Zharkova
authors.forename: V F
authors.initials: VF
authors.lastname: Orlovs'kyĭ
mesh_terms: D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005764:Gastroesophageal Reflux / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D010437:Peptic Ulcer / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D054328:Proton Pump Inhibitors; D014280:Triglycerides; D006710:Homocysteine; D002784:Cholesterol; D014805:Vitamin B 12