title: Is glycated hemoglobin related to other dysmetabolic variables implicated in the increase of cardiovascular risk in polycystic ovary syndrome? A comparative study.
abstract: BACKGROUND
  In non-PCOS patients the concentration of glycated hemoglobin (HbA1C) has been employed to identify individuals at higher risk for impaired glucose tolerance (IGT) and diabetes mellitus. A few studies have examined the role of HbA1C in PCOS patients and current results are controversial.
  
  
  OBJECTIVE
  To compare the strength of the association between glycated hemoglobin and other predictors of cardiovascular risk in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This cross-sectional study enrolled 197 PCOS patients and 72 non-PCOS women. Transvaginal ultrasound, biochemical and hormone measurement were performed. Glycated hemoglobin (HbA1C) was correlated with other variables related to dysmetabolic/vascular diseases.
  
  
  RESULTS
  The HbA1C levels were 6.0±1.4% and 4.9±0.4% in PCOS patients and non-PCOS controls, respectively (p<0.001). The HbA1C levels were≥5.7% in 46.4% of PCOS and in none of the control subjects (OR=90.8). HbA1C was well-correlated with several anthropometric, metabolic and endocrine parameters. Stepwise multiple regression including HbA1C and other known predictors of cardiovascular risk resulted in a significant model in which body mass index (BMI) and free testosterone exhibited the best correlation with HbA1C (adjusted R(2)=0.530; F=39.8; p<0.001).
  
  
  CONCLUSIONS
  HbA1C was elevated and correlated with anthropometric, biochemical and endocrine variables of metabolic/vascular disease risks in PCOS patients. Combined HbA1C, BMI and free testosterone levels provided a significant model with potential use to evaluate metabolic/vascular disease in PCOS patients.
authors.affiliation: Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso - Cuiabá, MT, Brazil.
authors.forename: S F
authors.initials: SF
authors.lastname: de Medeiros
authors.affiliation: Tropical Institute of Reproductive Medicine and Menopause - Cuiabá, MT, Brazil.
authors.forename: J S
authors.initials: JS
authors.lastname: Barbosa
authors.affiliation: Tropical Institute of Reproductive Medicine and Menopause - Cuiabá, MT, Brazil.
authors.forename: M A S
authors.initials: MA
authors.lastname: de Medeiros
authors.affiliation: Tropical Institute of Reproductive Medicine and Menopause - Cuiabá, MT, Brazil.
authors.forename: E B
authors.initials: EB
authors.lastname: da Silva
authors.affiliation: Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso - Cuiabá, MT, Brazil.
authors.forename: A C M C
authors.initials: AC
authors.lastname: de Souza
authors.affiliation: Tropical Institute of Reproductive Medicine and Menopause - Cuiabá, MT, Brazil.
authors.forename: M M W
authors.initials: MM
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D015992:Body Mass Index; D018592:Cross-Over Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications*; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D014652:Vascular Diseases / Q000097:blood* / Q000209:etiology*
chemical_list: D006442:Glycated Hemoglobin; D013739:Testosterone; C517652:hemoglobin A1c protein, human