title: Effect of erythropoietin on free radical oxidation and glycoprotein expression in platelets under conditions of chronic renal failure.
abstract: A short-term open prospective study examined 62 patients at the terminal stage of chronic renal failure. The experimental group received erythropoietin in a total dose of about 40,000 U. The expression of glycoproteins IIb-IIIa, IIb, and Ib was enhanced, the content of LPO products was elevated, and SOD and catalase activities were reduced in platelets from patients with chronic renal failure. Administration of erythropoietin partially restored free radical oxidation and expression of glycoproteins IIb-IIIa, IIb, and Ib in platelets. A significant correlation was revealed between the expression of platelet receptors on the one hand, and content of LPO products and SOD and catalase activities, on the other hand.
authors.affiliation: Department of Phatological Phisiology, Chelyabinsk State Medical Academy, Ministry of Health of the Russian Federation, Chelyabinsk, Russia, mvo2003@list.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Osikov
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002374:Catalase / Q000097:blood; D004334:Drug Administration Schedule; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005609:Free Radicals / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D040201:Platelet Membrane Glycoprotein IIb / Q000235:genetics / Q000378:metabolism; D011446:Prospective Studies; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D005609:Free Radicals; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D040201:Platelet Membrane Glycoprotein IIb; D004921:Erythropoietin; D002374:Catalase; D013482:Superoxide Dismutase