title: Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands.
abstract: The exclusive distribution of 5-HT6 receptors in the brain regions associated with learning and memory makes it an ideal target for cognitive disorders. A novel series of 5-piperazinyl methyl-N 1-aryl sulfonyl indoles were designed and synthesized as 5-HT6R ligands. Most of the synthesized compounds are potent when tested by in vitro radioligand binding assay. The lead compound from the series does not have the CYP liabilities and is active in an animal model of cognition.
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Ramakrishna V S
authors.initials: RV
authors.lastname: Nirogi
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Kothmirkar
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Ramasastri
authors.initials: R
authors.lastname: Kambhampati
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Jagadish Babu
authors.initials: JB
authors.lastname: Konda
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Sobhanadri
authors.initials: S
authors.lastname: Arepalli
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Narasimhareddy G
authors.initials: NG
authors.lastname: Pamuleti
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Amol D
authors.initials: AD
authors.lastname: Deshpande
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Trinathreddy
authors.initials: T
authors.lastname: Bandyala
authors.affiliation: Discovery Research, Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Shinde
authors.affiliation: Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad.
authors.forename: P K
authors.initials: PK
authors.lastname: Dubey
keywords: 5-HT6R; 5-Piperazinyl methyl-N1-aryl sulfonyl indole; Morris water mazes; NORT; PK profile; SAR