title: Fesoterodine prescription fill patterns and evaluation of the YourWay patient support plan for patients with overactive bladder symptoms and physicians.
abstract: BACKGROUND
  Adherence with oral medication for overactive bladder syndrome is suboptimal. To improve adherence, the YourWay plan was developed to assist patients and health care providers in defining treatment expectations and facilitating communication.
  
  
  OBJECTIVE
  To evaluate medication adherence among patients with overactive bladder syndrome enrolled in the YourWay patient support plan, patient adoption of behavioral interventions, patient satisfaction with the plan, and physician experience with the plan.
  
  
  METHODS
  In this 13-week, single-arm, open-label, multicenter, noninterventional study, fesoterodine-naïve patients received a prescription for fesoterodine 4 or 8 mg and a packet including a 14-day fesoterodine sample, educational materials, and progress tracker. Patients registered for the YourWay plan, which included an educational resource kit, interactive voice-response calls, and optional online and mail support. The primary end point was the proportion of patients who filled a prescription for a ≥ 90-day supply of fesoterodine within 90 days of enrollment. Secondary end points were the proportion of patients who filled ≥ 1 prescription and ≥ 2 prescriptions (post hoc), patient evaluation of their experience and satisfaction with the YourWay plan, and differences between prescription fillers and nonfillers in plan adoption and assessment (post hoc). We surveyed an independent sample of physicians to assess their experience with YourWay.
  
  
  RESULTS
  Of 500 study completers, 10.4% filled a prescription for a ≥ 90-day supply of fesoterodine. Of those filling a prescription, 26.2% filled ≥ 1 prescription and among those, 61.0% refilled their prescription at least once. Many behavioral recommendations were adopted by 82% to 94% of patients. Fillers were more likely to take fesoterodine as directed, whereas adoption of behavioral recommendations or plan satisfaction did not differ between fillers and nonfillers. Most patients reported that the plan was informative and feasible to implement, and that they were satisfied with various aspects of the plan. Physicians also reported positive experiences.
  
  
  CONCLUSIONS
  Most patients adopted YourWay components and viewed the plan positively, although adherence remained a challenge.
authors.affiliation: Director, Pfizer Global Health and Value, Outcomes and Evidence, Pfizer Inc, New York, NY. jeffrey.trocio@pfizer.com.
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Trocio
authors.forename: Linda
authors.initials: L
authors.lastname: Brubaker
authors.forename: Vernon F
authors.initials: VF
authors.lastname: Schabert
authors.forename: Tamara
authors.initials: T
authors.lastname: Bavendam
authors.forename: Chieh-I
authors.initials: CI
authors.lastname: Chen
authors.forename: Kelly H
authors.initials: KH
authors.lastname: Zou
authors.forename: Allison A
authors.initials: AA
authors.lastname: Petrilla
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Burgio
mesh_terms: D000368:Aged; D001291:Attitude of Health Personnel; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D004363:Drug Utilization; D006801:Humans; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D017060:Patient Satisfaction; D010820:Physicians; D010818:Practice Patterns, Physicians'; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*; D064804:Urological Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016903:Drug Monitoring
chemical_list: D001559:Benzhydryl Compounds; D064804:Urological Agents; C526675:fesoterodine