title: Radiation-enhanced cell migration/invasion process: a review.
abstract: Radiation therapy is a keystone treatment in cancer. Photon radiation has proved its benefits in overall survival in many clinical studies. However, some patients present local recurrences or metastases when cancer cells survive to treatment. Metastasis is a process which includes adhesion of the cell to the extracellular matrix, degradation of the matrix by proteases, cell motility, intravasation in blood or lymphatic vessels, extravasation in distant parenchyma and development of cell colonies. Several studies demonstrated that ionizing radiation might promote migration and invasion of tumor cells by intricate implications in the micro-environment, cell-cell junctions, extracellular matrix junctions, proteases secretion, and induction of epithelial-mesenchymal transition. This review reports various cellular pathways involved in the photon-enhanced cell invasion process for which potential therapeutic target may be employed for enhancing antitumor effectiveness. Understanding these mechanisms could lead to therapeutic strategies to counter the highly invasive cell lines via specific inhibitors or carbon-ion therapy.
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France; Department of Radiotherapy, Institut de Cancérologie de la Lucien Neuwirth, St Priest en Jarez, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Moncharmont
authors.affiliation: Department of Radiotherapy, GustaveRoussy, Villejuif, France.
authors.forename: Antonin
authors.initials: A
authors.lastname: Levy
authors.affiliation: Department of Radiotherapy, Institut de Cancérologie de la Lucien Neuwirth, St Priest en Jarez, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Department of Radiotherapy, Centre Antoine Lacassagne, Nice, France.
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Falk
authors.affiliation: INSERM U908, Growth Factor Signalling in Breast Cancer, Functional Proteomics, University Lille 1, IFR-147, 59000 Villeneuve d'Ascq, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Guilbert
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France.
authors.forename: Jane-Chloé
authors.initials: JC
authors.lastname: Trone
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France.
authors.forename: Gersende
authors.initials: G
authors.lastname: Alphonse
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Gilormini
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Ardail
authors.affiliation: INSERM U908, Growth Factor Signalling in Breast Cancer, Functional Proteomics, University Lille 1, IFR-147, 59000 Villeneuve d'Ascq, France.
authors.forename: Robert-Alain
authors.initials: RA
authors.lastname: Toillon
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Rodriguez-Lafrasse
authors.affiliation: Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France; Department of Radiotherapy, Institut de Cancérologie de la Lucien Neuwirth, St Priest en Jarez, France. Electronic address: nicolas.magne@icloire.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D002465:Cell Movement / Q000528:radiation effects*; D058750:Epithelial-Mesenchymal Transition / Q000528:radiation effects*; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000532:radiotherapy; D009369:Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D011839:Radiation, Ionizing
keywords: Carbon ion; Cell invasion; Epithelial–mesenchymal transition; Radiation-enhanced; Stroma