title: Drinking of flavored solutions by high preferring (WHP) and low preferring (WLP) alcohol-drinking rats.
abstract: BACKGROUND
  Selective breeding alcohol-preferring (P) and alcohol-nonpreferring (NP) rats showed a strong preference for the sucrose solutions, whereas P rats intake greater amounts than NP rats. The aim of this study was the estimation of selectively bred ethanol-preferring (WHP - Warsaw High Preferring) and ethanol-nonpreferring (WLP - Warsaw Low Preferring) rats for their preference for various tastes.
  
  
  METHODS
  The oral drinking of the following substances was studied at a range of concentrations: sucrose (0.5-64.0 g/100 ml), NaCl (0.025-3.2 g/100 ml), citric acid (0.008-2.048 g/l), and sucrose octaacetate (0.002-0.512 g/l) solutions. Separate groups of 7-8 rats from each line were investigated of each of the four tastes. The investigated solutions were presented continuously keeping water and food always available. Concentrations of the various flavors were doubled every 48 h.
  
  
  RESULTS
  Rats from WHP and WLP lines clearly revealed the preference for the sucrose solution and the highest preference was at the 4.0 and 8.0 g/100ml sucrose concentration. Similar to sucrose, both lines exposed strong preference for the NaCl solution and this preference enhanced together with the increase of the NaCl concentration. Nevertheless their preference for the NaCl solutions decreased when the concentration of NaCl reached 1.600 g/100 ml. Both lines of rats did not differ in citric acid or sucrose octaacetate intake at any of the concentrations studied.
  
  
  CONCLUSIONS
  Selective breeding of rats (WHP) for high and rats (WLP) for low ethanol drinking is favorably correlated with the drinking of sweet and salty solutions and negatively correlated with the consumption of sour and bitter tastes.
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute Psychiatry and Neurology, Warszawa, Poland. Electronic address: wdyr@ipin.edu.pl.
authors.forename: Wanda
authors.initials: W
authors.lastname: Dyr
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute Psychiatry and Neurology, Warszawa, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Wyszogrodzka
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute Psychiatry and Neurology, Warszawa, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Mierzejewski
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute Psychiatry and Neurology, Warszawa, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Bieńkowski
mesh_terms: D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D019343:Citric Acid; D004326:Drinking; D005260:Female; D005518:Food Preferences; D051381:Rats; D012965:Sodium Chloride; D013395:Sucrose; D050916:TRPV Cation Channels / Q000502:physiology
chemical_list: D050916:TRPV Cation Channels; C493922:Trpv1 protein, rat; D019343:Citric Acid; D012965:Sodium Chloride; D013395:Sucrose
keywords: Alcohol-nonpreferring WLP rats; Alcohol-preferring WHP rats; Tastes preference