title: Pregnane-type steroids from the Formosan soft coral Scleronephthya flexilis.
abstract: Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan. recall04729@hotmail.com.
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Kuo
authors.affiliation: Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan. juanuro@gmail.com.
authors.forename: Yung-Shun
authors.initials: YS
authors.lastname: Juan
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan. jinx6609@nmmba.gov.tw.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan. michael@mail.nsysu.edu.tw.
authors.forename: Michael Yen-Nan
authors.initials: MY
authors.lastname: Chiang
authors.affiliation: Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan. corallab@ntu.edu.tw.
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.affiliation: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D011278:Pregnanes; D013256:Steroids