title: Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice.
abstract: The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.
authors.affiliation: National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM.
authors.forename: Soumik
authors.initials: S
authors.lastname: Barman
authors.forename: Hemanta
authors.initials: H
authors.lastname: Koley
authors.forename: Dhrubajyoti
authors.initials: D
authors.lastname: Nag
authors.forename: Sumio
authors.initials: S
authors.lastname: Shinoda
authors.forename: Gopinath Balakrish
authors.initials: GB
authors.lastname: Nair
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000907:Antibodies, Bacterial / Q000276:immunology; D004405:Dysentery, Bacillary / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D008297:Male; D051379:Mice; D065288:Serogroup; D012760:Shigella / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000276:immunology*; D022281:Shigella Vaccines / Q000008:administration & dosage / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022281:Shigella Vaccines; D015164:Vaccines, Inactivated
keywords: Shigella vaccine; heat-killed Shigellae; multivalent Shigella immunogen; passive immunity