title: Getting pumped about heart failure.
abstract: Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.
authors.affiliation: Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: dmann@dom.wustl.edu.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000037:antagonists & inhibitors*; D009200:Myocardial Contraction / Q000187:drug effects*
chemical_list: D035683:MicroRNAs