title: Association of serum omentin-1 concentrations with the presence and severity of preeclampsia.
abstract: BACKGROUND
  Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia.
  
  
  METHODS
  Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method.
  
  
  RESULTS
  Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P < 0.001), systolic blood pressure (P < 0.05) and homeostasis model assessment of insulin resistance (P < 0.001).
  
  
  CONCLUSIONS
  Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.
authors.affiliation: Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Liu
authors.affiliation: The Second Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wu
authors.affiliation: Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China.
authors.forename: Lianbing
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Tang
authors.affiliation: Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China schuhty@126.com.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Hao
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D016014:Linear Models; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: Omentin-1; inflammation; preeclampsia