title: Experimental study of the efficiency of Dietressa preparation on body weight reduction in mice feeding high-fat ration.
abstract: We studied the efficiency of Dietressa on body weight reduction in C57Bl/6 male mice feeding standard high-fat ration (24%). After 5-month daily intragastric administration of Dietressa, body weight gain was the lowest in comparison with other groups and did not differ from that in mice receiving the reference substance sibutramine for 5 months. In contrast to sibutramine, Dietressa did not increase motor activity of animals in the open field test and produced no anorectic effect. The mean body weight gain per each 1000 kcal of consumed food in the group of animals receiving Dietressa was lower than in the control group and mice receiving sibutramine.
authors.affiliation: Materia Medica Holding, Moscow, Russia, guryanovann@materiamedica.ru.
authors.forename: N N
authors.initials: NN
authors.lastname: Gur'yanova
authors.forename: L I
authors.initials: LI
authors.lastname: Bugaeva
authors.forename: S A
authors.initials: SA
authors.lastname: Lebedeva
authors.forename: T V
authors.initials: TV
authors.lastname: Tekutova
authors.forename: Yu L
authors.initials: YL
authors.lastname: Dugina
authors.forename: V I
authors.initials: VI
authors.lastname: Petrov
authors.forename: O I
authors.initials: OI
authors.lastname: Epshtein
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D000906:Antibodies / Q000494:pharmacology*; D001067:Appetite Depressants / Q000494:pharmacology; D063387:Cannabinoid Receptor Antagonists / Q000494:pharmacology*; D003503:Cyclobutanes / Q000494:pharmacology; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000009:adverse effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D000906:Antibodies; D001067:Appetite Depressants; D063387:Cannabinoid Receptor Antagonists; C543264:Cnr1 protein, rat; D003503:Cyclobutanes; D004041:Dietary Fats; D043884:Receptor, Cannabinoid, CB1; C058254:sibutramine