title: LINE-1 of evidence for fetal oocyte attrition by retrotransposon.
abstract: Fetal oocytes in mammals undergo extensive apoptosis during development. In this issue of Developmental Cell, Malki et al. (2014) provide insight into how and why such massive oocyte loss occurs through the demonstration that the expression level of LINE-1 retrotransposon defines the survival threshold and thus viability of fetal oocytes.
authors.affiliation: Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. Electronic address: schuma@frontier.kyoto-u.ac.jp.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Chuma
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology*; D004706:Endodeoxyribonucleases / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000166:cytology*; D020084:Long Interspersed Nucleotide Elements / Q000235:genetics*; D008297:Male; D008540:Meiosis / Q000502:physiology*; D009865:Oocytes / Q000166:cytology*; D010053:Ovary / Q000166:cytology*; D014157:Transcription Factors / Q000502:physiology*; D000099257:Meiotic Recombination Protein SPO11
chemical_list: D004268:DNA-Binding Proteins; D004706:Endodeoxyribonucleases; D014157:Transcription Factors; D000099257:Meiotic Recombination Protein SPO11; C531147:maelstrom protein, mouse