title: Therapeutic strategies in multiple sclerosis: a focus on neuroprotection and repair and relevance to schizophrenia.
abstract: Multiple sclerosis is the leading nontraumatic cause of neurologic disability in young adults. The need to prevent neurodegeneration and promote repair in multiple sclerosis (MS) has gained increasing interest in the last decade leading to the search and development of pharmacological agents and non-pharmacologic strategies able to target not only the inflammatory but also the neurodegenerative component of the disease. This paper will provide an overview of the therapeutics currently employed in MS, with a focus on their potential neuroprotective effects and on the MRI methods employed to detect and monitor in-vivo neuroprotection and repair and the relevance of this information to schizophrenia investigation and treatment.
authors.affiliation: Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA. Electronic address: matilde.inglese@mssm.edu.
authors.forename: Matilde
authors.initials: M
authors.lastname: Inglese
authors.affiliation: Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA; Department of Neuroscience, University "Federico II", Naples, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Petracca
mesh_terms: D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012559:Schizophrenia / Q000628:therapy
chemical_list: D018696:Neuroprotective Agents
keywords: Disease-modifying treatments; Multiple sclerosis; Neuroimaging; Neuroprotection; Repair