title: Coating of electrospun poly(lactic-co-glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model.
abstract: We have investigated the combination effects of bioceramics and poly(lactide-co-glycolide) (PLGA) on bone reconstruction in calvarial critical size defects using a rat model. Willemite (Zn2SiO4) ceramics were prepared and coated on the surface of electrospun fabricated scaffolds. After scaffolds and nanoparticles characterization, osteoconductivity of the construct was analyzed using digital mammography, multislice spiral-computed tomography (MSCT) imaging, and histological analysis. Eight weeks after implantation, no sign of inflammation was observed at the site of the osseous defect. The results showed that the ceramics supported bone regeneration and highest bone reconstruction were observed in willemite-coated PLGA. This suggests that electrospun PLGA nanofibers coated with BG are potential candidate implants for bone tissue engineering applications.
authors.affiliation: Department of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Jamshidi Adegani
authors.forename: Lida
authors.initials: L
authors.lastname: Langroudi
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Ardeshirylajimi
authors.forename: Peyman
authors.initials: P
authors.lastname: Dinarvand
authors.forename: Masumeh
authors.initials: M
authors.lastname: Dodel
authors.forename: Ali
authors.initials: A
authors.lastname: Doostmohammadi
authors.forename: Ali
authors.initials: A
authors.lastname: Rahimian
authors.forename: Parastoo
authors.initials: P
authors.lastname: Zohrabi
authors.forename: Ehsan
authors.initials: E
authors.lastname: Seyedjafari
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D002516:Ceramics / Q000737:chemistry; D004195:Disease Models, Animal; D019344:Lactic Acid / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017207:Rats, Sprague-Dawley; D017640:Silicates / Q000737:chemistry*; D012887:Skull Fractures / Q000628:therapy; D013499:Surface Properties; D013718:Tensile Strength; D023822:Tissue Engineering; D014057:Tomography, X-Ray Computed; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D017640:Silicates; D017967:Zinc Compounds; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C029500:zinc silicate
keywords: bone; calvarial defects; electrospinning; tissue engineering; willemite