title: Anticoagulation for the acute management of ischemic stroke.
abstract: Few prospective studies support the use of anticoagulation during the acute phase of ischemic stroke, though observational data suggest a role in certain populations. Depending on the mechanism of stroke, systemic anticoagulation may prevent recurrent cerebral infarction, but concomitantly carries a risk of hemorrhagic transformation. In this article, we describe a case where anticoagulation shows promise for ischemic stroke and review the evidence that has discredited its use in some circumstances while showing its potential in others.
authors.affiliation: Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Austin A
authors.initials: AA
authors.lastname: Robinson
authors.affiliation: Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Kevin
authors.initials: K
authors.lastname: Ikuta
authors.affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Soverow
mesh_terms: D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D012008:Recurrence; D020521:Stroke / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000925:Anticoagulants
keywords: anticoagulation; cardioembolism; hemorrhagic transformation; intracardiac thrombus; ischemic stroke; left ventricular thrombus