title: Effects of fullerenol C₆₀(OH)₂₄ on erythropoiesis in vitro.
abstract: The effects of fullerenol C60(OH)24 in doses of 0.1-100 μg/ml on erythropoiesis were studied in the culture of erythroblastic islets of the bone marrow. Fullerenol in concentrations of 10 and 100 μg/ml had negative effects on the development of erythroid tissue: it inhibits proliferation of erythroid cells, delays erythroblast maturation, decelerates recruitment of erythroid CFU to differentiation, and suppresses repeated involvement of macrophages in erythroblastic islets.
authors.affiliation: Chelyabinsk State Medical Academy, Chelyabinsk, Russia, natalya-tishevskaya@yandex.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Tishevskaya
authors.forename: Yu M
authors.initials: YM
authors.lastname: Zakharov
authors.forename: E V
authors.initials: EV
authors.lastname: Golubotovskii
authors.forename: O L
authors.initials: OL
authors.lastname: Kolesnikov
authors.forename: N V
authors.initials: NV
authors.lastname: Trofimova
authors.forename: Yu V
authors.initials: YV
authors.lastname: Arkhipenko
authors.forename: T G
authors.initials: TG
authors.lastname: Sazontova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001772:Blood Cell Count; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004900:Erythroblasts / Q000166:cytology / Q000187:drug effects*; D041905:Erythroid Cells / Q000166:cytology / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects*; D037741:Fullerenes / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051381:Rats
chemical_list: D037741:Fullerenes; C108127:fullerenol