title: A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis.
abstract: In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
authors.affiliation: School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea. jhpark1@skku.edu.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Shin
authors.forename: Seol-Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Thavasyappan
authors.initials: T
authors.lastname: Thambi
authors.forename: Dong Gil
authors.initials: DG
authors.lastname: You
authors.forename: Jueun
authors.initials: J
authors.lastname: Jeon
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Lee
authors.forename: Bong Youl
authors.initials: BY
authors.lastname: Chung
authors.forename: Dong-Gyu
authors.initials: DG
authors.lastname: Jo
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000378:metabolism; D008727:Methotrexate / Q000008:administration & dosage* / Q000378:metabolism; D051379:Mice
chemical_list: D000276:Adjuvants, Immunologic; D018501:Antirheumatic Agents; D004338:Drug Combinations; D006820:Hyaluronic Acid; D008727:Methotrexate