title: Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids.
abstract: A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.
authors.affiliation: School of Materials Science and Engineering, Department of Chemistry, Shanghai University, Shanghai 200444, China. wanwen@staff.shu.edu.cn jhao@shu.edu.cn.
authors.forename: Guobin
authors.initials: G
authors.lastname: Ma
authors.forename: Wen
authors.initials: W
authors.lastname: Wan
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Hu
authors.forename: Haizhen
authors.initials: H
authors.lastname: Jiang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shizheng
authors.initials: S
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Hao
mesh_terms: D001897:Boronic Acids / Q000737:chemistry* / Q000378:metabolism; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry* / Q000378:metabolism; D008745:Methylation
chemical_list: D001897:Boronic Acids; D006845:Hydrocarbons, Fluorinated; D003300:Copper