title: Catalytic enantioselective iodoaminocyclization of hydrazones.
abstract: The first catalytic enantioselective iodoaminocyclization of β,γ-unsaturated hydrazones has been developed with the help of a trans-1,2-diaminocyclohexane-derived bifunctional thiourea catalyst and allows for the direct access to Δ(2)-pyrazolines containing a quaternary stereogenic center in high yield with good enantioselectivity (up to 95% yield and 95:5 er).
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, India.
authors.forename: Chandra Bhushan
authors.initials: CB
authors.lastname: Tripathi
authors.forename: Santanu
authors.initials: S
authors.lastname: Mukherjee
mesh_terms: D002384:Catalysis; D003514:Cyclohexylamines / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D003514:Cyclohexylamines; D006835:Hydrazones; D006847:Hydrocarbons, Iodinated; D011720:Pyrazoles; C030435:1,2-cyclohexanediamine; D013890:Thiourea