title: Erythropoietin action in stress response, tissue maintenance and metabolism.
abstract: Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinical use in patients with anemia for two and half decades and has facilitated studies of EPO action. Reports of animal and cell models of ischemic stress in vitro and injury suggest potential EPO benefit beyond red blood cell production including vascular endothelial response to increase nitric oxide production, which facilitates oxygen delivery to brain, heart and other non-hematopoietic tissues. This review discusses these and other reports of EPO action beyond red blood cell production, including EPO response affecting metabolism and obesity in animal models. Observations of EPO activity in cell and animal model systems, including mice with tissue specific deletion of EPO receptor (EpoR), suggest the potential for EPO response in metabolism and disease.
authors.affiliation: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. yuanyuan.zhang2@nih.gov.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Faculty of Health Sciences, University of Macau, Macau SAR, China. liwang@umac.mo.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. shoumo.dey@nih.gov.
authors.forename: Soumyadeep
authors.initials: S
authors.lastname: Dey
authors.affiliation: Department of Biological Sciences, Ohio University, Zanesville, OH 43701, USA. al-naeel@ohio.edu.
authors.forename: Mawadda
authors.initials: M
authors.lastname: Alnaeeli
authors.affiliation: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. sukanya.suresh@nih.gov.
authors.forename: Sukanya
authors.initials: S
authors.lastname: Suresh
authors.affiliation: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. heatherro@niddk.nih.gov.
authors.forename: Heather
authors.initials: H
authors.lastname: Rogers
authors.affiliation: Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. tengr@niddk.nih.gov.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Teng
authors.affiliation: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. connien@helix.nih.gov.
authors.forename: Constance Tom
authors.initials: CT
authors.lastname: Noguchi
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D004921:Erythropoietin / Q000378:metabolism*; D050980:GATA Transcription Factors / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D017467:Receptors, Erythropoietin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D050980:GATA Transcription Factors; D051793:Hypoxia-Inducible Factor 1; D017467:Receptors, Erythropoietin; D004921:Erythropoietin; D009569:Nitric Oxide