title: The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction.
abstract: BACKGROUND
  Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigation. We herein genotyped three SNPs (LRP6 rs2302685, LDLRAP1 rs6687605, SOAT1 rs13306731) in lipid metabolism-related genes, aimed to shed light on the influence of these SNPs on individual susceptibility to MI.
  
  
  METHODS
  Genotyping of the three SNPs (rs2302685, rs6687605 and rs13306731) was performed in 285 MI cases and 650 control subjects using polymerase chain reaction-ligation detection reaction (PCR-LDR) method. The association of these SNPs with MI and lipid profiles was performed with SPSS software.
  
  
  RESULTS
  Multivariate logistic regression analysis showed that C allele (OR = 1.62, P = 0.039) and the combined CT/CC genotype (OR = 1.67, P = 0.035) of LRP6 rs2302685 were associated with increased MI risk, while the other two SNPs had no significant effect. Further stratified analysis uncovered a more evident association with MI risk among younger subjects (≤60 years old). Fascinatingly, CT/CC genotype of rs2302685 conferred increased LDL-C levels compared to TT genotype (3.0 mmol/L vs 2.72 mmol/L) in younger subjects.
  
  
  CONCLUSIONS
  Our data provides the first evidence that LRP6 rs2302685 polymorphism is associated with an increased risk of MI in Chinese subjects, and the association is more evident among younger individuals, which probably due to the elevated LDL-C levels.
authors.forename: Shun
authors.initials: S
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.forename: Yu-Ning
authors.initials: YN
authors.lastname: Chen
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
authors.forename: Ze-Wei
authors.initials: ZW
authors.lastname: Ma
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Cen
authors.forename: Xinguang
authors.initials: X
authors.lastname: Liu
authors.forename: Xi-Li
authors.initials: XL
authors.lastname: Yang
authors.forename: Can
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P,R, China. xiongxingdong@126.com.
authors.forename: Xing-Dong
authors.initials: XD
authors.lastname: Xiong
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D060488:Low Density Lipoprotein Receptor-Related Protein-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: C555475:LRP6 protein, human; D060488:Low Density Lipoprotein Receptor-Related Protein-6