title: Transition metal complexes of a new 15-membered [N5] penta-azamacrocyclic ligand with their spectral and anticancer studies.
abstract: Novel penta-azamacrocyclic 15-membered [N5] ligand [L] i.e. 1,5,8,12-tetetraaza-3,4: 9,10-dibenzo-6-ethyl-7-methyl-1,12-(2,6-pyrido)cyclopentadecan-5,7 diene-2,11-dione and its transition metal complexes with Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and structurally characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On basis of IR, MS, UV-Vis 1H NMR and EPR spectral studies an octahedral geometry has been proposed for all complexes except Co(II), Cu(II) nitrate complexes and Pd(II) chloride complex that adopt tetrahedral, square pyramidal and square planar geometries, respectively. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50=2.04-9.7, 2.5-3.7 μg/mL) showed potent antitumor activity comparable with their ligand (IC50=11.7, 3.45 μg/mL) against the above mentioned cell lines, respectively. The results evidently show that the activity of the ligand becomes more pronounced and significant when coordinated to the metal ion.
authors.affiliation: Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt. Electronic address: helboraey@yahoo.com.
authors.forename: Hanaa A
authors.initials: HA
authors.lastname: El-Boraey
authors.affiliation: Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt.
authors.forename: Azza A
authors.initials: AA
authors.lastname: Serag El-Din
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004055:Differential Thermal Analysis; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D056945:Hep G2 Cells; D006801:Humans; D008024:Ligands; D061986:MCF-7 Cells; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D060328:Magnetic Phenomena; D013058:Mass Spectrometry; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D013818:Thermogravimetry; D028561:Transition Elements / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D028561:Transition Elements
keywords: Antitumor activity; IC(50); Macrocyclic metal complexes; Penta-azamacrocyclic; Spectral studies