title: Direct assembly of 2-oxazolidinones by chemical fixation of carbon dioxide.
abstract: The reaction of β- and γ-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations.
authors.affiliation: Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, 00014 Helsinki (Finland), Fax: (+358) 9-191-50198.
authors.forename: Teemu
authors.initials: T
authors.lastname: Niemi
authors.forename: Jesus E
authors.initials: JE
authors.lastname: Perea-Buceta
authors.forename: Israel
authors.initials: I
authors.lastname: Fernández
authors.forename: Sami
authors.initials: S
authors.lastname: Alakurtti
authors.forename: Erika
authors.initials: E
authors.lastname: Rantala
authors.forename: Timo
authors.initials: T
authors.lastname: Repo
keywords: 2-oxazolidones; antibiotics; carbon dioxide activation; carbon dioxide fixation; density functional calculations