title: Carbon nanoparticle-protected aptamers for highly sensitive and selective detection of biomolecules based on nuclease-assisted target recycling signal amplification.
abstract: Based on the protective properties of carbon nanoparticles for aptamers against the digestion of nuclease, we have developed a nuclease-assisted target recycling signal amplification method for highly sensitive detection of biomolecules, such as ATP and kanamycin. The high binding specificity between aptamers and targets leads to excellent selectivity of the assay.
authors.affiliation: The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. zhuzhi@xmu.edu.cn cyyang@xmu.edu.cn.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lin
authors.forename: Liang
authors.initials: L
authors.lastname: Cui
authors.forename: Yishun
authors.initials: Y
authors.lastname: Huang
authors.forename: Ya
authors.initials: Y
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhu
authors.forename: Bincheng
authors.initials: B
authors.lastname: Yin
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Chaoyong James
authors.initials: CJ
authors.lastname: Yang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism; D003851:Deoxyribonucleases / Q000737:chemistry* / Q000378:metabolism; D015253:Deoxyribonucleases, Type I Site-Specific / Q000737:chemistry / Q000378:metabolism; D037742:Nanotubes, Carbon / Q000737:chemistry*; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*
chemical_list: D052157:Aptamers, Nucleotide; D037742:Nanotubes, Carbon; D003851:Deoxyribonucleases; D015253:Deoxyribonucleases, Type I Site-Specific