title: Identification of 32 major histocompatibility complex class I alleles in African green monkeys.
abstract: The African green monkey may be an ideal replacement for the rhesus monkey in biomedical research, but relatively little is known about the genetic background of major histocompatibility complex (MHC) class I molecules. In analysis of 12 African green monkeys, 13 Chae-A and 19 Chae-B alleles were identified. Among these alleles, 12 Chae-A and 9 Chae-B were new lineages. The full amino acid length deduced for Chae-A genes is 365 amino acids, but for Chae-B genes, the lengths are 365, 362, 361, and 359 amino acids, respectively. There were 1-3 Chae-A alleles and 2-5 Chae-B alleles in each animal. In African green monkeys, rhesus monkeys, and cynomolgus monkeys, the MHC-A and MHC-B alleles display trans-species polymorphism, rather than being clustered in a species-specific fashion.
authors.affiliation: Laboratory Animal Center, The Academy of Military Medical Science, Beijing, China; College of Life Sciences, Tarim University, Alaer, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.forename: A
authors.initials: A
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.forename: Y
authors.initials: Y
authors.lastname: Fa
authors.forename: L
authors.initials: L
authors.lastname: Zeng
authors.forename: J
authors.initials: J
authors.lastname: Fan
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002522:Chlorocebus aethiops / Q000235:genetics*; D005787:Gene Frequency; D015395:Histocompatibility Antigens Class I / Q000145:classification* / Q000235:genetics*; D008252:Macaca fascicularis / Q000235:genetics; D008253:Macaca mulatta / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D013045:Species Specificity
chemical_list: D015395:Histocompatibility Antigens Class I
keywords: African green monkeys; alleles; identification; major histocompatibility complex class I