title: [Treatment of pediatric epilepsy].
abstract: Recently, the treatment strategy for pediatric epilepsy has been dramatically changed in Japan, because of the approval of new-generation antiepileptic drugs. Since 2006, a total of 6 new antiepileptic drugs, including gabapentin (GBP; adults/pediatric patients: 2006/2011 [year of approval]), topiramate (TPM; 2007/2013), lamotrigine (LTG; 2008/2008), levetiracetam (LEV; 2010/2013), stiripentol (STP; 2012/2012), and rufinamide (RUF; 2013/2013), have been introduced. Thus far, valproate (VPA) and carbamazepine (CBZ) have been first indicated for "generalized" epilepsy and "focal" epilepsy syndromes/types, respectively, in Japan. However, the approval of these new drugs could allow us to choose more effective and less toxic ones at an early stage of treatment. In this chapter, we describe the latest domestic and foreign guidelines for the treatment of pediatric epilepsy.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ito
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Oguni
mesh_terms: D000293:Adolescent; D000588:Amines; D000927:Anticonvulsants / Q000008:administration & dosage; D002220:Carbamazepine; D002648:Child; D002675:Child, Preschool; D003509:Cyclohexanecarboxylic Acids; D004148:Dioxolanes; D017277:Drug Approval; D057915:Drug Substitution; D004827:Epilepsy / Q000188:drug therapy*; D005632:Fructose / Q000031:analogs & derivatives; D000077206:Gabapentin; D006801:Humans; D007223:Infant; D000077213:Lamotrigine; D000077287:Levetiracetam; D010353:Patient Education as Topic; D010889:Piracetam / Q000031:analogs & derivatives; D017410:Practice Guidelines as Topic; D000077236:Topiramate; D014227:Triazines; D014230:Triazoles; D014635:Valproic Acid; D005680:gamma-Aminobutyric Acid
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D004148:Dioxolanes; D014227:Triazines; D014230:Triazoles; D000077236:Topiramate; D005632:Fructose; D002220:Carbamazepine; D000077287:Levetiracetam; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000077206:Gabapentin; C021092:stiripentol; D000077213:Lamotrigine; C079703:rufinamide; D010889:Piracetam