title: A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage.
abstract: There is no effective treatment for intracerebral hemorrhage (ICH). Intracerebral delivery of nanomaterials into the hemorrhagic lesion may be a new therapeutic strategy. In a rat model of ICH plus ultra-early hematoma aspiration, we found that locally delivered self-assembling peptide nanofiber scaffold (SAPNS) replaced the hematoma, reduced acute brain injury and brain cavity formation, and improved sensorimotor functional recovery. SAPNS serves as biocompatible material in the hemorrhagic brain cavity. Local delivery of this nanomaterial may facilitate the repair of ICH related brain injury and functional recovery. From the clinical editor: In a rat model of intracranial hemorrhage, these authors demonstrate that following ultra-early hematoma aspiration, local delivery of a self-assembling peptide nanofiber scaffold replaces the hematoma, reduces brain cavity formation, and improves sensorimotor functional recovery. Similar approaches would be welcome additions to the clinical treatment of this often devastating condition.
authors.affiliation: Department of Medicine, University of Hong Kong, Hong Kong, China; Department of Anatomy, University of Hong Kong, Hong Kong, China; Department of Surgery, University of Hong Kong, Hong Kong, China.
authors.forename: Lynn Yan-Hua
authors.initials: LY
authors.lastname: Sang
authors.affiliation: Department of Anatomy, University of Hong Kong, Hong Kong, China; State Key Lab of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Liang
authors.affiliation: Department of Neuroscience, the University of WI-Madison, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Anatomy, University of Hong Kong, Hong Kong, China.
authors.forename: Wai-Man
authors.initials: WM
authors.lastname: Wong
authors.affiliation: Department of Anatomy, University of Hong Kong, Hong Kong, China.
authors.forename: David Kiong-Chiu
authors.initials: DK
authors.lastname: Tay
authors.affiliation: Department of Anatomy, University of Hong Kong, Hong Kong, China; State Key Lab of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China; Department of Ophthalmology, University of Hong Kong, Hong Kong, China.
authors.forename: Kwok-Fai
authors.initials: KF
authors.lastname: So
authors.affiliation: Department of Anatomy, University of Hong Kong, Hong Kong, China; State Key Lab of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University, Heidelberg, Germany.
authors.forename: Rutledge G
authors.initials: RG
authors.lastname: Ellis-Behnke
authors.affiliation: Department of Anatomy, University of Hong Kong, Hong Kong, China; State Key Lab of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China; Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
authors.forename: Wutian
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Medicine, University of Hong Kong, Hong Kong, China; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. Electronic address: rtcheung@hku.hk.
authors.forename: Raymond Tak-Fai
authors.initials: RT
authors.lastname: Cheung
mesh_terms: D000208:Acute Disease; D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D020300:Intracranial Hemorrhages / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D057139:Nanofibers / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects*
chemical_list: D010455:Peptides
keywords: In vivo; Intracerebral hemorrhage; Nanomaterial; Rat; Self-assembling peptide nanofiber scaffold