title: A normative theory of forgetting: lessons from the fruit fly.
abstract: Recent experiments revealed that the fruit fly Drosophila melanogaster has a dedicated mechanism for forgetting: blocking the G-protein Rac leads to slower and activating Rac to faster forgetting. This active form of forgetting lacks a satisfactory functional explanation. We investigated optimal decision making for an agent adapting to a stochastic environment where a stimulus may switch between being indicative of reward or punishment. Like Drosophila, an optimal agent shows forgetting with a rate that is linked to the time scale of changes in the environment. Moreover, to reduce the odds of missing future reward, an optimal agent may trade the risk of immediate pain for information gain and thus forget faster after aversive conditioning. A simple neuronal network reproduces these features. Our theory shows that forgetting in Drosophila appears as an optimal adaptive behavior in a changing environment. This is in line with the view that forgetting is adaptive rather than a consequence of limitations of the memory system.
authors.affiliation: Department of Physiology, University of Bern, Bern, Switzerland.
authors.forename: Johanni
authors.initials: J
authors.lastname: Brea
authors.affiliation: Department of Physiology, University of Bern, Bern, Switzerland.
authors.forename: Robert
authors.initials: R
authors.lastname: Urbanczik
authors.affiliation: Department of Physiology and Center for Cognition, Learning and Memory, University of Bern, Bern, Switzerland.
authors.forename: Walter
authors.initials: W
authors.lastname: Senn
mesh_terms: D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D019295:Computational Biology; D003213:Conditioning, Psychological; D003657:Decision Making / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology*; D004777:Environment; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D008960:Models, Psychological; D009812:Odorants; D012201:Reward; D013269:Stochastic Processes