title: An association of elevated levels of alkaline phosphatase and gamma-glutamyl transpeptidase with acute cholangitis.
abstract: OBJECTIVE
  The early diagnosis of acute cholangitis (AC) is critical for appropriate treatment.
  
  
  METHODS
  Patient records from April 2008 to December 2012 were retrospectively analyzed. Data on white blood cell count and levels of C-reactive protein, total-bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (gamma-GTP) were collected from AC patients on the day they underwent endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and treatment. Data were collected 3 months before ERCP to analyze the rate of change of these variables. Receiver operating characteristics curve analysis was performed.
  
  
  RESULTS
  We enrolled 63 patients with AC and 65 patients with non-AC. The threshold values of ALP and gamma-GTP were 1.09 and 1.30, respectively.
  
  
  CONCLUSIONS
  450 (IU/L) and 100 (IU/L), respectively, were thresholds of ALP and gamma-GTP on the day of ERCP. 1.09 and 1.30, respectively, were thresholds of ALP and gamma-GTP rates of change for the diagnosis of AC.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tomizawa
authors.forename: Fuminobu
authors.initials: F
authors.lastname: Shinozaki
authors.forename: Rumiko
authors.initials: R
authors.lastname: Hasegawa
authors.forename: Akira
authors.initials: A
authors.lastname: Togawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Shirai
authors.forename: Noboru
authors.initials: N
authors.lastname: Ichiki
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Motoyoshi
authors.forename: Takao
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Shigenori
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Sueishi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase