title: Interaction between Nm23 and the tumor suppressor VHL.
abstract: Among the anti-tumor genes (tumor suppressors and metastasis suppressors), the von-Hippel Lindau gene and the Nm23 family of genes are among the more intriguing ones. Both are small (long and short forms of VHL are 30 and 19 kD, respectively, and Nm23 is ~17 kD), and both possess diverse molecular and cellular functions. Despite extensive studies, the entire spectra of functions and the molecular function-phenotype correlation of these two proteins have not been completely elucidated. In this report, we present data showing these two proteins interact physically. We also summarize and confirm the previous studies that demonstrated the endocytic function of these two genes and further show that the endocytic function of VHL is mediated through the activity of Nm23. These functional and molecular interactions are evolutionarily conserved from Drosophila to human.
authors.affiliation: Department of Surgery, Cathay General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Vincent
authors.initials: V
authors.lastname: Dammai
authors.forename: Boris
authors.initials: B
authors.lastname: Adryan
authors.forename: Tien
authors.initials: T
authors.lastname: Hsu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018076:DNA, Complementary / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D054778:NM23 Nucleoside Diphosphate Kinases / Q000235:genetics / Q000378:metabolism*; D009701:Nucleoside-Diphosphate Kinase / Q000235:genetics / Q000378:metabolism*; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000378:metabolism; D020798:Two-Hybrid System Techniques; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D018076:DNA, Complementary; D029721:Drosophila Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1; D009701:Nucleoside-Diphosphate Kinase; C061642:awd protein, Drosophila