title: Easy access to Evans' oxazolidinones. Stereoselective synthesis and antibacterial activity of a new 2-oxazolidinone derivative.
abstract: An interesting new approach was developed for the synthesis of Evans' chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte-MG 31270-901, Brazil. gaspardm@qui.ufmg.br.
authors.forename: Gaspar
authors.initials: G
authors.lastname: Diaz
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte-MG 31270-901, Brazil. adrianeamantea@gmail.com.
authors.forename: Michelle A A
authors.initials: MA
authors.lastname: de Freitas
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa-MG 36570-000, Brazil.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Ricci-Silva
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa-MG 36570-000, Brazil. marisanogueira@ufv.br.
authors.forename: Marisa A N
authors.initials: MA
authors.lastname: Diaz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D008414:Mastitis, Bovine / Q000382:microbiology; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones