title: Anti-Mullerian hormone and insulin resistance in polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a prevalent disease affecting women of reproductive age. It may be associated with metabolic disorders such as insulin resistance (IR) and obesity. The anti-Mullerian hormone (AMH) levels seem to be higher in patients with PCOS.
  
  
  OBJECTIVE
  The present study was designed to evaluate the association between AMH and insulin in women with PCOS with and without IR.
  
  
  METHODS
  Cross-sectional study, including 86 patients, selected and divided into three groups: Group A: 26 women with PCOS and IR; Group B: 30 women with PCOS and without IR; and Group C: 30 controls without PCOS.
  
  
  RESULTS
  We found significant difference between serum AMH levels in the group of women with PCOS and without IR when compared to the control group, thus showing that PCOS and IR play an important role in elevating the levels of this hormone. When the groups were compared with each other following adjustment for BMI, serum AMH levels were significantly higher in the group of women with PCOS and IR.
  
  
  CONCLUSIONS
  AMH levels are significantly higher in patients with PCOS, particularly in those women with PCOS and IR. Nevertheless, larger samples are required to confirm these findings.
authors.affiliation: Departament of Obstetrics and Gynecology , Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo , Brazil .
authors.forename: Helena Proni
authors.initials: HP
authors.lastname: Fonseca
authors.forename: Renata Suzuki
authors.initials: RS
authors.lastname: Brondi
authors.forename: Fernanda Xavier
authors.initials: FX
authors.lastname: Piovesan
authors.forename: Thomas Gabriel
authors.initials: TG
authors.lastname: Miklos
authors.forename: José Mendes
authors.initials: JM
authors.lastname: Aldrighi
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D000728:Androgens; D007328:Insulin; D054304:Anti-Mullerian Hormone
keywords: Androgens; anovulation; anti-Mullerian hormone; body mass index; folliculogenesis; insulin resistance; polycystic ovary syndrome