title: Evolution of the patient characteristics of candidates for radical prostatectomy and the results obtained with the technique.
abstract: OBJECTIVE
  To evaluate the oncological profile and risk of biochemical recurrence of patients with prostate cancer who underwent radical prostatectomy based on the time period in which the patients were operated. To evaluate the differences in prostate-specific antigen (PSA) at diagnosis of patients with or without biochemical recurrence based on these time periods.
  
  
  METHODS
  Observation carried forward study of a cohort of 972 radical prostatectomies performed during 3 time periods (1994-2000, 2001-2006, 2007-2011). The importance of PSA at diagnosis on the time periods and on biochemical recurrence was assessed using a generalized linear model. The independent predictive behavior of biochemical recurrence was analyzed using Cox regression.
  
  
  RESULTS
  The median follow-up was 38 (16-76) months. PSA levels at diagnosis were higher in the period 1994-2000 (12.97ng/mL, P<.001). Seventy-two percent of the patients from the period 2007-2011 were diagnosed as clinical stage T1c (P<.001), compared with 55% from the period 1994-2000. The percentage of extracapsular extension in the specimen decreased from 27% to 18% from the period 1994-2000 to the period 2007-2011 (p<.001). The percentage of patients with biochemical recurrence went from 38% to 14% from the first to the third period (P>.001). The difference between PSA levels at diagnosis for the patients with or without biochemical recurrence was independent of the period (P=.84). The period during which surgery was performed was not an independent predictive factor for biochemical recurrence (P=.09).
  
  
  CONCLUSIONS
  Patients from the 2007-2011 period had less extracapsular disease in the radical prostatectomy. The period was not an independent predictive factor for biochemical recurrence.
authors.affiliation: Servicio de Urología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España. Electronic address: asanchisbonet@yahoo.es.
authors.forename: A
authors.initials: A
authors.lastname: Sanchís-Bonet
authors.affiliation: Servicio de Urología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España; Fundación para la Investigación Biomédica del Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Arribas-Gómez
authors.affiliation: Servicio de Urología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Sánchez-Rodríguez
authors.affiliation: Servicio de Urología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Chapado
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen
keywords: Antígeno prostático específico; Biochemical recurrence; Diagnosis; Diagnóstico; Estadificación; Prostate Specific Antigen; Prostatectomía radical; Radical prostatectomy; Recidiva bioquímica; Staging