title: No association between typical European mitochondrial variation and prostate cancer risk in a Spanish cohort.
abstract: Mitochondrial common variants (mtSNPs) and the haplogroups defined by them have been inconsistently correlated with increased prostate cancer risk. Here we aimed to investigate the influence of the mitochondrial genetic background on prostate cancer. A total of 15 single-nucleotide polymorphisms (SNPs) representing the common European branches of the mtDNA phylogeny were analyzed in a cohort of 620 Spanish prostate cancer patients and 616 matched population-based controls. Association tests were computed on mtSNPs and haplogroups. None of the evaluated mtSNPs or haplogroups were statistically associated with prostate cancer risk in our Spanish cohort. We show that previous association findings do not rest on solid grounds given that all of them (i) were based on underpowered studies, (ii) did not control for population stratification, (iii) lacked replication/confirmation cohorts, and (iv) and did not control for multiple test corrections. Taken together, a critical reassessment of the previous literature and the results obtained in the present study suggest that mtDNA common European variants are not correlated with increases in the risk for prostate cancer.
authors.affiliation: Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Fachal
authors.affiliation: Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gómez-Caamaño
authors.affiliation: Unidade de Xenética, Facultade de Medicina, Departamento de Anatomía Patolóxica e Ciencias Forenses, Instituto de Ciencias Forenses, Universidade de Santiago de Compostela, Galicia, Spain.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Alvarez Iglesias
authors.affiliation: Unidade de Xenética, Facultade de Medicina, Departamento de Anatomía Patolóxica e Ciencias Forenses, Instituto de Ciencias Forenses, Universidade de Santiago de Compostela, Galicia, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gómez Carballa
authors.affiliation: Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Calvo
authors.affiliation: Unidade de Xenética, Facultade de Medicina, Departamento de Anatomía Patolóxica e Ciencias Forenses, Instituto de Ciencias Forenses, Universidade de Santiago de Compostela, Galicia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Salas
authors.affiliation: Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Vega
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D004272:DNA, Mitochondrial; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D013030:Spain; D044465:White People / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial