title: Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
abstract: BACKGROUND
  Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling. Trophoblast and tumor cells have similar invasion mechanism. Prostasin is closely related to tumor development, invasion and metastasis and influences blood pressure through activating epithelial sodium channel. The effect of prostasin on the pathogenesis of preeclampsia remains unclear. This study investigated the association of prostasin gene at rs12597511 with severe preeclampsia.
  
  
  METHODS
  A single nucleotide polymorphism, rs12597511, was tested with polymerase chain reaction and restrictionfragment length polymorphism analyses in 179 severe preeclampsia patients and 222 normal pregnant women.
  
  
  RESULTS
  The frequencies of TC + CC genotypes were significantly higher in severe preeclampsia group compared with in control group (the adjusted odds ratio was 2.030, 95% confidence interval 1.195-3.449, P = 0.009). The C allele of rs12597511 was present significantly more often among women with severe preeclampsia (P = 0.001). Genotyping analysis showed that the C allele of rs12597511 could confer a risk for severe preeclampsia.
  
  
  CONCLUSIONS
  The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Luo
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Xijing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Gong
authors.affiliation: West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Linli
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Email: zhourong_hx@scu.edu.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012697:Serine Endopeptidases / Q000235:genetics*; D055815:Young Adult; D000099271:Prostasin
chemical_list: D012697:Serine Endopeptidases; D000099271:Prostasin