title: Hemodynamic impact of cerebral aneurysm endovascular treatment devices: coils and flow diverters.
abstract: Coils and flow diverters or stents are devices successfully used to treat cerebral aneurysms. Treatment aims to reduce intra-aneurysmal flow, thereby separating the aneurysmal sac from the blood circulation. The focus and this manuscript combining literature review and our original research is an analysis of changes in aneurysmal hemodynamics caused by endovascular treatment devices. Knowledge of post-treatment hemodynamics is a path to successful long-term treatment. Summarizing findings on hemodynamic impact of treatment devices, we conclude: coiling and stenting do not affect post-treatment intra-aneurysmal pressure, but significantly alter aneurysmal hemodynamics through flow reduction and a change in flow structure. The impact of treatment devices on aneurysmal flow depends, however, on a set of parameters including device geometry, course of placement, parent vessel and aneurysm geometry.
authors.affiliation: Biofluid Mechanics Laboratory, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: Leonid
authors.initials: L
authors.lastname: Goubergrits
authors.forename: Jens
authors.initials: J
authors.lastname: Schaller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kertzscher
authors.forename: Thies
authors.initials: T
authors.lastname: Woelken
authors.forename: Moritz
authors.initials: M
authors.lastname: Ringelstein
authors.forename: Andreas
authors.initials: A
authors.lastname: Spuler
mesh_terms: D000818:Animals; D057510:Endovascular Procedures / Q000295:instrumentation*; D004864:Equipment and Supplies; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000601:surgery*
keywords: cerebral aneurysms; coils; computational fluid dynamics; endovascular treatment; flow diverters; flow visualization; stents; wall shear stress