title: Maternal immunity enhances Mycoplasma hyopneumoniae vaccination induced cell-mediated immune responses in piglets.
abstract: BACKGROUND
  Passively acquired maternal derived immunity (MDI) is a double-edged sword. Maternal derived antibody-mediated immunity (AMI) and cell-mediated immunity (CMI) are critical immediate defenses for the neonate; however, MDI may interfere with the induction of active immunity in the neonate, i.e. passive interference. The effect of antigen-specific MDI on vaccine-induced AMI and CMI responses to Mycoplasma hyopneumoniae (M. hyopneumoniae) was assessed in neonatal piglets. To determine whether CMI and AMI responses could be induced in piglets with MDI, piglets with high and low levels of maternal M. hyopneumoniae-specific immunity were vaccinated against M. hyopneumoniae at 7 d of age. Piglet M. hyopneumoniae-specific antibody, lymphoproliferation, and delayed type hypersensitivity (DTH) responses were measured 7 d and 14 d post vaccination.
  
  
  RESULTS
  Piglets with M. hyopneumoniae-specific MDI failed to show vaccine-induced AMI responses; there was no rise in M. hyopneumoniae antibody levels following vaccination of piglets in the presence of M. hyopneumoniae-specific MDI. However, piglets with M. hyopneumoniae-specific MDI had primary (antigen-specific lymphoproliferation) and secondary (DTH) M. hyopneumoniae-specific CMI responses following vaccination.
  
  
  CONCLUSIONS
  In this study neonatal M. hyopneumoniae-specific CMI was not subject to passive interference by MDI. Further, it appears that both maternal derived and endogenous CMI contribute to M. hyopneumoniae-specific CMI responses in piglets vaccinated in the face of MDI.
authors.forename: Meggan
authors.initials: M
authors.lastname: Bandrick
authors.forename: Kara
authors.initials: K
authors.lastname: Theis
authors.affiliation: Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Ave, St, Paul, MN 55108, USA. molit001@umn.edu.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Molitor
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001428:Bacterial Vaccines / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular / Q000502:physiology; D007112:Immunity, Maternally-Acquired; D045705:Mycoplasma hyopneumoniae / Q000276:immunology*; D045729:Pneumonia of Swine, Mycoplasmal / Q000276:immunology / Q000517:prevention & control*; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines