title: Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts.
abstract: This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.
authors.affiliation: Radboud University Medical Center, Department of Psychiatry, PO Box 9101, 6500 HB Nijmegen, The Netherlands; Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: cpmveth@gmail.com.
authors.forename: Cornelis P M
authors.initials: CP
authors.lastname: Veth
authors.affiliation: Research Institute Brainclinics, Bijleveldsingel 34, 6524 AD Nijmegen, The Netherlands; Utrecht University, Department of Experimental Psychology, Utrecht, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: Arns
authors.affiliation: Janssen Research and Development, Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium.
authors.forename: Wilhelmus
authors.initials: W
authors.lastname: Drinkenburg
authors.affiliation: Janssen Research and Development, Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium.
authors.forename: Willem
authors.initials: W
authors.lastname: Talloen
authors.affiliation: Janssen Research and Development, Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium.
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: Peeters
authors.affiliation: Brain Resource Limited, Level 12, 235 Jones St. Ultimo, NSW 2007, Australia.
authors.forename: Evian
authors.initials: E
authors.lastname: Gordon
authors.affiliation: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Jan K
authors.initials: JK
authors.lastname: Buitelaar
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001315:Australia; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D015331:Cohort Studies; D003863:Depression / Q000188:drug therapy / Q000235:genetics*; D004569:Electroencephalography / Q000379:methods*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017397:Prefrontal Cortex / Q000187:drug effects; D014633:Valine / Q000235:genetics
chemical_list: D000928:Antidepressive Agents; D008715:Methionine; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D014633:Valine
keywords: Catechol-O-Methyltransferase Val158Met polymorphism; Electroencephalographic alpha peak frequency; Major depressive disorder