title: Interaction of parental KIR and fetal HLA-C genotypes with the risk of preeclampsia.
abstract: OBJECTIVE
  The aim of this study is to investigate whether certain combination of maternal killer cell immunoglobulin-like receptors (KIR) and fetal human leukocyte antigen-C (HLA-C) is risk for preeclampsia in the Chinese Han population.
  
  
  METHODS
  A case-control study was conducted in 47 pregnant women with preeclampsia and 54 normal pregnant women. Twelve KIR genes were genotyped by PCR-sequence-specific primer in mothers. High-resolution HLA-C genotyping was performed in couples and fetuses by a routine sequencing-based typing method.
  
  
  RESULTS
  The frequency of KIR2DS1 was decreased (p = 0.028) and AA genotype was increased (p = 0.017) in preeclampsia compared with controls. More women with KIR AA genotype have fewer C2 genes than their fetuses in preeclampsia than controls.
  
  
  CONCLUSIONS
  Women with KIR AA genotype and fewer C2 genes than their fetuses were at risk for preeclampsia in the Chinese Han population, supporting that maternal-fetal KIR-HLA-C interaction plays an important role in preeclampsia development.
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Zhongda Hospital, Medical School, Southeast University , Nanjing, Jiangsu Province , China .
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.forename: Ning
authors.initials: N
authors.lastname: Pan
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Shuo
authors.initials: S
authors.lastname: Jin
authors.forename: Jingli
authors.initials: J
authors.lastname: Zhai
authors.forename: Dongyan
authors.initials: D
authors.lastname: Qiao
authors.forename: Yanting
authors.initials: Y
authors.lastname: Shen
authors.forename: Fengqin
authors.initials: F
authors.lastname: Miao
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.forename: Youji
authors.initials: Y
authors.lastname: He
authors.forename: Mulan
authors.initials: M
authors.lastname: Ren
authors.forename: Jianqiong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D054340:Receptors, KIR / Q000235:genetics*; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; C496212:KIR2DS1 protein, human; D054340:Receptors, KIR
keywords: HLA-C; KIR; preeclampsia