title: Asymmetric synthesis of functionalized dihydronaphthoquinones containing quaternary carbon centers via a metal-free catalytic intramolecular acylcyanation of activated alkenes.
abstract: A novel metal-free catalytic annulation was developed through a Lewis base-catalyzed asymmetric allylic alkylation and the ensuing unprecedented asymmetric intramolecular acylcyanation of alkenes. This protocol provides a unique and facile access to prepare enantioenriched densely functionalized dihydronaphthoquinones accompanied by enantiomerically pure 3,3-disubstituted phthalides bearing quaternary carbon centers.
authors.affiliation: Department of Organic Chemistry, College of Chemistry, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhuang
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Hu
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liao