title: Late-stage formation of carbon-fluorine bonds.
abstract: In this account, we review work from our lab on the development of methods for carbon-fluorine bond formation, with an emphasis on late-stage fluorination of functionalized small molecules and synthesis of (18) F-labeled molecules for potential use as tracers in positron emission tomography (PET). We attempt to highlight reactions that we feel are of particular practical relevance, as well as areas of research where there is still significant room for advancement.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Campbell
authors.forename: Tobias
authors.initials: T
authors.lastname: Ritter
mesh_terms: D002244:Carbon / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry; D054879:Halogenation; D006801:Humans; D010165:Palladium / Q000737:chemistry; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry; D012834:Silver / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D005461:Fluorine; D012834:Silver; D010165:Palladium; D002244:Carbon
keywords: catalysis; fluorine; radiotracer synthesis; transition metals