title: An organocatalytic one-pot cascade incorporating the Achmatowicz reaction affording 3-pyrone derivatives.
abstract: The development of an organocatalytic one-pot cascade for the annulation of simple starting materials: α,β-unsaturated aldehydes, hydrogen peroxide, β-carbonyl compounds and NBS to furnish optically active 3-pyrones in good yield and with excellent enantioselectivity is presented. Further diversification of the obtained products is demonstrated by selective reductive transformations.
authors.affiliation: Center for Catalysis, Department of Chemistry, Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark. kaj@chem.au.dk.
authors.forename: Lars Krogager
authors.initials: LK
authors.lastname: Ransborg
authors.forename: Lennart
authors.initials: L
authors.lastname: Lykke
authors.forename: Niels
authors.initials: N
authors.lastname: Hammer
authors.forename: Line
authors.initials: L
authors.lastname: Næsborg
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D011753:Pyrones / Q000138:chemical synthesis* / Q000378:metabolism*
chemical_list: D011753:Pyrones