title: A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with psoriasis in the Greek population.
abstract: Psoriasis affects 2-3% of the population, causing significant morbidity and financial burden. Immunosuppressive drugs such as cyclosporine are first line systemic therapies for moderate-to-severe forms. However, patients exhibit heterogeneity in their response to therapy, possibly due to genetic factors. The aim of the present study was to assess the ABCB1 T-129C, G1199A, C1236T, G2677T and C3435T single-nucleotide polymorphisms (SNPs) as candidate predictive markers of response to cyclosporine treatment in 84 psoriasis patients. 62% of the patients were defined as responders and 38% as nonresponders. All SNPs complied with Hardy-Weinberg equilibrium. SNP and haplotype analyses were performed to access responsiveness to treatment. Association analysis revealed statistically significant association of SNP 3435 T with negative response (P=0.0075), a result that was further validated in haplotype analysis. This study is the first in the field of the pharmacogenetics of cyclosporine in psoriasis whose results merit further exploitation in larger independent cohorts.
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: Y
authors.initials: Y
authors.lastname: Vasilopoulos
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Sarri
authors.affiliation: Department of Dermatology, University General Hospital Larissa, University of Thessaly, Larissa, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Zafiriou
authors.affiliation: Second Department of Dermatology, School of Medicine, Aristotle University, Papageorgiou Hospital, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Patsatsi
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Stamatis
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Ntoumou
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Fassos
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Tsalta
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Karra
authors.affiliation: Department of Dermatology, University General Hospital Larissa, University of Thessaly, Larissa, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Roussaki-Schulze
authors.affiliation: Second Department of Dermatology, School of Medicine, Aristotle University, Papageorgiou Hospital, Thessaloniki, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Sotiriadis
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: Z
authors.initials: Z
authors.lastname: Mamuris
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Sarafidou
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011565:Psoriasis / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D016572:Cyclosporine