title: Complicated and uncomplicated peptic ulcer disease: altered symptom response to a nutrient challenge linked to gastric motor dysfunction.
abstract: BACKGROUND
  Bleeding peptic ulcer (BPU) frequently occurs in the absence of preceding dyspeptic symptoms. We have observed that patients with BPU had a diminished symptom response to nutrient challenge test compared to uncomplicated peptic ulcer disease (uPUD). We postulated that more symptoms are manifest in patients with uPUD than BPU because there are greater derangements in gastric motor function.
  
  
  OBJECTIVE
  To assess gastric emptying in patients with BPU, uPUD and healthy controls (HC).
  
  
  METHODS
  We studied 17 patients with BPU, 10 with uPUD, and 15 HC. After an 8-hour fast, subjects ingested 200 ml of an enteral feeding solution, containing 5 MBq (99m)Tc-rhenium sulphide colloid, every 5 min up to a cumulative volume of 800 ml. Gastric emptying was measured by scintigraphy for the total, proximal and distal stomach.
  
  
  RESULTS
  Patients with uPUD had significantly higher gastric retention in the proximal and total stomach at 100 min than HC and BPU, while BPU had similar percent retention to HC. Patients with uPUD had significantly higher cumulative symptom response to the nutrient challenge than did HC and BPU, while BPU had similar symptom responses to HC.
  
  
  CONCLUSIONS
  Patients with uPUD have significantly delayed gastric emptying compared to HC and BPU. Data suggest that in addition to alterations of visceral sensory function, altered gastric motor function occurs during a nutrient challenge in uPUD but not BPU. Gastric motor function may contribute to the manifestation of dyspeptic symptoms in PUD.
authors.affiliation: Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, S.A., Australia.
authors.forename: Montri
authors.initials: M
authors.lastname: Gururatsakul
authors.forename: Richard H
authors.initials: RH
authors.lastname: Holloway
authors.forename: Max
authors.initials: M
authors.lastname: Bellon
authors.forename: Dylan
authors.initials: D
authors.lastname: Bartholomeusz
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Talley
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Holtmann
mesh_terms: D000368:Aged; D004415:Dyspepsia / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis* / Q000503:physiopathology; D012528:Satiety Response / Q000502:physiology; D011795:Surveys and Questionnaires; D014781:Viscera / Q000294:innervation