title: A bioinspired catalytic oxygenase cascade to generate complex oxindoles.
abstract: Catalytic, selective, and controlled oxidative functionalization of C-H bonds using molecular oxygen as an oxidant remains highly desirable and equally challenging in the development of synthetic methodologies. Presented herein is a one-pot oxygenase cascade reaction wherein a copper(I)-catalyzed oxygenase reaction transforms the allylic methyl group in 3-methylidene oxindoles into an aldehyde, which then undergoes an aldol-oxa-Michael addition sequence with β-ketoesters to yield dihydrofuran-bearing oxindoles.
authors.affiliation: Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany) http://www.mpi-dortmund.mpg.de/74401/Kumar.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Bauer
authors.forename: Carsten
authors.initials: C
authors.lastname: Strohmann
authors.forename: Kamal
authors.initials: K
authors.lastname: Kumar
mesh_terms: D055162:Biocatalysis; D007211:Indoles / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*
chemical_list: D007211:Indoles; D010105:Oxygenases
keywords: allylic compounds; bioinspired catalysis; copper; heterocycles; oxidation