title: Septic encephalopathy: does inflammation drive the brain crazy?
abstract: Sepsis and the multiorgan dysfunction syndrome are among the most common reasons for admission to an intensive care unit, and are a leading cause of death. During sepsis, the central nervous system (CNS) is one of the first organs affected, and this is clinically manifested as sepsis-associated encephalopathy (SAE). It is postulated that the common final pathway that leads to SAE symptoms is the deregulation of neurotransmitters, mainly acetylcholine. Thus, it is supposed that inflammation can affect neurotransmitters, which is associated with SAE development. In this review, we will cover the current evidence (or lack thereof) for the mechanisms by which systemic inflammation interferes with the metabolism of major CNS neurotransmitters, trying to explain how systemic inflammation drives the brain crazy.
authors.affiliation: Laboratory of Experimental Pathophysiology and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Research Center, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.affiliation: Laboratory of Experimental Pathophysiology and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Research Center, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Cristiane D
authors.initials: CD
authors.lastname: Tomasi
authors.affiliation: Laboratory of Experimental Pathophysiology and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Research Center, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Ritter
mesh_terms: D000588:Amines / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D004660:Encephalitis / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D018805:Sepsis / Q000378:metabolism / Q000503:physiopathology*; D065166:Sepsis-Associated Encephalopathy / Q000378:metabolism / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000588:Amines; D016207:Cytokines; D005680:gamma-Aminobutyric Acid