title: Prevalence of DRESS syndrome.
abstract: DRESS syndrome (Drug rash with Eosinophilia and Systemic Symptoms) is an idiosyncratic reaction (type B), characterized by peripheral eosinophilia and systemic symptoms, such as fever, rash, lymphadenopathy, hepatitis, atypical lymphocytes and elevation of liver enzymes at least twice its normal level or increase of alanine amino transferase (ALT) >100 U/L. Its incidence is of 1/1,000 to 10,000 exposures and its mortality is of 10%-20%. Treatment is based on steroids and on the suspension of the suspect drug. This paper reports the cases of six patients with DRESS syndrome attended at Centro Medico Nacional Siglo XXI, Mexico City, from September 2012 to September 2013, which accounted for 12.5% of patients attended with adverse reactions to drugs.
authors.affiliation: Hospital de Especialidades, Centro Médico Nacional Siglo XXI. Avenida Cuauhtémoc 330, 06720 México, DF. aeri_05@hotmail.com.
authors.forename: Eunice
authors.initials: E
authors.lastname: López-Rocha
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Blancas
authors.forename: Karen
authors.initials: K
authors.lastname: Rodríguez-Mireles
authors.forename: Arturo
authors.initials: A
authors.lastname: Gaspar-López
authors.forename: Patricia
authors.initials: P
authors.lastname: O'Farrill-Romanillos
authors.forename: Adela
authors.initials: A
authors.lastname: Amaya-Mejía
authors.forename: Lucy
authors.initials: L
authors.lastname: Galindo-Pacheco
authors.forename: Freya
authors.initials: F
authors.lastname: Campos-Romero
authors.forename: Nadia
authors.initials: N
authors.lastname: Aguilar-Hinojosa
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Suárez
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D008954:Models, Biological; D010672:Phenytoin / Q000009:adverse effects; D015995:Prevalence; D014505:Urban Population; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin
keywords: DRESS syndrome; Drug-reactions; Eosinophilia; Exantema; Systemic symptoms