title: Efficacy of Malarone(®) in dogs naturally infected with Babesia gibsoni.
abstract: The efficacy of Malarone(®) alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone(®) relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone(®) and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.
authors.affiliation: Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Iguchi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shiranaga
authors.forename: Aya
authors.initials: A
authors.lastname: Matsuu
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hikasa
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D053626:Atovaquone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001403:Babesia / Q000254:growth & development*; D001404:Babesiosis / Q000188:drug therapy / Q000469:parasitology*; D001663:Bilirubin / Q000032:analysis; D001772:Blood Cell Count / Q000662:veterinary; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D004318:Doxycycline / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000662:veterinary; D005260:Female; D005916:Globulins / Q000032:analysis; D008297:Male; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D002727:Proguanil / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012709:Serum Albumin / Q000032:analysis
chemical_list: D016054:DNA, Protozoan; D004338:Drug Combinations; D005916:Globulins; D012709:Serum Albumin; C109496:atovaquone, proguanil drug combination; D003404:Creatinine; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D004318:Doxycycline; D001663:Bilirubin; D002727:Proguanil; D053626:Atovaquone