title: Two new eunicellin-based diterpenoids from the South China Sea gorgonian Muricella sibogae Nutting.
abstract: Two new eunicellin-based diterpenoids, sibogins A (1) and B (2), along with one known analogue (3), and four known 9,10-secosteroids (4-7), were isolated from the gorgonian Muricella sibogae Nutting collected from the South China Sea. The structures of the new compounds were elucidated by comprehensive analysis of spectroscopic data, especially by using 2D NMR spectra. The antifouling activity on barnacle Balanus amphitrite and lethality towards brine shrimp Artemia salina of all the isolated compounds were evaluated.
authors.affiliation: a Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , 5 Yushan Road, Qingdao 266003 , Shandong , P.R. China.
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Fu
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Fang
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D057219:Biofouling / Q000517:prevention & control; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D009792:Oceans and Seas; D001468:Thoracica / Q000187:drug effects
chemical_list: D004224:Diterpenes; C476503:eunicellin; C000592994:sibogin A; C000592995:sibogin B
keywords: 9,10-secosteroid; Muricella sibogae; eunicellin-based diterpenoid; gorgonian