title: Association between periodontal disease and plasma levels of cholesterol and triglycerides.
abstract: OBJECTIVE
  untreated periodontal disease seems to cause low grade systemic inflammation and blood lipid alteration leading to increased cardiovascular disease risk. To start testing this hypothesis in colombian patients, a multicentre study was conducted including the three main state capitals: bogota, medellin and cali.
  
  
  METHODS
  in this study 192 (28.4%) advanced and 256 (37.8%) moderate periodontitis patients were investigated for socio-demographic variables, city of precedence, periodontal parameters, smoking, red complex periodontopathic bacteria, serum antibodies against porphyromonas gingivalis and aggregatibacter actinomycetemcomitans and blood lipids including total cholesterol, hdl, ldl and triglycerides (tg). Those parameters were compared to 229 (33.8%) controls having periodontal health or gingivitis.
  
  
  RESULTS
  advanced periodontitis had worst periodontal indexes, than moderate periodontitis and controls. Interestingly, higher hdl and tg levels were present in periodontitis. Bmi <30 and smoking were associated with increased hdl, hdl-35, ldl and tg, while glycemia >100 mg/dl associated with hdl, hdl-35 and tg. Tannerella forsythia showed a significant association with hdl-35 in bivariate analysis and serum igg1 against p. Gingivalis associated with hdl-35 and serum igg1 against t. Forsythia associated with tg and serum igg2 against a. Actinomycetemcomitans correlated with levels of hdl y hdl-35. In logistic regression the periodontitis patients from cali presented reduced hdl levels as compared to bogota and medellin patients. Presence of igg1 antibodies against p. Gingivalis and a. Actinomycetemcomitans correlated with reduced hdl levels.
  
  
  CONCLUSIONS
  this study confirmed that untreated periodontitis generates alteration in serum lipid levels and systemic bacterial exposure against important periodontopathic bacteria could be the biological link.
authors.affiliation: Periodontal Medicine Group, School of Dentistry, Universidad del Valle. E-mail: adolfoco@yahoo.com.
authors.forename: Adriana
authors.initials: A
authors.lastname: Jaramillo
authors.affiliation: Instituto UIBO, Faculty of Dentistry, Universidad El Bosque. E-mail: institutouibo@gmail.com.
authors.forename: Gloria Inés
authors.initials: GI
authors.lastname: Lafaurie
authors.affiliation: Instituto UIBO, Faculty of Dentistry, Universidad El Bosque. E-mail: institutouibo@gmail.com.
authors.forename: Lina Viviana
authors.initials: LV
authors.lastname: Millán
authors.affiliation: Universidad de Antioquia, Medellin Colombia. E-mail: martinardila@gmail.com.
authors.forename: Carlos Martin
authors.initials: CM
authors.lastname: Ardila
authors.affiliation: Faculty of Dentistry, Universidad CES. E-mail: aduqued@ces.edu.co.
authors.forename: Andrés
authors.initials: A
authors.lastname: Duque
authors.affiliation: Faculty of Dentistry, Pontificia Universidad Javeriana. E-mail: novoacamilo@hotmail.com.
authors.forename: Camilo
authors.initials: C
authors.lastname: Novoa
authors.affiliation: School of Dentistry, Universidad del Valle. E-mail: dilote@hotmail.com.
authors.forename: Diego
authors.initials: D
authors.lastname: López
authors.affiliation: Periodontal Medicine Group, School of Dentistry, Universidad del Valle. E-mail: adolfoco@yahoo.com.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Contreras
keywords: HDL; LDL; Periodontal disease; dyslipidemia; triglycerides