title: Metachronous myxofibrosarcoma and osteosarcoma: case report and review of the literature.
abstract: The occurrence of multiple primary sarcomas in one individual is very uncommon and the development of osteosarcoma as a second tumor following a soft tissue sarcoma is extremely rare. We report a case of a 62-year-old man who developed 2 histologically distinct sarcomas: a soft tissue myxofibrosarcoma and vertebral osteosarcoma. This unusual case highlights the critical role of careful histopathological evaluation in distinguishing synchronous or metachronous neoplasia from metastatic tumor. To the best of the authors' knowledge, this is the first reported case of metachronous soft tissue myxofibrosarcoma and osteosarcoma.
authors.affiliation: The Ulster Hospital, Belfast, Northern Ireland.
authors.forename: Rachael
authors.initials: R
authors.lastname: Caffrey
authors.affiliation: The Ulster Hospital, Belfast, Northern Ireland.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Robinson
authors.affiliation: The Ulster Hospital, Belfast, Northern Ireland.
authors.forename: Satyen
authors.initials: S
authors.lastname: Shukla
authors.affiliation: Northern Ireland Cancer Center, Belfast, Northern Ireland.
authors.forename: Heather
authors.initials: H
authors.lastname: McCarty
authors.affiliation: The Ulster Hospital, Belfast, Northern Ireland.
authors.forename: Alastair
authors.initials: A
authors.lastname: Brown
authors.affiliation: Royal Group of Hospitals, Belfast, Northern Ireland oisin.houghton@belfasttrust.hscni.net.
authors.forename: Oisín P
authors.initials: OP
authors.lastname: Houghton
mesh_terms: D005354:Fibrosarcoma / Q000473:pathology*; D005542:Forearm / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013125:Spinal Neoplasms / Q000473:pathology*; D013904:Thoracic Vertebrae / Q000473:pathology
keywords: multiple sarcomas; myxofibrosarcoma; osteosarcoma; sarcoma; synchronous neoplasia; synchronous sarcomas