title: Indole synthesis based on a modified Koser reagent.
abstract: A new metal-free method for the rapid and productive preparation of indoles has been developed. This process is based on sterically congested hypervalent iodine compounds of the family of Koser reagents, and iodosobenzene in combination with 2,4,5-tris-isopropylbenzene sulfonic acid provides the highest yields and fastest reaction times. This reagent alone promotes the chemoselective oxidative cyclization of 2-amino styrenes to indoles in high yields under mild conditions.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona (Spain).
authors.forename: Laura
authors.initials: L
authors.lastname: Fra
authors.forename: Alba
authors.initials: A
authors.lastname: Millán
authors.forename: José A
authors.initials: JA
authors.lastname: Souto
authors.forename: Kilian
authors.initials: K
authors.lastname: Muñiz
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000586:Amination; D002623:Chemistry Techniques, Analytical; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D013997:Time Factors
chemical_list: D000475:Alkenes; D007211:Indoles; D007455:Iodine
keywords: amination; catalysis; hypervalent iodine; indole; oxidation