title: [Renal denervation for treating hypertension: experience at the University Hospital in Lyon].
abstract: OBJECTIVE
  We report the first experience of Lyon's university hospital regarding renal denervation to treat patients with resistant essential hypertension.
  
  
  METHODS
  Over a one-year period, 17 patients were treated (12 men, 5 women) with renal denervation. Baseline characteristics were as follows: age 56.5±11.5 years, BMI 33±5kg/m(2) and ambulatory blood pressure 157±16/87±13mmHg with 4.2±1.5 anti-hypertensive treatment.
  
  
  RESULTS
  We did not observe intra-operative or early complications. After a median follow-up of 3 months and with the same anti-hypertensive treatment, office systolic blood pressure (SBP) and diastolic blood pressure (DBP) decrease respectively of 20±15 (P<0.001) and 10±13mmHg (P=0.014) (n=17). After six months of follow-up, ambulatory blood pressure (ABPM) decrease of 17.5±14.9mmHg (P=0.027) for SBP and of 10.5±9.6mmHg (P=0.029) for DBP (n=6). Among these patients, five of them were controlled (ABPM inferior to 130/80mmHg) and electrical left ventricular hypertrophy indexes decreased: R wave in aVL lead of 4±3mm (P=0.031), Sokolow index of 3±3mm (P=0.205), Cornell voltage criterion of 9±7mm (P=0.027) and Cornell product of 1310±1104 (P=0.027).
  
  
  CONCLUSIONS
  Our results are in accordance with data from other centers. On average blood pressure decreases significantly but important inter individual variations are observed. The procedure seems safe.
authors.affiliation: Service de cardiologie, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hôpital Nord-Ouest, 69400 Villefranche sur Saône, France. Electronic address: pycourand@hotmail.com.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Courand
authors.affiliation: Service de cardiologie, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hôpital Nord-Ouest, 69400 Villefranche sur Saône, France.
authors.forename: R
authors.initials: R
authors.lastname: Dauphin
authors.affiliation: Service de radiologie, hôpital Edouard-Herriot, hospices civils de Lyon, 69008 Lyon, France; EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hôpital Nord-Ouest, 69400 Villefranche sur Saône, France.
authors.forename: O
authors.initials: O
authors.lastname: Rouvière
authors.affiliation: Service de cardiologie, hôpital Nord-Ouest, 69008 Villefranche sur Saône, France.
authors.forename: V
authors.initials: V
authors.lastname: Paget
authors.affiliation: Service de cardiologie, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Khettab
authors.affiliation: Service de cardiologie, hôpital Louis-Pradel, hospices civils de Lyon, 69400 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Bergerot
authors.affiliation: Service de cardiologie, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
authors.forename: B
authors.initials: B
authors.lastname: Harbaoui
authors.affiliation: EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France.
authors.forename: G
authors.initials: G
authors.lastname: Bricca
authors.affiliation: Service de néphrologie, hôpital Edouard-Herriot, hospices civils de Lyon, 69008 Lyon, France; EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hôpital Nord-Ouest, 69400 Villefranche sur Saône, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Fauvel
authors.affiliation: Service de cardiologie, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hôpital Nord-Ouest, 69400 Villefranche sur Saône, France.
authors.forename: P
authors.initials: P
authors.lastname: Lantelme
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D003714:Denervation / Q000379:methods; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000601:surgery*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007668:Kidney / Q000294:innervation; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D012077:Renal Artery / Q000294:innervation / Q000601:surgery*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Dénervation rénale; Hypertension essentielle; Hypertension résistante; Hypertrophie ventriculaire gauche; Left ventricular hypertrophy; NT-proBNP; Primary hypertension; Renal denervation; Resistant hypertension