title: Do we need readjustment of the biochemical parameters in first trimester combined aneuploidy screening test in women with polycystic ovary syndrome?
abstract: OBJECTIVE
  The aim of this study was to determine whether polycystic ovary syndrome (PCOS) affects the biochemical components of first trimester combined aneuploidy screening test.
  
  
  METHODS
  A case-control study was performed at a tertiary referral hospital between years 2007-2013. Singleton pregnancies in the first trimester (11(+0) -13(+6) week) who had a history of PCOS and underwent first trimester combined aneuploidy screening test were included in the study. Three hundred and seventeen women met the criteria for inclusion. Control group was formed by 942 healthy pregnant women with similar gestational and maternal ages using a 1 : 3 ratio. Pregnancy-associated plasma protein-A (PAPP-A), free β-human chorionic gonadotropin (fβ-hCG) and fetal nuchal translucency were compared between the study group and the controls.
  
  
  RESULTS
  The biochemical components PAPP-A and fβ-hCG were significantly lower in the PCOS group compared with the control group (p = 0.001). There was no difference among groups with regard to the nuchal translucency measurements (p = 0.128).
  
  
  CONCLUSIONS
  Our study shows that the levels of biochemical components of first trimester combined aneuploidy screening test (PAPP-A and fβ-hCG) are altered in pregnant women with PCOS. Future trials of larger scale are needed to asses any need for readjustment of the risk in the patient population with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Sami Ulus Women's and Children's Health and Research Teaching Hospital, Ankara, Turkey.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karsli
authors.forename: Ismail Burak
authors.initials: IB
authors.lastname: Gultekin
authors.forename: Bulent
authors.initials: B
authors.lastname: Cakmak
authors.forename: Mahmut Ilkin
authors.initials: MI
authors.lastname: Yeral
authors.forename: Kerem Doga
authors.initials: KD
authors.lastname: Seckin
authors.forename: Orhan
authors.initials: O
authors.lastname: Alt Nboga
authors.forename: Tuncay
authors.initials: T
authors.lastname: Kucukozkan
mesh_terms: D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D048208:Nuchal Translucency Measurement; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000235:genetics; D011261:Pregnancy Trimester, First / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis / Q000379:methods*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A