title: Therapeutic management of anal eczema: an evidence-based review.
abstract: OBJECTIVE
  To conduct a systematic review of treatments for anal eczema (AE).
  
  
  METHODS
  We conducted a Medline search for clinical trial data for the treatment of perianal diseases including AE, including papers not published in the English language. We assessed the study reports using the system recommended by the Oxford Centre for Evidence-based Medicine. No meta-analysis was attempted.
  
  
  RESULTS
  The evidence base for topical treatments used to treat AE is very poor: there are very few studies and many of those that exist are of poor quality. The best evidence was found for medications that are yet to be licensed for AE. Among products with existing licences for the treatment of eczema, our assessment found some evidence to support the continued use of mild-to-moderate corticosteroids first line in most patients.
  
  
  CONCLUSIONS
  Features of the perianal region, and the fact that it is almost always occluded, mean that not all medications recommended in the general treatment guidelines for eczema are appropriate for AE. However, there are no specific treatment guidelines for these patients. This may in part be because of the lack of high-quality evidence-based medicine in this therapy area. Many frequently prescribed medications were developed and licensed many years ago, in an era when clinical trial design was not expected to be as rigorous as it is today.
  
  
  CONCLUSIONS
  This review highlights the need to conduct more high-quality clinical trials in patients with AE in order that specific guidelines for the management of this difficult proctological condition can be prepared.
authors.affiliation: Global Clinical Development Dermatology, Bayer HealthCare, Berlin, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Havlickova
authors.forename: G H
authors.initials: GH
authors.lastname: Weyandt
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D001003:Anal Canal / Q000002:abnormalities; D003362:Cost-Benefit Analysis; D004485:Eczema / Q000150:complications / Q000188:drug therapy*; D019317:Evidence-Based Medicine; D006801:Humans
chemical_list: D000305:Adrenal Cortex Hormones