title: Intratypic heterologous vaccination of calves can induce an antibody response in presence of maternal antibodies against foot-and-mouth disease virus.
abstract: BACKGROUND
  Maternal antibodies can interfere with foot-and-mouth disease vaccination. In this study we determined whether intratypic heterologous vaccination could help to improve herd immunity.
  
  
  RESULTS
  In unvaccinated calves, a half-life of maternal antibodies of 21 days was determined. At two weeks of age, calves without maternal antibodies showed a good antibody response against both vaccines used in the trial, while in calves with maternal antibodies no antibody response to homologous vaccination (A Turkey 14/98) but a limited antibody response to intratypic heterologous vaccination (A22 Iraq) was observed.
  
  
  CONCLUSIONS
  Two weeks old calves without maternal antibodies respond well to vaccination, but when emergency vaccination is carried out in a region that uses prophylactic vaccination, using an intratypic heterologous vaccine strain may improve the immunity in calves with maternal antibodies.
authors.affiliation: Central Veterinary Institute of Wageningen UR, P,O, Box 65, 8200 AB Lelystad, The Netherlands. Aldo.Dekker@wur.nl.
authors.forename: Aldo
authors.initials: A
authors.lastname: Dekker
authors.forename: Phaedra
authors.initials: P
authors.lastname: Eblé
authors.forename: Norbert
authors.initials: N
authors.lastname: Stockhofe
authors.forename: Gilles
authors.initials: G
authors.lastname: Chénard
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000517:prevention & control*; D005536:Foot-and-Mouth Disease / Q000097:blood / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines