title: Cell therapy in dermatology.
abstract: Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in dermatology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.
authors.affiliation: St. John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 1UL, United Kingdom.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Petrof
authors.affiliation: St. John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 1UL, United Kingdom.
authors.forename: Alya
authors.initials: A
authors.lastname: Abdul-Wahab
authors.affiliation: St. John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 1UL, United Kingdom.
authors.forename: John A
authors.initials: JA
authors.lastname: McGrath
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D017690:Cell Transplantation / Q000379:methods*; D002478:Cells, Cultured / Q000637:transplantation; D003880:Dermatology / Q000379:methods*; D005347:Fibroblasts / Q000637:transplantation; D048091:Guided Tissue Regeneration; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D012871:Skin Diseases / Q000628:therapy*; D016038:Skin Transplantation; D023822:Tissue Engineering / Q000379:methods