title: Aortic valve disease.
abstract: Aortic valve disease is common and has significant impact on prognosis and quality of life. In this educational review, we cover the pathophysiology, presentation and assessment of aortic stenosis (AS) and aortic regurgitation (AR), including the role of imaging modalities beyond echocardiography. We review current treatment strategies and emphasise the use and indications for transcatheter aortic valve implantation (TAVI) in view of recent data highlighting its emergence as a novel treatment option for patients with AS, who are unsuitable for conventional aortic valve replacement (AVR). We also describe novel surgical approaches for AR and potential future strategies for percutaneous intervention.
authors.affiliation: Department of Cardiology, Oxford University Hospitals NHS Trust, Oxford, UK.
authors.forename: J
authors.initials: J
authors.lastname: Rayner
authors.forename: S
authors.initials: S
authors.lastname: Coffey
authors.forename: J
authors.initials: J
authors.lastname: Newton
authors.forename: B D
authors.initials: BD
authors.lastname: Prendergast
mesh_terms: D001021:Aortic Valve / Q000473:pathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D000082882:Bicuspid Aortic Valve Disease; D006328:Cardiac Catheterization / Q000706:statistics & numerical data*; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D006349:Heart Valve Diseases / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D011788:Quality of Life; D016896:Treatment Outcome; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*