title: Organochlorine pesticide levels in maternal serum and risk of neural tube defects in offspring in Shanxi Province, China: a case-control study.
abstract: Organochlorine pesticides (OCPs) in placental tissue have been reported to be associated with an increased risk for fetal neural tube defects (NTDs). Our case-control study was performed to explore the association between maternal serum OCP concentration and NTD risk in offspring. Serum samples were collected from 117 mothers who delivered NTD infants (case group) and 121 mothers who delivered healthy infants (control group). Only three of the 25 OCPs were detected in more than half of the maternal serum samples. The median concentration of total OCPs in the case group was significantly higher than that of the control group. However, no dose-response relationships between higher levels of any individual OCPs or total OCPs and the risk of NTDs or subtypes were observed in either the unadjusted binary unconditional logistic regression model or the model adjusted by potential confounders. We conclude that no clear association between maternal serum OCP residues and NTD risk in offspring was observed in this population.
  No clear association between maternal serum levels of organochlorine pesticides and risk of neural tube defects in offspring was observed for a Chinese population.
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Yi
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jin
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Jufen
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, PR China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Liu
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Shu
authors.initials: S
authors.lastname: Tao
authors.affiliation: Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China. Electronic address: renag@bjmu.edu.cn.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Ren
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D009436:Neural Tube Defects / Q000453:epidemiology*; D010575:Pesticides / Q000097:blood*; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides
keywords: Case–control study; Maternal serum; Neural tube defect; Organochlorine pesticides; Risk