title: Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.
abstract: We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.
authors.affiliation: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
authors.forename: Huayun
authors.initials: H
authors.lastname: Deng
authors.affiliation: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
authors.forename: Haibei
authors.initials: H
authors.lastname: Hu
authors.affiliation: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
authors.forename: Shizhang
authors.initials: S
authors.lastname: Ling
authors.affiliation: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Ferrie
authors.affiliation: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
authors.forename: Ye
authors.initials: Y
authors.lastname: Fang
keywords: GPR35; biased agonism; ellagic acid; natural phenols