title: Mesenchymal stem cell therapy and acute graft-versus-host disease: a review.
abstract: Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, particularly in the treatment of conditions involving autoimmune and inflammatory components. Nevertheless, many research findings are still contradictory, mostly due to difficulties in characterization of the effects of MSCs in vivo. The purpose of this review is to report the mechanisms underlying mesenchymal stem cell therapy for acute graft-versus-host disease, particularly with respect to immunomodulation, migration, and homing, as well as report clinical applications described in the literature.
authors.affiliation: Cell Therapy Center, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil, bruamorin@gmail.com.
authors.forename: Bruna
authors.initials: B
authors.lastname: Amorin
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Alegretti
authors.forename: Vanessa
authors.initials: V
authors.lastname: Valim
authors.forename: Annelise
authors.initials: A
authors.lastname: Pezzi
authors.forename: Alvaro Macedo
authors.initials: AM
authors.lastname: Laureano
authors.forename: Maria Aparecida Lima
authors.initials: MA
authors.lastname: da Silva
authors.forename: Andréa
authors.initials: A
authors.lastname: Wieck
authors.forename: Lucia
authors.initials: L
authors.lastname: Silla
mesh_terms: D000208:Acute Disease; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D056747:Immunomodulation; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*