title: Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?
abstract: Early events driving the initiation and evolution of neoplasms remain poorly defined but involvement of an instructive or permissive niche has been implicated. In this issue of Cell Stem Cell, Medyouf et al. (2014) provide insights into the role of the niche in myelodysplastic syndromes, the principle preleukemic disorder of the hematopoietic system.
authors.affiliation: Department of Hematology, Erasmus MC Cancer Institute, and Erasmus Stem Cell Institute, Faculty Building Rm Ee-1393, dr. Molewaterplein 50, 3015GE, Rotterdam, The Netherlands. Electronic address: m.h.g.raaijmakers@erasmusmc.nl.
authors.forename: Marc H G P
authors.initials: MH
authors.lastname: Raaijmakers
mesh_terms: D000818:Animals; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism* / Q000473:pathology*; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000473:pathology*; D055153:Stem Cell Niche