title: Storage in ultra-low-temperature decreases the levels of IgM anticardiolipin antibody in serum samples from tuberculosis patients.
abstract: The evaluation of novel tuberculosis (TB) biomarkers relies on analysis of previously stored sample sets. We aimed to determine the effect of storage temperature on serum IgM anticardiolipin antibody levels in samples from TB patients. Ultra-low-temperature storage decreased IgM anticardiolipin levels. We recommend against using ultra-low-temperature storage when investigating IgM anticardiolipin biomarker-based tests.
authors.affiliation: Stony Brook University, Stony Brook, NY, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ng
authors.affiliation: Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, INDICASAT-AIP, City of Knowledge, Panama.
authors.forename: Cheyenne
authors.initials: C
authors.lastname: Weeks-Galindo
authors.affiliation: Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, INDICASAT-AIP,Edificio 219, City of Knowledge, 0843-01103, Panama amadorgj@yahoo.com.
authors.forename: Amador
authors.initials: A
authors.lastname: Goodridge
keywords: Biomarker; IgM anti-cardiolipin; storage temperature; therapy monitoring; tuberculosis