title: Higher HIV DNA in CD4+ naïve T-cells during acute HIV-1 infection in rapid progressors.
abstract: AbFew reports have shown the relationship between the distribution of human immunodeficiency virus type 1 (HIV-1) proviral DNA in CD4 subsets during acute HIV-1 infection and HIV disease progression. In this study, we enrolled two groups with distinct differences in disease progression. The CD4 counts of one group fell below 200 cells/μL within 2 years (rapid progressors), whereas the other group maintained CD4 counts above 500 cells/μL (slow progressors). We collected blood samples during Fiebig stage III-IV of the two groups, and sorted CD4+ naïve, central memory, and effector memory lymphocytes. Real-time polymerase chain reaction was used to quantify HIV-1 DNA of the subsets. We found that HIV-1 DNA content was higher in memory T-cells than in naïve cells in both groups, and a higher HIV DNA content was found in naïve CD4+ T-cells during acute HIV-1 infection in rapid progressors. This suggests that higher HIV DNA in naïve CD4+ T-cells may associated with rapid progression.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Jiao
authors.forename: Jingjing
authors.initials: J
authors.lastname: Song
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.forename: Weijun
authors.initials: W
authors.lastname: Zhu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Dexi
authors.initials: D
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015331:Cohort Studies; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D004279:DNA, Viral