title: Clinical outcome of successful percutaneous coronary intervention for chronic total occlusion: results from the multicenter Korean Chronic Total Occlusion (K-CTO) registry.
abstract: OBJECTIVE
  To investigate the impact of the success or failure of chronic total occlusion (CTO) interventions on the clinical outcomes in the current drug-eluting stent (DES) era.
  
  
  BACKGROUND
  The impact of the successful CTO intervention on long-term clinical outcomes still remains unclear.
  
  
  METHODS
  Between 2007 and 2009, a total of 2568 patients with CTO were followed in a multicenter Korean CTO registry. Of these, successful recanalization with DESs occurred in 2045 patients (successful CTO group), whereas failure occurred in 523 patients (failed CTO group).
  
  
  RESULTS
  The occurrence of the composite of cardiac death and myocardial infarction (MI) was compared between the successful CTO and failed CTO groups. During follow-up (median duration, 729 days), the occurrence of cardiac death or MI was significantly lower in the successful CTO group than in the failed CTO group (1.7% vs 3.3%; hazard ratio, 0.50; 95% confidence interval, 0.28-0.91; P=.02) and the cumulative occurrence in the successful CTO group was also significantly lower than in the failed CTO group (1.7% vs 3.0%; P=.03) by the Kaplan-Meier method. The successful CTO group had a significantly lower need for bypass surgery than the failed CTO group (0.2% vs 2.5%; P<.001). In multivariate analysis, procedural success of CTO (odds ratio, 0.51; 95% CI, 0.29-0.92) was significantly predictive of the occurrence of cardiac death or MI, together with age and left ventricular ejection fraction <40%.
  
  
  CONCLUSIONS
  This registry study demonstrated that successful CTO intervention with DESs compared to failed CTO intervention was associated with lower event rates during follow-up.
authors.affiliation: Yonsei Cardiovascular Center, Yonsei University College of Medicine, Division of Cardiology of Yonsei Cardiovascular Center, Seodaemun-gu, Shinchondong, Shinchon Severance Hospital, Seoul 120-752, South Korea. Jangys1212@yuhs.ac.
authors.forename: Byeong-Keuk
authors.initials: BK
authors.lastname: Kim
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Shin
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Shin
authors.forename: Myeong-Ki
authors.initials: MK
authors.lastname: Hong
authors.forename: Hyeon-Cheol
authors.initials: HC
authors.lastname: Gwon
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Cheol Woong
authors.initials: CW
authors.lastname: Yu
authors.forename: Hun Sik
authors.initials: HS
authors.lastname: Park
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Chae
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Moo-Hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hur
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
mesh_terms: D000368:Aged; D054059:Coronary Occlusion / Q000453:epidemiology* / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation / Q000379:methods*; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome