title: Preparation and characterization of double crosslinked hydrogel films from carboxymethylchitosan and carboxymethylcellulose.
abstract: A novel crosslinked hydrogel film was prepared from carboxymethylchitosan (CMCS) and carboxymethylcellulose (CMC) by ionical and covalent crosslinking with CaSO4 and genipin, respectively. The swelling ratio of the crosslinked CMCS/CMC hydrogel films was investigated at different pH solutions (1-9), and the results indicated that the crosslinked hydrogels had the swelling-deswelling properties with two primary peaks of swelling ratio at pH 3 and 7. The surface morphologies of the crosslinked hydrogels at different pH values provided evidences of the swelling-deswelling properties. The mechanical properties of the hydrogel films were also examined. The ionical and covalent crosslinking were found to have the primary impact on the toughness and max load, respectively, of the crosslinked hydrogels. The cells comparatively cultured on the crosslinked hydrogels and the negative and positive controls suggested the biocompatibility of the crosslinked CMCS/CMC films. This kind of hydrogel films have potential application in drug delivery vehicles and skin tissue engineering.
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Dengshan
authors.initials: D
authors.lastname: Bao
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Chen
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China.
authors.forename: Jufang
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address: chfliu@scut.edu.cn.
authors.forename: Chuanfu
authors.initials: C
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China; Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
authors.forename: Runcang
authors.initials: R
authors.lastname: Sun
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000138:chemical synthesis* / Q000378:metabolism; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000378:metabolism; D008756:Methylgalactosides / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D003432:Cross-Linking Reagents; D008756:Methylgalactosides; C514968:carboxymethyl-chitosan; C109801:hydrogel film; D048271:Chitosan; D002266:Carboxymethylcellulose Sodium
keywords: Carboxymethylcellulose; Carboxymethylchitosan; Double crosslinking; Film; Hydrogel