title: Porous silicon-cyclodextrin based polymer composites for drug delivery applications.
abstract: One of the main applications of porous silicon (PSi) in biomedicine is drug release, either as a single material or as a part of a composite. PSi composites are attractive candidates for drug delivery systems because they can display new chemical and physical characteristics, which are not exhibited by the individual constituents alone. Since cyclodextrin-based polymers have been proven efficient materials for drug delivery, in this work β-cyclodextrin-citric acid in-situ polymerization was used to functionalize two kinds of PSi (nanoporous and macroporous). The synthesized composites were characterized by microscopy techniques (SEM and AFM), physicochemical methods (ATR-FTIR, XPS, water contact angle, TGA and TBO titration) and a preliminary biological assay was performed. Both systems were tested as drug delivery platforms with two different model drugs, namely, ciprofloxacin (an antibiotic) and prednisolone (an anti-inflammatory), in two different media: pure water and PBS solution. Results show that both kinds of PSi/β-cyclodextrin-citric acid polymer composites, nano- and macro-, provide enhanced release control for drug delivery applications than non-functionalized PSi samples.
authors.affiliation: Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain. Electronic address: jacobo.hernandez@uam.es.
authors.forename: J
authors.initials: J
authors.lastname: Hernandez-Montelongo
authors.affiliation: Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Naveas
authors.affiliation: Unité Matériaux Et Transformations (UMET), Ingénierie des Systèmes Polymères, Université Lille 1, F-59655, Villeneuve D'Ascq, France.
authors.forename: S
authors.initials: S
authors.lastname: Degoutin
authors.affiliation: Unité Matériaux Et Transformations (UMET), Ingénierie des Systèmes Polymères, Université Lille 1, F-59655, Villeneuve D'Ascq, France.
authors.forename: N
authors.initials: N
authors.lastname: Tabary
authors.affiliation: Groupe de Recherche sur Biomatériaux (U 1008 INSERM) Faculté de Médecine, Université Lille 2, F-59045, Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Chai
authors.affiliation: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, 21020, Ispra (Va), Italy.
authors.forename: V
authors.initials: V
authors.lastname: Spampinato
authors.affiliation: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, 21020, Ispra (Va), Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ceccone
authors.affiliation: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, 21020, Ispra (Va), Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Torres-Costa
authors.affiliation: Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Manso-Silvan
authors.affiliation: Unité Matériaux Et Transformations (UMET), Ingénierie des Systèmes Polymères, Université Lille 1, F-59655, Villeneuve D'Ascq, France.
authors.forename: B
authors.initials: B
authors.lastname: Martel
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002939:Ciprofloxacin / Q000008:administration & dosage; D019343:Citric Acid / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D058105:Polymerization; D016062:Porosity; D011239:Prednisolone / Q000008:administration & dosage; D012825:Silicon / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D019343:Citric Acid; D002939:Ciprofloxacin; D011239:Prednisolone; C031215:betadex; D012825:Silicon
keywords: Composites; Drug delivery; Porous silicon; β-Cyclodextrin–citric acid polymer