title: IL-6 strikes a balance in metabolic inflammation.
abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine that exerts either proinflammatory or anti-inflammatory effects and is implicated in diverse settings, including obesity, exercise, arthritis, and colitis. A new study shows that modulation of macrophage activation by IL-6 maintains glucose homeostasis in diet-induced obesity while limiting inflammation in endotoxemia (Mauer et al., 2014).
authors.affiliation: Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Covarrubias
authors.affiliation: Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: thorng@hsph.harvard.edu.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Horng
mesh_terms: D000818:Animals; D019446:Endotoxemia / Q000276:immunology*; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000378:metabolism*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D009765:Obesity / Q000276:immunology*
chemical_list: D015850:Interleukin-6