title: Dominant behaviours in the expression of human carbonic anhydrase hCA I activity.
abstract: Here we describe the screening via Dynamic Deconvolution of DCLs of inhibitors (CAIs) and activators (CAAs) of hCA I. The inhibitory effects dominate over the activating ones, while the CAAs may be identified in the absence of CAIs.
authors.affiliation: Adaptative Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM/UMII/UMR-CNRS 5635, Pl. Eugène Bataillon, CC 047, 34095 Montpellier, Cedex 5, France. mihail-dumitru.barboiu@univ-montp2.fr.
authors.forename: M Yahia M
authors.initials: MY
authors.lastname: Abdelrahim
authors.forename: Muhammet
authors.initials: M
authors.lastname: Tanc
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Mihail
authors.initials: M
authors.lastname: Barboiu
mesh_terms: D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D024401:Carbonic Anhydrase I