title: C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
abstract: Glycogen phosphorylase inhibitors are considered as potential antidiabetic agents. 3-(β-d-Glucopyranosyl)-5-substituted-1,2,4-triazoles were prepared by acylation of O-perbenzoylated N (1)-tosyl-C-β-d-glucopyranosyl formamidrazone and subsequent removal of the protecting groups. The best inhibitor was 3-(β-d-glucopyranosyl)-5-(2-naphthyl)-1,2,4-triazole (K i = 0.41 μM against rabbit muscle glycogen phosphorylase b).
authors.affiliation: Department of Organic Chemistry, University of Debrecen , POB 20, H-4010 Debrecen, Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Bokor
authors.affiliation: Department of Medical Chemistry, Medical and Health Science Centre, University of Debrecen , Egyetem tér 1, H-4032 Debrecen, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Docsa
authors.affiliation: Department of Medical Chemistry, Medical and Health Science Centre, University of Debrecen , Egyetem tér 1, H-4032 Debrecen, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Gergely
authors.affiliation: Department of Organic Chemistry, University of Debrecen , POB 20, H-4010 Debrecen, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Somsák
keywords: 1,2,4-Triazole; C-glucopyranosyl derivative; bioisoster; glycogen phosphorylase; inhibitor