title: Antioxidant status in blood of obese children: the relation between trace elements, paraoxonase, and arylesterase values.
abstract: Obesity is known to lead to complications involving several systems. The basic mechanism in obesity-related complications is chronic inflammation and increased oxidative stress. Trace element levels in obese children may vary due to poor nutritional habits. The purpose of this study was to investigate the relation between serum paraoxonase (PON1) and arylesterase (ARE) levels, markers of the oxidant-antioxidant balance in the body, and serum zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se) concentrations in obese children. Fifty-seven overweight patients aged 6-17 and 48 age- and sex-matched healthy children were included in the study. Serum PON1 and ARE activity levels were measured, together with Cu, Zn, Mn, Se, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, glucose, aspartate amino transferase, and alanine amino transferase levels. PON1 and ARE activity levels were significantly lower in obese patients compared to those in healthy individuals (P < 0.05). Various changes were determined in Cu, Zn, Mn, and Se levels between the study and control groups (P < 0.05). In terms of the relation between trace elements and PON1 and ARE levels, a significant positive correlation was determined between serum Se and PON1 levels in the study group (P < 0.05, r = 0.31). No significant correlation was determined between other trace element levels and PON1 and ARE levels (P > 0.05). In conclusion, the detection in our study of a positive correlation between Se and PON1 levels in obese children may be significant in terms of showing a relation between Se and antioxidant systems in obese children.
authors.affiliation: Faculty of Medicine, Department of Family Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Cayir
authors.forename: Atilla
authors.initials: A
authors.lastname: Cayir
authors.forename: Mehmet Ibrahim
authors.initials: MI
authors.lastname: Turan
authors.forename: Nezahat
authors.initials: N
authors.lastname: Kurt
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kara
authors.forename: Esra
authors.initials: E
authors.lastname: Laloglu
authors.forename: Murat
authors.initials: M
authors.lastname: Ciftel
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildirim
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002648:Child; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000097:blood; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008345:Manganese / Q000097:blood; D009765:Obesity / Q000097:blood*; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014131:Trace Elements; D014280:Triglycerides; D008345:Manganese; D003300:Copper; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D012643:Selenium; D015032:Zinc