title: Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/B preferentially within a protective bone marrow microenvironment.
authors.affiliation: Department of Internal Medicine II, Julius-Maximilians University, Wuerzburg, Germany. Nekova_t@ukw.de.
authors.forename: Tatyana S
authors.initials: TS
authors.lastname: Nekova
authors.forename: Julia
authors.initials: J
authors.lastname: Dotterweich
authors.forename: Norbert
authors.initials: N
authors.lastname: Schütze
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Gernot
authors.initials: G
authors.lastname: Stuhler
mesh_terms: D000498:Allyl Compounds / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001853:Bone Marrow / Q000473:pathology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D038362:Glycogen Synthase Kinase 3 / Q000502:physiology*; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology*; D011799:Quinazolines / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: C560309:6-bromo-4-allylamino-quinazoline; D000498:Allyl Compounds; D000970:Antineoplastic Agents; D011799:Quinazolines; D038362:Glycogen Synthase Kinase 3
keywords: SMER; apoptosis; mesenchymal stem cells; myeloma