title: Dual roles of sulfonyl hydrazides: a three-component reaction to construct fully substituted pyrazoles using TBAI/TBHP.
abstract: A mild and rapid approach has been developed for the construction of fully substituted pyrazoles using TBAI as a catalyst and TBHP as an oxidant, in which tosylhydrazide functions as the ring component and sulfonyl precursor. This protocol features a wide substrate scope with a broad range of functional group tolerance, utilizes easily available starting materials, can be scaled-up, and is operationally simple.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Shao
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Luo
authors.forename: Jijun
authors.initials: J
authors.lastname: Chen
authors.forename: Dongmei
authors.initials: D
authors.lastname: Xu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry; D020122:tert-Butylhydroperoxide / Q000737:chemistry
chemical_list: D006834:Hydrazines; D016877:Oxidants; D011720:Pyrazoles; D000644:Quaternary Ammonium Compounds; D013450:Sulfones; D020122:tert-Butylhydroperoxide; C009405:tetrabutylammonium