title: Selective autophagy goes exclusive.
abstract: Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation.
authors.forename: Terje
authors.initials: T
authors.lastname: Johansen
authors.forename: Trond
authors.initials: T
authors.lastname: Lamark
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001343:Autophagy; D000071190:Autophagy-Related Protein 8 Family; D000071183:Autophagy-Related Proteins; D002462:Cell Membrane / Q000201:enzymology* / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D000071190:Autophagy-Related Protein 8 Family; D000071183:Autophagy-Related Proteins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins; D044763:Ubiquitin-Conjugating Enzymes; D033921:Vesicular Transport Proteins; C434480:ATG19 protein, S cerevisiae; C113757:ATG8 protein, S cerevisiae; C480861:GABARAP protein, mouse; C430503:GABARAPL1 protein, human; C498698:GABARAPL2 protein, human; C526109:Anxa3 protein, rat; C480860:Map1lc3b protein, mouse; C568853:Atg3 protein, mouse