title: Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases.
abstract: Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging.
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakanishi
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Wada
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kitagishi
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuda
keywords: AKT; PI3K; PPAR; PTEN; ROS; SIRT1; WRN; cell signaling