title: Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles.
abstract: An efficient copper-mediated three-component reaction of 2,3-allenoates or 2-alkynoates, amines, and nitriles affording fully substituted pyrazoles with a very nice diversity has been developed. A tandem conjugate addition, 1,2-addition, and N-N bond formation mechanism has been proposed for this diverse synthesis of pyrazoles based on mechanistic studies.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Can
authors.initials: C
authors.lastname: Zhu
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.forename: Shengming
authors.initials: S
authors.lastname: Ma
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis; D000588:Amines / Q000138:chemical synthesis*; D003300:Copper / Q000737:chemistry*; D009281:Naphthalenes / Q000138:chemical synthesis*; D009570:Nitriles / Q000138:chemical synthesis*; D011720:Pyrazoles / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D000588:Amines; D009281:Naphthalenes; D009570:Nitriles; D011720:Pyrazoles; C031280:pyrazole; D003300:Copper; C110055:allenolic acid