title: [Effective chemotherapy with bevacizumab/FOLFOX4 for neuroendocrine carcinoma of the ascending colon - a case study].
abstract: A 63-year-old woman underwent surgery for Stage IV cancer of the ascending colon with multiple lymph node metastases. The pathological diagnosis was neuroendocrine carcinoma. Following first-line chemotherapy, the patient presented clinically with progressive disease (PD). Second-line chemotherapy with bevacizumab/Leucovorin and 5-fluorouracil with oxaliplatin (FOLFOX4) was effective and a partial response (PR) was achieved after 7 courses of therapy, as determined by computed tomography (CT) examination. Neuroendocrine carcinoma is known to be extremely malignant; however, this case suggests that chemotherapy with bevacizumab may improve the prognosis of this disease.
authors.affiliation: Dept. of Surgery, The Kainan Hospital Aichi Prefectural Federation of Agricultural Cooperatives for Health and Welfare.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanabe
authors.forename: Tsunenobu
authors.initials: T
authors.lastname: Takase
authors.forename: Daishi
authors.initials: D
authors.lastname: Morimoto
authors.forename: Yuri
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Arihiro
authors.initials: A
authors.lastname: Shibata
authors.forename: Toyohisa
authors.initials: T
authors.lastname: Yaguchi
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000068258:Bevacizumab; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000601:surgery; D044682:Colon, Ascending / Q000473:pathology*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000068258:Bevacizumab; D002955:Leucovorin; D005472:Fluorouracil