title: 2-methoxyestradiol plasma levels are associated with clinical severity indices and biomarkers of preeclampsia.
abstract: We investigated whether clinical severity indices and biomarkers for preeclampsia (PE) are associated with low plasmatic 2-methoxyestradiol (2ME) in the third trimester of gestation. Blood was collected from 53 women with PE and 73 control pregnant women before parturition. The concentration of 2ME was significantly higher in controls than in patients with PE (2906.43 ± 200.69 pg/mL vs 1818.41 ± 189.25 pg/mL). The risk of PE decreased as 2ME levels increased. The 2ME values were negatively correlated with systolic peak arterial pressure and proteinuria in PE. Additionally, those women with PE with lower 2ME had a more serious clinical situation and needed a more aggressive therapy. Finally, 2ME levels (in patients with PE and total population) were significantly correlated with concentrations of soluble fms-like tyrosine kinase 1 and placental growth factor . Summarizing, patients with PE had lower 2ME levels that were correlated with different clinical indices and biomarkers of severity, indicating that 2ME could be taken into account for the clinical management of this syndrome.
authors.affiliation: Department of Gynaecology and Obstetrics, "Virgen de la Arrixaca" Clinical Universitary Hospital, El Palmar (Murcia), Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Pertegal
authors.affiliation: Department of Physiology, School of Medicine, University of Murcia, Espinardo (Murcia) Spain fjfenoy@um.es.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Fenoy
authors.affiliation: Department of Physiology, School of Medicine, University of Murcia, Espinardo (Murcia) Spain.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bonacasa
authors.affiliation: Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, School of Medicine, University of Murcia, Espinardo (Murcia), Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Mendiola
authors.affiliation: Department of Gynaecology and Obstetrics, "Virgen de la Arrixaca" Clinical Universitary Hospital, El Palmar (Murcia), Spain.
authors.forename: Juan L
authors.initials: JL
authors.lastname: Delgado
authors.affiliation: Department of Physiology, School of Medicine, University of Murcia, Espinardo (Murcia) Spain.
authors.forename: Moises
authors.initials: M
authors.lastname: Hernández
authors.affiliation: Department of Physiology, School of Medicine, University of Murcia, Espinardo (Murcia) Spain.
authors.forename: Miguel G
authors.initials: MG
authors.lastname: Salom
authors.affiliation: Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, School of Medicine, University of Murcia, Espinardo (Murcia), Spain Department of Pediatrics, "Virgen de la Arrixaca" Clinical Universitary Hospital, El Palmar (Murcia), Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Bosch
authors.affiliation: Department of Physiology, School of Medicine, University of Murcia, Espinardo (Murcia) Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
mesh_terms: D000077584:2-Methoxyestradiol; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015536:Down-Regulation; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D011237:Predictive Value of Tests; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D004958:Estradiol; D000077584:2-Methoxyestradiol; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: PlGF; catechol-O-methyltransferase; estrogen; pregnancy; sFlt-1