title: Quantitative analysis of four types of primary glomeropathy by application of a decision forest to ultrasonic and laboratory characteristics.
abstract: The aim of this study was to apply a decision forest to analysis of the ultrasound characteristics and laboratory test indices of four types of primary glomerulopathy, and quantitative analysis of the four pathologic types using a combination of these two methods. The decision trees were derived from 41 clinical indices and 5 characteristic sonographic indices obtained for the left kidney. Fifty-six patients who had undergone ultrasound-guided renal biopsy were reviewed retrospectively, and on pathologic examination, the patients were diagnosed with primary glomerulopathy, which includes mesangial proliferative glomerulonephritis, membranous nephropathy, immunoglobulin A nephropathy and minimal change disease. In this study, eight characteristic indicators were correlated with pathologic type in the 56 cases of primary glomerulopathy. The order calculated by decision forests, from high to low, is proteinuria, length of kidney, serum creatinine, plasma albumin, area of kidney, total protein, thickness of renal parenchyma, 24-h urine protein. The glomerulopathy with the highest ++++ proteinuria is membranous nephropathy, which accounts for 39.2% (22/56) of the total sample; this was followed by minimal change disease, mesangial proliferative glomerulonephritis and immunoglobulin A nephropathy. On the basis of our analysis of 41 clinical indices, the key indices for quantitative analysis of primary glomerulonephritis are laboratory tests, and these include urine protein, serum creatinine, plasma albumin, total serum protein and 24-h urine protein. The three key sonographic features are measurement indices: renal length, renal area and renal parenchymal thickness. From the eight characteristic indicators, we observed that with respect to severity (from most severe to least severe), the four types of glomerulopathy are membranous nephropathy, minimal change disease, mesangial proliferative glomerulonephritis and immunoglobulin A nephropathy.
authors.affiliation: Department of Ultrasonography, The First Hospital of Harbin, Harbin, People's Republic of China.
authors.forename: Tian-Chong
authors.initials: TC
authors.lastname: Zhao
authors.affiliation: Department of Ultrasonography, The First Hospital of Harbin, Harbin, People's Republic of China. Electronic address: syycsk@163.com.
authors.forename: Jin-Yu
authors.initials: JY
authors.lastname: Wu
authors.affiliation: Department of Ultrasonography, The First Hospital of Harbin, Harbin, People's Republic of China.
authors.forename: Rui-Nan
authors.initials: RN
authors.lastname: Li
authors.affiliation: Department of Ultrasonography, The First Hospital of Harbin, Harbin, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001798:Blood Proteins; D003404:Creatinine / Q000097:blood; D003661:Decision Support Techniques; D005260:Female; D005922:Glomerulonephritis, IGA / Q000000981:diagnostic imaging / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009402:Nephrosis, Lipoid / Q000000981:diagnostic imaging / Q000473:pathology; D009929:Organ Size; D011507:Proteinuria; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012709:Serum Albumin; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D003404:Creatinine
keywords: Clinical laboratory indices; Decision forests; Primary glomerulopathy; Renal biopsy; Ultrasonographic characteristics