title: Mechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties.
abstract: A striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5HT2C receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D044094:Receptors, Melatonin / Q000819:agonists*; D012702:Serotonin Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D044094:Receptors, Melatonin; D012702:Serotonin Antagonists; C084711:agomelatine; D009281:Naphthalenes