title: Poly(L-lactide) and poly(butylene succinate) immiscible blends: from electrospinning to biologically active materials.
abstract: For the first time the preparation of defect-free fibers from immiscible blends of high molar mass poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) in the whole range of the polyester weight ratios is shown. Electrospinning using the solvent-nonsolvent approach proved most appropriate. Moreover, electrospinning revealed crucial for the obtaining of PLA/PBS materials maintaining integrity. DSC and XRD analyses attested for a plasticizing effect and for increased PLA crystallinity at PBS addition to PLA. The mechanical properties of the PLA/PBS mats were controlled by the alignment of the fibers and changed from plastic to brittle materials upon increasing the PBS content. Drug loading and tests against pathogenic microorganisms suggested that the obtained mats can find application as antibacterial fibrous materials.
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
authors.forename: Nikoleta
authors.initials: N
authors.lastname: Stoyanova
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
authors.forename: Dilyana
authors.initials: D
authors.lastname: Paneva
authors.affiliation: Laboratory of Polymeric and Composite Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons - UMONS, Place du Parc 20, B-7000 Mons, Belgium.
authors.forename: Rosica
authors.initials: R
authors.lastname: Mincheva
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
authors.forename: Antoniya
authors.initials: A
authors.lastname: Toncheva
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
authors.forename: Nevena
authors.initials: N
authors.lastname: Manolova
authors.affiliation: Laboratory of Polymeric and Composite Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons - UMONS, Place du Parc 20, B-7000 Mons, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dubois
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria. Electronic address: rashkov@polymer.bas.bg.
authors.forename: Iliya
authors.initials: I
authors.lastname: Rashkov
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002072:Butylene Glycols / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D009600:Nitroquinolines / Q000737:chemistry / Q000494:pharmacology; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000892:Anti-Infective Agents, Urinary; D001672:Biocompatible Materials; D002072:Butylene Glycols; D004337:Drug Carriers; D009600:Nitroquinolines; D011091:Polyesters; D011108:Polymers; C089797:bionole; D019344:Lactic Acid; C033616:poly(lactide); C005308:nitroxoline
keywords: Biological activity; Crystallinity; Electrospinning; Mechanical properties; Poly(butylene succinate); Poly(l-lactide)