title: Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex.
abstract: Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
authors.affiliation: Dipartimento di Chimica, Ugo Schiff, Università di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Messori
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
authors.forename: Angela
authors.initials: A
authors.lastname: Casini
authors.affiliation: Dipartimento di Chimica, Ugo Schiff, Università di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gabbiani
authors.affiliation: Mass Spectrometry Centre (CISM), Università di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Michelucci
authors.affiliation: Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 7, 28049 Madrid, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Cubo
authors.affiliation: Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Ríos-Luci
authors.affiliation: Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.affiliation: Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 7, 28049 Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro-Ranninger
authors.affiliation: Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 7, 28049 Madrid, Spain.
authors.forename: Adoracion G
authors.initials: AG
authors.lastname: Quiroga
keywords: DNA and protein interaction; Iodidoplatinum complex; cytotoxicity