title: Increased prevalence of psoriasis in patients with coronary artery disease: results from a case-control study.
abstract: BACKGROUND
  The incidence of myocardial events has been reported to be increased in patients with psoriasis.
  
  
  OBJECTIVE
  To investigate whether psoriasis is an independent risk factor for coronary artery disease (CAD).
  
  
  METHODS
  We compared the prevalence of psoriasis between case patients with a diagnosis of CAD based on coronary angiography findings and control patients with no CAD referred to the emergency surgery department for an acute noncardiovascular condition. Case and control patients were examined for the presence of psoriasis by two dermatologists. The prevalence of psoriasis was compared among patients with CAD according to CAD severity. Five-hundred cases and 500 age- and sex-matched controls were included.
  
  
  RESULTS
  Using matched univariate analysis, the prevalence of psoriasis was about twofold higher in CAD case patients than in control patients [8·0% vs. 3·4%, odds ratio (OR) 2·64; 95% confidence interval (CI) 1·42-4·88]. Using unconditional multivariate analysis, the association of psoriasis with CAD appeared to be borderline significant (OR 1·84; 95% CI 0·99-3·40). Psoriasis in patients with CAD was significantly associated with three-vessel involvement relative to one-or two-vessel involvement (13·1% vs. 6·1%; OR 3·07; 95% CI 1·50-6·25).
  
  
  CONCLUSIONS
  The prevalence of psoriasis is twofold higher in patients with CAD than in control patients without CAD. It is associated with a more severe coronary artery involvement.
authors.affiliation: Department of Dermatology, Inserm U905, Institute for Research and Innovation in Biomedicine, Rouen University Hospital, University of Normandy, Rouen, France.
authors.forename: D
authors.initials: D
authors.lastname: Picard
authors.forename: J
authors.initials: J
authors.lastname: Bénichou
authors.forename: C
authors.initials: C
authors.lastname: Sin
authors.forename: C
authors.initials: C
authors.lastname: Abasq
authors.forename: E
authors.initials: E
authors.lastname: Houivet
authors.forename: R
authors.initials: R
authors.lastname: Koning
authors.forename: A
authors.initials: A
authors.lastname: Cribier
authors.forename: B
authors.initials: B
authors.lastname: Veber
authors.forename: F
authors.initials: F
authors.lastname: Dujardin
authors.forename: H
authors.initials: H
authors.lastname: Eltchaninoff
authors.forename: P
authors.initials: P
authors.lastname: Joly
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications*; D012307:Risk Factors