title: To identify morbidity and mortality predictors in acute organophosphate poisoning.
abstract: BACKGROUND
  Organophosphorus poisoning remains an important cause of morbidity and mortality, but no definite parameters have been identified as predictors of outcome. Prediction of morbidity at presentation might help in decision making in places of limited resources like rural settings in developing countries.
  
  
  METHODS
  A total of 76 cases were included in this retrospective cohort study. Logged relative risk of requirement of mechanical ventilation and hospital stay >7 days was measured in patients with serum acetylcholinesterase (s. acetylcholinesterase) <1000 versus >1000, presenting in <2 h versus ≥ 2 h after exposure, with Glasgow Coma Scale (GCS) ≤12 versus >12 and in patients with SpO2 <85% versus ≥85% at room air at presentation.
  
  
  RESULTS
  S. acetylcholinesterase <1000, time elapsed after ingestion to presentation ≥ 2 h and SpO2 (at room air) at presentation <85% were found to have positive association with requirement of ventilation. GCS ≤ 12 had a significant association with both requirement of ventilation and hospital stay >7 days.
  
  
  CONCLUSIONS
  S. acetylcholinesterase, SpO2 at room air, GCS, and duration of exposure at presentation can be used to identify the requirement of special care in acute organophosphorus poisoning. This can aid in decision making regarding admission to intensive care unit and referral in the places with limited resources.
authors.affiliation: Department of Medicine, SBKS MI and RC, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
authors.forename: Arti
authors.initials: A
authors.lastname: Muley
authors.affiliation: Department of Anaesthesia, SBKS MI and RC, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
authors.forename: Chaitri
authors.initials: C
authors.lastname: Shah
authors.affiliation: Department of Medicine, SBKS MI and RC, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Lakhani
authors.affiliation: Department of Medicine, SBKS MI and RC, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
authors.forename: Mani
authors.initials: M
authors.lastname: Bapna
authors.affiliation: Department of Medicine, SBKS MI and RC, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
authors.forename: Jigar
authors.initials: J
authors.lastname: Mehta
keywords: Acute organophosphorus poisoning; SpO2; glasgow coma scale; morbidity; serum acetylcholinesterase; time elapsed after exposure