title: Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats.
abstract: OBJECTIVE
  To evaluate the antioxidant and antiperoxidative effects of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 in the third day after tooth extraction in rats.
  
  
  METHODS
  Thirty-two male Wistar rats (270-310 g) were randomly distributed in two groups: Control (n=24) and Test (n=8). Control group was divided into three subgroups (n=8): G1: Sham-Saline; G2: Saline; G3: Isolipid. G1 and G2 animals received NaCl 0.9% while G3 rats were treated with an isolipid mixture (alpha-linolenic acid - ALA) containing -6/-3 oils (8:1 ratio) and-9/-6 (0.4:1 ratio). Test group animals (G4) received oily mixtures (alpha-linolenic acid - ALA, docosahexaenoic acid - DHA, eicosapentaenoic acid - EPA) of -6/-3 (1.4:1 ratio) and -9/-6 (3.4:1 ratio). Saline and oils were administered by gavage during four days before and three days after first mandibular molar extraction. Following, samples (arterial blood and alveolar mucosa) were collected for glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) assays.
  
  
  RESULTS
  Oil mixes induced a significant decrease in GSH and TBARS tissue and plasma concentrations in the third day post-surgery.
  
  
  CONCLUSIONS
  Gavage administration of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats induces a significant decrease in lipid peroxidation.
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Radamés Bezerra
authors.initials: RB
authors.lastname: Melo
authors.affiliation: Department of Surgery, UFC, Fortaleza, CE, Brazil.
authors.forename: Sérgio Botelho
authors.initials: SB
authors.lastname: Guimarães
authors.affiliation: UFC, Fortaleza, CE, Brazil.
authors.forename: Paulo Goberlânio de Barros
authors.initials: PG
authors.lastname: Silva
authors.affiliation: Department of Morphology, UFC, Fortaleza, CE, Brazil.
authors.forename: Reinaldo Barreto
authors.initials: RB
authors.lastname: Oriá
authors.affiliation: Department of Surgery, UFC, Fortaleza, CE, Brazil.
authors.forename: José Ulisses de Souza
authors.initials: JU
authors.lastname: Melo
authors.affiliation: Department of Surgery, UFC, Fortaleza, CE, Brazil.
authors.forename: Paulo Roberto Leitão
authors.initials: PR
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D004338:Drug Combinations; D005227:Fatty Acids / Q000494:pharmacology*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008963:Molar / Q000601:surgery; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013997:Time Factors; D014081:Tooth Extraction / Q000379:methods*; D020390:Tooth Socket / Q000187:drug effects; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione