title: Whole-Body Bone Scan Findings after High-Intensity Focused Ultrasound (HIFU) Treatment.
abstract: OBJECTIVE
  This study aims to examine the findings of (99m)Tc-diphosphonate bone scans in cancer patients with a history of HIFU treatment.
  
  
  METHODS
  Bone scan images of patients with a history of HIFU treatment for primary or metastatic cancer from January 2006 to July 2010 were retrospectively reviewed. Cases of primary bone tumor or HIFU treatment reaching only the superficial soft tissue layer were excluded.
  
  
  RESULTS
  Bone scan images of 62 patients (26 female, 36 male; mean age 57 ± 9 years) were studied. HIFU treatment was performed in the liver (n = 40), pancreas (n = 16), and breast (n = 6). Mean interval time between HIFU treatment and bone scan was 106 ± 105 days (range: 1-572 days). Of 62 scans, 43 showed diffusely decreased uptake of bone within the path of HIFU treatment: antero-axillary and/or posterior arcs of right 5th to 11th ribs in 34 cases after treatment of hepatic lesions; anterior arcs of 2nd to 5th ribs in 5 cases after treatment for breast tumors; and posterior arcs of left 9th to 11th ribs or thoraco-lumbar vertebrae in 4 cases after treatment for pancreas tumor. Of 20 patients who had bone scans more than twice, five showed recovered uptake of the radiotracer in the involved ribs in the follow-up bone scan.
  
  
  CONCLUSIONS
  Of 62 bone scans in patients with a history of HIFU treatment for primary or metastatic cancer, 69% presented diffusely decreased uptake in the bone in the path of HIFU treatment.
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ye Young
authors.initials: YY
authors.lastname: Seo
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: O
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea ; Department of Radiology, Yeouido St. Mary's Hospital, Youngdeungpo-ku Yeouido-dong 62, Seoul, Korea 150-713.
authors.forename: Hyung Sun
authors.initials: HS
authors.lastname: Sohn
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Choi
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ik Dong
authors.initials: ID
authors.lastname: Yoo
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jin Kyoung
authors.initials: JK
authors.lastname: Oh
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Han
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Seung Eun
authors.initials: SE
authors.lastname: Jung
authors.affiliation: Department of Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
keywords: High-intensity focused ultrasound; Photon defect; Whole-body bone scan