title: Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.
abstract: Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
authors.affiliation: Laboratoire de Génétique Moléculaire Humaine, Département de Recherche Scientifique, Institut Pasteur du Maroc, Place Louis Pasteur, 20100, Casablanca, Morocco.
authors.forename: Houda
authors.initials: H
authors.lastname: Benrahma
authors.forename: Hicham
authors.initials: H
authors.lastname: Charoute
authors.forename: Khaled
authors.initials: K
authors.lastname: Lasram
authors.forename: Redouane
authors.initials: R
authors.lastname: Boulouiz
authors.forename: Rym Kefi-Ben
authors.initials: RK
authors.lastname: Atig
authors.forename: Malika
authors.initials: M
authors.lastname: Fakiri
authors.forename: Hassan
authors.initials: H
authors.lastname: Rouba
authors.forename: Sonia
authors.initials: S
authors.lastname: Abdelhak
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Barakat
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D005091:Exons; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D012359:tRNA Methyltransferases; D000099161:Kcnj11 Channel
chemical_list: D051360:Cyclin-Dependent Kinase 5; D024661:Potassium Channels, Inwardly Rectifying; D016601:RNA-Binding Proteins; D012359:tRNA Methyltransferases; D000099161:Kcnj11 Channel; C498779:IGF2BP2 protein, human; C525110:CDKAL1 protein, human