title: Non-cross-bridged tetraazamacrocyclic chelator for stable (64)cu-based radiopharmaceuticals.
abstract: N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with (64)Cu ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator.
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Ajit V
authors.initials: AV
authors.lastname: Dale
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Darpan N
authors.initials: DN
authors.lastname: Pandya
authors.affiliation: Molecular Imaging Research Centre, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science & Technology, Daegu 711-873, South Korea.
authors.forename: Hochun
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Yeong Su
authors.initials: YS
authors.lastname: Ha
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Nikunj
authors.initials: N
authors.lastname: Bhatt
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Jonghee
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science and Clinical Trial Center, Kyungpook National University Graduates School and Hospital , Daegu, South Korea.
authors.forename: Jeong Ju
authors.initials: JJ
authors.lastname: Seo
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Woonghee
authors.initials: W
authors.lastname: Lee
authors.affiliation: Analysis Research Division, Daegu Center, Korea Basic Science Institute , Daegu 702-701, South Korea.
authors.forename: Sung Hong
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science and Clinical Trial Center, Kyungpook National University Graduates School and Hospital , Daegu, South Korea.
authors.forename: Young-Ran
authors.initials: YR
authors.lastname: Yoon
authors.affiliation: Molecular Imaging Research Centre, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
authors.forename: Gwang Il
authors.initials: GI
authors.lastname: An
authors.affiliation: Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
authors.forename: Jeongsoo
authors.initials: J
authors.lastname: Yoo
keywords: Bifunctional chelator; copper complex; imaging agent; radiopharmaceutical