title: One night of partial sleep deprivation affects habituation of hypothalamus and skin conductance responses.
abstract: Sleep disturbances are prevalent in clinical anxiety, but it remains unclear whether they are cause and/or consequence of this condition. Fear conditioning constitutes a valid laboratory model for the acquisition of normal and pathological anxiety. To explore the relationship between disturbed sleep and anxiety in more detail, the present study evaluated the effect of partial sleep deprivation (SD) on fear conditioning in healthy individuals. The neural correlates of 1) nonassociative learning and physiological processing and 2) associative learning (differential fear conditioning) were addressed. Measurements entailed simultaneous functional MRI, EEG, skin conductance response (SCR), and pulse recordings. Regarding nonassociative learning, partial SD resulted in a generalized failure to habituate during fear conditioning, as evidenced by reduced habituation of SCR and hypothalamus responses to all stimuli. Furthermore, SCR and hypothalamus activity were correlated, supporting their functional relationship. Regarding associative learning, effects of partial SD on the acquisition of conditioned fear were weaker and did not reach statistical significance. The hypothalamus plays an integral role in the regulation of sleep and autonomic arousal. Thus sleep disturbances may play a causal role in the development of normal and possibly pathological fear by increasing the susceptibility of the sympathetic nervous system to stressful experiences.
authors.affiliation: Neuroimaging Research Group, Max Planck Institute of Psychiatry, Munich, Germany; and.
authors.forename: Anja C
authors.initials: AC
authors.lastname: Peters
authors.affiliation: Division of Clinical Psychology, Psychotherapy, and Health Psychology, Institute of Psychology, University of Salzburg, Salzburg, Austria.
authors.forename: Jens
authors.initials: J
authors.lastname: Blechert
authors.affiliation: Neuroimaging Research Group, Max Planck Institute of Psychiatry, Munich, Germany; and.
authors.forename: Philipp G
authors.initials: PG
authors.lastname: Sämann
authors.affiliation: Neuroimaging Research Group, Max Planck Institute of Psychiatry, Munich, Germany; and.
authors.forename: Ines
authors.initials: I
authors.lastname: Eidner
authors.affiliation: Neuroimaging Research Group, Max Planck Institute of Psychiatry, Munich, Germany; and.
authors.forename: Michael
authors.initials: M
authors.lastname: Czisch
authors.affiliation: Neuroimaging Research Group, Max Planck Institute of Psychiatry, Munich, Germany; and spoormaker@mpipsykl.mpg.de.
authors.forename: Victor I
authors.initials: VI
authors.lastname: Spoormaker
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology; D001245:Association Learning; D003214:Conditioning, Classical; D005239:Fear; D005260:Female; D005712:Galvanic Skin Response; D006185:Habituation, Psychophysiologic; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D008297:Male; D012892:Sleep Deprivation / Q000503:physiopathology*
keywords: fMRI; fear conditioning; hypothalamus; skin conductance; sleep deprivation