title: Conversion to Paradoxical Finding on Technetium-99m-labeled RBC Scintigraphy after Treatment for Secondary Raynaud's Phenomenon.
abstract: An 18-year-old woman reported that after exposure to cold temperatures her fingers appeared blue and her hands and feet felt cold. Secondary Raynaud's phenomenon (RP) associated with peripheral vascular disease was suspected. Technetium (Tc)-99m-labeled RBC hand scintigraphy after cold change showed decreased blood pool activity in her fingers. The patient's symptoms improved after she received sarpogrelate HCL (200 mg/day) and nifedifine (40 mg/day). Follow-up scintigraphy performed 7 months after the patient started treatment showed paradoxically increased blood pool activity in her fingers after cold challenge. To the best of our knowledge, this is the first case report of a patient with secondary RP showing paradoxical change on scintigraphy after she received medication that improved her symptoms.
authors.affiliation: Department of Nuclear Medicine, Chosun University Hospital, 588 Seoseok-dong, Dong-gu, Gwangju, 501-757 Republic of Korea.
authors.forename: Ari
authors.initials: A
authors.lastname: Chong
authors.affiliation: Department of Nuclear Medicine, Chosun University Hospital, 588 Seoseok-dong, Dong-gu, Gwangju, 501-757 Republic of Korea.
authors.forename: Jung-Min
authors.initials: JM
authors.lastname: Ha
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Ho-Chun
authors.initials: HC
authors.lastname: Song
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Jahae
authors.initials: J
authors.lastname: Kim
authors.affiliation: Division of Transplantation & Vascular Surgery, Department of Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Soo Jin Na
authors.initials: SJ
authors.lastname: Choi
keywords: Paradoxical reaction; Raynaud’s phenomenon; Tc-99 m RBC scintigraphy