title: SeaBase: a multispecies transcriptomic resource and platform for gene network inference.
abstract: Marine and aquatic animals are extraordinarily useful as models for identifying mechanisms of development and evolution, regeneration, resistance to cancer, longevity and symbiosis, among many other areas of research. This is due to the great diversity of these organisms and their wide-ranging capabilities. Genomics tools are essential for taking advantage of these "free lessons" of nature. However, genomics and transcriptomics are challenging in emerging model systems. Here, we present SeaBase, a tool for helping to meet these needs. Specifically, SeaBase provides a platform for sharing and searching transcriptome data. More importantly, SeaBase will support a growing number of tools for inferring gene network mechanisms. The first dataset available on SeaBase is a developmental transcriptomic profile of the sea anemone Nematostella vectensis (Anthozoa, Cnidaria). Additional datasets are currently being prepared and we are aiming to expand SeaBase to include user-supplied data for any number of marine and aquatic organisms, thereby supporting many potentially new models for gene network studies. SeaBase can be accessed online at: http://seabase.core.cli.mbl.edu.
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy*Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: Antje H L
authors.initials: AH
authors.lastname: Fischer
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Mozzherin
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: A Murat
authors.initials: AM
authors.lastname: Eren
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: Kristen D
authors.initials: KD
authors.lastname: Lans
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: Nathan
authors.initials: N
authors.lastname: Wilson
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: Carlo
authors.initials: C
authors.lastname: Cosentino
authors.affiliation: *Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.
authors.forename: Joel
authors.initials: J
authors.lastname: Smith
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000235:genetics*; D019992:Databases as Topic; D053263:Gene Regulatory Networks; D023281:Genomics; D006801:Humans; D012615:Sea Anemones / Q000235:genetics; D059467:Transcriptome