title: Radiotherapy for glomus jugulare paraganglioma.
abstract: Surgery has been long considered to be the treatment of choice for glomus jugulare paragangliomas, as it is the only modality able to totally eradicate the tumour. However, despite considerable progress in interventional radiology and nerve monitoring, surgery is associated with an unacceptably high complication rate for a benign tumour, explaining the growing place of radiotherapy in the management of these tumours. This review of the literature confirms the efficacy of conformal radiotherapy with or without intensity modulation and stereotactic radiotherapy, which both achieve tumour control rates ranging from 90% to almost 100% of cases, but for different tumour volumes, almost constant stabilization or even improvement of symptoms, and a considerably lower rate of adverse effects than with surgery. However, radiotherapy remains contraindicated in the presence of intracranial invasion or extensive osteomyelitis. In the light of these results, together with the improved quality of life and a better knowledge of the natural history of this disease, many authors propose radiotherapy as first-line treatment for all glomus jugulare paragangliomas regardless of their size, particularly in patients with no preoperative deficits.
authors.affiliation: 2, rue Saint-Petersbourg, 75010 Paris, France. Electronic address: patrice.tran-ba-huy@lrb.aphp.fr.
authors.forename: P
authors.initials: P
authors.lastname: Tran Ba Huy
mesh_terms: D005924:Glomus Jugulare; D006801:Humans; D010235:Paraganglioma / Q000532:radiotherapy*; D011878:Radiotherapy / Q000379:methods
keywords: Glomus jugulare paraganglioma; Iatrogenic complications; Radiosurgery; Radiotherapy