title: Radial basis functions for combining shape and speckle tracking in 4D echocardiography.
abstract: Quantitative analysis of left ventricular deformation can provide valuable information about the extent of disease as well as the efficacy of treatment. In this work, we develop an adaptive multi-level compactly supported radial basis approach for deformation analysis in 3D+time echocardiography. Our method combines displacement information from shape tracking of myocardial boundaries (derived from B-mode data) with mid-wall displacements from radio-frequency-based ultrasound speckle tracking. We evaluate our methods on open-chest canines (N=8) and show that our combined approach is better correlated to magnetic resonance tagging-derived strains than either individual method. We also are able to identify regions of myocardial infarction (confirmed by postmortem analysis) using radial strain values obtained with our approach.
authors.forename: Colin B
authors.initials: CB
authors.lastname: Compas
authors.forename: Emily Y
authors.initials: EY
authors.lastname: Wong
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Huang
authors.forename: Smita
authors.initials: S
authors.lastname: Sampath
authors.forename: Ben A
authors.initials: BA
authors.lastname: Lin
authors.forename: Prasanta
authors.initials: P
authors.lastname: Pal
authors.forename: Xenophon
authors.initials: X
authors.lastname: Papademetris
authors.forename: Karl
authors.initials: K
authors.lastname: Thiele
authors.forename: Donald P
authors.initials: DP
authors.lastname: Dione
authors.forename: Mitchel
authors.initials: M
authors.lastname: Stacy
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Staib
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Sinusas
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
authors.forename: James S
authors.initials: JS
authors.lastname: Duncan
mesh_terms: D000465:Algorithms; D000818:Animals; D004285:Dogs; D019561:Echocardiography, Four-Dimensional / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D009068:Movement; D009203:Myocardial Infarction; D009206:Myocardium / Q000473:pathology