title: Two novel alleles HLA-DRB1*11:150 and HLA-DRB1*14:145 identified in Saudi individuals.
abstract: Two new HLA- DRB1 alleles were identified by sequence-based typing method (SBT) in 1100 participants in the Saudi Stem Cell Donor Registry. HLA-DRB1*11:150 differs from HLA-DRB1*11:01:01G by a single C to A substitution at nucleotide position 5580 in exon 2, resulting in an amino acid change from alanine to glutamic acid at position 74. HLA-DRB1*14:145 differs from HLA-DRB1*14:04 by a C to G substitution at nucleotide position 5511 in exon 2, resulting in an amino acid change from threonine to arginine at position 51.
authors.affiliation: Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: H A
authors.initials: HA
authors.lastname: Fakhoury
authors.forename: N
authors.initials: N
authors.lastname: Cereb
authors.forename: D
authors.initials: D
authors.lastname: Jawdat
authors.forename: M
authors.initials: M
authors.lastname: Al Jumah
authors.forename: A S
authors.initials: AS
authors.lastname: Alaskar
authors.forename: A H
authors.initials: AH
authors.lastname: Hajeer
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D001782:Blood Donors; D005091:Exons / Q000235:genetics*; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D012529:Saudi Arabia; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen