title: Curcumin inhibits the invasion of thyroid cancer cells via down-regulation of PI3K/Akt signaling pathway.
abstract: The objectives of this study were to evaluate the in vitro anti-tumor (human thyroid cancer cell lines) potential of curcumin and to elucidate its molecular mechanisms. Here, we investigated the effects of curcumin on the cell viability, apoptosis, migration and invasion of human thyroid cancer cell lines FTC133. We also investigated the effects of curcumin on PI3K, p-Akt, MMP1/7, and COX-2 protein expressions using Western blot. Results showed that curcumin inhibited growth, cell migration and invasion in FTC133, and promoted its apoptosis. Western blot assay data demonstrated that curcumin inhibited phosphorylation of PI3K and Akt signaling pathways and subsequently attenuated MMP1/7 and COX-2 protein expressions in FTC133. In conclusion, curcumin suppresses FTC133 cell invasion and migration by inhibiting PI3K and Akt signaling pathways. Therefore, curcumin produces anti-metastatic activity in FTC133 cells.
authors.affiliation: Department of General Surgery, Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200011, China.
authors.forename: XiaoBo
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of General Surgery, Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200011, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of General Surgery, Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200011, China. Electronic address: dhurnysh@163.com.
authors.forename: WenYong
authors.initials: W
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D015536:Down-Regulation / Q000187:drug effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis; D020783:Matrix Metalloproteinase 7 / Q000096:biosynthesis; D009361:Neoplasm Invasiveness; D019869:Phosphatidylinositol 3-Kinases / Q000096:biosynthesis*; D051057:Proto-Oncogene Proteins c-akt / Q000096:biosynthesis*; D015398:Signal Transduction / Q000187:drug effects; D013964:Thyroid Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1; D003474:Curcumin
keywords: Curcumin; FTC133; PI3K/Akt signaling pathways; Thyroid cancer