title: Unusual redo mitral valve replacement for bleeding in Glanzmann thrombasthenia.
abstract: We report the case of 23-year-old man with mitral valve regurgitation and Glanzmann thrombasthenia, who underwent mechanical mitral valve replacement. Warfarin therapy was devastating, causing bilateral hemothorax, pericardial effusion, gastrointestinal bleeding, and hematuria. Redo mitral valve replacement with a biological prosthesis was required to resolve this critical situation. To our knowledge, this is the first report of mitral valve replacement in Glanzmann thrombasthenia, highlighting the danger of oral anticoagulation in this pathology.
authors.affiliation: Department of Cardiac Surgery, Hospital of Cardiology, UMAE 34, IMSS, Monterrey, Nuevo Leon, Mexico ovidiogv@hotmail.com.
authors.forename: Ovidio A
authors.initials: OA
authors.lastname: Garcia-Villarreal
authors.affiliation: Department of Cardiology, Hospital of Cardiology, UMAE 34, IMSS, Monterrey, Nuevo Leon, Mexico.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fernández-Ceseña
authors.affiliation: Department of Hematology, Hospital of Cardiology, UMAE 34, IMSS, Monterrey, Nuevo Leon, Mexico.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Solano-Ricardi
authors.affiliation: Department of Cardiac Surgery, Hospital of Cardiology, UMAE 34, IMSS, Monterrey, Nuevo Leon, Mexico.
authors.forename: Alma L
authors.initials: AL
authors.lastname: Aguilar-García
authors.affiliation: Department of Cardiac Surgery, Hospital of Cardiology, UMAE 34, IMSS, Monterrey, Nuevo Leon, Mexico.
authors.forename: Raquel
authors.initials: R
authors.lastname: Vega-Hernández
authors.affiliation: Department of Cardiology, Hospital of Cardiology, UMAE 34, IMSS, Monterrey, Nuevo Leon, Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Del Angel-Soto
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001705:Bioprosthesis; D001777:Blood Coagulation / Q000235:genetics; D020878:Device Removal; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D010490:Pericardial Effusion / Q000139:chemically induced; D019106:Postoperative Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D011474:Prosthesis Design; D012086:Reoperation; D012307:Risk Factors; D013915:Thrombasthenia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D014859:Warfarin
keywords: Bioprosthesis; Glanzmann thrombasthenia; Heart valve prothesis implantation; Mitral valve; Thrombasthenia; Warfarin; autosomal dominant