title: Management of peritoneal effusion by sealing with a self-assembling nanofiber polypeptide following pelvic surgery.
abstract: OBJECTIVE
  PuraMatrix is a synthetic material consisting of 16-amino acid peptides that self-assemble into nanofibers, previously used as a scaffold for functional cell cultures. We conducted a clinical study to determine the safety and sealing properties of PuraMatrix in post-operative lymphorrhea following pelvic surgery in humans.
  
  
  METHODS
  A total of 20 patients who underwent rectal cancer resection were analyzed. The study group (n = 10) consisted of patients who received PuraMatrix, matched with a control group (n = 10) of patients operated on conventionally.
  
  
  RESULTS
  During the 2 to 3 month follow-up period, there were no abnormal findings or adverse events in any the patients who received PuraMatrix. We found that the patients who received PuraMatrix had significantly reduced post-operative drainage volumes compared with the patients in the control group.
  
  
  CONCLUSIONS
  PuraMatrix is a safe and effective bio-compatible sealing material for the management of post-operative peritoneal effusion following pelvic surgery.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kondo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Satoru
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Naoya
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000368:Aged; D001202:Ascitic Fluid; D005260:Female; D006489:Hemostatic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D057139:Nanofibers / Q000008:administration & dosage* / Q000009:adverse effects*; D010455:Peptides / Q000008:administration & dosage* / Q000009:adverse effects*; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D058106:Wound Closure Techniques
chemical_list: D010455:Peptides; C546681:RADA16-I