title: New progress in angiogenesis therapy of cardiovascular disease by ultrasound targeted microbubble destruction.
abstract: Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches.
authors.affiliation: Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
authors.forename: Yang-Ying
authors.identifier: 0000-0001-5218-5113
authors.initials: YY
authors.lastname: Liao
authors.affiliation: Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Chen
authors.affiliation: Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
authors.forename: Yi-Xiang
authors.identifier: 0000-0001-5697-0717
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
authors.forename: Yan
authors.identifier: 0000-0002-0713-973X
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.affiliation: Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
authors.forename: Qiu-Lan
authors.initials: QL
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*; D016503:Drug Delivery Systems / Q000379:methods; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D045423:Microbubbles / Q000627:therapeutic use*; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D014465:Ultrasonics / Q000379:methods