title: Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities.
abstract: Bioassay-guided phytochemical investigation of the EtOAc fraction from the leaves of a Chinese medicinal herb, Eucalyptus citriodora Hook, resulted in the isolation of a new compound rhodomyrtosone E (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and X-ray crystallographic analysis. Betulinic acid (2) and corosolic acid (5) increased glucose transporter 4 (GLUT-4) translocation by 2.38 and 1.78-fold, respectively.
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Mei
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Guangzhong
authors.initials: G
authors.lastname: Yang
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: yxzyxz01@163.com.
authors.forename: Xinzhou
authors.initials: X
authors.lastname: Yang
authors.affiliation: Eskitis Institute, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, QLD 4111, Australia. Electronic address: y.feng@griffith.edu.au.
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000818:Animals; D002460:Cell Line; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005052:Eucalyptus / Q000737:chemistry*; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D047188:Chalcones; D051275:Glucose Transporter Type 4; D014966:Xanthenes; C000595510:rhodomyrtosone E
keywords: Antidiabetic; Eucalyptus citriodora; GLUT-4; Triketone–dihydrochalcone conjugate; Triterpenes