title: Cisplatin-induced testicular dysfunction and its amelioration by Launaea taraxacifolia leaf extract.
abstract: This study investigates the ameliorative potential of Launea taraxacifolia (LT) aqueous leaf extract on cisplatin-induced testicular dysfunction in Wistar rats. Thirty rats were randomly divided into six groups (A-F) of 5 rats each: Group A which served as control received water; Group B was intraperitoneally (ip) injected 10 mg kg(-1) body wt cisplatin on day 21; Groups C and D were given 100 and 400 mg of LT via oral administration, respectively, for 21 days while Groups E and F received similar treatment as Groups C and D, respectively, and then exposed to ip administration of 10 mg kg(-1) body weight cisplatin on the 21st day. Exclusively, Cisplatin-exposed Group B rats showed reduced sperm characteristics and increased sperm morphological abnormalities; distorted histological architecture of seminiferous tubules; significantly increased lipid peroxidation (LPO) and decreased activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH)levels in the testes. These parameters in LT alone treated Groups C and D were not markedly different compared with the control group. The rats with the combined treatment in Groups E and F showed significantly improved sperm parameters, testicular histo-architecture and antioxidant enzymatic activities. Conclusively, aqueous extract of L. taraxacifolia has protective potential against cisplatin damage.
authors.affiliation: Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: S A
authors.initials: SA
authors.lastname: Adejuwon
authors.forename: O M
authors.initials: OM
authors.lastname: Femi-Akinlosotu
authors.forename: J O
authors.initials: JO
authors.lastname: Omirinde
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D019659:Asteraceae; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D002945:Cisplatin / Q000633:toxicity*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007248:Infertility, Male / Q000139:chemically induced; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012661:Semen / Q000187:drug effects / Q000378:metabolism; D012671:Seminiferous Tubules / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D013733:Testicular Diseases / Q000139:chemically induced*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D002945:Cisplatin
keywords: Amelioration; Launaea taraxacifolia; antioxidant; cisplatin; testes