title: Amino acid derivatives of adamantane carbocycle are capable of inhibiting replication of highly virulent avian influenza A/H5N1 virus.
abstract: We studied the capacity amino acid derivatives of adamantane to inhibit replication of highly virulent avian influenza A/duck/Novosibirsk/56/05 (H5N1) virus in cultures of swine embryonic kidney cells. Amino acid derivatives of adamantane H-His-Rem and Ad(CH2-Ser-OMe)2 were characterized by lower toxicity than remantadine previously used in the treatment of influenza. Histidine-containing adamantane derivative (H-His-Rem) was the most effective and low-toxic inhibitor of influenza А/H5N1 virus replication and can be recommended for clinical trials to produce a preparation for the treatment and prevention of influenza.
authors.affiliation: D. I. Ivanovskii Research Institute of Virology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.
authors.forename: P G
authors.initials: PG
authors.lastname: Deryabin
authors.forename: T M
authors.initials: TM
authors.lastname: Garaev
authors.forename: M P
authors.initials: MP
authors.lastname: Finogenova
authors.forename: A G
authors.initials: AG
authors.lastname: Botikov
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line; D004622:Embryo, Mammalian; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects* / Q000821:virology; D006639:Histidine / Q000737:chemistry; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000472:pathogenicity* / Q000502:physiology; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000821:virology; D012299:Rimantadine / Q000494:pharmacology; D012694:Serine / Q000737:chemistry; D013552:Swine; D014774:Virulence; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D012299:Rimantadine; D012694:Serine; D006639:Histidine; D000218:Adamantane