title: Acute leukemia of ambiguous lineage with trisomy 4 as the sole cytogenetic abnormality: A case report and literature review.
abstract: We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published cases. Over expression of c-kit, which is localized to chromosome 4, was documented on the leukemic blasts. Prognosis seems to be poor. Treatment with acute lymphoblastic leukemia like regimens seems to be superior compared to acute myeloid leukemia like regimens and allogeneic stem cell transplant is recommended after achieving remission.
authors.affiliation: Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue, El Paso, TX 79905, USA.
authors.forename: S
authors.initials: S
authors.lastname: Moraveji
authors.affiliation: Department of Pathology, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue El Paso, TX 79905, USA.
authors.forename: A
authors.initials: A
authors.lastname: Torabi
authors.affiliation: Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue, El Paso, TX 79905, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Nahleh
authors.affiliation: Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue, El Paso, TX 79905, USA.
authors.forename: S
authors.initials: S
authors.lastname: Farrag
authors.affiliation: Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue, El Paso, TX 79905, USA.
authors.forename: S
authors.initials: S
authors.lastname: Gaur
keywords: Acute leukemia ambiguous lineage; Biphenotypic leukemia; Trisomy 4; c-Kit