title: Leukocyte margination at arteriole shear rate.
abstract: We numerically investigated margination of leukocytes at arteriole shear rate in straight circular channels with diameters ranging from 10 to 22 μm. Our results demonstrated that passing motion of RBCs effectively induces leukocyte margination not only in small channels but also in large channels. A longer time is needed for margination to occur in a larger channel, but once a leukocyte has marginated, passing motion of RBCs occurs continuously independent of the channel diameter, and leukocyte margination is sustained for a long duration. We also show that leukocytes rarely approach the wall surface to within a microvillus length at arteriole shear rate.
authors.affiliation: Department of Biomedical Engineering, Tohoku University, AobaSendai, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Takeishi
authors.affiliation: Department of Bioengineering and Robotics, Tohoku University, AobaSendai, Japan.
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Imai
authors.affiliation: Department of Bioengineering and Robotics, Tohoku University, AobaSendai, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Nakaaki
authors.affiliation: Department of Biomedical Engineering, Tohoku University, AobaSendai, Japan.
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Bioengineering and Robotics, Tohoku University, AobaSendai, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Ishikawa
keywords: Computational biomechanics; leukocyte margination; microcirculation