title: Multiported pulsed valve interface for a linear quadrupole ion trap mass spectrometer to enable rapid screening of multiple functional-group selective ion-molecule reactions.
abstract: Ion-molecule reactions provide a powerful tool for structural elucidation of ionized pharmaceutical analytes in tandem mass spectrometry. However, all previous interfaces for the introduction of reagents for ion-molecule reactions have utilized a single reagent approach. In this study, a multiported pulsed valve system was designed and characterized for rapid introduction of three neutral reagents into a linear quadrupole ion trap. Additionally, automatic triggering was used to allow for the introduction of the reagents on a chromatographic time scale. This system enables automatic, high throughput screening of complex mixtures by using at least three different ion-molecule reactions. Further, rapid testing of new neutral reagents is also possible.
authors.affiliation: Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Jarrell
authors.forename: James
authors.initials: J
authors.lastname: Riedeman
authors.forename: Mark
authors.initials: M
authors.lastname: Carlsen
authors.forename: Randall
authors.initials: R
authors.lastname: Replogle
authors.forename: Tim
authors.initials: T
authors.lastname: Selby
authors.forename: Hilkka
authors.initials: H
authors.lastname: Kenttämaa
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004867:Equipment Design; D057166:High-Throughput Screening Assays / Q000295:instrumentation*; D007202:Indicators and Reagents; D007477:Ions / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation*
chemical_list: D007202:Indicators and Reagents; D007477:Ions