title: Molecular culprits generating brain tumor stem cells.
abstract: Despite current advances in multimodality therapies, such as surgery, radiotherapy, and chemotherapy, the outcome for patients with high-grade glioma remains fatal. Understanding how glioma cells resist various therapies may provide opportunities for developing new therapies. Accumulating evidence suggests that the main obstacle for successfully treating high-grade glioma is the existence of brain tumor stem cells (BTSCs), which share a number of cellular properties with adult stem cells, such as self-renewal and multipotent differentiation capabilities. Owing to their resistance to standard therapy coupled with their infiltrative nature, BTSCs are a primary cause of tumor recurrence post-therapy. Therefore, BTSCs are thought to be the main glioma cells representing a novel therapeutic target and should be eliminated to obtain successful treatment outcomes.
authors.affiliation: School of Life Science and Biotechnology, Korea University, Seoul, Korea.
authors.forename: Se-Yeong
authors.initials: SY
authors.lastname: Oh
authors.affiliation: School of Life Science and Biotechnology, Korea University, Seoul, Korea.
authors.forename: Hyunggee
authors.initials: H
authors.lastname: Kim
keywords: Brain tumor stem cell; Brain tumor stem cell reprogramming; Cancer stem cell niche; High-grade glioma; Reprogramming factors