title: (8RS)-4-Amino-6-(4-chlorophenyl)-8-(2,4-dichlorothiazol-5-yl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine N,N-dimethylformamide monosolvate: sheets built from N-H···N and C-H···O hydrogen bonds.
abstract: In the title compound, C16H11Cl3N6S·C3H7NO, the seven-membered ring adopts a conformation which is close to the twist-boat form. The molecular components are linked into sheets by a combination of two N-H···N hydrogen bonds and two C-H···O hydrogen bonds. Comparisons are made with other aminopyrimidine derivatives.
authors.affiliation: Departamento de Química, Universidad de Valle, AA 25360 Cali, Colombia.
authors.forename: Juan
authors.initials: J
authors.lastname: Ramírez
authors.affiliation: Departamento de Química, Universidad de Valle, AA 25360 Cali, Colombia.
authors.forename: Braulio
authors.initials: B
authors.lastname: Insuasty
authors.affiliation: Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, 23071 Jaén, Spain.
authors.forename: Justo
authors.initials: J
authors.lastname: Cobo
authors.affiliation: School of Chemistry, University of St Andrews, Fife KY16 9ST, Scotland.
authors.forename: Christopher
authors.initials: C
authors.lastname: Glidewell
mesh_terms: D018360:Crystallography, X-Ray; D005559:Formamides / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: C000590236:(8RS)-4-amino-6-(4-chlorophenyl)-8-(2,4-dichlorothiazol-5-yl)-8,9-dihydro-7H-pyrimido(4,5-b)(1,4)diazepine N,N-dimethylformamide; D005559:Formamides; D011743:Pyrimidines
keywords: biological properties; crystal structure; hydrogen bonding; pharmacological properties; pyrimido[4,5-b][1,4]diazepine