title: Increasing maternal percentage body fat in early second trimester: a risk factor for preeclampsia.
abstract: OBJECTIVE
  To determine if maternal percentage body fat (PBF) or fat free mass (FFM) in the early second trimester of pregnancy influenced the development of preeclampsia.
  
  
  METHODS
  A matched nested case-control study was conducted from a cohort study of 1668 women at Gansu provincial maternal and child care hospital from July 2007 to August 2011 in China. Maternal PBF and FFM were assessed by bioelectrical impedance analysis during 12th-16th gestational week. The demographic characteristics were all chart abstracted. After childbirth, 70 cases of preeclampsia were matched by race/age with 140 uncomplicated pregnancies women. Multivariate logistic regression analysis was performed to determine the associated risk factors.
  
  
  RESULTS
  Pre-pregnancy body mass index were higher in women who subsequently developed preeclampsia compared with controls (p < 0.001). During 12th-16th gestational week, there were nearly 7-fold increase in the odds of preeclampsia (adjusted OR: 6.84, 95% CI: 4.15-41.60) among women with PBF ≥ 40% versus women with PBF < 40%. But FFM were not at further increased risk of the development of preeclampsia (adjusted OR, 1.02; 95% CI, 0.6-3.6).
  
  
  CONCLUSIONS
  Maternal PBF but not FFM is a predictor of preeclampsia in the early second trimester. Excessive adipose tissue possibly played an important role in developing of preeclampsia.
authors.affiliation: Department of Maternal and Child Health Care, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China and.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Qiu
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Youjie
authors.initials: Y
authors.lastname: Wang
authors.forename: Yukai
authors.initials: Y
authors.lastname: Du
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000378:metabolism*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000378:metabolism*; D012307:Risk Factors
keywords: Body fat free mass; body fat mass; maternal body compositions; percentage of body fat; preeclampsia