title: 2-Aroylindoles from o-bromochalcones via Cu(I)-catalyzed S(N)Ar with an azide and intramolecular nitrene C-H insertion.
abstract: A simple procedure for the synthesis of 2-aroylindole derivatives comprising a one-pot CuI-catalyzed SNAr reaction of o-bromochalcones with sodium azide and subsequent intramolecular cyclization through nitrene C-H insertion has been developed. This protocol is also applicable with the 2'-bromocinnamates giving the indole-2-carboxylates.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune-411008, India. vr.chepuri@ncl.res.in.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Goriya
authors.forename: Chepuri V
authors.initials: CV
authors.lastname: Ramana
mesh_terms: D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D047188:Chalcones / Q000737:chemistry*; D003300:Copper / Q000494:pharmacology*; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*
chemical_list: D001386:Azides; D047188:Chalcones; D007097:Imines; D007211:Indoles; C017621:phenylnitrene; D003300:Copper