title: Lymphangiogenesis: implications for diagnosis, treatment, and prognosis in patients with melanoma.
abstract: Disease course in melanoma often cannot be accurately predicted by means of the prognostic factors usually considered in patients with melanoma; therefore, new factors are clearly needed. Increasingly robust scientific evidence shows that tumor lymph vessels play a key role in melanoma that metastasizes by lymphatic and hematogenous pathways. We review current knowledge and examine the implications of lymphangiogenesis in the diagnosis, treatment, and prognosis of patients with melanoma.
authors.affiliation: Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. Electronic address: jane.pastushenko@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Pastushenko
authors.affiliation: Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
authors.forename: C
authors.initials: C
authors.lastname: Conejero
authors.affiliation: Facultad de Medicina, Universidad de Zaragoza, Zaragoza, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Carapeto
mesh_terms: D006801:Humans; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011379:Prognosis; D000071036:Sentinel Lymph Node; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*
keywords: Ganglio centinela; Linfangiogénesis; Lymphangiogenesis; Melanoma; Prognosis; Pronóstico; Sentinel lymph node