title: Transfusion-transmitted hepatitis E in Germany, 2013.
abstract: The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.
authors.affiliation: Institute for Virology, University Medical Center, Freiburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Huzly
authors.forename: M
authors.initials: M
authors.lastname: Umhau
authors.forename: D
authors.initials: D
authors.lastname: Bettinger
authors.forename: T
authors.initials: T
authors.lastname: Cathomen
authors.forename: F
authors.initials: F
authors.lastname: Emmerich
authors.forename: P
authors.initials: P
authors.lastname: Hasselblatt
authors.forename: H
authors.initials: H
authors.lastname: Hengel
authors.forename: R
authors.initials: R
authors.lastname: Herzog
authors.forename: O
authors.initials: O
authors.lastname: Kappert
authors.forename: S
authors.initials: S
authors.lastname: Maassen
authors.forename: E
authors.initials: E
authors.lastname: Schorb
authors.forename: C
authors.initials: C
authors.lastname: Schulz-Huotari
authors.forename: R
authors.initials: R
authors.lastname: Thimme
authors.forename: R
authors.initials: R
authors.lastname: Unmüssig
authors.forename: J J
authors.initials: JJ
authors.lastname: Wenzel
authors.forename: M
authors.initials: M
authors.lastname: Panning
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D002648:Child; D016358:Contact Tracing; D005858:Germany; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000097:blood* / Q000635:transmission / Q000821:virology; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D065227:Transfusion Reaction
chemical_list: D000914:Antibodies, Viral; D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D012367:RNA, Viral