title: Polycystic ovary syndrome: implications of metabolic dysfunction.
abstract: OBJECTIVE
  To determine the prevalence of metabolic syndrome (MS) and its clinical interrelations in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This was a cross-sectional, prospective study with 100 patients with diagnosed PCOS based on the consensus of Rotterdam (2003). We investigated the interrelationships of MS, with intrinsic PCOS data. Dermatological profile was analyzed, in addition to acanthosis nigricans (AN) in the presence of hirsutism and acne. The use of HOMA-IR (homeostatic model assessment of insulin resistance) aimed at the correlation with MS in order to establish the metabolic dysfunction with the state of insulin resistance.
  
  
  RESULTS
  The mean and standard deviations corresponding figures for age, body mass index and waist circumference were, respectively, 25.72 (± 4.87), 30.63 (± 9.31) and 92.09 (± 18.73). The prevalence of MS was 36% and significantly correlated with BMI, AN, and in 51% of patients the state of insulin resistance (HOMA-IR). Regarding skin profile, only AN significant correlation with MS.
  
  
  CONCLUSIONS
  We propose the routine inspection of metabolic components related to severe PCOS. These parameters configure the cardiovascular risk and such conduct is of undoubted importance to public health.
authors.affiliation: Department of Obstetrics and Gynecology, Federal University of Rio de Janeiro.
authors.forename: Márcio Augusto Pinto de
authors.initials: MA
authors.lastname: Avila
authors.affiliation: Institute of Gynecology, UFRJ.
authors.forename: Ricardo Vasconcellos
authors.initials: RV
authors.lastname: Bruno
authors.affiliation: Mount Sinai New York Hospital.
authors.forename: Fábio Cuiabano
authors.initials: FC
authors.lastname: Barbosa
authors.affiliation: HUCFF, UFRJ.
authors.forename: Felipe Cupertino de
authors.initials: FC
authors.lastname: Andrade
authors.affiliation: Department of Psychiatry, Fluminense Federal University.
authors.forename: Adriana Cardoso de Oliveira e
authors.initials: AC
authors.lastname: Silva
authors.affiliation: Department of Psychiatry, UFRJ.
authors.forename: Antonio Egídio
authors.initials: AE
authors.lastname: Nardi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism*; D015995:Prevalence; D011446:Prospective Studies