title: Structure-property relationships and biocompatibility of carbohydrate crosslinked polyurethanes.
abstract: Biocompatible and biodegradable polyurethanes (PUs) based on castor oil and polypropylene glycols (PPGs) were prepared using various carbohydrate crosslinkers: monosaccharide (glucose), disaccharide (sucrose) and polysaccharides (starch and cellulose). The mechanical and thermal properties were investigated and interpreted on the basis of SEM study. The advantage of incorporating various carbohydrates is to have tunable mechanical properties and biodegradability due to variety in their structure. The glass transition temperature and sorption behavior were dominated by the type of polyol than by the type of crosslinker. All the PUs were observed to be biodegradable as well as non-cytotoxic as revealed by MTT assay in normal lung cell line L132. The study supports the suitability of carbohydrates as important components of biocompatible PUs for development of biomedical devices.
authors.affiliation: R&D Centre, Gujarat Narmada Valley Fertilizers and Chemicals Company Limited, Bharuch 392 015, India. Electronic address: archu.hrt@gmail.com.
authors.forename: Archana
authors.initials: A
authors.lastname: Solanki
authors.affiliation: R&D Centre, Gujarat Narmada Valley Fertilizers and Chemicals Company Limited, Bharuch 392 015, India.
authors.forename: Jayen
authors.initials: J
authors.lastname: Mehta
authors.affiliation: Department of Chemistry, Faculty of Science, M .S. University of Baroda, Vadodara 390 002, India. Electronic address: drsonalit@gmail.com.
authors.forename: Sonal
authors.initials: S
authors.lastname: Thakore
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D002368:Castor Oil / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000378:metabolism; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D011140:Polyurethanes / Q000737:chemistry* / Q000378:metabolism; D011409:Propylene Glycols / Q000737:chemistry / Q000378:metabolism; D013395:Sucrose / Q000737:chemistry / Q000378:metabolism; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D002241:Carbohydrates; D003432:Cross-Linking Reagents; D011108:Polymers; D011140:Polyurethanes; D011409:Propylene Glycols; C012504:polypropylene glycol; D013395:Sucrose; D002368:Castor Oil; D005947:Glucose
keywords: Biocompatible; Biodegradable; Carbohydrates; Crosslinker; Polyurethanes