title: Triterpene sapogenins with oleanene skeleton: chemotypes and biological activities.
abstract: Critical survey of a selected class of pentacyclic triterpenes--the oleanane family, is presented based on current literature in order to underline their value for medicinal chemistry and drug development potential. Oleanenes may be considered as a renewable resource of valuable research materials which are structurally diverse, inherently biocompatible and have built-in affinity for many categories of functional proteins. Although availability of particular compounds from natural sources may be very low, synthetic methods elaborated by generations of chemists, secure a way to obtaining desirable structures from commercial starting materials.
authors.affiliation: Pharmaceutical Research Institute, Warsaw, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Jatczak
authors.affiliation: Pharmaceutical Research Institute, Warsaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Grynkiewicz
mesh_terms: D006801:Humans; D009828:Oleanolic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D009828:Oleanolic Acid