title: Medium-term outcome of Astra Tech implants in head and neck oncology patients.
abstract: Rehabilitation with implant-retained prostheses is a key step in the rehabilitation of patients after ablative head and neck surgery. Data of patients who underwent mandibular restoration with Astra Tech implants were gathered consecutively and analyzed retrospectively. Implant survival was calculated by Kaplan-Meier analysis, and Cox models were used to identify any association between implant failure and contributing factors. In total, 136 implants were placed in 33 patients. The main reason for ablative surgery was squamous cell carcinoma. Twenty-one patients received adjuvant radiotherapy with a cumulative radiation dose of 56-76Gy prior to implantation. Failure occurred in six patients, resulting in the loss of 17 implants. The cumulative implant survival rate was 92.7% after 1 year and 87.5% after 20 months. Smoking and alcohol consumption were associated with a significantly higher implant failure rate. Most patients had a stable implant status after 20 months.
authors.affiliation: Department of Craniomaxillofacial and Oral Surgery, University Hospital of Zurich, Zürich, Switzerland. Electronic address: Thomas.Gander@usz.ch.
authors.forename: T
authors.initials: T
authors.lastname: Gander
authors.affiliation: Private Practice, Zürich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Studer
authors.affiliation: Department of Radio-oncology, University Hospital of Zürich, Zürich, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Studer
authors.affiliation: Department of Craniomaxillofacial and Oral Surgery, University Hospital of Zurich, Zürich, Switzerland.
authors.forename: K W
authors.initials: KW
authors.lastname: Grätz
authors.affiliation: Department of Craniomaxillofacial and Oral Surgery, University Hospital of Zurich, Zürich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Bredell
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D019232:Dental Restoration Failure; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008297:Male; D008334:Mandible / Q000528:radiation effects / Q000601:surgery; D008875:Middle Aged; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013524:Surgical Flaps; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D015921:Dental Implants
keywords: Astra Tech implants; ablative head and neck surgery; contributing factors; mandible