title: Dual effects of respiratory syncytial virus infections on airway inflammation by regulation of Th17/Treg responses in ovalbumin-challenged mice.
abstract: We investigated the effects of respiratory syncytial virus (RSV) infections on ovalbumin (OVA)-challenged mice via regulation of Th17/Treg cell responses. BALB/c mice were challenged with OVA, followed by RSV infections twice. In OVA-challenged mice, the secretion of Th2/Th17-type cytokines, airway hyperresponsiveness and inflammation were significantly inhibited by initial RSV infection. Moreover, the in vivo findings demonstrated that initial RSV infection reversed the imbalance of Th17/Treg responses. In contrast, RSV re-infection strengthened Th2/Th17-type cytokine secretion, airway hyperresponsiveness, and inflammation, especially for lymphocyte infiltration in OVA-challenged mice. Meanwhile, RSV re-infection enhanced the imbalanced Th17/Treg responses. Upon all results reveal that RSV-induced respiratory infections may lead to dual effects pertaining to allergic airway inflammation by regulation of Th17/Treg responses.
authors.affiliation: Lab of Integrative Medicine for Lung, Inflammation and Cancers, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Lingwen
authors.initials: L
authors.lastname: Kong
authors.forename: Qingli
authors.initials: Q
authors.lastname: Luo
authors.forename: Bei
authors.initials: B
authors.lastname: Li
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wu
authors.forename: Baojun
authors.initials: B
authors.lastname: Liu
authors.forename: Xiao
authors.initials: X
authors.lastname: Wu
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Dong
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D007249:Inflammation; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000633:toxicity*; D011897:Random Allocation; D018357:Respiratory Syncytial Virus Infections / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism*; D012136:Respiratory Syncytial Viruses; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
chemical_list: D010047:Ovalbumin