title: TNF/TNFR: drug target for autoimmune diseases and immune-mediated inflammatory diseases.
abstract: Tumor necrosis factor, a regulatory cytokine, is extremely important signaling protein in the immune system. Among TNF family, TNF-alpha, TNF-beta are most the significant family members. Receptor of TNF namely TNFR1 and TNFR2 stimulates two different signaling pathways. TNFR1 signaling induces apoptosis pathway. Conversely, TNFR2 signaling triggers cell survival pathways. In this paper, we discuss about the TNF family with special reference to TNF-alpha/TNF-beta, different hypothesis related to autoimmunity and role of TNF, structure of TNF-alpha/TNF-beta, distribution and normal activity in human body of TNF, receptors and signaling pathway for drug targeting. Finally, we also discuss about the therapy for autoimmune diseases and immune-mediated inflammatory diseases (IMIDs) using small molecules or therapeutic proteins.
authors.affiliation: Cancer Signaling Laboratory 1, Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: George Priya C
authors.initials: GP
authors.lastname: Doss
authors.affiliation: Cancer Signaling Laboratory 1, Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Agoramoorthy
authors.affiliation: Cancer Signaling Laboratory 1, Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D058990:Molecular Targeted Therapy / Q000379:methods; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000037:antagonists & inhibitors / Q000378:metabolism*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha