title: Interleukin-10 gene promoter polymorphism and susceptibility to liver cirrhosis.
abstract: OBJECTIVE
  Liver cirrhosis is the end-stage of various liver diseases, which has a poor prognosis and determined by deterioration of hepatic functional capacity and consecutive development of hepatic complications. We investigated the role of IL-10-592 A/C, IL-10-819 C/T and IL-10-1082 A/G gene polymorphisms on the development of liver cirrhosis.
  
  
  METHODS
  A 1:2 matched case-control study was conducted, including 266 patients from 302 Military Hospital. Genotyping of IL-10-592 A/C, IL-10-819 C/T and IL-10-1082 A/G were performed in a 384-well plate format on the Sequenom MassARRAY platform.
  
  
  RESULTS
  Multivariate regression analyses showed that subjects carrying the IL-10-592 CC variant had a significant increased risk of liver cirrhosis (OR: 1.83, 95% Cl: 1.10-3.03), and IL-0-592 A/C showed a significant increased risk in recessive model (OR: 1.97, 95% CI: 1.15-3.45). We found those carrying IL-10-592 CC genotype had a heavy increased risk of liver cirrhosis in those with positive chronic hepatitis B, with an OR (95% CI) of 2.46 (1.35-4.42), and a significant interaction was observed between the IL-10-592 A/C genotype and chronic hepatitis B infection (P = 0.036). Those carrying IL-10-819 C/T and IL-10-1082 A/G variants had non-significant increased risk of liver cirrhosis.
  
  
  CONCLUSIONS
  Our study demonstrates that IL-10-592A/C gene polymorphism would enhance the risk for liver cirrhosis, and this gene variant has interaction with chronic hepatitis B infection in Asian population.
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Jin
authors.forename: Ya-Qing
authors.initials: YQ
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Yan
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wang
authors.forename: Song
authors.initials: S
authors.lastname: Qing
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Hong
authors.initials: H
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008103:Liver Cirrhosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D016753:Interleukin-10