title: Mid-trimester maternal ADAM12 levels differ according to fetal gender in pregnancies complicated by preeclampsia.
abstract: An overrepresentation of adverse pregnancy outcomes has been observed in pregnancies associated with a male fetus. We investigated the association between fetal gender and candidate biomarkers for preeclampsia. Proteins were quantified in samples taken at 20 weeks from women recruited to the SCreening fOr Pregnancy Endpoints (SCOPE) study (preeclampsia n = 150; no preeclampsia n = 450). In contrast to placental growth factor, soluble endoglin, and insulin-like growth factor acid labile subunit, levels of metallopeptidase domain 12 (ADAM12) at 20 weeks were dependent on fetal gender in pregnancies complicated by preeclampsia, for male (n = 73) fetuses the multiples of the median (MoM; interquartile range [IQR] 1.1-1.5) was 1.3, whereas for female fetuses (n = 75) MoM was 1.1 (1.0-1.3); P < .01. Prediction of preeclampsia using ADAM12 levels was improved for pregnancies associated with a male fetus (area under receiver-operator curve [AUC] 0.73 [95% confidence interval [CI] 0.67-0.80]) than that of a female fetus (AUC 0.62 [0.55-0.70]); P = .03. The data presented here fit a contemporary hypothesis that there is a difference between the genders in response to an adverse maternal environment and suggest that an alteration in ADAM12 may reflect an altered placental response in pregnancies subsequently complicated by preeclampsia.
authors.affiliation: Maternal & Fetal Heath Research Centre, Manchester Academic Health Science Centre, University of Manchester, Central Manchester NHS Trust, Manchester, United Kingdom jenny.myers@manchester.ac.uk.
authors.forename: Jenny E
authors.initials: JE
authors.lastname: Myers
authors.affiliation: Pronota, Zwijnaarde, Belgium.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Thomas
authors.affiliation: Pronota, Zwijnaarde, Belgium.
authors.forename: Robin
authors.initials: R
authors.lastname: Tuytten
authors.affiliation: Pronota, Zwijnaarde, Belgium.
authors.forename: Yven
authors.initials: Y
authors.lastname: Van Herrewege
authors.affiliation: Pronota, Zwijnaarde, Belgium.
authors.forename: Raoul O
authors.initials: RO
authors.lastname: Djiokep
authors.affiliation: Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
authors.affiliation: The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Ireland.
authors.forename: Louise C
authors.initials: LC
authors.lastname: Kenny
authors.affiliation: Department of Obstetrics and Gynaecology, University of Leeds, Leeds, United Kingdom.
authors.forename: Nigel A B
authors.initials: NA
authors.lastname: Simpson
authors.affiliation: Women's Health Academic Centre, King's College London, London, United Kingdom.
authors.forename: Robyn A
authors.initials: RA
authors.lastname: North
authors.affiliation: Maternal & Fetal Heath Research Centre, Manchester Academic Health Science Centre, University of Manchester, Central Manchester NHS Trust, Manchester, United Kingdom Gravida: National Centre for Growth and Development, Liggins Institute, University of Auckland, New Zealand.
authors.forename: Philip N
authors.initials: PN
authors.lastname: Baker
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000072199:ADAM12 Protein; D000328:Adult; D019540:Area Under Curve; D001315:Australia; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007494:Ireland; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D009520:New Zealand; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000201:enzymology* / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D012732:Sex Determination Analysis; D012737:Sex Factors; D006113:United Kingdom; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; D051722:ADAM Proteins; D000072199:ADAM12 Protein; C000606480:ADAM12 protein, human
keywords: ADAM12; biomarkers; fetal sex; mass spectrometry; preeclampsia