title: Enantioselective Pd-catalyzed allylation of acyclic α-fluorinated ketones.
abstract: Significant synthetic challenges remain for the asymmetric synthesis of tertiary α-fluoro ketones, which are potentially useful molecules for the development of drugs, agrochemicals, and functional materials. Herein, we describe the development of a method for the catalytic enantioselective synthesis of tertiary α-fluoro ketones via the Tsuji-Trost reaction of racemic acyclic α-fluorinated ketones. Enantioenriched acyclic α-cabonyl tertiary fluorides can be produced with the aid of a palladium/phosphinooxazoline catalyst.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, P. R. of China.
authors.forename: Wengui
authors.initials: W
authors.lastname: Wang
authors.forename: Haiming
authors.initials: H
authors.lastname: Shen
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Wan
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
mesh_terms: D002384:Catalysis; D054879:Halogenation; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D010165:Palladium