title: Ovarian cancer biology and immunotherapy.
abstract: Ovarian cancer is the most lethal malignancy of the female reproductive system and the fifth leading cause of cancer death in women. In the year 2012 alone, United States had 22,280 new ovarian cancer cases and 15,500 deaths were reported. About 7%-10% of ovarian cancers result from an inherited tendency to develop the disease. Ovarian cancer has the ability to escape the immune system because of its pathological interactions between cancer cells and host immune cells in the tumor microenvironment create an immunosuppressive network that promotes tumor growth, protects the tumor from immune system. The levels of immune suppressive elements like regulatory T cells, plasmacytoid dendritic cells and cytokines such as IL-10, IL-6, TNF-α, and TGF-β are elevated in the tumor microenvironment. Vascular endothelial growth factor is known to have an immune suppressing role besides its angiogenic role in the tumor microenvironment. Ovarian cancer is associated with high mortality partly due to difficulties in early diagnosis and development of metastases. These problems may overcome by developing accurate mouse models that should mimic the complexity of human ovarian cancer. Such animal models are better suited to understand pathophysiology, metastases, and also for preclinical testing of targeted molecular therapeutics. Immunotherapy is an area of active investigation and off late many clinical trials is ongoing to prevent disease progression. The main aim of dendritic cells vaccination is to stimulate tumor specific effector T cells that can reduce tumor size and induce immunological memory to prevent tumor relapse.
authors.affiliation: 1Department of Genetics & Genomics, Yogi Vemana University, Kadapa, India.
authors.forename: T Sree
authors.initials: TS
authors.lastname: Latha
authors.forename: Kalpana
authors.initials: K
authors.lastname: Panati
authors.forename: D Sravan Kumar
authors.initials: DS
authors.lastname: Gowd
authors.forename: Madhava C
authors.initials: MC
authors.lastname: Reddy
authors.forename: Dakshayani
authors.initials: D
authors.lastname: Lomada
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy / Q000639:trends*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines
keywords: DC vaccines; experimental models; immunotherapy; ovarian cancer; tumor microenvironment