title: A method for evaluation of membrane permeability for water by the erythrocyte osmotic deformability profiles.
abstract: We developed a method for evaluation of membrane permeability for water based on the analysis of osmotic permeability profiles of red blood cells. Deformability of completely spherulated erythrocytes changed in a dose-dependent manner during formation of artificial water pores (by nystatin) and blocking (by HgCl2) of the existing ones.
authors.affiliation: I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, the Russian Academy of Sciences, St. Petersburg, Russia, lion@iephb.ru.
authors.forename: L N
authors.initials: LN
authors.lastname: Katyukhin
mesh_terms: D001692:Biological Transport; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007476:Ionophores / Q000494:pharmacology; D008627:Mercuric Chloride / Q000494:pharmacology; D009761:Nystatin / Q000494:pharmacology; D009995:Osmosis; D014867:Water / Q000378:metabolism*
chemical_list: D007476:Ionophores; D014867:Water; D009761:Nystatin; D008627:Mercuric Chloride