title: Mesalamine-induced myopericarditis in a paediatric patient with Crohn's disease.
abstract: Mesalamine-containing products are considered first-line treatment for inflammatory bowel disease. Myocarditis is recognised as a very rare possible side effect of these medications, but has not often been described in the paediatric population. We present a case of an adolescent with Crohn's disease who presented with myopericarditis after recent initiation of Pentasa. Once identified as the causative agent, the drug was discontinued, with subsequent normalisation of troponin and improvement of function. This case identifies the importance of prompt evaluation, diagnosis, and treatment of paediatric patients receiving mesalamine-containing medications that present with significant cardiovascular symptoms.
authors.affiliation: Division of Cardiology,Children's National Medical Center,Washington,District of Columbia,United States of America.
authors.forename: Asha G
authors.initials: AG
authors.lastname: Nair
authors.affiliation: Division of Cardiology,Children's National Medical Center,Washington,District of Columbia,United States of America.
authors.forename: Russell R
authors.initials: RR
authors.lastname: Cross
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy; D004562:Electrocardiography; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D009205:Myocarditis / Q000097:blood / Q000139:chemically induced*; D010493:Pericarditis / Q000097:blood / Q000139:chemically induced*; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019210:Troponin I; D019804:Mesalamine
keywords: Crohn’s disease