title: Leptin -2548g/a gene polymorphism in association with antipsychotic-induced weight gain: a meta-analysis study.
abstract: BACKGROUND
  The leptin -2548G/A (rs7799039) gene polymorphism has been implicated in susceptibility to antipsychotic-induced weight gain (AIWG), but study results are still controversial. The present meta-analysis was performed to investigate the relationship between the leptin -2548G/A gene polymorphism and AIWG.
  
  
  METHODS
  Electronic databases were searched for eligible articles in English and Chinese and seven separate studies on the association of the leptin -2548G/A gene polymorphism with AIWG were analyzed.
  
  
  RESULTS
  The meta-analysis involved 451 AIWG patients and 568 controls. The pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated by a fixed or random effect. Overall, our meta-analysis suggests that the leptin -2548G/A gene polymorphism was not significantly associated with AIWG risk under various genetic models. But, in the subgroup analysis by ethnicity, significant association was found between leptin -2548A allele and the AIWG risk in Asian populations under additive, dominant, recessive, and homozygote genetic model. On the contrary, in European populations, the -2548A allele seemed to decrease the risk of AIWG when compared with the -2548G allele under various genetic models, even though they were not statistically significant.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that the correlation between leptin -2548G/A gene polymorphism and AIWG risk has significant racial differences.
authors.affiliation: Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Jizhong
authors.initials: J
authors.lastname: Shen
authors.forename: Weihong
authors.initials: W
authors.lastname: Ge
authors.forename: Jinping
authors.initials: J
authors.lastname: Zhang
authors.forename: Huai Jun
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Yun
authors.initials: Y
authors.lastname: Fang
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D006801:Humans; D020738:Leptin / Q000235:genetics*; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; D020738:Leptin