title: Inflammation and glycemic tolerance status in pregnancy: the role of maternal adiposity.
abstract: OBJECTIVE
  Although the association between inflammation and insulin resistance is well known, the data related to the role of inflammation in gestational diabetes mellitus (GDM) are conflicting. The aim of this study was to investigate the association of several inflammatory mediators with the glycemic status in pregnancy.
  
  
  METHODS
  Leukocyte count, ferritin, C-reactive protein (CRP), fibrinogen and interleukin-6 levels were measured in 70 patients with normal glucose tolerance, in 57 patients with impaired glucose tolerance and in 35 patients with GDM as determined based on 50-gram oral glucose tolerance test (OGTT) and 100-gram OGTT results.
  
  
  RESULTS
  A significant difference among the groups was seen only with regard to CRP and fibrinogen levels; however, no significant differences were observed after adjustment for body mass index (BMI). CRP was found to be strongly associated with current BMI in all three groups.
  
  
  CONCLUSIONS
  Maternal serum levels of inflammatory mediators are not related to GDM at the time of the glucose challenge test in the late second or early third trimester. The significant difference in the levels of CRP in different strata of glycemic tolerance was not observed after adjustment for BMI. Adiposity may have a central role in GDM, causing an inflammatory response.
authors.affiliation: Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Şebnem
authors.initials: Ş
authors.lastname: Özyer
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Üstün
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Uzunlar
authors.forename: Ceren
authors.initials: C
authors.lastname: Katar
authors.forename: Nuri
authors.initials: N
authors.lastname: Danışman
mesh_terms: D050154:Adiposity / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003924:Diabetes Mellitus, Type 2; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D015850:Interleukin-6; D007958:Leukocyte Count; D009765:Obesity; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D015850:Interleukin-6; D005340:Fibrinogen; D002097:C-Reactive Protein; D005293:Ferritins