title: Novel lysophosphoplipid receptors: their structure and function.
abstract: It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid. While the roles of some LysoGPs, such as lysophosphatidic acid and sphingosine 1-phosphate, have been thoroughly examined, little is known about the roles of several other LysoGPs, such as lysophosphatidylserine (LysoPS), lysophosphatidylthreonine, lysophosphatidylethanolamine, lysophosphatidylinositol (LPI), and lysophosphatidylglycerol. Recently, a GPCR was found for LPI (GPR55) and three GPCRs (GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3) were found for LysoPS. In this review, we focus on these newly identified GPCRs and summarize the actions of LysoPS and LPI as lipid mediators.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan PRESTO Japan Science and Technology Corporation, Saitama, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Makide
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: Akiharu
authors.initials: A
authors.lastname: Uwamizu
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shinjo
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ishiguro
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Okutani
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan PRESTO Japan Science and Technology Corporation, Saitama, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Inoue
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan CREST, Japan Science and Technology Corporation, Saitama, Japan.
authors.forename: Junken
authors.initials: J
authors.lastname: Aoki
mesh_terms: D000818:Animals; D006801:Humans; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism; D049312:Receptors, Lysophospholipid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D008246:Lysophospholipids; D049312:Receptors, Lysophospholipid
keywords: GPCR; LPI; LysoPS