title: Sudden cardiac death & the Reverse Dodo Verdict.
abstract: Adverse effects of treatment on cardiac QT intervals were first reported 50 years ago. A clear link to sudden death was established, but the problem remained relatively unknown. The issue of treatment related effects on the heart, and the contribution this might make to sudden cardiac deaths in general, came more clearly into focus 20 years ago, linked to regulatory actions. In an era of polypharmacy, and mixing of prescribed and non-prescribed pharmacologically active agents it is now becoming increasingly clear that unanticipated cardiac effects may be common and a significant cause of mortality. There is likely underreporting and also underdiagnosis, as recognition requires a timely ECG. This paper proposes two methods to handle the problem.
authors.affiliation: North Wales Department of Psychological Medicine, Bangor, Wales, UK.
authors.forename: David
authors.initials: D
authors.lastname: Healy
authors.affiliation: North Wales Department of Psychological Medicine, Bangor, Wales, UK.
authors.forename: Gareth
authors.initials: G
authors.lastname: Howe
authors.affiliation: David Braley & Nancy Gordon Chair of Family Medicine, Department of Family Medicine, McMaster University, Hamilton, Canada.
authors.forename: Derelie
authors.initials: D
authors.lastname: Mangin
authors.affiliation: North Wales Department of Psychological Medicine, Bangor, Wales, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Le Noury
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects; D020117:Cisapride / Q000009:adverse effects; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000401:mortality*; D004562:Electrocardiography; D005765:Gastrointestinal Agents / Q000009:adverse effects; D006801:Humans; D012307:Risk Factors; D013881:Thioridazine / Q000009:adverse effects
chemical_list: D014150:Antipsychotic Agents; D005765:Gastrointestinal Agents; D013881:Thioridazine; D020117:Cisapride
keywords: QT intervals; adverse event databases; antidepressants; antipsychotics; cardiac apps; polypharmacy; reverse dodo verdict