title: Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis.
abstract: BACKGROUND
  The Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates. Previous studies have reported the existence of CYP1B1 L432V missense polymorphism in prostate, bladder and renal cancers. However, the effects of this polymorphism on the risk of these cancers remain conflicting. Therefore, we performed a meta-analysis to assess the association between L432V polymorphism and the susceptibility of urinary cancers.
  
  
  METHODS
  We searched the PubMed database without limits on language for studies exploring the relationship of CYP1B1 L432V polymorphism and urinary cancers. Article search was supplemented by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of these associations. Simultaneously, publication bias was estimated by funnel plot and Begg's test with Stata 11 software.
  
  
  RESULTS
  We observed a significant association between CYP1B1 L432V polymorphism and urinary cancers. The overall OR (95% CI) of CC versus CG was 0.937 (0.881-0.996), the overall OR (95% CI) of CC versus CG+GG was 0.942 (0.890-0.997). Furthermore, we identified reduced risk for CC versus other phenotypes in both prostate and overall urinary cancers, when studies were limited to Caucasian or Asian patients.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the CYP1B1 L432V polymorphism is associated with urinary cancer risk.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3108829721231527.
authors.affiliation: Department of Urology, the Second Affiliated Hospital, Nanchang University, Nanchang, China. jiangweifan163@126.com.
authors.forename: Weifan
authors.initials: W
authors.lastname: Jiang
authors.forename: Guang
authors.initials: G
authors.lastname: Sun
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xiong
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Xi
authors.forename: Zimin
authors.initials: Z
authors.lastname: Shi
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D065633:Cytochrome P-450 CYP1B1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D014571:Urologic Neoplasms / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1