title: Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies.
abstract: Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
authors.affiliation: School of Chemistry, ‡School of Cancer Sciences, College of Medical and Dental Sciences, §School of Biosciences, College of Life and Environmental Sciences, and ∥School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham, B15 2TT, U.K.
authors.forename: Huy V
authors.initials: HV
authors.lastname: Nguyen
authors.forename: Antoine
authors.initials: A
authors.lastname: Sallustrau
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Bedford
authors.forename: John C
authors.initials: JC
authors.lastname: Eden
authors.forename: Niki
authors.initials: N
authors.lastname: Georgousi
authors.forename: Nikolas J
authors.initials: NJ
authors.lastname: Hodges
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kedge
authors.forename: Youcef
authors.initials: Y
authors.lastname: Mehellou
authors.forename: Chris
authors.initials: C
authors.lastname: Tselepis
authors.forename: James H R
authors.initials: JH
authors.lastname: Tucker
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D005296:Ferrous Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D000075163:Metallocenes; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D009705:Nucleosides; D009942:Organometallic Compounds; C004998:ferrocene