title: Serum magnesium concentration is inversely associated with fibroblast growth factor 23 in haemodialysis patients.
abstract: OBJECTIVE
  Fibroblast growth factor 23 is reported to be a pivotal regulator for the chronic kidney disease-mineral bone disorders, working in coordinated ways with phosphate, calcium, and parathyroid hormone. However, whether there is a relationship between fibroblast growth factor 23 and magnesium is currently unclear. To address this, we performed a cross-sectional observational study in haemodialysis patients.
  
  
  METHODS
  We measured the serum levels of fibroblast growth factor 23, magnesium and other factors that are implicated in chronic kidney disease-mineral bone disorders in 225 haemodialysis patients.
  
  
  RESULTS
  Simple correlation analysis showed that fibroblast growth factor 23 was not correlated with magnesium. However, upon multiple regression analysis, a significant negative correlation was found between fibroblast growth factor 23 and magunesium (b = -0.164, P = 0.0020). Moreover, the levels of fibroblast growth factor 23 in patients treated with magnesium oxide had significantly lower levels than those without magnesium oxide.
  
  
  CONCLUSIONS
  We speculate that the magnesium is a potential regulator of fibroblast growth factor 23 levels in haemodialysis patients. Our data suggest that follow-up studies to elucidate the molecular mechanisms that underlie this relationship are warranted.
authors.affiliation: Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Iguchi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Noriaki
authors.initials: N
authors.lastname: Iino
authors.forename: Junichiro James
authors.initials: JJ
authors.lastname: Kazama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iesato
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
mesh_terms: D000368:Aged; D001847:Bone Diseases / Q000097:blood / Q000150:complications; D003430:Cross-Sectional Studies; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy*
chemical_list: D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D008274:Magnesium
keywords: Fibroblast growth factor 23; haemodialysis; magnesium oxide; parathyroid hormone; vitamin D