title: [Adverse effects of antiepileptic drugs].
abstract: Adverse effects of antiepileptic drugs are classified into idiosyncratic adverse effects, pharmacology-related adverse effects and biological effect after modification of seizure frequencies. Pharmacology-related adverse effects include those by administered AED and those by mutual interactions. Stevens-Johnson syndrome, one of the idiosyncratic adverse effects, may be predicted by the intrinsic HLA type (e.g., A*31:01 for CBZ). In epileptic patients after acute encephalitis, cutaneous adverse reactions usually occur in a month after encephalitis, but some patients will tolerate the causative AED by the extremely slow re-introduction. Prevention of pharmacology-related adverse effects needs therapeutic drug monitoring, and slow introduction considering dose-response curves for AEDs. Genotype examination of CYP2C9 and 2C19 can contribute to the safe introduction of PHT.
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Watanabe
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Yoshitomi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Tokito
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000741:Anemia, Aplastic / Q000139:chemically induced / Q000517:prevention & control; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control; D065731:Cytochrome P-450 CYP2C19; D065729:Cytochrome P-450 CYP2C9; D016903:Drug Monitoring; D004660:Encephalitis / Q000139:chemically induced / Q000517:prevention & control; D005838:Genotype; D006680:HLA Antigens; D006801:Humans; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000209:etiology / Q000235:genetics / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D006680:HLA Antigens; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19