title: Effect of contraction intensity on sympathetic nerve activity to active human skeletal muscle.
abstract: The effect of contraction intensity on muscle sympathetic nerve activity (MSNA) to active human limbs has not been established. To address this, MSNA was recorded from the left peroneal nerve during and after dorsiflexion contractions sustained for 2 min by the left leg at ~10, 25, and 40% MVC. To explore the involvement of the muscle metaboreflex, limb ischemia was imposed midway during three additional contractions and maintained during recovery. Compared with total MSNA at rest (11.5 ± 4.1 mv(.)min(-1)), MSNA in the active leg increased significantly at the low (21.9 ± 13.6 mv(.)min(-1)), medium (30.5 ± 20.8 mv(.)min(-1)), and high (50.0 ± 24.5 mv(.)min(-1)) intensities. This intensity-dependent effect was more strongly associated with increases in MSNA burst amplitude than burst frequency. Total MSNA then returned to resting levels within the first minute of recovery. Limb ischemia had no significant influence on the intensity-dependent rise in MSNA or its decline during recovery in the active leg. These findings reveal intensity-dependent increases in total MSNA and burst amplitude to contracting human skeletal muscle that do not appear to involve the muscle metaboreflex.
authors.affiliation: School of Science and Health, University of Western Sydney Sydney, NSW, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Boulton
authors.affiliation: School of Science and Health, University of Western Sydney Sydney, NSW, Australia.
authors.forename: Chloe E
authors.initials: CE
authors.lastname: Taylor
authors.affiliation: School of Medicine, University of Western Sydney Sydney, NSW, Australia ; Neuroscience Research Australia Sydney, NSW, Australia.
authors.forename: Vaughan G
authors.initials: VG
authors.lastname: Macefield
authors.affiliation: School of Science and Health, University of Western Sydney Sydney, NSW, Australia ; School of Medicine, University of Western Sydney Sydney, NSW, Australia ; Neuroscience Research Australia Sydney, NSW, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Green
keywords: contraction; ischemia; metaboreflex; muscle; sympathetic