title: Novel biomarker for prostate cancer diagnosis by MRS.
abstract: Magnetic resonance spectroscopy (MRS) is a prospective tool for characterization of the chemical composition of tissues. In vivo MRS can be used for metabolite profiling in the prostate tissue to discriminate non-invasively carcinomas and healthy prostate. In this article different prostate metabolites have been discussed and how to exploit the MRS technique for the estimation of metabolites in prostate tissue quantitatively is elucidated. Choline, citrate, creatine, myo-inositol metabolites can be considered as biomarker for localization of malignancy in the prostate and their ratio can be used for the determination of cancer tissue in the prostate gland.
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Bimal Kumar
authors.initials: BK
authors.lastname: Sarkar
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Kee-Jeong
authors.initials: KJ
authors.lastname: Bae
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: George Priya
authors.initials: GP
authors.lastname: Doss
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Debnarayan
authors.initials: D
authors.lastname: Dutta
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Shangwu
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Bilguun
authors.initials: B
authors.lastname: Ganbold
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Ju-Suk
authors.initials: JS
authors.lastname: Nam
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D019343:Citric Acid / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D019343:Citric Acid; D007294:Inositol; D003401:Creatine; D002794:Choline