title: Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors.
abstract: OBJECTIVE
  To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-affiliated institution.
  
  
  METHODS
  Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013.
  
  
  METHODS
  None.
  
  
  METHODS
  Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities.
  
  
  RESULTS
  Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%.
  
  
  CONCLUSIONS
  Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities.
authors.affiliation: Department of Obstetrics and Gynecology, Mount Sinai St. Luke's-Roosevelt, Icahn School of Medicine at Mount Sinai, New York. Electronic address: mgvega@chpnet.org.
authors.forename: Mario
authors.initials: M
authors.lastname: Vega
authors.affiliation: Department of Obstetrics and Gynecology, Mount Sinai St. Luke's-Roosevelt, Icahn School of Medicine at Mount Sinai, New York.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Breborowicz
authors.affiliation: Department of Community and Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Erin L
authors.initials: EL
authors.lastname: Moshier
authors.affiliation: Department of Obstetrics and Gynecology, Mount Sinai St. Luke's-Roosevelt, Icahn School of Medicine at Mount Sinai, New York.
authors.forename: Peter G
authors.initials: PG
authors.lastname: McGovern
authors.affiliation: Department of Obstetrics and Gynecology, Mount Sinai St. Luke's-Roosevelt, Icahn School of Medicine at Mount Sinai, New York.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Keltz
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001706:Biopsy; D001755:Blastocyst / Q000473:pathology*; D002869:Chromosome Aberrations; D002970:Cleavage Stage, Ovum; D055028:Comparative Genomic Hybridization; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D016014:Linear Models; D011003:Ploidies; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Aneuploidy; PGS; assisted reproduction; embryo quality; preimplantation genetic screening