title: Real world comparison of the MGuard Stent versus the bare metal stent for ST elevation myocardial infarction (the REWARD-MI study).
abstract: OBJECTIVE
  The MGuard Stent (MGS) was designed to prevent distal embolization of thrombus and has been shown to improve microcirculation in ST-elevation myocardial infarction (STEMI). However, there are no real world data comparing it with the bare metal stent (BMS). The aim of this study is to determine the efficacy and safety of the MGS in STEMI in the real world compared to the BMS.
  
  
  RESULTS
  In total, 262 patients were included from a single centre, of which 35.9% had an MGS implanted. Two groups of 79 patients were established after propensity score matching, and they were similar in terms of baseline and periprocedural variables. The mean follow-up was 321 ± 12.94 days. There was no difference in mortality (7.6% in both groups), major adverse cardiac events (20.3% vs. 12.7%, P = 0.198), non-cardiac mortality, or non-fatal myocardial infarction (6.3% in both groups). Target lesion revascularization (TLR) was significantly higher in the MGS group (11.4% (9) vs. 1.3% (1) P < 0.01; RR 10.02 [1.23-81.16]).
  
  
  CONCLUSIONS
  Our study is the first to compare the MGS with the BMS in STEMI in the real world, and it also appears to confirm that although the MGS is a safe device in STEMI that is not associated with increased mortality, it is associated with a higher long-term TLR rate. © 2014 Wiley Periodicals, Inc.
authors.affiliation: Haemodynamic and Interventional Cardiology Unit, University Hospital Virgen del Rocío, Seville, Spain.
authors.forename: Agustín
authors.initials: A
authors.lastname: Fernández-Cisnal
authors.forename: B
authors.initials: B
authors.lastname: Cid-Álvarez
authors.forename: B
authors.initials: B
authors.lastname: Álvarez-Álvarez
authors.forename: J M
authors.initials: JM
authors.lastname: Cubero-Gómez
authors.forename: R
authors.initials: R
authors.lastname: Ocaranza-Sánchez
authors.forename: D
authors.initials: D
authors.lastname: López-Otero
authors.forename: P
authors.initials: P
authors.lastname: Souto-Castro
authors.forename: L S
authors.initials: LS
authors.lastname: Díaz de la Llera
authors.forename: R
authors.initials: R
authors.lastname: Trillo-Nouche
authors.forename: J R
authors.initials: JR
authors.lastname: González-Juanatey
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D023903:Coronary Restenosis / Q000209:etiology; D003328:Coronary Thrombosis; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008670:Metals; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016017:Odds Ratio; D057216:Propensity Score; D016016:Proportional Hazards Models; D011474:Prosthesis Design; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008670:Metals
keywords: ST-elevation myocardial infarction; mesh; primary angioplasty; stent; target lesion revascularization