title: Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice.
abstract: An inclusion complex of NaYF4 :Yb(3+) ,Er(3+) upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4 :Yb(3+) ,Er(3+) is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
authors.forename: Swarup Kumar
authors.initials: SK
authors.lastname: Maji
authors.forename: Sivaramapanicker
authors.initials: S
authors.lastname: Sreejith
authors.forename: James
authors.initials: J
authors.lastname: Joseph
authors.forename: Manjing
authors.initials: M
authors.lastname: Lin
authors.forename: Tingchao
authors.initials: T
authors.lastname: He
authors.forename: Yan
authors.initials: Y
authors.lastname: Tong
authors.forename: Handong
authors.initials: H
authors.lastname: Sun
authors.forename: Sidney Wing-Kwong
authors.initials: SW
authors.lastname: Yu
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000009:adverse effects / Q000737:chemistry; D003510:Cyclohexanes / Q000737:chemistry; D005260:Female; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D016513:Mice, SCID; D008954:Models, Biological; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*; D012997:Solvents / Q000737:chemistry; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014867:Water / Q000737:chemistry; D047391:alpha-Cyclodextrins / Q000737:chemistry
chemical_list: D003287:Contrast Media; D003510:Cyclohexanes; D012997:Solvents; D047391:alpha-Cyclodextrins; D014867:Water; C506365:Cyclohexane; C032613:alpha-cyclodextrin
keywords: Er3+; NaYF4:Yb3+; contrast agent; live mice; photoacoustic imaging; upconversion nanoparticles