title: An extensively hydrolysed rice protein-based formula in the management of infants with cow's milk protein allergy: preliminary results after 1 month.
abstract: BACKGROUND
  Guidelines recommend extensively hydrolysed cow's milk protein formulas (eHF) in the treatment of infants diagnosed with cow's milk protein allergy (CMPA). Extensively hydrolysed rice protein infant formulas (eRHFs) have recently become available, and could offer a valid alternative.
  
  
  METHODS
  A prospective trial was performed to evaluate the clinical tolerance of a new eRHF in infants with a confirmed CMPA. Patients were followed for 1 month. Clinical tolerance of the eRHF was evaluated with a symptom-based score (SBS) and growth (weight and length) was monitored.
  
  
  RESULTS
  Thirty-nine infants (mean age 3.4 months, range 0.5-6 months) diagnosed with CMPA were enrolled. All infants tolerated the eRHF and experienced a normal growth.
  
  
  CONCLUSIONS
  In accordance with current guidelines, this eRHF is tolerated by more than 90% of children with proven CMPA with a 95% CI, and is an adequate alternative to cow's milk-based eHF.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT01998074.
authors.affiliation: Universitair KinderZiekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Vandenplas
authors.affiliation: Universitair KinderZiekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: De Greef
authors.affiliation: Universitair KinderZiekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Bruno
authors.initials: B
authors.lastname: Hauser
mesh_terms: D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008297:Male; D016269:Milk Hypersensitivity / Q000178:diet therapy* / Q000209:etiology; D008894:Milk Proteins / Q000009:adverse effects*; D012275:Oryza; D014674:Plant Proteins, Dietary / Q000008:administration & dosage*; D011446:Prospective Studies; D011492:Protein Hydrolysates / Q000008:administration & dosage*
chemical_list: D008894:Milk Proteins; D014674:Plant Proteins, Dietary; D011492:Protein Hydrolysates
keywords: Allergy; Gastroenterology; General Paediatrics; Nutrition