title: Role of miRNAs in bone and their potential as therapeutic targets.
abstract: MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3'-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea. Electronic address: kmkim@snubh.org.
authors.forename: Kyoung Min
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: lsk@yuhs.ac.
authors.forename: Sung-Kil
authors.initials: SK
authors.lastname: Lim
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D049109:Cell Proliferation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs