title: The mean platelet volume is a potential biomarker for cirrhosis in chronic hepatitis B virus infected patients.
abstract: OBJECTIVE
  In recent years, a great interest has been dedicated to the development of noninvasive predictive models to substitute liver biopsy for cirrhosis assessment and follow-up. Our aim was to provide a simple marker for predicting liver cirrhosis in chronic hepatitis B virus (HBV)-infected patients based on routinely available clinical parameters.
  
  
  METHODS
  Three hundred and fifty-four patients with chronic hepatitis B, including 144 with cirrhosis, 210 without cirrhosis, and 68 healthy controls were enrolled in the study. During the study, a blood sample was collected from all cases to examine liver function, renal function, international normalized ratio (INR) and routine hematological testing.
  
  
  RESULTS
  We demonstrated that in the cirrhosis group, mean platelet volume (MPV) values were significantly increased compared with healthy controls and non-cirrhosis group. Multivariate analysis demonstrated that MPV, total bilirubin (TB) and INR were independent predictors for cirrhosis (both P < 0.01).
  
  
  CONCLUSIONS
  MPV is a simple and non-invasive routine laboratory parameters and elevated MPV level might be an independent predictor for cirrhosis in patients with chronic HBV infection.
authors.forename: Xiao Ting
authors.initials: XT
authors.lastname: Qi
authors.forename: Feng
authors.initials: F
authors.lastname: Wan
authors.forename: YuFeng
authors.initials: Y
authors.lastname: Lou
authors.forename: Bo
authors.initials: B
authors.lastname: Ye
authors.forename: Dingqian
authors.initials: D
authors.lastname: Wu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000821:virology*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged
chemical_list: D015415:Biomarkers