title: Usefulness of serum C-reactive protein level for predicting flap complication after performing free microvascular head and neck reconstruction.
abstract: BACKGROUND
  Free microvascular head and neck reconstruction requires minimal complication and safety. However, clinical observation of the wound in head and neck area is very difficult because of its narrow and inaccessible anatomy. Serum C-reactive protein (CRP) level is commonly used as a marker of acute inflammatory response and quantitative test that shows predictable kinetics. Therefore, awareness of natural CRP trend of free microvascular head and neck reconstruction may help in the early diagnosis of postoperative complications. The goal of this study is to describe the time course of serum CRP level and prove the usefulness of CRP as a predictor of postoperative flap wound complication after performing free microvascular reconstruction in head and neck area.
  
  
  METHODS
  Between June 2009 and November 2012, we retrospectively analyzed the data of 25 patients who received free microvascular tissue transfer for head and neck reconstruction at Ajou University Hospital. The characteristics of patients and surgical information were analyzed. From the first day after surgery, CRP levels were daily measured for 2 weeks. The average CRP values were daily calculated for the normal group and the complicated group and compared between each groups. The amount of time taken to reach the peak CRP level and to reach half of the peak was compared.
  
  
  RESULTS
  A total of 25 patients were included in this study. The amount of time taken to reach the peak of the CRP level is significantly less in the normal group (2.9 d) than the complicated group (7 d) (P < 0.001). Furthermore, the amount of time to reach half of the peak was significantly different between groups (7.2 d vs. 10.1 d, respectively, P < 0.05). In the normal group (17/25), there were 14 cases which reached peak CRP level before postoperative day 4. However, in the complicated group (8/25), there was only 1 case which reached peak CRP level before postoperative day 4 (P < 0.05). The complication rate is 32.7 times higher when CRP value reaches peak on or after postoperative day 4 (95% confidence interval, 30.26-35.14; P = 0.002). Patients in the complicated group showed significantly elevated CRP levels compared to those in the normal group at day 6 to 9 and day 12 to 13 (P < 0.05).
  
  
  CONCLUSIONS
  In head and neck reconstructions, the high probability of flap wound complications are indicated through the result of having highest CRP values on or after postoperative day 4, slow normalization of plasma CRP level, and secondary rise in serial CRP values.
authors.affiliation: From the *Department of Plastic and Reconstructive Surgery, Ajou University Hospital, Suwon; †Department of Biomedical Informatics, Ajou University School of Medicine, Suwon; and ‡Department of Biomedical Sciences, Graduate School, Ajou University, Suwon, Korea.
authors.forename: Hyunsuk
authors.initials: H
authors.lastname: Song
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Myong Chul
authors.initials: MC
authors.lastname: Park
authors.forename: Dong Ha
authors.initials: DH
authors.lastname: Park
authors.forename: KiYoung
authors.initials: K
authors.lastname: Lee
authors.forename: Il Jae
authors.initials: IJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D058752:Free Tissue Flaps; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009336:Necrosis / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein