title: [Exercise-induced left bundle branch block with chest pain related to antimalarial prophylaxis with chloroquine].
abstract: Left bundle branch block (LBBB) during exercise can be associated with chest pain. Though this association is mostly correlated with an underlying coronary artery disease, painful LBBB has been described in patients with normal coronary arteries. We report a case of exercise-induced LBBB with typical angina pectoris related to antimalarial prophylaxis with chloroquine in a 66-year old woman with normal coronary arteries, which was reversed after treatment discontinuation. The effect of chloroquine on the electrophysiological properties of nodal cardiac tissue is responsible for this rate-dependent LBBB. Precautions for future antimalarial prophylaxis are also discussed.
authors.affiliation: Hôpital d'instruction des armées Laveran, service de cardiologie, Marseille.
authors.forename: L
authors.initials: L
authors.lastname: Fourcade
authors.affiliation: Hôpital d'instruction des armées Laveran, service de cardiologie, Marseille.
authors.forename: O
authors.initials: O
authors.lastname: Camus
authors.affiliation: Hôpital d'instruction des armées Laveran, service de cardiologie, Marseille.
authors.forename: N
authors.initials: N
authors.lastname: Roche
authors.affiliation: Hôpital d'instruction des armées Laveran, service de cardiologie, Marseille.
authors.forename: M C
authors.initials: MC
authors.lastname: Chenilleau
authors.affiliation: Hôpital d'instruction des armées Laveran, service de cardiologie, Marseille.
authors.forename: J M
authors.initials: JM
authors.lastname: Gil
authors.affiliation: Hôpital d'instruction des armées Laveran, service de cardiologie, Marseille.
authors.forename: P L
authors.initials: PL
authors.lastname: Massoure
mesh_terms: D000368:Aged; D000962:Antimalarials / Q000009:adverse effects*; D002037:Bundle-Branch Block / Q000139:chemically induced*; D018890:Chemoprevention / Q000009:adverse effects; D002637:Chest Pain / Q000209:etiology*; D002738:Chloroquine / Q000009:adverse effects*; D015444:Exercise; D005260:Female; D006801:Humans; D008288:Malaria / Q000517:prevention & control
chemical_list: D000962:Antimalarials; D002738:Chloroquine
keywords: Left bundle branch block; chest pain; chloroquine; exercise