title: Teratoma with malignant transformation: report of three cases and review of the literature.
abstract: Teratoma with malignant transformation is an uncommon, very aggressive germ cell tumor that has undergone transformation of a somatic teratomatous component to a histologic type identical to a somatic malignancy. We review the clinical presentation, imaging appearances, and prognosis of this entity and highlight its aggressive behavior by reporting on three patients with metastatic testicular nonseminomatous germ cell tumor with histologically proved malignant transformation.
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address: fcabral@partners.org.
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Cabral
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Krajewski
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Rosenthal
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Hirsch
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Howard
mesh_terms: D000328:Adult; D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis*; D011379:Prognosis; D013724:Teratoma / Q000175:diagnosis*; D013736:Testicular Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
keywords: Computed tomography; Nonseminomatous germ cell tumor; Teratoma with malignant transformation; Testicular cancer