title: CaV1.2 calcium channels: just cut out to be regulated?
abstract: Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.
authors.affiliation: Centers for Therapeutic Innovation, Pfizer, 1700 Owens Street, San Francisco, CA 94158, USA.
authors.forename: Rachel D
authors.initials: RD
authors.lastname: Groth
authors.affiliation: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Natasha N
authors.initials: NN
authors.lastname: Tirko
authors.affiliation: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address: richard.tsien@nyumc.org.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Tsien
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D005260:Female; D008297:Male; D009474:Neurons / Q000378:metabolism*; D059748:Proteolysis
chemical_list: D020746:Calcium Channels, L-Type