title: Semi-artificial and bioactive ferroxidase with nanoparticles as the active sites.
abstract: Light-chain apoferritin lacks ferroxidase activity, which can be supplemented with Pt-nanoparticles. The hybrid bioinorganic nanoparticle outperforms its heavy-chain pendant in terms of ferroxidase activity, mineralization ability and inhibition resistance. Being active in a cellular environment it regulates the iron homeostasis.
authors.affiliation: CIC nanoGUNE, Tolosa Hiribidea 76, 20018 Donostia-San Sebastian, Spain. l.zhang@nanogune.eu m.knez@nanogune.eu.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: U
authors.initials: U
authors.lastname: Carmona
authors.forename: M
authors.initials: M
authors.lastname: Knez
mesh_terms: D001052:Apoferritins / Q000737:chemistry / Q000378:metabolism*; D018938:Caco-2 Cells; D020134:Catalytic Domain / Q000187:drug effects; D002570:Ceruloplasmin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D010984:Platinum; D001052:Apoferritins; D002570:Ceruloplasmin; D015032:Zinc