title: Interleukin-17 receptor expression on vascular endothelial cells of masses of skeletal extramedullary disease in myeloma patients.
abstract: The goal of the study was to investigate the expression of interleukin-17 (IL-17) and IL-17 receptor (IL-17R) in patients with myeloma bone diseases (MBD) and skeletal extramedullary disease (skeletal EMD). The levels of IL-17 were determined using ELISA. The expression of IL-17R on vascular endothelial cells of bone marrow (BM) and masses of skeletal EMD was detected using immunohistochemistry. The results showed an elevated IL-17 level in BM of BMD and skeletal EMD patients. The microvessel density (MVD) was significantly increased in the masses of skeletal EMD. IL-17R was almost exclusively expressed by endothelial cells, not by myeloma cells in the masses of skeletal EMD patients. We concluded that EMD masses showed increased angiogenesis mediated by IL-17 pathway and in part this may help in myeloma cell-growth under these conditions.
authors.affiliation: Department of Pathology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Jian-Zhu
authors.initials: JZ
authors.lastname: Yang
authors.affiliation: Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address: happys.ok@163.com.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Sun
authors.affiliation: Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Ling-Juan
authors.initials: LJ
authors.lastname: Kong
authors.affiliation: Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Jin-Qiao
authors.initials: JQ
authors.lastname: Zhang
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D053722:Receptors, Interleukin-17 / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: IL-17 receptor; Microvessel density; Multiple myeloma; Myeloma bone diseases; Skeletal extramedullary disease