title: Systemic EBV T-cell lymphoproliferative disease of young adults.
abstract: T/NK cell proliferative EBV associated disease is a rare one which is more common in eastern Asian countries. EBV is originally associated with B cells, and EBV associated T cell lymphoma is so rare. Hence we decided to describe a patient treated with misleading diagnoses such as TB and sarcoidosis for almost two years. The liver was biopsied after admission in this center, and gastric and colonic biopsy was also performed due to gastrointestinal bleeding. Diffuse infiltration of chronic inflammatory cells was seen, especially lymphocytes some of which were atypical. T lymphocyte markers were seen in these cells by immunohistochemical staining. Further studies demonstrated T lymphocytes associated with EBV to be positive which is very rare event. Although going under chemotherapy, there were no response and the patient died.
authors.affiliation: Department of Medicine, Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran University of Medical Sciences, Tehran, Iran. kheyri.zahedin@yahoo.com.
authors.forename: Zahedin
authors.initials: Z
authors.lastname: Kheyri
authors.affiliation: Department of Medicine, Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran University of Medical Sciences, Tehran, Iran Drmojtahedzadeh@gmail.com.
authors.forename: Aydin
authors.initials: A
authors.lastname: Mojtahedzadeh
authors.affiliation: Department of Medicine, Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran University of Medical Sciences, Tehran, Iran Zamani.Farhad@gmail.com.
authors.forename: Farhad
authors.initials: F
authors.lastname: Zamani
authors.affiliation: Department of Medicine, Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran University of Medical Sciences, Tehran, Iran azm790@yahoo.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Zaremehrjerdi
authors.affiliation: Department of Medicine, Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran University of Medical Sciences, Tehran, Iran Pegah.Heidarian@yahoo.com.
authors.forename: Pegah
authors.initials: P
authors.lastname: Babaheidarian
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008111:Liver Function Tests; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008297:Male