title: The characteristics of Bax inhibitor-1 and its related diseases.
abstract: Bax inhibitor-1 (BI-1) is an evolutionarily-conserved endoplasmic reticulum protein. The expression of BI-1 in mammalian cells suppresses apoptosis induced by Bax, a pro-apoptotic member of the Bcl-2 family. BI-1 has been shown to be associated with calcium (Ca(2+)) levels, reactive oxygen species (ROS) production, cytosolic acidification, and autophagy as well as endoplasmic reticulum stress signaling pathways. According to both in vitro and clinical studies, BI-1 promotes the characteristics of cancers. In other diseases, BI-1 has also been shown to regulate insulin resistance, adipocyte differentiation, hepatic dysfunction and depression. However, the roles of BI-1 in these disease conditions are not fully consistent among studies. Until now, the molecular mechanisms of BI-1 have not directly explained with regard to how these conditions can be regulated. Therefore, this review investigates the physiological role of BI-1 through molecular mechanism studies and its application in various diseases.
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: R K
authors.initials: RK
authors.lastname: Yadav
authors.forename: G S
authors.initials: GS
authors.lastname: Jeong
authors.forename: H-R
authors.initials: HR
authors.lastname: Kim
authors.affiliation: (H.-R. Kim) Department of Dental Pharmacology, School of Dentistry, Wonkwang University, Iksan, 570-749, Republic of Korea. hrkimdp@wonkwang.ac.kr.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Chae
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000378:metabolism; D056811:Unfolded Protein Response / Q000502:physiology
chemical_list: D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; D017382:Reactive Oxygen Species; C484209:TMBIM6 protein, human