title: Colloidal particles containing labeling agents and cyclodextrins for theranostic applications.
abstract: This review aims to give to the reader some new light on cyclodextrin (CD)-based theranostic agents in order to complete our recently published review dedicated to CD-particles conjugates in drug delivery systems (Zafar et al., 2014). CDs are biocompatible sugar-based macrocycles used in a wide range of biomedical applications. Here, we mainly focus on fundamental theranostic approaches combining the use of cyclodextrin molecules and colloidal particles as theranostic agents. The system's key features are discussed and a few recent pertinent applications are presented. CDs are used in order to enhance theranostic properties by providing apolar cavities for the encapsulation of hydrophobic moieties. Thus, CD molecules are used to enhance the loading capacity of particles by hosting active molecules. The relevance of CDs in enhancing the labeling properties of particles and the preparation of controlled drug release particles is also highlighted.
authors.affiliation: University of Lyon, F-69622 Lyon, France, University Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 Bd. 11 Novembre 1918, Villeurbanne F-69622, France.
authors.forename: Nadiah
authors.initials: N
authors.lastname: Zafar
authors.affiliation: University of Lyon, F-69622 Lyon, France, University Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 Bd. 11 Novembre 1918, Villeurbanne F-69622, France.
authors.forename: Hatem
authors.initials: H
authors.lastname: Fessi
authors.affiliation: University of Lyon, F-69622 Lyon, France, University Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 Bd. 11 Novembre 1918, Villeurbanne F-69622, France. Electronic address: elaissari@lagep.univ-lyon1.fr.
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Elaissari
mesh_terms: D000818:Animals; D003102:Colloids; D003287:Contrast Media / Q000737:chemistry / Q000627:therapeutic use; D003505:Cyclodextrins / Q000737:chemistry / Q000627:therapeutic use*; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D003102:Colloids; D003287:Contrast Media; D003505:Cyclodextrins; D005290:Ferric Compounds; C000499:ferric oxide; D012822:Silicon Dioxide
keywords: Cyclodextrins; Encapsulation efficiency; Pore control motifs; Release rate; Theranostics