title: Ultrastructural fingerprints of avian influenza A (H7N9) virus in infected human lung cells.
abstract: In this study, we investigated the ultrastructural modifications induced by influenza A (H7N9) virus in human lung epithelial cells. One particular characteristic of H7N9 viral infection is the formation of numerous M1-associated striated tubular structures within the nucleus and the cytoplasm, which have only previously been observed for a limited number of influenza A viruses, notably the 2009 pandemic (H1N1) virus.
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France. Electronic address: olivier.terrier@univ-lyon1.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Terrier
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Carron
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France.
authors.forename: Gaelle
authors.initials: G
authors.lastname: Cartet
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Traversier
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Julien
authors.affiliation: Centre national de référence des virus influenza (région Sud), Laboratoire de Virologie Est, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Valette
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France; Centre national de référence des virus influenza (région Sud), Laboratoire de Virologie Est, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France; VirNext, Faculté de Médecine RTH Laennec, Université Lyon 1, Lyon, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Moules
authors.affiliation: Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France; VirNext, Faculté de Médecine RTH Laennec, Université Lyon 1, Lyon, France. Electronic address: manuel.rosa-calatrava@univ-lyon1.fr.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rosa-Calatrava
mesh_terms: D002460:Cell Line; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004847:Epithelial Cells / Q000648:ultrastructure* / Q000821:virology*; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000648:ultrastructure*; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D016253:Microscopy, Immunoelectron; D008870:Microtubules / Q000648:ultrastructure
keywords: H7N9; Host cellular ultrastructure; Infection fingerprints; Influenza virus; M1; Matrix protein; Orthomyxoviridae; Viruses