title: The relationship between the metabolic syndrome and its components and bone status in postmenopausal women.
abstract: The association between metabolic syndrome (MS) and bone status remains controversial. We aimed to study the relationships between MS, bone mineral density (BMD), and bone metabolism in postmenopausal women.
  
  
  METHODS
  MS was assessed in 218 white postmenopausal women. BMD (lumbar spine and hip) was measured by dual energy X-ray absorptiometry (DXA). Serum carboxyterminal cross-linked telopeptide of type 1 collagen (CTX), undercarboxylated osteocalcin (uOC), bone alkaline phosphate (BAP) and vitamin D were assayed.
  
  
  RESULTS
  Postmenopausal women with MS had a significantly higher lumber spine BMD than women without MS (p < 0.05). A progressive increase of the BMD at both sites with the number of MS components was observed. Bone turnover markers and vitamin D levels were not significantly influenced by the presence of MS. BMD at both sites positively correlated with body mass index (BMI), waist circumference (WC) and glucose in unadjusted analysis. In multiple regression analysis, WC was independently associated with BMD at both sites, while hypertension was associated only with lumbar spine BMD.
  
  
  CONCLUSIONS
  In postmenopausal women, MS is associated with increased lumbar spine BMD and this relation is explained mainly by the higher BMI and WC in the MS group.
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy 2nd Internal Medicine Department Cluj-Napoca Romania.
authors.forename: D
authors.initials: D
authors.lastname: Fodor
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy 5th Internal Medicine Department Cluj-Napoca Romania.
authors.forename: S
authors.initials: S
authors.lastname: Vesa
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy 2nd Internal Medicine Department Cluj-Napoca Romania.
authors.forename: A
authors.initials: A
authors.lastname: Albu
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy Rheumatology Department 2-4 Clinicilor Str 400006 Cluj Napoca Romania.
authors.forename: S
authors.initials: S
authors.lastname: Simon
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy Biochemistry Department Cluj-Napoca Romania.
authors.forename: A
authors.initials: A
authors.lastname: Craciun
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy Rheumatology Department 2-4 Clinicilor Str 400006 Cluj Napoca Romania.
authors.forename: Laura
authors.initials: L
authors.lastname: Muntean
mesh_terms: D015502:Absorptiometry, Photon; D000367:Age Factors; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D015519:Bone Density; D016723:Bone Remodeling; D024042:Collagen Type I / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D017698:Postmenopause / Q000097:blood / Q000378:metabolism*; D014807:Vitamin D / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D014807:Vitamin D; D000469:Alkaline Phosphatase
keywords: bone mineral density; bone turnover markers; metabolic syndrome; postmenopausal women; vitamin D