title: [Correlation of caveolin-1 expression with clinicopathologic features and prognosis in patients with lung adenocarcinoma].
abstract: OBJECTIVE
  To study the expression, clinicopathologic correlation and prognostic significance of caveolin-1 in lung adenocarcinomas(LAC).
  
  
  METHODS
  Immunohistochemical study (EnVision method) for caveolin-1 and TTF-1 was carried out in 185 cases of LAC encountered during the period from 2005 to 2010. The correlation between caveolin-1 expression and various clinicopathologic parameters was analyzed statistically.
  
  
  RESULTS
  The rate of caveolin-1 expression in the 185 cases of LAC was 26.5% (49/185) and significantly lower than that in normal lung tissue (P<0.01). There was also higher rate of caveolin-1 expression in male patients (P=0.004), smokers (P=0.006), tumors larger than 3.5 cm (P=0.048), predominantly solid tumor subtype (P=0.025), high tumor grade (P=0.044), tumors with vascular invasion (P=0.019), lymph node metastasis (P=0.030), recurrence (P=0.021) and high clinical stage (P=0.027). The expression level of caveolin-1 in TTF1-negative cases was significantly higher than that in TTF1-positive cases and caveolin-1 expression also negatively correlated with TTF-1 expression in LAC (r=-0.154, P=0.037). The five-year overall survival rate of patients with caveolin-1 positive tumors was lower than that in caveolin-1 negative group (P<0.01).Univariate analysis indicated the expression level of caveolin-1 and TTF-1 (P<0.01), histologic subtype (P=0.002), tumor grade (P=0.002), tumor size (P=0.009), vascular invasion (P=0.019), lymph node metastasis (P=0.018), recurrence (P=0.032) and clinical stage (P=0.024) correlated with the survival of patients with LAC. COX multivariate analysis revealed that LAC with caveolin-1 positive expression, TTF-1 negative expression and high tumor grade carried a significantly unfavorable prognosis.
  
  
  CONCLUSIONS
  Caveolin-1 expression correlates with histologic subtype, tumor grade, invasiveness and metastatic potential of LAC. The detection of caveolin-1 in LAC is helpful in predicting prognosis.LAC with caveolin-1 expression carries a poor prognosis.
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Qiuyuan
authors.initials: Q
authors.lastname: Xia
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Rusong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China. E-mail: zhouxj3456@126.com.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000231:Adenocarcinoma, Papillary / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018267:Carcinoma, Acinar Cell / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D051242:Caveolin 1 / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D014157:Transcription Factors; D047368:Tumor Burden
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1; D004268:DNA-Binding Proteins; C504003:TTF1 protein, human; D014157:Transcription Factors