title: Surgery and radiation therapy for brain metastases from classic biphasic pulmonary blastoma.
abstract: Pulmonary blastoma, a rare malignant lung tumour, can metastasise to the brain. However, there is no evidence for any effective treatment. The aim of this report is to discuss the treatment options for pulmonary blastoma and confirm the necessity for a pathological diagnosis. A 75-year-old man was admitted with progressive right-sided hemiplegia and aphasia. MRI showed multiple brain tumours. A left frontal lobe lesion was surgically resected, after which he underwent whole brain radiation (30 Gy/10 fractions). He died of an acute exacerbation of interstitial pneumonia. On performing autopsy, partial responses in the brain metastases that had been irradiated were confirmed pathologically. Thus, we present pathological confirmation that surgery and radiation therapy have therapeutic effects on brain metastases from pulmonary blastoma.
authors.affiliation: Department of Internal Medicine, Keio University Hospital, Shinjuku-ku, Tokyo, Japan Department of Internal Medicine, Asahi General Hospital, Asahi, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Kawasaki
authors.affiliation: Department of Neurosurgery, Asahi General Hospital, Asahi, Japan.
authors.forename: Kuniatsu
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Pathology, Asahi General Hospital, Asahi, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine, Asahi General Hospital, Asahi, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Saito
mesh_terms: D000368:Aged; D001706:Biopsy; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods*; D049268:Positron-Emission Tomography; D018202:Pulmonary Blastoma / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed