title: Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease.
abstract: OBJECTIVE
  The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease.
  
  
  METHODS
  Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method.
  
  
  RESULTS
  All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region.
  
  
  CONCLUSIONS
  Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.
authors.affiliation: Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea.
authors.forename: Eugene
authors.initials: E
authors.lastname: Jeong
authors.affiliation: Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea.
authors.forename: Kisoo
authors.initials: K
authors.lastname: Pahk
authors.affiliation: Department of Neurology, Korea University Medical Center, Seoul, Korea.
authors.forename: Chan-Nyoung
authors.initials: CN
authors.lastname: Lee
authors.affiliation: Department of Neurology, Korea University Medical Center, Seoul, Korea.
authors.forename: Kun-Woo
authors.initials: KW
authors.lastname: Park
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea ; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.affiliation: Department of Nuclear Medicine, Korea University Medical Center, Seoul, 136-705 Korea.
authors.forename: Jae Gol
authors.initials: JG
authors.lastname: Choe
keywords: Dopamine transporter (DAT); F-18 FP-CIT PET; Korean statistical probabilistic anatomical map (KSPAM); Parkinson’s disease; Template-based quantitative analysis