title: Time-dependent bioaccumulation of distinct rod-type TiO2 nanoparticles: comparison by crystalline phase.
abstract: A complete understanding of the interaction between nanoparticles and biological systems, including nanoparticle uptake and distribution and the biological responses, could guide the design of safer and more effective nanoparticles than those currently available. In this study, we compared the distribution in mice over time of two rod-type titanium dioxide nanoparticles (TiNPs) that feature distinct phases, anatase (ATO) and brookite (BTO). Surface areas of BTO and ATO were estimated to be 102 and 268 m(2)  g(-1) , respectively, and negative charge on the surface of ATO was higher than that of BTO in deionized water. Both TiNPs were rapidly distributed into tissues after injection. At 4 weeks after injection, both TiNPs were maximally accumulated in the spleen, followed by the liver, but the total accumulation of ATO in tissues measured in this study was more than that of BTO. Moreover, the cellular antioxidant function was similar although the levels of Ti measured in tissues were distinct between the two TiNPs. Based on these results, we suggest that the fate of TiNPs in the body may differ according to the size and surface charge of the TiNPs even when their shape is the same.
authors.affiliation: Department of Molecular Science and Technology, Ajou University, Suwon, Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Park
authors.forename: Gwang-Hee
authors.initials: GH
authors.lastname: Lee
authors.forename: Cheolho
authors.initials: C
authors.lastname: Yoon
authors.forename: Min-Sung
authors.initials: MS
authors.lastname: Kang
authors.forename: Soo Nam
authors.initials: SN
authors.lastname: Kim
authors.forename: Myung-Haing
authors.initials: MH
authors.lastname: Cho
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Dong-Wan
authors.initials: DW
authors.lastname: Kim
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D053768:Metal Nanoparticles / Q000032:analysis*; D051379:Mice; D008813:Mice, Inbred ICR; D010316:Particle Size; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D014025:Titanium / Q000493:pharmacokinetics*
chemical_list: C009495:titanium dioxide; D014025:Titanium
keywords: distribution; nanorods; surface area; surface charge; titanium dioxide nanoparticles; trace elements