title: RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
abstract: Treating insulin resistance and type 2 diabetes in rodents, currently known retinoid X receptor (RXR) agonists induce significant adverse effects. Here we introduce a novel RXR partial agonist CBt-PMN (11b), which shows a potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists. We suggest that RXR partial agonists may be a new class of antitype 2 diabetes drug candidates.
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kakuta
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Yakushiji
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Shinozaki
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Ohsawa
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Shoya
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Yui
authors.initials: Y
authors.lastname: Ohta
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Kawata
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakayama
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hagaya
authors.affiliation: Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan.
authors.forename: Chisa
authors.initials: C
authors.lastname: Fujiwara
authors.affiliation: Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine , 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Makishima
authors.affiliation: Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine , 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Uno
authors.affiliation: Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 562 Nanatsuka-Cho, Shobara, Hiroshima 727-0023, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tai
authors.affiliation: Division of Medical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan.
authors.forename: Ami
authors.initials: A
authors.lastname: Maehara
authors.affiliation: Division of Medical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakayama
authors.affiliation: Division of Medical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Oohashi
authors.affiliation: Kyoto Pharmaceutical University , 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
authors.affiliation: Kyoto Pharmaceutical University , 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
keywords: Nuclear receptors; RXR; partial agonists; type 2 diabetes