title: Functional remediation for patients with bipolar II disorder: improvement of functioning and subsyndromal symptoms.
abstract: Recently, Functional Remediation (FR) has proven to be effective in improving the functional outcome of euthymic bipolar patients. The aim of this study was to test the efficacy of the FR program in a subsample of euthymic bipolar II patients (BPII). A post-hoc analyses were undertaken using data of 53 BPII outpatients who had participated in a multicenter, rater-blind, randomized, controlled trial exploring the efficacy of FR (n=17) as compared with a Psychoeducation group (PSY) (n=19) and a treatment as usual control group (TAU n=17). The primary outcome variable was the functional improvement defined as the mean change in the Functioning Assessment Short Test (FAST) from baseline to endpoint after the intervention. Regarding the treatment effect, data reveal a significant functional improvement from baseline to endpoint, suggestive for an interaction between program pertinence and time (pre-post). Nevertheless, Tukey׳s post-hoc test only revealed a trend in favor of a better outcome for FR when compared to the other two groups. We also found an interaction between program pertinence and time when analysing the subdepressive symptoms, with BPII patients in FR showing a significant reduction when compared to the PSY group. Our results suggest that the FR appears to be effective in improving the overall functional outcome in BPII, as well as in reducing subdepressive symptoms.
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Brisa
authors.initials: B
authors.lastname: Solé
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: C Mar
authors.initials: CM
authors.lastname: Bonnin
authors.affiliation: Gregorio Marañón University General Hospital and Health Research Institute (IISGM), CIBERSAM, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Mayoral
authors.affiliation: FIDMAG Research Foundation Germanes Hospitalàries, CIBERSAM, Barcelona, Spain.
authors.forename: Benedikt L
authors.initials: BL
authors.lastname: Amann
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Imma
authors.initials: I
authors.lastname: Torres
authors.affiliation: Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: González-Pinto
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Jimenez
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona, Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Crespo
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Colom
authors.affiliation: Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Tabarés-Seisdedos
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Reinares
authors.affiliation: Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Ayuso-Mateos
authors.affiliation: Department Clinical Psychology, Hospital Universitari Clínic; Universitat de Barcelona, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Soria
authors.affiliation: Department of Psychiatry, University of Oviedo, CIBERSAM, Spain.
authors.forename: M Paz
authors.initials: MP
authors.lastname: Garcia-Portilla
authors.affiliation: Department of Psychiatry, Ramon y Cajal Hospital, Alcalá University, IRYCIS, CIBERSAM, Madrid, Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Ibañez
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Electronic address: evieta@clinic.ub.es.
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Electronic address: amartiar@clinic.ub.es.
authors.forename: Anabel
authors.initials: A
authors.lastname: Martinez-Aran
authors.affiliation: Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Torrent
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000628:therapy*; D003071:Cognition; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D016037:Single-Blind Method; D016896:Treatment Outcome
keywords: Bipolar II disorder; Cognitive functioning; Cognitive impairment; Cognitive remediation; Subsyndromic depressive symptoms