title: Reticulocytosis and anemia are associated with an increased risk of death and stroke in the newborn cohort of the Cooperative Study of Sickle Cell Disease.
abstract: Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the ages of 1 and 2 years as markers of severe disease. Reticulocytosis was also associated with severe disease. Here, we further analyzed data collected on enrolled CSSCD infants for the predictive value of those markers for stroke and death later in life. Three hundred fifty-four CSSCD subjects were identified who had absolute reticulocyte counts (ARC) measured during infancy (2 to 6 months of age). Infants with higher ARC had significantly increased risk of stroke or death during childhood; lower hemoglobin levels also increased the risk but to a lesser degree than ARC. WBC levels and dactylitis were not predictive of death or stroke. These data suggest that reticulocytosis among asymptomatic infants with sickle cell anemia is associated with an increased risk of death or stroke during childhood.
authors.affiliation: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, D.C., 20010; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., 20037.
authors.forename: Emily Riehm
authors.initials: ER
authors.lastname: Meier
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Wright
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Miller
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000401:mortality*; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D007958:Leukocyte Count; D008297:Male; D011237:Predictive Value of Tests; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000166:cytology; D045262:Reticulocytosis; D012306:Risk; D020521:Stroke / Q000097:blood* / Q000209:etiology / Q000401:mortality*
chemical_list: D006454:Hemoglobins