title: Metals and nonsteroidal anti-inflammatory pharmaceuticals drugs present in water from Madín Reservoir (Mexico) induce oxidative stress in gill, blood, and muscle of common carp (Cyprinus carpio).
abstract: Many toxic xenobiotics that enter the aquatic environment exert their effects through redox cycling. Oxidative stress, which incorporates both oxidative damage and antioxidant defenses, is a common effect induced in organisms exposed to xenobiotics in their environment. The results of the present study aimed to determine the oxidative stress induced in the common carp Cyprinus carpio by contaminants [metals and nonsteroidal anti-inflammatory drugs (NSAIDs)] present in Madín Reservoir. Five sampling stations (SSs), considered to have the most problems due to discharges, were selected. Carp were exposed to water from each SS for 96 h, and the following biomarkers were evaluated in gill, blood, and muscle: hydroperoxide content, lipid peroxidation, protein carbonyl content, and the activity of antioxidant enzymes superoxide dismutase and catalase. Results show that contaminants (metals and NSAIDs) present in water from the different SSs induce oxidative stress. Thus, water in this reservoir is contaminated with xenobiotics that are hazardous to C. carpio, a species consumed by the local human population.
authors.affiliation: Laboratorio de Toxicología Ambiental, Departamento de Farmacia, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón intersección Paseo Tollocan s/n. Col. Residencial Colón, 50120, Toluca, Estado de México, Mexico.
authors.forename: Edgar David
authors.initials: ED
authors.lastname: González-González
authors.forename: Leobardo Manuel
authors.initials: LM
authors.lastname: Gómez-Oliván
authors.forename: Marcela
authors.initials: M
authors.lastname: Galar-Martínez
authors.forename: Patricia
authors.initials: P
authors.lastname: Vieyra-Reyes
authors.forename: Hariz
authors.initials: H
authors.lastname: Islas-Flores
authors.forename: Sandra
authors.initials: S
authors.lastname: García-Medina
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Jiménez-Vargas
authors.forename: Celene
authors.initials: C
authors.lastname: Razo-Estrada
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pérez-Pastén
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D002347:Carps / Q000097:blood / Q000502:physiology*; D005880:Gills / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008670:Metals / Q000633:toxicity*; D008800:Mexico; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D008670:Metals; D014874:Water Pollutants, Chemical; D013482:Superoxide Dismutase