title: Early diagnosis of colorectal cancer in rats with DMH induced carcinogenesis by means of urine autofluorescence analysis.
abstract: Cancer is one of the most highlighted topics of current research. Early detection of this disease allows more effective therapy, hence higher chance of cure. Application of fluorescence spectral techniques into oncological diagnostic is one of the potential alternatives. Chemically induced carcinogenesis in rats is widely used model for exploration of various aspects of colorectal cancer. This study shows value of discriminate analysis of urine fluorescent fingerprint between healthy control group of rats and those with dimethylhydrazine induced early lesions of colorectal cancer. Using fluorescence spectroscopy, significant difference (P < 0.05) between both of group was achieved.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Šteffeková
authors.forename: Anna
authors.initials: A
authors.lastname: Birková
authors.forename: Alojz
authors.initials: A
authors.lastname: Bomba
authors.forename: Mária
authors.initials: M
authors.lastname: Mareková
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000175:diagnosis*; D004127:Dimethylhydrazines / Q000633:toxicity*; D042241:Early Diagnosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014556:Urine
chemical_list: D002273:Carcinogens; D004127:Dimethylhydrazines