title: Evaluation of preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy: preliminary results.
abstract: OBJECTIVE
  Upper air obstruction leads hypoxia, it is also known that S-100B levels increase by glial activations indicate cerebral hypoxic injury. This study aimed to evaluate the preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy.
  
  
  METHODS
  The study comprised 40 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 40 age-gender matched control patients. Blood samples were taken from the patients preoperatively and at four weeks postoperatively. Preoperative and postoperative serum S-100B levels were analyzed.
  
  
  RESULTS
  The serum S-100B levels in the preoperative period were found to be significantly higher compared to those of the control group (p < 0.05). The S-100B levels were significantly decreased in the postoperative period (p < 0.05).
  
  
  CONCLUSIONS
  The development of chronic adenotonsillar hypertrophy would play a role in increased S-100B levels. This indicates that neuronal damage would exists in patients with chronic adenotonsillar hypertrophy.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Harran University, Faculty of Medicine, Sanliurfa, Turkey. drferhat65@hotmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Bozkus
authors.forename: S
authors.initials: S
authors.lastname: Sarıkaya
authors.forename: O
authors.initials: O
authors.lastname: Kocaturk
authors.forename: M
authors.initials: M
authors.lastname: Calik
authors.forename: M
authors.initials: M
authors.lastname: Abuhandan
authors.forename: A
authors.initials: A
authors.lastname: Altintas
authors.forename: B
authors.initials: B
authors.lastname: Koca
authors.forename: O K
authors.initials: OK
authors.lastname: Guler
authors.forename: N
authors.initials: N
authors.lastname: Aksoy
authors.forename: T
authors.initials: T
authors.lastname: Ulas
mesh_terms: D000233:Adenoidectomy; D000234:Adenoids / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000097:blood* / Q000453:epidemiology; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology*; D011184:Postoperative Period; D057234:Preoperative Period; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D014068:Tonsillectomy; D014421:Turkey / Q000453:epidemiology
chemical_list: D064568:S100 Calcium Binding Protein beta Subunit