title: Efficiency of transplantation of human placental/umbilical blood cells to rats with severe spinal cord injury.
abstract: The effects of a single intravenous injection of human umbilical blood were studied on the model of severe spinal cord contusion injury in rats. Rats receiving no umbilical blood (spontaneous recovery) served as the control. All rats exhibited pronounced hind limb paraplegia and autonomic dysfunction of pelvic organs after the injury. Recovery of the hind limb function was evaluated by loading tests and locomotor activity testing in the open field using BBB score for open-field testing. Testing was carried out weekly for 8 weeks after the injury. Open-field testing showed a significant (p < 0.05) increase of the rate and volume of the hind limb motor activity recovery in the groups receiving umbilical blood infusions.
authors.affiliation: Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia, sir1601@mail.ru.
authors.forename: S I
authors.initials: SI
authors.lastname: Ryabov
authors.forename: M A
authors.initials: MA
authors.lastname: Zvyagintseva
authors.forename: E R
authors.initials: ER
authors.lastname: Pavlovich
authors.forename: V A
authors.initials: VA
authors.lastname: Smirnov
authors.forename: A A
authors.initials: AA
authors.lastname: Grin'
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation; D005312:Fetal Blood / Q000166:cytology / Q000502:physiology; D006614:Hindlimb / Q000294:innervation / Q000473:pathology*; D007275:Injections, Intravenous; D007796:Laminectomy; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D012720:Severity of Illness Index; D013119:Spinal Cord Injuries / Q000473:pathology / Q000628:therapy*; D014183:Transplantation, Heterologous; D016896:Treatment Outcome