title: HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.
abstract: T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.
authors.affiliation: Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
authors.forename: Chi-Yuan
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, Taiwan.
authors.forename: Shih-Chi
authors.identifier: 0000-0002-4263-7654
authors.initials: SC
authors.lastname: Su
authors.affiliation: Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
authors.forename: Chi-Hua
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
authors.forename: Shin-Tarng
authors.initials: ST
authors.lastname: Deng
authors.affiliation: Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, Taiwan ; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan ; Department of Dermatology, Keelung Chang Gung Memorial Hospital, No. 222 Maijin Road, Anle District, Keelung City 20448, Taiwan.
authors.forename: Wen-Hung
authors.initials: WH
authors.lastname: Chung
mesh_terms: D000483:Alleles; D000493:Allopurinol / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D015224:Dideoxynucleosides / Q000009:adverse effects; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000209:etiology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D000099227:Abacavir
chemical_list: D000493:Allopurinol; D002220:Carbamazepine; D015224:Dideoxynucleosides; D006680:HLA Antigens; D000099227:Abacavir