title: DLG5 in cell polarity maintenance and cancer development.
abstract: Failure in establishment and maintenance of epithelial cell polarity contributes to tumorigenesis. Loss of expression and function of cell polarity proteins is directly related to epithelial cell polarity maintenance. The polarity protein discs large homolog 5 (DLG5) belongs to a family of molecular scaffolding proteins called Membrane Associated Guanylate Kinases (MAGUKs). As the other family members, DLG5 contains the multi-PDZ, SH3 and GUK domains. DLG5 has evolved in the same manner as DLG1 and ZO1, two well-studied MAGUKs proteins. Just like DLG1 and ZO1, DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton. Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
authors.affiliation: 1. Center for Translational Medicine, the First Affiliated Hospital of Xian Jiaotong University College of Medicine;
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1. Center for Translational Medicine, the First Affiliated Hospital of Xian Jiaotong University College of Medicine;
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: 2. Department of Surgical Oncology, the First Affiliated Hospital of Xian Jiaotong University College of Medicine.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ren
authors.affiliation: 1. Center for Translational Medicine, the First Affiliated Hospital of Xian Jiaotong University College of Medicine;
authors.forename: Peijun
authors.initials: P
authors.lastname: Liu
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D019143:Evolution, Molecular; D051528:Guanylate Kinases / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D005810:Multigene Family / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*
chemical_list: C114461:DLG5 protein, human; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins; D051528:Guanylate Kinases
keywords: DLG5; EMT; cell proliferation; epithelial cell polarity; migration.