title: Sequential episodes of dengue--Puerto Rico, 2005-2010.
abstract: Of 53,633 suspected dengue cases reported to a passive dengue surveillance system in Puerto Rico during 2005-2010, 949 individuals were reported on more than one occasion and 21 had laboratory-confirmed dengue on two separate occasions. Median time between illness episodes was 2.9 years (range: 62 days-5.3 years). Seventeen (81%) individuals with sequential episodes of dengue were male, and seven (33%) were adults. All 21 individuals experienced one episode and seven (33%) individuals experienced both episodes during a large epidemic that occurred in 2010. These observations show that heterotypic dengue virus immunity that protects against illness may have considerable variability but typically does not last longer than 3 years.
authors.forename: Tyler M
authors.initials: TM
authors.lastname: Sharp
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hunsperger
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Muñoz-Jordán
authors.forename: Harold S
authors.initials: HS
authors.lastname: Margolis
authors.forename: Kay M
authors.initials: KM
authors.lastname: Tomashek
mesh_terms: D056704:Adaptive Immunity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D003716:Dengue Virus / Q000235:genetics / Q000302:isolation & purification*; D062665:Epidemiological Monitoring; D005838:Genotype; D006801:Humans; D007223:Infant; D008875:Middle Aged; D011647:Puerto Rico / Q000453:epidemiology; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D012703:Serotyping
chemical_list: D012367:RNA, Viral