title: Enantioselective synthesis of benzazepinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids.
abstract: The first highly enantioselective iso-Pictet-Spengler reaction of C-2-linked o-aminobenzylindoles with trifluoromethyl ketones was developed using chiral spirocyclic phosphoric acids as organocatalysts, which afforded optically active benzazepinoindoles bearing trifluoromethylated quaternary stereocenters.
authors.affiliation: Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China. lxfok@zju.edu.cn.
authors.forename: Xuejian
authors.initials: X
authors.lastname: Li
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.forename: Haorui
authors.initials: H
authors.lastname: Gu
authors.forename: Xufeng
authors.initials: X
authors.lastname: Lin
mesh_terms: D001552:Benzazepines / Q000138:chemical synthesis*; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis*; D008745:Methylation; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001552:Benzazepines; D007211:Indoles; D010756:Phosphoric Acids