title: Airway complication contributing to disseminated fusariosis after lung transplantation.
abstract: Fungal infections are common after lung transplantation. However, disseminated fusariosis is rare and we report the first case of airway complications associated with this infectious process. A 77-year-old Caucasian woman, who was status post left single-lung transplant for emphysema, presented to clinic 8 months after lung transplantation with pleurisy, shortness of breath, and declining lung function. Bronchoscopy showed narrowing of the left anastomotic site with dynamic compression during exhalation. An AERO stent was deployed successfully, but 3 weeks later, her symptoms recurred. Bronchoscopy showed total stent occlusion with thick tenacious mucus. Fusarium solani was isolated from cultures, and a new 1.5 cm skin nodule was found on the anteromedial midportion of the patient's left lower leg. Voriconazole and anidulafungin were started. No evidence of mucus accumulation was seen during a follow-up bronchoscopy. It is likely that Fusarium infection contributed to the initial anastomotic complication as well as to obstruction of the stent. Furthermore, the stent may have contributed to establishment and development of disseminated fusariosis. With antifungal therapy, stent patency was maintained and the patient improved clinically.
authors.affiliation: Texas Transplant Center, University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Terasaki
authors.forename: S K
authors.initials: SK
authors.lastname: Shah
authors.forename: V J
authors.initials: VJ
authors.lastname: Schnadig
authors.forename: V G
authors.initials: VG
authors.lastname: Valentine
mesh_terms: D000368:Aged; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D060585:Fusariosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D065819:Voriconazole / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin; D065819:Voriconazole
keywords: Fusarium; disseminated Fusarium; endobronchial stent complication; fusariosis; lung transplant