title: Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy.
abstract: A novel anti-cancer drug carrier, mesenchymal stem cells (MSCs) encapsulating drug-loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photo sensitizer to tumors by using tumor-affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy.
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019-5251, USA.
authors.forename: Binrui
authors.initials: B
authors.lastname: Cao
authors.forename: Mingying
authors.initials: M
authors.lastname: Yang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xuewei
authors.initials: X
authors.lastname: Qu
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D059630:Mesenchymal Stem Cells; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D004337:Drug Carriers; D017319:Photosensitizing Agents
keywords: cancer; mesenchymal stem cells (MSCs); nanoparticles; photodynamic therapy; photosensitizers