title: Application of proteomics and peptidomics to COPD.
abstract: Chronic obstructive pulmonary disease (COPD) is a complex disorder involving both airways and lung parenchyma, usually associated with progressive and poorly reversible airflow limitation. In order to better characterize the phenotypic heterogeneity and the prognosis of patients with COPD, there is currently an urgent need for discovery and validation of reliable disease biomarkers. Within this context, proteomic and peptidomic techniques are emerging as very valuable tools that can be applied to both systemic and pulmonary samples, including peripheral blood, induced sputum, exhaled breath condensate, bronchoalveolar lavage fluid, and lung tissues. Identification of COPD biomarkers by means of proteomic and peptidomic approaches can thus also lead to discovery of new molecular targets potentially useful to improve and personalize the therapeutic management of this widespread respiratory disease.
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
authors.forename: Girolamo
authors.initials: G
authors.lastname: Pelaia
authors.affiliation: Department of Health Science, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Terracciano
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vatrella
authors.affiliation: Department of Health Science, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Busceti
authors.affiliation: Department of Respiratory Medicine, Second University of Naples, Caserta, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Calabrese
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Stellato
authors.affiliation: Department of Health Science, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
authors.forename: Rocco
authors.initials: R
authors.lastname: Savino
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Maselli
mesh_terms: D018893:Bronchoalveolar Lavage; D006801:Humans; D010455:Peptides / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D012119:Respiration; D013183:Sputum / Q000378:metabolism
chemical_list: D010455:Peptides