title: p38 Mitogen-activated protein kinase is required for electroacupuncture restoration of CD4+/CD8+ homeostasis and cytokine expression in a rodent model of surgical trauma.
abstract: Cumulative evidences addressed that electroacupuncture (EA) was favorably effective in the treatment of trauma stress-induced immunodeficiency and physical disorders. However, the salutary effects of EA under operation trauma conditions mediated via p38 MAPK remain unknown. Hence, our study aimed to further investigate the effects of EA on CD4(+)/CD8(+) homeostasis and cytokine expressions, and evaluate the p38 MAPK signaling regulatory mechanism of EA effects.
authors.affiliation: Department of Anesthesiology, The Third Affiliated Hospital of Harbin Medical University, No. 6 Baojian Rd., Nangang District, Harbin, 150081, Heilongjiang, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Li
authors.forename: Kuo
authors.initials: K
authors.lastname: Gu
authors.forename: Meng
authors.initials: M
authors.lastname: Chi
authors.forename: Xuechao
authors.initials: X
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Gu
authors.forename: Guonian
authors.initials: G
authors.lastname: Wang
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism*; D016827:CD8 Antigens / Q000378:metabolism*; D015671:Electroacupuncture; D005786:Gene Expression Regulation; D006706:Homeostasis; D020935:MAP Kinase Signaling System; D008297:Male; D011183:Postoperative Complications / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D012333:RNA, Messenger; D048051:p38 Mitogen-Activated Protein Kinases