title: Enzymatic preparation of cis and trans-3-amino-4-hydroxytetrahydrofurans and cis-3-amino-4-hydroxypyrrolidines.
abstract: The lipase catalyzed resolution of cis and trans-3-amino-4-hydroxytetrahydrofurans and cis-3-amino-4-hydroxypyrrolidines have been studied. For all the heterocycles, the best enantioselectivity was obtained using Candida antarctica lipases A and B as catalysts in hydrolytic processes. The absolute configuration of the optically pure obtained heterocycles has been assigned.
authors.affiliation: Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo (Asturias), Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Villar-Barro
authors.affiliation: Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo (Asturias), Spain. Electronic address: vgs@uniovi.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor
authors.affiliation: Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo (Asturias), Spain. Electronic address: rbrieva@uniovi.es.
authors.forename: Rosario
authors.initials: R
authors.lastname: Brieva
mesh_terms: D055162:Biocatalysis; D002175:Candida / Q000201:enzymology* / Q000378:metabolism; D005663:Furans / Q000737:chemistry / Q000378:metabolism*; D006868:Hydrolysis; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D005663:Furans; D011759:Pyrrolidines; D008049:Lipase
keywords: 3-amino-4-hydroxypyrrolidine; 3-amino-4-hydroxytetrahydrofuran; Biocatalysis; Enzymatic resolution; Heterocyclic amino alcohols