title: Innate immune system and preeclampsia.
abstract: Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1/Th2/Th17 and regulatory T-cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of PE.
authors.affiliation: Centro de Investigaciones Biomédicas, Faculty of Medicine, Universidad de los Andes , Santiago , Chile.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Perez-Sepulveda
authors.affiliation: Centro de Investigaciones Biomédicas, Faculty of Medicine, Universidad de los Andes , Santiago , Chile.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Torres
authors.affiliation: Centro de Investigaciones Biomédicas, Faculty of Medicine, Universidad de los Andes , Santiago , Chile ; Cells for Cells , Santiago , Chile.
authors.forename: Maroun
authors.initials: M
authors.lastname: Khoury
authors.affiliation: Centro de Investigaciones Biomédicas, Faculty of Medicine, Universidad de los Andes , Santiago , Chile.
authors.forename: Sebastian E
authors.initials: SE
authors.lastname: Illanes
keywords: Th1–Th17; Th2-Treg; immunomodulation; mesenchymal stem cells; preeclampsia