title: Long term outcome of multidrug-resistant TB patients in Fukujuji Hospital in Japan.
abstract: OBJECTIVE
  To present the long-term outcome of multidrug-resistant tuberculosis (MDR TB) patients.
  
  
  METHODS
  An observational study of 291 MDR TB cases that were diagnosed from 1990 to 2011 at the Fukujuji Hospital in Japan.
  
  
  RESULTS
  The frequency of relapse after cure was 3/168 (1.8%) during a mean follow-up of 4.4 years. Among 16 failure cases, eight patients were negative in later years. One case among the nine lost-to-follow-up patients with culture conversion returned 1.5 years later with positive culture.
  
  
  CONCLUSIONS
  Chronic-positive patients remain positive for years and require observation. Lost to follow-up cases may relapse.
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan yoshiyama1962@yahoo.co.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiyama
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Morimoto
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Okumura
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Ogata
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shiraishi
authors.affiliation: Respiratory Diseases Center, Fukujuji Hospital, 3-1-24 Matsuyama Kiyose, Tokyo, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Kudou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D059012:Lost to Follow-Up; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012008:Recurrence; D012189:Retrospective Studies; D013183:Sputum; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000401:mortality*
chemical_list: D000995:Antitubercular Agents
keywords: Japan; Multidrug-resistant tuberculosis; Tuberculosis