title: Impact of obesity and physical activity on functional outcomes in the elderly: data from NHANES 2005-2010.
abstract: OBJECTIVE
  The objective of this study was to (a) to examine whether the association between obesity and physical functioning among older adults is moderated by physical activity (PA) and (b) to test whether this moderating effect varies by gender.
  
  
  METHODS
  Data from adults (aged >60 years) who participated in the National Health and Nutrition Examination Surveys (2005-2010) were analyzed. Using multivariate logistic regression, we estimated the prevalence ratio (PR) of functional limitations and impairment in activities of daily living and instrumental activities of daily living, by body mass index and PA, while adjusting for age, educational level, and a comorbidity index.
  
  
  RESULTS
  The sample included 5,304 subjects (mean age = 70.4 years), and 50.5% were female. Overweight and obesity were associated with higher levels of functional limitations when compared with normal weight individuals regardless of the PA status (PR = 1.47, 95% confidence interval [CI] [1.17, 1.85], and PR = 2.71, 95% CI [2.00, 3.67], respectively) even after adjustment for confounders.
  
  
  CONCLUSIONS
  Overweight and obesity are associated with impairment in functional outcomes irrespective of PA.
authors.affiliation: University at Albany, School of Public Health, State University of New York, Albany, NY, USA Egrubert@albany.edu.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Vásquez
authors.affiliation: Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Batsis
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Cassandra M
authors.initials: CM
authors.lastname: Germain
authors.affiliation: University at Albany, School of Public Health, State University of New York, Albany, NY, USA.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Shaw
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D005260:Female; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008297:Male; D051346:Mobility Limitation; D009043:Motor Activity / Q000502:physiology*; D015999:Multivariate Analysis; D009765:Obesity / Q000503:physiopathology*; D012737:Sex Factors
keywords: ADL; gender; impairment; physical function