title: Syndrome of insulin resistance with acanthosis nigricans, acral hypertrophy and muscle cramps in an adolescent - a rare diagnosis revisited.
abstract: The authors report a 14-y-old boy with insulin resistance, acanthosis nigricans, acral hypertrophy and muscle cramps. While there was a dramatic response of the muscle cramps to phenytoin therapy, some other features of metabolic syndrome did not respond to phenytoin therapy alone.
authors.affiliation: Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Urmi
authors.initials: U
authors.lastname: Ghosh
authors.forename: Maya
authors.initials: M
authors.lastname: Thomas
authors.forename: Sarah
authors.initials: S
authors.lastname: Mathai
mesh_terms: D000052:Acanthosis Nigricans; D000172:Acromegaly; D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D006801:Humans; D006984:Hypertrophy; D007333:Insulin Resistance; D008297:Male; D009120:Muscle Cramp / Q000188:drug therapy; D010672:Phenytoin / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin