title: Peri-transplant psychosocial factors and neutrophil recovery following hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  Multiple psychosocial factors appear to affect cancer progression in various populations; however, research investigating the relationship between psychosocial factors and outcomes following hematopoietic stem cell transplantation (HCT) is scarce. Subject to adverse immunological and psychological conditions, HCT patients may be especially vulnerable to psychosomatic health sequelae; therefore, we studied whether optimism and anxiety influence the pertinent clinical outcome of days to neutrophil engraftment (DTE).
  
  
  METHODS
  54 adults undergoing either autologous or allogeneic HCT completed self-report questionnaires measuring optimism and anxiety. We assessed the association between these psychosocial variables and DTE.
  
  
  RESULTS
  Greater optimism and less anxiety were associated with the favorable outcome of fewer DTE in autologous HCT recipients, though this relationship was no longer significant when reducing the sample size to only subjects who filled out their baseline survey by the time of engraftment.
  
  
  CONCLUSIONS
  Our findings are suggestive that optimism and anxiety may be associated with time to neutrophil recovery in autologous, but not allogeneic, adult HCT recipients. Further investigation in larger, more homogeneous subjects with consistent baseline sampling is warranted.
authors.affiliation: University of Rochester Medical Center, Department of Psychiatry, the Rochester Center for Mind-Body Research, Rochester, New York, United States of America.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Knight
authors.affiliation: University of Rochester Medical Center, Department of Psychiatry, the Rochester Center for Mind-Body Research, Rochester, New York, United States of America.
authors.forename: Jan A
authors.initials: JA
authors.lastname: Moynihan
authors.affiliation: University of Rochester Medical Center, Department of Psychiatry, the Rochester Center for Mind-Body Research, Rochester, New York, United States of America.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Lyness
authors.affiliation: University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, New York, United States of America.
authors.forename: Yinglin
authors.initials: Y
authors.lastname: Xia
authors.affiliation: University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, New York, United States of America.
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.affiliation: University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, New York, United States of America.
authors.forename: Susan
authors.initials: S
authors.lastname: Messing
authors.affiliation: Nazareth College, Department of Music Therapy, Rochester, New York, United States of America.
authors.forename: Bryan C
authors.initials: BC
authors.lastname: Hunter
authors.affiliation: University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, New York, United States of America.
authors.forename: Li-Shan
authors.initials: LS
authors.lastname: Huang
authors.affiliation: University of Rochester Medical Center, Department of Pediatrics, Division of Hematology/Oncology, Rochester, New York, United States of America.
authors.forename: Rosemary O
authors.initials: RO
authors.lastname: Obi
authors.affiliation: University of Rochester Medical Center, Department of Cardiology, Rochester, New York, United States of America.
authors.forename: D'Arcy
authors.initials: D
authors.lastname: Gaisser
authors.affiliation: University of Rochester Medical Center, Department of Medicine, Division of Hematology/Oncology, Rochester, New York, United States of America.
authors.forename: Jane L
authors.initials: JL
authors.lastname: Liesveld
authors.affiliation: University of Rochester Medical Center, Department of Pediatrics, Division of Hematology/Oncology, Rochester, New York, United States of America; University of Rochester Medical Center, Department of Medicine, Division of Hematology/Oncology, Rochester, New York, United States of America; University of Rochester Medical Center, Department of Psychiatry, Rochester, New York, United States of America; University of Rochester Medical Center, Department of Medical Humanities, Rochester, New York, United States of America.
authors.forename: Olle Jane Z
authors.initials: OJ
authors.lastname: Sahler
mesh_terms: D000328:Adult; D001007:Anxiety / Q000523:psychology; D003625:Data Collection; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000378:metabolism*; D013997:Time Factors