title: Efficient diagnosis of Sjögren's syndrome to reduce the burden on patients.
abstract: OBJECTIVE
  The purpose of this study was to investigate the procedures for efficiently diagnosing Sjögren's syndrome to reduce patient burden.
  
  
  METHODS
  This study analyzed data from 254 Japanese patients diagnosed with Sjögren's syndrome out of 4967 who visited our clinic complaining of xerostomia.
  
  
  RESULTS
  Of the 254 Sjögren's syndrome patients, 140 fulfilled the criteria proposed by the Committee on Sjögren's Syndrome of the Ministry of Health and Welfare of Japan, 228 fulfilled the criteria proposed by the American-European Consensus Group, and 69 fulfilled the criteria proposed by the American College of Rheumatology. Numbers of definitive cases varied with each set of criteria. Logistic regression analysis was used to analyze useful examination items for definitive diagnosis of Sjögren's syndrome, demonstrating that anti-Ro/SSA (odds ratio (OR), 7.165), lip biopsy (OR, 4.273), sialography (OR, 2.402), and ANA (OR, 0.678) correlated significantly with definitive diagnosis of Sjögren's syndrome.
  
  
  CONCLUSIONS
  These results suggest that the following diagnostic procedure for Sjögren's syndrome would reduce burden on patients. When clinicians choose examination items for diagnosing Sjögren's syndrome, they should first select which criteria to use. Then, to minimize the number of examination items, examinations should be performed in order of anti-SSA antibody, lip biopsy, and parotid gland sialography.
authors.affiliation: Department of Clinical Pathophysiology, Tsurumi University Dental Hospital , Tsurumi-ku, Yokohama , Japan.
authors.forename: Asumi J
authors.initials: AJ
authors.lastname: Niikura
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yamachika
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Mariko R
authors.initials: MR
authors.lastname: Okamoto
authors.forename: Yuko F
authors.initials: YF
authors.lastname: Ikeda
authors.forename: Sachika
authors.initials: S
authors.lastname: Nakamura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Oda
authors.forename: Takahiro K
authors.initials: TK
authors.lastname: Imamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Saito
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakagawa
mesh_terms: D001323:Autoantibodies / Q000097:blood; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D006801:Humans; D007564:Japan; D012261:Ribonucleoproteins / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D014987:Xerostomia / Q000209:etiology* / Q000276:immunology; D000099207:SS-A Antigen
chemical_list: D001323:Autoantibodies; D012261:Ribonucleoproteins; D000099207:SS-A Antigen
keywords: Anti-SS-A antibody; Diagnostic criteria; Lip biopsy; Parotid sialography; Sjögren's syndrome