title: Method of continuous variation: characterization of alkali metal enolates using ¹H and ¹⁹F NMR spectroscopies.
abstract: The method of continuous variation in conjunction with (1)H and (19)F NMR spectroscopies was used to characterize lithium and sodium enolates solvated by N,N,N',N'-tetramethylethyldiamine (TMEDA) and tetrahydrofuran (THF). A strategy developed using lithium enolates was then applied to the more challenging sodium enolates. A number of sodium enolates solvated by TMEDA or THF afford exclusively tetramers. Evidence suggests that TMEDA chelates sodium on cubic tetramers.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University , Ithaca, New York 14853-1301, United States.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Tomasevich
authors.forename: David B
authors.initials: DB
authors.lastname: Collum
mesh_terms: D005461:Fluorine / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011522:Protons; D012964:Sodium / Q000737:chemistry*
chemical_list: D007659:Ketones; D011522:Protons; D005461:Fluorine; D008094:Lithium; D012964:Sodium