title: Gender differences in metabolic disorders and related diseases in Spontaneously Diabetic Torii-Lepr(fa) rats.
abstract: The Spontaneously Diabetic Torii Lepr(fa) (SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. In this study, we investigated gender differences in abnormalities and related complications in SDT fatty rats. Food intake was higher in males compared to female rats; however, body weight was not different between genders. Progression of diabetes, including increases in blood glucose and declines in blood insulin, was observed earlier in male rats than in females, and diabetic grade was more critical in male rats. Blood lipids tended to increase in female rats. Gonadal dysfunction was observed in both male and female rats with aging. Microangiopathies, such as nephropathy, retinopathy, neuropathy, and osteoporosis, were seen in both genders, and pathological grade and progression were more significant in males. Qualitative and quantitative changes were observed for metabolic disease gender differences in SDT fatty rats. The SDT fatty rat is a useful model for researching gender differences in metabolic disorders and related diseases in diabetes with obesity.
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katsuda
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Miyajima
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Tomohiko
authors.identifier: 0000-0003-3387-6052
authors.initials: T
authors.lastname: Sasase
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kimura
authors.affiliation: Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Bin
authors.identifier: 0000-0003-4170-8737
authors.initials: B
authors.lastname: Tong
authors.affiliation: Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Takahisa
authors.identifier: 0000-0003-2800-4989
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000150:complications / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006949:Hyperlipidemias / Q000150:complications / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008297:Male; D008833:Microcirculation; D009765:Obesity / Q000150:complications*; D010024:Osteoporosis / Q000150:complications / Q000503:physiopathology; D051381:Rats; D055647:Rats, Transgenic; D012720:Severity of Illness Index; D012727:Sex Characteristics; D012737:Sex Factors
chemical_list: D007328:Insulin