title: Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice.
abstract: The purpose of this study is to investigate the anti-inflammatory effect of thalidomide (Thd) on H1N1-induced acute lung injury in mice. BALB/C mice were infected intranasally with influenza A virus (H1N1) and then treated with Thd at a dose of 100 or 200 mg/kg/day for 7 days. Weight loss and survival of mice were monitored for 14 days after virus challenge, and the serum and lung tissues were collected at 4 days for histological and biochemical analysis. The results showed that Thd significantly improved the survival rate, reduced the infiltration of inflammatory cells and cytokine (e.g., IL-6, TNF-α) and chemokine (e.g., RANTES, IP-10) levels, and inhibited activated p-NFκB p65 in infected mice. These findings suggested that Thd may attenuate H1N1-induced pulmonary injury and thus may find use in the treatment of viral diseases.
authors.affiliation: Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhu
authors.forename: Xunlong
authors.initials: X
authors.lastname: Shi
authors.forename: Dianwen
authors.initials: D
authors.lastname: Ju
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Dong
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000378:metabolism; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D055370:Lung Injury / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000378:metabolism; D011897:Random Allocation; D013792:Thalidomide / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D013792:Thalidomide