title: Novel 2-aminobenzamides as potential orally active antithrombotic agents.
abstract: In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.
authors.affiliation: Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Verma
authors.affiliation: Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.
authors.forename: Rajani
authors.initials: R
authors.lastname: Giridhar
authors.affiliation: Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Kanhed
authors.affiliation: Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.
authors.forename: Anshuman
authors.initials: A
authors.lastname: Sinha
authors.affiliation: Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.
authors.forename: Pratik
authors.initials: P
authors.lastname: Modh
authors.affiliation: Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.
authors.forename: Mange R
authors.initials: MR
authors.lastname: Yadav
keywords: 2-aminobenzamide; antiplatelet; antithrombotic agents; ionic liquid; thromboembolic disorders