title: A novel treatment option for MRSA pneumonia: ceftaroline fosamil-yielding new hope in the fight against a persistent infection.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) hospital-acquired pneumonia (HAP) and healthcare-associated pneumonia (HCAP) patients treated with current antibiotic therapies have exhibited poor outcomes, increased hospital length of stay, and higher costs of care. The optimal management of these infections is undetermined; thus, it is critical to look at ways to improve outcomes in these patients. There is insufficient data on clinical efficacy in patients with MRSA HAP or HCAP infection treated with ceftaroline-fosamil. In a recent pilot study, nearly 90% of patients treated with ceftaroline-fosamil survived, despite the difficulties associated with administrating bactericidal antimicrobial therapy for this increasingly resistant pathogen. These data suggest a possible benefit in the use of ceftaroline-fosamil for MRSA pneumonia. Presently, we have identified cases over a two-year period treated with ceftaroline-fosamil, and will conduct a comparative analysis to controls (those treated with vancomycin and/or cefepime, and linezolid) to determine optimal therapeutic agents; these findings will have important implications for control of further spread of infection, recurrence, readmission, and mortality attributable to MRSA HAP and HCAP.
authors.affiliation: Henry Ford Hospital, Infectious Diseases, 2799 West Grand Blvd, CFP 3, Detroit, MI 48202, USA.
authors.forename: Samia
authors.initials: S
authors.lastname: Arshad
authors.forename: Pamela
authors.initials: P
authors.lastname: Hartman
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Zervos
mesh_terms: D002511:Cephalosporins / Q000627:therapeutic use*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy* / Q000401:mortality; D016896:Treatment Outcome; D000097583:Ceftaroline
chemical_list: D002511:Cephalosporins; D000097583:Ceftaroline
keywords: MRSA; antimicrobials; ceftaroline fosamil; pneumonia; vancomycin