title: Historical overview and review of current day treatment in the management of acute variceal haemorrhage.
abstract: Variceal haemorrhage is one of the most devastating consequences of portal hypertension, with a 1-year mortality of 40%. With the passage of time, acute management strategies have developed with improved survival. The major historical treatment landmarks in the management of variceal haemorrhage can be divided into surgical, medical, endoscopic and radiological breakthroughs. We sought to provide a historical overview of the management of variceal haemorrhage and how treatment modalities over time have impacted on clinical outcomes. A PubMed search of the following terms: portal hypertension, variceal haemorrhage, gastric varices, oesophageal varices, transjugular intrahepatic portosystemic shunt was performed. To complement this, Google™ was searched with the aforementioned terms. Other relevant references were identified after review of the reference lists of articles. The review of therapeutic advances was conducted divided into pre-1970s, 1970/80s, 1990s, 2000-2010 and post-2010. Also, a summary and review on the pathophysiology of portal hypertension and clinical outcomes in variceal haemorrhage was performed. Aided by the development of endoscopic therapies, medication and improved radiological interventions; the management of variceal haemorrhage has changed over recent decades with improved survival from an often-terminating event in recent past.
authors.affiliation: Neil Rajoriya, Dhiraj Tripathi, Department of Hepatology, The New Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom.
authors.forename: Neil
authors.initials: N
authors.lastname: Rajoriya
authors.affiliation: Neil Rajoriya, Dhiraj Tripathi, Department of Hepatology, The New Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom.
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Tripathi
mesh_terms: D000818:Animals; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000628:therapy*; D005762:Gastroenterology / Q000266:history; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000628:therapy*; D006470:Hemorrhage / Q000150:complications / Q000628:therapy*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000628:therapy*; D010477:Perfusion; D011170:Portasystemic Shunt, Surgical; D011312:Pressure; D015607:Stents; D016896:Treatment Outcome
keywords: Gastric varices; Oesophageal varices; Portal hypertension; Variceal haemorrhage