title: Images in electroconvulsive therapy: ECS dose-dependently increases cell proliferation in the subgranular region of the rat hippocampus.
abstract: Stress and depression are associated with impaired neuroplasticity in the hippocampus; there is a decrease in neurogenesis, which is hypothesized to decrease the adaptative competence of the organism. Representative light microscopy images are presented which show that 6 once-daily electroconvulsive shocks (ECS), dose-dependently increased new cell formation in the subgranular region of the hippocampus in healthy adult male Wistar rats (10 sections per rat, 3 rats in each of sham ECS, 10 mC, and 40 mC groups). These neuroplasticity changes, demonstrated 1 month after the last ECS, may explain a part of the mechanism of action of electroconvulsive therapy in conditions such as depression.
authors.affiliation: From the *Department of Anatomy, St John's Medical College; Departments of †Neuropathology, ‡Neurophysiology, and §Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: Jangama S M
authors.initials: JS
authors.lastname: Smitha
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Roopa
authors.forename: B K Chandrasekhar
authors.initials: BK
authors.lastname: Sagar
authors.forename: Bindu M
authors.initials: BM
authors.lastname: Kutty
authors.forename: Chittaranjan
authors.initials: C
authors.lastname: Andrade
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004565:Electroconvulsive Therapy; D006624:Hippocampus / Q000166:cytology* / Q000648:ultrastructure*; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar