title: Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.
abstract: Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Johan D
authors.initials: JD
authors.lastname: Oslob
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Johnson
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Haiying
authors.initials: H
authors.lastname: Cai
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Shirley Q
authors.initials: SQ
authors.lastname: Feng
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Lily
authors.initials: L
authors.lastname: Hu
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kosaka
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Julie
authors.initials: J
authors.lastname: Lai
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Mohanram
authors.initials: M
authors.lastname: Sivaraja
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Samnang
authors.initials: S
authors.lastname: Tep
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Hanbiao
authors.initials: H
authors.lastname: Yang
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Cristiana A
authors.initials: CA
authors.lastname: Zaharia
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Evanchik
authors.affiliation: 3-V Biosciences, Inc. , 1050 Hamilton Court, Menlo Park, California 94025, United States.
authors.forename: Robert S
authors.initials: RS
authors.lastname: McDowell
keywords: FASN; HCV; antiviral; in vivo; inhibitor; reversible; structure−activity relationship; target modulation