title: Cespitulones A and B, cytotoxic diterpenoids of a new structure class from the soft coral Cespitularia taeniata.
abstract: Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. z10108042@email.ncku.edu.tw.
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. aska@newbellus.com.tw.
authors.forename: Shih-Sheng
authors.initials: SS
authors.lastname: Wang
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. sionchen@ntu.edu.tw.
authors.forename: Chung-Hsiung
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. kuoyh@nricm.edu.tw.
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. ycshen@ntu.edu.tw.
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy / Q000473:pathology; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C000594481:cespitulone A