title: Palladium-catalyzed direct C2 arylation of N-substituted indoles with 1-aryltriazenes.
abstract: A novel and efficient palladium-catalyzed C2 arylation of N-substituted indoles with 1-aryltriazenes for the synthesis of 2-arylindoles was developed. In the presence of BF3⋅OEt2 and palladium(II) acetate (Pd(OAc)2), N-substituted indoles reacted with 1-aryltriazenes in N,N-dimethylacetamide (DMAC) to afford the corresponding aryl-indole-type products in good to excellent yields.
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000 (P.R. China), Fax: (+86) 561-3090518.
authors.forename: Can
authors.initials: C
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Miao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Pinhua
authors.initials: P
authors.lastname: Li
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D014226:Triazenes / Q000737:chemistry*
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D014226:Triazenes; D010165:Palladium
keywords: arylation; cross-coupling; heterocycles; homogeneous catalysis; palladium