title: Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats.
abstract: Diabetic neuropathy is one of common complications of diabetes mellitus. Hyperglycemia induced oxidative stress involves in the development of diabetic neuropathy, which could be reversed by supplementation of taurine, an endogenous antioxidant. This experiment was conducted to evaluate alterations in the expressions of transcription factors [nuclear factor kappa B (NF-κB), nuclear factor-E2-related factor-2 (Nrf2), and heme oxygenase 1 (HO-1)] and glucose transporters and glucose metabolism in the brain of diabetic rats. In a 2×2 factorially arranged groups, taurine (2%) or water was administered per orally to healthy and streptozotocin (STZ)-induced diabetic rats (n=10 per group) for 8 weeks. Diabetes was associated with weight loss, hyperglycemia, and oxidative stress as reflected by increased serum malondialdehyde (MDA) concentrations. Diabetic rat brains had increased the NF-κB expression and decreased the Nrf2, HO-1, GLUT1,3 expressions as compared to healthy rat brains. Supplemental taurine did not alter body weight and blood glucose concentration, but partially reduced serum MDA concentration in the diabetic rats. Taurine also partially alleviated neuroinflammation as reflected by suppressed the NF-κB expression and enhanced the Nrf2, HO-1, GLUT1,3 expressions in the diabetic rats. In conclusion, taurine reduces the severity of oxidative stress through activating antioxidative defense signaling pathway in diabetic rat brain.
authors.affiliation: Department of Molecular Biology and Genetics, Faculty of Science, Bingol University, Bingol, Turkey.
authors.forename: Can Ali
authors.initials: CA
authors.lastname: Agca
authors.affiliation: Department of Biology, Faculty of Science, Firat University, Elazig, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tuzcu
authors.affiliation: Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.
authors.forename: Armagan
authors.initials: A
authors.lastname: Hayirli
authors.affiliation: Department of Animal Nutrition, Faculty of Veterinary, Ataturk University, Erzurum, Turkey. Electronic address: nsahinkm@yahoo.com.
authors.forename: Kazim
authors.initials: K
authors.lastname: Sahin
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000517:prevention & control*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D015398:Signal Transduction; D013654:Taurine / Q000494:pharmacology*
chemical_list: D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495637:Nfe2l2 protein, rat; D013654:Taurine; D051547:Heme Oxygenase-1
keywords: Diabetic neuropathy; HO-1; NF-κB; Nrf2; Oxidative stress; Taurine