title: Preparation of melt-spun antimicrobially modified LDH/polyolefin nanocomposite fibers.
abstract: Layered double hydroxide (LDH) was synthesized and organically modified with camphorsulfonic acid (CSA) and ciprofloxacin. The thermal stability of CSA was improved remarkably under LDH shielding. A minimal inhibitory concentration of free CSA against tested bacteria was determined in order to define the essential quantity in LDH modification. The modified LDHs were melt-compounded with high density polyethylene and the prepared nanocomposites were further melt-spun using a piston-type spinning device. The melt-spun fibers were tested for their antimicrobial activity against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Enterobacter cloacae, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes. CSA integrated fibers show susceptibility against Gram-positive bacteria and ciprofloxacin integrated fibers showed activity against both Gram-positive and Gram-negative bacteria.
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany; Technische Universität Dresden, Institut für Werkstoffwissenschaft, 01062 Dresden, Germany. Electronic address: kutlu@ipfdd.de.
authors.forename: Burak
authors.initials: B
authors.lastname: Kutlu
authors.affiliation: Technische Universität Dresden, Institut für Med. Mikrobiologie und Hygiene, 01307 Dresden, Germany.
authors.forename: Percy
authors.initials: P
authors.lastname: Schröttner
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Leuteritz
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
authors.forename: Regine
authors.initials: R
authors.lastname: Boldt
authors.affiliation: Technische Universität Dresden, Institut für Med. Mikrobiologie und Hygiene, 01307 Dresden, Germany.
authors.forename: Enno
authors.initials: E
authors.lastname: Jacobs
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany; Technische Universität Dresden, Institut für Werkstoffwissenschaft, 01062 Dresden, Germany.
authors.forename: Gert
authors.initials: G
authors.lastname: Heinrich
mesh_terms: D000535:Aluminum / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006878:Hydroxides / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry*; D020959:Polyethylene / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D006878:Hydroxides; D002939:Ciprofloxacin; D020959:Polyethylene; C031356:hydroxide ion; D000535:Aluminum; D008274:Magnesium
keywords: antimicrobiality; layered double hydroxide; melt-spinning; thermostability