title: BDCA3(+)CLEC9A(+) human dendritic cell function and development.
abstract: Dendritic cells (DC) are the most potent antigen presenting cells (APC). They comprise a family of different subsets and play an essential role in the induction and regulation of immune responses. Recently, gene expression profiling identified BDCA3(+)CLEC9A(+) DC as a separate human DC subset. This subset was identified in blood, where they represent the smallest population of human DC, as well as in lymphoid and peripheral tissues. This review summarizes the phenotypic, functional and developmental characteristics of BDCA3(+)CLEC9A(+) DC in relation to their mouse equivalents CD8α(+) DC and CD103(+) DC and other human DC subsets. Apart from being potent antigen presenting cells, their specialized functional capacities compared to other human DC subsets, indicate that these BDCA3(+)CLEC9A(+) DC are of major importance in the induction of anti-viral and anti-tumor immunity. Further characterization of their functional properties, developmental pathways and underlying molecular mechanisms may identify target molecules to fully exploit the immune modulatory function of BDCA3(+)CLEC9A(+) DC and potential use of these cells in immunotherapy.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
authors.forename: Evelyn
authors.initials: E
authors.lastname: van der Aa
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
authors.forename: Nadine
authors.initials: N
authors.lastname: van Montfoort
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. Electronic address: a.woltman@erasmusmc.nl.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Woltman
mesh_terms: D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D045142:Cross-Priming / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000276:immunology / Q000378:metabolism; D037181:Lectins, C-Type / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D011975:Receptors, Mitogen / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D018180:Thrombomodulin; D000095022:Interferon Lambda
chemical_list: D000954:Antigens, Surface; D016207:Cytokines; D007372:Interferons; D007378:Interleukins; D037181:Lectins, C-Type; D011975:Receptors, Mitogen; D018180:Thrombomodulin; C530206:CLEC9a protein, human; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C546931:THBD protein, human
keywords: BDCA3; Cross-presentation; Dendritic cell subset; Human; IFNλ; Immune regulation