title: Induced antiviral innate immunity in Drosophila.
abstract: Immunity to viral infections in the model organism Drosophila melanogaster involves both RNA interference and additional induced responses. The latter include not only cellular mechanisms such as programmed cell death and autophagy, but also the induction of a large set of genes, some of which contribute to the control of viral replication and resistance to infection. This induced response to infection is complex and involves both virus-specific and cell-type specific mechanisms. We review here recent developments, from the sensing of viral infection to the induction of signaling pathways and production of antiviral effector molecules. Our current understanding, although still partial, validates the Drosophila model of antiviral induced immunity for insect pests and disease vectors, as well as for mammals.
authors.affiliation: CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue Descartes, F-67084 Strasbourg, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lamiable
authors.affiliation: CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue Descartes, F-67084 Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, 28 rue Goethe, F-67083 Strasbourg, France. Electronic address: JL.Imler@unistra.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Imler
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000276:immunology / Q000821:virology*; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D012328:RNA Viruses / Q000276:immunology*; D015398:Signal Transduction