title: Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes.
abstract: Permeability plays an important role to achieve the desired therapeutic outcomes. Present study was designed to investigate the permeability of ciprofloxacin from ultrathin polyvinyl alcohol nanofiber through different biological membranes. Results of the permeability studies indicated that nanofibers exhibit higher drug permeability than plane drug. Intestinal tissue shows maximum permeability followed by eye, trachea, sublingual, rectal, and skin. Permeability studies also inferred a steady-state release of drug of the nanofiber, whereas a high degree of fluctuations was observed in plane drug. Nanofiber being 2D nanoscale material provides numerous advantages to be used as an encapsulated carrier system to improve the therapeutic effectiveness.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Vedant
authors.initials: V
authors.lastname: Modgill
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Goyal
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002463:Cell Membrane Permeability; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D015194:Diffusion Chambers, Culture; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D005123:Eye / Q000378:metabolism; D006041:Goats; D007413:Intestinal Mucosa / Q000378:metabolism; D009061:Mouth Mucosa / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D009928:Organ Specificity; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012007:Rectum / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D014132:Trachea / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002939:Ciprofloxacin; D011142:Polyvinyl Alcohol
keywords: ciprofloxacin; drug permeability; nanofibers; polyvinyl alcohol