title: Synthesis and antimicrobial activities of 5-Arylidene-thiazolidine-2,4-dione derivatives.
abstract: Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 µg/mL.
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Ivanildo Mangueira
authors.initials: IM
authors.lastname: da Silva
authors.affiliation: Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: da Silva Filho
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Priscila Brandão Gomes da Silva
authors.initials: PB
authors.lastname: Santiago
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Micalyne Soares
authors.initials: MS
authors.lastname: do Egito
authors.affiliation: Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Carlos André
authors.initials: CA
authors.lastname: de Souza
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Frederico Leite
authors.initials: FL
authors.lastname: Gouveia
authors.affiliation: Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Rafael Matos
authors.initials: RM
authors.lastname: Ximenes
authors.affiliation: Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Kêsia Xisto da Fonseca Ribeiro
authors.initials: KX
authors.lastname: de Sena
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Antonio Rodolfo
authors.initials: AR
authors.lastname: de Faria
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Dalci José
authors.initials: DJ
authors.lastname: Brondani
authors.affiliation: Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil ; Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Julianna Ferreira Cavalcanti
authors.initials: JF
authors.lastname: de Albuquerque
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000138:chemical synthesis*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D053778:Thiazolidines / Q000008:administration & dosage* / Q000138:chemical synthesis*
chemical_list: D000890:Anti-Infective Agents; D053778:Thiazolidines