title: Relationship between adiposity, adipokines, inflammatory markers and lipid profile in hemodialysis patients.
abstract: OBJECTIVE
  Our aim is to study the correlations of leptin and adiponectin with inflammation markers, body composition and lipid profile in end stage renal disease (ESRD) patients.
  
  
  METHODS
  Phase angle values and fat mass as calculated using BIA, Malnutrition-Inflammation Score (MIS), leptin, adiponectin, IL-6, IL-8 triglycerides, cholesterol and other common serum markers' concentrations were analyzed using simple and multiple linear regression models in 47 hemodialysis patients.
  
  
  RESULTS
  In contrast to leptin, adiponectin is inversely correlated to BMI and fat mass in hemodialysis patients. Triglycerides were the only parameter that retained its statistical correlation significance with adiponectin in the multiple regression model.
  
  
  CONCLUSIONS
  Fat mass is of important consideration when calculating adipokines levels and their possible correlations with other variables. The inverse correlation of adiponectin with triglycerides levels should be further delineated due to the important role of vascular diseases in total mortality and morbidity of ESRD patients.
authors.affiliation: School of Medicine, University of Crete, Crete, Greece. gkouskou@imbb.forth.gr.
authors.forename: A
authors.initials: A
authors.lastname: Markaki
authors.forename: K
authors.initials: K
authors.lastname: Gkouskou
authors.forename: K
authors.initials: K
authors.lastname: Stylianou
authors.forename: E
authors.initials: E
authors.lastname: Dermitzaki
authors.forename: K
authors.initials: K
authors.lastname: Perakis
authors.forename: A
authors.initials: A
authors.lastname: Margioris
authors.forename: E
authors.initials: E
authors.lastname: Daphnis
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity; D001823:Body Composition; D001827:Body Height; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood*
chemical_list: D052242:Adiponectin; C508606:CXCL8 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D020738:Leptin; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol