title: A prospective randomized controlled trial comparing N-butyl-2 cyanoacrylate (Histoacryl), octyl cyanoacrylate (Dermabond), and subcuticular suture for closure of surgical incisions.
abstract: BACKGROUND
  The use of tissue adhesives for the closure of surgical incisions is increasing. Few studies directly compare tissue adhesives to one another or focus on the difference in wound closure time between tissue adhesives. We compared the use of N-butyl-2 cyanoacrylate (Histoacryl), octyl cyanoacrylate (Dermabond), or subcuticular suture in incisions resulting from reduction mammoplasty, mastopexy, panniculectomy, and abdominoplasty.
  
  
  METHODS
  A 2-armed prospective randomized controlled trial was performed. Part 1 compared closure of surgical incisions with N-butyl-2 cyanoacrylate and octyl cyanoacrylate. Part 2 compared the closure of surgical incisions with N-butyl-2 cyanoacrylate and subcuticular suture. End points were closure time, scar width, and satisfaction ratings.
  
  
  RESULTS
  Both study arms revealed significantly faster closer times with N-butyl-2 cyanoacrylate [9/10 in part 1 (P = 0.022) and 10/10 in part 2 (P = 0.002)]. Scar width difference did not reach statistical significance, and there was no difference in surgeon, independent reviewer, or patient satisfaction among the materials.
  
  
  CONCLUSIONS
  Our results demonstrate a decreased time required for wound closure using N-butyl-2 cyanoacrylate compared to both suture and octyl cyanoacrylate regardless of incision type with no significant difference in scar width or satisfaction ratings.
authors.affiliation: From the *Mayo Clinic Florida Department of General Surgery, and †Division of Plastic Surgery, Mayo Clinic Florida, Jacksonville, FL.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Koonce
authors.forename: Dustin L
authors.initials: DL
authors.lastname: Eck
authors.forename: Kyle K
authors.initials: KK
authors.lastname: Shaddix
authors.forename: Galen
authors.initials: G
authors.lastname: Perdikis
mesh_terms: D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000209:etiology; D003487:Cyanoacrylates; D004659:Enbucrilate; D005260:Female; D006801:Humans; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D011446:Prospective Studies; D013536:Suture Techniques; D013997:Time Factors; D014014:Tissue Adhesives; D014945:Wound Healing
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate; D004659:Enbucrilate