title: Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).
abstract: Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Chris P
authors.initials: CP
authors.lastname: Carron
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: John I
authors.initials: JI
authors.lastname: Trujillo
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Kirk L
authors.initials: KL
authors.lastname: Olson
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Hamper
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Tom
authors.initials: T
authors.lastname: Dice
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Neal
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Pelc
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Day
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Rohrer
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: James R
authors.initials: JR
authors.lastname: Kiefer
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Moon
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Schweitzer
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Tanisha D
authors.initials: TD
authors.lastname: Blake
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Steve R
authors.initials: SR
authors.lastname: Turner
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Rhonda
authors.initials: R
authors.lastname: Woerndle
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Case
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Christine P
authors.initials: CP
authors.lastname: Bono
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Vickie M
authors.initials: VM
authors.lastname: Dilworth
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Christie L
authors.initials: CL
authors.lastname: Funckes-Shippy
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Becky L
authors.initials: BL
authors.lastname: Hood
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Gina M
authors.initials: GM
authors.lastname: Jerome
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Kornmeier
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Radabaugh
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Melanie L
authors.initials: ML
authors.lastname: Williams
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Davies
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Craig D
authors.initials: CD
authors.lastname: Wegner
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Welsch
authors.affiliation: Department of Research, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, Florida 33140.
authors.forename: William M
authors.initials: WM
authors.lastname: Abraham
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Chad J
authors.initials: CJ
authors.lastname: Warren
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Dowty
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Fengmei
authors.initials: F
authors.lastname: Hua
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Anup
authors.initials: A
authors.lastname: Zutshi
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Jerry Z
authors.initials: JZ
authors.lastname: Yang
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.
authors.forename: Atli
authors.initials: A
authors.lastname: Thorarensen
keywords: Hematopoietic prostaglandin D synthase (HPGDS); PGD2; PGH2; airway allergy; inflammatory processes, cyclooxygenase (COX)