title: Expression of insulin-like growth factors in the placenta in preeclampsia.
abstract: Comparative morphological study of the placentas in women with preeclampsia and small-for-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemical methods. Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia, e_dubova@oparina4.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Dubova
authors.forename: K A
authors.initials: KA
authors.lastname: Pavlov
authors.forename: V M
authors.initials: VM
authors.lastname: Lyapin
authors.forename: G V
authors.initials: GV
authors.lastname: Kulikova
authors.forename: A I
authors.initials: AI
authors.lastname: Shchyogolev
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005333:Fetus; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics* / Q000378:metabolism; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II