title: Photodynamic therapy using a new formulation of 5-aminolevulinic acid for wrinkles in Asian skin: A randomized controlled split face study.
abstract: BACKGROUND
  Photodynamic therapy (PDT) with intense pulsed light (IPL) was proven effective for photorejuvenation. Recently, a new formulation of 0.5% 5-aminolevulinic acid (ALA) liposomal spray has been available. We designed a randomized split face study to evaluate usefulness and safety of IPL-PDT using a liposomal spray for periorbital wrinkles in Asians.
  
  
  METHODS
  Patients received three treatments every 3 weeks. The half of the face was treated with IPL-PDT and the other half with long pulsed Nd:YAG laser (LPNY). Skin fluorescence was measured using a spectrophotometer for the guidance of PDT treatment. Wrinkle score was marked by two-blinded independent dermatologists.
  
  
  RESULTS
  One patient dropped out due to 3-d lasting erythema on PDT side. The difference of mean reduction in lower and lateral periorbital wrinkle score on PDT side between the first and the last visit was statistically significant (p = 0.008 and p = 0.001, respectively). Lateral periorbital wrinkles treated with PDT showed better results than LPNY-treated sides. Twenty-five percent of patients reported good to excellent outcomes.
  
  
  CONCLUSIONS
  This study demonstrated that PDT with a liposomal spray provided modest wrinkle reduction without serious adverse effect and it might be a promising treatment modality for wrinkle treatment in Asians.
authors.affiliation: Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.
authors.forename: Hyun Tae
authors.initials: HT
authors.lastname: Shin
authors.forename: Jun Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Joonho
authors.initials: J
authors.lastname: Shim
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Dong Youn
authors.initials: DY
authors.lastname: Lee
authors.forename: Joo Heung
authors.initials: JH
authors.lastname: Lee
authors.forename: Jun Mo
authors.initials: JM
authors.lastname: Yang
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D044466:Asian People; D004890:Erythema / Q000209:etiology; D005145:Face; D005260:Female; D006801:Humans; D062325:Intense Pulsed Light Therapy / Q000379:methods*; D053844:Lasers, Solid-State / Q000627:therapeutic use; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D008081:Liposomes; D000622:Aminolevulinic Acid
keywords: 5-aminolevulinic acid 0.5%; liposomal spray; periorbital wrinkles in Asian skin; photodynamic therapy