title: Efficacy and safety of remifentanil and sulfentanyl in painless gastroscopic examination: a prospective study.
abstract: We aim to assess efficacy and safety of remifentanil or sulfentanyl combined with propofol during painless gastroscopic examination in patients. In this study, 270 patients were randomly divided into 3 groups: propofol was given only in group P; propofol and remifentanil in group PR; propofol and sulfentanyl in group PS during the gastroscopic examination. Efficiency of group P was significantly higher than that of group PR and PS (P<0.01) [corrected]. Efficiency of group PR was lower than that of group PS (P<0.05). Incidence of chest wall rigidity and oxygen desaturation in group PR were higher than group P and PS (P<0.05), whereas there was no difference between groups P and PS (P>0.05). Propofol combined with remifentanil could provide satisfying anesthesia and more respiratory depression, whereas sulfentanyl at equivalent dose combined with propofol could also provide with satisfying anesthesia and less respiratory depression. Combined sufentanyl with propofol would be an effective anesthesia technique in the daytime procedure.
authors.affiliation: Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, China.
authors.forename: Yin-Jie
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Su
authors.initials: S
authors.lastname: Liu
authors.forename: Qing-Xiang
authors.initials: QX
authors.lastname: Mao
authors.forename: Heng-Jiang
authors.initials: HJ
authors.lastname: Ge
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Bing-Qiang
authors.initials: BQ
authors.lastname: Huang
authors.forename: Wu-Chao
authors.initials: WC
authors.lastname: Wang
authors.forename: Jun-Ran
authors.initials: JR
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods*; D010880:Piperidines / Q000008:administration & dosage*; D011446:Prospective Studies; D000077208:Remifentanil; D017409:Sufentanil / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D017409:Sufentanil; D000077208:Remifentanil