title: Mean platelet volume in schizophrenia unaltered after 1year of clozapine exposure.
abstract: This study investigated the MPV of patients with major psychoses before and after 1year of clozapine exposure. Data were obtained from chart reviews of patients who were initiated on clozapine at the Centre of Addiction and Mental Health (CAMH) in Toronto. 100 patients were eligible for this study; 65 remained on clozapine after 1year. Prior to clozapine initiation, MPV was 10.79±0.91fL and there was no difference in MPV after 1year of clozapine exposure (p=0.777). We found high MPV in patients with schizophrenia and related psychoses, which was unaltered after 1year of clozapine treatment.
authors.affiliation: Department of General Psychiatry 1, Institute of Mental Health, Singapore, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore; Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address: jimmy_lee@imh.com.sg.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Lee
authors.affiliation: Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
authors.forename: Valerie
authors.initials: V
authors.lastname: Powell
authors.affiliation: Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
authors.forename: Gary
authors.initials: G
authors.lastname: Remington
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D009864:Ontario; D011618:Psychotic Disorders / Q000188:drug therapy / Q000503:physiopathology; D012042:Registries; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
keywords: Acute myocardial infarction; Antipsychotics; Cardiovascular; Inflammation