title: Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: twelve-month findings.
abstract: OBJECTIVE
  To report 1-year outcomes of the Prospective Retinal and Optic Nerve Vitrectomy Evaluation study.
  
  
  METHODS
  Prospective, controlled, observational study.
  
  
  METHODS
  Eighty eyes of 40 participants undergoing pars plana vitrectomy for epiretinal membrane (ERM), macular hole (MH), or vitreous opacities.
  
  
  METHODS
  Enrolled participants underwent baseline evaluation of the study (surgical) and fellow (control) eyes by a masked fellowship-trained glaucoma specialist; evaluation included intraocular pressure (IOP; Goldmann applanation and Tono-Pen), central corneal thickness, gonioscopy, and cup-to-disc ratio measurement. Baseline testing included bilateral color fundus and optic disc photography, fundus autofluorescence, automated perimetry, and optical coherence tomography (OCT) of the macula and optic nerve. Evaluations were repeated at 3 months and 1 year after surgery.
  
  
  METHODS
  The primary outcome measure was changes in peripapillary retinal nerve fiber layer (pRNFL) thickness. Secondary outcomes included changes in macular thickness and IOP.
  
  
  RESULTS
  Thirty-eight of 40 patients completed 1 year of follow-up. Mean visual acuity (VA) improved in study eyes from baseline (P = 0.003) but remained worse than fellow eyes (P<0.001). Study eyes had thinner inferior pRNFL thickness (114±16.8 μm) compared with fellow eyes (123±14.7 μm; P = 0.004). Mean IOP difference between study eyes and fellow eyes increased from baseline to 1 year. At 1 year, MH study eyes had higher mean IOP (16.0±3.7 mmHg) compared with fellow eyes (14.8±3.4 mmHg; P = 0.08). Mean IOP for pseudophakic study eyes increased from 14.5±3.2 mmHg at baseline to 16.0±2.8 mmHg at 1 year (P = 0.04). Central subfield thickness (CST) and cube volume decreased in study eyes at 1 year but remained greater than that of fellow eyes (P<0.05). Reduction in CST from baseline correlated with degree of VA improvement (P<0.05). Mean deviation (MD) improved in ERM study eyes at 1 year when compared with baseline (-2.2 vs. -4.0; P = 0.02) but remained worse than fellow eyes (-1.2; P = 0.002).
  
  
  CONCLUSIONS
  One year after vitrectomy, VA, CST, and MD improved in study eyes but not to the level of fellow eyes. Inferior pRNFL thickness decreased in study eyes. Reduction in CST from baseline correlated with degree of VA improvement. Pseudophakic study eyes demonstrated increased IOP when compared with baseline.
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee; Southern California Desert Retina Consultants, Palm Desert, California.
authors.forename: Maziar
authors.initials: M
authors.lastname: Lalezary
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Rohan J
authors.initials: RJ
authors.lastname: Shah
authors.affiliation: Associated Retinal Consultants of Phoenix, Phoenix, Arizona.
authors.forename: Rahul K
authors.initials: RK
authors.lastname: Reddy
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kammer
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Rachel W
authors.initials: RW
authors.lastname: Kuchtey
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Joos
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Cherney
authors.affiliation: Tennessee Retina PC, Nashville, Tennessee.
authors.forename: Franco M
authors.initials: FM
authors.lastname: Recchia
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address: skim30@gmail.com.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019773:Epiretinal Membrane / Q000601:surgery; D005128:Eye Diseases / Q000601:surgery*; D005901:Glaucoma / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D012167:Retinal Perforations / Q000601:surgery; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects / Q000379:methods*