title: Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation.
abstract: Pleomorphic xanthoastrocytoma (PXA) is classified by the World Health Organization as a grade II astrocytic tumor with relatively favorable prognosis among gliomas. A valine-to-glutamic acid substitution at position 600 of the serine/threonine-protein kinase BRAF (BRAF V600E) mutation, which is commonly found in PXA, has recently been detected in approximately 50% of all epithelioid glioblastoma (GBM) cases. We herein report a case of epithelioid GBM developing at the site of a left temporal PXA 13 years after the treatment of the primary tumor. The BRAF V600E mutation was detected in both tumors. These findings suggest that epithelioid GBM may arise from a PXA with a BRAF V600E mutation.
authors.affiliation: Division of Neuroscience, Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakada
authors.forename: Sumihito
authors.initials: S
authors.lastname: Nobusawa
authors.forename: Satoshi O
authors.initials: SO
authors.lastname: Suzuki
authors.forename: Hemragul
authors.initials: H
authors.lastname: Sabit
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Miyashita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D001254:Astrocytoma / Q000235:genetics* / Q000473:pathology*; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology*; D018698:Glutamic Acid; D006801:Humans; D008279:Magnetic Resonance Imaging; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000473:pathology*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D013997:Time Factors; D014633:Valine
chemical_list: D018698:Glutamic Acid; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D014633:Valine