title: Alteration of serum bilirubin level in schizophrenia.
abstract: Abstract Objective. Alteration of serum bilirubin level in acute episodes of psychosis in patients with schizophrenia has been reported but the pattern of this alteration is controversial. Methods. Patients diagnosed as schizophrenia (162, group S) or bipolar disorder (155, group B) entered the study. The control group consisted of 95 patients admitted to cardiac care unit who had no personal or family history of major psychiatric disorders. Pre- and post-admission levels of bilirubin were measured and compared within and between the groups. Patients were examined to exclude all other causes of hyperbilirubinemia. Group S and B participants were also evaluated using positive and negative syndrome subscale (PANSS) both at admission and discharge. Results. The mean admission bilirubin levels of all the groups were in the normal range (significantly higher in group S than groups B and C) and were affected by the score of general psychopathology subscale rather than the scores of positive symptoms subscale. Conclusions. Although bilirubin decreased in all three groups at discharge, the rate of decrease was significantly higher in group S. The reason for this is not clear and needs further study.
authors.affiliation: Behavioral Science Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Semnani
authors.forename: Farzad
authors.initials: F
authors.lastname: Nazemi
authors.forename: Aileen
authors.initials: A
authors.lastname: Azariyam
authors.forename: Mohammad Javad Ehsani
authors.initials: MJ
authors.lastname: Ardakani
keywords: Gilbert's disease; Psychotic disorders; bilirubin; bipolar disorder; schizophrenia