title: Contemporary treatment options for relapsing-remitting multiple sclerosis.
abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, encompassing both neuroinflammatory as well as prominent neurodegenerative aspects. A significant proportion of MS patients will develop neurological disability over time and up until recently licensed drugs could not satisfactorily halt this process. However, in the last years MS treatment has raised a stage of rapid progress. Several new drugs with significantly improved efficacy have entered the therapeutic field and several others are currently undergoing phase III clinical trials. In this review, we will summarize efficacy data as well as safety and tolerability issues of currently licensed drugs for relapsing-remitting MS and will give a short update on new drugs currently undergoing late-stage clinical trials.
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Salhofer-Polanyi
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria. Fritz.Leutmezer@meduniwien.ac.at.
authors.forename: F
authors.initials: F
authors.lastname: Leutmezer
mesh_terms: D000074323:Alemtuzumab; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000069462:Dimethyl Fumarate; D005650:Fumarates / Q000627:therapeutic use; D000068717:Glatiramer Acetate; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008942:Mitoxantrone / Q000627:therapeutic use; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D005650:Fumarates; D010455:Peptides; D000074323:Alemtuzumab; D000068717:Glatiramer Acetate; D016899:Interferon-beta; D008942:Mitoxantrone; D000069462:Dimethyl Fumarate
keywords: Alemtuzumab; Dimethyl fumarate; Fingolimod; Multiple sclerosis; Relapsing-remitting multiple sclerosis; Teriflunomide