title: Research progress in signalling pathway in diabetic nephropathy.
abstract: Diabetic nephropathy, a lethal diabetic complication, is a leading cause of end-stage renal disease, which is pathologically characterized by thickened tubular basal and glomerular membranes, accumulated extracellular matrix, and progressive mesangial hypertrophy. Growing evidence indicates that diabetic nephropathy is induced by multiple conditions, such as glucose metabolism disorder, oxidative stress, numerous inflammatory factors and cytokines, and haemodynamic changes that lead to the occurrence and development of diabetic nephropathy based on genetic susceptibility. A variety of abnormalities in the signalling pathway may interact to produce these pathologic processes. Research has aimed to highlight the signalling pathway mechanisms that lead to diabetic nephropathy so that preventative strategies and effective therapies might be developed. In this review, important pathways that appear to be involved in driving these processes are discussed.
authors.affiliation: Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, Anhui Province, China; Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, Anhui Province, China.
authors.forename: Wei-Jian
authors.initials: WJ
authors.lastname: Ni
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Tang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
mesh_terms: D003928:Diabetic Nephropathies / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D006801:Humans; D007249:Inflammation; D018384:Oxidative Stress; D015398:Signal Transduction
keywords: diabetic nephropathy; glomerular mesangial cell; podocyte; renal fibrosis; signalling pathway