title: Synthesis, characterization, biological and catalytic applications of transition metal complexes derived from Schiff base.
abstract: A novel series of Cu(II), Ni(II), Zn(II), Co(II), and Cd(II) complexes have been synthesized from the Schiff base. Structural features were determined by analytical and spectral techniques like IR, (1)H NMR, UV-vis, elemental analysis, molar electric conductibility, magnetic susceptibility and thermal studies. The complexes are found to be soluble in dimethylformamide and dimethylsulfoxide. Molar conductance values in dimethylformamide indicate the non-electrolytic nature of the complexes. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied. There is significant binding of DNA in lanes 2, 3, and 5. Lanes 4 and 6 are showing more florescence when compared to the control indicating that these molecules are strongly bound to the DNA by inserting themselves between the two stacked base pairs and exhibiting their original property of fluorescence. Angiogenesis study has revealed that the compounds B-2, B-4 and B-5 have potent antitumor efficacy and activation of antiangiogenesis could be one of the possible underlying mechanisms of tumor inhibition.
authors.affiliation: Department of Chemistry, Yuvaraj's College (Autonomous), University of Mysore, Mysore 570 005, Karnataka, India; Department of Chemistry, D.Banumaiah's P U Science College, Mysore 570 024, Karnataka, India.
authors.forename: A
authors.initials: A
authors.lastname: Bushra Begum
authors.affiliation: Department of Studies in Biotechnology, JSS College of Arts, Commerce and Science, Mysore, India.
authors.forename: N D
authors.initials: ND
authors.lastname: Rekha
authors.affiliation: Department of Chemistry, University of Mysore, Mysore, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Vasantha Kumar
authors.affiliation: Department of Chemistry, Yuvaraj's College (Autonomous), University of Mysore, Mysore 570 005, Karnataka, India.
authors.forename: V
authors.initials: V
authors.lastname: Lakshmi Ranganatha
authors.affiliation: Department of Chemistry, Yuvaraj's College (Autonomous), University of Mysore, Mysore 570 005, Karnataka, India. Electronic address: shaukathara@yahoo.co.in.
authors.forename: Shaukath Ara
authors.initials: SA
authors.lastname: Khanum
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005453:Fluorescence; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry; D013329:Structure-Activity Relationship; D028561:Transition Elements / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012545:Schiff Bases; D028561:Transition Elements; D004247:DNA; C427203:calf thymus DNA
keywords: Angiogenesis; Binding/cleavage of DNA; Schiff base ligand