title: Raised serum proinflammatory cytokines in Alzheimer's disease with depression.
abstract: The purpose of the present study was to identify the changes in the levels of proinflammatory cytokines like IL-1β, IL-6 and TNF-α in peripheral circulation in Alzheimer's disease (AD) subjects and to correlate these with associated depression and cognitive deficit. Fifty five AD subjects and thirty seven age and sex matched controls were included in the study. The AD patients were grouped as AD with depression (n= 31) and AD without depression (n= 24). The serum levels of IL-1β, IL-6 and TNF-α were determined by immunoassay by commercially available kits. The serum levels of IL-6 and TNF-α were elevated in AD patients with depression compared to control (p<0.001) or AD without depression (p<0.001). The serum level of IL-1β was higher in AD patients with or without depression as compared to controls. Furthermore, a strong inverse correlation was observed between the MMSE scores and serum levels of IL-6 or TNF-α in AD subjects with depression. The study highlights the important role of peripheral IL-6 and TNF-α in AD associated depression and cognitive deficits.
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Vineet Kumar
authors.initials: VK
authors.lastname: Khemka
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Ganguly
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Debajit
authors.initials: D
authors.lastname: Bagchi
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Arindam
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Aritri
authors.initials: A
authors.lastname: Bir
authors.affiliation: Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
authors.forename: Atanu
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Community Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Sita
authors.initials: S
authors.lastname: Chattopadhyay
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Sasanka
authors.initials: S
authors.lastname: Chakrabarti
keywords: Alzheimer’s disease; Cognitive deficit; Depression; IL-1β; IL-6; TNF-α