title: Quantitative correlation of aflatoxin biomarker with dietary intake of aflatoxin in Tanzanian children.
abstract: The association between aflatoxin intake from maize-based weaning food and aflatoxin albumin adducts (AF-alb) was investigated in 148 Tanzanian children aged between 12 and 22 months, at 2 visits 6 months apart. At the first visit (storage season) there was a significant correlation at the individual level between AF-alb (geometric mean 43.2 pg/mg albumin) and aflatoxin intake (geometric mean 81.7 ng/kg b.w./d) through maize-based weaning food (r = 0.51, p < 0.01). Overall, this correlation was r = 0.43 (p < 0.01). The AF-alb level in weaning-age children in Tanzania closely reflects aflatoxin intake from maize in weaning food. Exposure levels suggest children may be at risk from aflatoxin associated health effects.
authors.affiliation: School of Medicine, University of Leeds , Leeds , UK .
authors.forename: Michael N
authors.initials: MN
authors.lastname: Routledge
authors.forename: Martin E
authors.initials: ME
authors.lastname: Kimanya
authors.forename: Candida P
authors.initials: CP
authors.lastname: Shirima
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Wild
authors.forename: Yun Yun
authors.initials: YY
authors.lastname: Gong
mesh_terms: D000348:Aflatoxins / Q000008:administration & dosage* / Q000097:blood; D000418:Albumins; D015415:Biomarkers / Q000097:blood*; D004435:Eating; D005260:Female; D005506:Food Contamination / Q000032:analysis* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D013636:Tanzania; D014886:Weaning; D003313:Zea mays
chemical_list: D000348:Aflatoxins; D000418:Albumins; D015415:Biomarkers; C098408:aflatoxin-albumin adduct
keywords: Aflatoxin albumin adduct; aflatoxins; biomarker; dietary intake; early life exposure