title: Optimization therapy for the treatment of chronic hepatitis B.
abstract: Chronic hepatitis B (CHB) is currently medically managed with either interferon-alpha or one of the five nucleos(t)ide analogs. However, there are still a large number of CHB patients whose response to the above therapies remains less than satisfactory, and their incomplete or non-response to antiviral therapies has plagued clinicians worldwide. In recent years, a newly proposed optimization therapy has provided us with a new approach to solve this problem. The key points in this optimization therapy are to initiate antiviral therapy with an appropriate agent at the correct time point, and to adjust treatments in patients with poor early responses by adding a second agent or switching to another more potent agent. In this review, we summarize recent developments in optimization therapy for the treatment of CHB, and provide an outlook for future research in this field.
authors.affiliation: En-Qiang Chen, Hong Tang, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: En-Qiang
authors.initials: EQ
authors.lastname: Chen
authors.affiliation: En-Qiang Chen, Hong Tang, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005355:Fibrosis; D005838:Genotype; D006514:Hepatitis B Surface Antigens / Q000737:chemistry; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors; D007372:Interferons / Q000378:metabolism; D019259:Lamivudine / Q000627:therapeutic use; D057285:Precision Medicine / Q000379:methods; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D007155:Immunologic Factors; D019259:Lamivudine; D007372:Interferons
keywords: Chronic hepatitis B; Interferon; Nucleos(t)ide analog; Optimization therapy; Suboptimal response