title: Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke.
abstract: Metals present in tobacco smoke have the ability to cause a pro-oxidant/antioxidant imbalance through the direct generation of free radicals in accordance with the Fenton or Haber-Weiss reaction and redox properties. Metals can also interact with antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) and small molecular antioxidants (glutathione) through binding to SH groups or by replacement of metals ions in the catalytic center of enzymes. Excessive free radicals production can induce an inflammatory response. The aim of this study was to review the information on the induction of inflammation by metals present in tobacco smoke such as lead (Pb), cadmium (Cd), arsenic (As), aluminum (Al), nickel (Ni) and mercury (Hg). In cellular immune response, it was demonstrated that radicals induced by metals can disrupt the transcription signaling pathway mediated by the mitogen-activated protein kinase (induced by Pb), NLRP3-ASC-caspase 1 (induced by Ni), tyrosine kinase Src (induced by As) and the nuclear factor κB (induced by Pb, Ni, Hg). The result of this is a gene transcription for early inflammatory cytokines, such as Interleukine 1β, Interleukine 6, and Tumor necrosis factor α). These cytokines can cause leukocytes recruitment and secretions of other pro-inflammatory cytokines and chemokines, which intensifies the inflammatory response. Some metals, such as cadmium (Cd), can activate an inflammatory response through tissue damage induction mediated by free radicals, which also results in leukocytes recruitment and cytokines secretions. Inflammation generated by metals can be reduced by metallothionein, which has the ability to scavenge free radicals and bind toxic metals through the release of Zn and oxidation of SH groups.
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Milnerowicz
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland. Electronic address: milena.topola@wp.pl.
authors.forename: Milena
authors.initials: M
authors.lastname: Ściskalska
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Dul
mesh_terms: D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000633:toxicity*; D008670:Metals / Q000633:toxicity*; D008954:Models, Biological; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D005609:Free Radicals; D018836:Inflammation Mediators; D008670:Metals; D014028:Tobacco Smoke Pollution
keywords: Antioxidant enzymes; Inflammation; Metals; Oxidative stress; Tobacco smoke