title: Risk factors for long-term outcome of drug-eluting stenting in adults with early-onset coronary artery disease.
abstract: OBJECTIVE
  We lack data on the long-term outcome of drug-eluting stenting in patients with early-onset coronary artery disease (CAD). Here, we investigated the association of traditional risk factors and major adverse cardiovascular events (MACEs) after drug-eluting stenting in patients with CAD who were < 50 years old.
  
  
  METHODS
  We enrolled 437 consecutive CAD patients < 50 years old who underwent drug-eluting stenting and 132 subjects who were age- and sex-matched and angiographically shown to be disease free as controls. MACEs were analyzed in CAD patients for a median of 24 months [interquartile range 14-34 months].
  
  
  RESULTS
  Male patients accounted for 90.4% of cases. As compared with controls, patients with early-onset CAD had higher body mass index and rates of smoking, family history of CAD, and diabetes and hypercholesterolemia. During the hospital stay, 1 patient died, and the incidence of MACEs was 1.1%. At the end of follow-up, the overall death rate was 0.7%. MACEs were observed in 54 patients (12.4%). On Cox proportional hazard analyses, positive family history and diabetes were independent risk factors of MACEs (HR 2.61, 95% confidence interval 1.29-4.00, p = 0.002; and HR 2.48, 95% confidence interval 0.86-3.14, p = 0.004, respectively).
  
  
  CONCLUSIONS
  Drug-eluting stenting is a reliable treatment for patients with early-onset CAD. Positive family history of CAD and diabetes are independent risk factors of adverse cardiovascular events in this subgroup of patients after drug-eluting stent implantation.
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Guipeng
authors.initials: G
authors.lastname: An
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Du
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Xiao
authors.initials: X
authors.lastname: Meng
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Guishuang
authors.initials: G
authors.lastname: Li
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Chen
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Jifu
authors.initials: J
authors.lastname: Li
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Fengshuang
authors.initials: F
authors.lastname: An
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 3. Fine Arts School of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.affiliation: 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; ; 2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000328:Adult; D017668:Age of Onset; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000473:pathology; D048909:Diabetes Complications / Q000188:drug therapy* / Q000473:pathology; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000473:pathology; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020123:Sirolimus / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D020123:Sirolimus
keywords: diabetes; drug-eluting stent; early onset coronary artery disease; family history; risk factor.