title: Neurolymphomatosis in three horses with multicentric T-cell-rich B-cell lymphoma.
abstract: Neurolymphomatosis is a rare manifestation of lymphoma and is characterized by neoplastic infiltration of the peripheral nervous system. The present report describes neoplastic infiltration of peripheral nerves in three horses with multicentric lymphoma. Immunohistochemistry revealed the presence of CD79a(+) lymphoblastic cells and well-differentiated CD3(+) T cells, characteristic of T-cell-rich B-cell lymphoma in all cases. Nerve infiltration by lymphoma is rare, but should be considered as a differential diagnosis for peripheral neuropathy in horses with lymphoma.
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, D-30559 Hanover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Lehmbecker
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, D-30559 Hanover, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Liebing
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, D-30559 Hanover, Germany.
authors.forename: Y
authors.initials: Y
authors.lastname: Barthel
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, D-30559 Hanover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Habierski
authors.affiliation: Clinic for Horses, University of Veterinary Medicine Hannover, Bünteweg 9, D-30559, Hanover, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Cavalleri
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, D-30559 Hanover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Puff
authors.affiliation: Am Waldhof 6, D-24629 Stuvenborn, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Rademacher
authors.affiliation: Tierklinik Telgte GbR, Kiebitzpohl 35, D-48291 Telgte, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Lumpe
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, D-30559 Hanover, Germany. Electronic address: Andreas.Beineke@tiho-hannover.de.
authors.forename: A
authors.initials: A
authors.lastname: Beineke
mesh_terms: D000375:Aging; D000818:Animals; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008380:Marek Disease / Q000473:pathology*
keywords: T-cell-rich B-cell lymphoma; horse; neurolymphomatosis