title: Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature.
abstract: Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist.
authors.affiliation: Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland.
authors.forename: Ali
authors.initials: A
authors.lastname: Dirani
authors.affiliation: Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Matet
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
authors.forename: Talal
authors.initials: T
authors.lastname: Beydoun
authors.affiliation: Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland.
authors.forename: Irmela
authors.initials: I
authors.lastname: Mantel
authors.affiliation: Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland ; Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France ; Inserm UMRS872, Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Paris, France.
authors.forename: Francine
authors.initials: F
authors.lastname: Behar-Cohen
keywords: dome-shaped macula; mineralocorticoid receptor antagonist; serous foveal detachment; treatment