title: Neuronal oscillations in Parkinson's disease.
abstract: Parkinson's Disease (PD), characterized by tremor, rigidity, and bradykinesia, is one of the most prevalent neurodegenerative disorders in the world. The pathological hallmark of PD is the loss of dopaminergic cells in the substantia nigra and other brain regions. The pathophysiological mechanisms by which dopaminergic cell loss leads to the motor manifestations of PD are yet to be fully elucidated. A growing body of evidence has revealed abnormal neuronal oscillations within and between multiple brain regions in PD. Unique oscillatory patterns are associated with specific motor abnormalities in PD. Therapies, such as dopaminergic medication and deep brain stimulation that disrupt these abnormal neuronal oscillatory patterns produce symptomatic improvement in PD patients. These findings emphasize the importance of abnormal neuronal oscillations in the pathophysiology of PD, making the disruption of these oscillatory patterns a promising target in the development of effective PD treatments.
authors.affiliation: Department of Neurosurgery, Wake Forest University.
authors.forename: Mark
authors.initials: M
authors.lastname: Witcher
authors.affiliation: Department of Neurosurgery, Wake Forest University.
authors.forename: Rosalyn
authors.initials: R
authors.lastname: Moran
authors.affiliation: Department of Neurosurgery, Wake Forest University.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Tatter
authors.affiliation: Department of Neurosurgery, Wake Forest University.
authors.forename: Adrian W
authors.initials: AW
authors.lastname: Laxton
mesh_terms: D001479:Basal Ganglia / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000379:methods; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D013788:Thalamus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*
chemical_list: D007980:Levodopa