title: Acute hepatitis C infection in a renal transplant recipient: primacy of the liver or kidney?
abstract: We present a case where a renal transplant recipient contracted chronic hepatitis C virus (HCV) infection post-transplantation. The disease progressed and deteriorated leading to fibrosing cholestatic hepatitis that mandated treatment. Treatment with pegylated interferon α-2a and ribavirin was successful in salvaging the liver and eradicating the virus but as a consequence lead to treatment-resistant acute rejection and loss of the renal allograft.
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
authors.forename: Mohammed Mahdi
authors.identifier: http://orcid.org/0000-0002-3158-8316
authors.initials: MM
authors.lastname: Althaf
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia Internal Medicine Department, Alexandria University, Faculty of Medicine, Alexandria, Egypt.
authors.forename: Mohamed Said
authors.initials: MS
authors.lastname: Abdelsalam
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rashwan
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
authors.forename: Quaid
authors.initials: Q
authors.lastname: Nadri
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D005260:Female; D006084:Graft Rejection / Q000139:chemically induced* / Q000601:surgery; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D057193:Medical Tourism; D009392:Nephrectomy; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000009:adverse effects; D006435:Renal Dialysis; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a