title: [Warfarin effects diminishment by the Clostridium butyricum preparation after cardiac surgery; report of a case].
abstract: A 55-year-old gentleman diagnosed with severe aortic insufficiency and annuloaortic ectasia underwent modified Bentall procedure using mechanical valve. Anticoagulation therapy with warfarin was introduced after surgery, but sufficient anticoagulation effect was not achieved with a large amount of dosage. After discontinuing the use of the Clostridium butyricum preparation on postoperative day 29, sufficient anticoagulationt effect was obtained within several days. Clostridium butyricum might change the vitamin K production in the intestinal bacterial flora and attenuated the anticoagulation effect of warfarin.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Maeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsukui
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Umehara
authors.forename: Shizuko
authors.initials: S
authors.lastname: Iwasa
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Sugiura
authors.forename: Minako
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kawano
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001022:Aortic Valve Insufficiency / Q000601:surgery; D001688:Biological Products / Q000009:adverse effects*; D046972:Clostridium butyricum; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014859:Warfarin / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D001688:Biological Products; D014859:Warfarin