title: Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia.
abstract: BACKGROUND
  The main purpose of this study was to determine the maternal and umbilical cord blood oxidized LDL (oxLDL) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in early- and late-onset preeclampsia (PE).
  
  
  METHODS
  A case-control study was conducted in pregnant women with early-onset (before 34 weeks' gestation n = 19) and late-onset (after 34 weeks' gestation n = 22) PE compared to healthy normotensive pregnant controls (n = 44). Groups were compared for the maternal and umbilical cord plasma oxLDL and serum sLOX-1 levels.
  
  
  RESULTS
  The mean maternal and umbilical cord serum sLOX-1 and plasma oxLDL levels were significantly increased in early- and late-onset PE compared to controls (p < 0.001). When early- and late-onset PE women were compared with serum sLOX-1 levels, the increase was more pronounced in early PE (p < 0.001). However, same comparison is not statistically significant in cord blood for oxLDL where as it is significantly higher in maternal blood for oxLDL in early-onset PE group. Maternal and cord blood oxLDL and sLOX-1 levels are positively correlated with each other; however, they are negatively correlated with fetal weight and gestational age.
  
  
  CONCLUSIONS
  According to our results, maternal and umbilical cord blood levels of oxLDL and sLOX-1 were higher in preeclamptic pregnant. Thus, for the first time it has been shown that oxLDL and sLOX-1 levels were higher in fetal circulation as well as plasma of preeclamptic pregnant. However, sLOX-1 levels seem to be more implying than oxLDL for the differentiation of early and late preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Tuten
authors.forename: H
authors.initials: H
authors.lastname: Erman
authors.forename: G G
authors.initials: GG
authors.lastname: Korkmaz
authors.forename: M
authors.initials: M
authors.lastname: Oncul
authors.forename: R
authors.initials: R
authors.lastname: Gelisgen
authors.forename: V
authors.initials: V
authors.lastname: Sozer
authors.forename: S
authors.initials: S
authors.lastname: Acıkgoz
authors.forename: G
authors.initials: G
authors.lastname: Simsek
authors.forename: H
authors.initials: H
authors.lastname: Uzun
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood; D020567:Fetal Weight; D005865:Gestational Age; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: D008077:Lipoproteins, LDL; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein