title: [Oxidative stress and antioxidant therapy with alpha-lipoic acid inclusion in acute poisoning by herbicide based on 2,4-dichlorphenoxyacetic acid].
abstract: In patients with acute poisoning amine salt herbicide 2,4-D develops oxidative stress with simultaneous inhibition of intracellular and extracellular antioxidant factors. These changes are more pronounced with neurological disorders that occur in conjunction with a toxic damage of liver or heart. The inclusion of a comprehensive detoxification therapy alpha-lipoic acid not only promotes a more pronounced therapeutic effect but also an earlier recourse cytolytic syndrome, a marked recovery of levels of malondialdehyde and indices of antioxidant system (superoxide dismutase and ceruloplasmin) than for patients in the comparison group.
authors.forename: O A
authors.initials: OA
authors.lastname: Kharchenko
authors.forename: H M
authors.initials: HM
authors.lastname: Balan
authors.forename: N N
authors.initials: NN
authors.lastname: Bubalo
authors.forename: T V
authors.initials: TV
authors.lastname: Mymrenko
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000506:poisoning*; D000208:Acute Disease; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006334:Heart Function Tests; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D016272:Occupational Health; D018384:Oxidative Stress / Q000187:drug effects*; D008063:Thioctic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000975:Antioxidants; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D008063:Thioctic Acid