title: MicroRNA Machinery Genes as Novel Biomarkers for Cancer.
abstract: MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University , Wuhan , China.
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Huang
authors.affiliation: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Vibhuti
authors.initials: V
authors.lastname: Srivastava
authors.affiliation: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Subrata
authors.initials: S
authors.lastname: Sen
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University , Wuhan , China.
authors.forename: Song-Mei
authors.initials: SM
authors.lastname: Liu
keywords: alterations; biomarker; cancer; machinery genes; miRNA