title: Giant esophageal gastrointestinal stromal tumor: report of a case.
abstract: Gastrointestinal stromal tumors (GISTs) rarely arise in the esophagus, where carcinoma is the most common malignant neoplasm and leiomyoma is the most common benign tumor. Because of their rarity, the clinical course and treatment of esophageal GISTs are poorly understood. These lesions are generally thought to carry a poor prognosis, making the differential diagnosis of other common mesenchymal neoplasms essential, for both prognostic and therapeutic reasons. We report a case of successfully resected giant esophageal GIST, thought to be the largest resected GIST reported in Japan. The patient was a 65-year-old woman, in whom upper gastrointestinal endoscopy found a 180-mm submucosal tumor in the lower thoracic esophagus, extending just below the aortic arch. We diagnosed esophageal GIST, and the patient underwent middle and lower esophagectomy via left thoracotomy, followed by gastric tube reconstruction. The tumor was resected completely. Histopathological and immunohistochemical staining confirmed that the tumor was a high-risk lesion, and treatment with imatinib was initiated. Computed tomography showed liver metastasis 5 months later, but the patient is doing well 24 months after surgery.
authors.affiliation: Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan, nakanodylan@yahoo.co.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Nakano
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Akutsu
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Shuto
authors.forename: Masaya
authors.initials: M
authors.lastname: Uesato
authors.forename: Tsuguaki
authors.initials: T
authors.lastname: Kono
authors.forename: Isamu
authors.initials: I
authors.lastname: Hoshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Akanuma
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Maruyama
authors.forename: Yuka
authors.initials: Y
authors.lastname: Isozaki
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D001549:Benzamides / Q000008:administration & dosage; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000601:surgery*; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000556:secondary; D010879:Piperazines / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D019651:Plastic Surgery Procedures; D013908:Thoracotomy; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate