title: Patient with liver dysfunction while maintained on veno-venous extracorporeal membrane oxygenation should not be overlooked as a potential donor.
abstract: This report describes transplantation of liver allograft from a circulatory death donor who was supported by veno-venous extracorporeal membrane oxygenation (ECMO) for 14 days and presented with severely altered liver functions. Successful liver transplant was done in a patient with hepatocellular carcinoma (HCC) in the background of primary sclerosing cholangitis. There was immediate graft function and uneventful recovery with stable graft function at 1-year follow-up. This case illustrates the ability of veno-venous ECMO to resuscitate organs in the presence of severe dysfunction, and perhaps, lessons from this case may be incorporated to optimize the condition of organs rescued from these marginal donors and exemplify the use of ECMO in normothermic regional perfusion in donors after circulatory death.
authors.affiliation: The Liver Unit, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK.
authors.forename: Moustafa M
authors.initials: MM
authors.lastname: Mourad
authors.forename: Michael
authors.initials: M
authors.lastname: Reay
authors.forename: Paolo
authors.initials: P
authors.lastname: Muiesan
authors.forename: Darius F
authors.initials: DF
authors.lastname: Mirza
authors.forename: M Thamara P R
authors.initials: MT
authors.lastname: Perera
mesh_terms: D000328:Adult; D018450:Disease Progression; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005500:Follow-Up Studies; D006085:Graft Survival; D006323:Heart Arrest / Q000628:therapy; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000601:surgery; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000601:surgery*; D018570:Risk Assessment; D009927:Tissue and Organ Procurement; D066027:Transplant Recipients; D016896:Treatment Outcome
keywords: donor after circulatory death; extracorporeal membrane oxygenation; graft dysfunction; marginal donor