title: [Idiopathic intracranial hypertension and factor V Leiden mutation].
abstract: Activated proteinC resistance is a frequent prothrombotic abnormality. In most cases it is due to factorV Leiden mutation by nucleotide G1691A substitution. This recently described thrombophilic defect of activated proteinC resistance has been postulated to be implicated in the pathogenesis of idiopathic intracranial hypertension (IIH). We report a case of factorV Leiden mutation in association with IIH and their likely link and implication in the management of IIH.
authors.affiliation: Service de médecine interne-endocrinologie-neurologie, hôpital universitaire Taher Sfar Mahdia, Hiboun 5111, Tunisie. Electronic address: younes.samia@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Younes
authors.affiliation: Service de neurologie, hôpital universitaire Fattouma Bourguiba, avenue 1(er)-Juin, Monastir 5000, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Aissi
authors.affiliation: Service de médecine interne-endocrinologie-neurologie, hôpital universitaire Taher Sfar Mahdia, Hiboun 5111, Tunisie.
authors.forename: Y
authors.initials: Y
authors.lastname: Chérif
authors.affiliation: Service de neurologie, hôpital universitaire Fattouma Bourguiba, avenue 1(er)-Juin, Monastir 5000, Tunisie.
authors.forename: N
authors.initials: N
authors.lastname: Daoussi
authors.affiliation: Service de neurologie, hôpital universitaire Fattouma Bourguiba, avenue 1(er)-Juin, Monastir 5000, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Boughammoura
authors.affiliation: Service de neurologie, hôpital universitaire Fattouma Bourguiba, avenue 1(er)-Juin, Monastir 5000, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Frih Ayed
authors.affiliation: Service de médecine interne-endocrinologie-neurologie, hôpital universitaire Taher Sfar Mahdia, Hiboun 5111, Tunisie.
authors.forename: M H
authors.initials: MH
authors.lastname: Sfar
authors.affiliation: Service d'imagerie médicale, hôpital universitaire Taher Sfar Mahdia, Hiboun 5111, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Jerbi
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D020016:Activated Protein C Resistance / Q000150:complications / Q000235:genetics*; D002545:Brain Ischemia / Q000209:etiology; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000188:drug therapy / Q000209:etiology*; D013924:Thrombophlebitis / Q000209:etiology
chemical_list: C095381:factor V Leiden; D005165:Factor V; D000086:Acetazolamide
keywords: Activated protein C resistance; Facteur V Leiden; Factor V Leiden; Hypertension intracrânienne idiopathique; Idiopathic intracranial hypertension; Résistance à la protéine C activée; Thrombose; Thrombosis