title: [Influence of cryoglobulinemic syndrome and insulin resistance on the progression of liver cirrhosis in patients with chronic hepatitis C].
abstract: The article presents the results of analysis of the frequency of detection of cryoglobulinemic syndrome (CGS) and insulin resistance (IR) in patients with HCV-associated liver cirrhosis (LC) depending on its stage. There were also evaluated clinical and laboratory features of the disease. The study involved 72 patients with chronic hepatitis C who were divided into 3 main groups according to the presence of LC. The I group included 32 patients with chronic hepatitis C without LC. The II group consisted of 19 patients with compensated HCV-associated LC and III group included 21 patients with decompensated LC. It was shown that terminal stages of the LC (class B-C by Child-Pugh) are characterized by more frequent presence of IR and CGS with more severe clinical picture, which may be caused not only by the influence of the hepatitis C virus (HCV), but also by the progression of LC.
authors.forename: L O
authors.initials: LO
authors.lastname: Kondratiuk
authors.forename: O V
authors.initials: OV
authors.lastname: Bezrodna
authors.forename: O V
authors.initials: OV
authors.lastname: Kuliesh
mesh_terms: D000328:Adult; D003449:Cryoglobulinemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D003450:Cryoglobulins / Q000032:analysis; D018450:Disease Progression; D005260:Female; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007333:Insulin Resistance; D008103:Liver Cirrhosis / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D003450:Cryoglobulins; D018937:Hepatitis C Antibodies