title: Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering.
abstract: Musculoskeletal regenerative engineering approach using small bioactive molecules in conjunction with advanced materials has emerged as a highly promising strategy for musculoskeletal repair and regeneration. Advanced biomaterials technologies have revealed nanofiber-based scaffolds for musculoskeletal tissue engineering as vehicles for the controlled delivery of small molecule drugs. This review article highlights recent advances in nanofiber-based delivery of small molecules for musculoskeletal regenerative engineering. The article concludes with perspectives on the challenges and future directions.
  
  
  BACKGROUND
  In this review, advances in nanofiber-based delivery of small molecules are discussed from the standpoint of their potential role in musculoskeletal regenerative engineering, highlighting both future directions and current challenges.
authors.affiliation: Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
authors.forename: Erica J
authors.initials: EJ
authors.lastname: Carbone
authors.affiliation: Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Orthopaedic Surgery, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
authors.forename: Clarke
authors.initials: C
authors.lastname: Nelson
authors.affiliation: Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
authors.forename: Nicole
authors.initials: N
authors.lastname: Henry
authors.affiliation: Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Biomedical Engineering, University of Connecticut, School of Engineering, Storrs, Connecticut 06268. Electronic address: wlo@uchc.edu.
authors.forename: Kevin W-H
authors.initials: KW
authors.lastname: Lo
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D009141:Musculoskeletal System; D057139:Nanofibers / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials
keywords: Drug delivery; Musculoskeletal disorders; Nanofibers; Small molecules; Tissue engineering