title: Epigenetic modifier-induced biosynthesis of novel acetylenic sterols from Cladosporium colocasiae.
abstract: The addition of an HDAC inhibitor, suberoylanilide hydroxamic acid (SBHA), to the culture medium of Cladosporium colocasiae, dramatically altered its metabolic profiles. Analysis of the culture broth extract led to the isolation of two new acetylenic sterols (1-2). The isolated compounds were further evaluated for their cytotoxic and antibacterial activities. Compound 1 showed activity against Bacillus subtilis, affording a zone of inhibition of 12mm at 100μg/disk. However, none of them showed noticeable growth inhibitory effects.
authors.affiliation: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. Electronic address: liudongze0923@sina.com.
authors.forename: Dong-Ze
authors.initials: DZ
authors.lastname: Liu
authors.affiliation: Northeast Agricultural University, Harbin 150030, China.
authors.forename: Bo-Wen
authors.initials: BW
authors.lastname: Liang
authors.affiliation: Ocean University of China, Qingdao 266003, China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Li
authors.affiliation: Ocean University of China, Qingdao 266003, China.
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Yu
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D002963:Cladosporium / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D013261:Sterols / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D006877:Hydroxamic Acids; D013261:Sterols; C528828:suberoyl bis-hydroxamic acid
keywords: Biosynthesis; Cladosporium colocasiae; Epigenetic modifier