title: Placement of a duodenal stents bridge the duodenal papilla may predispose to acute pancreatitis.
abstract: OBJECTIVE
  To retrospective evaluate the incidence, predictive factors, and management of acute pancreatitis after placement of duodenal stent in patients with malignant gastroduodenal obstruction.
  
  
  METHODS
  Among 242 patients with symptomatic malignant gastroduodenal obstruction successfully treated with duodenal stent placement, acute pancreatitis occurred in 10 (4.1%) of the patients 1-7 days after stent placement. The variables were analyzed. Univariate and multivariate analysis was performed to evaluate factors predictive of acute pancreatitis. Management of acute pancreatitis also was evaluated.
  
  
  RESULTS
  All patients with acute pancreatitis were presented with abdominal pain and distention with vomiting 1-7 days after stent placement, in which 7 patients developed acute janudice. Four patients were cured by fasting and intravenous nutrition, and the remaining 6 cases were managed with percutaneous cholangiography and drain placement (PTCD). Univariate analysis showed acute pancreatitis was associated with location in the descending duodenum (p = 0.001) and stent bridge the duodenal papilla (p < 0.001). Multivariate analysis exhibited that the presence of stent bridged the duodenal papilla (odds ratio (OR), 18.48; 95% CI, 2.298-148.48; p = 0.006) was independent predictors of acute pancreatitis.
  
  
  CONCLUSIONS
  Acute pancreatitis is an uncommon early complication of placement of duodenal stents in patients with malignant gastroduodenal obstruction. Acute pancreatitis occurred most commonly in descending duodenum, and in patients with stent bridged the duodenal papilla. Stent bridged the duodenal papilla may be the most important predictors for acute pancreatitis. Acute pancreatitis can be managed conservatively or by PTCD when developed to acute jaundice.
authors.forename: Shi-Yi
authors.initials: SY
authors.lastname: Liu
authors.forename: Ai-Wu
authors.initials: AW
authors.lastname: Mao
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Jia
authors.forename: Zhen-Lei
authors.initials: ZL
authors.lastname: Wang
authors.forename: Hao-Sheng
authors.initials: HS
authors.lastname: Jiang
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Yin
mesh_terms: D000208:Acute Disease; D000368:Aged; D000704:Analysis of Variance; D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D004379:Duodenal Neoplasms / Q000601:surgery; D004380:Duodenal Obstruction / Q000601:surgery; D004386:Duodenum / Q000601:surgery*; D005260:Female; D006801:Humans; D007565:Jaundice; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D013274:Stomach Neoplasms / Q000601:surgery