title: Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.
abstract: Type 1 phototherapeutic agents based on diarylamines were assessed for free radical generation and evaluated in vitro for cell death efficacy in the U937 leukemia cancer cell line. All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance (ESR) spectroscopy. Among the diarylamines, the most potent compounds were acridan (4) and 9-phenylacridan (5), with IC50 values of 0.68 μM and 0.17 μM, respectively.
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Raghavan
authors.initials: R
authors.lastname: Rajagopalan
authors.affiliation: Department of Chemistry, Washington University , 1 Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Tien-Sung
authors.initials: TS
authors.lastname: Lin
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Amolkumar S
authors.initials: AS
authors.lastname: Karwa
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Amruta R
authors.initials: AR
authors.lastname: Poreddy
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Bethel
authors.initials: B
authors.lastname: Asmelash
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Dorshow
keywords: Diarylamines; ESR; ROS; photosensitizers; radicals; type 1; type 2