title: Delivering three punches to knockout intracellular bacteria.
abstract: Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Narni-Mancinelli
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France; Service d'Immunologie, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13285 Marseille, France. Electronic address: vivier@ciml.univ-mrs.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D001424:Bacterial Infections / Q000276:immunology*; D004926:Escherichia coli; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008089:Listeria monocytogenes; D013211:Staphylococcus aureus
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; C075005:GNLY protein, human