title: In utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.
abstract: In utero exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial-specific IgG subclass response in neonates and their correlation with plasma levels IL-10 and interferon-γ, 145 pairs of mothers and their respective cord bloods were examined. Transplacental transfer of circulating filarial antigen (CFA) was observed in 34·8% cord bloods from CFA positive mothers. Filarial-specific IgG1, IgG2 and IgG4 responses of cord bloods were found to be positively correlated with CFA of mothers. In contrast, IgG3 responses negatively correlated with CFA of mothers. The % of similarity of recognition pattern in the cord blood with maternal blood was high for IgG3 response than IgG4 in all three groups. An increased levels of IL-10 and decreased levels of interferon gamma (IFN-γ) were observed in cord blood of infected mothers. Interferon gamma was positively correlated with IgG3 and negatively correlated with IgG4 level. On the other hand, IL-10 was positively correlated with IgG4 and CFA, indicating that cytokines may play a role in modulating the immune responses in cord bloods of sensitized foetus. The findings of the study reveal that in utero tolerance or sensitization may influence the filarial-specific immunity to infection in neonates.
authors.affiliation: Division of Immunology, Regional Medical Research Center (Indian Council of Medical Research), Bhubaneswar, Odisha, India.
authors.forename: K G
authors.initials: KG
authors.lastname: Achary
authors.forename: N N
authors.initials: NN
authors.lastname: Mandal
authors.forename: S
authors.initials: S
authors.lastname: Mishra
authors.forename: R
authors.initials: R
authors.lastname: Mishra
authors.forename: S S
authors.initials: SS
authors.lastname: Sarangi
authors.forename: A K
authors.initials: AK
authors.lastname: Satapathy
authors.forename: S K
authors.initials: SK
authors.lastname: Kar
authors.forename: M S
authors.initials: MS
authors.lastname: Bal
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004605:Elephantiasis, Filarial; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005368:Filariasis / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007108:Immune Tolerance; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014958:Wuchereria bancrofti / Q000276:immunology; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: IgG3; IgG4; circulating filarial antigen; filariasis; interferon gamma; maternal filarial infection