title: Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline that is a growing public health crisis with a prevalence projected to more than double in the next 20 years. Sleep is frequently impaired in individuals with AD. Further, recent studies have linked numerous age-related sleep disturbances such as poor sleep efficiency and sleep apnea, to future risk of cognitive impairment. Aggregation of amyloid-β (Aβ) into extracellular plaques in the brain is a key step in AD pathogenesis and likely begins 20 years before the onset of dementia. Aβ concentrations in both humans and mouse models show Aβ concentrations rise during wakefulness and fall during sleep, that is, an Aβ diurnal pattern. There is evidence in animal models that changes in sleep time alter Aβ deposition, suggesting that sleep may play a role in AD pathogenesis. A hypothetical model for the role of sleep and the Aβ diurnal pattern in AD pathogenesis is proposed.
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: luceyb@neuro.wustl.edu.
authors.forename: Brendan P
authors.initials: BP
authors.lastname: Lucey
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Bateman
mesh_terms: D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D058225:Plaque, Amyloid / Q000209:etiology / Q000378:metabolism; D012306:Risk; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000150:complications*; D012893:Sleep Wake Disorders / Q000150:complications*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer's disease; Amyloid-β; Diurnal pattern; Sleep