title: Function and interaction of the coupled genes responsible for Pik-h encoded rice blast resistance.
abstract: Pik-h, an allele of Pik, confers resistance against the rice blast pathogen Magnaporthe oryzae. Its positional cloning has shown that it comprises a pair of NBS-LRR genes, Pikh-1 and Pikh-2. While Pikh-1 appears to be constitutively transcribed, the transcript abundance of Pikh-2 responds to pathogen challenge. The Pikh-1 CC (coiled coil) domain interacts directly with both AvrPik-h and Pikh-2. Transient expression assays demonstrated that Pikh-2 mediates the initiation of the host defence response. Nucleocytoplasmic partitioning of both Pikh-1 and Pikh-2 is required for their functionalities. In a proposed mechanistic model of Pik-h resistance, it is suggested that Pikh-1 acts as an adaptor between AvrPik-h and Pikh-2, while Pikh-2 transduces the signal to trigger Pik-h-specific resistance.
authors.affiliation: National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory for Microbe Signals and Crop Disease Control, South China Agricultural University, Guangzhou, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhai
authors.affiliation: National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory for Microbe Signals and Crop Disease Control, South China Agricultural University, Guangzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.affiliation: National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory for Microbe Signals and Crop Disease Control, South China Agricultural University, Guangzhou, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Lin
authors.affiliation: National Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.affiliation: National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory for Microbe Signals and Crop Disease Control, South China Agricultural University, Guangzhou, China.
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Dong
authors.affiliation: National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory for Microbe Signals and Crop Disease Control, South China Agricultural University, Guangzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory for Microbe Signals and Crop Disease Control, South China Agricultural University, Guangzhou, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Pan
mesh_terms: D060467:Disease Resistance / Q000235:genetics* / Q000276:immunology; D017343:Genes, Plant / Q000235:genetics*; D007113:Immunity, Innate / Q000235:genetics; D020082:Magnaporthe; D012275:Oryza / Q000235:genetics* / Q000276:immunology; D010935:Plant Diseases / Q000235:genetics*