title: Infantile myofibromatosis: a series of 28 cases.
abstract: BACKGROUND
  Infantile myofibromatosis (IM) is a rare disorder of fibroblastic/myofibroblastic proliferation in children.
  
  
  OBJECTIVE
  We sought to document common and unusual characteristics of patients with IM.
  
  
  METHODS
  This was a retrospective study of 28 children diagnosed with histopathologically confirmed IM between 1992 and 2012. Epidemiologic, clinical, and treatment data were reviewed.
  
  
  RESULTS
  IM was more frequent in boys (60.8%). Skin lesions were congenital in 64.3% of cases. The solitary form accounted for 50% of cases. Most nodules were painless, arising in cutaneous or subcutaneous tissue. The multicentric form accounted for 39% of cases; the skin, subcutaneous tissue, or muscle was involved in 97.8% of cases, and the bones in 50% of cases. The generalized form had a mortality rate of 33% (one-third of cases). Multicentric and generalized forms regressed spontaneously; severe local complications were observed, and late recurrent nodules developed in a few cases.
  
  
  CONCLUSIONS
  The retrospective review and the ascertainment of patients (from the departments of obstetrics and pediatrics) may have introduced bias in the analysis of severity of the different forms of IM.
  
  
  CONCLUSIONS
  The diagnosis of IM must be confirmed histopathologically because the clinical presentation can be misleading. The prognosis is usually good, although local morbidity can occur. The generalized and multicentric forms merit long-term follow-up.
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Jacob
authors.initials: J
authors.lastname: Mashiah
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France; Reference Centre for Genodermatoses and Rare Skin Diseases (MAGEC), Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France; Université Paris Descartes - Sorbonne Paris Cité, Institut Imagine, Paris, France.
authors.forename: Smail
authors.initials: S
authors.lastname: Hadj-Rabia
authors.affiliation: Department of Dermatology, Centre Hospitalier de Caen, Caen, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Dompmartin
authors.affiliation: Department of Pediatrics, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Harroche
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Etty
authors.initials: E
authors.lastname: Laloum-Grynberg
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Wolter
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Amoric
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hamel-Teillac
authors.affiliation: Department of Surgery, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Guero
authors.affiliation: Reference Centre for Genodermatoses and Rare Skin Diseases (MAGEC), Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France; Department of Pathology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fraitag
authors.affiliation: Department of Dermatology, Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France; Reference Centre for Genodermatoses and Rare Skin Diseases (MAGEC), Groupe Hospitalier Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Paris, France; Université Paris Descartes - Sorbonne Paris Cité, Institut Imagine, Paris, France. Electronic address: christine.bodemer@nck.aphp.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Bodemer
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018224:Myofibromatosis / Q000151:congenital* / Q000473:pathology; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012737:Sex Factors; D012878:Skin Neoplasms / Q000151:congenital / Q000473:pathology*
keywords: good prognosis; infantile myofibromatosis; long-term follow-up; pediatrics; systemic complications; tumoral lesions