title: Quality of life and mild cognitive impairment in early Parkinson's disease: does subtype matter?
abstract: We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia. Participants completed neuropsychological tests of attention, executive function, visuospatial function, memory, and language, and reported QoL using the Parkinson's Disease Questionnaire. Impairments were most common in executive function, memory and attention. MCI subtypes were classified according to Movement Disorder Society Task Force criteria. More severe cognitive impairment was associated with poorer quality of life (p = 0.01), but subtype of impairment was not (p > 0.10), suggesting that the nature of cognitive impairment is less significant than its severity.
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Rachael A
authors.initials: RA
authors.lastname: Lawson
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Yarnall
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Duncan
authors.affiliation: Griffith Health Institute & School of Medicine, Griffith University, Gold Coast, Australia.
authors.forename: Tien K
authors.initials: TK
authors.lastname: Khoo
authors.affiliation: John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
authors.forename: David P
authors.initials: DP
authors.lastname: Breen
authors.affiliation: John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Barker
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Collerton
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Burn
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000145:classification / Q000150:complications / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000453:epidemiology* / Q000523:psychology*; D011788:Quality of Life
keywords: Parkinson's disease; mild cognitive impairment; quality of life; subtypes