title: Role of the glucose tolerance test as a predictor of preeclampsia.
abstract: OBJECTIVE
  To determine whether oral glucose tolerance tests (OGTT) play a role as predictors of preeclampsia (PET) in pregnant women.
  
  
  METHODS
  A retrospective case-control study was conducted in 2,002 singleton pregnancies that had a uterine artery (UtA) Doppler at 22-25 weeks and an OGTT. The UtA Doppler and OGTT were adjusted based on maternal characteristics, and the results were expressed as multiples of the expected normal median and compared between groups. Logistic regression analysis was used to determine whether maternal characteristics, OGTT, and UtA Doppler significantly contribute to the prediction of early- (<34 weeks), intermediate- (34-37 weeks), or late-onset (>37 weeks) PET. The performance of the screening was determined by ROC curves.
  
  
  RESULTS
  Women who developed PET were characterized by an older maternal age, an increased body mass index, and an altered UtA Doppler. The group with intermediate-onset PET was the only one associated with higher 2-hour OGTT levels compared to controls. Combined models were developed via logistic regression analysis using maternal characteristics, UtA Doppler, and OGTT to predict PET. These combined models were able to detect around 74, 42, and 21% of women who later developed early-, intermediate-, or late-onset PET, respectively, with only a 5% false-positive rate.
  
  
  CONCLUSIONS
  This study shows that the combination of maternal characteristics, second-trimester UtA Doppler, and OGTT is a predictor of the development of PET in healthy pregnant women.
authors.affiliation: Fetal Medicine Unit, Department of Obstetrics and Gynecology, University of Chile Hospital, Santiago, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Parra-Cordero
authors.forename: A
authors.initials: A
authors.lastname: Sepúlveda-Martínez
authors.forename: J
authors.initials: J
authors.lastname: Preisler
authors.forename: J
authors.initials: J
authors.lastname: Pastén
authors.forename: E
authors.initials: E
authors.lastname: Soto-Chacón
authors.forename: E
authors.initials: E
authors.lastname: Valdés
authors.forename: G
authors.initials: G
authors.lastname: Rencoret
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D016015:Logistic Models; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000453:epidemiology; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology; D012372:ROC Curve; D012189:Retrospective Studies; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging