title: Role of lipid peroxidation products, plasma total antioxidant status, and Cu-, Zn-superoxide dismutase activity as biomarkers of oxidative stress in elderly prediabetics.
abstract: The relationship between hyperglycemia and oxidative stress in diabetes is well known, but the influence of metabolic disturbances recognized as prediabetes, in elderly patients especially, awaits for an explanation.
  
  
  METHODS
  52 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed: waist circumference (WC), body mass index (BMI), percentage of body fat (FAT), and arterial blood pressure. During an oral glucose tolerance test (OGTT) fasting (0') and 120-minute (120') glycemia and insulinemia were determined, and type 2 diabetics (n = 6) were excluded. Subjects were tested for glycated hemoglobin HbA1c, plasma lipids, total antioxidant status (TAS), thiobarbituric acid-reacting substances (TBARS), and activity of erythrocyte superoxide dismutase (SOD-1). According to OGTT results, patients were classified as normoglycemics, (NGT, n = 18) and prediabetics, (PRE, n = 28).
  
  
  RESULTS
  Both groups did not differ with their lipids, FAT, and TBARS. PRE group had higher WC (P < 0.002) and BMI (P < 0.002). Lower SOD-1 activity (P < 0.04) and TAS status (P < 0.04) were found in PRE versus NGT group.
  
  
  CONCLUSIONS
  In elderly prediabetics, SOD-1 and TAS seem to reflect the first symptoms of oxidative stress, while TBARS are later biomarkers of oxidative stress.
authors.affiliation: Teaching Department and Hospital Ward of Internal Diseases, Medical University of Silesia, Żeromskiego 7 Street, 41-902 Bytom, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Dzięgielewska-Gęsiak
authors.affiliation: Department of Clinical Biochemistry and Laboratory Medicine, Poznań University of Medical Sciences, Grunwaldzka 6 Street, 61-702 Poznań, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wysocka
authors.affiliation: Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Przybyszewskiego 49 Street, 60-355 Poznań, Poland ; Neuroimmunology Unit, Polish Academy of Sciences, Przybyszewskiego 49 Street, 60-355 Poznań, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Michalak
authors.affiliation: Teaching Department and Hospital Ward of Internal Diseases, Medical University of Silesia, Żeromskiego 7 Street, 41-902 Bytom, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowakowska-Zajdel
authors.affiliation: Teaching Department and Hospital Ward of Internal Diseases, Medical University of Silesia, Żeromskiego 7 Street, 41-902 Bytom, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Kokot
authors.affiliation: Teaching Department and Hospital Ward of Internal Diseases, Medical University of Silesia, Żeromskiego 7 Street, 41-902 Bytom, Poland.
authors.forename: Małgorzata
authors.identifier: 0000-0001-6562-7072
authors.initials: M
authors.lastname: Muc-Wierzgoń
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D011236:Prediabetic State / Q000378:metabolism* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism*; D055105:Waist Circumference
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D013482:Superoxide Dismutase; C517652:hemoglobin A1c protein, human