title: Decreased white matter integrity in mesial temporal lobe epilepsy: a machine learning approach.
abstract: Statistical analysis on diffusion tensor imaging has been used extensively in mesial temporal lobe epilepsy (mTLE) and most studies report decrease in fractional anisotropy (FA) in multiple white matter regions. However, these findings vary across studies and between regions. Therefore, in this study, we used tract-based spatial statistics along with machine learning approaches to investigate the whole-brain white matter changes between 17 left mTLE patients and 15 right mTLE patients and 34 matched healthy controls. The results showed that the three groups could be distinguished from each other with promising accuracy. Compared with controls, the FA value of the most discriminating voxels was decreased in the ipsilateral limbic system, corpus callosum, and temporal white matter in both patient groups. Compared with right mTLE, left mTLE had decreased FA in the left temporal white matter, whereas right mTLE had decreased FA in the right frontal and temporal white matter, and right posterior corona radiata. These findings not only provide useful information for lateralization of the seizure focus but can also be used as a potential biomarker for the diagnosis and treatment of the mTLE. This may be helpful in assessment of patients with mTLE when no lesion is detected on visual evaluation.
authors.affiliation: aMedical Imaging Center, Nanfang Hospital, Southern Medical University bMedical Imaging Center, Guangdong 999 Brain Hospital, Guangzhou cCollege of Mechatronics and Automation, National University of Defense Technology, Hunan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: An
authors.forename: Peng
authors.initials: P
authors.lastname: Fang
authors.forename: Wensheng
authors.initials: W
authors.lastname: Wang
authors.forename: Zhenyin
authors.initials: Z
authors.lastname: Liu
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
authors.forename: Shijun
authors.initials: S
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D001185:Artificial Intelligence; D015415:Biomarkers; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers