title: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog.
abstract: BACKGROUND
  Squamous cell carcinomas (SCCs) are uncommon, high-grade tumors, predominantly composed of round cells in the prepuce. The aim of this study is to better define the clinicopathologic features of this neoplasm.
  
  
  METHODS
  We conducted cyto-histopathologic analysis on the manifestations of the prepuce SCC by H & E staining in a terrier mix dog. Grossly, tumor was large, multiple erythematous patch, and ulcerated masses frequently affecting the prepuce and deeply invading to distal prepuce out from the ventro-lateral of penis and the tumor covered by a necrotic discharge. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the prepuce comprised of round nuclei, coarse chromatin pattern, distinct nucleoli and nuclear pleomorphism. Furthermore, the neoplastic cells were pleomorphic, round to caudate in shape, exhibiting prominent anisokaryosis and anisocytosis with rare mitotic features. Microscopically, the lesions were predominantly composed of atypical round cells disposed in interlacing fascicles. Frequent findings include keratin formation, horn pearls, mitoses and cellular atypia. The cells showed distinct borders, ranged from polygonal to round or elongate and had moderate amounts of eosinophilic cytoplasm.
  
  
  CONCLUSIONS
  The histopathologic features coupled with the cytopathology findings led to a diagnosis of squamous cell carcinoma. To the authors' knowledge, this is the first time that multiple erythematous plaques have undergone malignant transformation in a terrier mix dog.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5748771971272873.
authors.forename: Javad
authors.initials: J
authors.lastname: Yaghoobi Yeganeh Manesh
authors.forename: Radmehr
authors.initials: R
authors.lastname: Shafiee
authors.forename: Ali
authors.initials: A
authors.lastname: Mohammad Bahrami
authors.forename: Mehdi
authors.initials: M
authors.lastname: Pourzaer
authors.forename: Maryam
authors.initials: M
authors.lastname: Pourzaer
authors.forename: Behnam
authors.initials: B
authors.lastname: Pedram
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran. jjavanbakht60@yahoo.com.
authors.forename: Javad
authors.initials: J
authors.lastname: Javanbakht
authors.forename: Aram
authors.initials: A
authors.lastname: Mokarizadeh
authors.forename: Farshid
authors.initials: F
authors.lastname: Khadivar
mesh_terms: D000818:Animals; D044963:Biopsy, Fine-Needle / Q000662:veterinary; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003581:Cytodiagnosis / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004890:Erythema / Q000473:pathology / Q000662:veterinary; D008297:Male; D008853:Microscopy / Q000662:veterinary; D010412:Penile Neoplasms / Q000473:pathology / Q000662:veterinary*; D010413:Penis / Q000473:pathology*; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*; D013194:Staining and Labeling / Q000662:veterinary; D047368:Tumor Burden