title: Synthesis of C-Pseudonucleosides Bearing Thiazolidin-4-one as a Novel Potential Immunostimulating Agent.
abstract: Several novel C-pseudonucleosides bearing thiazolidin-4-one were synthesized by one-pot three-component condensation using unprotected sugar aldehyde at room temperature, and their effects on T cells, B cells, the cytokine secretion of IL-2, IL-4, and IFN-γ, T cell-associated molecules (CD3, CD4, CD8), and B cell-associated molecules (CD19) were first evaluated. The experimental data demonstrated that such thiazolidin-4-one C-pseudonucleosides hold potential as immunostimulating agents.
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Enkai
authors.initials: E
authors.lastname: Wang
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Gao
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Sinan
authors.initials: S
authors.lastname: Wei
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China ; State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, China.
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Meng
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Pingzhu
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science and Medical School, Hebei University , Baoding 071002, China.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
keywords: C-pseudonucleosides; Immunostimulating agents; thiazolidin-4-one