title: Chromogranin-A levels measured with automated immunoassay.
abstract: Measurement of chromogranin-A (CgA) levels is relevant for the diagnosis of neuroendocrine neoplasms. The use of CgA testing for risk stratification of cardiovascular diseases is also increasing. The objective of our study was to determine the performances and reference values of a novel automated assay for CgA testing. The new method was compared with an enzyme-linked immunosorbent assay. Our results showed that the performances of the automated assay were satisfactory and that the agreement between the two methods was excellent. The automation of CgA testing also reduced the turnaround time of analysis and, therefore, might contribute to a faster delivery of the results to physicians.
authors.affiliation: Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels - Belgium.
authors.forename: Damien
authors.initials: D
authors.lastname: Gruson
authors.forename: Thibault
authors.initials: T
authors.lastname: Lepoutre
authors.forename: Françoise
authors.initials: F
authors.lastname: Smits
mesh_terms: D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods / Q000592:standards; D053379:Chromogranin A / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D057230:Limit of Detection; D012016:Reference Values
chemical_list: D015415:Biomarkers; D053379:Chromogranin A