title: Role of receptors to fibroblast growth factor (FGF) on mesenchymal precursor cells in the realization of regenerative effects of alkaloid songorine.
abstract: We studied the mechanisms of regenerative (wound healing) effects of songorine associated with functional activation of mesenchymal progenitor cells. The key role of FGF receptors on these progenitor cells in the stimulation of realization of their growth potential under the effect of the alkaloid was demonstrated. Under in vitro conditions, the antibodies to FGF receptor abolished the songorine-induced increase in the number of fibroblast colony-forming units in bone marrow cell culture. The intensity of differentiation of mesenchymal precursors remained unchanged.
authors.affiliation: Research Institute of Pharmacology, Siberian Division of the Russian, Academy of Medical Sciences, Tomsk, Russia, zgn@pharm.tsu.ru.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: A A
authors.initials: AA
authors.lastname: Ligacheva
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: E A
authors.initials: EA
authors.lastname: Losev
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'eva
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D000906:Antibodies / Q000494:pharmacology; D002478:Cells, Cultured; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D017468:Receptors, Fibroblast Growth Factor / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects* / Q000235:genetics; D014949:Wounds, Nonpenetrating / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000470:Alkaloids; D000906:Antibodies; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; C057217:songorine