title: Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss.
abstract: OBJECTIVE
  To determine whether the frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss (REPL).
  
  
  METHODS
  Observational cohort study using prospectively collected data.
  
  
  METHODS
  Academic RPL program.
  
  
  METHODS
  A total of 372 women with REPL, defined as ≥2 pregnancy losses<10 weeks, and at least one ultrasound-documented miscarriage with chromosome results.
  
  
  METHODS
  Body mass index (BMI) was measured at the initial consultation and at each subsequent pregnancy. Conventional cytogenetic analysis and, when indicated, microsatellite analysis and/or comparative genomic hybridization was performed.
  
  
  METHODS
  Frequency of euploid miscarriage in obese (BMI≥30 kg/m2) and nonobese (BMI<30 kg/m2) subjects, before and subsequent to REPL evaluation.
  
  
  RESULTS
  There were 578 miscarriages with chromosome results. Of the subjects, 18% were obese at the time of miscarriage. The mean maternal age at miscarriage was similar between the obese and nonobese groups. Due to the high rate of maternal cell contamination in the prior miscarriages, only subsequent miscarriages with chromosome results were included in the primary analysis. Of the 117 subsequent miscarriages, the frequency of an euploid miscarriage among obese women was 58% compared with 37% of nonobese women (relative risk=1.63; 95% confidence interval 1.08-2.47).
  
  
  CONCLUSIONS
  Obese women with REPL have an increased frequency of euploid miscarriage, which is a known risk factor for subsequent miscarriage.
authors.affiliation: University of Chicago Recurrent Pregnancy Loss Program, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois; Division of Reproductive Endocrinology & Infertility, Washington University, St. Louis, Missouri.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Boots
authors.affiliation: University of Chicago Recurrent Pregnancy Loss Program, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois; Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: Lia A
authors.initials: LA
authors.lastname: Bernardi
authors.affiliation: University of Chicago Recurrent Pregnancy Loss Program, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois; Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois. Electronic address: msteph@uic.edu.
authors.forename: Mary D
authors.initials: MD
authors.lastname: Stephenson
mesh_terms: D000026:Abortion, Habitual / Q000208:ethnology / Q000235:genetics*; D000328:Adult; D015992:Body Mass Index; D002641:Chicago / Q000453:epidemiology; D055028:Comparative Genomic Hybridization; D020732:Cytogenetic Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008423:Maternal Age; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology; D010641:Phenotype; D011003:Ploidies; D011247:Pregnancy; D044469:Racial Groups / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors
keywords: Obesity; euploid; karyotype; recurrent miscarriage; recurrent pregnancy loss