title: Ultrasonic assisted preparation of lanthanide-oleate complexes for the synthesis of multifunctional monodisperse upconversion nanoparticles for multimodal imaging.
abstract: The synthesis of multifunctional monodisperse upconversion nanoparticles (UCNPs) of high quality is highly desired for bioimaging. Lanthanide-oleate complexes are excellent precursors for the synthesis of high quality UCNPs with controllable size and shape. In this work, lanthanide-oleate complexes were prepared by an ultrasonic assisted procedure, and used as precursors for further synthesis of multifunctional monodisperse NaYF4:59%Yb(3+),0.5% Tm(3+)@NaYF₄:20%Gd(3+) nanoparticles without the need for further purification. Heavy doping of Yb(3+) in the core and incorporation of Gd(3+) in the shell made the UCNPs promising for upconversion luminescence (UCL), magnetic resonance (MR) and computed tomography (CT) multimodal imaging. The nanoparticles were further functionalized with bombesin peptide for in vivo UCL/MR/CT imaging of prostate tumors.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology (Nankai University), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Research Center for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China. xpyan@nankai.edu.cn.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Tang
authors.forename: Jianing
authors.initials: J
authors.lastname: Wang
authors.forename: Cheng-Xiong
authors.initials: CX
authors.lastname: Yang
authors.forename: Lu-Xi
authors.initials: LX
authors.lastname: Dong
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Yan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D019301:Oleic Acid / Q000737:chemistry*; D013010:Sonication; D014057:Tomography, X-Ray Computed; D014183:Transplantation, Heterologous; D015019:Yttrium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; C525362:sodium yttriumtetrafluoride; D019301:Oleic Acid; D015019:Yttrium; D005682:Gadolinium; D005459:Fluorides