title: Risks of decreased renal function and increased albuminuria for glycemic status and metabolic syndrome components: Taichung Community Health study.
abstract: BACKGROUND
  The objective of this study was to assess the association of glycemic status and decreased renal function as determined by estimated glomerular filtration rate (eGFR) and albuminuria in an adult Taiwanese metropolitan population.
  
  
  METHODS
  We did a cross-sectional survey in a representative sample of 2,350 Taiwanese adults aged 40 years and over living in a metropolitan city in Taiwan from 2004 to 2005. Glycemic status was classified as normal glycemia, hyperglycemia, and type 2 diabetes (T2D). Renal function was assessed with eGFR using modified Modification of Diet in Renal Disease Study equation for Chinese. Albuminuria was determined by the urinary albumin-creatinine ratio. Decreased renal function was defined as eGFR <60 mL/min/1.73 m(2) and albuminuria as the albumin-creatinine ratio >30 mg g(-1) creatinine.
  
  
  RESULTS
  593 (25.23%) had hyperglycemia and 287 (12.21%) had T2D. As glycemia level increased, the prevalence of albuminuria and decreased eGFR increased. After adjustment, T2D was associated with an OR of 2.93 (95% CI: 2.11-4.07) for albuminuria, and an OR of 2.05 (95% CI: 1.18-3.58) for decreased eGFR.
  
  
  CONCLUSIONS
  In a representative sample from a metropolitan city in Taiwan, T2D was associated with albuminuria and decreased eGFR.
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan ; School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ; Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.affiliation: School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ; Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Chia-Ing
authors.initials: CI
authors.lastname: Li
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan ; School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ; Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Chiu-Shong
authors.initials: CS
authors.lastname: Liu
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan ; School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan ; School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Chih-Hsueh
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan ; School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Ming-May
authors.initials: MM
authors.lastname: Lai
authors.affiliation: Medical College, Department of Psychiatry, Medical College, National Cheng Kung University, Tainan 70101, Taiwan ; Bristol-Myers Squibb Ltd, Global Development & Medical Affair, Taipei 10586, Taiwan.
authors.forename: Yih-Dar
authors.initials: YD
authors.lastname: Lee
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Ching-Chu
authors.identifier: 0000-0002-3823-1969
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Chuan-Wei
authors.initials: CW
authors.lastname: Yang
authors.affiliation: Graduate Institute of Biostatistics, College of Management, China Medical University, Taichung 40402, Taiwan ; Department of Healthcare Administration, College of Health Science, Asia University, Taichung 41354, Taiwan.
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
mesh_terms: D000368:Aged; D000418:Albumins / Q000378:metabolism; D000419:Albuminuria / Q000209:etiology* / Q000503:physiopathology*; D003404:Creatinine / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D016021:Epidemiologic Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000503:physiopathology*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000418:Albumins; D003404:Creatinine