title: Adipokines NUCB2/nesfatin-1 and visfatin as novel inflammatory factors in chronic obstructive pulmonary disease.
abstract: COPD (chronic obstructive pulmonary disease) is a common lung disease characterized by airflow limitation and systemic inflammation. Recently, adipose tissue mediated inflammation has gathered increasing interest in the pathogenesis of the disease. In this study, we investigated the role of novel adipocytokines nesfatin-1 and visfatin in COPD by measuring if they are associated with the inflammatory activity, lung function, or symptoms. Plasma levels of NUCB2/nesfatin-1 and visfatin were measured together with IL-6, IL-8, TNF- α , and MMP-9, lung function, exhaled nitric oxide, and symptoms in 43 male patients with emphysematous COPD. The measurements were repeated in a subgroup of the patients after four weeks' treatment with inhaled fluticasone. Both visfatin and NUCB2/nesfatin-1 correlated positively with plasma levels of IL-6 (r = 0.341, P = 0.027 and rho = 0.401, P = 0.008, resp.) and TNF- α (r = 0.305, P = 0.052 and rho = 0.329, P = 0.033, resp.) and NUCB2/nesfatin-1 also with IL-8 (rho = 0.321, P = 0.036) in patients with COPD. Further, the plasma levels of visfatin correlated negatively with pulmonary diffusing capacity (r = -0.369, P = 0.016). Neither of the adipokines was affected by fluticasone treatment and they were not related to steroid-responsiveness. The present results introduce adipocytokines NUCB2/nesfatin-1 and visfatin as novel factors associated with systemic inflammation in COPD and suggest that visfatin may mediate impaired pulmonary diffusing capacity.
authors.affiliation: Department of Respiratory Medicine, Tampere University Hospital, PL 2000, 33521 Tampere, Finland ; The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland.
authors.forename: Sirpa
authors.identifier: 0000-0002-1324-6718
authors.initials: S
authors.lastname: Leivo-Korpela
authors.affiliation: The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland ; Allergy Centre, Tampere University Hospital, PL 2000, 33521 Tampere, Finland.
authors.forename: Lauri
authors.initials: L
authors.lastname: Lehtimäki
authors.affiliation: The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland.
authors.forename: Mari
authors.initials: M
authors.lastname: Hämälainen
authors.affiliation: The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland.
authors.forename: Katriina
authors.identifier: 0000-0003-0017-1291
authors.initials: K
authors.lastname: Vuolteenaho
authors.affiliation: Medical Imaging Centre, Tampere University Hospital, PL 2000, 33521 Tampere, Finland.
authors.forename: Lea
authors.identifier: 0000-0001-5321-086X
authors.initials: L
authors.lastname: Kööbi
authors.affiliation: Medical Imaging Centre, Tampere University Hospital, PL 2000, 33521 Tampere, Finland.
authors.forename: Ritva
authors.initials: R
authors.lastname: Järvenpää
authors.affiliation: Department of Respiratory Medicine, Seinäjoki Central Hospital, 60220 Seinäjoki, Finland.
authors.forename: Hannu
authors.identifier: 0000-0001-5258-0906
authors.initials: H
authors.lastname: Kankaanranta
authors.affiliation: Department of Respiratory Medicine, Tampere University Hospital, PL 2000, 33521 Tampere, Finland.
authors.forename: Seppo
authors.initials: S
authors.lastname: Saarelainen
authors.affiliation: The Immunopharmacology Research Group, School of Medicine, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland.
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
mesh_terms: D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000737:chemistry; D015415:Biomarkers / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D000068298:Fluticasone; D005541:Forced Expiratory Volume; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008168:Lung / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009569:Nitric Oxide / Q000737:chemistry; D000080866:Nucleobindins; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000730:Androstadienes; D015415:Biomarkers; D002135:Calcium-Binding Proteins; D016207:Cytokines; D004268:DNA-Binding Proteins; D015850:Interleukin-6; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D000068298:Fluticasone; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human