title: Heteronuclear Gd-(99m)Tc Complex of DTPA-Bis(histidylamide) Conjugate as a Bimodal MR/SPECT Imaging Probe.
abstract: The work describes the synthesis and in vivo application of heterotrimetallic complexes of the type {Gd(H2O)[(M(H2O)(CO)3)2(1)]} {1 = DTPA-bis(histidyl-amide); M = Re (3a); (99m)Tc (3b)} for dual modality MR/SPECT imaging. Here, the DTPA-bis(histidylamide) conjugate functions as a trinucleating chelate incorporating Gd in the DTPA core with Re or (99m)Tc in the pair of histidylamide side arms. The two complexes are chemically equivalent as revealed by HPLC, and their "cocktail mixture" (3a + 3b) has demonstrated itself to be essentially a single bimodal imaging probe. The present system has thus overcome the sensitivity difference problem between MRI and SPECT and paved the way for practical applications.
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
authors.forename: Ji-Ae
authors.initials: JA
authors.lastname: Park
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Medical & Biological Engineering, Kyungpook National University, Daegu 700-422, Korea.
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
authors.forename: Wonho
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
authors.forename: Sang Moo
authors.initials: SM
authors.lastname: Lim
authors.affiliation: Department of Medical & Biological Engineering, Kyungpook National University, Daegu 700-422, Korea.
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Korea.
authors.forename: Tae-Jeong
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
keywords: MR/SPECT; cocktail mixture; dual modality; heterotrimetallic Gd-[99mTc]2/[Re]2 complexes; imaging probe