title: Recurrence risk ratio of siblings and familial aggregation of the metabolic syndrome among Tehranian population.
abstract: BACKGROUND
  In this study, we aimed to determine the extent of possible genetic influence on cardio-metabolic risk factors, evaluate the familial aggregation of MetS and estimate the siblings' recurrence risk ratios in a Tehrani population.
  
  
  METHODS
  In a cross-sectional observational study, we made anthropometric, blood pressure, and biochemical measurements in each member of 566 Tehrani nuclear families.
  
  
  RESULTS
  Grandmothers had the highest incidence of atherosclerotic risk factors. Four factors were found which accounted for 77.7% of the overall variance. Recurrence risk ratio among siblings was 5.61 (95% conﬁdence interval [CI]: 3.15-9.97). The adjusted odds ratio (OR) of proband's MetS status was 1.33 (95% CI: 1.06-1.67). The adjusted OR for the four factors to predict MetS were all signiﬁcant, with obesity having the highest risk (OR: 7.50, CI: 5.91-9.52), followed by dyslipidemia/hyperglycemia (OR: 4.86, CI: 4.03-5.87), and blood pressure (OR: 4.20, CI: 3.51-5.02).
  
  
  CONCLUSIONS
  A high risk of MetS (five-fold) was found in siblings with MetS proband. Moreover, findings confirm the importance of obesity for the aggregation of MetS by nearly seven-fold in the study population.
authors.affiliation: Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.daneshpour@endocrine.ac.ir.
authors.forename: Maryam
authors.initials: M
authors.lastname: Zarkesh
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Hosseinpanah
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Barzin
authors.affiliation: Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Hosseinzadeh
authors.affiliation: Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Guity
authors.affiliation: Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam Sadat
authors.initials: MS
authors.lastname: Daneshpour
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Tehran, Iran.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005190:Family; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D012008:Recurrence; D035781:Siblings