title: [Bing-Neel syndrome: Report of 4 cases and literature review].
abstract: BACKGROUND
  Neurological manifestations during Waldenstrom disease are common and are usually related to immune peripheral neuropathy or serum hyperviscosity syndrome. The infiltration of the central nervous system by the lymphoproliferative syndrome is known as the Bing-Neel syndrome. This extremely rare entity remains poorly described in the literature.
  
  
  METHODS
  We report on 4 cases of patients for whom central neurological disorders led to the diagnosis of a Bing and Neel syndrome. These four cases illustrate different clinical presentations, diagnosis, therapeutic options, and outcome in this syndrome. Based on our literature review, we discuss about these differences.
  
  
  CONCLUSIONS
  The polymorphic clinical manifestations of Bing and Neel syndrome can mimic many diagnoses. However, it may be necessary to consider this diagnosis. Cerebrospinal fluid analysis and MRI may allow rapid diagnosis or guide a biopsy. Prolonged remissions are possible with appropriate treatment.
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France. Electronic address: laurys84@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Boudin
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France.
authors.forename: E
authors.initials: E
authors.lastname: Romeo
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France.
authors.forename: E
authors.initials: E
authors.lastname: Mavrovi
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France.
authors.forename: P
authors.initials: P
authors.lastname: Tsitsi Nding
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France.
authors.forename: J-S
authors.initials: JS
authors.lastname: Blade
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: de Jaureguiberry
authors.affiliation: Service de médecine interne - oncologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France.
authors.forename: O
authors.initials: O
authors.lastname: Gisserot
mesh_terms: D000368:Aged; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000175:diagnosis
keywords: Bing and Neel syndrome; Central nervous system; Maladie de Waldenström; Syndrome de Bing et Neel; Système nerveux central; Waldenstrom's macroglobulinemia