title: Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.
abstract: Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea.
authors.forename: Il Hak
authors.initials: IH
authors.lastname: Bae
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea.
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Choi
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea.
authors.forename: Chieyeon
authors.initials: C
authors.lastname: Chough
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea.
authors.forename: Sun Ju
authors.initials: SJ
authors.lastname: Keum
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea.
authors.forename: Heesun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea.
authors.forename: Sung Key
authors.initials: SK
authors.lastname: Jang
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea.
authors.forename: B Moon
authors.initials: BM
authors.lastname: Kim
keywords: HCV; NS5A inhibitor; antiviral agent; benzidine; structure−activity relationship