title: Three consecutive days of interval runs to exhaustion affects lymphocyte subset apoptosis and migration.
abstract: This investigation assessed the lymphocyte subset response to three days of intermittent run exercise to exhaustion. Twelve healthy college-aged males (n = 8) and females (n = 4) (age = 26 ± 4 years; height = 170.2 ± 10 cm; body mass = 75 ± 18 kg) completed an exertion test (maximal running speed and VO2max) and later performed three consecutive days of an intermittent run protocol to exhaustion (30 sec at maximal running speed and 30 sec at half of the maximal running speed). Blood was collected before exercise (PRE) and immediately following the treadmill bout (POST) each day. When the absolute change from baseline was evaluated (i. e., Δ baseline), a significant change in CD4+ and CD8+ for CX3CR1 cells was observed by completion of the third day. Significant changes in both apoptosis and migration were observed following two consecutive days in CD19+ lymphocytes, and the influence of apoptosis persisted following the third day. Given these lymphocyte responses, it is recommended that a rest day be incorporated following two consecutive days of a high-intensity intermittent run program to minimize immune cell modulations and reduce potential susceptibility.
authors.affiliation: Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, P.O. Box 453034, Las Vegas, NV 89154-3034, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Navalta
authors.affiliation: Graduation Program on Physical Education, Catholic University of Brasilia, 71966-700 Brasilia, DF, Brazil.
authors.forename: Ramires Alsamir
authors.initials: RA
authors.lastname: Tibana
authors.affiliation: Department of Kinesiology, Recreation and Sport, Western Kentucky University, Bowling Green, KY 42101-1089, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Fedor
authors.affiliation: College of Physical Education, University of Brasilia, 72-910-910 Brasilia, DF, Brazil.
authors.forename: Amilton
authors.identifier: 0000-0002-6027-4367
authors.initials: A
authors.lastname: Vieira
authors.affiliation: Graduation Program on Physical Education, Catholic University of Brasilia, 71966-700 Brasilia, DF, Brazil.
authors.forename: Jonato
authors.identifier: 0000-0003-0399-8817
authors.initials: J
authors.lastname: Prestes
mesh_terms: D000328:Adult; D018941:Antigens, CD19 / Q000378:metabolism; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002465:Cell Movement; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000276:immunology*; D005260:Female; D006801:Humans; D016131:Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*; D008297:Male; D013997:Time Factors
chemical_list: D018941:Antigens, CD19