title: Epstein-Barr virus, the germinal centre and the development of Hodgkin's lymphoma.
abstract: The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.
authors.affiliation: Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Ghada
authors.initials: G
authors.lastname: Mohamed
authors.affiliation: Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Katerina
authors.initials: K
authors.lastname: Vrzalikova
authors.affiliation: Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Fathima Zumla
authors.initials: FZ
authors.lastname: Cader
authors.affiliation: Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Martina
authors.initials: M
authors.lastname: Vockerodt
authors.affiliation: Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Eszter
authors.initials: E
authors.lastname: Nagy
authors.affiliation: Laboratory of Molecular Pathology, Department of Pathology and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, 77900 Olomouc, Czech Republic.
authors.forename: Patrik
authors.initials: P
authors.lastname: Flodr
authors.affiliation: Department of Oral Biology and Biomedical Sciences & Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Lee-Fah
authors.initials: LF
authors.lastname: Yap
authors.affiliation: University of Groningen and University Medical Centre Groningen Department of Pathology and Medical Biology, Groningen, The Netherlands.
authors.forename: Arjan
authors.initials: A
authors.lastname: Diepstra
authors.affiliation: University of Groningen and University Medical Centre Groningen Department of Pathology and Medical Biology, Groningen, The Netherlands.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Kluin
authors.affiliation: University of Groningen and University Medical Centre Groningen Department of Pathology and Medical Biology, Groningen, The Netherlands.
authors.forename: Stefano
authors.initials: S
authors.lastname: Rosati
authors.affiliation: Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Murray
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology*; D002454:Cell Differentiation / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000821:virology; D005260:Female; D018858:Germinal Center / Q000276:immunology* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000821:virology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D014763:Viral Matrix Proteins; D014779:Virus Replication / Q000276:immunology; D055815:Young Adult
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D011947:Receptors, Antigen, B-Cell; D014763:Viral Matrix Proteins