title: The Syndrome of Inappropriate Secretion of AntiDiuretic Hormone in Patients With Brucellosis.
abstract: OBJECTIVE
  Various studies have shown that a number of infectious disease causes syndrome of inappropriate antidiuretic hormone (SIADH). However, the relationship between infectious disease and SIADH is not yet fully known. In this prospective study, we aimed to assess the presence of SIADH in patients with brucellosis.
  
  
  METHODS
  Thirty-five patients with acute brucellosis were retrospectively reviewed. The diagnosis of brucellosis was performed using the Wright test in connection with blood culture. SIADH was defined by euvolemic hyponatremia (serum sodium level lower than 135 mEq/l) with increased urinary sodium excretion (urinary sodium higher than 40 mmol/l).
  
  
  RESULTS
  Of the 35 patients, 19 (54%) had SIADH; 20 (57%) also had hypouricemia (uric acid level lower than 4 mg/dl). Additionally, all of the studied patients had a high mean urinary sodium excretion rate (mean 132 mmol/l; range 40-224). Most importantly, the hyponatremic patients were more likely to have a lower albumin level (P < 0.01).
  
  
  CONCLUSIONS
  SIADH is a major complication of brucellosis. The presence of SIADH could be a diagnostic tool for diagnosing brucellosis. Further larger randomized studies may confirm these findings.
authors.affiliation: Department of Gastroenterology, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
authors.forename: Ahmet Cumhur
authors.initials: AC
authors.lastname: Dulger
authors.affiliation: Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.affiliation: Department of Infectious Disease and Clinical Microbiology, Medical Faculty, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Mehmet Resat
authors.initials: MR
authors.lastname: Ceylan
authors.affiliation: Department of Gastroenterology, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
authors.forename: Sehmus
authors.initials: S
authors.lastname: Olmez
authors.affiliation: Department of Emergency Medicine, Medical Faculty, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Sevdegul
authors.initials: S
authors.lastname: Karadas
authors.affiliation: Department of Infectious Disease and Clinical Microbiology, Medical Faculty, Yuzuncu Yıl University, Van, Turkey.
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Akdeniz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002006:Brucellosis / Q000150:complications*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000503:physiopathology; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012964:Sodium / Q000097:blood / Q000652:urine; D055815:Young Adult
chemical_list: D012964:Sodium
keywords: SIADH; brucellosis; hyponatremia; urinary sodium