title: Genistein prevents cadmium-induced neurotoxic effects through its antioxidant mechanisms.
abstract: BACKGROUND
  Cadmium-induced neurotoxic effects are mediated through adverse oxidative stress and calcium signaling. Genistein, a phytoestrogen is a potent antioxidant and exhibits property to cross blood-brain barrier.
  
  
  METHODS
  Experimental model of cadmium-induced neurotoxic effects were induced by treatment with cadmium (5 mg/kg) for 28 days in wistar rats. For determining the protective effect, genistein was administered at a dose of (10 mg/kg) for 7 days followed by cadmium treatment for 28 days. Serum and tissues were analyzed for various oxidative stress markers such as total antioxidant capacity, total oxidant levels, non-enzymic antioxidants, enzymic antioxidants, lipid peroxide levels and protein carbonyl content.
  
  
  RESULTS
  The results showed significant increase in the oxidative stress markers during cadmium treatment was attenuated in rats treated with genistein followed by cadmium treatment. In addition, cadmium induced alterations and activities of ATPase were significantly restored by genistein treatment.
  
  
  CONCLUSIONS
  The present study observations show promising results of genistein against cadmium-induced neurotoxic effects in wistar rats. Thus its potent antioxidant and cytoprotective effects could act as potent therapeutic agent against various neuro-degenerative diseases involving oxidative stress as primary mechanism.
authors.affiliation: Department of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei Province, China.
authors.forename: D-k
authors.initials: DK
authors.lastname: Gong
authors.affiliation: Department of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei Province, China.
authors.forename: B-h
authors.initials: BH
authors.lastname: Liu
authors.affiliation: Department of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei Province, China.
authors.forename: X-h
authors.initials: XH
authors.lastname: Tan
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D019256:Cadmium Chloride / Q000633:toxicity*; D019833:Genistein / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats
chemical_list: D000975:Antioxidants; D019833:Genistein; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D019256:Cadmium Chloride