title: Relationship between elevated morning blood pressure surge, uric acid, and cardiovascular outcomes in hypertensive patients.
abstract: Early morning blood pressure surge (MBPS) is a risk factor for cardiovascular events (CVEs), but the relationship with uric acid is not well understood. The authors aimed to determine the association between MBPS and increased uric acid and the effect of elevated MBPS and uric acid combination on CVEs. A total of 921 patients underwent 24-hour ambulatory blood pressure monitoring and were followed for a median of 40 months. During this period, 103 (11.2%) CVEs occurred. There was a significant relationship between increasing quartiles of serum uric acid level and increasing values of MBPS (P<.0001). Patients in the highest quartile stratified by elevated MBPS and serum uric acid level had a 3.55 odds of major CVE compared with patients in the lowest quartile. Serum uric acid is associated with MBPS and development of new CVEs.
authors.affiliation: Department of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.forename: Firat
authors.initials: F
authors.lastname: Ozcan
authors.forename: Ugur
authors.initials: U
authors.lastname: Canpolat
authors.forename: Enis
authors.initials: E
authors.lastname: Grbovic
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Mendi
authors.forename: Fatih
authors.initials: F
authors.lastname: Oksuz
authors.forename: Dimitrie
authors.initials: D
authors.lastname: Siriopol
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.forename: Mustafa
authors.initials: M
authors.lastname: Caliskan
authors.forename: Kim
authors.initials: K
authors.lastname: McFann
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002319:Cardiovascular System / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid