title: Physiological parameters of Macaca fascicularis immunized with anti-rubella vaccine with germanium-based adjuvants.
abstract: Clinical status, hematological and biochemical parameters, and allergenic activity of organogermanium compounds used as adjuvants in complex with preparation from Orlov rubella virus vaccine strain and reference commercial anti-rubella vaccine based on Wistar RA 27/3 strain were studied on Macaca fascilcularis of both genders. Physiological parameters of monkeys immunized with the Russian and foreign rubella virus vaccine strains with and without adjuvants did not differ. The adjuvants were inessential for the safety of vaccines (absence of toxicity, reactogenic activity, or allergenic activity) in preclinical studies on lower primates.
authors.affiliation: Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi-Adler, Russia, Karal_5@mail.ru.
authors.forename: D D
authors.initials: DD
authors.lastname: Karal-Ogly
authors.forename: V Z
authors.initials: VZ
authors.lastname: Agrba
authors.forename: I N
authors.initials: IN
authors.lastname: Lavrent'eva
authors.forename: I V
authors.initials: IV
authors.lastname: Ambrosov
authors.forename: S K
authors.initials: SK
authors.lastname: Matelo
authors.forename: Yu P
authors.initials: YP
authors.lastname: Chuguev
authors.forename: I A
authors.initials: IA
authors.lastname: Gvaramiya
authors.forename: T E
authors.initials: TE
authors.lastname: Gvozdik
authors.forename: E I
authors.initials: EI
authors.lastname: Mukhametzyanova
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000737:chemistry*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001772:Blood Cell Count; D004353:Drug Evaluation, Preclinical; D005260:Female; D005857:Germanium / Q000737:chemistry / Q000276:immunology; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D051381:Rats; D012409:Rubella / Q000097:blood / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D012411:Rubella Vaccine / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology*; D014613:Vaccines, Attenuated
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D009942:Organometallic Compounds; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated; D005857:Germanium; D007073:Immunoglobulin E