title: Yin-Yang strands of PCAF/Hedgehog axis in cancer control.
abstract: PCAF (p300/CBP associated factor) harbors acetyltransferase and a recently identified ubiquitylation activity that regulates gene expression in response to genotoxic stress or mitogenic signals. We highlight the dual role of PCAF in the control of Hedgehog signaling, a master regulator of tissue development, stemness, and tumorigenesis. By promoting histone acetylation at Hedgehog/GLI1 target gene promoters or direct ubiquitylation and proteolysis of GLI1, the PCAF/GLI1 axis stands as a promising therapeutic target for Hedgehog-dependent tumors.
authors.affiliation: Center for Life Nanoscience (CLNS), Italian Institute of Technology-Sapienza, 00161 Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Infante
authors.affiliation: Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Canettieri
authors.affiliation: Center for Life Nanoscience (CLNS), Italian Institute of Technology-Sapienza, 00161 Rome, Italy; Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy; IRCCS Neuromed, 86077 Pozzilli, Italy. Electronic address: alberto.gulino@uniroma1.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gulino
authors.affiliation: Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy. Electronic address: lucia.dimarcotullio@uniroma1.it.
authors.forename: Lucia
authors.initials: L
authors.lastname: Di Marcotullio
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D055808:Drug Discovery; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D054875:Ubiquitination; D050880:p300-CBP Transcription Factors / Q000378:metabolism*; D000099224:p300-CBP-Associated Factor
chemical_list: D000123:Acetyltransferases; D053823:Hedgehog Proteins; D016159:Tumor Suppressor Protein p53; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
keywords: E3-ubiquitin ligase; Hedgehog; PCAF; acetyltransferase; cancer; p53