title: Pristinamycin: old drug, new tricks?
abstract: Osteoarticular infections with Gram positive bacteria present an increasing challenge in an era of multidrug-resistant organisms. Prolonged intravenous antibiotic treatment is often required, with associated risks, costs and difficulties with administration; a safe, effective oral option would be ideal for this indication. Pristinamycin, an oral streptogramin antibiotic with bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus, has been used for over 50 years in Europe for the treatment of osteoarticular infections. We review the published evidence for the treatment of native bone and prosthesis-related osteoarticular infections with pristinamycin.
authors.affiliation: Department of Paediatrics, University of Melbourne, Victoria, Australia Infectious Diseases and Clinical Pharmacology Unit, Department of Medicine, The Royal Children's Hospital Melbourne, Victoria, Australia eden.cooper@rch.org.au.
authors.forename: Eden C
authors.initials: EC
authors.lastname: Cooper
authors.affiliation: Department of Paediatrics, University of Melbourne, Victoria, Australia Infectious Diseases and Clinical Pharmacology Unit, Department of Medicine, The Royal Children's Hospital Melbourne, Victoria, Australia Murdoch Childrens Research Institute, Victoria, Australia.
authors.forename: Nigel
authors.initials: N
authors.lastname: Curtis
authors.affiliation: Department of Paediatrics, University of Melbourne, Victoria, Australia Infectious Diseases and Clinical Pharmacology Unit, Department of Medicine, The Royal Children's Hospital Melbourne, Victoria, Australia Murdoch Childrens Research Institute, Victoria, Australia.
authors.forename: Noel
authors.initials: N
authors.lastname: Cranswick
authors.affiliation: Infectious Diseases and Clinical Pharmacology Unit, Department of Medicine, The Royal Children's Hospital Melbourne, Victoria, Australia Murdoch Childrens Research Institute, Victoria, Australia.
authors.forename: Amanda
authors.initials: A
authors.lastname: Gwee
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy*; D025762:Pristinamycin / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D025762:Pristinamycin
keywords: Gram positive infections; arthritis; bone and joint infections; osteomyelitis; prosthesis infections; quinupristin/dalfopristin; streptogramin