title: Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.
abstract: Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.
authors.affiliation: Dipartimento di Farmacia, via D. Montesano 49, 80131 Napoli, Italy. varra@unina.it cfattoru@unina.it.
authors.forename: M
authors.initials: M
authors.lastname: Scuotto
authors.forename: M
authors.initials: M
authors.lastname: Persico
authors.forename: M
authors.initials: M
authors.lastname: Bucci
authors.forename: V
authors.initials: V
authors.lastname: Vellecco
authors.forename: N
authors.initials: N
authors.lastname: Borbone
authors.forename: E
authors.initials: E
authors.lastname: Morelli
authors.forename: G
authors.initials: G
authors.lastname: Oliviero
authors.forename: E
authors.initials: E
authors.lastname: Novellino
authors.forename: G
authors.initials: G
authors.lastname: Piccialli
authors.forename: G
authors.initials: G
authors.lastname: Cirino
authors.forename: M
authors.initials: M
authors.lastname: Varra
authors.forename: C
authors.initials: C
authors.lastname: Fattorusso
authors.forename: L
authors.initials: L
authors.lastname: Mayol
mesh_terms: D000991:Antithrombins / Q000138:chemical synthesis* / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D054856:G-Quadruplexes; D008958:Models, Molecular; D018716:Molecular Mimicry; D009705:Nucleosides / Q000737:chemistry*; D009904:Optical Rotation; D013237:Stereoisomerism; D013816:Thermodynamics; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D000991:Antithrombins; D052157:Aptamers, Nucleotide; D009705:Nucleosides; C081676:thrombin aptamer; D013917:Thrombin