title: Study of MET protein levels and MET gene copy number in 72 sinonasal intestinal-type adenocarcinomas.
abstract: BACKGROUND
  Sinonasal intestinal-type adenocarcinomas (ITACs) have a poor prognosis, and are defined on the basis of their morphological similarities to colorectal adenocarcinomas. MET signaling pathway is involved in oncogenesis in various cancers. Nothing is currently known about the role of MET in ITACs.
  
  
  METHODS
  In a series of 72 ITACs, we investigated MET protein levels by immunohistochemistry (IHC) and gene copy number by in situ hybridization. These findings were analyzed as a function of clinical data, histological typing, and patient outcome.
  
  
  RESULTS
  MET protein was overproduced in 64% of cases and chromosome 7 polysomy was observed in 52% of cases. No tumor displayed MET amplification. The presence of mucinous or solid histological components, T3/T4 tumors, and incomplete resection were associated with a poor outcome.
  
  
  CONCLUSIONS
  MET is overproduced in about two third of ITACs, suggesting a role for the MET signaling pathway in the oncogenesis of these tumors.
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Projetti
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Mesturoux
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: Béma
authors.initials: B
authors.lastname: Coulibaly
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Durand
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Chaunavel
authors.affiliation: Department of Medical Oncology, Dupuytren University Hospital, Limoges, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Léobon
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Gadeaud
authors.affiliation: Department of Neurosurgery, Dupuytren University Hospital, Limoges, France.
authors.forename: François
authors.initials: F
authors.lastname: Caire
authors.affiliation: Department of Head and Neck Surgery, Dupuytren University Hospital, Limoges, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bessède
authors.affiliation: Department of Pathology, Dupuytren University Hospital, Limoges, France.
authors.forename: François
authors.initials: F
authors.lastname: Labrousse
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization; D007414:Intestinal Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D015398:Signal Transduction; D018709:Statistics, Nonparametric; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: MET; amplification; c-MET; epidermal growth factor receptor (EGFR); immunohistochemistry; sinonasal intestinal-type adenocarcinoma (ITAC)