title: Lipidated peptidomimetics with improved antimicrobial activity.
abstract: We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Yaogang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Mohamad Nassir
authors.initials: MN
authors.lastname: Amin
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Shruti
authors.initials: S
authors.lastname: Padhee
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Rongsheng E
authors.initials: RE
authors.lastname: Wang
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Qiao
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Ge
authors.initials: G
authors.lastname: Bai
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Yaqong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Archana
authors.initials: A
authors.lastname: Mathew
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
keywords: antimicrobial peptides; drug resistance; lipidation; peptidomimetics; α-AApeptides