title: Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack.
abstract: BACKGROUND
  The purpose of this study was to elucidate the incidence and predictors of ischemic stroke or recurrent transient ischemic attack (TIA) during acute hospitalization in patients with TIA.
  
  
  METHODS
  We carried out a multicenter retrospective study to clarify the characteristics of in-patients with TIA. The subjects of this study were TIA patients admitted to 13 stroke hospitals within 7 days after onset between 2008 and 2009. TIA was defined as focal neurologic symptoms ascribable to a vascular etiology lasting less than 24 h. We investigated the incidence and predictors of ischemic events including ischemic stroke or recurrent TIA during hospitalization.
  
  
  RESULTS
  A total of 464 patients with TIA (292 men, 69 ± 13 years) were registered. Of those, 400 (86.2%) were admitted within 24 h of TIA onset. The mean length of hospital stay was 13 days. During hospitalization, 8 patients had ischemic strokes and 26 had recurrent TIAs. The leading subtype of 8 ischemic strokes was small vessel disease (n = 3) followed by cardioembolism (n = 2). Multiple logistic regression analysis showed that hypertension (OR: 3.41; 95% CI: 1.23-12.3), MRI-diffusion-weighted image positivity (OR: 2.49; 95% CI: 1.15-5.25), and hemiparesis (OR: 2.30; 95% CI: 1.02-5.88) were independently associated with ischemic events during hospitalization.
  
  
  CONCLUSIONS
  In this study, 1.7% of patients with TIA had ischemic stroke during acute hospitalization, and the most common subtype was small vessel disease. Subsequent ischemic stroke and recurrent TIA were associated with hypertension, positive DWI findings, and hemiparesis.
authors.affiliation: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Fujinami
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Uehara
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
authors.forename: Akifumi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Takagi
authors.forename: Jyoji
authors.initials: J
authors.lastname: Nakagawara
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Arii
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Takehiko
authors.initials: T
authors.lastname: Nagao
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Masayasu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Koji
authors.initials: K
authors.lastname: Iihara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Minematsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D002546:Ischemic Attack, Transient / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*