title: Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674.
abstract: Genome sequencing identified a fluorinase gene in the marine bacterium Streptomyces xinghaiensis NRRL B-24674. Fermentation of the organism with inorganic fluoride (2 mM) demonstrated that the organism could biosynthesise fluoroacetate and that fluoroacetate production is sea-salt dependent. This is the first fluorometabolite producing microorganism identified from the marine environment.
authors.affiliation: Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P. R. China. yuyi119@hotmail.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Huang
authors.forename: Long
authors.initials: L
authors.lastname: Ma
authors.forename: Ming Him
authors.initials: MH
authors.lastname: Tong
authors.forename: Yi
authors.initials: Y
authors.lastname: Yu
authors.forename: David
authors.initials: D
authors.lastname: O'Hagan
authors.forename: Hai
authors.initials: H
authors.lastname: Deng
mesh_terms: D005463:Fluoroacetates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*; D013912:Threonine / Q000031:analogs & derivatives / Q000378:metabolism; D014153:Transaldolase / Q000235:genetics; D014871:Water Microbiology
chemical_list: D005463:Fluoroacetates; C048271:4-fluorothreonine; D013912:Threonine; D014153:Transaldolase