title: Establishing reliable miRNA-cancer association network based on text-mining method.
abstract: Associating microRNAs (miRNAs) with cancers is an important step of understanding the mechanisms of cancer pathogenesis and finding novel biomarkers for cancer therapies. In this study, we constructed a miRNA-cancer association network (miCancerna) based on more than 1,000 miRNA-cancer associations detected from millions of abstracts with the text-mining method, including 226 miRNA families and 20 common cancers. We further prioritized cancer-related miRNAs at the network level with the random-walk algorithm, achieving a relatively higher performance than previous miRNA disease networks. Finally, we examined the top 5 candidate miRNAs for each kind of cancer and found that 71% of them are confirmed experimentally. miCancerna would be an alternative resource for the cancer-related miRNA identification.
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China ; Biomedical Engineering Department, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
authors.forename: Lun
authors.identifier: 0000-0001-6757-7152
authors.initials: L
authors.lastname: Li
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China ; Biomedical Engineering Department, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
authors.forename: Xingchi
authors.identifier: 0000-0003-3979-1957
authors.initials: X
authors.lastname: Hu
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China ; Biomedical Engineering Department, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
authors.forename: Zhaowan
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Statistics, The University of Akron, Akron, OH 44325, USA ; Department of Family & Community Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA ; Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang 550018, China.
authors.forename: Zhenyu
authors.identifier: 0000-0002-1428-904X
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China ; Biomedical Engineering Department, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China ; Biomedical Engineering Department, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China ; Biomedical Engineering Department, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining / Q000379:methods*; D005189:False Positive Reactions; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D011336:Probability; D015203:Reproducibility of Results
chemical_list: D035683:MicroRNAs