title: Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.
abstract: We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks. In alcohol-preferring animals (mean daily ethanol intake >5.0 g/kg) allowed free choice between 10 % ethanol and water, single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption. The fi ndings suggest that selank is effective in eliminating of alcohol withdrawal symptoms in rats.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, lgkolik@mail.ru.
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
authors.forename: A V
authors.initials: AV
authors.lastname: Nadorova
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaya
mesh_terms: D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D021461:Animals, Outbred Strains; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000503:physiopathology / Q000517:prevention & control*; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage; D006930:Hyperalgesia / Q000503:physiopathology / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D000431:Ethanol; C100827:TP 7