title: Vaccination of domestic animals against tuberculosis: review of progress and contributions to the field of the TBSTEP project.
abstract: Tuberculosis either caused by Mycobacterium bovis or M. caprae is a significant burden to agricultural industries worldwide. Vaccination of domestic ruminant species such as cattle and goats constitutes a potential tool to support disease control. This review will discuss recent progress made to develop tuberculosis vaccines against domestic ruminants as well as approaches to differentiate vaccinated and infected animals (DIVA) and biomarker discovery studies.
authors.affiliation: Animal Health and Veterinary Laboratories Agency - Wyebridge, Addlestone, Surrey, UK. Electronic address: martin.vordermeier@ahvla.gsi.gov.uk.
authors.forename: H Martin
authors.initials: HM
authors.lastname: Vordermeier
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, Edifici CReSA, Bellaterra, 08193 Catalonia, Spain.
authors.forename: Bernat
authors.initials: B
authors.lastname: Pérez de Val
authors.affiliation: AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand.
authors.forename: Bryce M
authors.initials: BM
authors.lastname: Buddle
authors.affiliation: Animal Health and Veterinary Laboratories Agency - Wyebridge, Addlestone, Surrey, UK.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Villarreal-Ramos
authors.affiliation: Animal Health and Veterinary Laboratories Agency - Wyebridge, Addlestone, Surrey, UK.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Jones
authors.affiliation: Animal Health and Veterinary Laboratories Agency - Wyebridge, Addlestone, Surrey, UK.
authors.forename: R Glyn
authors.initials: RG
authors.lastname: Hewinson
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, Edifici CReSA, Bellaterra, 08193 Catalonia, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Domingo
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D001500:BCG Vaccine / Q000276:immunology / Q000627:therapeutic use; D002417:Cattle; D003937:Diagnosis, Differential; D005060:Europe; D015511:Goat Diseases / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D006041:Goats; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012418:Ruminants; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D032581:Tuberculosis Vaccines / Q000276:immunology / Q000627:therapeutic use*; D014380:Tuberculosis, Bovine / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000639:trends / Q000662:veterinary*
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines
keywords: Biomarkers; Cattle; DIVA; Goats; Tuberculosis; Vaccination