title: Investigation of mechanical strength of teicoplanin and ciprofloxacin impregnated bone cement on Day 1 and Day 15.
abstract: OBJECTIVE
  The aim of this study was to compare the mechanical effects of different concentrations of teicoplanin and ciprofloxacin addition in bone cement.
  
  
  METHODS
  In an experimental design, 3 different doses of teicoplanin and ciprofloxacin (800, 1600 and 3200 mg) were added to bone cement. Mechanical tests using compression and four-point bending tests were performed on Day 1 and after antibiotic leaching in water at 37°C on Day 15. Specimens that contained no antibiotics served as controls. Mechanical strength for each antibiotic concentration on Day 1 and Day 15 were evaluated.
  
  
  RESULTS
  Both teicoplanin and ciprofloxacin significantly decreased the mean strength values in compression and four-point bending tests at Days 1 and 15 (p<0.05). While teicoplanin significantly decreased the mean strength values at high doses in both tests at Days 1 and 15 (p<0.05), ciprofloxacin did not significantly change these values. When the effects of two drugs compared, there were significant differences at the 3200 mg dose at Day 1 and at 1600 and 3200 mg doses at Day 15 in the compression testing and at 3200 mg at Day 15 in the four-point bending test.
  
  
  CONCLUSIONS
  Teicoplanin and ciprofloxacin addition may adversely affect the biomechanical strength of bone cement. Ciprofloxacin addition seems to have less of a negative effect on strength than teicoplanin.
authors.affiliation: Department of Orthopedics and Traumatology, Çanakkale Onsekiz Mart University, Faculty of Medicine, Çanakkale, Turkey. uhg31@hotmail.com.
authors.forename: Umut Hatay
authors.initials: UH
authors.lastname: Gölge
authors.affiliation: Department of Orthopedics and Traumatology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey.
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Oztemur
authors.affiliation: Department of Pharmacology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Parlak
authors.affiliation: Department of Orthopedics and Traumatology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey.
authors.forename: Gündüz
authors.initials: G
authors.lastname: Tezeren
authors.affiliation: Department of Orthopedics and Traumatology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey.
authors.forename: Hayati
authors.initials: H
authors.lastname: Oztürk
authors.affiliation: Department of Orthopedics and Traumatology, Cumhuriyet University, Faculty of Medicine, Sivas, Turkey.
authors.forename: Okay
authors.initials: O
authors.lastname: Bulut
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D002939:Ciprofloxacin / Q000008:administration & dosage*; D019245:Compressive Strength; D006801:Humans; D008422:Materials Testing / Q000379:methods / Q000592:standards; D013314:Stress, Mechanical; D017334:Teicoplanin / Q000008:administration & dosage*; D013718:Tensile Strength
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002939:Ciprofloxacin; D017334:Teicoplanin