title: Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Alice C
authors.initials: AC
authors.lastname: Eziefula
authors.affiliation: Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Helmi
authors.initials: H
authors.lastname: Pett
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Lynn
authors.initials: L
authors.lastname: Grignard
authors.affiliation: Infectious Diseases Research Collaboration, Kampala, Uganda.
authors.forename: Salome
authors.initials: S
authors.lastname: Opus
authors.affiliation: Infectious Diseases Research Collaboration, Kampala, Uganda.
authors.forename: Moses
authors.initials: M
authors.lastname: Kiggundu
authors.affiliation: Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
authors.forename: Moses R
authors.initials: MR
authors.lastname: Kamya
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Shunmay
authors.initials: S
authors.lastname: Yeung
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Sarah G
authors.initials: SG
authors.lastname: Staedke
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Teun
authors.initials: T
authors.lastname: Bousema
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom teun.bousema@lshtm.ac.uk.
authors.forename: Chris
authors.initials: C
authors.lastname: Drakeley
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006454:Hemoglobins / Q000378:metabolism*; D006461:Hemolysis; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects / Q000502:physiology; D011319:Primaquine / Q000627:therapeutic use*; D012306:Risk; D014454:Uganda
chemical_list: D000962:Antimalarials; D006454:Hemoglobins; D005954:Glucosephosphate Dehydrogenase; C482910:glucose-6-phosphate dehydrogenase A-; D011319:Primaquine