title: Thyrotropin in the development and management of differentiated thyroid cancer.
abstract: Thyrotropin (TSH) is the major regulator and growth factor of the thyroid. TSH may be important in the development of human thyroid cancer, with both suggestive animal models and clinical evidence, although definitive proof is still required. Applications for TSH in thyroid cancer management include TSH stimulation of radioiodine uptake, enhancement of biochemical monitoring through thyroglobulin measurement, and long-term suppression of TSH with supraphysiologic levothyroxine. This review synthesizes current knowledge of TSH in both the development and management of differentiated thyroid cancer.
authors.affiliation: Department of Internal Medicine & Aged Care, Royal Brisbane & Women's Hospital, Level 3, Dr James Mayne Building, Herston, Queensland 4029, Australia; Department of Endocrinology, Royal Brisbane & Women's Hospital, Level 1, Dr James Mayne Building, Herston, Queensland 4029, Australia; Department of Population Health, QIMR Berghofer Medical Research Institute, Herston Road, Herston, Queensland 4029, Australia. Electronic address: donald.mcleod@qimrberghofer.edu.au.
authors.forename: Donald S A
authors.initials: DS
authors.lastname: McLeod
mesh_terms: D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D013972:Thyrotropin / Q000097:blood*
chemical_list: D007457:Iodine Radioisotopes; D013972:Thyrotropin
keywords: Recombinant human TSH; TSH; Thyroid cancer; Thyroid hormone; Thyrotropin