title: Genetic variations in IL1A and IL1RN are associated with the risk of preeclampsia in Chinese Han population.
abstract: Preeclampsia (PE) is an excessive systemic inflammation response with dysfunction of endothelial. Our study was to investigate the association between genetic variations in IL-1 and the susceptibility to PE in Chinese Han population. 402 PE patients and 554 normal pregnant women of third trimester were enrolled. The polymorphisms of rs315952 in IL1RN and rs17561 in IL1A were genotyped by TaqMan allelic discrimination real-time PCR. Obviously statistic difference of the genotypic frequencies were found in both of IL1RN rs315952 and IL1A rs17561 between cases and controls (for rs315952, P = 0.001; for rs17561, P = 0.021.). For rs315952, the C allele was associated with development of PE (P = 0.003, OR = 1.319, 95%CI 1.099-1.583). Patients with CC or CT genotype were less likely to develop severe PE than patients carrying TT genotype(P < 0.001, OR = 0.24, 95%CI 0.15-0.40). For rs17561, the C allele was the risk factor for predisposition to PE (P = 0.012, OR = 1.496, 95%CI 1.089-2.055). Our results suggest IL1RN and IL1A may involve in the development of PE in Chinese Han population.
authors.affiliation: 1] Department of clinical laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China [2].
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: 1] Nephrology department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China [2].
authors.forename: Mengchun
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of clinical laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Jinbao
authors.initials: J
authors.lastname: Zong
authors.affiliation: Obstetrical department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Tan
authors.affiliation: Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wang
authors.affiliation: Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Xunfeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Obstetrical department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Ye
authors.affiliation: 1] Obstetrical department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China [2] Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Nephrology department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012306:Risk; D012307:Risk Factors
chemical_list: C508584:IL1A protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha