title: Resting-state brain activation correlates with short-time antidepressant treatment outcome in drug-naïve patients with major depressive disorder.
abstract: OBJECTIVE
  A resting-state functional magnetic resonance imaging study (fMRI) to investigate pretreatment regional differences in brain function, in patients with early treatment responsive (ERD) and early treatment nonresponsive (END) major depressive disorder (MDD).
  
  
  METHODS
  Patients with MDD and healthy control subjects underwent fMRI. Intrinsic neural activity at baseline was evaluated via amplitude of low-frequency fluctuations (ALFF). Antidepressant treatment was initiated after MRI. All patients received selective serotonin reuptake inhibitor type antidepressants at the minimum effective dose.
  
  
  RESULTS
  There were significant differences in brain activity between patients (n = 56) and control subjects (n = 33). Brain activity in patients with ERD (n = 26) differed from those with END (n = 30) in the lingual gyrus and cerebellum. There was a significantly correlation between activity in these regions and disease duration in patients with ERD, and with amelioration of depressive symptoms in patients with END.
  
  
  CONCLUSIONS
  Brain regions related to the neural mechanism of MDD early treatment outcome were identified. These regions may have important implications for the treatment of MDD.
authors.affiliation: Huaxi Mental Health Centre, Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Huaxi Mental Health Centre, Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Kuang
authors.affiliation: Huaxi Mental Health Centre, Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Du
authors.initials: D
authors.lastname: Lei
authors.affiliation: Huaxi Mental Health Centre, Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University, Chengdu, China yanchun.yang2014@163.com.
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Yang
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002531:Cerebellum / Q000502:physiology*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D009778:Occipital Lobe / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Major depressive disorder; amplitude of low-frequency fluctuations; functional magnetic resonance imaging; treatment outcome