title: Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators.
abstract: Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)2Cbi.
authors.affiliation: Institute of Organic Chemistry PAS , Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Keith Ó
authors.initials: KÓ
authors.lastname: Proinsias
authors.affiliation: Institute of Organic Chemistry PAS , Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Giedyk
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Health Science Center in Houston, 1941 East Road, The University of Texas , Houston, Texas 77054, United States.
authors.forename: Iraida G
authors.initials: IG
authors.lastname: Sharina
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Health Science Center in Houston, 1941 East Road, The University of Texas , Houston, Texas 77054, United States.
authors.forename: Emil
authors.initials: E
authors.lastname: Martin
authors.affiliation: Institute of Organic Chemistry PAS , Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Gryko
keywords: aminolysis; cobinamide; soluble guanyl cyclase; vitamin B12