title: Applying "gold standards" to in-vitro-derived germ cells.
abstract: Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA. Electronic address: maryann.handel@jax.org.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Handel
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Eppig
authors.affiliation: Cornell University, Ithaca, NY 14853, USA. Electronic address: jcs92@cornell.edu.
authors.forename: John C
authors.initials: JC
authors.lastname: Schimenti
mesh_terms: D003584:Cytological Techniques / Q000592:standards*; D005260:Female; D005718:Gametogenesis; D005854:Germ Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D008540:Meiosis; D013234:Stem Cells / Q000166:cytology*