title: Self-propelled polymer multilayer Janus capsules for effective drug delivery and light-triggered release.
abstract: We present herein a novel hybrid, polymer-based motor that was fabricated by the template-assisted polyelectrolyte layer-by-layer (LbL) deposition of a thin gold layer on one side, followed by chemical immobilization of a catalytic enzyme. Such Janus capsule motors can self-propel at 0.1% peroxide fuel concentration at physiological temperature and have a higher speed as compared to Pt-based synthetic motors. They were exploited for encapsulation of the chemotherapeutic anticancer drug, doxorubicin, for navigation to target a cell layer by an external magnetic field, and for triggered drug release activated by NIR light. This work provides high potential in the development of multifunctional polymer-based engines for biomedical applications such as targeted drug delivery.
authors.affiliation: State Key Lab of Urban Water Resource and Environment (HIT), Micro/Nanotechnology Research Centre, Harbin Institute of Technology , Harbin 150080, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiankun
authors.initials: X
authors.lastname: Lin
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Wu
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D002214:Capsules; D016503:Drug Delivery Systems; D008027:Light; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*
chemical_list: D002214:Capsules; D011108:Polymers