title: Modeling acclimatization by hybrid systems: condition changes alter biological system behavior models.
abstract: In order to describe the dynamic behavior of a complex biological system, it is useful to combine models integrating processes at different levels and with temporal dependencies. Such combinations are necessary for modeling acclimatization, a phenomenon where changes in environmental conditions can induce drastic changes in the behavior of a biological system. In this article we formalize the use of hybrid systems as a tool to model this kind of biological behavior. A modeling scheme called strong switches is proposed. It allows one to take into account both minor adjustments to the coefficients of a continuous model, and, more interestingly, large-scale changes to the structure of the model. We illustrate the proposed methodology with two applications: acclimatization in wine fermentation kinetics, and acclimatization of osteo-adipo differentiation system linking stimulus signals to bone mass.
authors.affiliation: ICBM Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile; Centro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas and Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile. Electronic address: rodrigo.assar@gmail.com.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Assar
authors.affiliation: Centro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas and Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile; FONDAP 15090007 Center for Genome Regulation, Santiago, Chile. Electronic address: mmontecino@unab.cl.
authors.forename: Martín A
authors.initials: MA
authors.lastname: Montecino
authors.affiliation: Departamento de Ingeniería Matemática y Centro de Modelamiento Matemático, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile; FONDAP 15090007 Center for Genome Regulation, Santiago, Chile. Electronic address: amaass@dim.uchile.cl.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Maass
authors.affiliation: INRIA Bordeaux Sud-Ouest, Project-team (EPC) MAGNOME common to INRIA, CNRS, and U. Bordeaux 1, Talence, France. Electronic address: david.sherman@inria.fr.
authors.forename: David J
authors.initials: DJ
authors.lastname: Sherman
mesh_terms: D000064:Acclimatization / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001842:Bone and Bones / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D004777:Environment; D005285:Fermentation / Q000502:physiology; D006801:Humans; D006824:Hybridization, Genetic / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological; D014920:Wine
keywords: Acclimatization; Hybrid systems