title: Nuclear positioning by actin cables and perinuclear actin: Special and general?
abstract: Nuclear positioning is an important process during development and homeostasis. Depending on the affected tissue, mislocalized nuclei can alter cellular processes such as polarization, differentiation, or migration and lead ultimately to diseases. Many cells actively control the position of their nucleus using their cytoskeleton and motor proteins. We have recently shown that during Drosophila oogenesis, nurse cells employ cytoplasmic actin cables in association with perinuclear actin to position their nucleus. Here, we briefly summarize our work and discuss why nuclear positioning in nurse cells is specialized but the molecular mechanisms are likely to be more generally used.
authors.affiliation: The Gurdon Institute and Department of Physiology, Development, and Neuroscience; University of Cambridge; Cambridge, UK; Department of Biological and Environmental Science; University of Jyväskylä; Jyväskylä, Finland.
authors.forename: Sven
authors.initials: S
authors.lastname: Huelsmann
authors.affiliation: The Gurdon Institute and Department of Physiology, Development, and Neuroscience; University of Cambridge; Cambridge, UK.
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Brown
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans
chemical_list: D000199:Actins
keywords: Drosophila; LINC complex; actin cables; dumping; filamin; nuclear positioning; nurse cells; perinuclear actin