title: CT-guided radiofrequency tumor ablation in children.
abstract: BACKGROUND
  Image-guided radiofrequency ablation is a well-accepted technique of interventional oncology in adults.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of CT-guided radiofrequency ablation as a minimally invasive treatment for metastatic neoplasms in children.
  
  
  METHODS
  A total of 15 radiofrequency ablation sessions were performed in 12 children and young adults (median age 9.5; range 5-18 years) with metastatic malignancies. Seven children and young adults had secondary hepatic lesions, three had pulmonary and two had bone lesions. Radiofrequency ablation was performed under conscious sedation.
  
  
  RESULTS
  The median lesion size was 1.7 cm (range 1.3-2.8 cm). The median time for ablation was 8 min (range 7-10 min). Radiofrequency procedures were technically successful in all tumors. Postablation imaging immediately after, and 1 month and 3 months after radiofrequency ablation showed total necrosis in all patients. At 6-month follow-up, three patients (all with lesion size >2 cm) had local recurrence and underwent a second radiofrequency ablation session. At 2-year follow-up no patient had recurrence of the treated tumor. Post-ablation syndrome occurred in four children. No major complication occurred.
  
  
  CONCLUSIONS
  CT-guided radiofrequency tumor ablation was safe and efficient for palliative treatment in our cohort of patients.
authors.affiliation: First Pediatric Clinic, Agia Sofia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Evanthia
authors.initials: E
authors.lastname: Botsa
authors.forename: Loukia S
authors.initials: LS
authors.lastname: Poulou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Koutsogiannis
authors.forename: Panayiotis D
authors.initials: PD
authors.lastname: Ziakas
authors.forename: Antonia
authors.initials: A
authors.lastname: Koundouraki
authors.forename: Efthimia
authors.initials: E
authors.lastname: Alexopoulou
authors.forename: Loukas
authors.initials: L
authors.lastname: Thanos
mesh_terms: D000293:Adolescent; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging* / Q000628:therapy*; D010149:Postoperative Pain / Q000175:diagnosis / Q000209:etiology; D010166:Palliative Care / Q000379:methods*; D012189:Retrospective Studies; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome