title: Evaluation of different treatment methods against denture stomatitis: a randomized clinical study.
abstract: OBJECTIVE
  The aim of this clinical study was to determine the efficacy of Uncaria tomentosa (cat's claw) against denture stomatitis (DS).
  
  
  METHODS
  Fifty patients with DS were randomly assigned into 3 groups to receive 2% miconazole, placebo, or 2% U tomentosa gel. DS level was recorded immediately, after 1 week of treatment, and 1 week after treatment. The clinical effectiveness of each treatment was measured using Newton's criteria. Mycologic samples from palatal mucosa and prosthesis were obtained to determinate colony forming units per milliliter (CFU/mL) and fungal identification at each evaluation period.
  
  
  RESULTS
  Candida species were identified with HiCrome Candida and API 20C AUX biochemical test. DS severity decreased in all groups (P < .05). A significant reduction in number of CFU/mL after 1 week (P < .05) was observed for all groups and remained after 14 days (P > .05). C albicans was the most prevalent microorganism before treatment, followed by C tropicalis, C glabrata, and C krusei, regardless of the group and time evaluated. U tomentosa gel had the same effect as 2% miconazole gel.
  
  
  CONCLUSIONS
  U tomentosa gel is an effective topical adjuvant treatment for denture stomatitis.
authors.affiliation: Department of Dentistry, Ponta Grossa State University (UEPG), Ponta Grossa, Paraná, Brazil.
authors.forename: Lidia Yileng
authors.initials: LY
authors.lastname: Tay
authors.affiliation: Department of Dental Materials and Prosthodontics, Araraquara Dental School, UNESP - Univ. Estadual Paulista, Araraquara, São Paulo, Brazil. Electronic address: Janainahj@bol.com.br.
authors.forename: Janaina Habib
authors.initials: JH
authors.lastname: Jorge
authors.affiliation: Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
authors.forename: Daniel Rodrigo
authors.initials: DR
authors.lastname: Herrera
authors.affiliation: Department of Dentistry, Ponta Grossa State University (UEPG), Ponta Grossa, Paraná, Brazil.
authors.forename: Nara Hellen
authors.initials: NH
authors.lastname: Campanha
authors.affiliation: Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
authors.forename: Brenda Paula
authors.initials: BP
authors.lastname: Gomes
authors.affiliation: Department of Dentistry, Ponta Grossa State University (UEPG), Ponta Grossa, Paraná, Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Andre Dos Santos
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology*; D020948:Cat's Claw; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D013282:Stomatitis, Denture / Q000188:drug therapy* / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D005782:Gels; D008825:Miconazole