title: Ameliorative role of gemfibrozil against partial abdominal aortic constriction-induced cardiac hypertrophy in rats.
abstract: Fibrates are peroxisome proliferator-activated receptor-α agonists and are clinically used for treatment of dyslipidemia and hypertriglyceridemia. Fenofibrate is reported as a cardioprotective agent in various models of cardiac dysfunction; however, limited literature is available regarding the role of gemfibrozil as a possible cardioprotective agent, especially in a non-obese model of cardiac remodelling. The present study investigated the role of gemfibrozil against partial abdominal aortic constriction-induced cardiac hypertrophy in rats. Cardiac hypertrophy was induced by partial abdominal aortic constriction in rats and they survived for 4 weeks. The cardiac hypertrophy was assessed by measuring left ventricular weight to body weight ratio, left ventricular wall thickness, and protein and collagen content. The oxidative stress in the cardiac tissues was assessed by measuring thiobarbituric acid-reactive substances, superoxide anion generation, and reduced glutathione level. The haematoxylin-eosin and picrosirius red staining was used to observe cardiomyocyte diameter and collagen deposition, respectively. Moreover, serum levels of cholesterol, high-density lipoproteins, triglycerides, and glucose were also measured. Gemfibrozil (30 mg/kg, p.o.) was administered since the first day of partial abdominal aortic constriction and continued for 4 weeks. The partial abdominal aortic constriction-induced cardiac oxidative stress and hypertrophy are indicated by significant change in various parameters used in the present study that were ameliorated with gemfibrozil treatment in rats. No significant change in serum parameters was observed between various groups used in the present study. It is concluded that gemfibrozil ameliorates partial abdominal aortic constriction-induced cardiac oxidative stress and hypertrophy and in rats.
authors.affiliation: 1Department of Pharmaceutical Sciences,Guru Nanak Dev University,Amritsar 143005,India.
authors.forename: Amrit Pal
authors.initials: AP
authors.lastname: Singh
authors.affiliation: 2Department of Pharmacology,Maharishi Markandeshwar College of Pharmacy,Maharishi Markandeshwar University,Mullana,Ambala 133207,India.
authors.forename: Randhir
authors.initials: R
authors.lastname: Singh
authors.affiliation: 3Department of Pharmaceutical Sciences and Drug Research,Punjabi University,Patiala 147002,India.
authors.forename: Pawan
authors.initials: P
authors.lastname: Krishan
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000503:physiopathology; D006332:Cardiomegaly / Q000188:drug therapy* / Q000503:physiopathology*; D003250:Constriction; D004195:Disease Models, Animal; D015248:Gemfibrozil / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000960:Hypolipidemic Agents; D015248:Gemfibrozil
keywords: rats