title: Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects.
abstract: Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells that further propagate atherosclerotic inflammation. Regulatory T cells (Tregs) can suppress proinflammatory function of mature DCs. In contrast, immature DCs are able to induce Tregs and prevent differentiation of naïve T cells to proinflammatory effector T cells by initiating apoptosis and anergy in naïve T cells. Indeed, immature DCs showed tolerogenic and anti-inflammatory properties. Thus, DCs play a double role in atherosclerosis: mature DCs are proatherogenic while immature DCs appear to be anti-atherogenic. Tolerogenic and anti-inflammatory capacity of immature DCs can be therefore utilized for the development of new immunotherapeutic strategies against atherosclerosis.
authors.affiliation: Department of Medical Nanobiotechnology, Pirogov Russian State Medical University Moscow, Russia.
authors.forename: Dimitry A
authors.initials: DA
authors.lastname: Chistiakov
authors.affiliation: Skolkovo Innovative Center, Institute for Atherosclerosis Research Moscow, Russia ; Institute of General Pathology and Pathophysiology, Russian Academy of Sciences Moscow, Russia ; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex Moscow, Russia.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Sobenin
authors.affiliation: Skolkovo Innovative Center, Institute for Atherosclerosis Research Moscow, Russia ; Institute of General Pathology and Pathophysiology, Russian Academy of Sciences Moscow, Russia.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Orekhov
authors.affiliation: Skolkovo Innovative Center, Institute for Atherosclerosis Research Moscow, Russia ; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, Sydney NSW, Australia.
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Bobryshev
keywords: arteries; atherogenesis; atherosclerosis; dendritic cells; immune reactions; inflammation