title: Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra.
abstract: Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. trong.tran@griffithuni.edu.au.
authors.forename: Trong D
authors.initials: TD
authors.lastname: Tran
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. n.pham@griffith.edu.au.
authors.forename: Ngoc B
authors.initials: NB
authors.lastname: Pham
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. gregfeq@gmail.com.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fechner
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. john.hooper@qm.qld.gov.au.
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. r.quinn@griffith.edu.au.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001315:Australia; D045744:Cell Line, Tumor; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D020128:Inhibitory Concentration 50; D008297:Male; D010413:Penis / Q000166:cytology; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides