title: Review of the use of lipid emulsion in nonlocal anesthetic poisoning.
abstract: Intravenous lipid emulsion (ILE) has been used widely for the treatment of poisoning due to local anesthetic agent and is increasingly reported as a therapy for other forms of poisoning. This article will review the proposed mechanisms of action for ILE in poisoning and the evidence from animal studies and human experience supporting the use of ILE for poisoning due to nonlocal anesthetic agents.
authors.affiliation: *Associate Medical Director, Wisconsin Poison Center and †Associate Professor of Pediatrics and Emergency Medicine (Kostic); Professor of Pediatric Emergency Medicine (Gorelick), Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Kostic
authors.forename: Marc
authors.initials: M
authors.lastname: Gorelick
mesh_terms: D000779:Anesthetics, Local / Q000506:poisoning*; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids
chemical_list: D000779:Anesthetics, Local; D000931:Antidotes; D005217:Fat Emulsions, Intravenous; D008055:Lipids