title: Reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl and heteroaryl bromides.
abstract: Reductive cross-coupling allows the direct C-C bond formation between two organic halides without the need for preformation of an organometallic reagent. A method has been developed for the reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl or heteroaryl bromides. The developed conditions use an air-stable Ni(II) source in the presence of a diamine ligand and a metal reductant to allow late-stage incorporation of saturated heterocyclic rings onto aryl halides in a functional-group tolerant manner.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
authors.forename: Kaitlin M
authors.initials: KM
authors.lastname: Traister
authors.forename: Brian T
authors.initials: BT
authors.lastname: O'Neill
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D001965:Bromides; D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D008024:Ligands; D008670:Metals