title: Synthesis and biological evaluation of some new amide moiety bearing quinoxaline derivatives as antimicrobial agents.
abstract: In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]-substituted benzamide derivatives were synthesized by reacting 2,3-bis(4-methoxyphenyl)-6-aminoquinoxaline or 2,3-bis(4-methylphenyl)-6-aminoquinoxaline with benzoyl chloride derivatives in tetrahydrofuran and investigated for their antimicrobial activity. The structures of the obtained final compounds were confirmed by spectral data (IR, (1)H-NMR, (13)C-NMR and MS). The antimicrobial activity of the compounds were determined by using the microbroth dilution method. Antimicrobial activity results revealed that synthesized compounds exhibited remarkable activity against Candida krusei (ATCC 6258) and Candida parapsilosis (ATCC 22019).
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Azhar University, Gaza, Palestine.
authors.forename: U
authors.initials: U
authors.lastname: Abu Mohsen
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Yurttaş
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Acar
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Özkay
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Kaplacikli
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, Eskisehir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Karaca Gencer
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, Eskisehir, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Cantürk
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D011810:Quinoxalines