title: Causes of death among HIV-infected patients in France in 2010 (national survey): trends since 2000.
abstract: OBJECTIVE
  The Mortalité 2010 survey aimed at describing the causes of death among HIV-infected patients in France in 2010 and their evolution since 2000.
  
  
  METHODS
  A national sample of clinical sites, providing HIV care and treatment, notified and documented deaths using a standardized questionnaire.
  
  
  RESULTS
  The 90 participating wards notified 728 deaths. Median age at death was 50 years (interquartile range 45-58) and 75% were men. The main underlying causes of death were AIDS-related (25% in 2010 vs. 36% in 2005 and 47% in 2000), non-AIDS non-viral hepatitis-related malignancy (22 vs. 17 and 11%), liver-related (11 vs. 15 and 13%), cardiovascular diseases (10 vs. 8 and 7%) and non-AIDS-related infections (9 vs. 4 and 7%). Malignancies (AIDS and non-AIDS-related) accounted for a third of all causes of death. AIDS accounted for 33% of all causes of death among patients mono-infected with HIV vs. only 13% among those co-infected with hepatitis B virus or hepatitis C virus.
  
  
  CONCLUSIONS
  In 2010, 25% of the causes of death among HIV-infected patients remained AIDS-related. Improved screening and earlier HIV treatment should lead to a smaller proportion of deaths due to AIDS. The majority of patients died of various causes, whereas their HIV infection was well controlled under treatment. Improving case management of HIV-infected patients should include a multidisciplinary approach (prevention, screening, treatment), especially in oncology. Smoking cessation should be a priority goal.
authors.affiliation: aINSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistiques bService de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, CHU de Bordeaux cUniversity Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistiques, Bordeaux dService de Maladies Infectieuses, Hôpital Brabois, Vandoeuvre-Les-Nancy eUnité de Pathologie Infectieuse, Pôle Médecine, Hôpital Cochin, AP-HP fUniversité Paris Descartes gDepartment of Internal Medicine and Immunology, AP-HP Hôpital La Pitié-Salpêtrière hDépartement Hospitalo-universitaire I2B, UPMC Univ Paris 06, UMR 7211, Paris iINSERM-CépiDC, Le Kremlin-Bicêtre jService de Médecine Interne, Hôpital de l'Archet kUniversité de Nice-Sophia Antipolis, Nice lService des Maladies Infectieuses et Tropicales, Hôpital Purpan, Toulouse mService des Maladies Infectieuses et Tropicales, Hôpitaux Universitaires Paris Nord Val de Seine nUniversité Paris 7 oINSERM, UMR-S 1136 pSorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Paris qCHU de Bordeaux, Pole de Santé Publique, Bordeaux, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Morlat
authors.forename: Caroline
authors.initials: C
authors.lastname: Roussillon
authors.forename: Sandrine
authors.initials: S
authors.lastname: Henard
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonnet
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.forename: Aurore
authors.initials: A
authors.lastname: Georget
authors.forename: Albertine
authors.initials: A
authors.lastname: Aouba
authors.forename: Eric
authors.initials: E
authors.lastname: Rosenthal
authors.forename: Thierry
authors.initials: T
authors.lastname: May
authors.forename: Marie
authors.initials: M
authors.lastname: Chauveau
authors.forename: Bilghissa
authors.initials: B
authors.lastname: Diallo
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chene
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000328:Adult; D002423:Cause of Death / Q000639:trends*; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology*; D006509:Hepatitis B / Q000453:epidemiology; D006526:Hepatitis C / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors