title: Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
abstract: Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor growth is the main therapeutic objective in MPP patients. A significant number of MPP patients still die from uncontrolled hormone secretion. In addition, the management of MPPs remains palliative. Steps forward include proper characterization of MPP patients at large cancer referral centers with multidisciplinary teams; improved strategies to stratify patients prognostically; and implementation of trials within national and international networks. Progress in the molecular characterization and staging of MPPs constitutes the basis for significant treatment breakthroughs.
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA baudin@igr.fr cjimenez@mdanderson.org.
authors.forename: Eric
authors.initials: E
authors.lastname: Baudin
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Mouhammed Amir
authors.initials: MA
authors.lastname: Habra
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Frederic
authors.initials: F
authors.lastname: Deschamps
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Cote
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Frederic
authors.initials: F
authors.lastname: Dumont
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Cabanillas
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: J
authors.initials: J
authors.lastname: Arfi-Roufe
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Berdelou
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Moon
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Abir
authors.initials: A
authors.lastname: Al Ghuzlan
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Shreyaskumar
authors.initials: S
authors.lastname: Patel
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.affiliation: Département de Médecine Nucléaire et de Cancérologie EndocrinienneRadiologie Interventionnelle, Chirurgie, Imagerie, Institut Gustave Roussy, Université Paris Sud, 114 Rue Edouard Vaillant 94805 villejuif Cedex, Paris, France andDepartment of Endocrine Neoplasia and Hormone DisordersUnit 1461, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA baudin@igr.fr cjimenez@mdanderson.org.
authors.forename: Camilo
authors.initials: C
authors.lastname: Jimenez
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods; D004700:Endocrine System Diseases / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D010235:Paraganglioma / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D010673:Pheochromocytoma / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents