title: Different behavioral effect dose-response profiles in mice exposed to two-carbon chlorinated hydrocarbons: influence of structural and physical properties.
abstract: The present study aimed to clarify whether dose-response profiles of acute behavioral effects of 1,2-dichloroethane (DCE), 1,1,1-trichloroethane (TCE), trichloroethylene (TRIC), and tetrachloroethylene (PERC) differ. A test battery involving 6 behavioral endpoints was applied to evaluate the effects of DCE, TCE, TRIC, and PERC in male ICR strain mice under the same experimental conditions. The behavioral effect dose-response profiles of these compounds differed. Regression analysis was used to evaluate the relationship between the dose-response profiles and structural and physical properties of the compounds. Dose-response profile differences correlated significantly with differences in specific structural and physical properties. These results suggest that differences in specific structural and physical properties of DCE, TCE, TRIC, and PERC are responsible for differences in behavioral effects that lead to a variety of dose-response profiles.
authors.affiliation: Center for Environmental Measurement and Analysis, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan. Electronic address: umechan2@nies.go.jp.
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Umezu
authors.affiliation: Center for Environmental Measurement and Analysis, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan. Electronic address: yshibata@nies.go.jp.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shibata
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005025:Ethylene Dichlorides / Q000633:toxicity; D005247:Feeding Behavior / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D012055:Reinforcement Schedule; D013329:Structure-Activity Relationship; D013750:Tetrachloroethylene / Q000633:toxicity; D014240:Trichloroethanes / Q000633:toxicity; D014241:Trichloroethylene / Q000633:toxicity
chemical_list: D005025:Ethylene Dichlorides; D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; D014241:Trichloroethylene; C024565:ethylene dichloride; D013750:Tetrachloroethylene
keywords: Anesthetic effect; C(2) chlorinated hydrocarbons; FR20 operant; Lethality; Multiple schedule operant; Physicochemical property