title: Micrometer-size vesicle formation triggered by UV light.
abstract: Vesicle formation is a fundamental kinetic process related to the vesicle budding and endocytosis in a cell. In the vesicle formation by artificial means, transformation of lamellar lipid aggregates into spherical architectures is a key process and known to be prompted by e.g. heat, infrared irradiation, and alternating electric field induction. Here we report UV-light-driven formation of vesicles from particles consisting of crumpled phospholipid multilayer membranes involving a photoactive amphiphilic compound composed of 1,4-bis(4-phenylethynyl)benzene (BPEB) units. The particles can readily be prepared from a mixture of these components, which is casted on the glass surface followed by addition of water under ultrasonic radiation. Interestingly, upon irradiation with UV light, micrometer-size vesicles were generated from the particles. Neither infrared light irradiation nor heating prompted the vesicle formation. Taking advantage of the benefits of light, we successfully demonstrated micrometer-scale spatiotemporal control of single vesicle formation. It is also revealed that the BPEB units in the amphiphile are essential for this phenomenon.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University , 2-1-1, Katahira, Aoba-ku, Sendai 980-8577 Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Muraoka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hamada
authors.forename: Masamune
authors.initials: M
authors.lastname: Morita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takagi
authors.forename: Hajime
authors.initials: H
authors.lastname: Fukuoka
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Sagawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ishijima
authors.forename: Yuki
authors.initials: Y
authors.lastname: Omata
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamashita
authors.forename: Kazushi
authors.initials: K
authors.lastname: Kinbara
mesh_terms: D008567:Membranes, Artificial; D010743:Phospholipids / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D008567:Membranes, Artificial; D010743:Phospholipids