title: Hypoglycemic and hypolipidemic activities of Arabic and Indian origin Salvadora persica root extract on diabetic rats with histopathology of their pancreas.
abstract: OBJECTIVE
  To evaluate hypoglycemic and hypolipidemic effects of Salvadora persica aqueous extracts on streptozotocin-induced diabetic rats by measuring fasting blood glucose levels, lipid profiles and histopathological analysis of pancreas.
  
  
  METHODS
  Experimental Diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg/kg) to albino Wistar rats. Salvadora persica extracts were administered orally at 250 and 500 mg/kg dose levels for 21 days. Glucose tolerance test (GTT) was performed on 16 h fasted rats and changes in blood glucose levels, total cholesterol, triglycerides, low-density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and histopathology of pancreas were performed.
  
  
  RESULTS
  At a dose level of 500 mg/kg, blood glucose 85.25 ± 13.20 mg/dl, total cholesterol (TC) 114.57 ± 15.81(mg/dl), triglycerides (TG) 75.40 ± 16.47(mg/dl), LDL 42.63 ± 13.17(mg/dl), VLDL 22.78 ± 1.88(mg/dl), and elevation of HDL 44.88 ± 11.61(mg/dl) were found in comparison with diabetic control on 28(th) day by Arabic origin Salvadora persica. It also accelerated the regeneration of β-cells in experimental animal's pancreas to 32.6 ± 2.4 compared to diabetic control animal's pancreas of 8.1 ± 0.5 at the end of 28(th) day.
  
  
  CONCLUSIONS
  This study confirmed that Arabic Salvadora persica aqueous extracts at 500 mg/kg dose level, in comparison to other extracts (Indian Salvadora persica, 250 and 500 mg/kg, Arabic Salvadora persica 250 mg/kg) possessed significant hypoglycemic and hypolipidemic activities and regenerated pancreatic β-cells in streptozotocin treated diabetic rats.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
authors.forename: Maria
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
authors.forename: Abuzer
authors.initials: A
authors.lastname: Ali
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Mir
keywords: Salvadora persica; antidiabetic activity; geo-comparison; glucose tolerance test; histopathology; hypoglycemic activity; pancreatic β-cells; serum lipid profile