title: Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing.
abstract: Acute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with dramatic subpopulation shifts in a single acutely infected participant providing further insight into the genetic dynamics of acute HIV-1 infection.
authors.affiliation: 1 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California , Los Angeles, Los Angeles, California.
authors.forename: Laith Q
authors.initials: LQ
authors.lastname: Al-Mawsawi
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Wu
authors.forename: Justin
authors.initials: J
authors.lastname: De La Cruz
authors.forename: Vivian Cai
authors.initials: VC
authors.lastname: Shi
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wu
authors.forename: Eric S
authors.initials: ES
authors.lastname: Daar
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Lewis
authors.forename: Otto O
authors.initials: OO
authors.lastname: Yang
authors.forename: Ren
authors.initials: R
authors.lastname: Sun
mesh_terms: D000220:Adaptation, Biological; D014644:Genetic Variation; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008969:Molecular Sequence Data; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics* / Q000276:immunology
chemical_list: D054301:gag Gene Products, Human Immunodeficiency Virus