title: Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients-Case Report and Research.
abstract: BACKGROUND
  Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.
  
  
  OBJECTIVE
  Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).
  
  
  METHODS
  Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.
  
  
  RESULTS
  RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.
  
  
  CONCLUSIONS
  This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.
  
  
  CONCLUSIONS
  We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.
authors.affiliation: Head of Clinic for Integrative Dentistry, Munich, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Lechner
authors.affiliation: Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: von Baehr
keywords: RANTES/CCL5; breast cancer; jawbone; metastasis; osteonecrosis; signaling pathways