title: Formulation of cellulose film containing permeation enhancers for prolonged delivery of propranolol hydrocloride.
abstract: The aim of this study was to evaluate the capacity of cellulose films enriched with oleic acid and polysorbate 80 to enhance the transdermal permeation of propranolol hydrochloride. Polymeric films were prepared by casting and drying aqueous solutions of hydroxypropylmethylcellulose or carboxymethylcellulose and characterized in chemical-physical properties, such as drug content, thickness, morphology and water uptake capacity. In vitro transport experiments were performed in order to evaluate the permeation enhancing ability of oleic acid and polysorbate 80. All carboxymethylcellulose films showed lower cumulative amounts of drug permeated than hydroxypropylmethylcellulose. Moreover, films containing both oleic acid and polysorbate 80 provided a greater permeation in comparison to film without permeation enhancers or only with one of these. The results obtained confirm that propranolol hydrochloride permeation can be easily modulated by varying the cellulose and enhancer type used for film preparation.
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna , Bologna , Italy and.
authors.forename: Federica
authors.initials: F
authors.lastname: Bigucci
authors.forename: Angela
authors.initials: A
authors.lastname: Abruzzo
authors.forename: Teresa
authors.initials: T
authors.lastname: Cerchiara
authors.forename: Maria Caterina
authors.initials: MC
authors.lastname: Gallucci
authors.forename: Barbara
authors.initials: B
authors.lastname: Luppi
mesh_terms: D000279:Administration, Cutaneous; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives / Q000737:chemistry; D019301:Oleic Acid / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D011433:Propranolol / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D012869:Skin Absorption; D013552:Swine
chemical_list: D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D005079:Excipients; D011136:Polysorbates; D019301:Oleic Acid; D065347:Hypromellose Derivatives; D011433:Propranolol; D002266:Carboxymethylcellulose Sodium
keywords: Cellulose film; oleic acid; permeation enhancers; propranolol hydrochloride; transdermal drug delivery