title: miRNA polymorphisms and risk of gastric cancer in Asian population.
abstract: miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.
authors.affiliation: Hai-Bing Hua, Department of Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangyin 214400, Jiangsu Province, China.
authors.forename: Hai-Bing
authors.initials: HB
authors.lastname: Hua
authors.affiliation: Hai-Bing Hua, Department of Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangyin 214400, Jiangsu Province, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Yan
authors.affiliation: Hai-Bing Hua, Department of Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangyin 214400, Jiangsu Province, China.
authors.forename: Qing-Min
authors.initials: QM
authors.lastname: Sun
mesh_terms: D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor; D063646:Carcinogenesis; D020868:Gene Silencing; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Gastric cancer; Polymorphism; Risk; miRNA