title: Cryogels-versatile tools in bioseparation.
abstract: Cryogels are polymeric materials formed from monomeric or polymeric precursors in moderately frozen state by polymerization or crosslinking. The process applied for cryogel formation is called cryogelation. These macroporous gel matrices can be produced with different shapes and the gels are of interest in the bioseparation area since they can meet needs that conventional chromatographic media are less suitable to fulfill. High porosity, high mechanical and chemical stability make them appropriate carriers for immobilization of biomolecules and cells thereby making them attractive gel matrices for separation and purification of various molecules. This review highlights the preparation and properties of cryogels, and applications of these materials especially in bioseparation science.
authors.affiliation: Department of Biotechnology, Lund University, Lund, Sweden.
authors.forename: Gizem
authors.initials: G
authors.lastname: Ertürk
authors.affiliation: Department of Biotechnology, Lund University, Lund, Sweden; Indienz AB, Annebergs Gård PL 5520, Se-26873 Billeberga, Sweden. Electronic address: bo.mattiasson@biotek.lu.se.
authors.forename: Bo
authors.initials: B
authors.lastname: Mattiasson
mesh_terms: D002845:Chromatography / Q000295:instrumentation* / Q000379:methods; D059985:Cryogels / Q000138:chemical synthesis* / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D016062:Porosity; D018508:Water Purification / Q000295:instrumentation / Q000379:methods
chemical_list: D059985:Cryogels; D011108:Polymers
keywords: Bioseparation science; Cryogel; Cryogelation; Immobilization; Purification; Separation