title: Nano/micro and spectroscopic approaches to food pathogen detection.
abstract: Despite continuing research efforts, timely and simple pathogen detection with a high degree of sensitivity and specificity remains an elusive goal. Given the recent explosion of sensor technologies, significant strides have been made in addressing the various nuances of this important global challenge that affects not only the food industry but also human health. In this review, we provide a summary of the various ongoing efforts in pathogen detection and sample preparation in areas related to Fourier transform infrared and Raman spectroscopy, light scattering, phage display, micro/nanodevices, and nanoparticle biosensors. We also discuss the advantages and potential limitations of the detection methods and suggest next steps for further consideration.
authors.affiliation: Bindley Bioscience and Birck Nanotechnology Center; Departments of.
authors.forename: Il-Hoon
authors.initials: IH
authors.lastname: Cho
authors.forename: Adarsh D
authors.initials: AD
authors.lastname: Radadia
authors.forename: Khashayar
authors.initials: K
authors.lastname: Farrokhzad
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ximenes
authors.forename: Euiwon
authors.initials: E
authors.lastname: Bae
authors.forename: Atul K
authors.initials: AK
authors.lastname: Singh
authors.forename: Haley
authors.initials: H
authors.lastname: Oliver
authors.forename: Michael
authors.initials: M
authors.lastname: Ladisch
authors.forename: Arun
authors.initials: A
authors.lastname: Bhunia
authors.forename: Bruce
authors.initials: B
authors.lastname: Applegate
authors.forename: Lisa
authors.initials: L
authors.lastname: Mauer
authors.forename: Rashid
authors.initials: R
authors.lastname: Bashir
authors.forename: Joseph
authors.initials: J
authors.lastname: Irudayaraj
mesh_terms: D001419:Bacteria / Q000472:pathogenicity*; D015374:Biosensing Techniques / Q000379:methods*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods*
keywords: biosensors; detection; food pathogen; molecular biology; spectroscopy