title: CARTs on the road for myeloma.
abstract: Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expands the possible indications for chimeric-antigen receptor (CAR) T cells. CS1 is expressed at high levels by multiple myeloma cells, but also to some extent on other lymphocytes. CS1 may be a viable target for CAR T cells in multiple myeloma.
authors.affiliation: Translational Research Program, Abramson Cancer Center; Departments of Medicine and.
authors.forename: Marcela V
authors.initials: MV
authors.lastname: Maus
authors.affiliation: Translational Research Program, Abramson Cancer Center; Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania cjune@exchange.upenn.edu.
authors.forename: Carl H
authors.initials: CH
authors.lastname: June
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005818:Genetic Engineering; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000517:prevention & control*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic