title: A mineral and antioxidant-rich extract from the red marine Algae Alsidium corallinum exhibits cytoprotective effects against potassium bromate-induced erythrocyte oxidative damages in mice.
abstract: The present study was carried out to investigate potassium bromate toxicity in mice and the corrective effects of marine algae Alsidium corallinum. The red algae demonstrated its rich composition in phenols, triterpenes, flavonoids, alkaloids, tropolones, sodium, potassium, calcium, magnesium, iron, copper, and zinc. To confirm its antioxidant potential, an in vivo study was performed on adult mice. The animals were divided into four groups: group I were used as controls, group II received potassium bromate (0.5 g/L) via drinking water, group III received potassium bromate (0.5 g/L) by the same route as group II and 7% of A. corallinum ethanolic extract via their diet, and group IV received only 7% of algae. The potassium bromate-treated group showed a significant decrease in erythrocyte, platelet, hemoglobin, and hematocrit values and a significant increase in total white blood cells, compared to those of controls. While, superoxide dismutase, catalase, glutathione, and vitamin C values were decreased by potassium bromate treatment, lipid peroxidation (as malondialdehyde) and erythrocyte osmotic fragility values were increased. Interestingly, potassium bromate treatment showed significant genotoxic effects, as demonstrated by DNA degradation. These changes were confirmed by blood smears histopathological observations which were marked by a necrosis and a decrease of erythrocytes number. A. corallinum extract appeared to be effective against hematotoxic and genotoxic changes induced by potassium bromate, as evidenced by the improvement of the parameters cited above.
authors.affiliation: Animal Physiology Laboratory, Faculty of Sciences, Sfax University, BP 1171, 3000, Sfax, Tunisia.
authors.forename: Hajer
authors.initials: H
authors.lastname: Ben Saad
authors.forename: Imen
authors.initials: I
authors.lastname: Nasri
authors.forename: Awatef
authors.initials: A
authors.lastname: Elwej
authors.forename: Najeh
authors.initials: N
authors.lastname: Krayem
authors.forename: Raoudha
authors.initials: R
authors.lastname: Jarraya
authors.forename: Choumous
authors.initials: C
authors.lastname: Kallel
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal
authors.forename: Ibtissem Ben
authors.initials: IB
authors.lastname: Amara
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D001959:Bromates / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D053938:DNA Fragmentation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005290:Ferric Compounds / Q000378:metabolism; D005419:Flavonoids / Q000032:analysis; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000097:blood; D051379:Mice; D008903:Minerals / Q000032:analysis / Q000494:pharmacology*; D009996:Osmotic Fragility / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000032:analysis; D019163:Reducing Agents / Q000737:chemistry; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001959:Bromates; D002273:Carcinogens; D005290:Ferric Compounds; D005419:Flavonoids; D008903:Minerals; D010636:Phenols; D019163:Reducing Agents; C019536:potassium bromate; D007770:L-Lactate Dehydrogenase