title: Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants.
abstract: OBJECTIVE
  We attempted to investigate whether dehydroepiandrosterone sulfate (DHEA-S) levels are associated with remission of major depressive disorder by assessing scores on the 17-Item Structured Interview Guide for the Hamilton Depression before and after antidepressant treatment.
  
  
  METHODS
  Plasma DHEA-S levels in 24 patients diagnosed with major depressive disorder on the basis of Diagnostic and Statistical Manual of Mental Disorders, fourth edition (text revision) before and after antidepressant treatment, and 24 healthy, gender-matched, and age-matched controls were measured using a radioimmunoassay kit.
  
  
  RESULTS
  Plasma DHEA-S levels in patients were significantly higher than those in healthy controls. In patients who achieved remission after antidepressant treatment, plasma DHEA-S levels significantly declined compared with the levels before treatment. A significant correlation was observed between changes in DHEA-S levels and Absence of Depressive and Anxious Mood scores, which are calculated from the 2-Item Structured Interview Guide for the Hamilton Depression rating as follows: severity of depressive mood and anxiety in patients before and after antidepressant treatment.
  
  
  CONCLUSIONS
  These findings suggest that plasma DHEA-S levels can be used as a putative indicator of the state of remission in patients with major depressive disorder. Copyright © 2014 John Wiley & Sons, Ltd.
authors.affiliation: Department of Physiology, Meijo University, Graduate School of Pharmacy, Nagoya, Japan; Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Japan.
authors.forename: Tokiko
authors.initials: T
authors.lastname: Morita
authors.forename: Koji
authors.initials: K
authors.lastname: Senzaki
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishihara
authors.forename: Kazunori
authors.initials: K
authors.lastname: Umeda
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Taku
authors.initials: T
authors.lastname: Nagai
authors.forename: Hirotake
authors.initials: H
authors.lastname: Hida
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yukawa
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Noda
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001774:Blood Chemical Analysis / Q000379:methods; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay; D012074:Remission Induction; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D019314:Dehydroepiandrosterone Sulfate
keywords: Absence of Depressive and Anxious Mood (ADAM) score; dehydroepiandrosterone sulfate (DHEA-S); major depressive disorder; remission