title: Power of proteomics in linking oxidative stress and female infertility.
abstract: Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways in differential expression of proteins and in these diseases. The emerging field of proteomics has allowed identification of proteins involved in cell cycle, as antioxidants, extracellular matrix (ECM), cytoskeleton, and their linkage to oxidative stress in female infertility related diseases. The aim of this paper is to assess the association of oxidative stress and protein expression in the reproductive microenvironments such as endometrial fluid, peritoneal fluid, and follicular fluid, as well as reproductive tissues and serum. The review also highlights the literature that proposes the use of the fertility related proteins as potential biomarkers for noninvasive and early diagnosis of the aforementioned diseases rather than utilizing the more invasive methods used currently. The review will highlight the power of proteomic profiles identified in infertility related disease conditions and their linkage with underlying oxidative stress. The power of proteomics will be reviewed with regard to eliciting molecular mechanisms for early detection and management of these infertility related conditions.
authors.affiliation: Center for Reproductive Medicine, Cleveland Clinic Foundation, 10681 Carnegie Avenue, Desk X11, Cleveland, OH 44195, USA.
authors.forename: Sajal
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Center for Reproductive Medicine, Cleveland Clinic Foundation, 10681 Carnegie Avenue, Desk X11, Cleveland, OH 44195, USA.
authors.forename: Jana
authors.identifier: 0000-0003-4622-5777
authors.initials: J
authors.lastname: Ghulmiyyah
authors.affiliation: Center for Reproductive Medicine, Cleveland Clinic Foundation, 10681 Carnegie Avenue, Desk X11, Cleveland, OH 44195, USA.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Center for Reproductive Medicine, Cleveland Clinic Foundation, 10681 Carnegie Avenue, Desk X11, Cleveland, OH 44195, USA.
authors.forename: Jacques
authors.identifier: 0000-0002-7736-633X
authors.initials: J
authors.lastname: Halabi
authors.affiliation: Center for Reproductive Medicine, Cleveland Clinic Foundation, 10681 Carnegie Avenue, Desk X11, Cleveland, OH 44195, USA.
authors.forename: Ashok
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D001202:Ascitic Fluid; D015415:Biomarkers / Q000378:metabolism*; D004717:Endometrium; D005260:Female; D015571:Follicular Fluid / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods; D012098:Reproduction
chemical_list: D015415:Biomarkers; D020543:Proteome