title: Improved synthetic route to methyl 1-fluoroindan-1-carboxylate (FICA Me ester) and 4-methyl derivatives.
abstract: An improved synthetic route has been developed for the preparation of methyl 1-fluoroindan-1-carboxylate (FICA Me ester) from 1-indanone. Methyl 4-methyl-1-fluoroindan-1-carboxylate (4-Me-FICA Me ester) was also prepared following the same procedure.
authors.affiliation: Faculty of Pharmaceutical Sciences, Josai International University.
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Koyanagi
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Kamei
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters; D054879:Halogenation; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation
chemical_list: D002264:Carboxylic Acids; D004952:Esters; D007189:Indans