title: Association between urine aldosterone and diastolic function in patients with primary aldosteronism and essential hypertension.
abstract: OBJECTIVE
  To investigate the association between aldosterone and cardiac diastolic dysfunction.
  
  
  METHODS
  We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed.
  
  
  RESULTS
  PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function.
  
  
  CONCLUSIONS
  Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.
authors.affiliation: Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
authors.forename: Yi-Yao
authors.initials: YY
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Taipei City Hospital, Zhongxing Branch, Taipei, Taiwan; Institution of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
authors.forename: Hsiu-Hao
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Chi-Sheng
authors.initials: CS
authors.lastname: Hung
authors.affiliation: Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Wu
authors.affiliation: Department of Laboratory Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
authors.forename: Jen-Kuang
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Shuo-Meng
authors.initials: SM
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
authors.forename: Min-Tsun
authors.initials: MT
authors.lastname: Liao
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Ying-Hsien
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Vin-Cent
authors.initials: VC
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Kwan-Dun
authors.initials: KD
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: austinr34@gmail.com.
authors.forename: Yen-Hung
authors.initials: YH
authors.lastname: Lin
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood / Q000652:urine*; D004452:Echocardiography / Q000379:methods; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000503:physiopathology* / Q000652:urine*; D006973:Hypertension / Q000097:blood / Q000503:physiopathology* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000503:physiopathology / Q000652:urine; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D000450:Aldosterone
keywords: Diastolic dysfunction; Primary aldosteronism; Urine aldosterone