title: Development of a (68)Ga-Fluorinated Porphyrin Complex as a Possible PET Imaging Agent.
abstract: OBJECTIVE
  Due to the interesting pharmacologic properties of porphyrins, the idea of developing a possible tumor imaging agent using PET by incorporating (68)Ga into a suitable porphyrin ligand was investigated.
  
  
  METHODS
  (68)Ga-labeled 5,10,15,20-tetrakis(pentafluoro-13 phenyl) porphyrin ((68)Ga-TFPP) was prepared using freshly eluted [(68)Ga]GaCl3 obtained from a 68Ge/68Ga generator developed in-house and 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (H2TFPP) for 60 min at 100°C.
  
  
  RESULTS
  The complex was prepared with high radiochemical purity (>99% ITLC, >99% HPLC, specific activity: 13-14 GBq/mmol). Stability of the complex was checked in the final formulation and in human serum for 5 h. The partition coefficient was calculated for the compound (log P = 0.62). The biodistribution of the labeled compound in vital organs of Swiss mice bearing fibrosarcoma tumors was studied using scarification studies and SPECT imaging up to 1 h. The complex was mostly washed out from the circulation through kidneys and liver. The tumor-to-muscle ratio 1 h post injection was 5.13.
  
  
  CONCLUSIONS
  The radiolabeled porphyrin complex demonstrated potential for further imaging studies in other tumor models.
authors.affiliation: Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 31485-498, Karaj, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Fazaeli
authors.affiliation: Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box:14395-836, Tehran, Iran.
authors.forename: Amir R
authors.initials: AR
authors.lastname: Jalilian
authors.affiliation: Department of Chemistry, Shahid Beheshti University, G.C., P.O. Box 19396-4716, Tehran, Iran.
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Amini
authors.affiliation: Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 31485-498, Karaj, Iran.
authors.forename: Khosro
authors.initials: K
authors.lastname: Ardaneh
authors.affiliation: Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 31485-498, Karaj, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rahiminejad
authors.affiliation: Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 31485-498, Karaj, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Bolourinovin
authors.affiliation: Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 31485-498, Karaj, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Moradkhani
authors.affiliation: Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 31485-498, Karaj, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Majdabadi
keywords: Biodistribution; Co-incidence; Fibrosarcoma; Ga-68; Porphyrins