title: [Nodular histiocytic/mesothelial hyperplasia: a clinicopathologic analysis of 7 cases].
abstract: OBJECTIVE
  To analyze the clinicopathologic and immunohistochemical features of nodular histiocytic/mesothelial hyperplasia (NHMH) and to improve the knowledge of this disease.
  
  
  METHODS
  Seven cases of NHMH were collected and the clinicopathologic and immunohistochemical data were analyzed with review of the literature.
  
  
  RESULTS
  Seven male patients aged from 1.5 to 5.0 years (mean 2.8). The main clinical symptom was an inguinal mass.Grossly, main pathological changes were the mural nodule or free nodule in lumen, with diameter of 0.1-0.5 cm.Histologically, the tumor cell morphology was relatively single, cohesive polygonal or oval cells which were arranged in solid sheets or nests, usually with ovoid or deeply grooved nuclei and a moderate amount of pale pink cytoplasm in the nodular collection area. The nuclei had delicate chromatin and no obvious atypia, and mitosis was incidentally found. A few scattered lymphocytes were found in the stroma. The cyst wall was lined by a single layer of mesothelial cells.Immunohistochemically, the most cells in nodular lesion were strongly positive for the histiocytic marker CD68, vimentin and α1-antichymotrypsin, while lining mesothelial cells on the wall were positive for calretinin, MC, WT1, CK5/6, CKpan and EMA.
  
  
  CONCLUSIONS
  NHMH is a rare and benign tumor-like lesion, and easy to be misdiagnozed, which should be distinguished from neuroendocrine tumors, Langerhans cell histiocytosis, seminoma, mesothelioma and so on. The correct diagnosis of this lesion depends on the clinical characteristics, morphology and immunohistochemistry.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233003, China. E-mail: chzgen@163.com.
authors.forename: Zhaogen
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233003, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233003, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233003, China.
authors.forename: Bingqin
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233003, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233003, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D064032:Calbindin 2 / Q000378:metabolism; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004848:Epithelium / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D007223:Infant; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008297:Male; D008654:Mesothelioma / Q000378:metabolism / Q000473:pathology; D018396:Mucin-1 / Q000378:metabolism; D018358:Neuroendocrine Tumors / Q000378:metabolism / Q000473:pathology; D018239:Seminoma / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000378:metabolism; D025721:WT1 Proteins / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D064032:Calbindin 2; D017493:Leukocyte Common Antigens; D018396:Mucin-1; D014746:Vimentin; D025721:WT1 Proteins; D000514:alpha 1-Antichymotrypsin; C067980:CD68 antigen, human; D000097382:CD68 Molecule