title: Broadening the scope of Baeyer-Villiger monooxygenase activities toward α,β-unsaturated ketones: a promising route to chiral enol-lactones and ene-lactones.
abstract: Three regiodivergent Baeyer-Villiger mono-oxygenases (enantioselectively) oxidized a series of cyclic α,β-unsaturated ketones into (chiral) either enol-lactones or ene-lactones. An easy-to-use and efficient biocatalytic process based on a host-microorganism deprived of unwanted activities (knock-out mutant) was developed to enable the exclusive synthesis of unsaturated lactones.
authors.affiliation: Aix Marseille Université, Centrale Marseille, CNRS iSm2 UMR 7313, 13397 Marseille, France. v.alphand@univ-amu.fr.
authors.forename: T
authors.initials: T
authors.lastname: Reignier
authors.forename: V
authors.initials: V
authors.lastname: de Berardinis
authors.forename: J-L
authors.initials: JL
authors.lastname: Petit
authors.forename: A
authors.initials: A
authors.lastname: Mariage
authors.forename: K
authors.initials: K
authors.lastname: Hamzé
authors.forename: K
authors.initials: K
authors.lastname: Duquesne
authors.forename: V
authors.initials: V
authors.lastname: Alphand
mesh_terms: D001711:Biotransformation; D004926:Escherichia coli / Q000201:enzymology; D007659:Ketones / Q000378:metabolism*; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D007783:Lactones; D010105:Oxygenases