title: Hsp90 picks PIKKs via R2TP and Tel2.
abstract: Phosphatidylinositol-3 kinase-like kinases (PIKKs) are dependent on Hsp90 for their activation via the R2TP complex and Tel2. In this issue of Structure, Pal and colleagues present the molecular mechanism by which PIKKs are recruited to Hsp90.
authors.affiliation: Institute of Structural and Molecular Biology, Birkbeck College and University College London, Malet Street, London WC1E 7HX, UK. Electronic address: c.vaughan@mail.cryst.bbk.ac.uk.
authors.forename: Cara K
authors.initials: CK
authors.lastname: Vaughan
mesh_terms: D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry* / Q000378:metabolism*; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: C074510:HSP82 protein, S cerevisiae; D018841:HSP90 Heat-Shock Proteins; D009687:Nuclear Proteins; C497702:PIH1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C444420:Tel2 protein, S cerevisiae; D034501:Telomere-Binding Proteins