title: Protein kinase C inhibitors for immune disorders.
abstract: Protein kinase C (PKC) proteins are a group of well-conserved, intracellular signaling enzymes expressed in all cells and tissues, including immune cells. Much of the molecular insight into PKC immunobiology has been gleaned from studies using PKC gene (Prkc) knockout mice and the analysis of different disease models in these animals. More-recent studies have revealed that PKCs also have crucial roles in the pathogenesis of human immune disorders. Therefore, strategies to modulate the functions of PKC enzymes could have a major impact on the treatment and therapies of autoimmune diseases and other immune disorders.
authors.affiliation: Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
authors.forename: Amnon
authors.initials: A
authors.lastname: Altman
authors.affiliation: Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Electronic address: kfkong@liai.org.
authors.forename: Kok-Fai
authors.initials: KF
authors.lastname: Kong
mesh_terms: D000818:Animals; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy* / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D047428:Protein Kinase Inhibitors; D011493:Protein Kinase C