title: [Study of quality of life in adults with common variable immunodeficiency by using the Questionnaire SF-36].
abstract: BACKGROUND
  Quality of life is a multidimensional concept that includes physical, emotional and social components associated with the disease. The use of tools to assess the Quality of Life Health Related (HRQOL) has increased in recent decades. Common variable immunodeficiency (CVID) is the most commonly diagnosed primary immunodeficiency.
  
  
  OBJECTIVE
  To evaluate the quality of life in patients with CVID using the questionnaire SF -36.
  
  
  METHODS
  A descriptive cross-sectional survey included 23 patients diagnosed with CVID, belonging to the Immunodeficiency Clinic Service of Allergology and Clinical Immunology in CMN Siglo XXI, IMSS. The questionnaire SF- 36 validated in Spanish was applied.
  
  
  METHODS
  descriptive statistics with simple frequencies and percentages, inferential statistics: Fisher exact test and ANOVA to compare means.
  
  
  RESULTS
  The study involved 23 patients, 14 women (60%) and 9 men (40%), mean age 38.6 ± 14.7 years. The highest score was obtained in 83% emotional role. Dimensions with further deterioration in both genders were: 54% general health, vitality 59% and physical performance 72%. No differences were found regarding gender. The only issue in which statistically significant differences were found in patients with more than 3 comorbidities was change in health status in the past year (p=0.007). Patients with severe comorbidities, such as haematologicaloncological (leukemias, lymphomas, neoplasms), and pulmonary (severe bronchiectasis) showed further deterioration in the aspects of physical performance 73% and 64% emotional role. 65% of patients reported an improvement in health status in 74% in the last year.
  
  
  CONCLUSIONS
  Adult patients with CVID show deterioration in different dimensions, particularly in the areas of general health, vitality and physical performance. Patients with severe comorbidities such as leukemia, lymphomas, malignancies and severe bronchiectasis show further deterioration in some aspects of quality of life, especially in physical performance and emotional role. A higher number of comorbidities was significantly associated with a lower score in changing health. The questionnaire SF-36 is useful for evaluating the quality of life of our patients with CVID.
authors.affiliation: Servicio de Alergia e Inmunología Clínica, Hospital de Especialidades Dr. Bernardo Sepúlveda Gutiérrez, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, DF. pati333@hotmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: López-Pérez
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Miranda-Novales
authors.forename: Nora Hilda
authors.initials: NH
authors.lastname: Segura-Méndez
authors.forename: Leonel
authors.initials: L
authors.lastname: Del Rivero-Hernández
authors.forename: Cesar
authors.initials: C
authors.lastname: Cambray-Gutiérrez
authors.forename: Aurora
authors.initials: A
authors.lastname: Chávez-García
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires
keywords: Common variable immunodeficiency; Quality of life; Questionnaire SF-36