title: KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue.
abstract: Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.
authors.affiliation: Graduate School of Pharmaceutical Sciences.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamakoshi
authors.affiliation: Graduate School of Pharmaceutical Sciences.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanoh
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Chieko
authors.initials: C
authors.lastname: Kudo
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sato
authors.affiliation: Graduate School of Pharmaceutical Sciences.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ueda
authors.affiliation: Chemical Biology Department, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Muroi
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kon
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Satake
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Ohori
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Chikashi
authors.initials: C
authors.lastname: Ishioka
authors.affiliation: Graduate School of Pharmaceutical Sciences.
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima
authors.affiliation: Chemical Biology Department, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.affiliation: Institute of Development, Aging and Cancer.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Chiba
authors.affiliation: Department of Clinical Oncology, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shibata
authors.affiliation: Graduate School of Pharmaceutical Sciences.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Iwabuchi
keywords: KSRP/FUBP2; anticancer; bis(arylmethylidene)acetone; c-Myc; curcumin analogue; target protein