title: GO-COO-HP-β-CD nanosphere: a complex construction and its drug-loading properties.
abstract: A novel nanosphere based on carboxylated GO (GO-COOH) and hydroxypropyl-beta-CD (HP-β-CD) was synthesized to construct a complex of GO-COO-HP-β-CD. The complex formation process was studied using spectral characterization and transmission electron microscopy (TEM). X-ray diffraction and energy dispersive spectroscopy patterns show that HP-β-CD molecules either cover or intercalate into GO-COOH interlayers in the complex. Fourier transform infrared spectroscopy results indicate that GO-COOH and HP-β-CD are linked with covalent bonds formed via esterification. When employed as nanohybrid drug carriers for dexamethasone, the inclusion displays good dispersibility validated by dynamic light scattering (DLS). Cytotoxicity assays and hemolysis testing demonstrate that the nanospheres possess good biological compatibility. The loading capacity of dexamethasone is as high as 32.33%, with loading efficiency 64.66%.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, People's Republic of China. Jiangsu Engineering Research Center for Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, People's Republic of China.
authors.forename: Yunting
authors.initials: Y
authors.lastname: Fan
authors.forename: Qiuying
authors.initials: Q
authors.lastname: Sun
authors.forename: Hao
authors.initials: H
authors.lastname: Gu
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Ninglin
authors.initials: N
authors.lastname: Zhou
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D054118:Nanospheres / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D011108:Polymers; D003907:Dexamethasone