title: Photodynamic therapy of experimental sarcoma M-1 with boronated chlorine as a photosensitizer.
abstract: Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. Laser irradiation was performed at energy densities of 150, 300 J/cm(2) and power density of 0.25 and 0.42 W/cm(2). Treatment efficacy was evaluated by the percentage of animals with complete tumor regression, percentage of tumor recurrence and, in cases of its growth, by tumor growth coefficient. The efficacy of photodynamic therapy depended on the dose of boronated chlorine and parameters of the laser irradiation. Optimal conditions were the dose of 2.5 mg/kg at laser energy density of 300 J/cm(2) and power density of 0.42 W/cm(2) and a dose of 5.0 mg/kg at 150 J/cm(2) and 0.25 W/cm(2).
authors.affiliation: Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Kaplan
authors.forename: V A
authors.initials: VA
authors.lastname: Ol'shevskaya
authors.forename: Yu S
authors.initials: YS
authors.lastname: Osipchuk
authors.forename: R G
authors.initials: RG
authors.lastname: Nikitina
authors.forename: V N
authors.initials: VN
authors.lastname: Kalinin
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D021461:Animals, Outbred Strains; D001880:Boranes / Q000138:chemical synthesis / Q000494:pharmacology*; D002713:Chlorine / Q000737:chemistry*; D004307:Dose-Response Relationship, Radiation; D007274:Injections, Intraperitoneal; D054023:Lasers, Semiconductor; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D001880:Boranes; D017319:Photosensitizing Agents; D002713:Chlorine