title: The interplay between sympathetic overactivity, hypertension and heart rate variability (review, invited).
abstract: The control of arterial pressure is a complex interaction of the long- and short-term influences of hormones, local vascular factors, and neural mechanisms. The autonomic nervous system and its sympathetic arm play important roles in the regulation of blood pressure, and overactivity of sympathetic nerves may have an important role in the development of hypertension and related cardiovascular disorders. The baroreceptor system opposes either increases or decreases in arterial pressure, and the primary purpose of the arterial baroreflex is to keep blood pressure close to a particular set point over a relatively short period of time. The ability of the baroreflex to powerfully buffer acute changes in arterial pressure is well established, but the role of the arterial baroreceptor reflex in long-term control of arterial pressure has been a topic of many debate and controversy for decades. The sympathetic nervous system and arterial baroreceptor reflex control of renal sympathetic nerve activity has been proposed to play a role in long-term control of arterial pressure. The aim of this paper has been to review the postulated role of sympathetic activation.
authors.affiliation: University of Osijek Department of Physiology and Immunology, Faculty of Medicine J. Huttlera 4 31000 Osijek Croatia University of Pécs Pécs Hungary.
authors.forename: Ines
authors.initials: I
authors.lastname: Drenjancevic
authors.affiliation: University of Osijek Department of Physiology and Immunology, Faculty of Medicine J. Huttlera 4 31000 Osijek Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Grizelj
authors.affiliation: Clinical Hospital Center Osijek Department of Anesthesiology, Reanimatology and Intensive Care Unit Osijek Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Harsanji-Drenjancevic
authors.affiliation: University of Osijek Department of Physiology and Immunology, Faculty of Medicine J. Huttlera 4 31000 Osijek Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Cavka
authors.affiliation: Clinical Hospital Center Osijek Department of Cardiology, Clinic of Internal Medicine Osijek Croatia University of Osijek Department of Internal Medicine, Medical Ethic and History of Medicine, Faculty of Medicine Osijek Croatia.
authors.forename: K
authors.initials: K
authors.lastname: Selthofer-Relatic
mesh_terms: D000818:Animals; D062186:Arterial Pressure; D017704:Baroreflex; D002319:Cardiovascular System / Q000294:innervation*; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation; D011311:Pressoreceptors / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors
keywords: baroreflex; blood pressure; cardiovascular disease; hypertension; sympathetic nervous system