title: TP53 mutations and lung cancer: not all mutations are created equal.
abstract: Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others.
authors.affiliation: Department of Medicine and Alvin J Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri. rgovinda@wustl.edu.
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Govindan
authors.affiliation: Department of Medicine and Alvin J Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Jason
authors.initials: J
authors.lastname: Weber
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53