title: Efficiency of hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of graded levels of aflatoxin B1 in broiler chicks.
abstract: The objective of this study was to evaluate the efficiency of a hydrated sodium calcium aluminosilicate (HSCAS) adsorbent to ameliorate the adverse effects of 0.5 to 2 mg of aflatoxin B1 (AFB1)/kg in broiler chicks. The study consisted of 8 dietary treatments, including 4 concentrations of AFB1 (0, 0.5, 1, and 2 mg/kg) with or without HSCAS (0.5%) fed to 8 replicate cages per diet (6 males chicks per cage) from 0 to 21 d of age. Cumulative feed intake, BW gain (P < 0.0001), and G:F (P = 0.004) of birds fed the 2 mg of AFB1/kg of diet were significantly lower in comparison with birds fed 0 to 1 mg of AFB1/kg. Relative liver weight was increased in the 2 mg of AFB1/kg group (P < 0.0001). Dietary HSCAS improved cumulative BW gain (main effect P = 0.06), particularly from 14 to 21 d of age (P = 0.037). Dietary HSCAS also reversed the increase in relative liver weight for birds fed AFB1 (P = 0.019). Dietary AFB1 negatively affected major serum parameters (albumin, total protein, globulin, phosphorus, glucose, alkaline phosphatase, and creatine phosphokinase), whereas supplementation with HSCAS partially alleviated the affected serum biochemistry. In addition, serum complement activity and liver gene expression were negatively affected by 2 mg of AFB1/kg. The HSCAS supplement increased the liver expression of catalase and superoxide dismutase (P < 0.05). Results from this study indicate that dietary supplementation with HSCAS can effectively improve BW gain and partially ameliorate aflatoxicosis for broiler chicks fed AFB1-contaminated feeds.
authors.affiliation: Department of Animal Sciences, Purdue University, West Lafayette, IN 47906.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.affiliation: JBS United Inc., Sheridan, IN 46069.
authors.forename: N
authors.initials: N
authors.lastname: Horn
authors.affiliation: Department of Animal Sciences, Purdue University, West Lafayette, IN 47906 applegt@purdue.edu.
authors.forename: T J
authors.initials: TJ
authors.lastname: Applegate
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity*; D000538:Aluminum Silicates; D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001774:Blood Chemical Analysis / Q000662:veterinary; D002645:Chickens / Q000254:growth & development / Q000502:physiology*; D003165:Complement System Proteins / Q000378:metabolism; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D015651:Mycotoxicosis / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000538:Aluminum Silicates; D000975:Antioxidants; C087965:sodium calcium aluminosilicate, hydrated; D003165:Complement System Proteins; D016604:Aflatoxin B1
keywords: aflatoxin; aluminosilicate; broiler; gene expression; liver