title: Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular amination: regioselective synthesis of N1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase.
abstract: A sulfur-modified gold-supported palladium material (SAPd) has been developed bearing palladium nanoparticles on its surface. Herein, we report for the first time the use of SAPd to affect a Pd-nanoparticle-catalyzed 1,7-Pd migration reaction for the synthesis of benzotriazoles via C-H bond activation. The resulting benzotriazoles were evaluated in terms of their inhibitory activity toward indoleamine 2,3-dioxygenase.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University , Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Takagi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Amin
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hoshiya
authors.forename: Johan
authors.initials: J
authors.lastname: Wouters
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Shiro
authors.forename: Hayato
authors.initials: H
authors.lastname: Fukuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shuto
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Arisawa
mesh_terms: D000586:Amination; D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D014230:Triazoles; D010165:Palladium; C012771:benzotriazole