title: A major hindrance in antibody affinity maturation investigation: we never succeeded in falsifying the hypothesis of single-step selection.
authors.affiliation: Systems Immunology Laboratory, Department of Biology, Humboldt-Universität zu Berlin , Berlin , Germany ; Research Center ImmunoSciences, Charité-Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Michal
authors.initials: M
authors.lastname: Or-Guil
authors.affiliation: Area of Immunology, Faculty of Biology, Biomedical Research Center (CINBIO), Universidade de Vigo , Vigo , Spain ; Instituto Biomédico de Vigo , Vigo , Spain ; Instituto Gulbenkian de Ciência , Oeiras , Portugal.
authors.forename: Jose
authors.initials: J
authors.lastname: Faro
keywords: V gene sequences; antibody affinity maturation; phylogenetic trees; selection mechanism; somatic hypermutation