title: Structure elucidation of meroterpenoid habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5.
abstract: A novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, habiterpenol (1), was isolated from the culture broth of Phytohabitans suffuscus 3787_5. The planar structure of 1 was elucidated by spectroscopic study (1D and 2D NMR, MS, UV and IR), and the relative stereochemistry was elucidated by ROESY experiments. Compound 1 belongs to a pentacyclic meroterpenoid having a labdan-type diterpene connecting to an indane moiety.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yokota
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
mesh_terms: D001761:Bleomycin / Q000494:pharmacology; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D019169:Jurkat Cells; D008848:Micromonosporaceae / Q000378:metabolism*; D013057:Spectrum Analysis / Q000379:methods*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D014315:Triterpenes; C000594660:habiterpenol; D001761:Bleomycin