title: Changes of antithroglobulin antibody in children with congenital hypothyroidism.
abstract: OBJECTIVE
  It has been reported that antithroglobulin (anti-TG) antibody is increased in the sera of both children with transient congenital hypothyroidism and their mothers. And transplacental transport of thyroid autoantibody was proposed as the pathogenesis of transient congenital hypothyroidism. However this is not known in nontransient congenital hypothyroidism. This study was done to see changes of anti-TG antibody in children with nontransient congenital hypothyroidism.
  
  
  METHODS
  Study patients consisted of 60 patients diagnosed as congenital hypothyroidism in the Department of Pediatrics, Kyungpook National University Children's Hospital, Daegu, Republic of Korea between January 2010 and March 2013. Healthy control were 45 children showing normal thyroid function. Anti-TG antibody and various laboratory tests were analyzed retrospectively, and compared in both children with congenital hypothyroidism and controls.
  
  
  RESULTS
  Anti-TG antibody was significantly higher in children with congenital hypothyroidism compared to healthy controls, 119.4±34.7 U/mL versus 80.6±19.6 U/mL, respectively (P<0.001). There was no significant difference of anti-TG antibody in gender and age.
  
  
  CONCLUSIONS
  We observed a significant increase of anti-TG antibody in children with nontransient congenital hypothyroidism compared to healthy controls. Further study focusing pathogenetic role of anti-TG antibody in nontransient congenital hypothyroidism is necessary. Furthermore, the clinical significance in the course of congenital hypothyroidism need to be known.
authors.affiliation: Department of Pediatrcs, Kyungpook National University Children's Hospital, Daegu, Republic of Korea.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Cho
authors.affiliation: Department of Pediatrcs, Kyungpook National University Children's Hospital, Daegu, Republic of Korea.
authors.forename: Uk Hyun
authors.initials: UH
authors.lastname: Kim
authors.affiliation: Department of Pediatrcs, Kyungpook National University Children's Hospital, Daegu, Republic of Korea.
authors.forename: Byung Ho
authors.initials: BH
authors.lastname: Choi
authors.affiliation: Department of Pediatrcs, Kyungpook National University Children's Hospital, Daegu, Republic of Korea.
authors.forename: Cheol Woo
authors.initials: CW
authors.lastname: Ko
keywords: Anti-thyroglobulin antibody; Autoantibodies; Congenital hypothyroidism