title: Human papilloma virus and esophageal squamous cell carcinoma.
abstract: Human papillomavirus (HPV) has also been suggested as an etiology of esophageal squamous cell carcinoma (SCC). The aim of this study was to investigate the prevalence of HPV infection in esophageal SCCs in our region with strict contamination control to prevent false positive results. Thirty cases of esophageal squamous cell carcinomas were chosen by simple random selection in a period of two years. PCR for target sequence of HPV L1 gene was performed on nucleic acid extracted from samples by means of GP5+/GP6+ primers. All tissue samples in both case and control groups were negative for HPV-DNA. Although the number of cases in this study was limited, the contribution of HPV in the substantial number of esophageal SCCs in our region is unlikely.
authors.affiliation: Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. haerihay@sina.tums.ac.ir.
authors.forename: Hayedeh
authors.initials: H
authors.lastname: Haeri
authors.affiliation: Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. omid_mar@yahoo.com.
authors.forename: Omid
authors.initials: O
authors.lastname: Mardani
authors.affiliation: Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. asadiamo@sina.tums.ac.ir.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Asadi-Amoli
authors.affiliation: Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Cancer Research Center, Tehran University of Medical Sciences, Tehran Iran. shahsiah@yahoo.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Shahsiah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors