title: Ability of vitamin D receptor activator to prevent pulmonary congestion in advanced chronic kidney disease.
abstract: BACKGROUND
  Vitamin D deficiency is common among patients with chronic kidney disease (CKD). However, the benefits of vitamin D supplementation versus vitamin D receptor activator (VDRA) administration have yet to be established. Recently, an association between activated vitamin D and cardiovascular factors was reported. To evaluate the benefits of VDRA in advanced CKD, we analyzed the association between VDRA administration and the prevalence of pulmonary congestion.
  
  
  METHODS
  This retrospective, cross-sectional analysis included patients initiated on dialysis between October 2011 and September 2013 at 17 Japanese institutions. Data from 952 participants were analyzed using a multivariate logistic regression model and a linear regression model. We also analyzed subgroup data for groups classified by selection of peritoneal dialysis or hemodialysis.
  
  
  RESULTS
  Of the 952 participants, 303 patients received VDRA. VDRA administration was associated with a low prevalence of pulmonary congestion in the multivariate logistic regression model (odds ratio [OR], 0.64; 95 % confidence interval [CI], 0.44-0.94; P = 0.02). There was no significant association between VDRA administration and systolic blood pressure, diastolic blood pressure, or pulse pressure. Subgroup analysis revealed a tendency that VDRA administration was associated with low prevalence of pulmonary congestion in both groups.
  
  
  CONCLUSIONS
  In this study, VDRA administration was associated with a low prevalence of pulmonary congestion in patients initiated on dialysis. Appropriate VDRA administration may prevent pulmonary congestion.
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan. sueta.shinichi@gmail.com.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sueta
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Morozumi
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Takeda
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Horike
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Otsuka
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Hibiki
authors.initials: H
authors.lastname: Shinjo
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Murata
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Goto
authors.affiliation: Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan.
authors.forename: Daijo
authors.initials: D
authors.lastname: Inaguma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011654:Pulmonary Edema / Q000453:epidemiology* / Q000209:etiology; D018167:Receptors, Calcitriol / Q000819:agonists*; D012044:Regression Analysis; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy*
chemical_list: D018167:Receptors, Calcitriol
keywords: Chronic kidney disease; Congestive heart failure; Vitamin D receptor activator