title: Card-placing test in amnestic mild cognitive impairment and its neural correlates.
abstract: BACKGROUND
  [corrected] We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI).
  
  
  METHODS
  Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients.
  
  
  RESULTS
  The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus.
  
  
  CONCLUSIONS
  This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI.
authors.forename: Seong-Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Young-Sil
authors.initials: YS
authors.lastname: An
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Lim
authors.affiliation: Department of Neurology, School of Medicine, Ajou University, 5 San, Woncheon-dong, Yongtong-gu, Suwon-si, Kyunggi-do 442-749, Republic of Korea. symoon.bv@gmail.com.
authors.forename: So Young
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000367:Age Factors; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001923:Brain Chemistry / Q000502:physiology; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000523:psychology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012959:Socioeconomic Factors
chemical_list: D019788:Fluorodeoxyglucose F18