title: Behçet's disease diagnosed after acute HIV infection: viral replication activating underlying autoimmunity?
abstract: Behçet's disease is an autoimmune systemic vasculitis that can occur after exposure to infectious agents. Behçet's disease also has been associated with HIV infection, including de novo development of this condition during chronic HIV infection and resolution of Behçet's disease symptoms following initiation of antiretroviral therapy. We describe a patient who presented with systemic vasculitis with skin and mucous membrane ulcerations in the setting of acute HIV infection, who was eventually diagnosed with Behçet's disease, demonstrating a possible link between acute HIV infection, immune activation and development of autoimmunity.
authors.affiliation: HIV Services, Family Medicine Residency of Idaho, Boise, ID, USA clay.roscoe@fmridaho.org.
authors.forename: Clay
authors.initials: C
authors.lastname: Roscoe
authors.affiliation: Partnership Health Center, Family Medicine Residency of Western Montana, Montana, MT, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Kinney
authors.affiliation: Kootenai Health Family Medicine Couer d'Alene Residency, Couer d'Alene, ID, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Gilles
authors.affiliation: HIV Services, Family Medicine Residency of Idaho, Boise, ID, USA.
authors.forename: Sky
authors.initials: S
authors.lastname: Blue
mesh_terms: D000328:Adult; D015551:Autoimmunity; D001528:Behcet Syndrome / Q000150:complications / Q000175:diagnosis*; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1; D006801:Humans; D012883:Skin Ulcer / Q000473:pathology; D014657:Vasculitis / Q000209:etiology; D014779:Virus Replication
keywords: AIDS; Behçet's disease; HIV; acute HIV infection; antiretroviral therapy