title: A biotin-guided fluorescent-peptide drug delivery system for cancer treatment.
abstract: Herein, we present a fluorescent-peptide drug delivery system composed of biotin-naphthalimide-HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Taeyoung
authors.initials: T
authors.lastname: Kim
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Jeon
authors.forename: Hoa Thi
authors.initials: HT
authors.lastname: Le
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Kim
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001710:Biotin / Q000008:administration & dosage* / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods*; D005456:Fluorescent Dyes / Q000008:administration & dosage* / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D010455:Peptides; D001710:Biotin