title: A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease.
abstract: Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer's disease (AD) within 2-3 years with >90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and periphery. We show that a 24-week nutritional intervention in drug-naïve patients with very mild to mild AD significantly increased 5 of the 7 measured biomarker phosphatidylcholine species. By providing nutrients which normally rate-limit phospholipid synthesis, this nutritional intervention could be useful in asymptomatic subjects with a plasma lipid biomarker profile prognostic of AD.
authors.affiliation: Department of Neurodegeneration and Neurobiology, Deutsches Institut für Demenzprävention, Saarland University, Homburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Hartmann
authors.affiliation: Nutricia Research, Utrecht, The Netherlands.
authors.forename: Nick
authors.initials: N
authors.lastname: van Wijk
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Wurtman
authors.affiliation: Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: Marcel G M
authors.initials: MG
authors.lastname: Olde Rikkert
authors.affiliation: Nutricia Research, Utrecht, The Netherlands.
authors.forename: John W C
authors.initials: JW
authors.lastname: Sijben
authors.affiliation: Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.affiliation: Department of Internal and Geriatrics Medicine, Hôpitaux de Toulouse, Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.affiliation: Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000178:diet therapy*; D000704:Analysis of Variance; D060825:Cognitive Dysfunction / Q000097:blood / Q000178:diet therapy; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000097:blood*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D010743:Phospholipids
keywords: Alzheimer's disease; membranes; nutritional intervention; phosphatidylcholine; plasma phospholipids; prognostic biomarkers; synaptic dysfunction