title: Common ground: stem cell approaches find shared pathways underlying ALS.
abstract: The development of curative therapies for genetically complex diseases such as ALS has been delayed by the lack of relevant disease models. Recent advances using induced-pluripotent-stem-cell-derived motoneurons from patients harboring distinct ALS mutations have recapitulated essential disease features and have identified some common pathways driving disease pathogenesis.
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Independencia 1027, Chile; Neurounion Biomedical Foundation, Santiago, Chile. Electronic address: soledad.matus@neurounion.com.
authors.forename: Soledad
authors.initials: S
authors.lastname: Matus
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Independencia 1027, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Santiago, Chile.
authors.forename: Danilo B
authors.initials: DB
authors.lastname: Medinas
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Independencia 1027, Chile; Neurounion Biomedical Foundation, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Santiago, Chile. Electronic address: chetz@med.uchile.cl.
authors.forename: Claudio
authors.initials: C
authors.lastname: Hetz