title: Targeted highly sensitive detection/eradication of multi-drug resistant Salmonella DT104 through gold nanoparticle-SWCNT bioconjugated nanohybrids.
abstract: Monoclonal antibody-conjugated sphere-shaped gold nanoparticles were combined with single-walled carbon nanotubes (SWCNTs) to create a nanohybrid system to selectively detect and eradicate multiple drug resistant Salmonella (MDRS) typhimurium DT104 bacteria. The Raman signal intensity from Rhodamine 6G (Rh6G) modified monoclonal AC04 antibody SWCNTs-gold nanoparticle (SWCNT-GNPs) hybrid provided a SERS enhancement by several orders of magnitude to detect the MDRS bacteria over the GNP system. A targeted photothermolysis experiment using 670 nm light at 2 W cm(-2) for 15 min, resulted in selective and irreparable damage to more than 99% Salmonella DT104 at the concentration of 10(5) CFU mL(-1). In comparison to solely SWCNTs or GNPs, our SWCNT-GNPs nanohybrids have also shown a better photothermal efficiency.
authors.affiliation: Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA. ashton.t.hamme@jsums.edu.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lin
authors.forename: Ashton T
authors.initials: AT
authors.lastname: Hamme Ii
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010782:Photolysis; D010789:Phototherapy; D012235:Rhodamines / Q000008:administration & dosage* / Q000627:therapeutic use; D012480:Salmonella Infections / Q000382:microbiology / Q000628:therapy; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification* / Q000528:radiation effects; D013059:Spectrum Analysis, Raman
chemical_list: D000911:Antibodies, Monoclonal; D037742:Nanotubes, Carbon; D012235:Rhodamines; C026188:rhodamine 6G; D006046:Gold