title: Application of international consensus diagnostic criteria to an Italian series of autoimmune pancreatitis.
abstract: BACKGROUND
  International consensus diagnostic criteria (ICDC) have been proposed to classify autoimmune pancreatitis (AIP) in type 1, type 2, or not otherwise specified.
  
  
  OBJECTIVE
  Aim was to apply the ICDC to an Italian series of patients to evaluate the incidence and clinical profiles among different subtypes of AIP.
  
  
  METHODS
  we re-evaluated and classified 92 patients diagnosed by Verona criteria, according to the ICDC.
  
  
  RESULTS
  Out of 92 patients, 59 (64%) were diagnosed as type 1, 17 (18%) as type 2, and 15 (16%) as not otherwise specified according to the ICDC. A significant difference between type 1 and type 2 were found for age (54.5 ± 14.5 vs. 34.4 ± 13.9 respectively; p < 0.0001), male sex (76 vs. 47%; p = 0.007), jaundice (66 vs. 18%; p = 0.002) and acute pancreatitis (9 vs. 47%; p < 0.0001), elevated serum IgG4 levels (85 vs. 7%; p < 0.0001), inflammatory bowel disease (8 vs. 82%; < 0.0001), and relapse of the disease (34 vs. 6%; p = 0.058). Imaging and response to steroids in the not-otherwise-specified group were similar to type 1 and 2.
  
  
  CONCLUSIONS
  Type 1 has a different clinical profile from type 2 autoimmune pancreatitis. The not-otherwise-specified group has peculiar clinical features which are shared both with type 1 or type 2 groups.
authors.affiliation: Kansai Medical University, Osaka, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ikeura
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manfredi
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zamboni
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Negrelli
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Capelli
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Amodio
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Caliò
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Colletta
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Gabbrielli
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Benini
authors.affiliation: Kansai Medical University, Osaka, Japan.
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Okazaki
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Italo
authors.initials: I
authors.lastname: Vantini
authors.affiliation: University of Verona, Verona, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Frulloni
keywords: Autoimmunity; diagnosis; imaging; pancreatic diseases; pathology