title: Human stem cells for modeling heart disease and for drug discovery.
abstract: A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.
authors.affiliation: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Matsa
authors.affiliation: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Burridge
authors.affiliation: Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. joewu@stanford.edu.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D055808:Drug Discovery; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D008955:Models, Cardiovascular; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014945:Wound Healing