title: The dual role of ERK signaling in the apoptosis of neurons.
abstract: The extracellular signal-regulated kinase (ERK) signaling pathway participates in various cell responses, such as proliferation, migration, differentiation and death. In neuronal apoptosis, the ERK pathway has been shown to have a dual role. Although the majority of studies have demonstrated the ERK pathway to have an anti-apoptotic role in neurons, pro-apoptosis induced by ERK signaling, has also been observed. The different effects of the ERK pathway may be due to the different kinds of neurons used in these studies, stimulus, interplay with other MAPK pathways and maybe other as yet unclear factors. In this review, we will summarize the role of the ERK signaling pathway in the apoptosis of neurons.
authors.affiliation: School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
authors.forename: Hongmin
authors.initials: H
authors.lastname: Liu
authors.affiliation: School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Yang
authors.affiliation: School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
authors.forename: Tai
authors.initials: T
authors.lastname: Yang
authors.affiliation: School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
authors.forename: Guoping
authors.initials: G
authors.lastname: He
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D010766:Phosphorylation
chemical_list: D048049:Extracellular Signal-Regulated MAP Kinases; D020928:Mitogen-Activated Protein Kinases; D002118:Calcium