title: Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats.
abstract: The aim of the current study is to examine the improving effect of Sasa borealis stem (SBS) extract extracts on high-fat diet (HFD)-induced hepatic steatosis in rats. To determine the hepatoprotective effect of SBS, we fed rats a normal regular diet (ND), HFD, and HFD supplemented with 150 mg/kg body weight (BW) SBS extracts for five weeks. We found that the body weight and liver weight of rats in the HFD + SBS group were significantly lower than those in the HFD group. Significantly lower serum total cholesterol (TC) and triglyceride (TG) concentrations were observed in the SBS-supplemented group compared with the HFD group. We also found that the HFD supplemented with SBS group showed dramatically reduced hepatic lipid accumulation compared to the HFD alone group, and administration of SBS resulted in dramatic suppression of TG, TC in the HFD-induced fatty liver. In liver gene expression within the SBS treated group, PPARα was significantly increased and SREBP-1c was significantly suppressed. SBS induced a significant decrease in the hepatic mRNA levels of PPARγ, FAS, ACC1, and DGAT2. In conclusion, SBS improved cholesterol metabolism, decreased lipogenesis, and increased lipid oxidation in HFD-induced hepatic steatosis in rats, implying a potential application in treatment of non-alcoholic fatty liver disease.
authors.affiliation: Institute of Agriculture and Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea. yunosong0805@gmail.com.
authors.forename: Yuno
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Foods and Nutrition, Gyeongsang National University, Jinju 660-701, Korea. bodry96@hanmail.net.
authors.forename: Soo-Jung
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Institute of Agriculture and Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea. sunhee5321@naver.com.
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Jang
authors.affiliation: Department of Animal Science & Biotechnology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea. hee71111@nate.com.
authors.forename: Ji Hee
authors.initials: JH
authors.lastname: Ha
authors.affiliation: Department of Animal Science & Biotechnology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea. pigsong@gntech.ac.kr.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Song
authors.affiliation: Animal Genetic Resources Station, National Institute of Animal Science, RDA, Namwon 590-832, Korea. kog4556@korea.kr.
authors.forename: Yeoung-Gyu
authors.initials: YG
authors.lastname: Ko
authors.affiliation: Department of Environmental Health Science, New York Medical College, Valhalla, NY 10595, USA. HongDuck_Kim@nymc.edu.
authors.forename: Hong-Duck
authors.initials: HD
authors.lastname: Kim
authors.affiliation: Institute of Agriculture and Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea. wongimin@gnu.ac.kr.
authors.forename: Wongi
authors.initials: W
authors.lastname: Min
authors.affiliation: Department of Bioindustry, Daegu University, Gyungsan 712-714, Korea. whitenightt@hanmail.net.
authors.forename: Suk Nam
authors.initials: SN
authors.lastname: Kang
authors.affiliation: Institute of Agriculture and Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea. jaehcho@gnu.ac.kr.
authors.forename: Jae-Hyeon
authors.initials: JH
authors.lastname: Cho
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D005234:Fatty Liver / Q000139:chemically induced / Q000517:prevention & control*; D005419:Flavonoids / Q000737:chemistry; D008099:Liver / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000139:chemically induced*; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031787:Sasa / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol