title: Mechanistic insights into the substrate recognition of PPO: toward the rational design of effective inhibitors.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, P.R. China.
authors.forename: Ge-Fei
authors.initials: GF
authors.lastname: Hao
authors.forename: Chang-Guo
authors.initials: CG
authors.lastname: Zhan
authors.forename: Guang-Fu
authors.initials: GF
authors.lastname: Yang
mesh_terms: D015195:Drug Design; D005420:Flavoproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D046350:Porphyria, Variegate / Q000188:drug therapy* / Q000201:enzymology*; D050768:Protoporphyrinogen Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D005420:Flavoproteins; D024101:Mitochondrial Proteins; C493978:PPOX protein, human; D050768:Protoporphyrinogen Oxidase
keywords: agricultural herbicide; inhibitor design; photodynamic therapy; resistance; substrate recognition; variegated porphyria