title: Acute kidney injury associated with Plasmodium malariae infection.
abstract: According to current estimates, Plasmodium malariae is not very common in Senegal, as more than 98% of malaria cases are suspected to be due to Plasmodium falciparum. However, it is possible that other malarial species are being under-reported or misdiagnosed. This is a report of a case of P. malariae in a 30-year-old man previously hospitalized with acute kidney injury after treatment with quinine and re-hospitalized three months later. He was diagnosed with renal cortical necrosis post malaria treatment. Plasmodium malariae was identified with light microscope and confirmed using species-specific small-subunit rRNA (ssrRNA) amplification.The patient was treated for malaria with intravenous quinine for seven days, followed by three days of oral treatment; the bacterial infection was treated using ceftriaxone during the first hospitalization and ciprofloxacin associated with ceftriaxone the second time. He also had four rounds of dialysis after which he partially recovered the renal function. Given the complications that can be caused by P. malariae infection, it should be systematically looked for, even if the predominant species is P. falciparum in Senegal.
authors.affiliation: Laboratory of Parasitology-Mycology LeDantec Hospital, 30 Pasteur Avenue, Dakar, Senegal. asbadiane@gmail.com.
authors.forename: Aida S
authors.initials: AS
authors.lastname: Badiane
authors.forename: Khadim
authors.initials: K
authors.lastname: Diongue
authors.forename: Seydou
authors.initials: S
authors.lastname: Diallo
authors.forename: Aliou A
authors.initials: AA
authors.lastname: Ndongo
authors.forename: Cyrille K
authors.initials: CK
authors.lastname: Diedhiou
authors.forename: Awa B
authors.initials: AB
authors.lastname: Deme
authors.forename: Diallo
authors.initials: D
authors.lastname: Ma
authors.forename: Mouhamadou
authors.initials: M
authors.lastname: Ndiaye
authors.forename: Mame C
authors.initials: MC
authors.lastname: Seck
authors.forename: Therese
authors.initials: T
authors.lastname: Dieng
authors.forename: Omar
authors.initials: O
authors.lastname: Ndir
authors.forename: Souleymane
authors.initials: S
authors.lastname: Mboup
authors.forename: Daouda
authors.initials: D
authors.lastname: Ndiaye
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000473:pathology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000962:Antimalarials / Q000627:therapeutic use; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy; D002443:Ceftriaxone / Q000627:therapeutic use; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D008853:Microscopy; D021141:Nucleic Acid Amplification Techniques; D010965:Plasmodium malariae / Q000302:isolation & purification*; D011803:Quinine / Q000627:therapeutic use; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D006435:Renal Dialysis; D012675:Senegal; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D012337:RNA, Ribosomal, 18S; D002443:Ceftriaxone; D011803:Quinine