title: Modulation of adult hippocampal neurogenesis by early-life environmental challenges triggering immune activation.
abstract: The immune system plays an important role in the communication between the human body and the environment, in early development as well as in adulthood. Per se, research has shown that factors such as maternal stress and nutrition as well as maternal infections can activate the immune system in the infant. A rising number of research studies have shown that activation of the immune system in early life can augment the risk of some psychiatric disorders in adulthood, such as schizophrenia and depression. The mechanisms of such a developmental programming effect are unknown; however some preliminary evidence is emerging in the literature, which suggests that adult hippocampal neurogenesis may be involved. A growing number of studies have shown that pre- and postnatal exposure to an inflammatory stimulus can modulate the number of proliferating and differentiating neural progenitors in the adult hippocampus, and this can have an effect on behaviours of relevance to psychiatric disorders. This review provides a summary of these studies and highlights the evidence supporting a neurogenic hypothesis of immune developmental programming.
authors.affiliation: Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK ; Department of Psychological Medicine, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK ; MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, 16 De Crespigny Park, London SE5 8AF, UK.
authors.forename: Ksenia
authors.identifier: 0000-0003-4363-3732
authors.initials: K
authors.lastname: Musaelyan
authors.affiliation: Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK ; Department of Psychological Medicine, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Egeland
authors.affiliation: MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, 16 De Crespigny Park, London SE5 8AF, UK.
authors.forename: Cathy
authors.identifier: 0000-0001-7318-3352
authors.initials: C
authors.lastname: Fernandes
authors.affiliation: Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK ; Department of Psychological Medicine, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Carmine M
authors.initials: CM
authors.lastname: Pariante
authors.affiliation: Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK ; Department of Psychological Medicine, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Zunszain
authors.affiliation: Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Sandrine
authors.identifier: 0000-0003-1260-8083
authors.initials: S
authors.lastname: Thuret
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006624:Hippocampus / Q000254:growth & development* / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007231:Infant, Newborn; D055495:Neurogenesis / Q000502:physiology*