title: Pharmacological inhibition of bromodomain-containing proteins in inflammation.
abstract: Inflammation is associated with the activation of genes that contribute to immune defense and tissue repair. The bromodomain-containing proteins of the BET family, which recognize histone lysine acetylation, play a key role in the transcriptional control of inflammatory genes. Inhibition of BET proteins by the small-molecule inhibitor I-BET affects the expression of a particular subset of inflammatory genes-namely, ones that follow an "analog-like," but not "digital-like" activation pattern. This ability of I-BET to target genes based on the dynamic pattern of their activation may facilitate the further development of anti-inflammatory treatment protocols that are tuned to the individual or to disease-specific patterns of gene expression.
authors.affiliation: Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, New York 10065.
authors.forename: Uwe
authors.initials: U
authors.lastname: Schaefer
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy*; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D011506:Proteins