title: Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa.
abstract: BACKGROUND
  Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease affecting skin that bears apocrine glands. Only anecdotal reports and a few small studies have demonstrated a possible association between HS and depression, but these studies were uncontrolled or were based on small sample sizes. To the best of our knowledge, the association between HS and other psychiatric disorders has never been investigated.
  
  
  OBJECTIVE
  To investigate the association between HS and psychiatric disorders: depression, anxiety, psychoses, schizophrenia and bipolar disorder.
  
  
  METHODS
  A cross-sectional study was conducted utilizing the database of Clalit Health Services (over 4,100,000 patients). Case patients were defined as having HS when diagnosed by a dermatologist. Control patients without HS were age and gender matched in a 2 : 1 manner. The proportions of patients with psychiatric diseases were compared between patients with and without HS. The association between HS and psychiatric diseases was assessed in multivariate models using logistic regression analyses.
  
  
  RESULTS
  The study included 3207 patients with HS and 6412 age- and gender-matched controls. Depression was diagnosed in 5.9% of patients with HS vs. 3.5% of patients without HS (P < 0.001). Anxiety was diagnosed in 3.9% of patients with HS vs. 2.4% of patients without HS (P < 0.001). These associations were significant after controlling for the confounders age and gender (Depression: OR = 1.7, 95% CI: 1.4-2.1; Anxiety: OR = 1.7, 95% CI: 1.3-2.1).
  
  
  CONCLUSIONS
  Hidradenitis suppurativa was associated with depression and anxiety. Dermatologists treating patients with HS should be aware of this important association.
authors.affiliation: Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel.|Faculty of Health Sciences, Division of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Shavit
authors.affiliation: Hospital Division, Central Headquarters, Clalit Health Services, Tel Aviv, Israel.|Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Dreiher
authors.affiliation: Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: T
authors.initials: T
authors.lastname: Freud
authors.affiliation: Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel.|Faculty of Health Sciences, Division of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Halevy
authors.affiliation: Chief Physician Office, Central Headquarters, Clalit Health Services, Tel Aviv, Israel.|Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Vinker
authors.affiliation: Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.|Chief Physician Office, Central Headquarters, Clalit Health Services, Tel Aviv, Israel.
authors.forename: A D
authors.initials: AD
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D017497:Hidradenitis Suppurativa / Q000150:complications* / Q000523:psychology; D006801:Humans; D007223:Infant; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D008875:Middle Aged; D055815:Young Adult