title: A distinct phenotype of childhood leukodystrophy presenting as absence seizure.
abstract: Leukoencephalopathy refers to any disease of the white matter including hereditary as well as acquired and toxic causes. Inherited leukodystrophies are diseases of myelin including abnormal myelin development, hypomyelination, or degeneration of myelin. We report a 6-year old female who presented with absence seizure at the age of 4 years. Cerebral magnetic resonance imaging (MRI) of the brain showed bilateral periventricular confluent high signal intensity. The seizure responded to anticonvulsant therapy, and the clinical course was characterized by normal development and neurological examination.
authors.affiliation: Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
authors.forename: Imad Mohammad
authors.initials: IM
authors.lastname: Dweikat
authors.affiliation: Department of Pediatrics, Al-Makassed Islamic Charitable Society Hospital, Jerusalem, Israel.
authors.forename: Nadera
authors.initials: N
authors.lastname: Damsah
authors.affiliation: Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
authors.forename: Reham
authors.initials: R
authors.lastname: Khalaf
keywords: Absence seizure; demyelinating; leukodystrophy; white matter