title: Treatment of nodular facial angiofibromas in tuberous sclerosis, using ultrapulse carbon dioxide laser.
abstract: Tuberous sclerosis (TS) is a genodermatosis characterized by facial angiofibromas (FAs). These tumours cause aesthetic disfigurement and obstruction of vision, and haemorrhage when traumatized, which can lead to emotional distress and relationship difficulties. We report the case of a 35-year-old patient with extensive TS-associated FAs that were treated with an ultrapulse carbon dioxide laser (UPCDL). UPCDL laser seems to be a easy, useful and convenient tool for the treatment of nodular FAs, which provides good aesthetic results, and a positive response from patients, who report high levels of satisfaction with the results. Minimal recurrence of the tumours occurred during long-term follow-up, and these were successfully treated with UPCDL. It is not yet possible to correct the genetic alterations underlying TS, but UPCDL treatment is a convenient tool to improve the facial appearance of patients with severe FAs.
authors.affiliation: Unit of Dermatology and Cosmetology, San Raffaele Scientific University Institute, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Biondo
authors.forename: S
authors.initials: S
authors.lastname: Greco
authors.forename: L
authors.initials: L
authors.lastname: Mavilia
authors.forename: S R
authors.initials: SR
authors.lastname: Mercuri
mesh_terms: D000328:Adult; D018322:Angiofibroma / Q000601:surgery*; D002245:Carbon Dioxide; D005153:Facial Neoplasms / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D012878:Skin Neoplasms / Q000601:surgery*; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications*
chemical_list: D002245:Carbon Dioxide