title: Visualization and treatment of subclinical actinic keratoses with topical imiquimod 5% cream: an observational study.
abstract: BACKGROUND
  Imiquimod 5% is licensed for the treatment of external genital warts, superficial basal cell carcinoma, and actinic keratosis (AK) and is being used experimentally in various other dermato-oncological conditions.
  
  
  OBJECTIVE
  This observational study shall show that nonmelanoma skin cancer can be detected at its earliest subclinical stage by its reaction with imiquimod and can be cleared by finishing the course of treatment.
  
  
  METHODS
  In this single arm trial 15 patients with chronically sun-exposed skin who had no clinical evidence of AK were treated with 5% imiquimod cream on the face or scalp for 4 weeks three times per week.
  
  
  RESULTS
  During treatment, all patients developed multiple areas with mild to moderate inflammatory skin reactions, such as erythema, induration, and scaling. Biopsies obtained from 12 patients prior to treatment revealed no malignancies. However, in cases with more pronounced inflammation during treatment, targeted biopsies indicated very early malignant alterations.
  
  
  CONCLUSIONS
  Topical imiquimod treatment of chronically sun-exposed skin without overt clinical signs of AK is able to detect subclinical actinic keratoses (SAK) and to completely clear the lesions, even before they can be clinically diagnosed as AK. In such patients, imiquimod might be able to prevent the evolution of SCC.
authors.affiliation: Department of Dermatology, Medical University Graz, Auenbruggerplatz 89, 8036 Graz, Austria.
authors.forename: Daisy
authors.initials: D
authors.lastname: Kopera
authors.affiliation: Department of Dermatology, Medical University Graz, Auenbruggerplatz 89, 8036 Graz, Austria.
authors.forename: Helmut
authors.initials: H
authors.lastname: Kerl
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D055623:Keratosis, Actinic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D063465:Skin Cream / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod