title: Inhalation carcinogenicity of dichloromethane in rats and mice.
abstract: The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar-alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association , Kanagawa , Japan.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Aiso
authors.forename: Makoto
authors.initials: M
authors.lastname: Take
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kasai
authors.forename: Hideki
authors.initials: H
authors.lastname: Senoh
authors.forename: Yumi
authors.initials: Y
authors.lastname: Umeda
authors.forename: Michiharu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology; D008752:Methylene Chloride / Q000633:toxicity*; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced* / Q000473:pathology; D011916:Rats, Inbred F344; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D002273:Carcinogens; D008752:Methylene Chloride
keywords: Carcinogenicity; dichloromethane; inhalation; mouse; rat