title: Development of (166)Ho-phytate Complex for Radiosynovectomy.
abstract: BACKGROUND
  (66)Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5 × 10(13) n.cm(-2).s(-1)).
  
  
  METHODS
  (166)Ho-holmium chloride (185 MBq) was used successfully for preparation of (166)Ho-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution (60 μCi/100 μl) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days.
  
  
  RESULTS
  Approximately all of the injected dose had remained in the injection site 2 days after injection.
  
  
  CONCLUSIONS
  The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.
authors.affiliation: Radiopharmaceutical Research and Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 14155-1339.
authors.forename: Amir R
authors.initials: AR
authors.lastname: Jalilian
authors.affiliation: Faculty of Nuclear Engineering, Shahid Beheshti University, P.O. Box: 19839-63113, Tehran, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Anvari
authors.affiliation: Radiopharmaceutical Research and Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 14155-1339.
authors.forename: Ali
authors.initials: A
authors.lastname: Bahrami-Samani
authors.affiliation: Radiopharmaceutical Research and Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 14155-1339.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mazidi
authors.affiliation: Radiopharmaceutical Research and Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 14155-1339.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghannadi-Maragheh
keywords: Biodistribution; Holmium-166; Phytate; Radiosynovectomy; SPECT