title: [Inflammasomes in human diseases].
abstract: The understanding of the innate immunity, the first line of the host defence, was significantly modified following the sequential discovery of innate immune receptors such as the Toll-like receptors (TLRs) and the NOD-like receptors (NLRs). In response to recognition of microbial patterns or danger signals, some NLRs assemble a multimolecular platform termed as the inflammasome. Inflammasome assembly leads to the activation of the proinflammatory caspase-1. Consequently, an inflammatory immune response is mounted along with a programmed cell death, called pyroptosis. This review summarizes recent advances in the knowledge of the inflammasome and its role in auto-inflammatory diseases, autoimmune diseases, and most common metabolic, cardiovascular or rheumatic diseases.
authors.affiliation: Service de médecine interne, CHU de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; Centre international de recherche en infectiologie, Inserm U1111, CNRS UMR5308, université Lyon-1, ENS de Lyon, 21, avenue Tony-Garnier, 69365 Lyon, France; Département de biochimie, université de Lausanne, 155, chemin des Boveresses, 1066 Epalinges, Suisse; Université Claude-Bernard - Lyon-1, 69007 Lyon, France. Electronic address: yvanjamilloux@hotmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Jamilloux
authors.affiliation: Service de médecine interne, CHU de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; Université Claude-Bernard - Lyon-1, 69007 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Sève
authors.affiliation: Centre international de recherche en infectiologie, Inserm U1111, CNRS UMR5308, université Lyon-1, ENS de Lyon, 21, avenue Tony-Garnier, 69365 Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Henry
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016207:Cytokines; D051192:Receptors, Pattern Recognition
keywords: Auto-inflammatory diseases; Caspase-1; IL-1β; Inflammasome; Maladies auto-inflammatoires; Pyroptose; Pyroptosis