title: Role of low- and high-frequency oscillations in the human hippocampus for encoding environmental novelty during a spatial navigation task.
abstract: The hippocampus plays a key role in the encoding and retrieval of information related to novel environments during spatial navigation. However, the neural basis for these processes in the human hippocampus remains unknown because it is difficult to directly measure neural signals in the human hippocampus. This study investigated hippocampal neural oscillations involved in encoding novel environments during spatial navigation in a virtual environment. Seven epileptic patients with implanted intracranial hippocampal depth electrodes performed three sessions of virtual environment navigation. Each session consisted of a navigation task and a location-recall task. The navigation task consisted of eight blocks, and in each block, the participant navigated to the location of four different objects and was instructed to remember the location of the objects. After the eight blocks were completed, a location-recall task was performed for each of the four objects. Intracranial electroencephalography data were monitored during the navigation tasks. Theta (5-8 Hz) and delta (1-4 Hz) oscillations were lower in the first block (novel environment) than in the eighth block (familiar environment) of the navigation task, and significantly increased from block one to block eight. By contrast, low-gamma (31-50 Hz) oscillations were higher in the first block than in the eighth block of the navigation task, and significantly decreased from block one to block eight. Comparison of sessions with high recall performance (low error between identified and actual object location) and low recall performance revealed that high-gamma (51-100 Hz) oscillations significantly decreased from block one to block eight only in sessions with high recall performance. These findings suggest that delta, theta, and low-gamma oscillations were associated with encoding of environmental novelty and high-gamma oscillations were important for the successful encoding of environmental novelty.
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Jinsick
authors.initials: J
authors.lastname: Park
authors.forename: Hojong
authors.initials: H
authors.lastname: Lee
authors.forename: Taekyung
authors.initials: T
authors.lastname: Kim
authors.forename: Ga Young
authors.initials: GY
authors.lastname: Park
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Lee
authors.forename: Seunghee
authors.initials: S
authors.lastname: Baek
authors.forename: Jeonghun
authors.initials: J
authors.lastname: Ku
authors.forename: In Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
authors.forename: Dong Pyo
authors.initials: DP
authors.lastname: Jang
authors.forename: Joong Koo
authors.initials: JK
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D058256:Brain Waves; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009483:Neuropsychological Tests; D021641:Recognition, Psychology / Q000502:physiology; D065854:Spatial Navigation / Q000502:physiology*
keywords: environmental novelty; high-frequency oscillations; hippocampus; intracranial electro-encephalography; low-frequency oscillations