title: Copper-catalyzed synthesis of α-trifluoromethylthio-substituted ketones.
abstract: The CF3S-substituted moiety serves as an important structural element in many bioactive molecules. A versatile copper catalyst that allowed for trifluoromethylthiolation of primary and secondary α-bromoketones is described. The reaction with readily available elemental sulfur and CF3SiMe3 afforded a broad scope and moderate to good yields of α-trifluoromethylthio-substituted ketones. This procedure represents a very operationally simple yet powerful strategy for the synthesis of α-trifluoromethylthio-substituted ketones, a useful and versatile class of synthetic synthons.
authors.affiliation: Department of Chemistry, Fuzhou University , Fuzhou 350108, China.
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: He
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Lin
authors.forename: Mingguang
authors.initials: M
authors.lastname: Rong
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Weng
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: C523557:(trifluoromethyl)-trimethylsilane; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D014297:Trimethylsilyl Compounds; D003300:Copper