title: Copper-catalyzed enantioselective Friedel-Crafts alkylation of pyrrole with isatins.
abstract: The highly enantioselective Friedel-Crafts alkylation of pyrrole with isatins catalyzed by the tridentate Schiff base/Cu catalyst was developed. Hexafluoroisopropanol (HFIP) was used as a crucial additive to improve the enantioselectivity. In the case of N-unprotected isatins, an innovative substrate slow-releasing strategy was applied by virtue of a Henry/retro-Henry reaction.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China , Hefei, 230026, P. R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Li
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Guo
authors.forename: Kun
authors.initials: K
authors.lastname: Xu
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Hu
authors.forename: Zhenggen
authors.initials: Z
authors.lastname: Zha
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007510:Isatin / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism; D006845:Hydrocarbons, Fluorinated
chemical_list: D003300:Copper; D007211:Indoles; D007510:Isatin; D020005:Propanols; D011758:Pyrroles; C001337:hexafluoroisopropanol; D006845:Hydrocarbons, Fluorinated