title: [Glycoproteins, inherited diseases of platelets, and the role of platelets in wound healing].
abstract: Recognition that platelets have a glycocalyx rich in membrane glycoproteins prompted the discovery in France that inherited bleeding syndromes due to defects of platelet adhesion and aggregation were caused by deficiencies in major receptors at the platelet surface. Identification of the alpha IIb beta3 integrin prompted the development of powerful anti-thrombotic drugs that have gained worldwide use. Since these discoveries, the genetic causes of many other defects of platelet function and production have been elucidated, with the identification of an ADP receptor, P2 Y12, another widespread target for anti-thrombotic drugs. Discovery of the molecular basis of a rare disease of storage of biologically active proteins in platelet alpha-granules has been accompanied by the recognition of the roles of platelets in inflammation, the innate immune system and tissue repair, opening new avenues for therapeutic advances.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Nurden
authors.forename: Paquita
authors.initials: P
authors.lastname: Nurden
mesh_terms: D025861:Blood Coagulation Disorders, Inherited / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D001791:Blood Platelet Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000502:physiology; D010973:Platelet Adhesiveness / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000502:physiology*; D058921:Purinergic P2Y Receptor Antagonists / Q000494:pharmacology; D015398:Signal Transduction / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D016023:Integrins; D010980:Platelet Membrane Glycoproteins; D058921:Purinergic P2Y Receptor Antagonists