title: Peptide p160-coated silica nanoparticles applied in photodynamic therapy.
abstract: Peptide p160-conjugated mesoporous silica nanoparticles (MSN) were fabricated and loaded with photosensitizer hypocrellin B (HB). The results indicate that the nanocomposites have better selectivity for cancer cells and higher cytotoxicity in photodynamic therapy in vitro. The nanocomposites can be used as a novel candidate in photodynamic therapy. This may be a general and promising method to modify nanoparticles to improve their cell affinity.
authors.affiliation: National Center for Nanoscience and Technology, No. 11, Bei Yi Tiao Institution Beijing, 100190 (China), Fax: (+86) 10-82612629.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Anhe
authors.initials: A
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.forename: Gerald
authors.initials: G
authors.lastname: Brezesinski
authors.forename: Luru
authors.initials: L
authors.lastname: Dai
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D010455:Peptides / Q000737:chemistry*; D010569:Perylene / Q000008:administration & dosage / Q000031:analogs & derivatives; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011809:Quinones / Q000008:administration & dosage; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D010455:Peptides; D017319:Photosensitizing Agents; D011809:Quinones; D010569:Perylene; D012822:Silicon Dioxide; C064522:hypocrellin B
keywords: cancer; mesoporous silica; nanoparticles; peptides; photodynamic therapy