title: The probable auto-antigenic role of lipids (anti-ganglioside antibodies) in the pathogenesis of Alzheimer's disease.
abstract: We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched healthy individuals, using ELISA, to investigate the levels of IgM antibodies against GM1, GD1b, and GQ1b gangliosides and their possible correlation with clinical parameters (age, severity, and type of dementia). All the individuals that demonstrated positive titers of anti-ganglioside antibodies were demented patients whereas normal controls showed borderline or negative values. Significant correlation was revealed between IgM anti-GM1 and both the age of the patients and the severity of dementia. Most of the patients with increased IgM anti-GD1b titers suffered from AD.
authors.affiliation: Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Euphrosyni
authors.initials: E
authors.lastname: Koutsouraki
authors.affiliation: Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Hatzifilippou
authors.affiliation: Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Michmizos
authors.affiliation: Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Tania
authors.initials: T
authors.lastname: Banaki
authors.affiliation: Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Costa
authors.affiliation: Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Baloyannis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000888:Antibodies, Anti-Idiotypic; D005732:Gangliosides; C044203:anti-IgM; C039129:GQ1b ganglioside
keywords: Alzheimer's disease; dementia; gangliosides; lipids