title: Modeling in vivo corrosion of AZ31 as temporary biodegradable implants. Experimental validation in rats.
abstract: In this paper, two complementary approaches, mathematical modeling and experimental results are combined to identify variables that affect the in vivo biodegradation of magnesium implants. The in vivo corrosion behavior of AZ31 alloy proposed for temporary applications as fixation of bone fractures has been modeled solving the Laplace equation by finite element method (FEM). Bar-shaped AZ31 implants of 1mm diameter and 20mm length were inserted in Wistar rat femurs with and without a fracture. The presence of gas around AZ31 implants inside the femurs has been detected in situ at the epiphysis and in fractured areas by computerized tomography (CT). Examining some in vivo conditions, the model confirms that magnesium-alloy devices have different biodegradation behavior, depending on the thickness of electrolyte at the implantation site and can be used for predicting the biodegradation behavior.
authors.affiliation: Centro Nacional de Investigaciones Metalúrgicas, CENIM, CSIC, Avda. Gregorio del Amo 8, 28040, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Montoya
authors.affiliation: Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Iglesias
authors.affiliation: Centro Nacional de Investigaciones Metalúrgicas, CENIM, CSIC, Avda. Gregorio del Amo 8, 28040, Madrid, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Escudero
authors.affiliation: Centro Nacional de Investigaciones Metalúrgicas, CENIM, CSIC, Avda. Gregorio del Amo 8, 28040, Madrid, Spain. Electronic address: crisga@cenim.csic.es.
authors.forename: M C
authors.initials: MC
authors.lastname: García-Alonso
mesh_terms: D020341:Absorbable Implants / Q000662:veterinary*; D000497:Alloys / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D003343:Corrosion; D004573:Electrolytes / Q000737:chemistry; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000628:therapy; D005269:Femur / Q000000981:diagnostic imaging; D008962:Models, Theoretical; D051381:Rats; D017208:Rats, Wistar; D014057:Tomography, X-Ray Computed
chemical_list: D000497:Alloys; D004573:Electrolytes; C586533:Mg-Al-Zn-Mn-Si-Cu alloy
keywords: AZ31; Computerized tomography; Corrosion; Finite element method; In vivo; Modeling