title: Clinical and Histomorphometric Evaluation of Fresh Frozen Bone Allograft in Sinus Lift Surgery.
abstract: OBJECTIVE
  The aim of this prospective clinical study was to evaluate the clinical and histomorphometric data of newly formed bone tissue from fresh frozen human allograft in sinus lift surgery.
  
  
  METHODS
  Thirty-three sinus lift procedures were performed in 20 patients, divided into two groups. The control group (n = 8) received autogenous bone from the mandibular ramus, and the experimental group (n = 12) received fresh frozen bone (FFB) allograft in chips. After 6 months, 52 implants were placed and 50 biopsies were collected for histomorphometric analysis. Cone beam computed tomography scans were performed at preoperative, immediate postoperative, and delayed postoperative time intervals to assess the degree of graft volume loss.
  
  
  RESULTS
  There was no statistically significant difference between groups as regards degree of graft volume loss (p = .983), total bone area (p = .191), remaining particles (p = .348), and proportion of active osteoblasts (p = .867). There was a statistically significant difference in the vitality rate between the groups (p = .043). In both groups, all implants were clinically osseointegrated after 4 months.
  
  
  CONCLUSIONS
  FFB allograft was shown to be a feasible substitute for autogenous bone graft in sinus lift surgery.
authors.affiliation: Implantology Specialization Course, Fundação da Faculdade de Odontologia, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Tatiana Regina Ramos Nantes
authors.initials: TR
authors.lastname: de Castilho
authors.affiliation: Department of Prosthodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Tortamano
authors.affiliation: Department of Prosthodontics and Biomaterials, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
authors.forename: Juliana
authors.initials: J
authors.lastname: Marotti
authors.affiliation: Implantology Specialization Course, Fundação da Faculdade de Odontologia, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: José Carlos Silva
authors.initials: JC
authors.lastname: de Andrade
authors.affiliation: Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Israel
authors.initials: I
authors.lastname: Chilvarquer
authors.affiliation: Radiology Specialization Course, Associação Paulista dos Cirurgiões Dentistas-Jardim Paulista, São Paulo, Brazil.
authors.forename: Michel Eli Lipiec
authors.initials: ME
authors.lastname: Ximenez
authors.affiliation: Department of Pathology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Maria Teresa de Seixas
authors.initials: MT
authors.lastname: Alves
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts; D001706:Biopsy; D016025:Bone Transplantation / Q000379:methods*; D001938:Brazil; D054893:Cone-Beam Computed Tomography; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000637:transplantation; D008875:Middle Aged; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*; D016896:Treatment Outcome
keywords: bone graft; cone beam computed tomography; grafts; maxillary ridge augmentation