title: Treatment of choroidal neovascularisation secondary to membranoproliferative glomerulonephritis type II with intravitreal ranibizumab.
abstract: Membranoproliferative glomerulonephritis type II (MPGN II) is characterised by electron-dense deposits of complement components in the glomerular basement membrane and retinal pigment epithelium. Approximately, 10% of affected individuals develop serious ocular complications similar to age-related macular degeneration such as choroidal neovascularisation (CNV), which has been managed with photocoagulation or photodynamic therapy; however, these treatments can impact visual acuity. We report the case of a 42-year-old woman with MPGN II presenting with decreased visual acuity and paracentral scotoma in her left eye due to an extrafoveal choroidal neovascular membrane (growth of new vessels under the retina). The patient was successfully treated with intravitreal ranibizumab (Lucentis) with restoration of visual function. This case highlights the successful management of CNV secondary to MPGN II with the antivascular endothelial growth factor agent ranibizumab and emphasises the importance of early referral of patients with MPGN II who are reporting of visual 'distortion'.
authors.affiliation: Royal Victoria Hospital, Belfast, UK.
authors.forename: Donal
authors.initials: D
authors.lastname: McCullagh
authors.affiliation: Centre for Vision and Vascular Science, Queen's University, Belfast, UK.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Silvestri
authors.affiliation: Regional Nephrology Unit, Belfast City Hospital, Belfast, UK.
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Maxwell
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D001706:Biopsy; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D058449:Intravitreal Injections; D007668:Kidney / Q000473:pathology; D000069579:Ranibizumab; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab