title: Filling the holes in cystic kidney disease research.
abstract: Kidney disease is a significant medical and public health problem. The National Institute of Diabetes and Digestive and Kidney Diseases recently asked the community to identify research objectives, which, if addressed, could improve understanding of basic kidney function and aid in prevention, treatment, and reversal of kidney disease. The Kidney Research National Dialogue invited interested parties to submit, discuss, and prioritize ideas using an interactive website; 1600 participants posted more than 300 ideas covering all areas of kidney disease, including the cystic kidney diseases. Although much is known about the genetics and pathogenesis of cystic diseases, there remain challenges to our understanding of the fundamental mechanisms of cyst formation, what genes act as modifiers to cause variable responses in different people, and how to detect and monitor disease progression. This article summarizes key research questions for cystic kidney diseases.
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Guay-Woodford
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Henske
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Peter
authors.initials: P
authors.lastname: Igarashi
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Perrone
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Berenice
authors.initials: B
authors.lastname: Reed-Gitomer
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Stefan
authors.initials: S
authors.lastname: Somlo
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Vicente E
authors.initials: VE
authors.lastname: Torres
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Ketchum
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Star
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Flessner
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material. rr185i@nih.gov.
authors.forename: Rebekah S
authors.initials: RS
authors.lastname: Rasooly
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D004059:Diffusion of Innovation; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006292:Health Priorities / Q000639:trends; D006801:Humans; D009398:Nephrology / Q000639:trends*; D010641:Phenotype; D007690:Polycystic Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D005819:Genetic Markers
keywords: cilia; cysts; kidney disease; polycystic kidney disease