title: Dietary and lifestyle guidelines for the prevention of Alzheimer's disease.
abstract: Risk of developing Alzheimer's disease is increased by older age, genetic factors, and several medical risk factors. Studies have also suggested that dietary and lifestyle factors may influence risk, raising the possibility that preventive strategies may be effective. This body of research is incomplete. However, because the most scientifically supported lifestyle factors for Alzheimer's disease are known factors for cardiovascular diseases and diabetes, it is reasonable to provide preliminary guidance to help individuals who wish to reduce their risk. At the International Conference on Nutrition and the Brain, Washington, DC, July 19-20, 2013, speakers were asked to comment on possible guidelines for Alzheimer's disease prevention, with an aim of developing a set of practical, albeit preliminary, steps to be recommended to members of the public. From this discussion, 7 guidelines emerged related to healthful diet and exercise habits.
authors.affiliation: Department of Medicine, George Washington University School of Medicine, Washington, DC, USA; Physicians Committee for Responsible Medicine, Washington, DC, USA. Electronic address: nbarnard@pcrm.org.
authors.forename: Neal D
authors.initials: ND
authors.lastname: Barnard
authors.affiliation: Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
authors.forename: Ashley I
authors.initials: AI
authors.lastname: Bush
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Antonia
authors.initials: A
authors.lastname: Ceccarelli
authors.affiliation: Department of Medicine, George Washington University School of Medicine, Washington, DC, USA.
authors.forename: James
authors.initials: J
authors.lastname: Cooper
authors.affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
authors.forename: Celeste A
authors.initials: CA
authors.lastname: de Jager
authors.affiliation: Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Kirk I
authors.initials: KI
authors.lastname: Erickson
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Fraser
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Shelli
authors.initials: S
authors.lastname: Kesler
authors.affiliation: Physicians Committee for Responsible Medicine, Washington, DC, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Levin
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
authors.forename: Brendan
authors.initials: B
authors.lastname: Lucey
authors.affiliation: Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, IL, USA.
authors.forename: Martha Clare
authors.initials: MC
authors.lastname: Morris
authors.affiliation: Department of Neuroscience, AFaR-Fatebenefratelli Hospital "San Giovanni Calibita," Rome, Italy; Laboratory of Neurodegeneration, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Rome, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Squitti
mesh_terms: D000544:Alzheimer Disease / Q000517:prevention & control*; D014676:Diet, Vegetarian; D015444:Exercise / Q000502:physiology; D005227:Fatty Acids / Q000009:adverse effects; D006801:Humans; D008019:Life Style; D018673:Nutrition Policy; D012306:Risk; D044242:Trans Fatty Acids / Q000009:adverse effects; D014805:Vitamin B 12 / Q000008:administration & dosage; D014810:Vitamin E
chemical_list: D005227:Fatty Acids; D044242:Trans Fatty Acids; D014810:Vitamin E; D014805:Vitamin B 12
keywords: Alzheimer's disease; Copper; Dementia; Exercise; Iron; Nutrition; Prevention; Saturated fat; Trans fatty acids; Vitamin E