title: Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models.
abstract: OBJECTIVE
  To review studies performed in animal models that evaluated therapeutic interventions to inflammatory response and microcirculatory changes after cardiopulmonary bypass.
  
  
  METHODS
  It was used the search strategy ("Cardiopulmonary Bypass" (MeSH)) and ("Microcirculation" (MeSH) or "Inflammation" (MeSH) or "Inflammation Mediators" (MeSH)). Repeated results, human studies, non-English language articles, reviews and studies without control were excluded.
  
  
  RESULTS
  Blood filters, system miniaturization, specific primers regional perfusion, adequate flow and temperature and pharmacological therapies with anticoagulants, vasoactive drugs and anti-inflammatories reduced changes in microcirculation and inflammatory response.
  
  
  CONCLUSIONS
  Demonstrated efficacy in animal models establishes a perspective for evaluating these interventions in clinical practice.
authors.forename: Gabriel Romero
authors.initials: GR
authors.lastname: Liguori
authors.forename: Alexandre Fligelman
authors.initials: AF
authors.lastname: Kanas
authors.forename: Luiz Felipe Pinho
authors.initials: LF
authors.lastname: Moreira
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000379:methods; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D018836:Inflammation Mediators / Q000097:blood; D008833:Microcirculation / Q000502:physiology*; D023421:Models, Animal; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000628:therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators