title: Synthesis of 3-acylindoles by visible-light induced intramolecular oxidative cyclization of o-alkynylated N,N-dialkylamines.
abstract: A visible-light photoredox synthesis of 3-acylindoles through intramolecular oxidative cyclization of o-alkynylated N,N-dialkylamines is developed. The reaction proceeds effectively under mild reaction conditions using air as the oxidant, and only water is generated as a side product. A plausible mechanism involving the addition of α-amino alkyl radicals to alkynes, followed by C-O bond formation, is proposed.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University , 135 Xingang West Road, Guangzhou 510275, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Tiebo
authors.initials: T
authors.lastname: Xiao
authors.forename: Shengwei
authors.initials: S
authors.lastname: Xiong
authors.forename: Xichang
authors.initials: X
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014867:Water / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D007211:Indoles; D014867:Water