title: The effect of anesthesia type on stress hormone response: comparison of general versus epidural anesthesia.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of different types of anesthesia on stress hormones.
  
  
  METHODS
  The study was included 60 ASAI-II cases scheduled for major lower extremity surgery. The cases were randomized into 2 groups: The EA group was administered epidural anesthesia and the GA group was administered standard general anesthesia. In order to evaluate the surgical trauma - related stress response, CRP, TSH, cortisol, and fasting blood sugar(FBS) levels were measured preoperatively, 30 min after surgical incision, and 24 h post surgery.
  
  
  RESULTS
  Between-group comparisons; Preoperative values were not significantly different between the groups.( P > 0,05) Pulse rate and cortisol values significantly higher in general group at 30 min. ( P < 0,05), and the FBS values were significantly higher in the epidural group at 24 h.( P < 0,05) There were not found differences for other parameters at evaluation times.
  
  
  CONCLUSIONS
  No differences were observed between the two anesthesia methods, in terms of minimizing the stress response due to surgical trauma during major low extremity surgery.
authors.forename: K
authors.initials: K
authors.lastname: Kahveci
authors.forename: D
authors.initials: D
authors.lastname: Ornek
authors.affiliation: Departments of Anesthesiology, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Doger
authors.forename: G B
authors.initials: GB
authors.lastname: Aydin
authors.forename: M
authors.initials: M
authors.lastname: Aksoy
authors.forename: C
authors.initials: C
authors.lastname: Emre
authors.forename: A
authors.initials: A
authors.lastname: Deveci
authors.forename: M
authors.initials: M
authors.lastname: Bozkurt
authors.forename: G
authors.initials: G
authors.lastname: Ozgun
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural / Q000379:methods*; D000768:Anesthesia, General / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000502:physiology; D013972:Thyrotropin / Q000097:blood
chemical_list: D001786:Blood Glucose; D013972:Thyrotropin; D002097:C-Reactive Protein; D006854:Hydrocortisone