title: In vivo models for pathotyping and vaccine efficacy for swine influenza.
abstract: Swine influenza is a disease of the respiratory tract caused by influenza A virus (IAV). Experimental inoculation of pigs involves either aerosolization and inhalation of virus or the direct introduction of virus into the upper or lower respiratory tract. This chapter covers methods for experimental IAV infection of pigs and collection of specific samples to study the pathogenesis of swine influenza and vaccine efficacy.
authors.affiliation: Virus and Prion Research Unit, National Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, 1920 Dayton Avenue, Ames, IA, 50010, USA, kelly.lager@ars.usda.gov.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Lager
authors.forename: Amy L
authors.initials: AL
authors.lastname: Vincent
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology*; D007252:Influenza Vaccines / Q000276:immunology*; D009666:Nose / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000635:transmission; D010641:Phenotype; D013552:Swine / Q000821:virology*; D014132:Trachea / Q000821:virology
chemical_list: D007252:Influenza Vaccines