title: Narrow band imaging vs. high definition colonoscopy for detection of colorectal adenomas in patients with positive faecal occult blood test: a randomised trial.
abstract: BACKGROUND
  The impact of narrow band imaging in improving the adenoma detection rate in a screening scenario is still unclear.
  
  
  OBJECTIVE
  To evaluate whether narrow band imaging compared with high definition white light colonoscopy can enhance the adenoma detection rate during screening colonoscopy.
  
  
  METHODS
  Consecutive patients presenting for screening colonoscopy were included into this study and were randomly assigned to the narrow band imaging group (Group 1) or standard colonoscopy group (Group 2). Primary end point was the adenoma detection rate and secondary aim was the detection rate of advanced adenomas.
  
  
  RESULTS
  Overall, 117 patients were allocated to Group 1 and 120 to Group 2. Both the adenoma detection rate and the detection rate of advanced adenomas were not significantly different between the two groups (respectively, 52.1% vs. 55%, RR=0.95, 95% CI 0.75-1.20; 32.5% vs. 44.2%, RR=0.74, 95% CI 0.53-1.02). No significant difference between the proportions of polypoid and flat adenomas was found. Male gender, no prior history of screening, and endoscopist's adenoma detection rate were independent predictive factors of higher advanced adenoma detection rate.
  
  
  CONCLUSIONS
  In a screening scenario, narrow band imaging did not improve the adenoma nor advanced adenoma detection rates compared to high definition white light colonoscopy.
authors.affiliation: Cancer Epidemiology Unit, CPO Piemonte, AOU Città della Salute e della Scienza, Turin, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Senore
authors.affiliation: Liver Transplant Unit, Molinette Hospital, University of Turin, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Reggio
authors.affiliation: Division of Gastrohepatology, Molinette Hospital, University of Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Musso
authors.affiliation: Division of Gastrohepatology, Molinette Hospital, University of Turin, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Bruno
authors.affiliation: Division of Gastrohepatology, Molinette Hospital, University of Turin, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: De Angelis
authors.affiliation: Department of Oncology, A.O.U. S. Luigi Gonzaga, University of Turin, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Giordanino
authors.affiliation: Department of Oncology, A.O.U. S. Luigi Gonzaga, University of Turin, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Coppo
authors.affiliation: Division of Gastroenterology, A.O.U. Maggiore della Carità, Novara, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Tari
authors.affiliation: Division of Gastroenterology, A.O.U. Maggiore della Carità, Novara, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Pagliarulo
authors.affiliation: Division of Gastroenterology, A.O.U. Maggiore della Carità, Novara, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Carmagnola
authors.affiliation: Division of Gastroenterology, A.O.U. Maggiore della Carità, Novara, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Montino
authors.affiliation: Cancer Epidemiology Unit, CPO Piemonte, AOU Città della Salute e della Scienza, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Silvani
authors.affiliation: Cancer Epidemiology Unit, CPO Piemonte, AOU Città della Salute e della Scienza, Turin, Italy.
authors.forename: Nereo
authors.initials: N
authors.lastname: Segnan
authors.affiliation: Division of Gastrohepatology, Molinette Hospital, University of Turin, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Rizzetto
authors.affiliation: Department of Oncology, A.O.U. S. Luigi Gonzaga, University of Turin, Italy. Electronic address: g.saracco@tin.it.
authors.forename: Giorgio Maria
authors.initials: GM
authors.lastname: Saracco
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000453:epidemiology; D000368:Aged; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods*; D062048:Narrow Band Imaging / Q000379:methods*; D009780:Occult Blood; D011446:Prospective Studies
keywords: Adenoma detection rate; Colonoscopy; Colorectal cancer; Narrow-band imaging; Screening