title: Smart microneedle coatings for controlled delivery and biomedical analysis.
abstract: The work presented demonstrates an unconventional approach in the preparation of smart microneedle (MN) coatings utilising electrohydrodynamic atomisation (EHDA) principles. Stainless steel (600-900 µm in height) MNs were coupled to a ground electrode (in the EHDA coating set-up) with the deposition distance and collecting methodology varied for an ethanol:methanol (50:50) vehicle system. The preparation of nano- and micrometre-scaled pharmaceutical coatings was achieved. Fluorescein dye (serving as potential drug, sensory materials or disease state markers) and polyvinylpyrrolidone (PVP, polymer matrix system) formed the remaining components of the coating formulation. Based on these excipients and by varying the coating process, particles (100 nm to 3 µm) and fibres (400 nm to 1 µm) were deposited directly on MNs in controlled and selectable fashion (flow rates variable ∼ 5-50 µL/min, applied voltage variable 6-19 kV). These demonstrated options for multiple targeting and analysis applications. The underlying EHDA process permits room temperature fabrication, controlled output and scale-up potential for emerging MN devices as drug systems or lab-chip testing devices.
authors.affiliation: Leicester School of Pharmacy, De Montfort University , Leicester , UK.
authors.forename: H
authors.initials: H
authors.lastname: Khan
authors.forename: P
authors.initials: P
authors.lastname: Mehta
authors.forename: H
authors.initials: H
authors.lastname: Msallam
authors.forename: D
authors.initials: D
authors.lastname: Armitage
authors.forename: Z
authors.initials: Z
authors.lastname: Ahmad
mesh_terms: D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000295:instrumentation*; D000431:Ethanol / Q000737:chemistry; D019793:Fluorescein / Q000008:administration & dosage; D000432:Methanol / Q000737:chemistry; D009339:Needles; D011205:Povidone / Q000737:chemistry*; D012869:Skin Absorption
chemical_list: D003287:Contrast Media; D000431:Ethanol; D011205:Povidone; D019793:Fluorescein; D000432:Methanol
keywords: Controlled release; drug delivery; electric-jet; electrohydrodynamic; electrospin; electrospray; microneedles; transdermal