title: Prognostic Significance of Metabolic Tumor Volume Measured by (18)F-FDG PET/CT in Operable Primary Breast Cancer.
abstract: OBJECTIVE
  We investigated whether PET indices measured by (18) F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can predict prognosis in patients with operable primary breast cancer.
  
  
  METHODS
  We reviewed 53 patients with operable primary breast cancer who underwent pretreatment FDG PET/CT. PET indices, maximum standardized uptake value (SUV) and metabolic tumor volume (MTV), were measured in the primary breast tumor (P), metastatic lymph nodes (N) and total tumor (T). The Cox proportional hazards model was used with age, tumor size, clinical lymph node status, method of surgery, presence or absence of neoadjuvant chemotherapy, histological type, histological grade, hormone receptors and HER2 status to predict disease-free survival (DFS) and overall survival (OS).
  
  
  RESULTS
  Median follow-up period was 50 months (range, 17-73 months), during which 17 patients had recurrent disease and nine of whom died. The univariate analysis showed that high SUV of N (NSUV, P = 0.011), MTV of N (NMTV, P = 0.011) and MTV of T (TMTV, P = 0.045) as well as high histological grade (P = 0.008), negative estrogen (P = 0.045) and negative progesterone (P = 0.029) receptor status were associated with shorter DFS. High NSUV (P = 0.035), NMTV (P = 0.035) and TMTV (P = 0.035) as well as high histological grade (P = 0.012) and negative estrogen receptor status (P = 0.009) were associated with shorter OS. NSUV, NMTV and TMTV were found to be significantly associated with high histological grade (P = 0.005). However, those failed to be statistically significant prognostic factors on multivariate analysis.
  
  
  CONCLUSIONS
  PET indices seem to be useful in the preoperative evaluation of prognosis in patients with operable primary breast cancer. NSUV, NMTV and TMTV might be considerable factors associated with patient outcome in operable breast cancer.
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Jahae
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Su Woong
authors.initials: SW
authors.lastname: Yoo
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Sae-Ryung
authors.initials: SR
authors.lastname: Kang
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Sang-Geon
authors.initials: SG
authors.lastname: Cho
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Jong-Ryool
authors.initials: JR
authors.lastname: Oh
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Ari
authors.initials: A
authors.lastname: Chong
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Jung-Joon
authors.initials: JJ
authors.lastname: Min
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Hee-Seung
authors.initials: HS
authors.lastname: Bom
authors.affiliation: Department of Surgery, Chonnam National University Medical School, 42 Jebong-no, Donggu, Gwangju Republic of Korea.
authors.forename: Jung-Han
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School and Hospital, 42 Jebong-no, Donggu, Gwangju 501-757 Republic of Korea.
authors.forename: Ho-Chun
authors.initials: HC
authors.lastname: Song
keywords: Breast cancer; FDG PET/CT; Maximum standardized uptake value; Metabolic tumor volume; Prognosis