title: Aldosterone signaling and soluble adenylyl cyclase-a nexus for the kidney and vascular endothelium.
abstract: The steroid hormone aldosterone regulates the reabsorption of water and ions in the kidney and plays a central role in blood pressure regulation and homeostasis. In recent years, the vascular endothelium has been established as an important aldosterone target organ with major implications in renal and cardiovascular health and disease. Different lines of evidence suggest that the calcium- and bicarbonate-activated soluble adenylyl cyclase (sAC) is a novel mediator of aldosterone signaling in both the kidney and vascular endothelium. This review summarizes our current understanding of the molecular mechanisms of sAC gene expression regulation in the kidney and vascular endothelium and outlines the potential clinical implications of sAC in chronic kidney disease and cardiovascular disease. This review is part of a special issue entitled: The role of soluble adenylyl cyclase in health and disease. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.
authors.affiliation: Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Horstmarer Landweg 39, 48149 Muenster, Germany; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Schmitz
authors.affiliation: Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Horstmarer Landweg 39, 48149 Muenster, Germany.
authors.forename: Stefan-Martin
authors.initials: SM
authors.lastname: Brand
authors.affiliation: Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany. Electronic address: Eva.Brand@ukmuenster.de.
authors.forename: Eva
authors.initials: E
authors.lastname: Brand
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000450:Aldosterone / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D015398:Signal Transduction; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; C579271:ADCY10 protein, human; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Bicarbonate; Endothelial stiffness; Gene expression; Spironolactone; cAMP