title: Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging.
abstract: Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.
authors.affiliation: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hine
authors.affiliation: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: jmitchel@hsph.harvard.edu.
authors.forename: James R
authors.initials: JR
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D005215:Fasting / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D007165:Immunosuppression Therapy; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D012038:Regeneration
chemical_list: C519530:insulin-like growth factor-1, mouse; D007334:Insulin-Like Growth Factor I; D017868:Cyclic AMP-Dependent Protein Kinases