title: [The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation: relationship between infused donor CD4+/CCR7+ T cell subsets and acute graft-versus-host disease].
abstract: In a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7(+)/CD4(+) T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate. Here we present our results on a confirmatory cohort of 137 consecutive patients. Indeed patients who received more than 76% of CCR7(+)/CD4(+) T cells in the graft developed more often acute GVHD be it of low or high grade than those who did not. Determination of the CCR7(+)/CCR7(neg) ratio of CD4(+) T cells in the graft provides a predictive indicator of acute GVHD and could help to define strategies of partial selective T cell depleted transplantation.
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France; Service d'hématologie, center hospitalier de Boulogne-sur-mer, BP 609, 62321 Boulogne-sur-mer cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Choufi
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Thiant
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Trauet
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France; Service d'hématologie, center hospitalier de Boulogne-sur-mer, BP 609, 62321 Boulogne-sur-mer cedex, France; Établissement français du sang (EFS) Nord de France, 95, rue Jemmapes, 59800 Lille, France; Maladies du sang, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Cliquennois
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Cherrel
authors.affiliation: Établissement français du sang (EFS) Nord de France, 95, rue Jemmapes, 59800 Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Boulanger
authors.affiliation: Maladies du sang, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Coiteux
authors.affiliation: Maladies du sang, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Magro
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Labalette
authors.affiliation: EA2686, laboratoire d'immunologie, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France; Service d'hématologie, center hospitalier de Boulogne-sur-mer, BP 609, 62321 Boulogne-sur-mer cedex, France; Établissement français du sang (EFS) Nord de France, 95, rue Jemmapes, 59800 Lille, France; Maladies du sang, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. Electronic address: sfgm-tc-iya@live.fr.
authors.forename: I
authors.initials: I
authors.lastname: Yakoub-Agha
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts / Q000276:immunology; D016026:Bone Marrow Transplantation; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D002648:Child; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology*; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D019520:Living Donors; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D011446:Prospective Studies; D054400:Receptors, CCR7 / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000637:transplantation*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C515370:CCR7 protein, human; D054400:Receptors, CCR7
keywords: Acute GVHD; Allogeneic stem cell transplantation; Allogreffe de cellules souches hématopoïétiques; GVH aiguë; Lymphocytes T CCR7; T cells CCR7