title: Complications of allogeneic hematopoietic stem cell transplantation.
abstract: Infection, graft-versus-host disease (GVHD), and to a lesser extent sinusoidal obstructive syndrome (SOS) represent the major causes of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT). During the last decade, progress in prevention and treatment of these complications led to improvement in the outcome of these patients. Despite the fact that nonmyeloablative regimens have been increasingly used in elderly patients and in patients with co-morbidities, the nonrelapse related mortality remains a challenge and long-term follow-up is required. The objective of this manuscript is to provide an updated concise review of the complications of AHSCT and of the available treatment interventions.
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, George Washington University Medical Center, Washington, USA.
authors.forename: Karim
authors.initials: K
authors.lastname: Arnaout
authors.forename: Nihar
authors.initials: N
authors.lastname: Patel
authors.forename: Maneesh
authors.initials: M
authors.lastname: Jain
authors.forename: Joelle
authors.initials: J
authors.lastname: El-Amm
authors.forename: Farah
authors.initials: F
authors.lastname: Amro
authors.forename: Imad A
authors.initials: IA
authors.lastname: Tabbara
mesh_terms: D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D006084:Graft Rejection / Q000188:drug therapy / Q000517:prevention & control / Q000532:radiotherapy; D006086:Graft vs Host Disease / Q000517:prevention & control; D006402:Hematologic Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D009181:Mycoses / Q000209:etiology / Q000517:prevention & control; D019172:Transplantation Conditioning / Q000009:adverse effects; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome; D014777:Virus Diseases / Q000209:etiology / Q000517:prevention & control; D014916:Whole-Body Irradiation
keywords: Bone marrow transplant; Leukemias; Long-term survival and late effects