title: The impact of receptor-receptor interactions in heteroreceptor complexes on brain plasticity.
abstract: Allosteric mechanisms in receptor heteromers markedly increase the repertoire of receptor recognition and signaling. Of high importance is the altered function in the receptor heteromer versus the receptor homomer. Such a change in receptor function is mainly brought about by agonist induced allosteric receptor-receptor interactions and leads to functional and structural plasticity. Receptor-receptor interactions integrating synaptic and volume transmission signals participate in a significant way in modulating bidirectional synaptic plasticity and thus Hebbian plasticity. One molecular mechanism that can contribute to a change of synaptic weight may be represented by multiple interactions between plasma membrane receptors forming higher order heteroreceptor complexes via oligomerization at the pre- and post-junctional level. Such long-lived heteroreceptor complexes may play a significant role in learning and memory.
authors.affiliation: Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
authors.forename: Luigi F
authors.initials: LF
authors.lastname: Agnati
authors.forename: Dasiel O
authors.initials: DO
authors.lastname: Borroto-Escuela
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D011956:Receptors, Cell Surface
keywords: G protein-coupled receptor; allosteric receptor–receptor interaction; learning; long term depression; long term potentiation; memory plasticity; receptor heteromer; receptor tyrosine kinase; striatum