title: Association between some endocrine-disrupting chemicals and childhood obesity in biological samples of young girls: a cross-sectional study.
abstract: Childhood obesity, a major public health concern, has increased worldwide. Endocrine-disrupting chemicals (EDCs) have recently received attention as a cause of obesity. A cross-sectional study using logistic regression was conducted to investigate the association between some endocrine disrupting chemicals and obesity in young girls. Endogenous steroids expected to be associated with EDCs were also investigated. The target compounds included 7 phthalates (MEP, DBP, MBP, DEHP, MEHP, PA and MBzP), 2 alkylphenols (4-NP and t-OP), bisphenol A and 9 endogenous steroids (DHT, epi-T, T, DHEA, A, P, E1, E2 and E3). PA in urine and MEP, DBP and PA in serum showed statistically significant differences between the control and obese groups, those compounds were considered to be associated with obesity. In addition, DHEA in serum showed a statistically significant difference between obese and control groups. We concluded that these substances can affect the development of obesity.
authors.affiliation: Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea; Department of Chemistry, Interdisciplinary Program of Integrated Biotechnology, Sogang University, Shinsoo-dong, Mapo-gu, Seoul 121-742, Republic of Korea.
authors.forename: Jaeyeon
authors.initials: J
authors.lastname: Choi
authors.affiliation: Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Eom
authors.affiliation: Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: Jiye
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Health Environment, Hoseo Graduate School of Venture, Seoul, Republic of Korea.
authors.forename: Sanghouck
authors.initials: S
authors.lastname: Lee
authors.affiliation: Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea. Electronic address: yjkim@kist.re.kr.
authors.forename: Yunje
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D001559:Benzhydryl Compounds / Q000097:blood / Q000652:urine; D002648:Child; D003430:Cross-Sectional Studies; D052244:Endocrine Disruptors / Q000097:blood* / Q000652:urine*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D063766:Pediatric Obesity / Q000097:blood* / Q000453:epidemiology / Q000652:urine*; D010636:Phenols / Q000097:blood / Q000652:urine; D010795:Phthalic Acids / Q000097:blood / Q000652:urine; D056910:Republic of Korea / Q000453:epidemiology; D013256:Steroids / Q000097:blood / Q000652:urine; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; D013256:Steroids; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Alkylphenol; Bisphenol A; Childhood obesity; Endocrine disrupting chemicals; Endogenous steroids; Phthalate