title: Relation between fluorodeoxyglucose uptake and glucose transporter-1 expression in gastric signet ring cell carcinoma.
abstract: OBJECTIVE
  Gastric signet ring cell carcinoma (GSRC) is known to have low fluorodeoxyglucose (FDG) uptake. The aim of the study was to investigate the relation between FDG uptake and glucose transporter (GLUT)-1 expression and clinicopathologic parameters in cases of GSRC.
  
  
  METHODS
  Forty patients (28 men, mean age 54 ± 12 years) with histologically confirmed GSRC who underwent pre-operative [(18)F]FDG PET/CT were enrolled. Maximum standardized uptake values (SUVmax) were compared with clinicopathologic parameters and GLUT-1 expression. Cases were divided based on GLUT-1 expression in tumor tissues into a membranous group (n = 17) and a cytoplasmic group (n = 23).
  
  
  RESULTS
  Mean SUVmax was significantly higher in the membranous group than in the cytoplasmic group (6.06 ± 2.79 vs. 3.67 ± 1.54, P = 0.03). Gastric wall invasion, depth of invasion, extent of LN metastasis, overall stage, and tumor size were found to be related to SUVmax. On the other hand, age, sex, and the presence of distant metastasis were not related to SUVmax. Multivariate analysis revealed that membranous GLUT-1 expression and the extent of LN metastasis independently predicted high FDG uptake.
  
  
  CONCLUSIONS
  This study demonstrates that high FDG uptake is mediated by membranous GLUT-1 expression in GSRC.
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, San 5, Wonchun-dong, Yeongtong-gu, Suwon, 443-721 Kyunggi-do Republic of Korea.
authors.forename: Bong-Hoi
authors.initials: BH
authors.lastname: Choi
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, San 5, Wonchun-dong, Yeongtong-gu, Suwon, 443-721 Kyunggi-do Republic of Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Song
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, San 5, Wonchun-dong, Yeongtong-gu, Suwon, 443-721 Kyunggi-do Republic of Korea.
authors.forename: Young-Sil
authors.initials: YS
authors.lastname: An
authors.affiliation: Department of Surgery, Ajou University School of Medicine, San 5, Wonchun-dong, Yeongtong-gu, Suwon, 443-721 Kyunggi-do Republic of Korea.
authors.forename: Sang-Uk
authors.initials: SU
authors.lastname: Han
authors.affiliation: Department of Pathology, Ajou University School of Medicine, San 5, Wonchun-dong, Yeongtong-gu, Suwon, 443-721 Kyunggi-do Republic of Korea.
authors.forename: Jang-Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, San 5, Wonchun-dong, Yeongtong-gu, Suwon, 443-721 Kyunggi-do Republic of Korea.
authors.forename: Joon-Kee
authors.initials: JK
authors.lastname: Yoon
keywords: FDG; Glucose transporter-1; Signet ring cell; Stomach cancer