title: PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.
abstract: BACKGROUND
  Suspected coronary artery disease (CAD) is one of the most common, potentially life-threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed to guide the selection of diagnostic strategies for these patients.
  
  
  METHODS
  The PROMISE study is a prospective, randomized trial comparing the effectiveness of 2 initial diagnostic strategies in patients with symptoms suspicious for CAD. Patients are randomized to either (1) functional testing (exercise electrocardiogram, stress nuclear imaging, or stress echocardiogram) or (2) anatomical testing with ≥64-slice multidetector coronary computed tomographic angiography. Tests are interpreted locally in real time by subspecialty certified physicians, and all subsequent care decisions are made by the clinical care team. Sites are provided results of central core laboratory quality and completeness assessment. All subjects are followed up for ≥1 year. The primary end point is the time to occurrence of the composite of death, myocardial infarction, major procedural complications (stroke, major bleeding, anaphylaxis, and renal failure), or hospitalization for unstable angina.
  
  
  RESULTS
  More than 10,000 symptomatic subjects were randomized in 3.2 years at 193 US and Canadian cardiology, radiology, primary care, urgent care, and anesthesiology sites.
  
  
  CONCLUSIONS
  Multispecialty community practice enrollment into a large pragmatic trial of diagnostic testing strategies is both feasible and efficient. The PROMISE trial will compare the clinical effectiveness of an initial strategy of functional testing against an initial strategy of anatomical testing in symptomatic patients with suspected CAD. Quality of life, resource use, cost-effectiveness, and radiation exposure will be assessed.
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH. Electronic address: pamela.douglas@duke.edu.
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Douglas
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Columbus, OH.
authors.forename: Udo
authors.initials: U
authors.lastname: Hoffmann
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Kerry L
authors.initials: KL
authors.lastname: Lee
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Mark
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Hussein R
authors.initials: HR
authors.lastname: Al-Khalidi
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Kevin
authors.initials: K
authors.lastname: Anstrom
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Rowena J
authors.initials: RJ
authors.lastname: Dolor
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kosinski
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Mitchell W
authors.initials: MW
authors.lastname: Krucoff
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH; McConnell Heart Health Center, Columbus, OH.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Mudrick
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Manesh R
authors.initials: MR
authors.lastname: Patel
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Columbus, OH.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Picard
authors.affiliation: Tufts Medical Center, Tufts University School of Medicine, Boston, MA.
authors.forename: James E
authors.initials: JE
authors.lastname: Udelson
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Columbus, OH.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Velazquez
authors.affiliation: National Heart, Lung, and Blood Institute, Bethesda, MD.
authors.forename: Lawton
authors.initials: L
authors.lastname: Cooper
mesh_terms: D000368:Aged; D002637:Chest Pain / Q000209:etiology; D017023:Coronary Angiography / Q000191:economics / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D003362:Cost-Benefit Analysis; D025401:Echocardiography, Stress / Q000191:economics / Q000379:methods; D004562:Electrocardiography / Q000191:economics / Q000379:methods; D005080:Exercise Test / Q000191:economics / Q000379:methods; D005260:Female; D017048:Health Care Costs; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000191:economics / Q000379:methods; D055414:Myocardial Perfusion Imaging / Q000191:economics / Q000379:methods; D011788:Quality of Life