title: Acute renal failure and type B lactic acidosis as first manifestation of extranodal T-cell lymphoblastic lymphoma.
abstract: We describe a rare case of a 19-year-old male patient with a history of epilepsy and developmental delay who presented with acute renal failure (ARF) and lactic acidosis (LA) as the first manifestation of T-cell lymphoblastic lymphoma. Renal ultrasound and CT of the abdomen showed renal parenchymal infiltration, and renal biopsy demonstrated T-cell lymphoblastic lymphoma. LA, ARF and electrolyte abnormalities were refractory to the initial treatment of bicarbonate infusion and hydration. However, these abnormalities rapidly normalised after the initiation of chemotherapy, suggesting that the LA and ARF were secondary to lymphomatous renal infiltration.
authors.affiliation: Department of Internal Medicine, University of Arizona Medical Center, Tucson, Arizona, USA.
authors.forename: Seongseok
authors.initials: S
authors.lastname: Yun
authors.affiliation: Department of Internal Medicine, University of Arizona Medical Center, Tucson, Arizona, USA.
authors.forename: Courtney N
authors.initials: CN
authors.lastname: Walker
authors.affiliation: College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Vincelette
authors.affiliation: Department of Internal Medicine, University of Arizona Medical Center, Tucson, Arizona, USA.
authors.forename: Faiz
authors.initials: F
authors.lastname: Anwer
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology*; D058186:Acute Kidney Injury / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis*; D008297:Male; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis*; D011859:Radiography; D014463:Ultrasonography; D055815:Young Adult