title: Polymorphisms in cyclooxygenase-2 gene and risk of developing coal workers' pneumoconiosis: a case-control study.
abstract: BACKGROUND
  Coal workers' pneumoconiosis (CWP) is characterized by progressive pulmonary fibrosis. Inflammation is crucial in the host response to silica and it contributes to pulmonary fibrosis. Cyclooxygenase-2 is involved in this process. The association between single-nucleotide polymorphisms in cyclooxygenase-2 gene with pneumoconiosis risk was investigated.
  
  
  METHODS
  An association study was conducted by analyzing two single-nucleotide polymorphisms of cyclooxygenase-2 (rs689466 and rs20417) in a case-control study involving 90 patients and 90 healthy individuals (controls). Genotyping was performed by the TaqMan method.
  
  
  RESULTS
  The rs689466 AG and GG and rs689466 GC polymorphisms were significantly less frequent in patients than in controls. Cyclooxygenase-2 rs689466 and rs20417 variant genotypes exhibited 21% and 12% decreased CWP risk, respectively.
  
  
  CONCLUSIONS
  Cyclooxygenase-2 rs689466 and rs20417 polymorphisms were associated with CWP risk.
authors.affiliation: Department of Pneumoconiosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
authors.forename: Lu-Qin
authors.initials: LQ
authors.lastname: Bian
authors.forename: Ling
authors.initials: L
authors.lastname: Mao
authors.forename: Jin
authors.initials: J
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Bi
mesh_terms: D000483:Alleles; D055008:Anthracosis / Q000235:genetics*; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2
keywords: cyclooxygenase-2; gene polymorphism; genotype; pneumoconiosis; risk