title: [Therapeutic use of amiodarone against postoperative fibrillation after cardiac surgery].
abstract: We investigated the effect of amiodarone (AMD) administered intravenously for the treatment of post-operative atrial fibrillation( POAF) after cardiac surgery. After rapid administration of 150 mg for 10 minutes, AMD was administered in 1.0 mg per minute for 6 hours followed by 0.5 mg per minute for 18 hours. AMD was then administered orally 200 mg per day for 1 or 2 weeks. Twenty-five cases were enrolled from January 2010 to June 2013. In 18 cases(72%), the patients were successfully defibrillated by this protocol. In the other 7 cases, the patients required electrical defibrillation, but in 1 patient developed chronic atrial fibrillation. It was thought that AMD could be a choice for POAF.
authors.affiliation: Department of Cardiovascular Surgery, Chest Surgery, Sapporo Chuo Hospital, Japan.
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Osawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Muraki
authors.forename: Taku
authors.initials: T
authors.lastname: Sakurada
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kawaharada
authors.forename: Jun
authors.initials: J
authors.lastname: Sasaki
authors.forename: Eiji
authors.initials: E
authors.lastname: Araki
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006331:Heart Diseases / Q000601:surgery*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone