title: Nitrophenyl-based caged neurotransmitters.
abstract: Nitroaromatic photochemical protecting groups were developed for organic synthesis in 1966. Since the early 1990s, this type of chromophore has been used by neuroscientists to liberate a wide variety of amino acid neurotransmitters such as ACh, glutamate, GABA, and glycine, among others. Since 2001, several laboratories have used two-photon excitation of nitroaromatic cages for highly localized uncaging of glutamate in acute brain slices.
authors.forename: Graham C R
authors.initials: GC
authors.lastname: Ellis-Davies
mesh_terms: D016503:Drug Delivery Systems; D008027:Light; D018377:Neurotransmitter Agents / Q000493:pharmacokinetics*; D009596:Nitrophenols / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents; D009596:Nitrophenols