title: One hundred and twenty cases of enduring sexual dysfunction following treatment.
abstract: BACKGROUND
  There have been reports for over a decade linking serotonin reuptake inhibitors, finasteride and isotretinoin with enduring sexual dysfunction after treatment stops.
  
  
  OBJECTIVE
  To explore the clinical pictures linked to all 3 drugs.
  
  
  METHODS
  We have selected 120 reports to RxISK.org reporting the problem and mined these for data on age, gender, drug of use, and impact of the problem.
  
  
  RESULTS
  The data make it clear that the three drugs show extensive overlap in symptom profile, regardless of sex or country of origin.
  
  
  CONCLUSIONS
  The availability of 120 reports from over 20 countries add to the case for the validity of the syndrome. This is severe and enduring condition can result in death. An understanding of its physiology and an approach to treatment are needed.
authors.affiliation: North Wales Department of Psychological Medicine, Bangor, Wales, UK.
authors.forename: Carys
authors.initials: C
authors.lastname: Hogan
authors.affiliation: North Wales Department of Psychological Medicine, Bangor, Wales, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Le Noury
authors.affiliation: North Wales Department of Psychological Medicine, Bangor, Wales, UK.
authors.forename: David
authors.initials: D
authors.lastname: Healy
authors.affiliation: David Braley & Nancy Gordon Chair of Family Medicine, Department of Family Medicine, McMaster University, ON, Canada.
authors.forename: Derelie
authors.initials: D
authors.lastname: Mangin
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018120:Finasteride / Q000009:adverse effects*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D058891:5-alpha Reductase Inhibitors; D018120:Finasteride; D015474:Isotretinoin; D007641:Keratolytic Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: SSRIs; erectile dysfunction; finasteride; genital anesthesia; isotretinoin; loss of libido