title: Mortality after total hip replacement surgery: A systematic review.
abstract: Total hip replacement causes a short-term increase in the risk of mortality. It is important to quantify this and to identify modifiable risk factors so that the risk of post-operative mortality can be minimised. We performed a systematic review and critical evaluation of the current literature on the topic. We identified 32 studies published over the last 10 years which provide either 30-day or 90-day mortality data. We estimate the pooled incidence of mortality during the first 30 and 90 days following hip replacement to be 0.30% (95% CI 0.22 to 0.38) and 0.65% (95% CI 0.50 to 0.81), respectively. We found strong evidence of a temporal trend towards reducing mortality rates despite increasingly co-morbid patients. The risk factors for early mortality most commonly identified are increasing age, male gender and co-morbid conditions, particularly cardiovascular disease. Cardiovascular complications appear to have overtaken fatal pulmonary emboli as the leading cause of death after hip replacement. Cite this article: Bone Joint Res 2014;3:175-82.
authors.affiliation: Southmead Hospital, Musculoskeletal Research Unit, AOC (Lower Level), Westbury-on-Trym, Bristol BS10 5NB, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Berstock
authors.affiliation: Southmead Hospital, Musculoskeletal Research Unit, AOC (Lower Level), Westbury-on-Trym, Bristol BS10 5NB, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Beswick
authors.affiliation: Southmead Hospital, Musculoskeletal Research Unit, AOC (Lower Level), Westbury-on-Trym, Bristol BS10 5NB, UK.
authors.forename: E
authors.initials: E
authors.lastname: Lenguerrand
authors.affiliation: Southmead Hospital, Musculoskeletal Research Unit, AOC (Lower Level), Westbury-on-Trym, Bristol BS10 5NB, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Whitehouse
authors.affiliation: Southmead Hospital, Musculoskeletal Research Unit, AOC (Lower Level), Westbury-on-Trym, Bristol BS10 5NB, UK.
authors.forename: A W
authors.initials: AW
authors.lastname: Blom
keywords: Hip arthroplasty; Meta-analysis; Mortality; Systematic review