title: Transfer of peanut IgE sensitisation after combined pancreas-kidney transplant.
abstract: BACKGROUND
  The transfer of peanut allergy has been reported following solid organ transplantation.
  
  
  OBJECTIVE
  Present a case of peanut sensitization following combined pancreas-and-kidney transplantation.
  
  
  METHODS
  Circulating specific IgE against peanut were measured in serum samples collected from the transplant recipient 1 month before transplantation, and 1, 3 and 6 months after transplantation. Skin tests were performed 1, 3 and 6 months following transplant.
  
  
  RESULTS
  The organ recipient's pre-transplant peanut IgE levels were negative. At 1 month post-transplant, the patient had a 6 mm skin test to peanut and had serum IgE to peanut Arah1 of 0.79 kU/L. At 3 months, skin test size and IgE to peanut Arah1 decreased to 4 mm, and 0.69 kU/L respectively. At 6 months, the patient's skin test and IgE to peanuts were negative. At that time, the patient underwent a peanut food challenge without a clinical reaction to suggest allergy.
  
  
  CONCLUSIONS
  We report the development of IgE peanut sensitization in a recipient of a combined pancreas and kidney transplantation. Increasing awareness of this allergen sensitization following transplantation may help prevent serious allergic reactions in transplant recipients.
authors.affiliation: Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
authors.forename: A
authors.initials: A
authors.lastname: Berry
authors.forename: J
authors.initials: J
authors.lastname: Campsen
authors.forename: F
authors.initials: F
authors.lastname: Shihab
authors.forename: R
authors.initials: R
authors.lastname: Firszt
mesh_terms: D000328:Adult; D000918:Antibody Specificity / Q000276:immunology; D010367:Arachis / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016035:Pancreas Transplantation / Q000009:adverse effects*; D021183:Peanut Hypersensitivity / Q000209:etiology*; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E
keywords: IgE; anaphylaxis; peanut allergy; peanut sensitization; post-transplant associated food allergies (PAFA); skin prick testing; transplant