title: Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach.
abstract: The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis.
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, South Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
authors.forename: Kyu-Sup
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
authors.forename: Jong-Kil
authors.initials: JK
authors.lastname: Joo
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, South Korea.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
authors.forename: Jung-Bin
authors.initials: JB
authors.lastname: Son
authors.affiliation: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
authors.forename: Jong-Ha
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biomaterial Science, College of Natural Resources and Life Science, Pusan National University, Miryang 627-706, South Korea.
authors.forename: Dae-Youn
authors.initials: DY
authors.lastname: Hwang
authors.affiliation: Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, South Korea.
authors.forename: Man-Ho
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, South Korea.
authors.forename: Hong-Gu
authors.initials: HG
authors.lastname: Lee
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D004195:Disease Models, Animal; D015536:Down-Regulation; D015180:Electrophoresis, Gel, Two-Dimensional; D004715:Endometriosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014599:Uterus / Q000473:pathology
chemical_list: D015415:Biomarkers; D006242:Haptoglobins