title: Automation of a portable extracorporeal circulatory support system with adaptive fuzzy controllers.
abstract: The presented work relates to the procedure followed for the automation of a portable extracorporeal circulatory support system. Such a device may help increase the chances of survival after suffering from cardiogenic shock outside the hospital, additionally a controller can provide of optimal organ perfusion, while reducing the workload of the operator. Animal experiments were carried out for the acquisition of haemodynamic behaviour of the body under extracorporeal circulation. A mathematical model was constructed based on the experimental data, including a cardiovascular model, gas exchange and the administration of medication. As the base of the controller fuzzy logic was used allowing the easy integration of knowledge from trained perfusionists, an adaptive mechanism was included to adapt to the patient's individual response. Initial simulations show the effectiveness of the controller and the improvements of perfusion after adaptation.
authors.affiliation: Faculty of Informatics, Department of Robotics and Embedded Systems, Technische Universität München, Munich, Germany; German Heart Center Munich, Department of Cardiovascular Surgery, Department of Experimental Surgery, Technische Universität München, Munich, Germany. Electronic address: mendozag@in.tum.de.
authors.forename: A
authors.initials: A
authors.lastname: Mendoza García
authors.affiliation: German Heart Center Munich, Department of Cardiovascular Surgery, Department of Experimental Surgery, Technische Universität München, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Krane
authors.affiliation: Faculty of Informatics, Department of Robotics and Embedded Systems, Technische Universität München, Munich, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Baumgartner
authors.affiliation: Faculty of Informatics, Department of Robotics and Embedded Systems, Technische Universität München, Munich, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Sprunk
authors.affiliation: German Heart Center Munich, Department of Cardiovascular Surgery, Department of Experimental Surgery, Technische Universität München, Munich, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Schreiber
authors.affiliation: German Heart Center Munich, Department of Cardiovascular Surgery, Department of Experimental Surgery, Technische Universität München, Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Eichhorn
authors.affiliation: German Heart Center Munich, Department of Cardiovascular Surgery, Department of Experimental Surgery, Technische Universität München, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Lange
authors.affiliation: Faculty of Informatics, Department of Robotics and Embedded Systems, Technische Universität München, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Knoll
mesh_terms: D000465:Algorithms; D000553:Ambulatory Care; D000818:Animals; D001331:Automation; D002317:Cardiovascular Agents / Q000008:administration & dosage; D003198:Computer Simulation; D004562:Electrocardiography; D005112:Extracorporeal Circulation / Q000295:instrumentation / Q000379:methods*; D017143:Fuzzy Logic; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012770:Shock, Cardiogenic / Q000503:physiopathology / Q000628:therapy; D034421:Sus scrofa
chemical_list: D002317:Cardiovascular Agents
keywords: Adaptive control; Cardiovascular modelling; Control; Extracorporeal circulation; Extracorporeal support system; Fuzzy control; Gas exchange modelling; Haemodynamic simulation