title: Correlation study of chronic nonbacterial prostatitis with the levels of COX-2 and PGE2 in prostatic secretion.
abstract: OBJECTIVE
  The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP).
  
  
  METHODS
  A total of 172 CNBP patients and 151 healthy males were recruited as CNBP and control group, respectively. The prostatic fluid was collected and tested by pre- and post-massage test. White blood cell (WBC) number was counted, and the contents of COX-2 and PGE2 were determined by double antibody-based sandwich enzyme-linked immuno-sorbent assay. The pain and discomfort of each patient were scored according to the National Institutes of Health chronic prostatitis symptom index.
  
  
  RESULTS
  Compared with the control group, CNBP group displayed significantly higher WBC count, COX-2 level, and PGE2 level. Contents of COX-2 and PGE2 in prostatic secretion of CNBP group were positively correlated with pain scores (r = 0.855 and 0.675, respectively, P < 0.01) and total symptom scores (r = 0.674 and 0.566, respectively, P < 0.01). A significantly positive correlation between COX-2 and PGE2 levels was also discovered (r = 0.493, P < 0.05). The WBC number was not obviously correlated with the accumulations of COX-2 and PGE2 or the clinic symptoms of CNBP.
  
  
  CONCLUSIONS
  Increase in PGE2 concentration caused by activated COX-2 pathway may contribute to the pain or discomfort symptom of the CNBP patients. Our results indicate that selective COX-2 inhibitors have application prospect in CNBP treatment.
authors.affiliation: Department of Urology, Dongying People's Hospital, No. 317, South First Road, Dongying District, Dongying, 257091, Shandong, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yuan
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Wentao
authors.initials: W
authors.lastname: Deng
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Lai
authors.forename: Zaichun
authors.initials: Z
authors.lastname: Yan
authors.forename: Ruqiang
authors.initials: R
authors.lastname: Zheng
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D010147:Pain Measurement; D011472:Prostatitis / Q000378:metabolism*; D016482:Urinalysis
chemical_list: D051546:Cyclooxygenase 2; D015232:Dinoprostone