title: Single-trial EEG-informed fMRI reveals spatial dependency of BOLD signal on early and late IC-ERP amplitudes during face recognition.
abstract: Simultaneous EEG-fMRI has opened up new avenues for improving the spatio-temporal resolution of functional brain studies. However, this method usually suffers from poor EEG quality, especially for evoked potentials (ERPs), due to specific artifacts. As such, the use of EEG-informed fMRI analysis in the context of cognitive studies has particularly focused on optimizing narrow ERP time windows of interest, which ignores the rich diverse temporal information of the EEG signal. Here, we propose to use simultaneous EEG-fMRI to investigate the neural cascade occurring during face recognition in 14 healthy volunteers by using the successive ERP peaks recorded during the cognitive part of this process. N170, N400 and P600 peaks, commonly associated with face recognition, were successfully and reproducibly identified for each trial and each subject by using a group independent component analysis (ICA). For the first time we use this group ICA to extract several independent components (IC) corresponding to the sequence of activation and used single-trial peaks as modulation parameters in a general linear model (GLM) of fMRI data. We obtained an occipital-temporal-frontal stream of BOLD signal modulation, in accordance with the three successive IC-ERPs providing an unprecedented spatio-temporal characterization of the whole cognitive process as defined by BOLD signal modulation. By using this approach, the pattern of EEG-informed BOLD modulation provided improved characterization of the network involved than the fMRI-only analysis or the source reconstruction of the three ERPs; the latter techniques showing only two regions in common localized in the occipital lobe.
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France; Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106 , 13385 Marseille, France. Electronic address: jonathan.wirsich@univ-amu.fr.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wirsich
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106 , 13385 Marseille, France. Electronic address: christian.benar@univ-amu.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Bénar
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France. Electronic address: jean-philippe.ranjeva@univ-amu.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ranjeva
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France; Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106 , 13385 Marseille, France. Electronic address: mederic.descoins@gmail.com.
authors.forename: Médéric
authors.initials: M
authors.lastname: Descoins
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France. Electronic address: elisabeth.soulier@univ-amu.fr.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Soulier
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France. Electronic address: arnaud.le-troter@univ-amu.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Le Troter
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France. Electronic address: sylviane.gouny@univ-amu.fr.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Confort-Gouny
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106 , 13385 Marseille, France. Electronic address: catherine.liegeois-chauvel@univ-amu.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Liégeois-Chauvel
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie médicale, CEMEREM, 13385 Marseille, France. Electronic address: maxime.guye@univ-amu.fr.
authors.forename: Maxime
authors.initials: M
authors.lastname: Guye
mesh_terms: D000328:Adult; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005145:Face; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*; D055815:Young Adult
keywords: Evoked potentials; Face recognition; ICA; Simultaneous EEG-fMRI; Ventral visual pathway