title: Physicochemical properties, antioxidant activities and protective effect against acute ethanol-induced hepatic injury in mice of foxtail millet (Setaria italica) bran oil.
abstract: This study was designed to investigate physicochemical characterization of the oil extracted from foxtail millet bran (FMBO), and the antioxidant and hepatoprotective effects against acute ethanol-induced hepatic injury in mice. GC-MS analysis revealed that unsaturated fatty acids (UFAs) account for 83.76% of the total fatty acids; in particular, the linoleic acid (C18:2) is the predominant polyunsaturated fatty acid (PUFA), and the compounds of squalene and six phytosterols (or phytostanols) were identified in unsaponifiable matter of FMBO. The antioxidant activity examination of FMBO in vitro showed highly ferric-reducing antioxidant power and scavenging effects against DPPH· and HO· radicals. Furthermore, the protective effect of FMBO against acute hepatic injuries induced by ethanol was verified in mice. In this, intragastric administration with different dosages of FMBO in mice ahead of acute ethanol administration could observably antagonize the ethanol-induced increases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), and the hepatic malondialdehyde (MDA) levels, respectively, along with enhanced hepatic superoxide dismutase (SOD) levels relative to the control. Hepatic histological changes were also observed and confirmed that FMBO is capable of attenuating ethanol-induced hepatic injury.
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, No. 193 Tunxi Road, Hefei, 230009, P. R. China. pangmin@hfut.edu.cn jiangshaotong@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Pang
authors.forename: Shujian
authors.initials: S
authors.lastname: He
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Xinmin
authors.initials: X
authors.lastname: Cao
authors.forename: Lili
authors.initials: L
authors.lastname: Cao
authors.forename: Shaotong
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004043:Dietary Fiber / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D032983:Setaria Plant / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D004043:Dietary Fiber; D010936:Plant Extracts; D010938:Plant Oils; D020011:Protective Agents; D014280:Triglycerides; D000431:Ethanol; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase