title: Lipid landscapes and pipelines in membrane homeostasis.
abstract: The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.
authors.affiliation: 1] Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany. [2] Membrane Biochemistry & Biophysics, Bijvoet Center for Biomolecular Research and Institute of Biomembranes, Utrecht University, the Netherlands.
authors.forename: Joost C M
authors.initials: JC
authors.lastname: Holthuis
authors.affiliation: Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
authors.forename: Anant K
authors.initials: AK
authors.lastname: Menon
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry* / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008563:Membrane Lipids / Q000032:analysis / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D015388:Organelles / Q000737:chemistry / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D008051:Lipid Bilayers; D008563:Membrane Lipids; D013107:Sphingolipids; C030363:lipid transfer protein