title: HLA-DRB1*08:02 Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients.
abstract: BACKGROUND
  Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated with d-penicillamine, gold salts, or bucillamine (Buc), and represents a drug hypersensitivity reaction. Striking associations of human leukocyte antigen (HLA) alleles with adverse reactions have recently been reported for many drugs.
  
  
  METHODS
  We investigated the association of HLA class II with Buc-induced proteinuria (BI-Pro) in 485 Japanese RA patients treated with Buc, of whom 25 had developed BI-Pro.
  
  
  CONCLUSIONS
  This preliminary study showed a highly significant association of DRB1*08:02 with BI-Pro (P = 1.09 × 10(-6), corrected P [Pc] = 1.96 × 10(-5), odds ratio [OR] 25.17, 95% confidence interval [CI] 7.98-79.38). DQB1*04:02 was also significantly associated with increased risk of BI-Pro (P = 2.44 × 10(-5), Pc = 2.69 × 10(-4), OR 10.35, 95%CI 3.99-26.83). These findings provide useful information for promoting personalized medicine for RA.
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Shomi
authors.initials: S
authors.lastname: Oka
authors.affiliation: Department of Rheumatology, Tokyo Metropolitan Tama Medical Center, Musashidai, Fuchu, Japan. ; Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Department of Rheumatology, Tokyo Metropolitan Tama Medical Center, Musashidai, Fuchu, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Sugii
authors.affiliation: Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hashimoto
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Komiya
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Naoshi
authors.initials: N
authors.lastname: Fukui
authors.affiliation: Nagasaki Medical Center, National Hospital Organization, Kubara, Omura, Japan.
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Miyashita
authors.affiliation: Nagasaki Medical Center, National Hospital Organization, Kubara, Omura, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.affiliation: Department of Rheumatology, Yokohama Minami Kyosai Hospital, Rokuura Higashi, Kanazawa-ku, Yokohama, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Suda
authors.affiliation: Department of Rheumatology, Yokohama Minami Kyosai Hospital, Rokuura Higashi, Kanazawa-ku, Yokohama, Japan.
authors.forename: Shouhei
authors.initials: S
authors.lastname: Nagaoka
authors.affiliation: Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tennodai, Tsukuba, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Tsuchiya
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
keywords: HLA-DRB1*08:02; bucillamine; disease-modifying anti-rheumatic drugs; drug-induced proteinuria; rheumatoid arthritis