title: Primary gallbladder small lymphocytic lymphoma as a rare postcholecystectomy finding.
abstract: Introduction. Primary lymphoma of the gallbladder is an extremely rare entity with approximately 50 cases reported so far. In many of these cases the presenting symptoms were mimicking symptomatic gallstone disease and the diagnosis was made postoperatively, especially when the preoperative imaging results were far from suspicious for malignant disease. Patients and Methods. We report a case of primary lymphoma of the gallbladder in an 85-year-old man with gallstone disease, who was admitted for elective cholecystectomy 2 months after an episode of acute cholecystitis and pancreatitis. Histological evaluation of the specimen revealed a small lymphocytic lymphoma of the gallbladder. This type of primary gallbladder lymphoma has not been previously reported. Discussion. The most common primary lymphomas of the gallbladder are MALT lymphomas and diffuse large B-cell lymphomas, although a variety of other histological types have been reported. The association of these lesions with chronic inflammation is the most convincing theory for their pathogenesis. For lesions confined to the gallbladder, cholecystectomy is considered to be sufficient, while supplementary chemotherapy significantly improves prognosis in more advanced disease.
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Psarras
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Nikolaos
authors.identifier: 0000-0001-7703-7854
authors.initials: N
authors.lastname: Symeonidis
authors.affiliation: 2nd Department of Internal Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Euthymia
authors.initials: E
authors.lastname: Vlachaki
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Minas
authors.identifier: 0000-0001-6476-5537
authors.initials: M
authors.lastname: Baltatzis
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Papatolios
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Efstathios
authors.initials: E
authors.lastname: Pavlidis
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Mouratidou
authors.affiliation: Department of Pathology, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Venizelos
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Pavlidis
authors.affiliation: 2nd Department of Propedeutical Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Sakantamis
authors.affiliation: Department of Pathology, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Nikolaidou