title: Clinical value of visually identifiable 18F-fluorodeoxyglucose uptake in primary papillary thyroid microcarcinoma.
abstract: OBJECTIVE
  This study evaluates the relationship between visually identifiable (18)F-fluorodeoxyglucose (FDG) uptake in primary papillary thyroid microcarcinoma (PTMC) and tumor aggressiveness.
  
  
  METHODS
  Historical cohort study.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Clinicopathological factors and PET/CT findings of 219 PTMC surgical patients who underwent preoperative (18)F-FDG positron emission tomography/computed tomography (PET/CT) were retrospectively reviewed.
  
  
  RESULTS
  (18)F-FDG uptake was observed in the tumors of 124 (56.6%) patients. Tumor size (odds ratio [OR] = 1.774; 95% confidence interval [CI], 1.416-2.223; P < .0001) and Hashimoto thyroiditis (OR = 2.815; CI, 1.237-6.404; P = .014) independently predicted (18)F-FDG uptake. Tumor size (OR = 1.495; CI, 1.217-1.835; P < .0001) and BRAF(V600E) mutation (OR = 3.320; CI, 1.056-10.432; P = .040) independently predicted extrathyroidal invasion. Multiplicity (OR = 2.375; CI, 1.278-4.415; P = .006) independently predicted central lymph node metastasis.
  
  
  CONCLUSIONS
  (18)F-FDG uptake in PTMC depends on tumor size and Hashimoto thyroiditis. Therefore, preoperative PET/CT for PTMC may not help in evaluating tumor aggressiveness.
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Seung Ook
authors.initials: SO
authors.lastname: Hwang
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Jin Koo
authors.initials: JK
authors.lastname: Kang
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Hyang Hee
authors.initials: HH
authors.lastname: Choi
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Wan Wook
authors.initials: WW
authors.lastname: Kim
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Ho Yong
authors.initials: HY
authors.lastname: Park
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea jjh01@knu.ac.kr.
authors.forename: Jin Hyang
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose uptake; extrathyroidal invasion; lymph node metastasis; papillary thyroid microcarcinoma; positron emission tomography/computed tomography