title: Directing traffic and autophagy in axonal transport.
abstract: In this issue of Developmental Cell, Fu et al. (2014) address what determines persistent directional movement along microtubules of organelles capable of bidirectional transit. They show that retrograde axonal autophagosome transport is mediated by the scaffolding protein JIP1, which not only inhibits anterograde movement but may also promote autophagosome maturation.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address: phollenb@purdue.edu.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hollenbeck
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001370:Axonal Transport / Q000502:physiology*; D004398:Dyneins / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D010588:Phagosomes
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C480860:Map1lc3b protein, mouse; C490665:Mapk8ip protein, mouse; D008869:Microtubule-Associated Proteins; D004398:Dyneins; D016547:Kinesins