title: Layer-by-layer films as biomaterials: bioactivity and mechanics.
abstract: Layer-by-layer (LbL) assembly offers a facile approach toward biomaterials of nanoscale thickness. Bioactivity may be realized through incorporation of biomolecular species within the film architecture, and film mechanics may be controlled through post-formation chemical cross-linking steps. This short review focuses on recent efforts toward the simultaneous control of LbL film bioactive and mechanical properties, with a particular focus on approaches yielding cellular outcomes dependent on both of these properties. Challenges and opportunities toward the independent control of film rigidity and bioactivity are highlighted.
authors.affiliation: a Département de Biologie, ERRMECe , I-Mat, Université de Cergy-Pontoise , Cergy-Pontoise Cedex 95302 , France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Pauthe
authors.forename: Paul R
authors.initials: PR
authors.lastname: Van Tassel
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials
keywords: biomaterial; chemical cross-linking; layer-by-layer; nanofilm; polyelectrolyte