title: Competitive endogenous RNAs cannot alter microRNA function in vivo.
abstract: In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
authors.affiliation: RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, ASC4-2053, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: jennifer.broderick@umassmed.edu.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Broderick
authors.affiliation: RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, ASC4-2053, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: phillip.zamore@umassmed.edu.
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Zamore
mesh_terms: D000818:Animals; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D034622:RNA Interference
chemical_list: D035683:MicroRNAs; C544354:Mirn122 microRNA, mouse