title: IGH amplification in patients with B cell lymphoma unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt's lymphoma.
abstract: B cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt's lymphoma (BL) (B-UNC/BL/DLBCL) is a new category of tumors that have features resembling both DLBCL and BL. These tumors have large and medium sized cells with greater irregularity of nuclei and more prominent nucleoli than BL. Approximately 35% to 50% have C-MYC rearrangements, although half are non-immunoglobulin variants. We identified six cases of B-UNC/BL/DLBCL with low-level IGH amplification. Four patients died with a median survival of 7 months (range, 6-20). In conclusion, to our knowledge low-level IGH amplification has not been previously described and should be evaluated for in this patient population.
authors.affiliation: Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Bellone
authors.affiliation: Cytogenetics, Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Ann-Leslie
authors.initials: AL
authors.lastname: Zaslav
authors.affiliation: Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Tahmeena
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: Cytogenetics, Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Htien L
authors.initials: HL
authors.lastname: Lee
authors.affiliation: Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Yupo
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Youjun
authors.initials: Y
authors.lastname: Hu
keywords: B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt’s lymphoma; BCL2; C-MYC; IGH