title: In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction.
abstract: Polysaccharide-based hydrogels are remarkable materials for the biomedical fields because of its excellent biodegradation and biocompatibility. In this work, a novel polysaccharide-based hydrogel was fabricated by in situ crosslinking of starch-based nanoparticles and polyvinylamine. Starch was decorated with cholesterol group and aldehyde groups. TEM and DLS showed that the cholesterol modified oxidation starch (OCS) exhibited a core-shell nanoparticles with mean size of ∼143 nm in aqueous. The hydrogel was then synthesized via Schiff base reaction. Rheological measurements demonstrated the incorporation of cholesterol groups not only reduced the gel time but also improved the storage modulus of the hydrogel compared with the oxide starch crosslinked hydrogel. SEM showed the OCS based hydrogels possess a well-defined porous structure. Furthermore, doxorubicin (DOX) was used as model drug to investigate the control and release properties of OCS hydrogels. This OCS hydrogel would be a promising drug carrier for biomedical applications.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 130022, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Yangling
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 130022, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 130022, PR China. Electronic address: tanying@ciac.ac.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 130022, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Xu
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 130022, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Cuige
authors.initials: C
authors.lastname: Lu
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 130022, PR China. Electronic address: pxwang@ciac.ac.cn.
authors.forename: Pixin
authors.initials: P
authors.lastname: Wang
mesh_terms: D020100:Hydrogels / Q000138:chemical synthesis* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D012545:Schiff Bases / Q000138:chemical synthesis / Q000378:metabolism; D013213:Starch / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D020100:Hydrogels; D012545:Schiff Bases; D013213:Starch
keywords: Hydrogel; In situ; Nanoparticles; Schiff base; Starch