title: In vitro study of nanostructured diopside coating on Mg alloy orthopedic implants.
abstract: The high corrosion rate of Mg alloys has hindered their application in various areas, particularly for orthopedic applications. In order to decrease the corrosion rate and to improve the bioactivity, mechanical stability and cytocompatibility of the Mg alloy, nanostructured diopside (CaMgSi2O6) has been coated on AZ91 Mg alloy using a combined micro arc oxidation (MAO) and electrophoretic deposition (EPD) method. The crystalline structure, the morphology and the composition of the samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Electrochemical corrosion test, immersion test, and compression test were used to evaluate the corrosion resistance, the in vitro bioactivity and the mechanical stability of the samples, respectively. The cytocompatibility of the samples was tested by the cell viability and the cell attachment of L-929 cells. The results confirmed that the diopside coating not only slows down the corrosion rate, but also enhances the in vitro bioactivity, mechanical stability and cytocompatibility of AZ91 Mg alloy. Therefore, Mg alloy coated with nanostructured diopside offers a promising approach for biodegradable bone implants.
authors.affiliation: Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran; School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA; School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA. Electronic address: mehdi.razavi@okstate.edu.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Razavi
authors.affiliation: Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammadhossein
authors.initials: M
authors.lastname: Fathi
authors.affiliation: Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Savabi
authors.affiliation: School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA.
authors.forename: Daryoosh
authors.initials: D
authors.lastname: Vashaee
authors.affiliation: School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA; School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA. Electronic address: lobat.tayebi@okstate.edu.
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D019245:Compressive Strength; D003343:Corrosion; D055664:Electrochemical Techniques; D008274:Magnesium / Q000737:chemistry*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D019736:Prostheses and Implants; D012824:Silicic Acid / Q000737:chemistry*
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D012824:Silicic Acid; C074224:diopside; D008274:Magnesium
keywords: Biodegradable Mg alloy; Coating; Diopside; In vitro study; Orthopedic applications