title: Predictivity and fate of metal ion release from metal-on-metal total hip prostheses.
abstract: Blood metal ion levels in 72 patients with large head metal-on-metal hip arthroplasty were studied to determine the correlation between the values measured in whole blood and urine. Urinary cobalt and chromium levels of 30μg and 21μg, respectively, adjusted to creatinine were found to correspond to the 7μg/l cut-off value that has been accepted in whole blood. Cobalt and chromium levels in whole blood and urine both significantly correlated with increased acetabular component inclination angle over 50 degrees and pain scores. There was no correlation with socket anteversion angle or femoral head diameter. The data support the use of urinary measurement of metal ions adjusted to creatinine to monitor patients with large head metal-on-metal total hip arthroplasty.
authors.affiliation: Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Via Giustiniani 2, I-35128 Padova, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Nicolli
authors.affiliation: Division of Orthopaedics and Trauma, Hospital of Este (Padova), Via San Fermo 10, I-35042 Este (Padova), Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Bisinella
authors.affiliation: Division of Orthopaedics and Trauma, Hospital of Este (Padova), Via San Fermo 10, I-35042 Este (Padova), Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Padovani
authors.affiliation: Division of Orthopaedics and Trauma, Hospital of Este (Padova), Via San Fermo 10, I-35042 Este (Padova), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Vitella
authors.affiliation: Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Via Giustiniani 2, I-35128 Padova, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Chiara
authors.affiliation: Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Via Giustiniani 2, I-35128 Padova, Italy. Electronic address: andrea.trevisan@unipd.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Trevisan
mesh_terms: D000077:Acetabulum / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001826:Body Fluids / Q000378:metabolism; D002857:Chromium / Q000097:blood* / Q000652:urine; D003035:Cobalt / Q000097:blood* / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D005270:Femur Head / Q000473:pathology / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007477:Ions / Q000097:blood / Q000652:urine; D008297:Male; D061825:Metal-on-Metal Joint Prostheses / Q000009:adverse effects*; D008875:Middle Aged; D010351:Patient Discharge; D011237:Predictive Value of Tests; D011474:Prosthesis Design
chemical_list: D007477:Ions; D002857:Chromium; D003035:Cobalt; D003404:Creatinine
keywords: chromium; cobalt; total hip prostheses; urine; whole blood