title: (18)F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer.
abstract: BACKGROUND
  (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography ((PET) safely predicts axillary status in patients with breast cancer, but is not sufficiently accurate in early breast cancer patients. This study analyzed the value of (18)F-FDG PET/computed tomography (CT) with contrast enhancement in detecting axillary lymph node involvement in T1 breast cancer patients.
  
  
  METHODS
  Contrast-enhanced (18)F-FDG PET/CT was performed within 20 days of surgery in 143 breast cancer patients with tumors ≤2 cm in size. The patients underwent either axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB), and histopathology reports were used to provide the definitive diagnosis against which the contrast-enhanced (18)F-FDG PET/CT study results were compared.
  
  
  RESULTS
  The sensitivity, specificity, and negative and positive predictive values of contrast-enhanced (18)F-FDG PET/CT in detecting axillary involvement were 70.0%, 92.2%, 88.8%, and 77.8%, respectively, in the entire series of 143 patients, with eight false-positive and 12 false negative results. The false-negative results were associated with the number of metastatic lymph nodes and the rate of FDG uptake.
  
  
  CONCLUSIONS
  Contrast-enhanced (18)F-FDG PET/CT cannot replace histologic staging using SLNB in patients with breast cancer, but (18)F-FDG PET/CT increases the sensitivity for predicting axillary node metastasis, and allows for a selective approach to either ALND or SLNB, even in patients with T1 breast cancer.
authors.affiliation: Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu, Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kong
authors.affiliation: Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu, Korea.
authors.forename: Kyung Ah
authors.initials: KA
authors.lastname: Chun
authors.affiliation: Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu, Korea.
authors.forename: Ihn Ho
authors.initials: IH
authors.lastname: Cho
authors.affiliation: Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu, Korea.
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Lee
keywords: Axillary lymph node; Breast cancer; FDG; PET/CT