title: Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells.
abstract: The upregulation of bone morphogenetic protein and activin membrane‑bound inhibitor (BAMBI) has been observed in several types of malignant cancer, including thyroid, ovarian, liver and colorectal cancer. However, the pathological role and the regulatory mechanism of BAMBI in gastric cancer remain to be elucidated. The present study revealed that the expression of BAMBI was upregulated in gastric cancer tissue, and was correlated with tumor metastasis, disease recurrence and low survival rates in patients. Knockdown of BAMBI in aggressive gastric cancer cell lines significantly inhibited their malignant behavior, including in vitro invasion and cell proliferation. β‑catenin expression was downregulated as a result of knocking down of BAMBI, and TGF-β was downregulated in a similar manner. These results demonstrated the association between BAMBI expression and gastric cancer progression, and indicate a promising direction for developing novel strategies to improve the prognosis and therapy of gastric cancer.
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China.
authors.forename: Xilin
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China.
authors.forename: Heng
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China.
authors.forename: Liqing
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China.
authors.forename: Longgang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Sanyuan
authors.initials: S
authors.lastname: Hu
mesh_terms: D000368:Aged; D045744:Cell Line, Tumor; D002465:Cell Movement; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D015854:Up-Regulation; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C485671:BAMBI protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; D051176:beta Catenin