title: Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors.
abstract: OBJECTIVE
  We sought to quantify the proportion of uterine cancer survivors who self-report poor physical function. We then sought to quantify the association of poor physical function with physical activity (PA), walking, and lower limb lymphedema (LLL), among women with a history of uterine cancer.
  
  
  METHODS
  Physical function was quantified using the Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) questionnaire. PA, walking, and LLL were measured using self-report questionnaire. PA was calculated using metabolic equivalent hours per week (MET-h week(-1)), and walking was calculated using blocks per day (blocks day(-1)). Logistic regression estimated odds ratios (OR) and 95 % confidence intervals (95 % CI).
  
  
  RESULTS
  Among the 213 uterine cancer survivors in our survey (43 % response rate), 35 % self-reported poor physical function. Compared to participants who reported <3.0 MET-h week(-1) of PA, participants who reported ≥18.0 MET-h week(-1) of PA were less likely to have poor physical function (OR 0.03, 95 % CI 0.01-0.10; P trend  < 0.0001). Compared to participants who reported <4.0 blocks day(-1) of walking, participants who reported ≥12.0 blocks day(-1) of walking were less likely to have poor physical function (OR 0.07, 95 % CI 0.03-0.19; P trend  < 0.0001). Compared to participants who did not have LLL, participants with LLL were more likely to have poor physical function (OR 5.25, 95 % CI 2.41-11.41; P < 0.0001).
  
  
  CONCLUSIONS
  Higher levels of PA and walking associate with a lower likelihood of reporting poor physical function. The presence of LLL associates with a higher likelihood of reporting poor physical function. These findings are hypothesis-generating and should be evaluated in future prospective studies.
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, 8th Floor, Blockley Hall, Philadelphia, PA, 19104, USA.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Brown
authors.forename: Lilie L
authors.initials: LL
authors.lastname: Lin
authors.forename: Saya
authors.initials: S
authors.lastname: Segal
authors.forename: Christina S
authors.initials: CS
authors.lastname: Chu
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Haggerty
authors.forename: Emily M
authors.initials: EM
authors.lastname: Ko
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Schmitz
mesh_terms: D005260:Female; D006801:Humans; D007866:Leg; D008209:Lymphedema / Q000503:physiopathology*; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D017741:Survivors; D014594:Uterine Neoplasms / Q000503:physiopathology* / Q000534:rehabilitation*; D016138:Walking / Q000502:physiology*