title: Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier.
abstract: Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification.
authors.affiliation: Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil. ferorsi@unicamp.br.
authors.forename: Fernanda Andrade
authors.initials: FA
authors.lastname: Orsi
authors.forename: Rodrigo Nogueira
authors.initials: RN
authors.lastname: Angerami
authors.forename: Bruna Moraes
authors.initials: BM
authors.lastname: Mazetto
authors.forename: Susan Kelly Picoli
authors.initials: SK
authors.lastname: Quaino
authors.forename: Erich Vinícius
authors.initials: EV
authors.lastname: De Paula
authors.forename: Joyce Maria
authors.initials: JM
authors.lastname: Annichino-Bizzachi
mesh_terms: D000328:Adult; D001938:Brazil; D002199:Capillary Permeability; D003715:Dengue / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D003906:Developing Countries; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D019595:Severe Dengue / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2