title: Analysis of clinical evaluation of response to treatment of Parkinson's disease with integrated Chinese and Western medicine therapy.
abstract: OBJECTIVE
  To analyze the clinical evaluation of Parkinson's disease (PD) patients receiving integrated Chinese and Western medicine therapy.
  
  
  METHODS
  One hundred and twenty patients were enrolled and randomly allocated to a control group or treatment group. Patients in the two groups received placebo and Bushen Huoxue Granule (, BHG), respectively. Both groups received baseline levodopa and benserazide (Madopar). The effects of treatment were assessed monthly during the 9-month treatment. Means of evaluation included Unified PD Rating Scale (UPDRS) scores (II and III), sleep scale score, 10 m turn back test (getting up time, 10 m×2 times, and turning time), timing motor test (TMT)-left and TMT-right, which were treated as the dependent variables; and age, sex, duration of PD, Hoehn and Yahr (H-Y) stage and Madopar dosage of admitted PD patients were as the independent variables. Multiple linear regression was used to analyze these factors.
  
  
  RESULTS
  H-Y stage significantly affected UPDRS II score, UPDRS III score, and getting up time (P<0.01). Madopar dosage and H-Y stage significantly affected the 10 m×2 times (P<0.05 or <0.01). Madopar dosage significantly affected the sleep scale score (P<0.05). There were also significant correlations between age and TMT-left or TMT-right (P<0.01), and duration of PD and TMT-right (P<0.05).
  
  
  CONCLUSIONS
  The six assessed means of clinical evaluation (including UPDRS II and UPDRS III scores, sleep scale score, getting up time, 10 m×2 times, and turning time) are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment.
authors.affiliation: Institute of Chinese Medicine, the General Hospital of the People's Liberation Army, Beijing, 100853, China, kittenlee1115@126.com.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
authors.forename: Jian-Zong
authors.initials: JZ
authors.lastname: Chen
authors.forename: Heng-Jun
authors.initials: HJ
authors.lastname: Shi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D055048:Integrative Medicine; D008297:Male; D008516:Medicine, Chinese Traditional / Q000009:adverse effects; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D012890:Sleep; D013997:Time Factors; D016896:Treatment Outcome