title: Interaction between the SLC19A1 gene and maternal first trimester fever on offspring neural tube defects.
abstract: BACKGROUND
  Many studies have indicated that the reduced folate carrier gene (SLC19A1) is associated with an increased risk of neural tube defects (NTDs). However, the interaction between the SLC19A1 gene variant and maternal fever exposure and NTD risk remains unknown. The aim of this study was to investigate whether the risk for NTDs was influenced by the interactions between the SLC19A1 (rs1051266) variant and maternal first trimester fever.
  
  
  METHODS
  We investigated the potential interaction between maternal first trimester fever and maternal or offspring SLC19A1 polymorphism through a population-based case-control study. One hundred and four nuclear families with NTDs and 100 control families with nonmal newborns were included in the study. SLC19A1 polymorphism was determined using polymerase chain reaction-restricted fragment length polymorphism.
  
  
  RESULTS
  Mothers who had the GG/GA genotype and first trimester fever had an elevated risk of NTDs (adjusted odds ratio, 11.73; 95% confidence interval, 3.02-45.58) as compared to absence of maternal first trimester fever and AA genotype after adjusting for maternal education, paternal education, and age, and had a significant interactive coefficient (γ = 3.17) between maternal GG/GA genotype and first trimester fever. However, there was no interaction between offspring's GG/GA genotype and maternal first trimester fever (the interactive coefficient γ = 0.97) after adjusting for confounding factors.
  
  
  CONCLUSIONS
  Our findings suggested that the risk of NTDs was potentially influenced by a gene-environment interaction between maternal SLC19A1 rs1051266 GG/GA genotype and first trimester fever. Maternal GG/GA genotype may strengthen the effect of maternal fever exposure on NTD risk in this Chinese population.
authors.affiliation: Institute of Population Research, Peking University, Beijing, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Pei
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhu
authors.forename: Rongwei
authors.initials: R
authors.lastname: Ye
authors.forename: Jilei
authors.initials: J
authors.lastname: Wu
authors.forename: Jianmeng
authors.initials: J
authors.lastname: Liu
authors.forename: Aiguo
authors.initials: A
authors.lastname: Ren
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Li
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000235:genetics*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009436:Neural Tube Defects / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011379:Prognosis; D058978:Reduced Folate Carrier Protein / Q000235:genetics*
chemical_list: D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human
keywords: SLC19A1 gene; control study; gene-environment interaction; maternal first trimester fever; neural tube defects; population-based case