title: Mutual interaction between iron homeostasis and obesity pathogenesis.
abstract: Obesity is identified as an important medical problem. One of the pathologic conditions observed in obesity is systemic iron deficiency and hypoferremia. Along with a large number of studies indicating disturbed iron homeostasis in obesity, recent data indicate a cause-effect relationship between iron status and obesity-related pathologies. The primary objective of the article is to consider two aspects of the iron-obesity interplay: (1) the mechanisms leading to impaired iron balance, and (2) the pathways of iron participation in obesity-related pathogenesis. While considering disturbance of iron homeostasis in obesity, a number of potential mechanisms of hypoferremia are proposed. At the same time, the inflammation of obesity and obesity-related hepcidin and lipocalin 2 hyperproduction seem to be the most probable reasons of obesity-related hypoferremia. Oversecretion of these proteins leads to iron sequestration in reticuloendothelial system cells. The latter also leads to increased adipose tissue iron content, thus producing preconditions for adverse effects of local iron overload. Being a redox-active metal, iron is capable of inducing oxidative stress as well as endoplasmic reticulum stress, inflammation and adipose tissue endocrine dysfunction. Iron-mediated mechanisms of toxicity may influence aspects of obesity pathogenesis possibly even leading to obesity aggravation. Thus, a mutual interaction between disturbance in iron homeostasis and obesity pathogenesis is proposed. All sides of this interaction should be considered to design new therapeutic approaches to the treatment of disturbed iron homeostasis in obesity.
authors.affiliation: Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya Street 6, Orenburg 460000, Russia. Electronic address: alalnikonorov@gmail.com.
authors.forename: Alexandr A
authors.initials: AA
authors.lastname: Nikonorov
authors.affiliation: Russian Society of Trace Elements in Medicine, Zemlyanoy Val Street 46, Moscow 105064, Russia.
authors.forename: Margarita G
authors.initials: MG
authors.lastname: Skalnaya
authors.affiliation: Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya Street 6, Orenburg 460000, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
authors.affiliation: Russian Society of Trace Elements in Medicine, Zemlyanoy Val Street 46, Moscow 105064, Russia; Institute of Bioelementology (Russian Satellite Centre of Trace Element - Institute for UNESCO), Orenburg State University, Pobedy Avenue 13, Orenburg 460352, Russia.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D059865:Endoplasmic Reticulum Stress; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D009765:Obesity / Q000209:etiology* / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D007501:Iron
keywords: Adipose tissue; Hypoferremia; Inflammation; Iron; Obesity