title: The morphology of the thumb carpometacarpal joint does not differ between men and women, but changes with aging and early osteoarthritis.
abstract: The high prevalence of thumb carpometacarpal (CMC) joint osteoarthritis (OA) in women has been previously linked to the articular morphology of the trapezium. Studies report conflicting results on how the articular shapes of male and female trapezia compare to one another, however, mainly because their findings are based on data from older cadaveric specimens. The purpose of this in vivo study was to dissociate the effect of sex from that of aging and early OA by using cohorts of healthy young and healthy older subjects, as well as patients with early stage OA. Computed tomography scans from 68 healthy subjects and 87 arthritic subjects were used to obtain 3-D bone models. The trapezial and metacarpal articular surfaces were manually delineated on scaled bone models and compared between sex, age, and health groups by using polar histograms of curvature and average curvatures. We found no sex-related differences, but significant age-group and health-group differences, in the articular surfaces of both bones. Older healthy subjects had higher curvature in the concave and lower curvature in the convex directions of both the trapezial and metacarpal saddles than healthy young subjects. Subjects with early OA had significantly different metacarpal and trapezial articular shapes from healthy subjects of the same age group. These findings suggest that aging and OA affect the articular shape of the CMC joint, but that, in contrast to previously held beliefs, inherent sex differences are not responsible for the higher incidence of CMC OA in women.
authors.affiliation: Center for Biomedical Engineering and School of Engineering, Brown University, Providence, RI 02912, USA.
authors.forename: Eni
authors.initials: E
authors.lastname: Halilaj
authors.affiliation: Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA.
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Moore
authors.affiliation: Department of Computer Science, Brown University, Providence, RI 02912, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Laidlaw
authors.affiliation: Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Got
authors.affiliation: Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA.
authors.forename: Arnold-Peter C
authors.initials: AP
authors.lastname: Weiss
authors.affiliation: Robert A. Chase Hand & Upper Limb Center, Department of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Ladd
authors.affiliation: Center for Biomedical Engineering and School of Engineering, Brown University, Providence, RI 02912, USA; Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA. Electronic address: joseph_crisco@brown.edu.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Crisco
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D052737:Carpometacarpal Joints / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D050279:Metacarpal Bones / Q000503:physiopathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging*; D012737:Sex Factors; D013933:Thumb; D014057:Tomography, X-Ray Computed; D051222:Trapezium Bone; D055815:Young Adult
keywords: Articular joint shape; Computed tomography; Osteoarthritis; Thumb CMC joint; in vivo