title: Use of ossein-hydroxyapatite complex in the prevention of bone loss: a review.
abstract: OBJECTIVE
  The ossein-hydroxyapatite complex (OHC) is a microcrystalline form of calcium which provides a number of additional minerals (magnesium, phosphorus, potassium, zinc), and proteins (osteocalcin, type I collagen, type I insulin growth factor I and II, transforming growth factor beta) associated with bone metabolism. The objective of this review is to examine the role of OHC in preventing bone loss in different conditions.
  
  
  METHODS
  A review of clinical trials assessing the relationship between OHC and bone loss was made using the following data sources: Medline (from 1966 to December 2013), the Cochrane Controlled Clinical Trials Register, Embase (up to December 2013), contact with companies marketing the supplements studied, and reference lists.
  
  
  RESULTS
  Different randomized, clinical trials and meta-analysis suggest that OHC is more effective than calcium supplements in maintaining bone mass in postmenopausal women and in different conditions related to bone loss. In addition, OHC improves pain symptoms and accelerates fracture consolidation in patients with osteopenia or osteoporosis.
  
  
  CONCLUSIONS
  The ossein-hydroxyapatite complex is significantly more effective in preventing bone loss than calcium carbonate.
authors.affiliation: Gynecological Endocrinology Unit, Clinical Institute of Gynecology, Obstetrics & Neonatology, Hospital Clínic i Provincial, School of Medicine, University of Barcelona, and Institut d'Investigació Biomèdica Agust Pi Suñer , Spain.
authors.forename: C
authors.initials: C
authors.lastname: Castelo-Branco
authors.forename: J
authors.initials: J
authors.lastname: Dávila Guardia
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D001847:Bone Diseases / Q000517:prevention & control*; D017886:Durapatite / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D011247:Pregnancy
chemical_list: D050071:Bone Density Conservation Agents; D017886:Durapatite
keywords: BONE MASS; BONE REMODELING; CALCIUM CARBONATE; OSSEIN-HYDROXYAPATITE COMPLEX; OSTEOPOROSIS; OSTEOPOROSIS PREVENTION