title: Chlorpromazine-induced skin pigmentation with corneal and lens opacities.
abstract: Chlorpromazine is known to cause abnormal oculocutaneous pigmentation in sun-exposed areas. We present the case of a psychiatric patient who developed blue-gray pigmentation of the skin as well as corneal and lens opacities following 7 years of chlorpromazine treatment. Ten months after discontinuation of chlorpromazine, the skin discoloration and anterior lens deposits showed partial improvement, but the corneal deposits remained unchanged. A review of the literature on the reversibility of chlorpromazine-induced abnormal oculocutaneous pigmentation also is provided.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Huff
authors.forename: Renata
authors.initials: R
authors.lastname: Prado
authors.forename: Jon F
authors.initials: JF
authors.lastname: Pederson
authors.affiliation: Department of Dermatology, University of Colorado, Denver, 1665 Aurora Ct, PO Box 6510 F703, Aurora, CO 80045, USA. Cory.Dunnick@ucdenver.edu.
authors.forename: Cory A
authors.initials: CA
authors.lastname: Dunnick
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Lucas
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D002746:Chlorpromazine / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D003318:Corneal Opacity / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012559:Schizophrenia / Q000188:drug therapy; D012867:Skin / Q000187:drug effects*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine