title: Antifungal and cytotoxic 2-acylcyclohexane-1,3-diones from Peperomia alata and P. trineura.
abstract: Bioactivity-guided fractionation of the separate CH2Cl2 extracts from the aerial parts of Peperomia alata and P. trineura yielded seven polyketides: alatanone A [3-hydroxy-2-(5'-phenylpent-4'E-enoyl)cyclohex-2-en-1-one, 1a] and alatanone B [3-hydroxy-2-(3'-phenyl-6'-methylenedioxypropanoyl)cyclohex-2-en-1-one, 2a] from P. alata and trineurone A [3-hydroxy-2-(11'-phenylundec-10'E-enoyl)cyclohex-2-en-1-one, 1b], trineurone B [3-hydroxy-2-(15'-phenyl-18'-methylenedioxypentadecanoyl)cyclohex-2-en-1-one, 2b], trineurone C [3-hydroxy-2-(17'-phenyl-20'-methylenedioxyheptadecanoyl)cyclohex-2-en-1-one, 2c], trineurone D [3-hydroxy-2-(hexadec-10'Z-enoyl)cyclohex-2-en-1-one, 3a], and trineurone E [(6R)-(+)-3,6-dihydroxy-2-(hexadec-10'Z-enoyl)cyclohex-2-en-1-one, 3b] from P. trineura. The isolated compounds were evaluated for antifungal activity against Cladosporium cladosporioides and C. sphaeospermum and for cytotoxicity against the K562 and Nalm-6 leukemia cell lines.
authors.affiliation: Research Support Center in Molecular Diversity of Natural Products, Institute of Chemistry, University of São Paulo , 05508-000, São Paulo, SP, Brazil.
authors.forename: Edgard A
authors.initials: EA
authors.lastname: Ferreira
authors.forename: Juliana B
authors.initials: JB
authors.lastname: Reigada
authors.forename: Mauro V
authors.initials: MV
authors.lastname: Correia
authors.forename: Maria C M
authors.initials: MC
authors.lastname: Young
authors.forename: Elsie F
authors.initials: EF
authors.lastname: Guimarães
authors.forename: Gilberto C
authors.initials: GC
authors.lastname: Franchi
authors.forename: Alexandre E
authors.initials: AE
authors.lastname: Nowill
authors.forename: João H G
authors.initials: JH
authors.lastname: Lago
authors.forename: Lydia F
authors.initials: LF
authors.lastname: Yamaguchi
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002963:Cladosporium / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D026321:Piperaceae / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D061065:Polyketides