title: Thyroglobulin antibodies and risk of readmission at one year in subjects with bipolar disorder.
abstract: Thyroid autoimmunity has been proposed as an endophenotype for Bipolar Disorder (BD), although its relationship with clinical outcomes remains unclear. We aimed to determine whether thyroid autoimmune status (thyroperoxidase antibodies [TPO-Abs] and thyroglobulin antibodies [TG-Abs]) in BD is associated with a greater risk for readmission at one year. We studied 77 inpatients with BD admitted for an index manic or mixed episode. Serum thyroid antibodies (TPO-Abs and TG-Abs) were determined at admission. We compared the readmission risk at 1 year, based on patients׳ thyroid autoimmunity profile using survival analyses. Cox regression was used to control covariates. TG-Abs+ but not TPO-Abs+ was associated with a lower risk of relapse. The Kaplan-Meier mean estimated survival times were 341.6 days (CI95% 316.4-366.8) for the TG-Abs+ group and 261.9 days (CI95%: 221.8 to 302.0) for the TG-Abs- group. Cox proportional hazards regression indicated that subjects with TG-Abs+ were 3.7 (1/OR=1/0.27) times less likely to get admitted during the follow-up period than those with TG-Abs-. Our study suggests that an autoimmune biomarker in patients with BD (i.e., the presence of TG-Abs) is associated with a lower risk of psychiatric readmission after an index hospitalization for a manic or mixed episode.
authors.affiliation: Department of Psychiatry, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí-UAB (IUFPT-UAB), Sabadell, Spain. Electronic address: jbarbero@tauli.cat.
authors.forename: Juan D
authors.initials: JD
authors.lastname: Barbero
authors.affiliation: Department of Psychiatry, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí-UAB (IUFPT-UAB), Sabadell, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Garcia-Parés
authors.affiliation: Department of Psychiatry, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí-UAB (IUFPT-UAB), Sabadell, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Llorens
authors.affiliation: Department of Psychiatry, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí-UAB (IUFPT-UAB), Sabadell, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Tost
authors.affiliation: Department of Psychiatry, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí-UAB (IUFPT-UAB), Sabadell, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Cobo
authors.affiliation: Department of Psychiatry, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí-UAB (IUFPT-UAB), Sabadell, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Palao
authors.affiliation: Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, CIBERSAM, Reus, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Labad
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D001714:Bipolar Disorder / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission / Q000706:statistics & numerical data*; D016016:Proportional Hazards Models; D012306:Risk; D013954:Thyroglobulin / Q000097:blood / Q000276:immunology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000906:Antibodies; D001323:Autoantibodies; C006606:anti-thyroglobulin; D013954:Thyroglobulin; D007453:Iodide Peroxidase
keywords: Bipolar Disorder; Outcome; Readmission risk; Thyroglobulin antibodies; Thyroid autoimmunity