title: A novel domino synthesis of quinazolinediones by palladium-catalyzed double carbonylation.
abstract: Combining commercially available bromoanilines and bromobenzonitriles in a novel double carbonylation process allows for a straightforward synthesis of isoindolo[1,2-b]quinazoline-10,12-diones. At least five different CC and/or CN bonds are selectively formed in this 3-component reaction, which likely proceeds through sequential carbonylation-cyclization-isomerisation-carbonylation steps. Notably, two molecules of CO are inserted in this highly efficient palladium-catalyzed process.
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert-Einstein-Strasse 29a, 18059 Rostock (Germany).
authors.forename: Haoquan
authors.initials: H
authors.lastname: Li
authors.forename: Wanfang
authors.initials: W
authors.lastname: Li
authors.forename: Anke
authors.initials: A
authors.lastname: Spannenberg
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Baumann
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D050050:Protein Carbonylation; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D052999:Quinazolinones; D010165:Palladium
keywords: carbonylation; coupling; domino reactions; multicomponent reactions; palladium