title: CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on long-term antiretroviral therapy and correlate with CD8+ T-cell immune activation.
abstract: Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.
authors.affiliation: aImmunology Section, Division of Infectious Diseases, Imperial College Chelsea & Westminster Hospital bHIV & Sexual Health Directorate cDepartment of Gastroenterology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
authors.forename: Louise
authors.initials: L
authors.lastname: Greathead
authors.forename: Rebecca
authors.initials: R
authors.lastname: Metcalf
authors.forename: Brian
authors.initials: B
authors.lastname: Gazzard
authors.forename: Frances
authors.initials: F
authors.lastname: Gotch
authors.forename: Alan
authors.initials: A
authors.lastname: Steel
authors.forename: Peter
authors.initials: P
authors.lastname: Kelleher
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D003106:Colon / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology*
chemical_list: D044966:Anti-Retroviral Agents; C527203:KLRB1 protein, human; D055651:NK Cell Lectin-Like Receptor Subfamily B