title: Artificial liver.
abstract: Artificial liver generally is classified as either inert or cell-based, although only the latter is a true artificial liver. Despite some major achievements and investment, no device is currently available; devices have either not been tested rigorously, or have failed to meet expectations in clinical trials. A successful device will provide the appropriate level of liver function, but it also must be applied in the appropriate clinical setting. An extracorporeal device may be capable of supporting a failing liver, but it will not correct portal hypertension. The future of this field depends on both the technical aspects of the device(s) and their application to the appropriate clinical situation.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, Texas. Electronic address: normans@bcm.edu.
authors.forename: Norman L
authors.initials: NL
authors.lastname: Sussman
authors.affiliation: Cell Machines, Inc, Houston, Texas.
authors.forename: James H
authors.initials: JH
authors.lastname: Kelly
mesh_terms: D035843:Biomedical Research / Q000639:trends*; D006801:Humans; D017093:Liver Failure / Q000628:therapy*; D019164:Liver, Artificial
keywords: Acute Liver Failure; Artificial Liver; Bioartificial Liver; Extracorporeal Liver Assist Device