title: Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology.
abstract: Image quantification studies in positron emission tomography/computed tomography (PET/CT) are of immense importance in the diagnosis and follow-up of variety of cancers. In this review we have described the current image quantification methodologies employed in (18)F-fluorodeoxyglucose ((18)F-FDG) PET in major oncological conditions with particular emphasis on tumor heterogeneity studies. We have described various quantitative parameters being used in PET image analysis. The main contemporary methodology is to measure tumor metabolic activity; however, analysis of other image-related parameters is also increasing. Primarily, we have identified the existing role of tumor heterogeneity studies in major cancers using (18)F-FDG PET. We have also described some newer radiopharmaceuticals other than (18)F-FDG being studied/used in the management of these cancers. Tumor heterogeneity studies are being performed in almost all major oncological conditions using (18)F-FDG PET. The role of these studies is very promising in the management of these conditions.
authors.affiliation: Fellowship of Koh Chang Soon Program, Seoul National University College of Medicine, Seoul, Korea ; Department of Nuclear Medicine, Multan Institute of Nuclear Medicine and Radiotherapy, Nishtar Medical College and Hospital, Multan, Pakistan ; Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehangro, Jongno-gu, Seoul 110-744 Korea.
authors.forename: Muhammad Kashif
authors.initials: MK
authors.lastname: Rahim
authors.affiliation: Elective Course of Medical Education Program, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Elective Course of Medical Education Program, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyeongryul
authors.initials: H
authors.lastname: So
authors.affiliation: Elective Course of Medical Education Program, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehangro, Jongno-gu, Seoul 110-744 Korea.
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehangro, Jongno-gu, Seoul 110-744 Korea.
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehangro, Jongno-gu, Seoul 110-744 Korea.
authors.forename: Keon Wook
authors.initials: KW
authors.lastname: Kang
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehangro, Jongno-gu, Seoul 110-744 Korea.
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
keywords: Positron emission tomography; Quantification; Standard uptake value; Textural analysis; Tumor heterogeneity studies