title: Multicomponent reaction for the first synthesis of 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines as scaffolds for various 3,4-dihydro-2H-1,3-thiazine derivatives.
abstract: A two-step sequence for the synthesis of various 3,4-dihydro-2H-1,3-thiazines is presented. In the first step, 2H-1,3-thiazines were prepared by a new multicomponent reaction (MCR). Starting from β-chlorovinyl aldehydes, this MCR offers an efficient and facile access to 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines. The potential of these products in subsequent reactions was verified by the conversion to 3,4-dihydro-2H-1,3-thiazine-containing bisamides, β-lactams, and methoxy amides.
authors.affiliation: Institut für Chemie, Carl von Ossietzky Universität Oldenburg, P. O. Box 2503, Carl-von-Ossietzky-Str. 9-11, 26111 Oldenburg, Germany. juergen.martens@uni-oldenburg.de.
authors.forename: Fabian
authors.initials: F
authors.lastname: Brockmeyer
authors.forename: Robin
authors.initials: R
authors.lastname: Schoemaker
authors.forename: Marc
authors.initials: M
authors.lastname: Schmidtmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Martens
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D013843:Thiazines / Q000138:chemical synthesis*; D047090:beta-Lactams / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000577:Amides; D013843:Thiazines; D047090:beta-Lactams