title: RNA regulatory networks in animals and plants: a long noncoding RNA perspective.
abstract: A recent highlight of genomics research has been the discovery of many families of transcripts which have function but do not code for proteins. An important group is long noncoding RNAs (lncRNAs), which are typically longer than 200 nt, and whose members originate from thousands of loci across genomes. We review progress in understanding the biogenesis and regulatory mechanisms of lncRNAs. We describe diverse computational and high throughput technologies for identifying and studying lncRNAs. We discuss the current knowledge of functional elements embedded in lncRNAs as well as insights into the lncRNA-based regulatory network in animals. We also describe genome-wide studies of large amount of lncRNAs in plants, as well as knowledge of selected plant lncRNAs with a focus on biotic/abiotic stress-responsive lncRNAs.
authors.forename: Youhuang
authors.initials: Y
authors.lastname: Bai
authors.forename: Xiaozhuan
authors.initials: X
authors.lastname: Dai
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Harrison
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
mesh_terms: D000818:Animals; D001483:Base Sequence; D053263:Gene Regulatory Networks; D016678:Genome / Q000235:genetics; D008954:Models, Biological; D008969:Molecular Sequence Data; D010944:Plants / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D013312:Stress, Physiological / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding
keywords: NAT; RNA regulatory network; lncRNA; miRNA