title: An Intracranial EEG Study of the Neural Dynamics of Musical Valence Processing.
abstract: The processing of valence is known to recruit the amygdala, orbitofrontal cortex, and relevant sensory areas. However, how these regions interact remains unclear. We recorded cortical electrical activity from 7 epileptic patients implanted with depth electrodes for presurgical evaluation while they listened to positively and negatively valenced musical chords. Time-frequency analysis suggested a specific role of the orbitofrontal cortex in the processing of positively valenced stimuli while, most importantly, Granger causality analysis revealed that the amygdala tends to drive both the orbitofrontal cortex and the auditory cortex in theta and alpha frequency bands, during the processing of valenced stimuli. Results from the current study show the amygdala to be a critical hub in the emotion processing network: specifically one that influences not only the higher order areas involved in the evaluation of a stimulus's emotional value but also the sensory cortical areas involved in the processing of its low-level acoustic features.
authors.affiliation: Laboratoire de Neurosciences Fonctionnelles et Pathologies, EA4559, Université Lille-Nord de France, Villeneuve D'Ascq, France Institut du Cerveau et de la Moelle Epinière, Social and Affective Neuroscience Team and Centre MEG-EEG - CENIR, Paris, France Université Pierre et Marie Curie-Paris 6, UMR_S 1127 and Centre MEG-EEG, Paris, France CNRS, UMR 7225 and Centre MEG-EEG, Paris, France.
authors.forename: Diana
authors.initials: D
authors.lastname: Omigie
authors.affiliation: Laboratoire de Neurosciences Fonctionnelles et Pathologies, EA4559, Université Lille-Nord de France, Villeneuve D'Ascq, France Centre National de Référence des Anomalies du Cervelet, CHRU Lille, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Dellacherie
authors.affiliation: Service de Neuroradiologie, Hôpital de la Pitié Salpêtrière, Paris, France Institut du Cerveau et de la Moelle Epinière, Social and Affective Neuroscience Team and Centre MEG-EEG - CENIR, Paris, France Université Pierre et Marie Curie-Paris 6, UMR_S 1127 and Centre MEG-EEG, Paris, France CNRS, UMR 7225 and Centre MEG-EEG, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hasboun
authors.affiliation: Institut du Cerveau et de la Moelle Epinière, Social and Affective Neuroscience Team and Centre MEG-EEG - CENIR, Paris, France Université Pierre et Marie Curie-Paris 6, UMR_S 1127 and Centre MEG-EEG, Paris, France CNRS, UMR 7225 and Centre MEG-EEG, Paris, France Inserm, U 1127 and Centre MEG-EEG, Paris, France ENS, Centre MEG-EEG, Paris, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: George
authors.affiliation: Laboratoire de Neurosciences Fonctionnelles et Pathologies, EA4559, Université Lille-Nord de France, Villeneuve D'Ascq, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Clement
authors.affiliation: Unité D'Epilepsie, Hôpital de la Pitié Salpêtrière, Paris, France Service de Neuroradiologie, Hôpital de la Pitié Salpêtrière, Paris, France Institut du Cerveau et de la Moelle Epinière, Social and Affective Neuroscience Team and Centre MEG-EEG - CENIR, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Baulac
authors.affiliation: Unité D'Epilepsie, Hôpital de la Pitié Salpêtrière, Paris, France Institut du Cerveau et de la Moelle Epinière, Social and Affective Neuroscience Team and Centre MEG-EEG - CENIR, Paris, France Université Pierre et Marie Curie-Paris 6, UMR_S 1127 and Centre MEG-EEG, Paris, France CNRS, UMR 7225 and Centre MEG-EEG, Paris, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Adam
authors.affiliation: Laboratoire de Neurosciences Fonctionnelles et Pathologies, EA4559, Université Lille-Nord de France, Villeneuve D'Ascq, France Unité D'Epilepsie, Hôpital de la Pitié Salpêtrière, Paris, France.
authors.forename: Severine
authors.initials: S
authors.lastname: Samson
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000513:Alpha Rhythm / Q000502:physiology; D000679:Amygdala / Q000503:physiopathology*; D001303:Auditory Cortex / Q000503:physiopathology*; D001307:Auditory Perception / Q000502:physiology; D001931:Brain Mapping; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D009146:Music; D017397:Prefrontal Cortex / Q000503:physiopathology*; D013826:Theta Rhythm / Q000502:physiology; D013997:Time Factors
keywords: ERPs; Granger causality; amygdala; consonance; depth electrodes