title: Matrix-assisted peptide synthesis on nanoparticles.
abstract: We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.
authors.affiliation: Department of Chemistry, Laboratory of Nano-Biomaterials, Bar Ilan University, Ramat Gan, 52900, Israel.
authors.forename: Raz
authors.initials: R
authors.lastname: Khandadash
authors.forename: Victoria
authors.initials: V
authors.lastname: Machtey
authors.forename: Aryeh
authors.initials: A
authors.lastname: Weiss
authors.forename: Gerardo
authors.initials: G
authors.lastname: Byk
mesh_terms: D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques / Q000295:instrumentation / Q000379:methods*
chemical_list: D010455:Peptides
keywords: embedded nanoparticle; magnetic matrix; nanoparticle; peptide; solid phase peptide synthesis