title: Hippocampal representation of related and opposing memories develop within distinct, hierarchically organized neural schemas.
abstract: Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features of events and the locations and contexts in which they occurred. Hippocampal networks developed hierarchical organizations of associated elements of related but separately acquired memories within a context, and distinct organizations for memories where the contexts differentiated object-reward associations. These findings reveal neural mechanisms for the development and organization of relational representations.
authors.affiliation: Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: McKenzie
authors.affiliation: Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Frank
authors.affiliation: Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
authors.forename: Nathaniel R
authors.initials: NR
authors.lastname: Kinsky
authors.affiliation: Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
authors.forename: Blake
authors.initials: B
authors.lastname: Porter
authors.affiliation: Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
authors.forename: Pamela D
authors.initials: PD
authors.lastname: Rivière
authors.affiliation: Center for Memory and Brain, Boston University, Boston, MA 02215, USA. Electronic address: hbe@bu.edu.
authors.forename: Howard
authors.initials: H
authors.lastname: Eichenbaum
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D011897:Random Allocation; D020318:Rats, Long-Evans; D012201:Reward