title: Experimental osteoporosis and its correction.
abstract: Osteoporosis was modeled in rats by chronic (6 months) treatment with omeprazole or serotonin, and bone tissue status was studied in experimental hepatic fibrosis and during serotonin treatment under conditions of hepatic fibrosis. Serum levels of calcium, phosphorus, alkaline phosphatase, albumins, and creatinine and bone tissue levels of calcium, phosphorus, magnesium, and iron were measured. Treatment with mesenchymal stem cells over 6 months reduced the severity of osteoporosis.
authors.affiliation: Central Research Institute of Gastroenterology, Department of Health of Moscow, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Petrakov
authors.forename: V N
authors.initials: VN
authors.lastname: Yarygin
authors.forename: A E
authors.initials: AE
authors.lastname: Lychkov
authors.forename: Yu Yu
authors.initials: YY
authors.lastname: Golubev
authors.forename: A M
authors.initials: AM
authors.lastname: Puzikov
authors.forename: G Yu
authors.initials: GY
authors.lastname: Golubeva
authors.forename: A S
authors.initials: AS
authors.lastname: Melent'ev
mesh_terms: D000418:Albumins / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000097:blood; D002251:Carbon Tetrachloride; D003404:Creatinine / Q000097:blood; D005260:Female; D007501:Iron / Q000378:metabolism; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008274:Magnesium / Q000097:blood; D045164:Mesenchymal Stem Cell Transplantation; D009853:Omeprazole; D010024:Osteoporosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010758:Phosphorus / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D000418:Albumins; D010758:Phosphorus; D012701:Serotonin; D003404:Creatinine; D002251:Carbon Tetrachloride; D007501:Iron; D000469:Alkaline Phosphatase; D008274:Magnesium; D009853:Omeprazole; D002118:Calcium