title: Structure factor model for understanding the measured backscatter coefficients from concentrated cell pellet biophantoms.
abstract: Ultrasonic backscatter coefficient (BSC) measurements were performed on K562 cell pellet biophantoms with cell concentrations ranging from 0.006 to 0.30 in the 10-42 MHz frequency bandwidth. Three scattering models, namely, the fluid-filled sphere model (FFSM), the particle model (PM), and the structure factor model (SFM), were compared for modeling the scattering from an ensemble of concentrated cells. A parameter estimation procedure was developed in order to estimate the scatterer size and relative impedance contrast that could explain the measured BSCs from all the studied cell concentrations. This procedure was applied to the BSC data from K562 cell pellet biophantoms in the 10-42 MHz frequency bandwidth and to the BSC data from Chinese hamster ovary cell pellet biophantoms in the 26-105 MHz frequency bandwidth given in Han, Abuhabsah, Blue, Sarwate, and O'Brien [J. Acoust. Soc. Am. 130, 4139-4147 (2011)]. The data fitting quality and the scatterer size estimates show that the SFM was more suitable than the PM and the FFSM for modeling the responses from concentrated cell pellet biophantoms.
authors.affiliation: Laboratoire de Mécanique et d'Acoustique LMA - CNRS UPR 7051, Aix-Marseille Université, Centrale Marseille, 13402 Marseille Cedex 20, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Franceschini
authors.affiliation: Laboratoire de Mécanique et d'Acoustique LMA - CNRS UPR 7051, Aix-Marseille Université, Centrale Marseille, 13402 Marseille Cedex 20, France.
authors.forename: Régine
authors.initials: R
authors.lastname: Guillermin
authors.affiliation: Laboratoire de Mécanique et d'Acoustique LMA - CNRS UPR 7051, Aix-Marseille Université, Centrale Marseille, 13402 Marseille Cedex 20, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Tourniaire
authors.affiliation: Laboratoire Motricité Humaine Education Sport Santé LAMHESS, Université de Nice Sophia-Antipolis, Nice, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Roffino
authors.affiliation: Laboratoire de Biochimie, Faculté de Pharmacie, Aix-Marseille Université, Marseille, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Lamy
authors.affiliation: Nutrition, Obésité et Risque Thrombotique, UMR INSERM 1062/INRA 1260, Aix-Marseille Université, Marseille, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Landrier