title: Iridium-catalyzed asymmetric hydrogenation of pyrrolo[1,2-a]pyrazinium salts.
abstract: Highly enantioselective iridium-catalyzed hydrogenation of pyrrolo[1,2-a]pyrazinium salts has been achieved, providing a direct access to chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives with up to 95% ee. The key feature of the reaction is the addition of cesium carbonate, which increases the conversion and prohibits the racemization pathway of products.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China.
authors.forename: Wen-Xue
authors.initials: WX
authors.lastname: Huang
authors.forename: Chang-Bin
authors.initials: CB
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D002586:Cesium / Q000737:chemistry; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D012492:Salts
chemical_list: D002254:Carbonates; D011719:Pyrazines; D011758:Pyrroles; D012492:Salts; D002586:Cesium; D007495:Iridium; C545311:cesium carbonate