title: Invasive validation of the Complior Analyse in the assessment of central artery pressure curves: a methodological study.
abstract: BACKGROUND
  Arteries are the target, the place, and the common denominator of cardiovascular diseases; hence, study of arterial function is of greatest importance in clinical practice. The aim of this study was to evaluate the accuracy of carotid pulse wave analysis using the new version of the Complior device--the Complior Analyse.
  
  
  RESULTS
  This was a cross-sectional study that included 15 patients (seven women), mean age 62.07±10.59 years, referenced for cardiac catheterization. Pressure curves were obtained simultaneously in the ascending aorta (invasively) and in the right common carotid artery (using the Complior Analyse). Mean central arterial pressures, augmentation indexes, and wave morphology obtained using both methods were compared. A good concordance between methods was obtained for all the parameters measured, with intraclass correlation coefficients above 0.9. Bland-Altman analysis also indicated a good accuracy profile of the Complior device, with small mean differences observed for all parameters and most values confined within 2 SD of the mean difference. This was further confirmed by the strong Pearson correlation coefficients, with r² coefficients above 0.92 for all the variables studied. The correlations observed were independent of sex, age, arterial pressure, and BMI.
  
  
  CONCLUSIONS
  The results presented and available research clearly indicate that the Complior Analyse device measures carotid pressure waves accurately; therefore, it is a simple and reliable noninvasive alternative for pressure wave analysis.
authors.affiliation: aPolytechnic Institute of Coimbra, ESTES, Department of Cardiopneumology bInstitute of Cardiovascular Research, Coimbra, Portugal.
authors.forename: Telmo
authors.initials: T
authors.lastname: Pereira
authors.forename: João
authors.initials: J
authors.lastname: Maldonado
authors.forename: Rita
authors.initials: R
authors.lastname: Coutinho
authors.forename: Eva
authors.initials: E
authors.lastname: Cardoso
authors.forename: Mafalda
authors.initials: M
authors.lastname: Laranjeiro
authors.forename: Ivo
authors.initials: I
authors.lastname: Andrade
authors.forename: Jorge
authors.initials: J
authors.lastname: Conde
mesh_terms: D000368:Aged; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000295:instrumentation*; D015992:Body Mass Index; D002138:Calibration; D006328:Cardiac Catheterization; D017536:Carotid Artery, Common / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004867:Equipment Design; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D063177:Pulse Wave Analysis / Q000295:instrumentation*