title: Type 1 phototherapeutic agents, part I: preparation and cancer cell viability studies of novel photolabile sulfenamides.
abstract: Novel type 1 phototherapeutic agents based on compounds containing S-N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance spectroscopy. Among the sulfenamides, the most potent compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined in all of the four cancer cell lines.
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Amolkumar S
authors.initials: AS
authors.lastname: Karwa
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Amruta R
authors.initials: AR
authors.lastname: Poreddy
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Bethel
authors.initials: B
authors.lastname: Asmelash
authors.affiliation: Department of Chemistry, Washington University , 1 Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Tien-Sung
authors.initials: TS
authors.lastname: Lin
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Dorshow
authors.affiliation: Covidien Pharmaceuticals , 675 McDonnell Boulevard, Hazelwood, Missouri 63042, United States.
authors.forename: Raghavan
authors.initials: R
authors.lastname: Rajagopalan
keywords: ESR; ROS; Sulfenamides; photosensitizers; radicals; type 1; type 2