title: Biomaterials in cardiovascular research: applications and clinical implications.
abstract: Cardiovascular biomaterials (CB) dominate the category of biomaterials based on the demand and investments in this field. This review article classifies the CB into three major classes, namely, metals, polymers, and biological materials and collates the information about the CB. Blood compatibility is one of the major criteria which limit the use of biomaterials for cardiovascular application. Several key players are associated with blood compatibility and they are discussed in this paper. To enhance the compatibility of the CB, several surface modification strategies were in use currently. Some recent applications of surface modification technology on the materials for cardiovascular devices were also discussed for better understanding. Finally, the current trend of the CB, endothelization of the cardiac implants and utilization of induced human pluripotent stem cells (ihPSCs), is also presented in this review. The field of CB is growing constantly and many new investigators and researchers are developing interest in this domain. This review will serve as a one stop arrangement to quickly grasp the basic research in the field of CB.
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia.
authors.forename: Saravana Kumar
authors.initials: SK
authors.lastname: Jaganathan
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia.
authors.forename: Eko
authors.initials: E
authors.lastname: Supriyanto
authors.affiliation: Rubber Technology Centre, Indian Institute of Technology, Kharagpur, West Bengal 721302, India.
authors.forename: Selvakumar
authors.initials: S
authors.lastname: Murugesan
authors.affiliation: Department of Research and Development, PSNA College of Engineering and Technology, Kothandaraman Nagar, Dindigul, Tamil Nadu 624 622, India.
authors.forename: Arunpandian
authors.initials: A
authors.lastname: Balaji
authors.affiliation: Department of Research and Development, PSNA College of Engineering and Technology, Kothandaraman Nagar, Dindigul, Tamil Nadu 624 622, India.
authors.forename: Manjeesh Kumar
authors.initials: MK
authors.lastname: Asokan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000628:therapy*; D006801:Humans; D019736:Prostheses and Implants; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials