title: Complement system in lung disease.
abstract: In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.
authors.affiliation: 1 Department of Microbiology and Immunology.
authors.forename: Pankita H
authors.initials: PH
authors.lastname: Pandya
authors.forename: David S
authors.initials: DS
authors.lastname: Wilkes
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology* / Q000378:metabolism; D008171:Lung Diseases / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction
chemical_list: D003165:Complement System Proteins
keywords: fibrosis; immune complexes; immunology; transplantation