title: Effect of long-term GH treatment in a patient with CHARGE association.
abstract: CHARGE association is characterized by ocular Coloboma, Heart malformations, choanal Atresia, Retardation of growth and development, Genital abnormalities and inner and external Ear abnormalities. Growth failure is a frequent find mainly associated with feeding difficulties or systemic diseases. To date, GH deficiency has been reported in only few patients with CHARGE association however long-term effects of GH treatment, up to final height, have never been reported. We describe a patient with CHARGE association and GH deficiency treated with GH from the age of 3 years and 10 months up to adult height.
authors.forename: Andrea
authors.initials: A
authors.lastname: Esposito
authors.forename: Maria
authors.initials: M
authors.lastname: Tufano
authors.forename: Iolanda
authors.initials: I
authors.lastname: Di Donato
authors.forename: Martina
authors.initials: M
authors.lastname: Rezzuto
authors.forename: Nicola
authors.initials: N
authors.lastname: Improda
authors.forename: Daniela
authors.initials: D
authors.lastname: Melis
authors.affiliation: Pediatric Section, Department of Medical Translational Sciences, University "Federico II" of Naples, Naples, Italy. salerno@unina.it.
authors.forename: Mariacarolina
authors.initials: M
authors.lastname: Salerno
mesh_terms: D000293:Adolescent; D058747:CHARGE Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D004265:DNA Helicases / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009154:Mutation
chemical_list: D004268:DNA-Binding Proteins; D019382:Human Growth Hormone; D004265:DNA Helicases; C491434:CHD7 protein, human