title: Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies.
abstract: A self-assembled nanoparticle containing a photosensitizer and a Trojan-horse moiety (cholesterol), binds an anti-TB pro-drug and increases 1000-fold its activity against mycobacteria. These minimalist constructs will allow development of economically viable, efficient drug preparations for the treatment of drug-resistant TB infections.
authors.affiliation: Institute of Structural and Molecular Biology and Department of Biological Sciences, School of Science, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK. s.tomas@bbk.ac.uk m.bhatti@ucl.ac.uk.
authors.forename: Manpreet
authors.initials: M
authors.lastname: Bhatti
authors.forename: Timothy D
authors.initials: TD
authors.lastname: McHugh
authors.forename: Lilia
authors.initials: L
authors.lastname: Milanesi
authors.forename: Salvador
authors.initials: S
authors.lastname: Tomas
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019907:Mycobacterium fortuitum / Q000187:drug effects* / Q000502:physiology; D053758:Nanoparticles / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D017319:Photosensitizing Agents; D011355:Prodrugs