title: Effect of rehabilitation program on endocrinological parameters in patients with COPD and in healthy subjects.
abstract: BACKGROUND
  Skeletal muscle wasting commonly occurs in patients with chronic obstructive pulmonary disease (COPD) and has been associated with the presence of systemic inflammation and endocrinological disturbance. The aim of this study is to analyze the effect of rehabilitation program on the balance of anabolic versus catabolic hormone in patients with COPD and in healthy subjects.
  
  
  METHODS
  Nineteen patients with COPD and 16 age-matched healthy subjects undertooked exercise training 3 days/week for 8 weeks. Before and after the training program the concentration of growth hormone (GH), Insulin-Like Growth Factor-1 (IGF-1), Insulin-like Growth Factor-Binding Protein 3 (IGF-BP3), testosterone and cortisol in serum were determined. The exercise measurements included a 6-Minute Walking Test (6MWT).
  
  
  RESULTS
  After 8 weeks, there was no significant change in lung function in patients with COPD and healthy subjects. Growth hormone, Insulin-like Growth Factor-1 and Insulin-like Growth Factor-Binding Protein 3 increased significantly after rehabilitation training (p < 0.01). The rehabilitation program improves the testosterone/cortisol ratio (T/C ratio) in both groups. There is a significant improvement in the 6-Minute Walking distance (6MWD) in both groups (p < 0.01). Dyspnea and heart rate at rest and at the peak of the 6-Minute Walking Test (6MWT) decreased significantly after training program (p < 0.01).
  
  
  CONCLUSIONS
  Pulmonary rehabilitation induces an improvement of the anabolic process and reduces proteine distruction by the modifications in endocrinological factors regulating skeletal muscle in patients with COPD.
authors.affiliation: Department of Physiology and Lung Function Testing, Faculty of Medicine of Sousse, University of Sousse , Tunisia.
authors.forename: Wajdi
authors.initials: W
authors.lastname: Mkacher
authors.forename: Zouhair
authors.initials: Z
authors.lastname: Tabka
authors.forename: Faten
authors.initials: F
authors.lastname: Chaieb
authors.forename: Meriem
authors.initials: M
authors.lastname: Gueddes
authors.forename: Monia
authors.initials: M
authors.lastname: Zaouali
authors.forename: Chirine
authors.initials: C
authors.lastname: Aouichaoui
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: Zbidi
authors.forename: Yassine
authors.initials: Y
authors.lastname: Trabelsi
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004417:Dyspnea / Q000209:etiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D013006:Growth Hormone / Q000097:blood; D006339:Heart Rate; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000503:physiopathology / Q000534:rehabilitation*; D013739:Testosterone / Q000097:blood
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D006854:Hydrocortisone
keywords: Chronic obstructive pulmonary disease; GH/IGF-1/IGF-BP3 axis; Testosterone/Cortisol ratio; pulmonary rehabilitation