title: [Estimation of glomerular filtration rate in adults with common variable immunodeficiency treated with intravenous immunoglobulin. What formula should we use?].
abstract: BACKGROUND
  The common variable immunodeficiency (CVID) is characterized by absence of isohemagglutinins and two standard deviations of normal levels of immunoglobulins. His treatment includes administering immunoglobulin, more frequently intravenous (IVIG). A side effect is the possible severe renal insufficiency secondary to the use of preparations containing sucrose. These patients have weight loss, decreased muscle mass associated with gastrointestinal disorders and bronchiectasis that limit physical activity and other factors. There are different formulas for determining the glomerular filtration rate, we compared the most commonly used to determine the most appropriate in this population.
  
  
  OBJECTIVE
  To determine the correlation between glomerular filtration rate using the MDRD formula, CKD-EPI and Cockcroft-Gault and that obtained through the urine creatinine clearance 24 h in patients with common variable immunodeficiency who are treated with IVIG.
  
  
  METHODS
  A transversal, observational and descriptive study that included 19 patients with common variable immunodeficiency, 12 women and 7 men, mean age 36 years, was done. Descriptive statistics with mean, median, mode and standard deviation was used. To measure the concordance of the measurements for quantitative variables intraclass correlation coefficient was used and to determine the correlation between the stages of renal function with different formulas kappa index was calculated.
  
  
  RESULTS
  The values of the intraclass correlation coefficient showed a good correlation between creatinine clearance in 24 h urine with CKDEPI, mediocre with MDRD and nil with the Cockroft-Gault formula.
  
  
  CONCLUSIONS
  Glomerular filtration rate obtained with CKD-EPI proved to be partially most useful, with a good correlation in relation to urine creatinine clearance in 24 h. Its routine use is recommended over other formulas in common variable immunodeficiency patients with suspected renal disease secondary to the use of IVIG.
authors.affiliation: Servicio de Alergia e Inmunología Clínica, Hospital de Especialidades Dr. Bernardo Sepúlveda. Centro Médico Nacional Siglo XXI, IMSS, México, DF. arturogaspar81@yahoo.com.
authors.forename: Arturo
authors.initials: A
authors.lastname: Gaspar
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Miranda
authors.forename: Eunice
authors.initials: E
authors.lastname: López
authors.forename: Karen
authors.initials: K
authors.lastname: Rodríguez
authors.forename: Nora
authors.initials: N
authors.lastname: Segura
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000188:drug therapy* / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007677:Kidney Function Tests; D008297:Male
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Common variable immunodeficiency; Glomerular filtration rate; Intravenous immunoglobulin