title: HLA-DRB1 and susceptibility to kidney allograft rejection in Southern Iranian patients.
abstract: Kidney transplantation is the best treatment option for the patients with end-stage renal disease. Viral infections and genetic factors such as HLA-II antigens may affect the kidney transplant outcome. The compatibility of HLA-DRB1 molecules in the survival of kidney transplant is important. Also, the correlation between these molecules and viral infections is significant. The current study investigates the allele frequency of HLA-DRB1 in 41 recipient kidney transplant and 203 normal healthy controls by polymerase chain reaction using sequence specific primers. Moreover the relation between HLA-DRB1 allelic groups and hepatitis B, hepatitis C and cytomegalovirus viral infections was also studied. However statistical analysis of the allele frequencies didn't show any significant association between HLA-DRB1 allelic group distributions or sharing and susceptibility to acute kidney transplant rejection (P > 0.05). Comparing the allele frequencies between HLA-DRB1*14 and DRB1*04 allelic showed a significant difference in controls and patients (P = 0.03 and P = 0.05 respectively). The results of the present study also showed a significant association between possession of HLA-DRB1*07 allele in kidney transplant recipients and hepatitis C virus infection (P = 0.009). In conclusion however the results of the present study did not showed relation between HLA-DRB1 allele's frequencies or sharing and kidney transplantation outcome, the results indicated that HLA-DRB1 alleles may susceptible individuals to renal disease or play a role in susceptibility to viral infection in kidney transplant patients.
authors.affiliation: Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Behrouz
authors.initials: B
authors.lastname: Gharesi-Fard
authors.forename: Leila
authors.initials: L
authors.lastname: Rezanezhad
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Karimi
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Salehipour
authors.forename: Seyed Ali Malek
authors.initials: SA
authors.lastname: Hosseini
authors.forename: Jamshid
authors.initials: J
authors.lastname: Roozbeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007492:Iran; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D055815:Young Adult
chemical_list: D059811:HLA-DRB1 Chains