title: The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses.
abstract: PVRL4 (nectin-4) was recently identified as the epithelial receptor for members of the Morbillivirus genus, including measles virus, canine distemper virus and peste des petits ruminants virus. Here, we describe the role of PVRL4 in morbillivirus pathogenesis and its promising use in cancer therapies. This discovery establishes a new paradigm for the spread of virus from lymphocytes to airway epithelial cells and its subsequent release into the environment. Measles virus vaccine strains have emerged as a promising oncolytic platform for cancer therapy in the last ten years. Given that PVRL4 is a well-known tumor-associated marker for several adenocarcinoma (lung, breast and ovary), the measles virus could potentially be used to specifically target, infect and destroy cancers expressing PVRL4.
authors.affiliation: The Department of Microbiology and Immunology, Dalhousie University, Halifax, B3H 1X5 NS, Canada. sebastien.delpeut@dal.ca.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Delpeut
authors.affiliation: The Department of Microbiology and Immunology, Dalhousie University, Halifax, B3H 1X5 NS, Canada. noycer@dal.ca.
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Noyce
authors.affiliation: The Department of Microbiology and Immunology, Dalhousie University, Halifax, B3H 1X5 NS, Canada. chris.richardson@dal.ca.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Richardson
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D008459:Measles virus / Q000502:physiology; D018103:Morbillivirus / Q000502:physiology*; D018185:Morbillivirus Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000502:physiology; D011991:Receptors, Virus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053586:Virus Internalization; D000075983:Nectins
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D011991:Receptors, Virus; C442228:NECTIN4 protein, human; D000075983:Nectins