title: Coasting, embryo development and outcomes of blastocyst transfer: a case-control study.
abstract: This study compared the effect on blastocyst development and clinical outcome of coasting in women at increased risk of moderate-severe ovarian hyperstimulation syndrome (OHSS; n=389) with a control group matched for age and basal FSH that did not undergo coasting (n=386) in IVF/intracytoplasmic sperm injection (ICSI) cycles. The main outcome measures were rate of blastocyst development and live birth. More cycles progressed to the blastocyst stage in the coasted group (n=169) compared with the control group (n=83; 43.4% versus 21.5%; P<0.001). The biochemical pregnancy, clinical pregnancy and live birth rates were similar (46.5% versus 42.0%; 40.6% versus 37.8%; 31.6% versus 30.1%). The duration of coasting up to 4 days did not affect progression to blastocyst stage. The multivariate model showed that coasting (OR 1.73, P=0.004) and the number of oocytes retrieved (OR 1.17, P=0.001) were positively correlated with blastocyst formation. Coasting, a measure to reduce the risk of OHSS, does not impair blastocyst development or clinical outcome. Coasting should remain an effective measure to prevent OHSS.
authors.affiliation: Centre for Reproductive Medicine, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, England, United Kingdom; Department Clinical Sciences, Università Politecnica delle Marche, Via F.Corridoni 11, 60123 Ancona, Italy. Electronic address: solmastalebi@gmail.com.
authors.forename: Solmas
authors.initials: S
authors.lastname: Talebi Chahvar
authors.affiliation: Centre for Reproductive Medicine, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, England, United Kingdom.
authors.forename: Ariel
authors.initials: A
authors.lastname: Zosmer
authors.affiliation: Centre for Reproductive Medicine, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, England, United Kingdom.
authors.forename: Alina
authors.initials: A
authors.lastname: Caragia
authors.affiliation: Neurological Clinic, Università Politecnica delle Marche, Via Conca 71, 60100 Ancona, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Balestrini
authors.affiliation: Centre for Reproductive Medicine, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, England, United Kingdom.
authors.forename: Luca
authors.initials: L
authors.lastname: Sabatini
authors.affiliation: Honorary Clinical Senior Lecturer, Women's Health Research Unit, Barts The London School of Medicine and Dentistry, Queen Mary University, London E1 2AB, United Kingdom.
authors.forename: Andrea Luigi
authors.initials: AL
authors.lastname: Tranquilli
authors.affiliation: Centre for Reproductive Medicine, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, England, United Kingdom; Honorary Clinical Senior Lecturer, Women's Health Research Unit, Barts The London School of Medicine and Dentistry, Queen Mary University, London E1 2AB, United Kingdom; Honoraray Clinical Senior Lecturer, The Department of Primary Care and Public Health, Imperial College, London W6 8RP, England, United Kingdom.
authors.forename: Talha
authors.initials: T
authors.lastname: Al-Shawaf
mesh_terms: D000328:Adult; D001755:Blastocyst; D016022:Case-Control Studies; D004624:Embryo Transfer; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000503:physiopathology; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D005640:Follicle Stimulating Hormone
keywords: IVF; OHSS; blastocysts; coasting; live birth