title: Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing.
abstract: Chimeric peptides composed of arginine-rich RNA-binding and tumor cell-targeting motifs have been employed to condense siRNA to form supramolecular nanoparticles via electrostatic associations and deliver siRNA agents in a tumor cell-specific manner.
authors.affiliation: First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China. zjxu@zju.edu.cn shusenzheng@zju.edu.cn.
authors.forename: Hangxiang
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Haiyang
authors.initials: H
authors.lastname: Xie
authors.forename: Xuyong
authors.initials: X
authors.lastname: Wei
authors.forename: Shengyong
authors.initials: S
authors.lastname: Yin
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.forename: Shusen
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D020868:Gene Silencing; D018014:Gene Transfer Techniques; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000008:administration & dosage*; D034741:RNA, Small Interfering / Q000235:genetics*
chemical_list: D001672:Biocompatible Materials; D034741:RNA, Small Interfering