title: Immunisations in Crohn's disease: who? why? what? when?
abstract: Immunosuppression induced by drugs increase the risk of infections in Crohn's disease (CD) patients. The vaccination rate in CD patients is usually low due to inaccurate information concerning the safety and efficacy of vaccines. Vaccines and immunoglobulins, are artificial ways of protection from common infectious diseases and they have had a major effect on mortality. Herein we detail the need of protection induced by vaccines of measles, varicella, Zoster, papillomavirus, shingles, pneumococcal invasive disease, influenza, hepatitis A and B in CD at diagnosis and during the course of the disease even during immunosuppression periods but with different singularities. Vaccination in CD travellers and the matters related to immunization of household healthy members of immunosuppressed patients are also discussed.
authors.affiliation: Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Portugal; Gastroenterology Department, Faculty of Medicine, Centro Hospitalar S. João, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal. Electronic address: fm@med.up.pt.
authors.forename: F
authors.initials: F
authors.lastname: Magro
authors.affiliation: Department of Infectious Diseases, Faculty of Medicine, Centro Hospitalar S. João, Porto, Portugal; Nephrology Research and Development Unit, University of Porto, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Abreu
mesh_terms: D003140:Communicable Disease Control / Q000379:methods*; D003424:Crohn Disease / Q000188:drug therapy*; D006801:Humans; D007115:Immunization Schedule; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D007166:Immunosuppressive Agents; D014612:Vaccines
keywords: Crohn disease; Efficacy; Immunomodulator medication; Immunosuppression; Inflammatory bowel disease; Risk of infection; Vaccines