title: The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma.
abstract: OBJECTIVE
  Consumption of high-fat foods is one of the major causes of obesity. Physical exercise is a strategy used to counteract obesity. The aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (HFD) on appetite-regulating hormones in rat plasma.
  
  
  METHODS
  TWENTY EIGHT MALE WISTAR RATS WERE RANDOMLY DIVIDED INTO FOUR GROUPS: Control group with standard diet (CSD), endurance training with a standard diet (ESD), control group with high-fat diet (CHFD) and endurance training with high-fat diet (EHFD). Twenty-four hr after the last training session, the blood samples were obtained and analyzed for hormones levels.
  
  
  RESULTS
  The significant increased weight gain and food intake and decreased plasma nesfatin-1 and PYY3-36 levels were observed in CHFD group, while exercise under the HFD antagonized these effects. There were no significant changes in ghrelin, insulin and leptin levels in different groups.
  
  
  CONCLUSIONS
  These results suggest that exercise can prevent fattening effect of HFD. Probably, performing exercise makes a reduction of food intake and weight gain in rat via the increase in nesfatin-1 and PYY levels. However, further studies are necessary to understand the exact mechanisms involved in this field.
authors.affiliation: Department of Human Science, Semnan University, Semnan, Iran.
authors.forename: Rouhollah
authors.initials: R
authors.lastname: Haghshenas
authors.affiliation: Exercise Physiology Research Canter, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mahvash
authors.initials: M
authors.lastname: Jafari
authors.affiliation: Department of Exercise physiology, Faculty of Physical Education and Sports Science, University of Tehran, Tehran, Iran.
authors.forename: Aliasghar
authors.initials: A
authors.lastname: Ravasi
authors.affiliation: Department of Exercise physiology, Faculty of Physical Education and Sports Science, University of Tehran, Tehran, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Kordi
authors.affiliation: Department of Biostatistics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Gilani
authors.affiliation: Sport Science and Physical Education Research Center, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shariatzadeh
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hedayati
authors.affiliation: Exercise Physiology Research Canter, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Rahimi
keywords: Endurance training; Food intake; High fat diet; Peptide hormones