title: Predictors of insulin resistance in pediatric burn injury survivors 24 to 36 months postburn.
abstract: Burn injury is a dramatic event with acute and chronic consequences including insulin resistance. However, factors associated with insulin resistance have not been previously investigated. The purpose of this study was to identify factors associated with long-term insulin resistance in pediatric burn injury survivors. The study sample consisted of 61 pediatric burn injury survivors 24 to 36 months after the burn injury, who underwent an oral glucose tolerance test. To assess insulin resistance, the authors calculated the area under the curve for glucose and insulin. The diagnostic criteria of the American Diabetes Association were used to define individuals with impaired glucose metabolism. Additional data collected include body composition, anthropometric measurements, burn characteristics, and demographic information. The data were analyzed using multivariate linear regression analysis. Approximately 12% of the patients met the criteria for impaired glucose metabolism. After adjusting for possible confounders, burn size, age, and body fat percentage were associated with the area under the curve for glucose (P < .05 for all). Time postburn and lean mass were inversely associated with the area under the curve for glucose (P < .05 for both). Similarly, older age predicted higher insulin area under the curve. The results indicate that a significant proportion of pediatric injury survivors suffer from glucose abnormalities 24 to 36 months postburn. Burn size, time postburn, age, lean mass, and adiposity are significant predictors of insulin resistance in pediatric burn injury survivors. Clinical evaluation and screening for abnormal glucose metabolism should be emphasized in patients with large burns, older age, and survivors with high body fat.
authors.affiliation: From the *Department of Preventative Medicine and Community Health, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston; †Metabolism Unit, Shriners Hospitals for Children, Galveston, Texas; Departments of ‡Psychiatry and ‡Department of Psychiatry, University of Texas Medical Branch, Galveston; §Department of Psychology, Shriners Hospitals for Children, Galveston, Texas; ‖Department of Internal Medicine-Geriatrics, ¶Institute for Translational Sciences, and #Department of Surgery, University of Texas Medical Branch, Galveston; and the **Department of Clinical Research and ††Children's Wellness Center, Shriners Hospitals for Children, Galveston, Texas.
authors.forename: Maria
authors.initials: M
authors.lastname: Chondronikola
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Meyer
authors.forename: Labros S
authors.initials: LS
authors.lastname: Sidossis
authors.forename: Sylvia
authors.initials: S
authors.lastname: Ojeda
authors.forename: Joanna
authors.initials: J
authors.lastname: Huddleston
authors.forename: Pamela
authors.initials: P
authors.lastname: Stevens
authors.forename: Elisabet
authors.initials: E
authors.lastname: Børsheim
authors.forename: Oscar E
authors.initials: OE
authors.lastname: Suman
authors.forename: Celeste C
authors.initials: CC
authors.lastname: Finnerty
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000886:Anthropometry; D002056:Burns / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003710:Demography; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D012307:Risk Factors; D017741:Survivors; D013997:Time Factors; D055815:Young Adult