title: Prognostic value of matrix metalloproteinase-9 in gastric cancer: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of matrix metalloproteinase-9 overexpression on clinical outcome of gastric cancer using a meta-analysis.
  
  
  METHODS
  Relevant studies concerning the association between Matrix metalloproteinase-9 expression and survival of patients with gastric cancer were collected from electronic databases. Hazard ratios (HRs) with 95% confidence intervals (Cls) were calculated to estimate the association. Subgroup analysis was calculated to evaluate potential sources of heterogeneity. Besides, we also assessed the relationship between Matrix metalloproteinase-9 level and relevant clinicopathological parameters by estimating the Odds ratios (ORs) with 95% Cls.
  
  
  RESULTS
  Ten studies with 1,478 patients were included to perform a meta-analysis of the survival results. Pooled HRs indicated that MMP-9 overexpression had a negative impact on the over survival (OS) of patients with gastric cancer (HR = 1.69, 95% Cl: 1.29-2.23, P = 0.00), without significant heterogeneity (chi2 = 14.17, I2 = 36.5%, P = 0.117). Similarly, high level of MMP-9 tended to be correlated with lymph node metastasis (OR = 1.91, 95% Cl: 1.40-2.59, P < 0.05) and presence of vascular invasion (OR = 2.64, 95% CI: 1.52-4.59, P <0.05).
  
  
  CONCLUSIONS
  This meta-analysis shows that Matrix metalloproteinase-9 overexpression is a poor prognostic factor in patients with gastric cancer. However, larger scale and randomized studies are needed to confirm its potential clinical value.
authors.forename: Jiong
authors.initials: J
authors.lastname: Chen
authors.forename: Long-Jiang
authors.initials: LJ
authors.lastname: Chen
authors.forename: Hang-Cheng
authors.initials: HC
authors.lastname: Zhou
authors.forename: Ren-Bao
authors.initials: RB
authors.lastname: Yang
authors.forename: Yin
authors.initials: Y
authors.lastname: Lu
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Xia
authors.forename: Wen
authors.initials: W
authors.lastname: Wu
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Hu
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology*; D016019:Survival Analysis
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9