title: Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos.
abstract: Embryo retention in the fallopian tube is thought to lead to ectopic pregnancy, which is a significant cause of morbidity. Hydrogen sulphide (H2S) is a gaseotransmitter produced mainly by cystathionine-γ-lyase and cystathionine-β-synthase. Here we show that cystathionine-γ-lyase and cystathionine -β-synthase are ubiquitously distributed in human fallopian tube epithelium and that H2S signalling relaxes the spontaneous contraction of the human oviduct. Furthermore, an aberration in H2S signalling, either silenced or enhanced activity induced by pharmacologic or genetic methods, causes embryo retention and developmental delay in the mouse oviduct, which is partly reversed by administration of either GYY4137, a slow-releasing H2S donor, or NaHS. Our findings reveal a new regulatory mechanism for oviductal embryo transport.
authors.affiliation: Department of Physiology, Shandong University School of Medicine, Jinan 250012, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Ning
authors.affiliation: Department of Physiology, Shandong University School of Medicine, Jinan 250012, China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Physiology, Shandong University School of Medicine, Jinan 250012, China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Obstetrics and Gynecology, Second Hospital, Shandong University, Jinan 250012, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Physiology, Shandong University School of Medicine, Jinan 250012, China.
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Physiology, Shandong University School of Medicine, Jinan 250012, China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D003541:Cystathionine beta-Synthase / Q000378:metabolism*; D003542:Cystathionine gamma-Lyase / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D064426:Gasotransmitters / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000378:metabolism*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000378:metabolism*
chemical_list: D064426:Gasotransmitters; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide