title: [Two cases of dabigatran-induced esophageal ulcer indicating the usefulness of drug administration guidance].
abstract: Here we report two cases of dabigatran-induced esophageal ulcer. Case 1 was a 67-year-old man who presented with heartburn that developed a month after dabigatran administration. Case 2 was an 81-year-old woman who presented with epigastralgia that developed within a few days of dabigatran administration. Endoscopic findings were similar in both cases, including shallow esophageal ulcers covered with a thin whitish membrane. The patients were advised to consume the drug with plenty of water during meals and to remain in a sitting position for 30 min after consumption. This method successfully decreased their symptoms and ulcers, indicating that drug administration guidance is extremely effective in managing dabigatran-induced esophageal injury.
authors.affiliation: Department of Gastroenterology, Kagawa Prefectural Central Hospital.
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Inaba
authors.forename: Shou
authors.initials: S
authors.lastname: Mizukawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakakihara
authors.forename: Shigenao
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Miyoshi
authors.forename: Masaki
authors.initials: M
authors.lastname: Wato
authors.forename: Kozo
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000008:administration & dosage* / Q000009:adverse effects*; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000009:adverse effects*; D000069604:Dabigatran; D004935:Esophageal Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D014456:Ulcer / Q000139:chemically induced*; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran