title: Subclinical hypothyroidism represents an additional risk factor for coronary artery calcification, especially in subjects with intermediate and high cardiovascular risk scores.
abstract: OBJECTIVE
  Several studies have suggested an association between subclinical hypothyroidism (SCH) and increased cardiovascular risk. The aim of this study was to evaluate the presence of coronary artery disease (CAD) in asymptomatic patients with SCH by measuring the coronary artery calcium score (CACS).
  
  
  METHODS
  A total of 222 asymptomatic subjects (103 SCH and 119 euthyroid (EU)), who were between the ages of 35 and 65 years and had no previous history of CAD, were enrolled for this cross-sectional analysis.
  
  
  METHODS
  The criteria for SCH included a confirmed normal serum free thyroxine and high TSH levels. Lipid profile, Framingham risk score (FRS) and CACS analyses were performed for all subjects.
  
  
  RESULTS
  The SCH and EU groups were comparable with respect to age, gender, BMI and frequency of diabetes, systemic arterial hypertension, hypercholesterolaemia and smoking. There was no difference in the median CACS between the SCH and EU groups. However, in the subgroup of subjects with intermediate/high FRS (AR10y ≥10%), CACS was higher in the SCH subjects compared with EU subjects (EU vs SCH, 0.0 (57.0) vs 23.0 (161.5); P=0.045). Multivariate analysis revealed that the risk for CACS >100 was independently associated with male gender, age >55 years, and the presence of simultaneous SCH and AR10y ≥10% (OR=87.5 (CI=2.1-3500); P=0.001). Serum TSH was positively correlated with CACS, especially in intermediate/high FRS subjects (rs=0.301, P=0.045).
  
  
  CONCLUSIONS
  It was demonstrated that SCH represents an additional risk factor for CAD, notably in intermediate and high FRS subjects.
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil nathalieaos@gmail.com.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Silva
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Olga
authors.initials: O
authors.lastname: Santos
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: Morais
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, BrazilDivision of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Ilan
authors.initials: I
authors.lastname: Gottlieb
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Macelo
authors.initials: M
authors.lastname: Hadlich
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Tamara
authors.initials: T
authors.lastname: Rothstein
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Milena
authors.initials: M
authors.lastname: Tauil
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Nathalia
authors.initials: N
authors.lastname: Veras
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Mario
authors.initials: M
authors.lastname: Vaisman
authors.affiliation: Division of EndocrinologyCardiovascular ImagingClínica de Diagnósticos por ImagemRadiology ServiceNational Institute of CardiologyRadiology DepartmentRua Rodolpho Paulo Rocco, 255, 9° Andar, Serviço de Endocrinologia, Cidade Universitária, Ilha do Fundão, Rio de Janeiro RJ CEP 21941-913, Brazil.
authors.forename: Patricia de Fátima
authors.initials: Pde F
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood; D061205:Vascular Calcification / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D013972:Thyrotropin