title: Plasma nesfatin-1 levels are increased in patients with polycystic ovary syndrome.
abstract: BACKGROUND
  Nesfatin-1 is a recently discovered neuropeptide derived from its precursor nucleobindin-2 (NUCB2) and has been implicated in the regulation of feeding and energy metabolism. It is located in the brain and also produced at the periphery and present in the plasma. However, its pathophysiological role in humans remains unknown. Polycystic ovary syndrome (PCOS) is commonly presented with obesity, insulin resistance, hyperandrogenemia and hirsutism.
  
  
  OBJECTIVE
  To characterize serum nesfatin-1 levels in PCOS women and determine association of nesfatin-1 with metabolic parameters.
  
  
  METHODS
  It is a cross-sectional study of 55 PCOS and 28 healthy women matched in age, in a university hospital setting. Anthropometric, hormonal, metabolic parameters and nesfatin-1 blood levels were determined.
  
  
  RESULTS
  Nesfatin-1 levels were significantly higher in PCOS group compared with the controls 371.43 ± 2.50 versus 275.55 ± 1.74 pg/mL. Multivariate logistic regression analysis that contains: nesfatin-1, body mass index and homeostasis model assessment index revealed significant correlation of nesfatin-1 with the existence of PCOS (p < 0.05).
  
  
  CONCLUSIONS
  Higher nesfatin-1 levels in PCOS women compared to control group may suggest a possibility that nesfatin-1 may play some role in the PCOS.
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey. esranurademoglu@gmail.com.
authors.forename: Esra Nur
authors.initials: EN
authors.lastname: Ademoglu
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey.
authors.forename: Suheyla
authors.initials: S
authors.lastname: Gorar
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Carlıoglu
authors.affiliation: Department of Internal Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Yazıcı
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey.
authors.forename: Fatma Dilek
authors.initials: FD
authors.lastname: Dellal
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Berberoglu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Akdeniz
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Uysal
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Feridun
authors.initials: F
authors.lastname: Karakurt
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D003430:Cross-Sectional Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007333:Insulin Resistance; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D010044:Outpatient Clinics, Hospital; D010053:Ovary / Q000000981:diagnostic imaging; D050177:Overweight / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism; D011446:Prospective Studies; D015203:Reproducibility of Results; D014421:Turkey; D016216:Ultrasonography, Prenatal; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins