title: Indican from Añil (Indigofera suffruticosa Miller) as an herbal protective agent to the liver.
abstract: OBJECTIVE
  To investigate the antitumor activity of mice bearing sarcoma 180 cell lines treated with indican of Indigofera suffruticosa and the histological and morphometric analysis on the liver of those animals.
  
  
  METHODS
  The mice were divided into 3 groups: Group 1 (G1) and Group 3 (G3) bearing sarcoma 180, and Group 2 (G2) without sarcoma 180. G1 and G2 (controls) were administered saline; G3 was treated with indican (25 mg/kg, i.p.).
  
  
  RESULTS
  The purified indican after subchronic treatment did not significantly reduce the mean volume of sarcoma 180 when compared with control G1. HistopathologicaI and morphometric analysis of the liver of G2 and G3 did not show degenerated areas, compared to. G1 which showed pronounced destruction of the liver architectures.
  
  
  CONCLUSIONS
  The results showed that the inhibition of solid tumor growth was not significant; however, the indican from leaves of I. suffruticosa preserved the liver architectures, suggesting its use as an alternative protective agent of the liver tissue.
authors.forename: Izabela R
authors.initials: IR
authors.lastname: Lima
authors.forename: Jeymesson R C
authors.initials: JR
authors.lastname: Vieira
authors.forename: Ivanise B
authors.initials: IB
authors.lastname: Silva
authors.forename: Roberta M P
authors.initials: RM
authors.lastname: Leite
authors.forename: Maria B S
authors.initials: MB
authors.lastname: Maia
authors.forename: Sônia P
authors.initials: SP
authors.lastname: Leite
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005960:Glucosides / Q000494:pharmacology* / Q000633:toxicity; D029883:Indigofera / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000473:pathology; D008517:Phytotherapy / Q000379:methods*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005960:Glucosides; C066596:indican, plant