title: Topical simvastatin improves the pro-angiogenic and pro-osteogenic properties of bioglass putty in the rat calvaria critical-size model.
abstract: Objective was to describe the effect of bioactive glass putty with and without topical simvastatin on new bone formation in critical-sized defects of rat calvaria. A calvarial bone defect was created in 20 male Wistar rats and filled with bioactive glass alone (n = 10) or combined with simvastatin (n = 10). After 4 weeks, the defects were histomorphometrically evaluated for volume fraction (Vv) of woven bone, vessel density, bioglass quantity, and inflammation. Compared to the bioglass-only group, rats treated with simvastatin had greater Vv of blood vessels (3.3% ± 0.7 vs 1.6% ± 0.1, P = .0002) and new bone (2.3% ± 0.2 vs 1.8% ± 2.5, P = .003). The Vv of the bioglass remnants in the bioglass-only group was higher than in the group treated with simvastatin (2.4% ± 0.08 vs 1.7% ± 0.3, P < .0004). Chronic inflammation was noted in 1 rat from each group. Topical simvastatin seems to improve the pro-angiogenic and pro-osteogenic properties of bioglass putty in rat calvaria critical-size defects without significant inflammation.
authors.affiliation: 1  Department of Oral Pathology and Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Allon
authors.forename: Yakir
authors.initials: Y
authors.lastname: Anavi
authors.forename: Dror M
authors.initials: DM
authors.lastname: Allon
mesh_terms: D000287:Administration, Topical; D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery*; D001857:Bone Matrix / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D002516:Ceramics / Q000627:therapeutic use*; D003094:Collagen; D004195:Disease Models, Animal; D007249:Inflammation / Q000473:pathology; D008297:Male; D010011:Osteocytes / Q000187:drug effects / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D012886:Skull / Q000098:blood supply / Q000187:drug effects / Q000473:pathology
chemical_list: D043925:Angiogenesis Inducing Agents; C022107:Bioglass; D018786:Bone Substitutes; D003094:Collagen; D019821:Simvastatin
keywords: angiogenic; bioglass putty; osteogenic inflammation; rat calvaria; simvastatin