title: Value of ¹⁸F-FDG PET-CT in surveillance of postoperative colorectal cancer patients with various carcinoembryonic antigen concentrations.
abstract: OBJECTIVE
  To evaluate the value of positron emission tomography (PET)/computerized tomography (CT) in surveillance of colorectal cancer (CRC) patients with different carcinoembryonic antigen (CEA) concentrations.
  
  
  METHODS
  One hundred and six postoperative CRC patients who had suspected recurrence or metastasis and received fluorodeoxyglucose (FDG) PET/CT within one week were included in this study. The final diagnosis was confirmed by histological examination or clinical follow-up over at least six months.
  
  
  RESULTS
  The sensitivity, specificity, and accuracy of FDG PET/CT were 95.2%, 82.6%, and 92.5%, and 94.8%, 81.4% and 92.8%, respectively, in the case- and lesion-based analyses. The sensitivity and accuracy of FDG PET/CT significantly differed from CT in both analyses (χ(2) = 8.186, P = 0.004; χ(2) =6.201, P = 0.013; χ(2) =13.445, P = 0.000; χ(2) =11.194, P = 0.001). In the lesion-based analysis, the sensitivity, specificity, and accuracy of FDG PET/CT in the abnormal CEA group were 97.8%, 82.6%, and 95.6%, compared with 81.3%, 80%, and 80.6% for patients with normal CEA levels. In case-based analysis, the sensitivity, specificity, and accuracy of FDG PET/CT were 97.2%, 77.8%, and 95% in abnormal CEA group. Only in lesion-based analysis, the sensitivity and accuracy of FDG PET/CT in the abnormal CEA group were significantly superior to those in the normal CEA group (χ(2) =6.432, P = 0.011; χ(2) =7.837, P = 0.005). FDG PET/CT changed the management in 45.8% of patients with positive scans.
  
  
  CONCLUSIONS
  FDG PET/CT showed superior diagnostic value and is an advisable option in surveillance of postoperative CRC patients with a vague diagnosis.
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Feng
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Zhang
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Man
authors.initials: M
authors.lastname: Hu
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Li
authors.initials: L
authors.lastname: Kong
authors.affiliation: Yan Zhang, Jin-Ming Yu, Graduate school of Tianjin Medical University, Tianjin 300070, China.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D049268:Positron-Emission Tomography; D011184:Postoperative Period; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D002272:Carcinoembryonic Antigen; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Carcinoembryonic antigen; Colorectal cancer; Fluorodeoxyglucose positron emission tomography/computed tomography; Metastasis; Recurrence