title: Effect of supplementary zinc on body mass index, pulmonary function and hospitalization in children with cystic fibrosis.
abstract: Zinc deficiency, which is common in patients with cystic fibrosis (CF), can lead to several complications that may increase the number of hospital admissions in this group of patients. As supplementary zinc can prevent such complications, this study was performed to evaluate the effect of supplementary zinc on body mass index (BMI), forced expiratory volume in one second (FEV1) and number of hospitalizations in CF patients. In this study, 30 children with CF, who were referred to the Digestive Diseases Clinic of the Children's Medical Center in Tehran, were enrolled. Supplementary zinc of 2 mg/kg per day was administered to all patients. Serum level of zinc, alkaline phosphatase, and albumin as well as BMI, FEV1, and number of hospitalizations were compared before and after zinc administration. Height (p<0.001), weight (p<0.001) and BMI (p=0.001) were significantly increased after zinc, while the number of hospitalizations was significantly decreased (p=0.023). In contrast to patients with normal pulmonary function tests who received supplement therapy, BMI was not increased in those with abnormal pulmonary function after supplementary zinc. Supplementary zinc can increase BMI in CF patients, mostly in those with normal pulmonary function. While supplementary zinc may decrease the number of hospitalizations, other factors can also influence the hospitalization number.
authors.affiliation: Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj.
authors.forename: Pedram
authors.initials: P
authors.lastname: Ataee
authors.forename: Mehri
authors.initials: M
authors.lastname: Najafi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Gharagozlou
authors.forename: Majid
authors.initials: M
authors.lastname: Aflatounian
authors.forename: Maryam
authors.initials: M
authors.lastname: Mahmoudi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Khodadad
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Farahmand
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Motamed
authors.forename: Glolam Hossein
authors.initials: GH
authors.lastname: Fallahi
authors.forename: Najmoddin
authors.initials: N
authors.lastname: Kalantari
authors.forename: Habib
authors.initials: H
authors.lastname: Soheili
authors.forename: Vajiheh
authors.initials: V
authors.lastname: Modarresi
authors.forename: Mozhgan Sabbaghian
authors.initials: MS
authors.lastname: Modarresi
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000628:therapy*; D019587:Dietary Supplements; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006760:Hospitalization / Q000639:trends; D006801:Humans; D008297:Male; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D015032:Zinc