title: Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications.
abstract: OBJECTIVE
  Short-term studies show that bariatric surgery causes remission of diabetes. The long-term outcomes for remission and diabetes-related complications are not known.
  
  
  OBJECTIVE
  To determine the long-term diabetes remission rates and the cumulative incidence of microvascular and macrovascular diabetes complications after bariatric surgery.
  
  
  METHODS
  The Swedish Obese Subjects (SOS) is a prospective matched cohort study conducted at 25 surgical departments and 480 primary health care centers in Sweden. Of patients recruited between September 1, 1987, and January 31, 2001, 260 of 2037 control patients and 343 of 2010 surgery patients had type 2 diabetes at baseline. For the current analysis, diabetes status was determined at SOS health examinations until May 22, 2013. Information on diabetes complications was obtained from national health registers until December 31, 2012. Participation rates at the 2-, 10-, and 15-year examinations were 81%, 58%, and 41% in the control group and 90%, 76%, and 47% in the surgery group. For diabetes assessment, the median follow-up time was 10 years (interquartile range [IQR], 2-15) and 10 years (IQR, 10-15) in the control and surgery groups, respectively. For diabetes complications, the median follow-up time was 17.6 years (IQR, 14.2-19.8) and 18.1 years (IQR, 15.2-21.1) in the control and surgery groups, respectively.
  
  
  METHODS
  Adjustable or nonadjustable banding (n = 61), vertical banded gastroplasty (n = 227), or gastric bypass (n = 55) procedures were performed in the surgery group, and usual obesity and diabetes care was provided to the control group.
  
  
  METHODS
  Diabetes remission, relapse, and diabetes complications. Remission was defined as blood glucose <110 mg/dL and no diabetes medication.
  
  
  RESULTS
  The diabetes remission rate 2 years after surgery was 16.4% (95% CI, 11.7%-22.2%; 34/207) for control patients and 72.3% (95% CI, 66.9%-77.2%; 219/303) for bariatric surgery patients (odds ratio [OR], 13.3; 95% CI, 8.5-20.7; P < .001). At 15 years, the diabetes remission rates decreased to 6.5% (4/62) for control patients and to 30.4% (35/115) for bariatric surgery patients (OR, 6.3; 95% CI, 2.1-18.9; P < .001). With long-term follow-up, the cumulative incidence of microvascular complications was 41.8 per 1000 person-years (95% CI, 35.3-49.5) for control patients and 20.6 per 1000 person-years (95% CI, 17.0-24.9) in the surgery group (hazard ratio [HR], 0.44; 95% CI, 0.34-0.56; P < .001). Macrovascular complications were observed in 44.2 per 1000 person-years (95% CI, 37.5-52.1) in control patients and 31.7 per 1000 person-years (95% CI, 27.0-37.2) for the surgical group (HR, 0.68; 95% CI, 0.54-0.85; P = .001).
  
  
  CONCLUSIONS
  In this very long-term follow-up observational study of obese patients with type 2 diabetes, bariatric surgery was associated with more frequent diabetes remission and fewer complications than usual care. These findings require confirmation in randomized trials. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01479452.
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Sjöström
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Jacobson
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Sofie
authors.initials: S
authors.lastname: Ahlin
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Johanna
authors.initials: J
authors.lastname: Andersson-Assarsson
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Åsa
authors.initials: Å
authors.lastname: Anveden
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge.
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Carlsson
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Kristjan
authors.initials: K
authors.lastname: Karason
authors.affiliation: Institute of Surgery, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Lönroth
authors.affiliation: Department of Surgery, University Hospital, Örebro, Sweden.
authors.forename: Ingmar
authors.initials: I
authors.lastname: Näslund
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sjöström
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Taube
authors.affiliation: Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden7Nordic School of Public Health, Gothenburg, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Wedel
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Per-Arne
authors.initials: PA
authors.lastname: Svensson
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Kajsa
authors.initials: K
authors.lastname: Sjöholm
authors.affiliation: Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Lena M S
authors.initials: LM
authors.lastname: Carlsson
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D001786:Blood Glucose; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000601:surgery*; D011446:Prospective Studies; D012008:Recurrence; D013548:Sweden; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D001786:Blood Glucose