title: Permethrin alters adipogenesis in 3T3-L1 adipocytes and causes insulin resistance in C2C12 myotubes.
abstract: Pyrethroids are a class of insecticides structurally derived from the naturally occurring insecticides called pyrethrins. Along with emerging evidence that exposure to insecticides is linked to altered weight gain and glucose homeostasis, exposure to pyrethroids has been linked to altered blood glucose levels in humans. Thus, the purpose of this study was to determine the role of permethrin on lipid and glucose metabolisms. Permethrin was treated to 3T3-L1 adipocytes and C2C12 myoblasts to determine its role in lipid and glucose metabolisms, respectively. Permethrin treatment resulted in increased expression of key markers of adipogenesis and lipogenesis in adipocytes. Permethrin significantly reduced insulin-stimulated glucose uptake in myotubes. This is the first report on the role of permethrin in altered lipid metabolism in adipocytes and impaired glucose homeostasis in myotubes. These results may help elucidate fundamental underlying mechanisms between insecticide exposure, particularly permethrin, and potential risk of developing obesity and its comorbidities.
authors.affiliation: Department of Food Science, University of Massachusetts Amherst, Amherst, MA, 01003, USA. ypark@foodsci.umass.edu.
authors.forename: Jonggun
authors.initials: J
authors.lastname: Kim
authors.forename: Yooheon
authors.initials: Y
authors.lastname: Park
authors.forename: Kyong Sup
authors.initials: KS
authors.lastname: Yoon
authors.forename: J Marshall
authors.initials: JM
authors.lastname: Clark
authors.forename: Yeonhwa
authors.initials: Y
authors.lastname: Park
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000378:metabolism* / Q000473:pathology; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007306:Insecticides / Q000009:adverse effects* / Q000494:pharmacology; D007333:Insulin Resistance; D051379:Mice; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000473:pathology; D026023:Permethrin / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D007306:Insecticides; D026023:Permethrin; D005947:Glucose
keywords: Adipogenesis; Glucose Metabolism; Permethrin; Pyrethroids