title: Pneumococcal serotypes and serogroups causing invasive disease in Pakistan, 2005-2013.
abstract: While pneumococcal conjugate vaccines have been implemented in most countries worldwide, use in Asia has lagged in part because of a lack of data on the amount of disease that is vaccine preventable in the region. We describe pneumococcal serotypes elicited from 111 episodes of invasive pneumococcal disease (IPD) from 2005 to 2013 among children and adults in Pakistan. Seventy-three percent (n = 81) of 111 IPD episodes were cases of meningitis (n = 76 in children 0-15 years and n = 5 among adults). Serotypes were determined by target amplification of DNA extracted from pneumococcal isolates (n = 52) or CSF specimens (n = 59). Serogroup 18 was the most common serogroup causing meningitis in children <5 years, accounting for 21% of cases (n = 13). The 10-valent pneumococcal conjugate vaccine (PCV 10) or PCV10- related serotypes were found in 61% (n = 47) of childhood (age 0-15 years) meningitis episodes. PCV-13 increased this coverage to 63% (one additional serotype 19A; n = 48). Our data indicate that use of PCVs would prevent a large proportion of serious pneumococcal disease.
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan; Department of Pathology and Microbiology, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Shakoor
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Furqan
authors.initials: F
authors.lastname: Kabir
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Asif R
authors.initials: AR
authors.lastname: Khowaja
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Shahida M
authors.initials: SM
authors.lastname: Qureshi
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Fyezah
authors.initials: F
authors.lastname: Jehan
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Farah
authors.initials: F
authors.lastname: Qamar
authors.affiliation: National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, United States of America.
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Whitney
authors.affiliation: Department of Pediatrics and Child Health, the Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Anita K M
authors.initials: AK
authors.lastname: Zaidi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000627:therapeutic use; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000472:pathogenicity; D018074:Vaccines, Conjugate / Q000627:therapeutic use; D055815:Young Adult
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate