title: Effect of hypoxia on porphyrin metabolism in bone marrow mesenchymal stem cells.
abstract: Under hypoxic conditions, aminolevulinic acid-induced accumulation of porphyrin pigments and increase in heme content was observed in bone marrow mesenchymal stem cells. The expression of transferrin receptor CD71 responsible for Fe(2+) transport into the cell was also enhanced. Blockade of porphyrin-transporting protein ABCG2 with fumitremorgin C under conditions of normoxia and hypoxia induced accumulation of porphyrin pigments; in hypoxia, these changes were more pronounced.
authors.affiliation: Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, Minsk, Belarus, Renovacio888@yandex.ru.
authors.forename: A G
authors.initials: AG
authors.lastname: Poleshko
authors.forename: E S
authors.initials: ES
authors.lastname: Lobanok
authors.forename: I D
authors.initials: ID
authors.lastname: Volotovskii
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015687:Cell Hypoxia; D002478:Cells, Cultured; D015870:Gene Expression; D006418:Heme / Q000096:biosynthesis*; D007211:Indoles / Q000494:pharmacology; D017136:Ion Transport / Q000187:drug effects; D007501:Iron / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology*; D011166:Porphyrins / Q000096:biosynthesis*; D051381:Rats; D011990:Receptors, Transferrin / Q000235:genetics / Q000378:metabolism
chemical_list: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; C489249:Abcg2 protein, rat; D007211:Indoles; D011166:Porphyrins; D011990:Receptors, Transferrin; C545564:Tfrc protein, rat; D006418:Heme; D000622:Aminolevulinic Acid; C010522:tryptoquivaline; D007501:Iron; D010100:Oxygen