title: Melatonin does not modify the concentration of different metals in AβPP transgenic mice.
abstract: Metals such as aluminum, iron, copper, and zinc have been implicated in the etiology of certain neurodegenerative disorders. On the other hand, it is well known that citric acid enhances Al absorption through the diet, while melatonin may bind such metals and decrease ROS production. In this study, we determined the concentrations of Al, Cu, Zn, Fe, and Mn in various tissues of Tg2576 Al-treated mice. Female mice and wild type littermates were exposed to 1mg Al/g plus 3.2% of citric acid and melatonin 10mg/kg/day for 15months. At 18months of age, metal concentrations were measured in bone, liver, kidney and spleen, as well as in three brain regions. In the citric plus Al group, Al levels were higher in hippocampus than in cortex and cerebellum, while Al concentration in bone was higher than those in kidney, liver and spleen, The current results show that exposure to Al plus citric acid did not produce relevant changes in metal levels related with genotype. Moreover, co-administration of melatonin with Al did not modify significantly metal concentrations in tissues. The present results do not support that melatonin can diminish Al or Fe concentrations in various tissues.
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, "Rovira i Virgili University", Sant Llorenç 21, 43201 Reus, Catalonia, Spain; Biochemical Unit, "Rovira i Virgili University", Sant Llorenç 21, 43201 Reus, Catalonia, Spain.
authors.forename: Celeste
authors.initials: C
authors.lastname: Di Paolo
authors.affiliation: Biochemical Unit, "Rovira i Virgili University", Sant Llorenç 21, 43201 Reus, Catalonia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Cabré
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, "Rovira i Virgili University", Sant Llorenç 21, 43201 Reus, Catalonia, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Domingo
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, "Rovira i Virgili University", Sant Llorenç 21, 43201 Reus, Catalonia, Spain; Biochemical Unit, "Rovira i Virgili University", Sant Llorenç 21, 43201 Reus, Catalonia, Spain. Electronic address: mariamercedes.gomez@urv.cat.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Gómez
mesh_terms: D000284:Administration, Oral; D000535:Aluminum / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D019343:Citric Acid / Q000494:pharmacology; D003300:Copper / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008345:Manganese / Q000378:metabolism; D008550:Melatonin / Q000008:administration & dosage*; D019216:Metals, Heavy / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D019216:Metals, Heavy; D019343:Citric Acid; D008345:Manganese; D003300:Copper; D000535:Aluminum; D007501:Iron; D015032:Zinc; D008550:Melatonin
keywords: Aluminum; AβPP transgenic mice; Citrate; Dietary exposure; Essential elements; Melatonin