title: Toxicokinetics of seven perfluoroalkyl sulfonic and carboxylic acids in pigs fed a contaminated diet.
abstract: The transfer of a mixture of perfluoroalkyl acids (PFAAs) from contaminated feed into the edible tissues of 24 fattening pigs was investigated. Four perfluoroalkyl sulfonic (PFSAs) and three perfluoroalkyl carboxylic acids (PFCAs) were quantifiable in feed, plasma, edible tissues, and urine. As percentages of unexcreted PFAA, the substances accumulated in plasma (up to 51%), fat, and muscle tissues (collectively, meat 40-49%), liver (under 7%), and kidney (under 2%) for most substances. An exception was perfluorooctanesulfonic acid (PFOS), with lower affinity for plasma (23%) and higher for liver (35%). A toxicokinetic model is developed to quantify the absorption, distribution, and excretion of PFAAs and to calculate elimination half-lives. Perfluorohexanoic acid (PFHxA), a PFCA, had the shortest half-life at 4.1 days. PFSAs are eliminated more slowly (e.g., half-life of 634 days for PFOS). PFAAs in pigs exhibit longer elimination half-lives than in most organisms reported in the literature, but still shorter than in humans.
authors.affiliation: BfR - Federal Institute for Risk Assessment, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
authors.forename: Jorge
authors.initials: J
authors.lastname: Numata
authors.forename: Janine
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: Julian
authors.initials: J
authors.lastname: Adolphs
authors.forename: Susan
authors.initials: S
authors.lastname: Ehlers
authors.forename: Helmut
authors.initials: H
authors.lastname: Schafft
authors.forename: Peter
authors.initials: P
authors.lastname: Fuerst
authors.forename: Christine
authors.initials: C
authors.lastname: Müller-Graf
authors.forename: Monika
authors.initials: M
authors.lastname: Lahrssen-Wiederholt
authors.forename: Matthias
authors.initials: M
authors.lastname: Greiner
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002264:Carboxylic Acids / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D005466:Fluorocarbons / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D005506:Food Contamination; D059022:Food Safety; D006207:Half-Life; D008297:Male; D008460:Meat / Q000032:analysis; D013451:Sulfonic Acids / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D034421:Sus scrofa / Q000378:metabolism*; D066007:Toxicokinetics
chemical_list: D002264:Carboxylic Acids; D005466:Fluorocarbons; D013451:Sulfonic Acids