title: Association of neuropeptide Y gene rs16147 polymorphism with metabolic syndrome in patients with documented coronary artery disease.
abstract: OBJECTIVE
  There have been few epidemiological studies that have investigated genetic susceptibility to cardiovascular risk associated with the prevalence of metabolic syndrome (MetS). Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). Therefore, the aim of this study was to investigate the association between the NPY gene rs16147 polymorphism and the presence of MetS in a well defined group of Iranian subjects with angiographically-defined CAD.
  
  
  METHODS
  A cross-sectional study design was used in which a total of 364 patients were recruited; 143 patients with MetS and 221 without MetS were genotyped using the ARMS-PCR technique. Logistic regression analyses were performed to determine the odds ratios (ORs) for the association of specific genotypes with the presence of MetS and related phenotypes.
  
  
  RESULTS
  The frequency of the variant G allele of the NPY gene was significantly higher in CAD patients without MetS (p = 0.032). Compared to the AA genotype of the NPY gene, individuals carrying the GG genotype had a reduced risk of MetS (OR = 0.51, 95% CI = 0.27-0.95, p = 0.034).
  
  
  CONCLUSIONS
  The rs16147 polymorphism may be associated with presence of MetS among subjects with documented CAD. Carriage of NPY A allele in patients with CAD is associated with a higher prevalence of MetS.
authors.affiliation: Biochemistry of Nutrition Research Center, School of Medicine .
authors.forename: Seyed Alireza
authors.initials: SA
authors.lastname: Parizadeh
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Jamialahmadi
authors.forename: Hassan
authors.initials: H
authors.lastname: Rooki
authors.forename: Houshang
authors.initials: H
authors.lastname: Zaim-Kohan
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Mirhafez
authors.forename: Nedasadat
authors.initials: N
authors.lastname: Hosseini
authors.forename: Javad
authors.initials: J
authors.lastname: Mohiti-Ardakani
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Ali
authors.initials: A
authors.lastname: Masoudi-Kazemabad
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D009478:Neuropeptide Y
keywords: Coronary artery disease; metabolic syndrome; neuropeptide Y gene polymorphism