title: Radiation induced malignant peripheral nerve sheath tumour of the second cervical nerve.
abstract: We report a 44-year-old with progressive quadriparesis due to a dumbbell malignant peripheral nerve sheath tumour (MPNST) of the second cervical nerve, 17 years after whole brain radiotherapy for a pineal germinoma. To our knowledge this is the first case of radiation induced high cervical MPNST arising from a benign neurofibroma.
authors.affiliation: Department of Neurosurgery, Austin Health, The University of Melbourne, 145 Studley Road Heidelberg, VIC 3070, Australia. Electronic address: brydendawes@gmail.com.
authors.forename: Bryden
authors.initials: B
authors.lastname: Dawes
authors.affiliation: Department of Anatomical Pathology, Austin Health, The University of Melbourne, VIC, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clark
authors.affiliation: Department of Neurosurgery, Austin Health, The University of Melbourne, 145 Studley Road Heidelberg, VIC 3070, Australia.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Byrne
authors.affiliation: Department of Anatomical Pathology, Austin Health, The University of Melbourne, VIC, Australia.
authors.forename: Renate
authors.initials: R
authors.lastname: Kalnins
authors.affiliation: Department of Neurosurgery, Austin Health, The University of Melbourne, 145 Studley Road Heidelberg, VIC 3070, Australia.
authors.forename: Augusto
authors.initials: A
authors.lastname: Gonzalvo
authors.affiliation: Department of Neurosurgery, Austin Health, The University of Melbourne, 145 Studley Road Heidelberg, VIC 3070, Australia.
authors.forename: Myron
authors.initials: M
authors.lastname: Rogers
mesh_terms: D000328:Adult; D002572:Cervical Plexus / Q000528:radiation effects*; D016371:Cranial Irradiation / Q000009:adverse effects*; D018237:Germinoma / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D009455:Neurofibroma / Q000150:complications* / Q000209:etiology; D010871:Pinealoma / Q000532:radiotherapy; D011782:Quadriplegia / Q000209:etiology*; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000209:etiology
keywords: Cervical nerve; Dumbbell tumour; Malignant peripheral nerve sheath tumour; Nerve sheath tumour; Radiation therapy