title: Dosimetric comparison of IMRT rectal and anal canal plans generated using an anterior dose avoidance structure.
abstract: To describe a dosimetric method using an anterior dose avoidance structure (ADAS) during the treatment planning process for intensity-modulated radiation therapy (IMRT) for patients with anal canal and rectal carcinomas. A total of 20 patients were planned on the Elekta/CMS XiO treatment planning system, version 4.5.1 (Maryland Heights MO) with a superposition algorithm. For each patient, 2 plans were created: one employing an ADAS (ADAS plan) and the other replanned without an ADAS (non-ADAS plan). The ADAS was defined to occupy the volume between the inguinal nodes and primary target providing a single organ at risk that is completely outside of the target volume. Each plan used the same beam parameters and was analyzed by comparing target coverage, overall plan dose conformity using a conformity number (CN) equation, bowel dose-volume histograms, and the number of segments, daily treatment duration, and global maximum dose. The ADAS and non-ADAS plans were equivalent in target coverage, mean global maximum dose, and sparing of small bowel in low-dose regions (5, 10, 15, and 20 Gy). The mean difference between the CN value for the non-ADAS plans and ADAS plans was 0.04 ± 0.03 (p < 0.001). The mean difference in the number of segments was 15.7 ± 12.7 (p < 0.001) in favor of ADAS plans. The ADAS plan delivery time was shorter by 2.0 ± 1.5 minutes (p < 0.001) than the non-ADAS one. The ADAS has proven to be a powerful tool when planning rectal and anal canal IMRT cases with critical structures partially contained inside the target volume.
authors.affiliation: Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA. Electronic address: bleicher@wpahs.org.
authors.forename: Brian
authors.initials: B
authors.lastname: Leicher
authors.affiliation: Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Day
authors.affiliation: Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA; Drexel University College of Medicine, Allegheny Campus, Philadelphia, PA.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Colonias
authors.affiliation: Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA; Drexel University College of Medicine, Allegheny Campus, Philadelphia, PA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Gayou
mesh_terms: D001005:Anus Neoplasms / Q000532:radiotherapy*; D002277:Carcinoma / Q000532:radiotherapy*; D006801:Humans; D011874:Radiometry; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated
keywords: Conformal dose; Dose avoidance structures; IMRT; Normal tissue sparing