title: Treatment of nongout joint deposition diseases: an update.
abstract: This update develops the actual therapeutic options in the management of the joint involvement of calcium pyrophosphate deposition disease (CPPD), basic calcium phosphate (BCP) deposition disease, hemochromatosis (HH), ochronosis, oxalosis, and Wilson's disease. Conventional pharmaceutical treatment provides benefits for most diseases. Anti-interleukine-1 (IL-1) treatment could provide similar results in CPPD than in gout flares. There is only limited evidence about the efficacy of preventive long-term colchicine intake, methotrexate, and hydroxychloroquine in chronic CPPD. Needle aspiration and lavage have satisfactory short and midterm results in BCP. Extracorporeal shockwave therapy has also proved its efficacy for high-doses regimes. Phlebotomy does not seem to have shown real efficacy on joint involvement in HH so far. Iron chelators' effects have not been assessed on joint involvement either, while IL-1 blockade may prove useful. NSAIDs have limited efficacy on joint involvement of oxalosis, while colchicine and steroids have not been assessed either. The use of nitisinone for ochronotic arthropathy is still much debated, but it could provide beneficial effects on joint involvement. The effects of copper chelators have not been assessed either in the joint involvement of Wilson's disease. NSAIDs should be avoided because of the liver affection they may worsen.
authors.affiliation: Department of Rheumatology, Saint-Philibert Hospital, Service de Rhumatologie, Lille Catholic University, rue du Grand But, 59160 Lomme, France ; Department of Rheumatology, Roger Salengro Hospital, Lille 2 University, rue Emile Laine, 59037 Lille Cedex, France.
authors.forename: Tristan
authors.identifier: 0000-0002-8395-826X
authors.initials: T
authors.lastname: Pascart
authors.affiliation: Federation of Rheumatology, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, UFR Medicale, Paris 7 University, 75475 Paris Cedex 10, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Richette
authors.affiliation: Department of Rheumatology, Roger Salengro Hospital, Lille 2 University, rue Emile Laine, 59037 Lille Cedex, France.
authors.forename: René-Marc
authors.initials: RM
authors.lastname: Flipo