title: Antioxidant and hepatoprotective activity of Veronica ciliata Fisch. extracts against carbon tetrachloride-induced liver injury in mice.
abstract: Veronica ciliata Fisch. has been traditionally used in Traditional Chinese Medicine prescriptions due to its curative effects for hepatitis, cholecystitis, rheumatism, and urticaria. The present study was focused on investigating the role of ethyl acetate and aqueous extracts of Veronica ciliata Fisch. Furthermore, in vitro antioxidant activity (scavenging of DPPH, ABTS, superoxide, and nitrite radicals; reducing power; β-carotene bleaching) and the hepatoprotective effect of the ethyl acetate extract by means of CCl4-induced oxidative stress in mice were investigated. The ethyl acetate extract of Veronica ciliata Fisch. displayed more noteworthy in vitro antioxidant activities than the aqueous extract. Moreover, it signiﬁcantly prevented the increase in serum T-AOC, ALT, AST and ALP level in acute liver damage induced by CCl4, decreased the extent of MDA formation in liver and elevated the activities of SOD and GSH in liver. This activity was found to be comparable to that of bifendate. Histopathological observation of the liver was also performed to further support the evidence from the biochemical analysis. The results indicated that strong antioxidant activities and a signiﬁcant protective effect against acute hepatotoxicity induced by CCl4 of Veronica ciliata Fisch. were concentrated in the ethyl acetate extract. The results suggested that this activity may be due to free radical-scavenging and antioxidant properties.
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China. yinli0130@gmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Yin
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China. yhweilei@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China. furao926@gmail.com.
authors.forename: Rao
authors.initials: R
authors.lastname: Fu
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. dinglisheng613@gmail.com.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Ding
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China. ran@scu.edu.cn.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China. tanglin807@gmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Tang
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China. chenfang232@gmail.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000627:therapeutic use*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D032264:Veronica / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002251:Carbon Tetrachloride