title: Reversible posterior encephalopathy syndrome secondary to sunitinib.
abstract: Reversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Sunitinib is an inhibitor of the vascular endothelial growth factor receptor widely used in the treatment of metastatic renal cell carcinoma (RCC). We report a rare case of RPLS occurring on therapy with sunitinib in a patient with RCC. Our aim is to highlight the importance of considering RPLS as a diagnostic possibility and to hold sunitinib for RCC patients presenting with neurologic symptoms.
authors.affiliation: Department of Oncology, Real Hospital Portugues, 52010 Recife, PE, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Costa
authors.affiliation: Cedar Valley Cancer Center, Waterloo, IA 50701, USA.
authors.forename: Rubens
authors.identifier: 0000-0002-0810-3704
authors.initials: R
authors.lastname: Costa
authors.affiliation: American University of the Caribbean, Coral Gables, FL 33134, USA.
authors.forename: Renata
authors.initials: R
authors.lastname: Costa
authors.affiliation: Department of Radiology, Real Hospital Portugues, 52010 Recife, PE, Brazil.
authors.forename: Gilberto Moura de Brito
authors.initials: GM
authors.lastname: Junior
authors.affiliation: Department of Radiology, Real Hospital Portugues, 52010 Recife, PE, Brazil.
authors.forename: Henrique Queiroz
authors.initials: HQ
authors.lastname: Cartaxo
authors.affiliation: Department of Neurosurgery, Real Hospital Portugues, 52010 Recife, PE, Brazil.
authors.forename: Alex Caetano
authors.initials: AC
authors.lastname: de Barros