title: A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.
abstract: Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle.
authors.affiliation: Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
authors.forename: Marta
authors.initials: M
authors.lastname: Oliveira
authors.forename: Filipa S
authors.initials: FS
authors.lastname: Reis
authors.forename: Diana
authors.initials: D
authors.lastname: Sousa
authors.forename: Catarina
authors.initials: C
authors.lastname: Tavares
authors.forename: Raquel T
authors.initials: RT
authors.lastname: Lima
authors.forename: Isabel C F R
authors.initials: IC
authors.lastname: Ferreira
authors.forename: Tiago
authors.initials: T
authors.lastname: dos Santos
authors.forename: M Helena
authors.initials: MH
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D061986:MCF-7 Cells; D000432:Methanol / Q000378:metabolism; D020940:Reishi / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000378:metabolism; D013552:Swine
chemical_list: D000432:Methanol