title: Single-molecule choreography between telomere proteins and G quadruplexes.
abstract: Telomeric DNA binds proteins to protect chromosome ends, but it also adopts G quadruplex (GQ) structures. Two new studies by Hwang and colleagues (in this issue of Structure) and Ray and colleagues (published elsewhere) use single molecule imaging to reveal how GQs affect the binding of different telomere associated proteins. The data suggest that GQs play important roles in regulating accessibility of telomeres.
authors.affiliation: Department Biochemistry and Gene Center, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Center for Integrated Protein Sciences, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. Electronic address: hopfner@lmb.uni-muenchen.de.
authors.forename: Karl-Peter
authors.initials: KP
authors.lastname: Hopfner
mesh_terms: D006801:Humans; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D019098:Telomerase