title: Essential oil alloaromadendrene from mixed-type Cinnamomum osmophloeum leaves prolongs the lifespan in Caenorhabditis elegans.
abstract: Cinnamomum osmophloeum Kaneh. is an indigenous tree species in Taiwan. The present study investigates phytochemical characteristics, antioxidant activities, and longevity of the essential oils from the leaves of the mixed-type C. osmophloeum tree. We demonstrate that the essential oils from leaves of mixed-type C. osmophloeum exerted in vivo antioxidant activities on Caenorhabditis elegans. In addition, minor (alloaromadendrene, 5.0%) but not major chemical components from the leaves of mixed-type C. osmophloeum have a key role against juglone-induced oxidative stress in C. elegans. Additionally, alloaromadendrene not only acts protective against oxidative stress but also prolongs the lifespan of C. elegans. Moreover, mechanistic studies show that DAF-16 is required for alloaromadendrene-mediated oxidative stress resistance and longevity in C. elegans. The results in the present study indicate that the leaves of mixed-type C. osmophloeum and essential oil alloaromadendrene have the potential for use as a source for antioxidants or treatments to delay aging.
authors.affiliation: Department of Bioenvironmental Systems Engineering, and §Department of Forestry and Resource Conservation, National Taiwan University , Number 1 Roosevelt Road, Section 4, Taipei 106, Taiwan.
authors.forename: Chan-Wei
authors.initials: CW
authors.lastname: Yu
authors.forename: Wen-Hsuan
authors.initials: WH
authors.lastname: Li
authors.forename: Fu-Lan
authors.initials: FL
authors.lastname: Hsu
authors.forename: Pei-Ling
authors.initials: PL
authors.lastname: Yen
authors.forename: Shang-Tzen
authors.initials: ST
authors.lastname: Chang
authors.forename: Vivian Hsiu-Chuan
authors.initials: VH
authors.lastname: Liao
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000302:isolation & purification / Q000493:pharmacokinetics*; D052176:Azulenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000254:growth & development; D027424:Cinnamomum / Q000737:chemistry*; D055808:Drug Discovery; D008136:Longevity / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D016019:Survival Analysis; D013624:Taiwan
chemical_list: D000975:Antioxidants; D052176:Azulenes; D009822:Oils, Volatile; D012717:Sesquiterpenes; C419726:alloaromadendrene
keywords: Caenorhabditis elegans; Cinnamomum osmophloeum; FOXO transcription factor DAF-16; alloaromadendrene; antioxidant; lifespan