title: Short peptides stimulate serotonin expression in cells of brain cortex.
abstract: Peptides Glu-Asp-Arg and Lys-Glu-Asp stimulate serotonin expression in aging cultures of brain cortex cells. Peptide regulation of 5-tryptophan hydroxylase gene encoding the enzyme involved in serotonin synthesis was demonstrated by the molecular docking method. The CCTGCC nucleotide sequence in 5-tryptophan hydroxylase gene was found to be complementary to these peptides. Hence, Glu-Asp-Arg and Lys-Glu-Asp peptides epigenetically regulate serotonin synthesis in the brain cortex, which indicates their neuro- and geroprotective activities.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaya
authors.forename: R S
authors.initials: RS
authors.lastname: Umnov
authors.forename: E V
authors.initials: EV
authors.lastname: Elashkina
authors.forename: A O
authors.initials: AO
authors.lastname: Durnova
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D062105:Molecular Docking Simulation; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D061251:Primary Cell Culture; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000096:biosynthesis* / Q000235:genetics; D018490:Serotonin Agents / Q000494:pharmacology*; D014365:Tryptophan Hydroxylase / Q000235:genetics / Q000378:metabolism
chemical_list: D000697:Central Nervous System Stimulants; D009842:Oligopeptides; D018490:Serotonin Agents; C533570:lysyl-glutamyl-aspartic acid; C570174:pinealon; D012701:Serotonin; D014365:Tryptophan Hydroxylase