title: Serum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney disease.
abstract: BACKGROUND
  Omentin-1, a novel adipokine identified in visceral adipose tissue, is negatively correlated with different conditions such as diabetes, obesity and inflammation. However, changes in serum Omentin levels associated with the degree of the renal dysfunction and metabolic risk factors in CKD patients has not yet been revealed. In the present study, we aimed to investigate the level of Omentin-1 and related para-meters in diabetic and non-diabetic CKD patients.
  
  
  METHODS
  64 (30 diabetic, 34 non-diabetic) CKD patients and 27 healthy control subjects enrolled in this cross-sectional study. Anthropometric and laboratory assessment performed and malnutrition and inflammation components evaluated. Serum concentrations of Omentin-1 and insulin were measured by using ELISA.
  
  
  RESULTS
  Serum Omentin-1 levels in CKD patients were significantly lower compared to the healthy controls. Further analyze revealed that decreased omentin in CKD patients was due to the reduced omentin levels in the diabetic subgroup. An increase in inflammation and malnutrition components was correlated with a decrease in the serum level of Omentin. Omentin levels were lower in stage 2 and 3 CKD but not stage 4 CKD patients compared to control.
  
  
  CONCLUSIONS
  The results of the present study suggest that diabetes mellitus and inflammation should be associated with lower omentin levels in CKD population; however, this reduction resolves due to the failure of degradation and excretion of omentin when creatinine clearance falls below 30 ml/min (stage 4 CKD).
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Tekce
authors.affiliation: Faculty of Medicine, Department of Medical Biochemistry, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: B K
authors.initials: BK
authors.lastname: Tekce
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Aktas
authors.affiliation: Faculty of Medicine, Department of Internal Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Alcelik
authors.affiliation: Department of Nephrology, Derince Education and Research Hospital, Kocaeli, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Sengul
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007249:Inflammation; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D007328:Insulin; D037102:Lectins