title: Candida speciation, antifungal treatment and adverse events in pediatric invasive candidiasis: results from 441 infections in a prospective, multi-national study.
abstract: A multi-national prospective study of pediatric patients with invasive candidiasis between August 2007 and September 2012 was performed and included 441 infections. Variation in infecting Candida species and antifungals used was noted between US and non-US sites. Antifungal-associated adverse events were most common with polyene use.
authors.affiliation: From the *Baylor College of Medicine and Texas Children's Hospital, Houston, TX; †Children's Hospital of Orange County, Orange, CA; ‡Istituto Giannina Gaslini, Genova, Italy; §Monroe Carell Jr. Children's Hospital at Vanderbilt University, Nashville, TN; ¶Children's Hospital of Philadelphia, Philadelphia, PA; and ‖Duke University, Durham, NC.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Palazzi
authors.forename: Antonio
authors.initials: A
authors.lastname: Arrieta
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
authors.forename: Natasha
authors.initials: N
authors.lastname: Halasa
authors.forename: Sydney
authors.initials: S
authors.lastname: Hubbard
authors.forename: Ava A
authors.initials: AA
authors.lastname: Brozovich
authors.forename: Brian T
authors.initials: BT
authors.lastname: Fisher
authors.forename: William J
authors.initials: WJ
authors.lastname: Steinbach
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002175:Candida / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome; D014481:United States
chemical_list: D000935:Antifungal Agents