title: Protein Z G79A polymorphism and puerperal cerebral venous thrombosis.
abstract: Protein Z (PZ), a cofactor for PZ-dependent protease inhibitor, is known to play an important role in inhibiting the coagulation cascade. The aim of the study was to investigate whether PZ G79A polymorphism is a risk factor for puerperal cerebral venous thrombosis (CVT). A total of 71 patients with puerperal CVT and 98 healthy controls were genotyped for PZ 79GA polymorphism by polymerase chain reaction-restriction fragment length polymorphism method. In patients, the genotype distribution for GG, GA, and AA genotypes was 22.5%, 43.7%, and 33.8%, and in controls, 25.5%, 40.8%, and 33.7%, respectively. The risk associated with carrying the mutant genotype (GA and AA) versus the wild GG genotype was found to be 1.11 (95% confidence interval: 0.52-2.35; P = .909). There was no significant difference in the clinical features of the patients with and without the polymorphism. We therefore conclude that PZ G79A polymorphism is not a risk factor for puerperal CVT in Indian women.
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India.
authors.forename: Dharmendrasinh Dhansingh
authors.initials: DD
authors.lastname: Yadav
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India.
authors.forename: Tanima
authors.initials: T
authors.lastname: De
authors.affiliation: Department of Neurology, Dharwad Institute of Mental Health and Neuro Sciences, Dharwad, Karnataka, India.
authors.forename: Dindagur
authors.initials: D
authors.lastname: Nagaraja
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India rita@nimhans.kar.nic.in rita.nimhans@yahoo.com.
authors.forename: Rita
authors.initials: R
authors.lastname: Christopher
mesh_terms: D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007194:India; D020767:Intracranial Thrombosis / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D011644:Puerperal Disorders / Q000235:genetics*
chemical_list: D001798:Blood Proteins; C026080:plasma protein Z
keywords: protein Z; protein Z G79A polymorphism; puerperal cerebral venous thrombosis