title: Recovery of the failing heart: emerging approaches and mechanisms in excitation-contraction coupling.
abstract: Heart failure (HF) is a growing cause of morbidity and mortality globally. All clinical therapies that reduce mortality have been shown to induce reverse remodeling. In this article, we discuss a conceptual approach to the evolving treatment of HF using emerging treatment modalities for the drug-refractory patient. This approach is based on the combinatorial, integrated application of therapies shown to influence reverse remodeling in the laboratory.
authors.affiliation: National Heart and Lung Institute Imperial College London, Imperial College Road, South Kensington, London, SW7 2AZ UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Ibrahim
authors.affiliation: National Heart and Lung Institute Imperial College London, Imperial College Road, South Kensington, London, SW7 2AZ UK.
authors.forename: Joy C E
authors.initials: JC
authors.lastname: Edlin
authors.affiliation: National Heart and Lung Institute Imperial College London, Imperial College Road, South Kensington, London, SW7 2AZ UK.
authors.forename: Anas
authors.initials: A
authors.lastname: Nader
authors.affiliation: National Heart and Lung Institute Imperial College London, Imperial College Road, South Kensington, London, SW7 2AZ UK.
authors.forename: Cesare M N
authors.initials: CM
authors.lastname: Terracciano