title: Pycnogenol ameliorates depression-like behavior in repeated corticosterone-induced depression mice model.
abstract: Oxidative stress is considered to be a mechanism of major depression. Pycnogenol (PYC) is a natural plant extract from the bark of Pinus pinaster Aiton and has potent antioxidant activities. We studied the ameliorative effect of PYC on depression-like behavior in chronic corticosterone- (CORT-) treated mice for 20 days. After the end of the CORT treatment period, PYC (0.2 mg/mL) was orally administered in normal drinking water. Depression-like behavior was investigated by the forced swimming test. Immobility time was significantly longer by CORT exposure. When the CORT-treated mice were supplemented with PYC, immobility time was significantly shortened. Our results indicate that orally administered PYC may serve to reduce CORT-induced stress by radical scavenging activity.
authors.affiliation: School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Mei
authors.affiliation: Kyoto Bunkyo Junior College, 80 Senzoku, Makishima-cho, Uji, Kyoto 611-0041, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Mochizuki
authors.affiliation: Department of Health and Medical Sciences, Ishikawa Prefectural Nursing University, 1-1 Gakuendai, Kahoku, Ishikawa 929-1210, Japan.
authors.forename: Noboru
authors.identifier: 0000-0002-3347-0311
authors.initials: N
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003345:Corticosterone / Q000009:adverse effects*; D003863:Depression / Q000139:chemically induced / Q000188:drug therapy*; D003866:Depressive Disorder / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D013315:Stress, Psychological / Q000188:drug therapy; D013550:Swimming / Q000502:physiology
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; C024070:pycnogenols; D003345:Corticosterone