title: The effects of celiprolol on serum concentrations of proinflammatory cytokines in hypertensive (SHR) and normotensive (WKY) rats.
abstract: BACKGROUND
  A growing body of evidence suggests that some cardiovascular drugs could modulate the level of proinflammatory cytokines. Therefore, the aim of the present study was to investigate whether celiprolol, a third generation β-adrenoceptor blocker, affects lipopolysaccharide (LPS)-induced serum concentrations of TNF-α, IL-1β, IL-6 in normotensive (WKY) and spontaneously hypertensive (SHR) rats.
  
  
  METHODS
  Celiprolol (150 mgkg(-1)) or vehicle was administered by gavage once daily for 21 days. Arterial blood pressure was measured in conscious rats, using the tail-cuff method. Serum concentrations of proinflammatory cytokines were measured with enzyme-linked immunosorbent assay kits. Additionally, plasma concentrations of total cholesterol, HDL-cholesterol and triglycerides were evaluated.
  
  
  RESULTS
  In normotensive WKY rats celiprolol did not affect heart rate, blood pressure, or the serum concentrations of triglycerides, total cholesterol or HDL-cholesterol. In hypertensive animals the drug decreased lipid parameters, increased diastolic and mean blood pressure after the first week of administration, and produced a small but significant decrease in heart rate after the first two weeks of the treatment. In both groups of animals, celiprolol decreased LPS-stimulated serum concentration of IL-6 but did not affect levels of TNF-α and IL-1β.
  
  
  CONCLUSIONS
  It is suggested that the IL-6-modulating properties of celiprolol could provide additional value to the therapeutic effectiveness of the drug in the treatment of hypertension.
authors.affiliation: Department of Pharmacodynamics, Medical University of Lodz, Lodz, Poland. Electronic address: dariusz.andrzejczak@umed.lodz.pl.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Andrzejczak
authors.affiliation: Department of Pharmacodynamics, Medical University of Lodz, Lodz, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Górska
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D017272:Celiprolol / Q000494:pharmacology*; D016207:Cytokines / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D015850:Interleukin-6 / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000959:Antihypertensive Agents; D016207:Cytokines; D015850:Interleukin-6; D008055:Lipids; D017272:Celiprolol
keywords: Celiprolol; Lipids; Proinflammatory cytokines; SHR; WKY