title: Morphology, composition, and bioactivity of strontium-doped brushite coatings deposited on titanium implants via electrochemical deposition.
abstract: Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for use in dental applications. In this study, strontium-doped brushite coatings were deposited on titanium by electrochemical deposition. The phase composition of the coating was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The surface morphologies of the coatings were studied through scanning electron microscopy, and the cytocompatibility and bioactivity of the strontium-doped brushite coatings were evaluated using cultured osteoblasts. Osteoblast proliferation was enhanced by the addition of strontium, suggesting a possible mechanism by which strontium incorporation in brushite coatings increased bone formation surrounding the implants. Cell growth was also strongly influenced by the composition of the deposited coatings, with a 10% Sr-doped brushite coating inducing the greatest amount of bone formation among the tested materials.
authors.affiliation: Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China. lych810@foxmail.com.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Liang
authors.affiliation: College of Stomatology, Hebei United University, Tangshan 063000, China. dingding627@foxmail.com.
authors.forename: Haoyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of stomatology, Tongchuan City People's Hospital, Tongchuan 727000, China. xujiang168@hotmail.com.
authors.forename: Jiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: College of Stomatology, Hebei United University, Tangshan 063000, China. lych810@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Stomatology, Hebei United University, Tangshan 063000, China. haiyang156@foxmail.com.
authors.forename: Mengchun
authors.initials: M
authors.lastname: Qi
authors.affiliation: Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China. humin301@gmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D049109:Cell Proliferation; D015921:Dental Implants; D055664:Electrochemical Techniques; D005260:Female; D008422:Materials Testing; D051379:Mice; D016348:Osseointegration; D010006:Osteoblasts / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013324:Strontium / Q000737:chemistry* / Q000378:metabolism; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants; D014025:Titanium; C494366:calcium phosphate, dibasic, dihydrate; D013324:Strontium