title: Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese.
abstract: OBJECTIVE
  Although microbiota-derived endotoxaemia has previously been shown to induce metabolic disorders, data from population-based longitudinal studies are scarce. This study therefore investigated the associations between lipopolysaccharide binding protein (LBP) levels and 6 year incident metabolic syndrome (MetS), as well as the potentially modifying effects of obesity status in middle-aged and older Chinese men and women.
  
  
  METHODS
  A total of 2,529 men and women aged 50-70 years from Beijing and Shanghai, China, were followed for 6 years. Those free of MetS at baseline (1,312) were included in the analyses for the risk of developing MetS. Baseline plasma LBP was measured using an ELISA kit.
  
  
  RESULTS
  During the 6 year follow-up, 449 (34.2%) participants developed MetS. Baseline LBP was significantly associated with BMI, waist circumference, blood lipid profile and C-reactive protein (CRP) both at baseline and during follow-up (all p < 0.05). The RR for incident MetS comparing extreme quartiles of LBP was 1.28 (95% CI 1.04, 1.58), after multivariate adjustment including BMI and CRP. In stratified analysis, LBP was positively associated with incident MetS only in normal-weight participants (RR, comparing extreme tertiles, 1.59; 95% CI 1.18, 2.15; p(trend)= 0.002), but not in their overweight/obese counterparts (RR, comparing extreme tertiles, 0.99; 95% CI 0.80, 1.22; p(trend) = 0.880). A significant interaction was observed between LBP and obesity status (p(interaction) = 0.013).
  
  
  CONCLUSIONS
  Our study suggested that elevated plasma LBP was associated with an increased risk of developing MetS among middle-aged and older Chinese, especially in normal-weight individuals.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Pang
authors.initials: P
authors.lastname: Yao
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Ma
authors.forename: Feijie
authors.initials: F
authors.lastname: Wang
authors.forename: Qianlu
authors.initials: Q
authors.lastname: Jin
authors.forename: Xingwang
authors.initials: X
authors.lastname: Ye
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D000209:Acute-Phase Proteins; D000367:Age Factors; D000368:Aged; D044466:Asian People; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology*; D011446:Prospective Studies; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein