title: Comparison between percutaneous radiofrequency ablation and surgical hepatectomy focusing on local disease control rate for colorectal liver metastases.
abstract: OBJECTIVE
  Therapeutic efficacy of radiofrequency ablation (RFA) for colorectal liver metastases (CRLM) was compared with hepatic resection (HR), focusing on local disease control rate as well as risk factors of recurrence and patients survival.
  
  
  METHODS
  From April 2002 to March 2012, 32 patients underwent RFA and 60 patients underwent HR for CRLM. The rate of local recurrence along the ablated or resected margin was evaluated in these patients.
  
  
  RESULTS
  The local recurrence was seen in 8 patients (13.3%) after HR, and 15 (46.9%) after RFA. Multivariate analysis of all patients revealed that RFA as an initial therapy (P < 0.001), venous invasion liver metastases (P = 0.049) were independent risk factors for local recurrence. Subgroup analysis showed that local recurrence rate after RFA was significantly higher than that after HR in patients with tumors 20 mm or larger (P < 0.001), while there was no significant difference in local recurrence rate between RFA and HR in patients with tumors less than 20 mm (P = 0.676).
  
  
  CONCLUSIONS
  RFA showed a high risk of local recurrence in comparison to HR especially in patients with tumors larger than 20 mm. Indication of RFA should be restricted drastically considering the limitation of efficacy.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishiwada
authors.forename: Saiho
authors.initials: S
authors.lastname: Ko
authors.forename: Tomohide
authors.initials: T
authors.lastname: Mukogawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsusaka
authors.forename: Toshiya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Eiryo
authors.initials: E
authors.lastname: Kikuchi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis