title: Evaluation of hepatic steatosis using dual-energy CT with MR comparison.
abstract: In this study, we aimed to explore the potential of dual-energy computed tomography (DECT) in evaluating liver fat; we also compared the diagnostic performance of DECT, T1-weighted dual-echo magnetic resonance (MR) imaging, and 1H-MR spectroscopy (1H-MRS) in assessing hepatic steatosis in a fatty liver rat model. Fat (water) concentration measurements by DECT spectral imaging, MR findings, and 1H-MRS measurements of hepatic fat showed similar correlations with the histopathologic results. Furthermore, a good correlation was observed between the fat (water) concentration and 1H-MRS measurements (r = 0.800 and P less than 0.001). The discriminant accuracies of the fat (water) concentration, MR findings, and 1H-MRS measurements were 66.7, 64, and 56 percent, respectively. Therefore, we conclude that the findings of DECT spectral CT imaging are strongly correlated with histopathologic findings in cases of steatosis; in addition, DECT can allow rapid, accurate evaluations of hepatic steatosis that are as effective as those obtained using T1-weighted dual-echo MR imaging and 1H-MRS.
authors.affiliation: China Department of Radiology, Shanghai Ruijin Hospital, No, 197 Ruijin Er Rd, Shanghai, 200011.
authors.forename: Taotao
authors.initials: T
authors.lastname: Sun
authors.affiliation: China Department of Radiology, Shanghai Ruijin Hospital, No, 197 Ruijin Er Rd, Shanghai, 200011.
authors.forename: Xiaozhu
authors.initials: X
authors.lastname: Lin
authors.affiliation: China Department of Radiology, Shanghai Ruijin Hospital, No, 197 Ruijin Er Rd, Shanghai, 200011.
authors.forename: Kemin
authors.initials: K
authors.lastname: Chen
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000175:diagnosis*; D008099:Liver / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D012372:ROC Curve; D017208:Rats, Wistar; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*