title: Management of resistant depression.
abstract: The inadequate assessment and management of depression can lead to the erroneous diagnosis of treatment resistance. After briefly considering the definition and diagnosis of resistant depression, the authors describe the principles and methods of antidepressant therapy, emphasizing the systematic use of medication and the importance of therapeutic drug monitoring. The application of these is then discussed in a clinical context, and illustrated with examples.
authors.affiliation: Geoffrey Knight Unit, Maudsley Hospital, London.
authors.forename: G S
authors.initials: GS
authors.lastname: Malhi
authors.forename: P K
authors.initials: PK
authors.lastname: Bridges
keywords: antidepressants; dose; resistant depression; therapeutic drug monitoring; treatment