title: Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells.
abstract: Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Lombardi
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Honeth
authors.affiliation: Centre de Recherche et Cancérologie, Marseille, Inserm, CRCM, U1068, France ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Ginestier
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Shinomiya
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Marlow
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Bharath
authors.initials: B
authors.lastname: Buchupalli
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Gazinska
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: John
authors.initials: J
authors.lastname: Brown
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Catchpole
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Suling
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Ariel
authors.initials: A
authors.lastname: Barkan
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Max
authors.initials: M
authors.lastname: Wicha
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Anand
authors.initials: A
authors.lastname: Purushotham
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Joy
authors.initials: J
authors.lastname: Burchell
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Pinder
authors.affiliation: Research Oncology, King's College London, London SE1 9RT, UK.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Dontu
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D042361:Mammary Glands, Human / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology*; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*
chemical_list: D019382:Human Growth Hormone; D011374:Progesterone