title: Thermoregulatory modeling for cold stress.
abstract: Modeling for cold stress has generated a rich history of innovation, has exerted a catalytic influence on cold physiology research, and continues to impact human activity in cold environments. This overview begins with a brief summation of cold thermoregulatory model development followed by key principles that will continue to guide current and future model development. Different representations of the human body are discussed relative to the level of detail and prediction accuracy required. In addition to predictions of shivering and vasomotor responses to cold exposure, algorithms are presented for thermoregulatory mechanisms. Various avenues of heat exchange between the human body and a cold environment are reviewed. Applications of cold thermoregulatory modeling range from investigative interpretation of physiological observations to forecasting skin freezing times and hypothermia survival times. While these advances have been remarkable, the future of cold stress modeling is still faced with significant challenges that are summarized at the end of this overview.
authors.affiliation: Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts.
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Xu
authors.forename: Peter
authors.initials: P
authors.lastname: Tikuisis
mesh_terms: D000465:Algorithms; D001833:Body Temperature Regulation; D003080:Cold Temperature / Q000009:adverse effects*; D006801:Humans; D007035:Hypothermia; D008954:Models, Biological