title: [Miraculous catch by neutrophils NETs].
abstract: Neutrophil extracellular traps (NET) account for a new mechanism of anti-infectious innate immunity that may lead to important tissue damages. Indeed, a growing number of studies demonstrate the involvement of NET in the pathogenesis of several human diseases as diverse as autoimmune diseases, thrombotic disorders or some inflammatory diseases. After a short description of molecular mechanisms of NETosis and its host-defense function, we will review their detrimental effects. We will then examine the potential therapeutic approaches for modulating excessive or inappropriate NETosis and thereby minimize tissue injury.
authors.affiliation: Inserm UMR996, faculté de pharmacie, université Paris-Sud 11, 92290 Châtenay-Malabry, France - Département d'hématologie et immunologie, UF auto-immunité et hypersensibilité, hôpital Bichat-Claude Bernard, 75018 Paris, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Granger
authors.affiliation: Inserm UMR996, faculté de pharmacie, université Paris-Sud 11, 92290 Châtenay-Malabry, France - Département d'hématologie et immunologie, UF auto-immunité et hypersensibilité, hôpital Bichat-Claude Bernard, 75018 Paris, France.
authors.forename: Luc
authors.initials: L
authors.lastname: de Chaisemartin
authors.affiliation: Inserm UMR996, faculté de pharmacie, université Paris-Sud 11, 92290 Châtenay-Malabry, France - Département d'hématologie et immunologie, UF auto-immunité et hypersensibilité, hôpital Bichat-Claude Bernard, 75018 Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chollet-Martin
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D005089:Exocytosis / Q000276:immunology; D005110:Extracellular Space / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D013927:Thrombosis / Q000276:immunology