title: Islet cell transplantation.
abstract: Islet transplantation has become a promising treatment for selected patients with type 1 diabetes. Here we provide an overview of the procedure including its history, the process of donor selection, and the techniques and procedures involved in a successful transplant. A brief overview of the current immunosuppressive regimens, the long-term follow-up and the reported outcomes will also be discussed. While islet transplantation is currently generally reserved for adults with type 1 diabetes with severe hypoglycemia or glycemic lability, we herein consider the possibility of its application to the pediatric population.
authors.affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: McCall
authors.affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada; Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada. Electronic address: amjs@islet.ca.
authors.forename: A M James
authors.initials: AM
authors.lastname: Shapiro
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D046148:Donor Selection; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D018579:Patient Selection; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
keywords: Cells; Diabetes; Islets; Pancreas; Transplantation