title: [The anesthesiologic value of transcutaneous acupoint electrical stimulation combined with general intravenous anesthesia in endoscopic thyroidectomy patients: a clinical study].
abstract: OBJECTIVE
  To explore the clinical anesthesia value of transcutaneous acupoint electrical stimulation (TAES) combined with general intravenous anesthesia in endoscopic bilateral thyroidectomy patients.
  
  
  METHODS
  Totally 60 patients who underwent endoscopic bilateral thyroidectomy were equally randomly assigned to 2 groups, the treatment group and the control group, 30 in each group. Patients in the treatment group received TAES combined general intravenous anesthesia, while those in the control group received total intravenous anesthesia. Anesthesia was maintained by target controlled infusion of propofolum combined constant speed infusion of remifentanil in the two groups. TAES was maintained from 30 min before anesthesia induction to the end of endoscopic thyroidectomy at bilateral Hegu (L14) and Neiguan (PC6). The mean artery pressure (MAP) and heart rate (HR) were recorded at different time points of anesthesia, i.e., immediately after entry into the operating room (TO), immediately after intubation (T1), 5 min after intubation (T2), 5 min before incision (T3), 5 min after incision (T4), 30 min after inflation (T5), at the end of surgery (T6), 5 min before extubation (T7), immediately after extubation 0 (T8), and 5 min after extubation (T9). The concentration of IL-6 and TNF-alpha were measured at TO, T3, T5, and T6. The target concentration of propofol was also recorded at T3, T4, and T5.
  
  
  RESULTS
  There was no statistical difference in the operation time between the two groups (P >0.05). Compared with TO in the same group, HR at T3-T4 decreased and increased at T8-T9, and MAP increased at T7-T9 in the treatment group; HR decreased at T3 and increased at T7-T9, MAP increased at T1, T5, T7-T9, and MAP decreased at T2-T3 in the control group. IL-6 increased at T5-T6, while TNF-alpha decreased at T6 in the two groups (P <0.01,P <0.05). Compared with the control group at the same time point, HR decreased at T6-T9, MAP decreased at T1, T4, T5, T7-T9, MAP increased at T3, and IL-6 decreased at T5-T6 in the treatment group (P <0. 05). The concentration and the total amount of propofol were significantly lower in the treatment group than in the control group (P <0.01,P <0.05).
  
  
  CONCLUSIONS
  TAES could maintain the hemodynamics more stably and inhibit the stress response in endoscopic thyroidectomy. It also reduce the dosage of anesthetics and improve the safety of anesthesia.
authors.forename: Yan-Nian
authors.initials: YN
authors.lastname: Yan
authors.forename: Ya-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Wu
authors.forename: Meng-xia
authors.initials: MX
authors.lastname: Wang
mesh_terms: D015669:Acupuncture Points; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D004558:Electric Stimulation / Q000379:methods*; D004724:Endoscopy / Q000379:methods; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D015850:Interleukin-6; D010880:Piperidines; D015742:Propofol; D000077208:Remifentanil; D013965:Thyroidectomy / Q000379:methods*; D004561:Transcutaneous Electric Nerve Stimulation; D014409:Tumor Necrosis Factor-alpha
chemical_list: D015850:Interleukin-6; D010880:Piperidines; D014409:Tumor Necrosis Factor-alpha; D000077208:Remifentanil; D015742:Propofol