title: Cellular microRNAs and picornaviral infections.
abstract: microRNAs (miRNAs) are a subtype of short, endogenous, and non-coding RNAs, which post-transcriptionally regulate gene expression. The miRNA-mediated gene silencing mechanism is involved in a wide spectrum of biological processes, such as cellular proliferation, differentiation, and immune responses. Picornaviridae is a large family of RNA viruses, which includes a number of causative agents of many human and animal diseases viz., poliovirus, foot-and-mouth disease virus (FMDV), and coxsackievirus B3 (CVB3). Accumulated evidences have demonstrated that replication of picornaviruses can be regulated by miRNAs and picornaviral infections can alter the expression of cellular miRNAs. Herein, we outline the intricate interactions between miRNAs and picornaviral infections.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouse Disease Reference Laboratory, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouse Disease Reference Laboratory, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Zeqian
authors.initials: Z
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouse Disease Reference Laboratory, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouse Disease Reference Laboratory, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Yongguang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D035683:MicroRNAs / Q000235:genetics*; D010849:Picornaviridae / Q000502:physiology*; D010850:Picornaviridae Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D014779:Virus Replication
chemical_list: D035683:MicroRNAs
keywords: infection; miRNA; picornavirus