title: [A letal case of gastro-intestinal basidiobolomycosis].
abstract: We report here the case of a 55-year-old man from Mali, who presented with abdominal pain. Radiological exploration revealed an ileo-colonic mass surrounding the appendix. A biopsy was taken and on histology, transmural granulomatous inflammation of numerous eosinophils, lymphocytes, plasmocytes and giant cells was seen. Tuberculosis was suspected clinically and an antibiotic treatment was initiated. Two months later, the patient died of septic complications. Basidiobolus ranarum was identified by PCR. Pathogens were retrospectively highlighted on biopsies. These elements were between 10 and 15 μm in diameter, occasionally pseudo-septated, and were surrounded by a thick eosinophilic cuff. The thick eosinophilic cuff was identified as the Splendore-Hoeppli phenomenon. Basidiobolomycosis is a well-known infection in the tropical areas. Basidiobolus sp., fungus of the order Entomophtorales are a known cause of chronic subcutaneous mycosis. Gastro-intestinal basidiobolomycosis is rare and presents considerable diagnostic difficulty. This infection needs to be diagnosed because surgical resection and prolonged antifungal treatment are curable in most cases.
authors.affiliation: Service d'anatomie pathologique, CHRU Jean-Minjoz, 3, boulevard Fleming, 25000 Besançon cedex, France. Electronic address: arnault.cazorla@free.fr.
authors.forename: Arnault
authors.initials: A
authors.lastname: Cazorla
authors.affiliation: Service de parasitologie, CHRU Jean-Minjoz, 25000 Besançon cedex, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Grenouillet
authors.affiliation: Université de Franche-Comté, 25000 Besançon, France; Service de réanimation, CHRU Jean-Minjoz, 25000 Besançon cedex, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Piton
authors.affiliation: Cabinet de pathologie, 90007 Belfort cedex, France.
authors.forename: Étienne
authors.initials: É
authors.lastname: Faure
authors.affiliation: Université de Franche-Comté, 25000 Besançon, France; Service de radiologie, CHRU Jean-Minjoz, 25000 Besançon cedex, France.
authors.forename: Éric
authors.initials: É
authors.lastname: Delabrousse
authors.affiliation: Service de chirurgie digestive, CHRU Jean-Minjoz, 25000 Besançon cedex, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Mathieu
authors.affiliation: Service d'anatomie pathologique, CHRU Jean-Minjoz, 3, boulevard Fleming, 25000 Besançon cedex, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Viennet
authors.affiliation: Service d'anatomie pathologique, CHRU Jean-Minjoz, 3, boulevard Fleming, 25000 Besançon cedex, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Kantelip
authors.affiliation: Service de parasitologie, CHRU Jean-Minjoz, 25000 Besançon cedex, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Millon
authors.affiliation: Service d'anatomie pathologique, CHRU Jean-Minjoz, 3, boulevard Fleming, 25000 Besançon cedex, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Valmary-Degano
mesh_terms: D001062:Appendectomy; D001064:Appendicitis / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D003092:Colitis / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D057210:Delayed Diagnosis; D003951:Diagnostic Errors; D018450:Disease Progression; D020091:Entomophthorales / Q000302:isolation & purification*; D017809:Fatal Outcome; D006099:Granuloma / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007079:Ileitis / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D007415:Intestinal Obstruction / Q000209:etiology; D008297:Male; D008302:Mali / Q000208:ethnology; D008875:Middle Aged; D012772:Shock, Septic / Q000209:etiology; D014385:Tuberculosis, Gastrointestinal / Q000175:diagnosis; D020096:Zygomycosis / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery
keywords: Basidiobolose; Basidiobolosis; Filaments pseudo-septés; Forme gastro-intestinale; Gastro-intestinal form; Pseudo-septated hyphae; Splendore-Hoeppli