title: [Meta-analysis of safety and efficacy on exercise rehabilitation in coronary heart disease patients post revascularization procedure].
abstract: OBJECTIVE
  To evaluate the safety and efficacy of exercise rehabilitation in coronary heart disease patients post reascularization procedure.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CCRCT), Pubmed, Wanfang, CNKI, CBM and VIP database for randomized controlled trials (RCTs) on exercise rehabilitation for patients with coronary artery disease post percutaneous coronary intervention revascularization or coronary artery bypass grafting. Quality assessment and data collection were conducted by two reviewers independently. The data were analyzed by Review Manager 5.0.
  
  
  RESULTS
  A total of 3 474 patients from 16 RCTs were included in this meta-analysis and patients were divided into exercise rehabilitation group (n = 1 425) and control group (n = 2 049). Meta-analysis results showed mortality rate was similar between the two groups (OR = 0.81, 95%CI 0.38-1.69, P > 0.05) and the incidence of major cardiovascular events rate (OR = 0.40, 95%CI 0.24-0.65, P < 0.01) and heart rate [mean difference (MD) = -2.82, 95%CI -4.72--0.92, P < 0.01] were significantly lower while LVEF (MD = 2.24, 95%CI 0.18-4.31, P < 0.05), the exercise metabolic equivalent (MD = 0.94, 95%CI 0.43-1.44, P < 0.01) , anaerobic threshold (MD = 1.83, 95%CI 0.67-3.00, P < 0.01) , and maximum oxygen consumption (MD = 3.22, 95%CI 2.42-4.03, P < 0.01) were significantly higher in exercise rehabilitation group than in control group.
  
  
  CONCLUSIONS
  Exercise rehabilitation does not increase the risk of mortality in patients of coronary heart disease after revascularization and can effectively reduce major cardiovascular events.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Email: tanghq898@sina.com.
authors.forename: Haiqin
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Zhaoxin
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000534:rehabilitation* / Q000601:surgery; D005081:Exercise Therapy; D006801:Humans; D062645:Percutaneous Coronary Intervention; D016896:Treatment Outcome