title: Wnt-Notch signalling crosstalk in development and disease.
abstract: The Notch and Wnt pathways are two of only a handful of highly conserved signalling pathways that control cell-fate decisions during animal development (Pires-daSilva and Sommer in Nat Rev Genet 4: 39-49, 2003). These two pathways are required together to regulate many aspects of metazoan development, ranging from germ layer patterning in sea urchins (Peter and Davidson in Nature 474: 635-639, 2011) to the formation and patterning of the fly wing (Axelrod et al in Science 271:1826-1832, 1996; Micchelli et al in Development 124:1485-1495, 1997; Rulifson et al in Nature 384:72-74, 1996), the spacing of the ciliated cells in the epidermis of frog embryos (Collu et al in Development 139:4405-4415, 2012) and the maintenance and turnover of the skin, gut lining and mammary gland in mammals (Clayton et al in Nature 446:185-189, 2007; Clevers in Cell 154:274-284, 2013; Doupe et al in Dev Cell 18:317-323, 2010; Lim et al in Science 342:1226-1230, 2013; Lowell et al in Curr Biol 10:491-500, 2000; van et al in Nature 435:959-963, 2005; Yin et al in Nat Methods 11:106-112, 2013). In addition, many diseases, including several cancers, are caused by aberrant signalling through the two pathways (Bolós et al in Endocr Rev 28: 339-363, 2007; Clevers in Cell 127: 469-480, 2006). In this review, we will outline the two signalling pathways, describe the different points of interaction between them, and cover how these interactions influence development and disease.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK, giovanna.collu@mssm.edu.
authors.forename: Giovanna M
authors.initials: GM
authors.lastname: Collu
authors.forename: Ana
authors.initials: A
authors.lastname: Hidalgo-Sastre
authors.forename: Keith
authors.initials: K
authors.lastname: Brennan
mesh_terms: D000818:Animals; D019070:Cell Lineage; D004330:Drosophila / Q000254:growth & development / Q000378:metabolism; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D008322:Mammals / Q000254:growth & development / Q000378:metabolism; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D060449:Wnt Signaling Pathway
chemical_list: D051880:Receptors, Notch