title: Tolerance: one transplant for life.
abstract: Recently, The Transplantation Society convened a workshop to address the question, "What do we need to have in place to make tolerance induction protocols a 'standard of care' for organ transplant recipients over the next decade?" In a productive 2-day meeting, there was wide-ranging discussion on a broad series of topics, resulting in five consensus recommendations as follows: (1) establish a registry of results for patients enrolled in tolerance trials; (2) establish standardized protocols for sample collection and storage; (3) establish standardized biomarkers and assays; (4) include children 12 years and older in protocols that have been validated in adults; and (5) establish a task force to engage third-party payers in discussions of how to fund tolerance trials. Future planned workshops will focus on progress in implementing these recommendations and identifying other steps that the community needs to take.
authors.affiliation: 1 Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Department of Medicine, Northwestern University School of Medicine, Chicago, IL. 3 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 4 Department of Medicine, Stanford University School of Medicine, Palo Alto, CA. 5 Immune Tolerance Network, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 6 Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom. 7 Address correspondence to: Laurence A. Turka, M.D., Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, 149 13th St, Room 5101, Boston, MA 02129.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kawai
authors.forename: Joseph
authors.initials: J
authors.lastname: Leventhal
authors.forename: Joren C
authors.initials: JC
authors.lastname: Madsen
authors.forename: Samuel
authors.initials: S
authors.lastname: Strober
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Turka
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Wood
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002985:Clinical Protocols; D019317:Evidence-Based Medicine; D006084:Graft Rejection / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects / Q000379:methods*; D016377:Organ Transplantation / Q000009:adverse effects*; D012042:Registries; D012307:Risk Factors; D013997:Time Factors; D023001:Transplantation Tolerance; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers