title: [Case of dermatomyositis with anti-CADM-140 antibody and alveolar hemorrhage].
abstract: A-47-year-old woman was admitted to our hospital because of eruption, severe arthritis, myalgia, pharyngalgia and the elevation of serum creatine kinase. She was diagnosed with dermatomyositis based on a biopsied specimen and clinical symptoms. Serum anti CADM-140 antibody was detected by immunoprecipitation. Pulse therapy with methylprednisolone and cyclophophamide could transiently improve myalgia and so on, but she died of rapidly progressive interstitial lung disease. Autopsy findings demonstrated diffuse alveolar damage and alveolar hemorrhage. It is said that patients with anti CADM-140 antibody show poor muscle symptoms and alveolar hemorrhage has been described very rarely. This patient is the rare case of dermatomyositis with anti CADM-140 antibody developing severe muscle symptoms, pharyngalgia and aleveolar hemorrhage in autopsy findings.
authors.affiliation: Department of Neurology, Nagoya Ekisaikai Hospital.
authors.forename: Kenta
authors.initials: K
authors.lastname: Sato
authors.forename: Saori
authors.initials: S
authors.lastname: Morozumi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Jun
authors.initials: J
authors.lastname: Ochiai
authors.forename: Chiyuki
authors.initials: C
authors.lastname: Mabuchi
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001344:Autopsy; D015415:Biomarkers / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D010455:Peptides / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000473:pathology; D020551:Pulse Therapy, Drug; D012720:Severity of Illness Index
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; C501597:CADM-140 peptide, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D003520:Cyclophosphamide; D008775:Methylprednisolone