title: Antiosteoporotic effect of orally administered yolk-derived peptides on bone mass in women.
abstract: The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6-month, randomized, double-blind clinical trial. Bone formation and resorption markers were measured at 0, 3, and 6 months, while bone mineral density (BMD) in the lumbar spines was measured at 0 and 6 months. Although the bone formation marker levels showed the similarity changes among the groups, bone resorption markers in the test HYP group were significantly decreased after 3 and 6 months in comparison to other groups (P < 0.05). After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups. Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.
authors.affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.
authors.forename: Adham M
authors.initials: AM
authors.lastname: Abdou
authors.affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Watabe
authors.affiliation: Matsushita Memorial Hospital Moriguchi City, Osaka, 570-8540, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yamane
authors.affiliation: Wada Calcium Pharmaceutical Co., Ltd. Osaka, 538-0043, Japan.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Isono
authors.affiliation: Wada Calcium Pharmaceutical Co., Ltd. Osaka, 538-0043, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okamura
authors.affiliation: Iwaki & Co., Ltd. Tokyo, 103-8403, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawahito
authors.affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Takeshima
authors.affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Masuda
authors.affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.
authors.forename: Mujo
authors.initials: M
authors.lastname: Kim
keywords: Antiosteoporotic; bone density; bone markers; osteoporosis; women; yolk-derived peptides