title: Japan Clinical Oncology Group (JCOG) prognostic index and characterization of long-term survivors of aggressive adult T-cell leukaemia-lymphoma (JCOG0902A).
abstract: This study evaluated the clinical features of 276 patients with aggressive adult T-cell leukaemia-lymphoma (ATL) in 3 Japan Clinical Oncology Group (JCOG) trials. We assessed the long-term survivors who survived >5 years and constructed a prognostic index (PI), named the JCOG-PI, based on covariates obtained by Cox regression analysis. The median survival time (MST) of the entire cohort was 11 months. In 37 patients who survived >5 years, no disease-related deaths in 10 patients with lymphoma-type were observed in contrast to the 10 ATL-related deaths in other types. In multivariate analysis of 193 patients, the JCOG-PI based on corrected calcium levels and performance status identified moderate and high risk groups with an MST of 14 and 8 months respectively (hazard ratio, 1·926). The JCOG-PI was reproducible in an external validation. Patients with lymphoma-type who survived >5 years might have been cured. The JCOG-PI is valuable for identifying patients with extremely poor prognosis and will be useful for the design of future trials combining new drugs or investigational treatment strategies.
authors.affiliation: Laboratory of Haematoimmunology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara-cho, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukushima
authors.forename: Shogo
authors.initials: S
authors.lastname: Nomura
authors.forename: Masanori
authors.initials: M
authors.lastname: Shimoyama
authors.forename: Taro
authors.initials: T
authors.lastname: Shibata
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Imaizumi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Moriuchi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Tomoyose
authors.forename: Kimiharu
authors.initials: K
authors.lastname: Uozumi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Fukushima
authors.forename: Atae
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Tara
authors.forename: Kisato
authors.initials: K
authors.lastname: Nosaka
authors.forename: Michihiro
authors.initials: M
authors.lastname: Hidaka
authors.forename: Naokuni
authors.initials: N
authors.lastname: Uike
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yoshida
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tamura
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishitsuka
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakata
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukuda
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Hotta
authors.forename: Kensei
authors.initials: K
authors.lastname: Tobinai
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017741:Survivors; D055815:Young Adult
keywords: Japan Clinical Oncology Group trials; adult T-cell leukaemia-lymphoma; long-term survivors; prognostic index