title: [24-hour combined pH-impedance measurement in differential diagnosis of non-erosive reflux disease and functional gastroesophageal disorders].
abstract: OBJECTIVE
  To study potentials of 24-hour combined pH-impedance measurement in differential diagnosis of nonerosive reflux disease and functional gastroesophageal disorders.
  
  
  METHODS
  Overall 60 patients with heartburn, belch and epigastric discomfort were investigated. All patients underwent esophagogastroduodenoscopy (EGDS), X-ray examination of upper gastrointestinal tract, 13C-urea breath test, 24-hour combined pH-impedance measurement.
  
  
  RESULTS
  Esophagitis grade 2-4 was diagnosed in 11 (18.3%) of 60 cases. In 49 (81.7%) no pathological changes were identify at EGDS and X-ray examination of upper gastrointestinal tract. Of them in 20 (33.3%) cases nonerosive reflux disease was revealed using 24-hour combined pH-impedance measurement. In 29 (48.3%) cases with the same clinical symptoms pH-impedance measurement data did not differ from normal, suggesting this group as group of patients with functional gastroesophageal disorders.
  
  
  CONCLUSIONS
  24-hour combined pH-impedance measurement is the most exact method which allows to identify gastroesophageal reflux episodes. On this basis in some cases it is possible to differentiate nonerosive reflux disease and functional gastroesophageal disorders. Application of pH-impedance measurement allows to recommend its introduction in wide clinical practice.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Morozova
authors.forename: A P
authors.initials: AP
authors.lastname: Pogromov
authors.forename: M G
authors.initials: MG
authors.lastname: Mnatsakanian
mesh_terms: D001944:Breath Tests; D003937:Diagnosis, Differential; D017097:Electric Impedance; D016145:Endoscopy, Digestive System; D050782:Esophageal pH Monitoring; D004947:Esophagus / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013270:Stomach / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology