title: Experimental treatment of Curvularia infection.
abstract: We have evaluated the efficacy of amphotericin B, posaconazole, and voriconazole in immunosuppressed murine models of disseminated infection by Curvularia spicifera and Curvularia hawaiiensis. The 3 antifungals improved survival of mice in comparison to controls; however, only the 2 azoles were able to reduce significantly the fungal load.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Katihuska
authors.initials: K
authors.lastname: Paredes
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.affiliation: Unitat d' Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain. Electronic address: josep.guarro@urv.cat.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001203:Ascomycota; D004195:Disease Models, Animal; D016867:Immunocompromised Host; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology; D065819:Voriconazole / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D065819:Voriconazole
keywords: Animal model; Bipolaris hawaiiensis; Bipolaris spicifera; Curvularia; Fungal infection