title: Polycyclic aromatic hydrocarbon distribution in serum of Saudi children using HPLC-FLD: marker elevations in children with asthma.
abstract: Diesel exhaust consists of a complex mixture of chemicals which contain known genotoxicants, one of which is polycyclic aromatic hydrocarbons (PAHs) which may be associated with adverse respiratory health outcomes. This study aimed to evaluate the distribution patterns of PAHs (anthracene, naphthalene, fluorene, phenanthrene, cyclopentaphenanthrene, pyrene, fluoranthene, benzanthracene, chrysene, benzo(e)pyrene, benzoacephenanthrylene, and benzo(a)pyrene) in serum collected from asthmatic and healthy control children. PAH serum levels were measured in samples collected from children who lived in 11 different locations in/round Riyadh, Saudi Arabia (Al-yarmouk, Usaibi, Sultana Al-kadema, Omrrojam, Kof, Janoob Dawdmi, Guberah, Arabbuah, Al-mozahemyah, Iskan Al-mazzer, and Al-gharabi) during the period 2010-2011. Our results showed that the highest total mean concentrations of PAH were found in serum samples collected from people who lived in Sultana Aljadhida, Almozahemyah, Guberah, and Omrrojam and were 663.9, 486.17, 412.18, and 258.6 ng ml(-1), respectively. The most prevalent PAHs in serum samples were naphthalene, bezanthracene, benzoacephenanthrylene, phenanthrene, chrysene, and benzo(a)pyrene with a frequency that ranged from 54.5 to 90.9 % positive samples. A close monitoring of PAH pollution is strongly recommended, especially in food and plant samples, because of their high bioaccumulation capacity.
authors.affiliation: Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia, ndaghri@ksu.edu.sa.
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Al-Daghri
authors.forename: Majed S
authors.initials: MS
authors.lastname: Alokail
authors.forename: Sherif H
authors.initials: SH
authors.lastname: Abd-Alrahman
authors.forename: Hossam M
authors.initials: HM
authors.lastname: Draz
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005453:Fluorescence; D006801:Humans; D011084:Polycyclic Aromatic Hydrocarbons / Q000097:blood*; D012529:Saudi Arabia
chemical_list: D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons