title: Fluvoxamine for the treatment of depression and parkinsonism in progressive supranuclear palsy.
abstract: Progressive supranuclear palsy (PSP) is a parkinsonian-like disorder characterized by postural instability, rigidity, bradykinesia, supranuclear ocular palsy, dysarthria, dysphagia and dementia. There is no satisfactory treatment. A 68-year-old woman with initial progressive supranuclear palsy is described, who was generally apathetic, withdrawn, lacked spontaneity in speech and behavior, and suffered episodes of depression. Treatment with levodopa/carbidopa was ineffective in controlling her parkinsonism and depression, but these symptoms responded to fluvoxamine. This response may be related to fluvoxamine's putative effect on the serotonin system.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyaoka
authors.forename: Haruo
authors.initials: H
authors.lastname: Seno
authors.forename: Takuji
authors.initials: T
authors.lastname: Inagaki
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
keywords: Depression; Fluvoxamine; Palsy; Parkinsonism; Progressive; Supranuclear