title: [The character of the morphological changes of the mucous membrane of the large intestine and the genetic polymorphism of IL-1RA, IL-1B, IL-4 TNFA in patient with irritable bowel syndrome].
abstract: The aim of this study was to evaluate the presence or absence of a relationship between the variants of the course of IBS and their association with genetic polymorphisms of genes and intergenic interaction of cytokines.
  
  
  METHODS
  The sample consisted of 81 patients, the diagnosis was verified according to the criteria of the Rome III, were isolated psychopathological, morphological complications, extra-intestinal symptoms. Polymorphism genotyping IL-1Ra, IL-b, IL-4, TNFa performed by PCR. Statistical treatment are a non-parametric analysis of multiple comparisons, hierarchical log-linear analysis. It is found out the relation between the clinical variants with morphological changes of the mucous membrane of the large intestine, the association between gender characteristics of patients with IBS is established and with genetic polymorphisms of cytokines.
authors.forename: A S
authors.initials: AS
authors.lastname: Sarsenbaeva
authors.forename: E L
authors.initials: EL
authors.lastname: Ivanova
authors.forename: A L
authors.initials: AL
authors.lastname: Burmistrova
authors.forename: I V
authors.initials: IV
authors.lastname: Drozdov
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D007413:Intestinal Mucosa / Q000473:pathology*; D007420:Intestine, Large / Q000473:pathology*; D043183:Irritable Bowel Syndrome / Q000235:genetics / Q000473:pathology; D008297:Male; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C508585:IL1B protein, human; C507763:IL1RN protein, human; C508598:IL4 protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4