title: Free-B-Ring flavonoids as potential lead compounds for colon cancer therapy.
abstract: Although flavonoids have been identified as a versatile source of anticancer agents, to the best of our knowledge, no study has yet investigated their anticolon cancer activity in depth. Therefore, the aim of this study was to investigate the association between the structural characteristics of flavonoids and their anticolon cancer activity in the Caco-2 human colon cancer cell line. Our findings demonstrated that the hydroxylation of C5 and C7 in ring A significantly enhanced the anticolon cancer activity of flavonoids over that of 5-fluorouracil, the classic reference cytotoxic agent. By contrast, the glycosylation or the presence of hydroxyl groups in ring B significantly decreased flavonoid anticancer activity. Collectively, these findings suggest a novel, rational design of flavonoid-related compounds that may improve the treatment of colorectal cancer.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ibrahim
authors.affiliation: Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sobeh
authors.affiliation: Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Aya
authors.initials: A
authors.lastname: Ismail
authors.affiliation: Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Alaa
authors.affiliation: Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Hussein
authors.initials: H
authors.lastname: Sheashaa
authors.affiliation: Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sobh
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Farid
authors.initials: F
authors.lastname: Badria
keywords: colorectal cancer; flavonoids; free-B-Ring flavonoids