title: Travelers with sickle cell disease.
abstract: BACKGROUND
  Sickle cell disease (SCD) is the most common genetic disease among persons with African ancestry. This article provides a background to SCD and reviews many important aspects of travel preparation in this population.
  
  
  METHODS
  The medical literature was searched for studies on travel-associated preparedness and complications in individuals with SCD. Topics researched included malaria, bacterial infections, vaccinations, dehydration, altitude, air travel, and travel preparedness.
  
  
  RESULTS
  There is very little published literature that specifically addresses the risks faced by travelers with SCD. Rates of medical complications during travel appear to be high. There is a body of literature that describes complications of SCD in indigenous populations, particularly within Africa. The generalizability of these data to a traveler is uncertain. Combining these sources of data and the broader medical literature, we address major travel-related questions that may face a provider preparing an individual with SCD for safe travel.
  
  
  CONCLUSIONS
  Travelers with SCD face considerable medical risks when traveling to developing tropical countries, including malaria, bacterial infections, hypovolemia, and sickle cell-associated vaso-occlusive crises. For individuals with SCD, frank counseling about the risks, vigilant preventative measures, and contingency planning for illness while abroad are necessary aspects of the pre-travel visit.
authors.affiliation: Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
authors.forename: Shaina M
authors.initials: SM
authors.lastname: Willen
authors.forename: Courtney D
authors.initials: CD
authors.lastname: Thornburg
authors.forename: Paul M
authors.initials: PM
authors.lastname: Lantos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D003967:Diarrhea / Q000517:prevention & control; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010358:Patient Participation; D014195:Travel; D057236:Travel Medicine; D014611:Vaccination / Q000706:statistics & numerical data*