title: Sarcolipin provides a novel muscle-based mechanism for adaptive thermogenesis.
abstract: The sarco(endo)plasmic reticulum Ca-ATPase (SERCA) transports Ca into the sarcoplasmic reticulum lumen and contributes significantly to skeletal muscle metabolic rate. Sarcolipin (SLN) has been shown recently to uncouple Ca transport from adenosine triphosphate hydrolysis by SERCA. We have hypothesized that SLN provides a novel mechanism of adaptive thermogenesis within skeletal muscle and protects against diet-induced obesity.
authors.affiliation: Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gamu
authors.forename: Eric
authors.initials: E
authors.lastname: Bombardier
authors.forename: Ian C
authors.initials: IC
authors.lastname: Smith
authors.forename: Val A
authors.initials: VA
authors.lastname: Fajardo
authors.forename: A Russell
authors.initials: AR
authors.lastname: Tupling
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001481:Basal Metabolism; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism*; D011510:Proteolipids / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism*; D022722:Thermogenesis; D000071256:Uncoupling Protein 1
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D009124:Muscle Proteins; D011510:Proteolipids; D000071256:Uncoupling Protein 1; C077258:sarcolipin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium