title: [Ulipristal acetate (Esmya): a selective modulator of progesterone receptors, new treatment of uterine fibromatosis].
abstract: Uterine fibromatosis is a frequent benign gynaecological disease causing heavy menstrual bleeding and in some cases anaemia. Until now, medical treatment aimed to obtain amenorrhea by administration of progestins or Gn-RH agonists. By inducing hypo-oestrogenism, a reduction of myoma size is observed with Gn-RH agonists but after cessation of the treatment, initial myoma size is noted. The impact of progesterone in myoma growth is nowadays demonstrated and use of selective modulators of progesterone receptors represents a new medical approach of this disease.
authors.forename: M
authors.initials: M
authors.lastname: Nisolle
authors.forename: F
authors.initials: F
authors.lastname: Closon
authors.forename: A
authors.initials: A
authors.lastname: Firquet
authors.forename: M
authors.initials: M
authors.lastname: Top
authors.forename: A
authors.initials: A
authors.lastname: Pintiaux
mesh_terms: D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000473:pathology; D009649:Norpregnadienes / Q000494:pharmacology / Q000627:therapeutic use*; D011374:Progesterone / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D009649:Norpregnadienes; D011980:Receptors, Progesterone; D011374:Progesterone; C555622:ulipristal acetate