title: Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in east China.
abstract: OBJECTIVE
  To validate the REM Sleep Behavior Disorder (RBD) Questionnaire-Hong Kong (RBDQ-HK) in polysomnography (PSG)-confirmed RBD and non-RBD subjects, and to evaluate its usefulness in different clinical populations.
  
  
  METHODS
  In total, 325 subjects (115 RBD and 210 controls) from East China were enrolled. After patients had finished the structured interview, and completed the RBDQ-HK and video-PSG test, we evaluated the reliability of RBDQ-HK (areas under the curves (AUC), the best cut-off values, factor 2 of RBDQ-HK, and overall scale) and validated the usefulness of RBDQ-HK between the Parkinson disease (PD) and obstructive sleep apnea (OSA) groups.
  
  
  RESULTS
  The best cut-off values for factor 2 of RBDQ-HK were located at 7/8 with a sensitivity of 90% and specificity of 82% (AUC=0.911), and for RBDQ-HK overall scale were located at 17 with a sensitivity of 85% and specificity of 81% (AUC=0.892) in all subjects. Both factor 2 and overall scale of RBDQ-HK are valid in all subjects (PD and OSA patients), with a higher accuracy given by factor 2 of RBDQ-HK.
  
  
  CONCLUSIONS
  RBDQ-HK and its factor 2 are useful and validated RBD screening instruments, and could be used as a tool for screening RBD in patients with PD and OSA.
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China; Sleep Center, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Si-Si
authors.initials: SS
authors.lastname: Shen
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China; Sleep Center, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Kang-Ping
authors.initials: KP
authors.lastname: Xiong
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Cheng-Jie
authors.initials: CJ
authors.lastname: Mao
authors.affiliation: Sleep Center, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Huang
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China; Sleep Center, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Sleep Center, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China; Sleep Center, Second Affiliated Hospital of Soochow University, Suzhou, China; Institutes of Neuroscience, Soochow University, Suzhou, China. Electronic address: liucf@suda.edu.cn.
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Liu
mesh_terms: D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000523:psychology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires
keywords: Obstructive sleep apnea syndrome; Parkinson disease; REM Sleep Behavior Disorder Questionnaire – Hong Kong (RBDQ-HK); REM sleep behavior disorder; Reliability; Validity