title: Association of Connexin37 C1019T with myocardial infarction and coronary artery disease: a meta-analysis.
abstract: BACKGROUND
  Several studies have reported that Connexin37 (Cx37) gene C1019T polymorphism is associated with myocardial infarction (MI) and coronary artery disease (CAD). However, the results remain contradictory.
  
  
  RESULTS
  Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. A total of 3498 MI cases and 3986 controls, as well as 1808 CAD cases and 1197 controls were enrolled in this meta-analysis. For MI, the overall ORs and 95% CIs of 1019T were 1.04, 0.95-1.15; and 1.02, 0.85-1.22 in dominant and recessive models, respectively. For CAD, the overall ORs and 95% CIs of 1019T were 0.61, 0.51-0.72; and 0.52, 0.43-0.62 in dominant and recessive models, respectively. No publication bias was found in this meta-analysis.
  
  
  CONCLUSIONS
  This meta-analysis showed that Cx37 C1019T was a risk factor for MI and a protective factor for CAD.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wen
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Jian-Zeng
authors.initials: JZ
authors.lastname: Dong
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China. Electronic address: chshma@vip.sina.com.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017630:Connexins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D065840:Protective Factors; D018570:Risk Assessment; D012307:Risk Factors; D000097006:Gap Junction alpha-4 Protein
chemical_list: D017630:Connexins; D000097006:Gap Junction alpha-4 Protein
keywords: Connexin37; Coronary artery disease; Meta-analysis; Myocardial infarction; Polymorphism