title: Analysis of computed tomography features of fungal sinusitis and their correlation with nasal endoscopy and histopathology findings.
abstract: OBJECTIVE
  The purpose of this study was to analyze the computed tomography (CT) features of fungal sinusitis and to correlate them with nasal endoscopy and histopathological findings.
  
  
  METHODS
  Our study included 16 patients of either sex and any age group who presented in the otorhinolaryngology clinic at our hospital and had evidence of definite sinonasal disease on clinical evaluation. Multidetector CT was carried out on Somatom definition AS + 128 slice CT Machine by Siemens Germany Ltd. Axial sections were performed with the plane of data acquisition parallel to the hard palate and slice thickness of 3 mm, reconstructions at 0.75 mm in coronal and sagittal planes. Scanning parameters included 190 mA S, 120 KV and tube rotation time of 0.5 s. Provisional CT diagnosis was made in all cases and correlated with nasal endoscopy and histopathological findings.
  
  
  RESULTS
  Out of total 16 patients, 12 showed immunocompromised status and had infection with mucormycosis. Out of 12, 9 patients (75%) showed extension of disease beyond the sinonasal cavities and 4 (33.3%) showed evidence of bone destruction. All patients with candidiasis showed soft-tissue attenuation with hyperdense areas on CT scan. Nearly, 66.6% patients with aspergillosis showed soft-tissue attenuation with hyperdense areas and expansion of sinonasal cavities. Fifteen patients (93%) were proved to be of fungal sinusitis on histopathology. One patient of non-specific granulomatous infection showed bone destruction and mimicked fungal sinusitis on CT.
  
  
  CONCLUSIONS
  In the present study, fungal sinusitis could be correctly diagnosed on CT with high accuracy. Thus, understanding the different CT findings of fungal sinusitis allows the radiologist to play a crucial role in the diagnosis and prompt treatment.
authors.affiliation: Department of Radiodiagnosis, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors.forename: Kamini
authors.initials: K
authors.lastname: Gupta
authors.forename: Kavita
authors.initials: K
authors.lastname: Saggar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy; D010254:Paranasal Sinus Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012852:Sinusitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D000935:Antifungal Agents