title: [Trend pattern of the incidence of thyroid cancer in Murcia Region (Spain) from 1984 to 2008].
abstract: OBJECTIVE
  To study the trend pattern of the incidence of thyroid cancer.
  
  
  METHODS
  We selected incident cases of thyroid cancer occurring in the Region of Murcia (Spain) in 1984-2008. The variables gathered were age, sex, date of diagnosis, and morphology. We calculated incidence rates and the annual percentage of change using Bayesian age-period-cohort models.
  
  
  RESULTS
  During the study period, 1414 cases were diagnosed, representing an increase in adjusted rates from 2.9/100000 in 1984-1988 to 7.3 in 2004-2008. The incidence was 3.5 times higher in women than in men and the most frequent morphology was papillary carcinoma (67.7%). An increasing trend was found in both genders; these increments were more pronounced in papillary carcinoma. In women, the incidence increased with age, calendar year, and in those born in 1945-1963. The incidence of papillary microcarcinoma increased four-fold in women.
  
  
  CONCLUSIONS
  Thyroid cancer used to be a rare cancer but has become an emerging tumor. The greatest changes were found in papillary thyroid cancer, including a gradual increase in the proportion of microcarcinoma.
authors.affiliation: Servicio de Epidemiología, Consejería de Sanidad y Política Social, Murcia, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España. Electronic address: mdolores.chirlaque@carm.es.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.affiliation: Servicio de Epidemiología, Consejería de Sanidad y Política Social, Murcia, España; Unidad Docente de Medicina Preventiva y Salud Pública, Murcia, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Moldenhauer
authors.affiliation: Servicio de Epidemiología, Consejería de Sanidad y Política Social, Murcia, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España; Departamento de Ciencias Socio-Sanitarias, Universidad de Murcia, Murcia, España.
authors.forename: Diego
authors.initials: D
authors.lastname: Salmerón
authors.affiliation: Servicio de Epidemiología, Consejería de Sanidad y Política Social, Murcia, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España; Departamento de Ciencias Socio-Sanitarias, Universidad de Murcia, Murcia, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D013997:Time Factors; D055815:Young Adult
keywords: Cohort effect; Cáncer de tiroides; Efecto cohorte; Histology; Histología; Incidence; Incidencia; Tendencias; Thyroid neoplasm; Trends