title: Relationship betweenp53gene codon-72 polymorphisms and hypertrophic scar formation following caesarean section.
abstract: The aim of the present study was to determine the relationship betweenp53gene codon-72 polymorphisms and hypertrophic scar formation following caesarean section (CS). Blood samples from 260 female patients were collected one week following a CS for the detection ofp53gene polymorphisms using a molecular beacon-coupled quantitative polymerase chain reaction technique. Patients had follow-ups for 12-18 months to observe the scar formation. From these observations, the relationship between thep53codon-72 polymorphisms and hypertrophic scar formation occurrence was investigated. Among the patients with the CCC/CCC genotype, nine patients had hypertrophic scars and 46 patients showed normal healing, which is a ratio of 0.19. However, the follow-up investigations indicated that the presence of a homozygous or heterozygous C-to-G alteration at the codon-72 site in genep53resulted in 13 patients with hypertrophic scars and 192 patients with normal healing, which is a ratio of 0.07. Therefore, these results indicate that patients with the CCC/CCC genotype had a higher risk of developing hypertrophic scars compared with that for patients with the CCC/CGC or CGC/CGC genotypes.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China ; Department of Breast Surgery, Guandong Traditional Chinese Medicine Hospital, Guangzhou, Guangdong 510000, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China ; Department of Plastic Surgery, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, P.R. China.
authors.forename: Nong
authors.initials: N
authors.lastname: Liao
authors.affiliation: Department of Plastic Surgery, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Cell Biology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Weisen
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, P.R. China.
authors.forename: Yingtao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, P.R. China.
authors.forename: Shaojing
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
keywords: hypertrophic scar; molecular beacon quantitative polymerase chain reaction; p53 gene codon-72