title: Dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial.
abstract: BACKGROUND
  We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people.
  
  
  METHODS
  A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale.
  
  
  RESULTS
  The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation.
  
  
  CONCLUSIONS
  SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue.
  
  
  BACKGROUND
  trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922.
authors.affiliation: Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, France. jc.rech@bionov.fr.
authors.forename: Julie
authors.initials: J
authors.lastname: Carillon
authors.affiliation: Seppic Company, 22 Terasse Bellini, Puteaux 92806, France. claire.notin@airliquide.com.
authors.forename: Claire
authors.initials: C
authors.lastname: Notin
authors.affiliation: Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, France. karine.schmitt@bionov.fr.
authors.forename: Karine
authors.initials: K
authors.lastname: Schmitt
authors.affiliation: Therapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, 2 rue Ambroise-Paré, Paris 75010, France. guy.simoneau@lrb.aphp.fr.
authors.forename: Guy
authors.initials: G
authors.lastname: Simoneau
authors.affiliation: Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, France. dominique.lacan@bionov.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Lacan
mesh_terms: D000328:Adult; D019662:Cucurbitaceae; D019587:Dietary Supplements; D004311:Double-Blind Method; D005221:Fatigue / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D005222:Mental Fatigue / Q000188:drug therapy*; D008875:Middle Aged; D013312:Stress, Physiological / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000494:pharmacology*
chemical_list: D013482:Superoxide Dismutase