title: New laboratory markers for the management of rheumatoid arthritis patients.
abstract: Rheumatoid arthritis, the most prominent of systemic autoimmune rheumatic diseases, represents an important social health problem. Recent insights into the immunopathogenic mechanism of this complex and multiform illness might open new perspectives for a more appropriate laboratory approach. In this review we focus on the most relevant pathogenetic mechanism; indicating the laboratory biomarkers specifically linked to early diagnosis, prognosis, evolutive aspects of the disease, and therapeutic efficacy. Evidence based on laboratory medicine could provide the best outcome for patients.
authors.forename: Daniela P
authors.initials: DP
authors.lastname: Foti
authors.forename: Marta
authors.initials: M
authors.lastname: Greco
authors.forename: Eleonora
authors.initials: E
authors.lastname: Palella
authors.forename: Elio
authors.initials: E
authors.lastname: Gulletta
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D059811:HLA-DRB1 Chains / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D059811:HLA-DRB1 Chains; D018121:Receptors, Cytokine; D014157:Transcription Factors; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22