title: XRCC1 rs25487 polymorphism predicts the survival of patients after postoperative radiotherapy and adjuvant chemotherapy for breast cancer.
abstract: BACKGROUND
  Single nucleotide polymorphisms (SNPs) in a DNA-repair gene, X-Ray repair cross complementing group 1 (XRCC1), have been associated with the survival of patients with breast cancer. We investigated the predictive value of XRCC1 SNP (rs25487) in patients with early breast cancer.
  
  
  METHODS
  The XRCC1 rs25487 genotypes of 411 Finnish patients with breast cancer were analyzed by a polymerase chain reaction-restriction fragment length polymorphism-based method. Survival was assessed by Kaplan-Meier method and Cox regression analysis according to the XRCC1 genotypes in specified adjuvant treatment groups.
  
  
  RESULTS
  The rs25487 variant AA genotype was associated with worse breast cancer-specific and overall survival in 238 patients receiving postoperative radiotherapy (p=0.031 and p=0.030, respectively). The AA genotype predicted worse breast cancer-specific survival among 75 patients treated with adjuvant chemotherapy (p=0.047).
  
  
  CONCLUSIONS
  The XRCC1 rs25487 genotype may predict the outcome of postoperative radiotherapy and adjuvant chemotherapy in breast cancer.
authors.affiliation: Cancer Center, Kuopio University Hospital, Kuopio, Finland Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland maria.tengstrom@kuh.fi.
authors.forename: Maria
authors.initials: M
authors.lastname: Tengström
authors.affiliation: Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland Imaging Center, Pathology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Arto
authors.initials: A
authors.lastname: Mannermaa
authors.affiliation: Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland Imaging Center, Pathology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Kosma
authors.affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.
authors.forename: Ari
authors.initials: A
authors.lastname: Hirvonen
authors.affiliation: Cancer Center, Kuopio University Hospital, Kuopio, Finland Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
authors.forename: Vesa
authors.initials: V
authors.lastname: Kataja
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D018275:Carcinoma, Lobular / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D015996:Survival Rate; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human
keywords: XRCC1; breast cancer; chemotherapy; polymorphism; radiotherapy