title: Chloranthones A - D: minor and unprecedented dinor-eudesmenes from Chloranthus elatior.
abstract: Four novel naturally occurring diastereoisomers of dinor-eudesmenes, named chloranthones A-D (1-4, resp.), were isolated as minor components from the EtOH extract of the aerial parts of Chloranthus elatior. The unprecedented framework was established using extensive 2D-NMR techniques. Their absolute configurations were deduced from the observed Cotton effects in their circular dichroism (CD) spectra. A plausible biosynthetic pathway to the dinor-eudesmenes is proposed.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Rd., Shanghai 201203, P. R. China, (phone/fax: +86-21-51980172); Department of Natural Products for Chemical Genetic Research, Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, No. 3663 North Zhongshan Rd., Shanghai 200062, P. R. China.
authors.forename: Shu-Ting
authors.initials: ST
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.forename: Wen-Xuan
authors.initials: WX
authors.lastname: Wang
authors.forename: Van-Binh
authors.initials: VB
authors.lastname: Bui
authors.forename: Guang-Lei
authors.initials: GL
authors.lastname: Ma
authors.forename: Ya
authors.initials: Y
authors.lastname: Huang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Guo-Xun
authors.initials: GX
authors.lastname: Yang
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification*; D002460:Cell Line; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D012717:Sesquiterpenes
keywords: Chloranthones; Chloranthus elatior; Diastereoisomers; Dinor-eudesmenes; Eudesmane sesquiterpenes