title: A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes(‡).
abstract: The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub-gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI, and were Olig2-positive and glial fibrillary acid protein-negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC, a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Bentley
authors.affiliation: Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
authors.forename: G N
authors.initials: GN
authors.lastname: Burcham
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
authors.forename: H G
authors.initials: HG
authors.lastname: Heng
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Levine
authors.affiliation: Gulf Coast Veterinary Neurology and Neurosurgery, Houston, TX, USA.
authors.forename: R
authors.initials: R
authors.lastname: Longshore
authors.affiliation: VCA West Los Angeles Animal Hospital, Los Angeles, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Carrera-Justiz
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Cameron
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kopf
authors.affiliation: Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D004285:Dogs; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D018302:Neoplasms, Neuroepithelial / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins
keywords: MRI; brain; canine; glioma; tumour