title: Extracellular matrix modulates angiogenesis in physiological and pathological conditions.
abstract: Angiogenesis is a multistep process driven by a wide range of positive and negative regulatory factors. Extracellular matrix (ECM) plays a crucial role in the regulation of this process. The degradation of ECM, occurring in response to an angiogenic stimulus, leads to degradation or partial modification of matrix molecules, release of soluble factors, and exposure of cryptic sites with pro- and/or antiangiogenic activity. ECM molecules and fragments, resulting from proteolysis, can also act directly as inflammatory stimuli, and this can explain the exacerbated angiogenesis that drives and maintains several inflammatory diseases. In this review we have summarized some of the more recent literature data concerning the molecular control of ECM in angiogenesis in both physiological and pathological conditions.
authors.affiliation: Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Ospedale "Col. D'Avanzo", 71121 Foggia, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Neve
authors.affiliation: Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Ospedale "Col. D'Avanzo", 71121 Foggia, Italy.
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Cantatore
authors.affiliation: Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Ospedale "Col. D'Avanzo", 71121 Foggia, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Maruotti
authors.affiliation: Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Ospedale "Col. D'Avanzo", 71121 Foggia, Italy.
authors.forename: Addolorata
authors.initials: A
authors.lastname: Corrado
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy ; National Cancer Institute "Giovanni Paolo", 70124 Bari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D005109:Extracellular Matrix / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics*; D018919:Neovascularization, Physiologic / Q000235:genetics*; D059748:Proteolysis