title: Acute antidepressant response to fluoxetine and sertraline in psychiatric outpatients with psychomotor agitation.
abstract: BACKGROUND
  Sertraline and fluoxetine have different pharmacologic and pharmacokinetic profiles, which may be of clinical relevance in the determination of treatment response in different subtypes of depression.
  
  
  OBJECTIVE
  To analyse the efficacy of sertraline and fluoxetine in a subgroup of 78 patients with evidence of significant psychomotor agitation (HAM-D item 8 &#104 1 and HAM-D item 9 &#83 2 at study entry) in a 6-week study comparing sertraline (50 - 100 mg/day) and fluoxetine (20 - 40 mg/day) for the treatment of major depression in 286 psychiatric outpatients.
  
  
  RESULTS
  The proportion of patients with psychomotor agitation responding ( &#83 50% reduction HAM-D score) at last visit was significantly ( P < 0.05) higher in the sertraline group than in the fluoxetine group (62% vs 39%, respectively). Most of the secondary efficacy parameters showed significantly ( P &#104 0.05) greater improvement in the sertraline treatment group at last visit: HAM-D &#104 8, HAM-D total score, HAM-D anxiety/somatization factor, HAM-D weight factor, HAM-A total score, CGI-S, Raskin Depression score, and Covi Anxiety score.
  
  
  CONCLUSIONS
  The findings of this retrospective data analysis suggest that fluoxetine may be a less efficacious antidepressant than sertraline in patients with psychomotor agitation.
authors.forename: M F
authors.initials: MF
authors.lastname: Lane
keywords: Depression Fluoxetine Sertraline Psychomotor Agitation