title: Metabolic bone disease of prematurity: report of four cases.
abstract: Osteopenia of prematurity has become a common problem recently because of improved survival rates of infants with very low birth weight (VLBW). The incidence of neonatal osteopenia is inversely correlated with gestational age and birth weight. Herein, we present four cases of preterm osteopenia that were referred to the pediatric endocrinology outpatient clinic with diverse clinical and laboratory findings and we discuss the clinical course of these infants with regard to bone disease after discharge from the neonatal intensive care unit (NICU). This report highlights the importance of enteral calcium, phosphorus and vitamin D support at adequate doses following discharge from NICU for preterm infants with VLBW who are at risk of metabolic bone disease.
authors.affiliation: eynep Kamil Gynecologic and Pediatric Training and Research Hospital, Department of Pediatric Endocrinology, İstanbul, Turkey. E-ma-il: gulyesiltepe@gmail.com.
authors.forename: Gül
authors.initials: G
authors.lastname: Yeşiltepe Mutlu
authors.forename: Heves
authors.initials: H
authors.lastname: Kırmızıbekmez
authors.forename: Elif
authors.initials: E
authors.lastname: Ozsu
authors.forename: Ilkay
authors.initials: I
authors.lastname: Er
authors.forename: Sükrü
authors.initials: S
authors.lastname: Hatun
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000151:congenital*; D002136:Calcium, Dietary / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D008297:Male; D016226:Phosphorus, Dietary / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D002136:Calcium, Dietary; D016226:Phosphorus, Dietary; D014807:Vitamin D; D000469:Alkaline Phosphatase