title: Challenges and promises in modeling dermatologic disorders with bioengineered skin.
abstract: The tremendous cost of drug development is often attributed to the long time interval between identifying lead compounds in preclinical studies to assessing clinical efficacy in randomized clinical trials. Many candidate molecules show promise in cell culture or animal models, only to fail in late stage in human investigations. There is a need for novel technologies that allow investigators to quickly and reliably predict drug safety and efficacy. The advent of microtechnology has made it possible to integrate multiple microphysiologic organ systems into a single microfabricated chip. This review focuses on three-dimensional engineered skin, which has enjoyed a long history of uses both in clinical treatments of refractory ulcers and as a laboratory model. We discuss current biological and engineering challenges in construction of a robust bioengineered skin and provide a blueprint for its potential utility to model dermatologic disorders such as psoriasis or cutaneous drug reactions.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA Departments of Dermatology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
authors.forename: Narat J
authors.initials: NJ
authors.lastname: Eungdamrong
authors.affiliation: Departments of Dermatology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Higgins
authors.affiliation: Departments of Dermatology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
authors.forename: Zongyou
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
authors.forename: Wen-Han
authors.initials: WH
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Gillette
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Sia
authors.affiliation: Departments of Dermatology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA Department of Genetics & Development, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA amc65@columbia.edu.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Christiano
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods; D006801:Humans; D056656:Lab-On-A-Chip Devices; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods
keywords: Dermatology; bioengineering; microphysiologic systems; psoriasis; skin equivalents; tissue engineering