title: Rothia bacteremia: a 10-year experience at Mayo Clinic, Rochester, Minnesota.
abstract: Rothia spp. are Gram-positive cocco-bacilli that cause a wide range of serious infections, especially in immunocompromised hosts. Risk factors for Rothia mucilaginosa (previously known as Stomatococcus mucilaginosus) bacteremia include prolonged and profound neutropenia, malignancy, and an indwelling vascular foreign body. Here, we describe 67 adults at the Mayo Clinic in Rochester, MN, from 2002 to 2012 with blood cultures positive for Rothia. Twenty-five of these patients had multiple positive blood cultures, indicating true clinical infection. Among these, 88% (22/25) were neutropenic, and 76% (19/25) had leukemia. Common sources of bacteremia were presumed gut translocation, mucositis, and catheter-related infection. One patient died with Rothia infection. Neutropenic patients were less likely to have a single positive blood culture than were nonneutropenic patients. Antimicrobial susceptibility testing was performed on 21% of the isolates. All of the tested isolates were susceptible to vancomycin and most beta-lactams; however, four of six tested isolates were resistant to oxacillin. There was no difference between the neutropenic and nonneutropenic patients in need of intensive care unit care, mortality, or attributable mortality.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Poornima
authors.initials: P
authors.lastname: Ramanan
authors.affiliation: Department of Pharmacy, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Jason N
authors.initials: JN
authors.lastname: Barreto
authors.affiliation: Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Osmon
authors.affiliation: Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA tosh.pritish@mayo.edu.
authors.forename: Pritish K
authors.initials: PK
authors.lastname: Tosh
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D001769:Blood / Q000382:microbiology; D015331:Cohort Studies; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000150:complications; D008297:Male; D008826:Microbial Sensitivity Tests; D008835:Micrococcaceae / Q000302:isolation & purification*; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents