title: Palladium-catalyzed oxidative cyclization of tertiary enamines for synthesis of 1,3,4-trisubstituted pyrroles and 1,3-disubstituted indoles.
abstract: A novel and efficient palladium-catalyzed intramolecular oxidative cyclization of tertiary enamines for the synthesis of 1,3,4-trisubstituted pyrroles and 1,3-disubstituted indoles has been developed. Trifluoroacetic acid plays an important role in the reaction. A series of pyrroles and indoles with substitution patterns that are not easily accessible by traditional routes were synthesized in good yields under mild conditions.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University , Xi'an 710069, P. R. China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Lian
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Ren
authors.forename: Yao-Yu
authors.initials: YY
authors.lastname: Wang
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Guan
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D000588:Amines; D007211:Indoles; D011758:Pyrroles; D010165:Palladium; D014269:Trifluoroacetic Acid