title: [The changes of inflammatory cytokines and their clinical significance in patients of inferior ST-segment elevation acute myocardial infarction with anterior ST-segment depression].
abstract: OBJECTIVE
  To investigate the level of Hs-CRP, Fib,IL-6, TNF-α,MDA, SOD, and analyse the correlation between the level of plasma inflammatory cytokines and clinical significance in patients with anterior ST-segment depression.
  
  
  METHODS
  We choose 360 patients with inferior ST Segment elevation acute myocardial infarction from May 2007 to Sep 2012 in rescue Center of Anzhen Hospital, in Anzhen Hospital, and all the patients received percutaneous coronary intervention treatment and the vascular lesions besides culprit vessel were observed. All the patients were divided into two groups: control group (n = 180) and anterior ST-segment depression group (n = 180). 8ml venous blood was obtained from all the patients, and then plasma were separated. The level of plasma Hs-CRP, Fib, IL-6, TNF-α, MDA, SOD were investigated by Biochemistry and ELISA. And the relativity between the level of plasma inflammatory cytokines and anterior ST-segment depression in patients with inferior acute myocardial infarction was analysed.
  
  
  RESULTS
  The proportion of double vessel coronary disease, three coronary artery lesion is higher in anterior ST-segment depression group compared with control group (P < 0.01) . Compared with control group, the level of Hs-CRP, Fib, IL-6, TNF-α,MDA, SOD of anterior ST-segment depression group are inclined significantly (P < 0.01).
  
  
  CONCLUSIONS
  The level of plasma inflammatory cytokines and the degree of lipid peroxidation can reflect the severity of coronary artery disease and may have certain value in predicting the severity of disease.
authors.affiliation: Department of Emergency and Critical Care Center, Capital Medical University Affiliated Beijing Anzhen Hospital,Beijing 100029, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ye
authors.affiliation: Department of Emergency and Critical Care Center, Capital Medical University Affiliated Beijing Anzhen Hospital,Beijing 100029, China. Email: yyymmm999@sina.com.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D004562:Electrocardiography; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D056989:Inferior Wall Myocardial Infarction / Q000097:blood / Q000503:physiopathology; D015850:Interleukin-6 / Q000097:blood; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D013482:Superoxide Dismutase / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D005340:Fibrinogen; D002097:C-Reactive Protein; D013482:Superoxide Dismutase