title: Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.
abstract: A series of new heterometallic gold(I) thiolates containing ferrocenyl-phoshines were synthesized. Their antimicrobial properties were studied and compared to that of FDA-approved drug, auranofin (Ridaura), prescribed for the treatment of rheumatoid arthritis. MIC in the order of one digit micromolar were found for most of the compounds against Gram-positive bacteria Staphylococcus aureus and CA MRSA strains US300 and US400. Remarkably, auranofin inhibited S. aureus, US300 and US400 in the order of 150-300 nM. This is the first time that the potent inhibitory effect of auranofin on MRSA strains has been described. The effects of a selected heterometallic compound and auranofin were also studied in a non-tumorigenic human embryonic kidney cell line (HEK-293).
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA; Department of Biology, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA.
authors.forename: Yozane
authors.initials: Y
authors.lastname: Hokai
authors.affiliation: Department of Biology, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA.
authors.forename: Boruch
authors.initials: B
authors.lastname: Jurkowicz
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Fernández-Gallardo
authors.affiliation: Department of Biology, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA.
authors.forename: Nuruddinkodja
authors.initials: N
authors.lastname: Zakirkhodjaev
authors.affiliation: Departamento de Química Inorgánica, Universidad de Valencia, Burjassot, Valencia 46100, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Sanaú
authors.affiliation: Department of Biology, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA.
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Muth
authors.affiliation: Department of Chemistry, Brooklyn College and The Graduate Center, The City University of New York, Brooklyn, NY 11210, USA. Electronic address: mariacontel@brooklyn.cuny.edu.
authors.forename: María
authors.initials: M
authors.lastname: Contel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001310:Auranofin / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D057809:HEK293 Cells / Q000187:drug effects; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D050607:Organogold Compounds; D001310:Auranofin
keywords: Antimicrobial; Auranofin; Heterometallic gold–thiolates; MRSA