title: The constituents of Michelia compressa var. formosana and their bioactivities.
abstract: Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5±0.3 and 9.6±0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.
authors.affiliation: Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. yuyichan@mail.stust.edu.tw.
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Chan
authors.affiliation: Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan. paul@mail.cmu.edu.tw.
authors.forename: Shin-Hun
authors.initials: SH
authors.lastname: Juang
authors.affiliation: Department of Pharmacy, China Medical University, Taichung 40402, Taiwan. gjhuang@mail.cmu.edu.tw.
authors.forename: Guan-Jhong
authors.initials: GJ
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. truthloveroy@yahoo.com.tw.
authors.forename: Yu-Ren
authors.initials: YR
authors.lastname: Liao
authors.affiliation: Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan. yufons@gmail.com.
authors.forename: Yu-Fon
authors.initials: YF
authors.lastname: Chen
authors.affiliation: School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. ujin1205@gmail.com.
authors.forename: Chia-Che
authors.initials: CC
authors.lastname: Wu
authors.affiliation: School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. chtchang@ntu.edu.tw.
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Chang
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. tswu@mail.ncku.edu.tw.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019169:Jurkat Cells; D029562:Magnoliaceae / Q000737:chemistry* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001060:Aporphines; D010936:Plant Extracts; C000594741:cyathisterol; C000594740:soemerine; D009569:Nitric Oxide