title: Disseminated intravascular coagulation in acute promyelocytic leukaemia and its impact on the induction failure: a single centre study.
abstract: Life-threatening coagulopathy associated with acute promyelocytic leukemia (APL) has been the defining clinical characteristic and is an important risk factor for fatal haemorrhage and early death. Pathogenesis of coagulopathy in APL is complex and mainly includes disseminated intravascular coagulation (DIC). The study was done to see the status of DIC and its impact on the outcome of APL in our setting. Among the total 60 patients, induction mortality rate was 30% and remission rate was 70%. The main cause of induction mortality was bleeding that accounts for 66.7% of mortality. DIC was present among 32 out of 60 patients (53.33%). Induction mortality has significant relationship to DIC as the induction mortality rate is 47% in patients with DIC and 11% in patient without DIC (P value 0.0009). Induction motality rate in low, intermediate and high risk group is 6.70%, 24% and 58% respectively (p value < 0.0001). Finally, risk group subclassification revealed presence of DIC in high risk group has the highest early mortality rate.
authors.forename: F
authors.initials: F
authors.lastname: Rahman
authors.forename: A L
authors.initials: AL
authors.lastname: Kabir
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Aziz
authors.forename: M N
authors.initials: MN
authors.lastname: Baqui
authors.forename: T F
authors.initials: TF
authors.lastname: Dipta
authors.forename: A B M
authors.initials: AB
authors.lastname: Yunus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001459:Bangladesh / Q000453:epidemiology; D002423:Cause of Death; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012074:Remission Induction; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents