title: Hepatoprotective effect of Arctium lappa root extract on cadmium toxicity in adult Wistar rats.
abstract: This study was performed to determine the effects of Arctium lappa (Al) to protect against cadmium damage in the rat liver. Male rats received a single i.p. dose of CdCl2 (1.2 mg/kg body weight (BW)) with or without Al extract administered daily by gavage (300 mg/kg BW) for 7 or 56 days. After 7 days, Al caused plasma transaminase activity to diminish in groups Al (glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT)) and CdAl (GPT). After 56 days, GOT and GPT plasma activities were reduced in the Cd group. No alteration in plasma levels of creatinine, total bilirubin, and total protein were observed. GOT liver activity increased in the Cd group. No alteration was observed in superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), and malondialdehyde (MDA) dosage. In the Cd group, hepatocyte proportion decreased and sinusoid capillary proportion increased. In the Al and CdAl groups, the nuclear proportion increased and the cytoplasmic proportion decreased. The hepatocyte nucleus density reduced in Cd and increased in the Al group. After 56 days, there was no alteration in the Cd group. In Al and CdAl groups, the nuclear proportion increased without cytoplasmic proportion variation, but the sinusoid capillary proportion was reduced. The hepatocyte nucleus density decreased in the Cd group and increased in the Al and CdAl groups. In conclusion, the liver function indicators showed that A. lappa protected the liver against cadmium toxicity damage.
authors.affiliation: Departamento de Ciências Biológicas, Universidade Estadual do Paraná/Campus Paranaguá, Rua Comendador Correia Junior, 117-Centro, Paranaguá, Paraná, 83203-560, Brazil, fpredes@yahoo.com.br.
authors.forename: Fabricia
authors.initials: F
authors.lastname: de Souza Predes
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: da Silva Diamante
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Foglio
authors.forename: Camila de Andrade
authors.initials: Cde A
authors.lastname: Camargo
authors.forename: Camila Almeida
authors.initials: CA
authors.lastname: Camargo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoyama
authors.forename: Silvio Cesar
authors.initials: SC
authors.lastname: Miranda
authors.forename: Bread
authors.initials: B
authors.lastname: Cruz
authors.forename: Maria Cristina Cintra
authors.initials: MC
authors.lastname: Gomes Marcondes
authors.forename: Heidi
authors.initials: H
authors.lastname: Dolder
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000818:Animals; D031170:Arctium / Q000737:chemistry*; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010940:Plant Proteins / Q000097:blood / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry*; D020011:Protective Agents / Q000494:pharmacology*; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D010936:Plant Extracts; D010940:Plant Proteins; D020011:Protective Agents; D002104:Cadmium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D019256:Cadmium Chloride