title: Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.
abstract: Pancreatic cancer is a highly lethal disease with a poor prognosis characterized by local and systemic disease progression. Both radiation and chemotherapy play important roles in the management of this disease. However, in order to improve standard therapy many molecularly targeted agents are being developed. Glycogen synthase kinase 3β (GSK3β) participates in a multitude of cellular processes and is a newly proposed therapeutic target in pancreatic cancer. This review will discuss both the oncogenic and tumor suppressor functions of GSK3β in pancreatic cancer with an emphasis on the roles of GSK3β in tumor cell survival and sensitivity to radiation and chemotherapy.
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical School, USA.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical School, USA.
authors.forename: Mahaveer S
authors.initials: MS
authors.lastname: Bhojani
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Edgar
authors.initials: E
authors.lastname: Ben-Josef
authors.affiliation: Radiation Oncology, Norton Cancer Institute, Louisville, KY, 40202, USA.
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Spalding
authors.affiliation: Biostatistics Core, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA.
authors.forename: Rork
authors.initials: R
authors.lastname: Kuick
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical School, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical School, USA.
authors.forename: Meredith A
authors.initials: MA
authors.lastname: Morgan
keywords: GSK3β; Pancreatic cancer; Radiation; c-Met