title: A review of the evidence to inform pneumococcal vaccine recommendations for risk groups aged 2 years and older.
abstract: For decades, vaccination with the 23-valent polysaccharide pneumococcal vaccine (PPV23) has been available for risk groups aged ⩾2 years to prevent invasive pneumococcal disease (IPD). Recently, a 13-valent pneumococcal conjugated vaccine (PCV13) has been licensed for use in all age groups. PCV13 may induce better protection than PPV23 because of different immunogenic properties. This called for a revision of vaccine recommendations for risk groups. We therefore reviewed literature on risk groups for IPD, and effectiveness and safety of pneumococcal vaccines and supplemented that with information from public health institutes, expert consultations and data on IPD epidemiology. We included 187 articles. We discuss the implications of the heterogenic vulnerability for IPD within and between risk groups, large indirect effects of childhood immunization, and limited knowledge on additional clinical benefits of PCV13 in combination with PPV23 for the Norwegian recommendations. These are now step-wise and consider the need for vaccination, choice of pneumococcal vaccines, and re-vaccination interval by risk group.
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: A
authors.initials: A
authors.lastname: Steens
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: D F
authors.initials: DF
authors.lastname: Vestrheim
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: I S
authors.initials: IS
authors.lastname: Aaberge
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: B S
authors.initials: BS
authors.lastname: Wiklund
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: J
authors.initials: J
authors.lastname: Storsaeter
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: M A
authors.initials: MA
authors.lastname: Riise Bergsaker
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: K
authors.initials: K
authors.lastname: Rønning
authors.affiliation: Division of Infectious Disease Control,Norwegian Institute of Public Health,Oslo,Norway.
authors.forename: E
authors.initials: E
authors.lastname: Furuseth
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006291:Health Policy; D006801:Humans; D009664:Norway / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D018074:Vaccines, Conjugate
chemical_list: C538862:13-valent pneumococcal vaccine; C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate