title: Could clomiphene kindle acute manic episode in a male patient? A case report.
abstract: Psychiatric adverse effects associated with the use of clomiphene are relatively uncommon. Though case reports link mood swings to be associated with clomiphene, it is not known to be associated with a syndromal affective episode. Being a selective estrogen receptor modulator, clomiphene affects the hypothalamus-pituitary-gonadal axis and can have potential neuropsychiatric effects in vulnerable persons. Herein we report a case of clomiphene-induced manic episode in a known bipolar male patient.
authors.affiliation: Department of Psychiatry, I.H.B.A.S, Dilshad Garden, Delhi, India- 110095. Electronic address: pallavisinha0102@gmail.com.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sinha
authors.affiliation: Department of Psychiatry, I.H.B.A.S, Dilshad Garden, Delhi, India- 110095. Electronic address: drgargamit@yahoo.com.
authors.forename: Amit
authors.initials: A
authors.lastname: Garg
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000150:complications; D002996:Clomiphene / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D002996:Clomiphene
keywords: Bipolar disorder; Clomiphene; Male; Manic episode