title: Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.
abstract: As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail.
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul 140-742, Korea.
authors.forename: Yonghwan
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D045566:DNA, Cruciform / Q000235:genetics / Q000378:metabolism; D005199:Fanconi Anemia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D009154:Mutation; D011485:Protein Binding; D025941:Protein Interaction Mapping; D045522:Recombinases / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D059505:Telomere Homeostasis
chemical_list: D045566:DNA, Cruciform; D045522:Recombinases; C542319:SLX4 protein, human
keywords: Holliday junction; ICL repair; SLX4/FANCP; fanconi anemia; telomere maintenance