title: [Lp-PLA2 and sPLA2: cardiovascular biomarkers].
abstract: Phospholipases A2 (PLA2) belong to a superfamily of enzymes that catalyze the hydrolysis of glycerophospholipids at the sn-2 position, producing nonesterified fatty acids and lysophospholipids. Many experimental studies have shown that PLA2 are involved in lipid metabolism and immuno-inflammatory response and participate in the development of atherosclerosis. In humans, therapeutic approaches based on the inhibition of PLA2 are currently in development. This review summarizes human studies regarding the prognostic value of two members of the family of PLA2, Lp-PLA2 (lipoprotein-associated PLA2) and sPLA2 (secretory PLA2), in cardiovascular diseases.
authors.affiliation: Inserm U970, Paris-centre de recherche cardiovasculaire (PARCC), université Paris Descartes, 56, rue Leblanc, 75015 Paris, France - Service de réanimation médicale, hôpital Saint-Antoine, Assistance publique-hôpitaux de Paris, Paris, France.
authors.forename: Hafid
authors.initials: H
authors.lastname: Ait-Oufella
authors.affiliation: Inserm U970, Paris-centre de recherche cardiovasculaire (PARCC), université Paris Descartes, 56, rue Leblanc, 75015 Paris, France - Université de Cambridge, département de médecine, Addenbrooke's hospital, Cambridge CB2 2QQ, Royaume-Uni.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Mallat
authors.affiliation: Inserm U970, Paris-centre de recherche cardiovasculaire (PARCC), université Paris Descartes, 56, rue Leblanc, 75015 Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Tedgui
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000378:metabolism*; D050197:Atherosclerosis / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D054467:Phospholipases A2 / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase