title: Antifungal amphidinol 18 and its 7-sulfate derivative from the marine dinoflagellate Amphidinium carterae.
abstract: Two new polyketides of the amphidinol family, amphidinol 18 (AM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae. Structure elucidation of the two polyoxygenated molecules has been accomplished by extensive use of spectroscopic and spectrometric techniques. AM18 exhibited antifungal activity against Candida albicans at 9 μg/mL.
authors.affiliation: CNR, Istituto di Chimica Biomolecolare , Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy.
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Nuzzo
authors.forename: Adele
authors.initials: A
authors.lastname: Cutignano
authors.forename: Angela
authors.initials: A
authors.lastname: Sardo
authors.forename: Angelo
authors.initials: A
authors.lastname: Fontana
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004141:Dinoflagellida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011714:Pyrans / Q000737:chemistry; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification*; D000095722:Amphidinols
chemical_list: D000475:Alkenes; D000935:Antifungal Agents; D061065:Polyketides; D011714:Pyrans; D013463:Sulfuric Acid Esters; C000591088:amphidinol 18; D000095722:Amphidinols; C000591089:amphidinol 19; C438973:amphidinol 3