title: Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis: pathophysiological and technical considerations.
abstract: BACKGROUND
  While non-invasive ventilation aimed at avoiding intubation has become the modality of choice to treat mild to moderate acute respiratory acidosis, many severely acidotic patients (pH <7.20) still need intubation. Extracorporeal veno-venous CO2 removal (ECCO2R) could prove to be an alternative. The present animal study tested in a systematic fashion technical requirements for successful ECCO2R in terms of cannula size, blood and sweep gas flow.
  
  
  METHODS
  ECCO2R with a 0.98 m(2) surface oxygenator was performed in six acidotic (pH <7.20) pigs using either a 14.5 French (Fr) or a 19Fr catheter, with sweep gas flow rates of 8 and 16 L/minute, respectively. During each experiment the blood flow was incrementally increased to a maximum of 400 mL/minute (14.5Fr catheter) and 1000 mL/minute (19Fr catheter).
  
  
  RESULTS
  Amelioration of severe respiratory acidosis was only feasible when blood flow rates of 750 to 1000 mL/minute (19Fr catheter) were used. Maximal CO2-elimination was 146.1 ± 22.6 mL/minute, while pH increased from 7.13 ± 0.08 to 7.41 ± 0.07 (blood flow of 1000 mL/minute; sweep gas flow 16 L/minute). Accordingly, a sweep gas flow of 8 L/minute resulted in a maximal CO2-elimination rate of 138.0 ± 16.9 mL/minute. The 14.5Fr catheter allowed a maximum CO2 elimination rate of 77.9 mL/minute, which did not result in the normalization of pH.
  
  
  CONCLUSIONS
  Veno-venous ECCO2R may serve as a treatment option for severe respiratory acidosis. In this porcine model, ECCO2R was most effective when using blood flow rates ranging between 750 and 1000 mL/minute, while an increase in sweep gas flow from 8 to 16 L/minute had less impact on ECCO2R in this setting.
authors.forename: Christian
authors.initials: C
authors.lastname: Karagiannidis
authors.forename: Kristin Aufm
authors.initials: KA
authors.lastname: Kampe
authors.forename: Fernando Suarez
authors.initials: FS
authors.lastname: Sipmann
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.forename: Goran
authors.initials: G
authors.lastname: Hedenstierna
authors.forename: Wolfram
authors.initials: W
authors.lastname: Windisch
authors.forename: Thomas
authors.initials: T
authors.lastname: Mueller
mesh_terms: D000142:Acidosis, Respiratory / Q000097:blood / Q000628:therapy*; D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D004195:Disease Models, Animal; D005112:Extracorporeal Circulation / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D010313:Partial Pressure; D013552:Swine
chemical_list: D002245:Carbon Dioxide