title: [On the possibilities of correction of changes of the gastrointestinal tract microbiota in patients with lung cancer treated receiving chemotherapy].
abstract: The aim of the study was the improvement of technologies of treatment of patients with the lung cancer receiving chemotherapy on the basis of using with the complex therapy of the combined probiotic based on the Bacillus subtilis strain.
  
  
  METHODS
  30 patients with the lung cancer receiving the first and second line of the first cycle of chemotherapy were included. The age of patients varied from 49 to 73 years, the average duration of the disease was 1 year. Patients of the main group (n = 21) received the combined probiotic based on the Bacillus subtilis strain together with the chemotherapy course. Patients of control group (n = 9) received only chemotherapeutic preparations. All patients were observed before and after treatment: the standardized inquiry for detection of intestinal complaints, microbiological research of feces (definition of qualitative and quantitative characteristics of gut microbiota), the research of metabolites of intestinal microorganisms in blood by the method of the gas-liquid chromatography - mass-spectrometry by G. A. Osipov's method. The efficiency of probiotic therapy was evaluated by results of studied indicators dynamics.
  
  
  RESULTS
  Main symptoms of the intestinal dyspepsia were observed in patients with the lung cancer receiving chemotherapy such as constipation and intestinal microflora violations (decreased quantity of Lactobacillus, Bifidobacterium, Bacteroides and increased quantity of different pathogenic microorganisms). It was noted decreased rate of intestinal dyspepsia symptoms and improvement of intestinal microflora composition after the treatment course by the combined probiotic based on the Bacillus subtilis strain.
  
  
  CONCLUSIONS
  Using of probiotic medicines with the chemotherapy in lung cancer patients is promising to reduce the frequency of gastrointestinal complaints and prevent deterioration of the gut microflora.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Serkova
authors.forename: M A
authors.initials: MA
authors.lastname: Urtenova
authors.forename: E I
authors.initials: EI
authors.lastname: Tkachenko
authors.forename: E B
authors.initials: EB
authors.lastname: Avalueva
authors.forename: S V
authors.initials: SV
authors.lastname: Orlov
authors.forename: S V
authors.initials: SV
authors.lastname: Ivanov
authors.forename: E A
authors.initials: EA
authors.lastname: Orishak
authors.forename: E V
authors.initials: EV
authors.lastname: Skazyvaeva
mesh_terms: D000368:Aged; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006094:Gram-Positive Bacteria; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage*