title: Moderate-intensity interval training increases serum brain-derived neurotrophic factor level and decreases inflammation in Parkinson's disease patients.
abstract: It has been demonstrated that physical training increases serum brain-derived neurotrophic factor (BDNF) in healthy people. The aim of this study was to establish the effect of physical training on the basal serum level of the BDNF in the Parkinson's disease patients (PD patients) in relation to their health status. Twelve PD patients (mean ± S.E.M: age 70 ± 3 years; body mass 70 ± 2 kg; height 163 ± 3 cm) performed a moderate-intensity interval training (three 1-hour training sessions weekly), lasting 8 weeks. Basal serum BDNF in the PD patients before training amounted to 10,977 ± 756 pg x mL(-1) and after 8 weeks of training it has increased to 14,206 ± 1256 pg x mL(-1) (i.e. by 34%, P=0.03). This was accompanied by an attenuation of total Unified Parkinson's Disease Rating Scale (UPDRS) (P=0.01). The training resulted also in a decrease of basal serum soluble vascular cell adhesion molecule 1 (sVCAM-1) (P=0.001) and serum tumor necrosis factor-α (TNF-α) (P=0.03) levels. We have concluded that the improvement of health status of the Parkinson's disease patients after training could be related to the increase of serum BDNF level caused by the attenuated inflammation in those patients.
authors.affiliation: Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Cracow, Poland. jerzy.zoladz@awf.krakow.pl.
authors.forename: J A
authors.initials: JA
authors.lastname: Zoladz
authors.forename: J
authors.initials: J
authors.lastname: Majerczak
authors.forename: E
authors.initials: E
authors.lastname: Zeligowska
authors.forename: J
authors.initials: J
authors.lastname: Mencel
authors.forename: A
authors.initials: A
authors.lastname: Jaskolski
authors.forename: A
authors.initials: A
authors.lastname: Jaskolska
authors.forename: J
authors.initials: J
authors.lastname: Marusiak
mesh_terms: D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008297:Male; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000097:blood* / Q000378:metabolism / Q000473:pathology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor