title: [Treating chronic persistent bronchial asthma children with abnormal myocardial enzyme spectrum by Yupingfeng powder: an efficacy observation].
abstract: OBJECTIVE
  To observe the clinical efficacy of treating chronic persistent bronchial asthma (CPBA) children with abnormal myocardial enzyme spectrum (AMES) by Yupingfeng Powder (YP) combined routine therapy.
  
  
  METHODS
  From January 2010 to December 2012, 156 CPBA children patients with AMES were randomly assigned to the treatment group (80 cases) and the control group (76 cases). All patients received routine treatment (inhaled corticosteroids and/or leukotriene regulator). Besides, those in the treatment group took YP. The treatment duration was 3 months. The scores of children asthma control test (C-ACT), pulmonary function (FEV,% and PEF%), myocardial enzyme spectrum were observed before and after treatment, and 3 months before and after treatment. The myocardial enzyme spectrum of 40 healthy children at the baby clinics during the same period were recruited as the control.
  
  
  RESULTS
  Compared with the control group, creatine kinase isoenzyme (CK-MB), creatine kinase(CK), and lactate dehydrogenase (LDH) increased in the two treatment groups (P <0.01), but there was no statistical difference in AST (P >0.05). Compared with before treatment in the same group, CK-MB, CK, LDH, and AST decreased in the treatment group after treatment and 3 months after treatment (P <0.01). CK-MB, CK, LDH, and AST decreased in the control group 3 months after treatment (P <0.01, P <0.05).Compared with after treatment, CK decreased in the control group 3 months after treatment (P <0.01). C-ACT score, FEV(1),%, and PEF% all increased in the two groups after treatment and 3 months after treatment (P <0.01, P <0.05). Compared with after treatment in the same group, CK decreased in the control group 3 months after treatment (P <0. 01). Compared with the control group in the same period, post-treatment CK-MB and CK decreased (P <0. 01, P <0. 05), while post-treatment C-ACT score, FEV, %, and PEF% increased (P <0.05) in the treatment group (P <0.05).
  
  
  CONCLUSIONS
  YP could strengthen specific and non-specific immunity of the organism, and improve clinical symptoms and the level of myocardial enzyme spectrum.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Chen
authors.forename: Hua-Jun
authors.initials: HJ
authors.lastname: Li
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Zhang
authors.forename: Hang-Hu
authors.initials: HH
authors.lastname: Zhang
authors.forename: Hang-yuan
authors.initials: HY
authors.lastname: Guo
mesh_terms: D001249:Asthma / Q000628:therapy*; D002648:Child; D002908:Chronic Disease / Q000628:therapy; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*
chemical_list: D004365:Drugs, Chinese Herbal; C532967:yupingfeng; D007770:L-Lactate Dehydrogenase; D052279:Creatine Kinase, MB Form