title: Automated synthesis of backbone protected peptides.
abstract: The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challenging target sequences.
authors.affiliation: MRC National Institiute for Medical Research, The Ridgeway, London, UK. joffer@nimr.mrc.ac.uk.
authors.forename: Abu-Baker M
authors.initials: AB
authors.lastname: Abdel-Aal
authors.forename: George
authors.initials: G
authors.lastname: Papageorgiou
authors.forename: Martin
authors.initials: M
authors.lastname: Quibell
authors.forename: John
authors.initials: J
authors.lastname: Offer
mesh_terms: D000595:Amino Acid Sequence; D001331:Automation; D006388:Hemagglutinins / Q000737:chemistry / Q000378:metabolism; D009975:Orthomyxoviridae / Q000378:metabolism; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006388:Hemagglutinins; D010455:Peptides