title: Fly wing vein patterns have spatial reproducibility of a single cell.
abstract: Developmental processes in multicellular organisms occur in fluctuating environments and are prone to noise, yet they produce complex patterns with astonishing reproducibility. We measure the left-right and inter-individual precision of bilaterally symmetric fly wings across the natural range of genetic and environmental conditions and find that wing vein patterns are specified with identical spatial precision and are reproducible to within a single-cell width. The early fly embryo operates at a similar degree of reproducibility, suggesting that the overall spatial precision of morphogenesis in Drosophila performs at the single-cell level. Could development be operating at the physical limit of what a biological system can achieve?
authors.affiliation: Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Laurent
authors.initials: L
authors.lastname: Abouchar
authors.affiliation: Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Mariela D
authors.initials: MD
authors.lastname: Petkova
authors.affiliation: Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Steinhardt
authors.affiliation: Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA tg2@princeton.edu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gregor
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D049108:Cell Enlargement; D003198:Computer Simulation; D004330:Drosophila / Q000166:cytology* / Q000254:growth & development*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D015233:Models, Statistical; D012680:Sensitivity and Specificity; D014680:Veins / Q000166:cytology* / Q000254:growth & development*; D014921:Wings, Animal / Q000098:blood supply* / Q000166:cytology*
keywords: Drosophila; development; fly wings; pattern formation; precision; symmetry