title: HIV-related NK/T-cell lymphoma in the brain relapsed during intensive chemotherapy but regressed after chemotherapy discontinuation: the importance of maintaining cellular immunity.
abstract: This study reports a case of human immunodeficiency virus (HIV)-related natural killer/T-cell lymphoma with an unexpected clinical course. The lymphoma cells were positive for Epstein-Barr virus and the primary nodal lesions regressed after chemotherapy and combined antiretroviral therapy (c-ART); however, brain metastasis progressed along with a reduction in the CD8+ T-cell count. Chemotherapy was discontinued and the patient was treated with c-ART alone, resulting in regression of the brain lesions and recovery of the CD8+ T-cell count. This case highlights the importance of maintaining anti-tumor immunity in patients with HIV-related lymphoma.
authors.affiliation: Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1 Minami-Machi Minatojima, Chuo-Ku, Kobe, 650-047, Japan, yosuke.nagahata@gmail.com.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nagahata
authors.forename: Aiko
authors.initials: A
authors.lastname: Kato
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Imai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D018655:Lymphocyte Count; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D044966:Anti-Retroviral Agents