title: Iron and multiple sclerosis.
abstract: Iron is essential for normal cellular functioning of the central nervous system. Abnormalities in iron metabolism may lead to neuronal death and abnormal iron deposition in the brain. Several studies have suggested a link between brain iron deposition in normal aging and chronic neurologic diseases, including multiple sclerosis (MS). In MS, it is still not clear whether iron deposition is an epiphenomenon or a mediator of disease processes. In this review, the role of iron in the pathophysiology of MS will be summarized. In addition, the importance of conventional and advanced magnetic resonance imaging techniques in the characterization of brain iron deposition in MS will be reviewed. Although there is currently not enough evidence to support clinical use of iron chelation in MS, an overview of studies of iron chelation or antioxidant therapies will be also provided.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Brookline, MA, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Stankiewicz
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Brookline, MA, USA.
authors.forename: Mohit
authors.initials: M
authors.lastname: Neema
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Brookline, MA, USA. Electronic address: antonia@bwh.harvard.edu.
authors.forename: Antonia
authors.initials: A
authors.lastname: Ceccarelli
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D000975:Antioxidants / Q000627:therapeutic use; D001921:Brain / Q000166:cytology / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D007502:Iron Chelating Agents; D007501:Iron
keywords: Antioxidant; Brain; Chelation; Iron; Multiple sclerosis