title: [Survival analysis and recommendation of subdividing M1 stage according to metastatic status of colorectal cancer].
abstract: OBJECTIVE
  To subdivide the M1 stage of patients to predict better survival groups and assess the predictive factors of prognosis to select personalized cancer treatments.
  
  
  METHODS
  From the records of 666 colorectal cancer cases treated at our hospital during January 1995 to December 2010, we analyzed the site of metastases, number of metastases, size of hepatic metastatic tumor and corresponding treatments. According to the results, we made recommendations for subdividing the M1 stage to guide individualized treatments.
  
  
  RESULTS
  The metastatic median survival of liver metastasis and non-liver metastasis were 18.7 vs 22.9 months (P = 0.082). And the median survival of single organ metastasis, double organ metastasis and multiple organ metastasis were 24.8 vs 15.6 vs 10.9 months, (P < 0.01).With no more than 3 liver lesions, the patients received operation or ablation therapy plus chemotherapy and their median survival was longer than those on chemotherapy only (49.6 vs 22.3 months, P < 0.01).
  
  
  CONCLUSIONS
  According to metastatic characteristics, different clinical features and treatments result in significantly different survivals and prognoses in metastatic colorectal cancer patients.
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Fangming
authors.initials: F
authors.lastname: Wu
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Li
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Zilin
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
authors.forename: Yangkui
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Center of Medical Image & Image Guided Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Guangzhou 510060, China. Email:wuph@sysucc.org.cn.
authors.forename: Peihong
authors.initials: P
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D055815:Young Adult