title: Massive splenic infarction and portal vein thrombosis in children with chronic myeloid leukemia.
abstract: Massive splenic infarction and portal vein thrombosis (PVT) due to chronic myeloid leukemia (CML) is extremely rare. We describe 2 children who were presented with massive splenic infarction and PVT in the course of CML. Massive splenic infarction and PVT treated with splenectomy in one and with medical treatment in another in whom PVT resolved by cytoreductive treatment, led to downsizing of spleen or splenectomy. Splenic infarct and PVT should be considered in CML patients with long-lasting severe abdominal pain despite appropriate medical attempts. Splenectomy should be spared for persistent symptoms and complications.
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Tekin
authors.initials: T
authors.lastname: Aksu
authors.forename: Arzu Y
authors.initials: AY
authors.lastname: Erdem
authors.forename: Ali
authors.initials: A
authors.lastname: Fettah
authors.forename: Dilek
authors.initials: D
authors.lastname: Kaçar
authors.forename: Zekai
authors.initials: Z
authors.lastname: Avci
authors.forename: Nese
authors.initials: N
authors.lastname: Yarali
authors.forename: Bahattin
authors.initials: B
authors.lastname: Tunc
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D008297:Male; D011169:Portal Vein; D012074:Remission Induction; D012720:Severity of Illness Index; D013156:Splenectomy; D013159:Splenic Infarction / Q000209:etiology* / Q000601:surgery; D013927:Thrombosis / Q000209:etiology* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents