title: Primary gastrointestinal stromal tumor of the prostate: A case report and literature review.
abstract: Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, the mass was separated from the rectum serosa and exhibited a high mitotic count (8/50 high-power fields). The results of immunohistochemical staining showed positive immunoreactivity for cluster of differentiation (CD)117 (c-kit), CD34 and DOG1 in the tumor. On mutation analysis, loss of heterozygosity of the c-kit gene was observed in the prostatic EGIST; however, the platelet-derived growth factor receptor-α (PDGFRA) gene was considered to be normal. Therefore, as EGIST of the prostate is rare, there is a requirement for the confirmation of the diagnosis to be based on immunohistochemistry and mutation analysis (of c-kit and PDGFRA).
authors.affiliation: Department of Urology, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P.R. China ; Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Sulai
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Rheumatology, Ningbo Medical Center Li Huili Hospital, Ningbo, Zhejiang 315040, P.R. China.
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Urology, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Qi
authors.affiliation: Department of Urology, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Xiongbing
authors.initials: X
authors.lastname: Zu
authors.affiliation: Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Anesthesia, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Jingshi
authors.initials: J
authors.lastname: Liu
keywords: c-kit; extragastrointestinal stromal tumors; platelet-derived growth factor receptor-α; prostate