title: Advances in alginate gel microencapsulation of therapeutic cells.
abstract: Rapid developments in the therapeutic applications of genetically engineered cells and stem cell research have increased the possibilities of addressing some pathologies by grafting therapeutic cells. Immunoprotective encapsulation of such therapeutic cells is often essential for their survival and function. Hydrogels provide a bioteolerable matrix for cellular encapsulation and support subsequent graft survival and function. The naturally occurring marine polysaccharide, alginate, is the hydrogel of choice for most applications. However, long-term graft survival is affected by the mechanical instability of alginate and adverse immune reaction to its grafting. So, a variety of modifications have been developed to enhance the physicochemical properties and biotolerance of alginate hydrogels. We highlight the developments in alginate hydrogel microencapsulation of therapeutic cells.
authors.affiliation: Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire; Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire.
authors.forename: Barjor
authors.initials: B
authors.lastname: Gimi
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH; Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
authors.forename: Krishnamurthy V
authors.initials: KV
authors.lastname: Nemani
mesh_terms: D000464:Alginates; D000818:Animals; D002214:Capsules; D060846:Cell Engineering; D002460:Cell Line; D064987:Cell- and Tissue-Based Therapy; D006224:Cricetinae; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
chemical_list: D000464:Alginates; D002214:Capsules; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid