title: Salvia miltiorrhizaextracts protect against retinal injury in a rat glaucoma model.
abstract: Glaucoma is a serious progressive degenerative disorder of the eye that leads to the continuous loss of retinal ganglion cells. Traditional Chinese medicine provides an important source for new drug screening and identification. The present study usedSalvia miltiorrhiza(Danshen) extracts to examine the potential neuroprotective effects for the eye in a rat model of experimental glaucoma. The results of the study indicated thatSalvia miltiorrhizaextracts were unable to prevent intraocular pressure increase in the laser-induced glaucoma model, but the treatment did reduce cell loss during glaucoma progression. Therefore, the results provide the basis for the development of a novel therapeutic agent that exhibits neuroprotective effects against glaucoma. In the future, further studies are required to purify the extracts and determine the effective bioactive components ofSalvia miltiorrhiza.
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
authors.forename: Guanfang
authors.initials: G
authors.lastname: Su
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
authors.forename: Lili
authors.initials: L
authors.lastname: Nie
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
keywords: Danshen; Salvia miltiorrhiza; glaucoma; neuroprotection; retina; retinal ganglion cell; traditional Chinese medicine