title: Future treatment in patients with chronic obstructive pulmonary disease: to reverse or not to reverse steroid resistance-that is the question.
authors.affiliation: Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: l.koenderman@umcutrecht.nl.
authors.forename: Leo
authors.initials: L
authors.lastname: Koenderman
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Edwin R
authors.initials: ER
authors.lastname: Chilvers
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000631:Aminopyridines / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D003521:Cyclopropanes / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D004351:Drug Resistance / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D058988:Phosphodiesterase 4 Inhibitors / Q000494:pharmacology*
chemical_list: D000305:Adrenal Cortex Hormones; D000631:Aminopyridines; D001549:Benzamides; D003521:Cyclopropanes; D058988:Phosphodiesterase 4 Inhibitors; D003907:Dexamethasone; C517734:roflumilast N-oxide
keywords: Roflumilast; chronic obstructive pulmonary disease; neutrophils; oxidative stress; steroid resistance; steroids