title: Laboratory to community: chemoprevention is the answer.
abstract: In the current issue, Johnson and colleagues present exciting results, using biomarkers involved in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis, as an example of a conceptual framework to target mechanisms of action in developing chemopreventive agents. Their innovative approach offers considerable promise for a field that has long been neglected. Proof-of-principle was demonstrated using a synthetic triterpenoid (CDDO-Im), which activates Nrf2 signal transduction pathway, inhibits formation of AFB1-induced DNA adducts and neoplastic hepatic foci, and alters the expression of genes associated with aflatoxin-mediated toxicity.
authors.affiliation: Authors' Affiliation: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, District of Columbia olden.kenneth@epa.gov.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Olden
authors.affiliation: Authors' Affiliation: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, District of Columbia.
authors.forename: Suryanarayana V
authors.initials: SV
authors.lastname: Vulimiri
mesh_terms: D016604:Aflatoxin B1 / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control*; D018736:DNA Adducts / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D051549:Glutathione S-Transferase pi / Q000378:metabolism*; D007093:Imidazoles / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control*; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: C472829:1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole; D014408:Biomarkers, Tumor; D018736:DNA Adducts; D007093:Imidazoles; C072611:aflatoxin B1-DNA adduct; D009828:Oleanolic Acid; D016604:Aflatoxin B1; D051549:Glutathione S-Transferase pi; C496558:Gstp1 protein, rat