title: Effect of salidroside on lung injury by upregulating peroxisome proliferator-activated receptor γ expression in septic rats.
abstract: Successful drug treatment for sepsis-related acute lung injury (ALI) remains a major clinical problem. Thus, the aim of the present study was to investigate the beneficial effects of salidroside on ameliorating cecal ligation and puncture (CLP)-induced lung inflammation. Rats underwent CLP surgery to induce ALI and 800 mg/kg salidroside (i.v.) was administered 24 h after the CLP challenge. Subsequently, biochemical changes in the blood and lung tissues, as well as morphological and histological alterations in the lungs, that were associated with inflammation and injury were analysed. CLP was shown to significantly increase the serum levels of plasma tumour necrosis factor-α and interleukin-6, -1β and-10. In addition, CLP increased pulmonary oedema, thickened the alveolar septa and caused inflammation in the lung cells. These changes were ameliorated by the administration of 800 mg/kg salidroside (i.v.) 24 h after the CLP challenge. This post-treatment drug administration also significantly attenuated the lipopolysaccharide-induced activation of nuclear factor-κβ and increased the release of peroxisome proliferator-activated receptor γ in the lung tissue. Therefore, salidroside administered following the induction of ALI by CLP significantly prevented and reversed lung tissue injuries. The positive post-treatment effects of salidroside administration indicated that salidroside may be a potential candidate for the management of lung inflammation in CLP-induced endotoxemia and septic shock.
authors.affiliation: Department of Emergency, The First Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Liu
authors.affiliation: Surgical Intensive Care Unit, The Second Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650106, P.R. China.
authors.forename: Mei-Xian
authors.initials: MX
authors.lastname: Su
authors.affiliation: Department of Emergency, The First Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
authors.forename: Lan-Fang
authors.initials: LF
authors.lastname: Qin
authors.affiliation: Department of Infectious Diseases, Yan'an Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650051, P.R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Infectious Diseases, Yan'an Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650051, P.R. China.
authors.forename: Mao-Li
authors.initials: ML
authors.lastname: Tian
authors.affiliation: Department of Emergency, The First Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Emergency, The First Hospital Affiliated To Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Wang
keywords: cecal ligation and puncture; lung injury; peroxisome proliferator-activated receptor γ; rat; salidroside; sepsis