title: Gefitinib and afatinib treatment in an advanced non-small cell lung cancer (NSCLC) patient undergoing hemodialysis.
abstract: Renal failure in cancer patients is not a rare clinical condition and often contraindicates anticancer drug treatment; moreover, chemotherapeutic drugs are frequently identified as possible iatrogenic cause of renal failure. Molecular therapies, when appropriate, could represent a therapeutic option for cancer patients with severe renal disease, but the lack of knowledge in this field, at present, limits their use in patients undergoing dialysis. Herein we describe a case, at our knowledge the first reported, of a patient with advanced lung adenocarcinoma on maintenance hemodialysis treated with gefitinib and then with afatinib; we also reviewed the literature on epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) used in NSCLC patients with concomitant renal impairment.
authors.affiliation: Medical Oncology Unit, University Hospital of Parma, Parma, Italy melissa.bersanelli@alice.it.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bersanelli
authors.affiliation: Medical Oncology Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Tiseo
authors.affiliation: Medical Oncology Unit, Hospitals of Carpi and Mirandola, Modena, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Artioli
authors.affiliation: Nephrology and Dialysis Unit, University Hospital of Modena, Modena, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lucchi
authors.affiliation: Medical Oncology Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ardizzoni
mesh_terms: D000077716:Afatinib; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D011799:Quinazolines / Q000008:administration & dosage; D006435:Renal Dialysis
chemical_list: D011799:Quinazolines; D000077716:Afatinib; D000077156:Gefitinib
keywords: Afatinib; EGFR-TKI; NSCLC; dialysis; gefitinib; hemodialysis; renal failure