title: Literome: PubMed-scale genomic knowledge base in the cloud.
abstract: BACKGROUND
  Advances in sequencing technology have led to an exponential growth of genomics data, yet it remains a formidable challenge to interpret such data for identifying disease genes and drug targets. There has been increasing interest in adopting a systems approach that incorporates prior knowledge such as gene networks and genotype-phenotype associations. The majority of such knowledge resides in text such as journal publications, which has been undergoing its own exponential growth. It has thus become a significant bottleneck to identify relevant knowledge for genomic interpretation as well as to keep up with new genomics findings.
  
  
  RESULTS
  In the Literome project, we have developed an automatic curation system to extract genomic knowledge from PubMed articles and made this knowledge available in the cloud with a Web site to facilitate browsing, searching and reasoning. Currently, Literome focuses on two types of knowledge most pertinent to genomic medicine: directed genic interactions such as pathways and genotype-phenotype associations. Users can search for interacting genes and the nature of the interactions, as well as diseases and drugs associated with a single nucleotide polymorphism or gene. Users can also search for indirect connections between two entities, e.g. a gene and a disease might be linked because an interacting gene is associated with a related disease.
  
  
  METHODS
  Literome is freely available at literome.azurewebsites.net. Download for non-commercial use is available via Web services.
authors.affiliation: Microsoft Research, One Microsoft Way, Redmond, WA 98052, USA.
authors.forename: Hoifung
authors.initials: H
authors.lastname: Poon
authors.affiliation: Microsoft Research, One Microsoft Way, Redmond, WA 98052, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Quirk
authors.affiliation: Microsoft Research, One Microsoft Way, Redmond, WA 98052, USA.
authors.forename: Charlie
authors.initials: C
authors.lastname: DeZiel
authors.affiliation: Microsoft Research, One Microsoft Way, Redmond, WA 98052, USA.
authors.forename: David
authors.initials: D
authors.lastname: Heckerman
mesh_terms: D000465:Algorithms; D001331:Automation; D019295:Computational Biology / Q000379:methods*; D056726:Genetic Association Studies; D016678:Genome; D023281:Genomics / Q000379:methods*; D005838:Genotype; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D039781:PubMed; D012984:Software