title: Combined topical application of a regenerative agent with a bandage contact lens for the treatment of persistent epithelial defects.
abstract: OBJECTIVE
  The aim of this study was to report 3 cases of persistent epithelial defects (PEDs) successfully treated with the combined topical application of a regenerative agent (RGTA; Cacicol20, OTR3, Paris, France) with a bandage contact lens (BCL).
  
  
  METHODS
  This is a case series.
  
  
  RESULTS
  Three patients suffering from a PED for 4-8 weeks and unresponsive to conventional therapy were treated with the combined application of an RGTA (Cacicol20) and a silicone hydrogel BCL. The PED healed in all patients after 4-21 days, and no side effects were noted.
  
  
  CONCLUSIONS
  The combination of an RGTA (Cacicol20) with a BCL seems to be an effective treatment for PED.
authors.affiliation: *Faculty of Medicine, Vardinoyiannion Eye Institute of Crete (VEIC), University of Crete, Heraklion, Crete, Greece; and †Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.forename: Dimitrios A
authors.initials: DA
authors.lastname: Liakopoulos
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grentzelos
authors.forename: Vasilios F
authors.initials: VF
authors.lastname: Diakonis
authors.forename: Nektarios E
authors.initials: NE
authors.lastname: Klados
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tsoulnaras
authors.forename: Miltiadis K
authors.initials: MK
authors.lastname: Tsilimbaris
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Pallikaris
mesh_terms: D000328:Adult; D047070:Bandages, Hydrocolloid; D003131:Combined Modality Therapy; D003261:Contact Lenses; D003316:Corneal Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D019573:Epithelium, Corneal / Q000473:pathology*; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006025:Glycosaminoglycans; C533322:OTR4120