title: Validation of the Greek OSD-6 quality of life questionnaire in children undergoing polysomnography.
abstract: OBJECTIVE
  OSD-6 is a disease specific questionnaire for pediatric obstructive sleep apnea (OSA). The aims of this study were to validate OSD-6 in Greek language and correlate OSD-6 with polysomnography results.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  OSD-6 questionnaire was translated to Greek and back to English. A prospective study was conducted on children undergoing overnight polysomnography due to snoring and disrupted sleep. Test-retest evaluation was carried out. Internal consistency and test-retest reliability were evaluated. Validity was assessed by exploring correlations between OSD-6 scores and apnea-hypopnea index (AHI), and by comparing total scores of OSA and non-OSA groups. Responsiveness was assessed by comparing preoperative to postoperative total scores in OSA children who underwent adenotonsillectomy.
  
  
  RESULTS
  Test-retest evaluation of 91 subjects showed good internal consistency (Cronbach's alpha 0.860 for test and 0.873 for retest) and reliability (Pearson's correlation coefficients between test and retest scores: 0.751-0.546; p<0.01). Total and domains' OSD-6 scores and AHI were significantly correlated (Spearman's correlation coefficients: 0.277-0.630; p<0.01), while children with OSA had higher total OSD-6 score than those without OSA (median (interquartile range): 16 (11) vs. 10 (7), respectively; p<0.01), indicating good validity. Postoperative OSD-6 scores were significantly lower than preoperative (2.84 ± 3.21 vs. 15.42 ± 6.48, respectively; p<0.001), suggesting good responsiveness.
  
  
  CONCLUSIONS
  The Greek version of the OSD-6 questionnaire proved to be a valid instrument with satisfactory internal consistency, reliability, validity and responsiveness. Furthermore, in our study OSD-6 was significantly correlated to polysomnography results.
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Larissa, Greece. Electronic address: vlachanas@gmail.com.
authors.forename: Vasileios A
authors.initials: VA
authors.lastname: Lachanas
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
authors.forename: George K
authors.initials: GK
authors.lastname: Mousailidis
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
authors.forename: Charalampos E
authors.initials: CE
authors.lastname: Skoulakis
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papandreou
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Exarchos
authors.affiliation: Sleep Disorders Laboratory, University Hospital of Larissa, Greece.
authors.forename: Emmanouel I
authors.initials: EI
authors.lastname: Alexopoulos
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Larissa, Greece.
authors.forename: John G
authors.initials: JG
authors.lastname: Bizakis
mesh_terms: D000233:Adenoidectomy; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D011446:Prospective Studies; D011788:Quality of Life; D015203:Reproducibility of Results; D020181:Sleep Apnea, Obstructive / Q000523:psychology* / Q000601:surgery; D011795:Surveys and Questionnaires; D014068:Tonsillectomy; D014175:Translating
keywords: Greek; OSA; OSD-6; Pediatric obstructive sleep apnea; Polysomnography; Quality of life