title: Crystallin αB acts as a molecular guard in mouse decidualization: regulation and function during early pregnancy.
abstract: Although decidualization is crucial for the establishment of successful pregnancy, the molecular mechanism underlying decidualization remains poorly understood. Crystallin αB (CryAB), a small heat shock protein (sHSP), is up-regulated and phosphorylated in mouse decidua. In mouse primary endometrial stromal cells, CryAB is induced upon progesterone treatment via HIF1α. In addition, CryAB is strongly phosphorylated through the p38-MAPK pathway under stress or during in vitro decidualization. Knockdown of CryAB results in the increase of apoptosis of stromal cells and inhibits decidualization under oxidative or inflammatory stress. Our data indicate that CryAB protects decidualization against stress conditions.
authors.affiliation: School of Life Science, Xiamen University, Xiamen 361005, China; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Ru-Juan
authors.initials: RJ
authors.lastname: Zuo
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Yue-Chao
authors.initials: YC
authors.lastname: Zhao
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
authors.affiliation: School of Science, Shantou University, Shantou 515063, China.
authors.forename: Tong-Song
authors.initials: TS
authors.lastname: Wang
authors.affiliation: School of Science, Shantou University, Shantou 515063, China.
authors.forename: Bao-Cheng
authors.initials: BC
authors.lastname: Wang
authors.affiliation: School of Life Science, Xiamen University, Xiamen 361005, China; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: zmyang@scau.edu.cn.
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Yang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015687:Cell Hypoxia; D003656:Decidua / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism; D038203:alpha-Crystallin B Chain / Q000235:genetics / Q000378:metabolism*
chemical_list: D038203:alpha-Crystallin B Chain; D011374:Progesterone
keywords: CryAB; Decidualization; Stress