title: [Metabolic changes in abnormal savda patients with different types of tumor: a clinical observation].
abstract: OBJECTIVE
  To explore in vivo metabolic changes in abnormal savda patients with different types of tumor.
  
  
  METHODS
  A total of 142 abnormal savda patients with common cancer types were enrolled in this study, and 50 healthy volunteers were recruited as the control group. For each sample, the H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed. The free attenuation signal was computed subsection integral. Data obtained were analyzed by the Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA).
  
  
  RESULTS
  Compared with the control group, leucine, isoleucine, valine, histidine, phenylalanine, tyrosine, alanine, creatine, lactic acid, inositol, alpha-and beta-glucose, unsaturated lipids, very low density lipoprotein (VLDL) significantly decreased (P <0.05), while glycoprotein and carnitine significantly increased (P <0. 05) in the abnormal Savda group.
  
  
  CONCLUSIONS
  Abnormal savda patients with different types of tumor had similar metabonomics changes.
authors.forename: Yin
authors.initials: Y
authors.lastname: Chen
authors.forename: Mei-Zuo
authors.initials: MZ
authors.lastname: Zhong
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
authors.forename: Batur
authors.initials: B
authors.lastname: Mamtimin
authors.forename: Wan-Li
authors.initials: WL
authors.lastname: Deng
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Kamilijiang
authors.initials: K
authors.lastname: Mayila
mesh_terms: D016002:Discriminant Analysis; D006801:Humans; D016018:Least-Squares Analysis; D008055:Lipids / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D055442:Metabolome / Q000502:physiology*; D055432:Metabolomics; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D008055:Lipids