title: Simultaneous bilateral testicular metastases from renal clear cell carcinoma: A case report and review of the literature.
abstract: Metastasis from renal cell carcinoma (RCC) to the testis is rare. This case report presented an extremely rare case of simultaneous bilateral testicular metastases from RCC in a 65-year-old man who had experienced indolent scrotal enlargement over a period of several months. Scrotal ultrasonography showed 4.0- and 2.0-cm-sized masses in the left and right testes, respectively. Contrast-enhanced computed tomography identified multiple tumors in the kidneys, the pancreas and the left adrenal gland. Left orchiectomy and pathological examination were performed and indicated testicular metastasis from clear cell RCC. The patient underwent complete surgical resection of all residual lesions. Postoperative follow-up examination without adjuvant therapy identified no recurrence over 11 months. This study also reviewed existing literature and determined that retrograde venous spread from the primary kidney tumor to the testis may be an important pathway for testicular metastasis from RCC. In conclusion, RCC can result in testicular metastases not only unilaterally, but also bilaterally, as was observed in the present case.
authors.affiliation: Department of Urology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Moriyama
authors.affiliation: Department of Urology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Takeshita
authors.affiliation: Department of Pathology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Adachi
authors.affiliation: Department of Urology, Nishi-Ohmiya Hospital, Saitama City, Saitama 330-0856, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Arai
authors.affiliation: Department of Urology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Higuchi
authors.affiliation: Department of Pathology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Takuo
authors.initials: T
authors.lastname: Tokairin
authors.affiliation: Department of Urology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Chiba
authors.affiliation: Department of Surgery, Saitama Red Cross Hospital, Saitama City, Saitama 338-8553, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Nakagawa
authors.affiliation: Department of Urology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Noro
keywords: metastasis; renal cell carcinoma; testicular neoplasm