title: Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature.
abstract: Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.
authors.affiliation: Department of Head and Neck Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Wellington
authors.initials: W
authors.lastname: Alves Filho
authors.affiliation: Department of Head and Neck Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Renata Regina da Graça Lorencetti
authors.initials: RR
authors.lastname: Mahmoud
authors.affiliation: Department of Head and Neck Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Daniel Marin
authors.initials: DM
authors.lastname: Ramos
authors.affiliation: Department of Head and Neck Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Vergilius José Furtado de
authors.initials: VJ
authors.lastname: Araujo-Filho
authors.affiliation: Department of Pathology, FMUSP, Sao Paulo, SP, Brazil.
authors.forename: Patricia Picciarelli de
authors.initials: PP
authors.lastname: Lima
authors.affiliation: Department of Head and Neck Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Claudio Roberto
authors.initials: CR
authors.lastname: Cernea
authors.affiliation: Department of Head and Neck Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Lenine Garcia
authors.initials: LG
authors.lastname: Brandão
mesh_terms: D017668:Age of Onset; D018952:Antigens, CD34 / Q000032:analysis; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008875:Middle Aged; D035583:Rare Diseases / Q000473:pathology* / Q000601:surgery; D054364:Solitary Fibrous Tumors / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D018952:Antigens, CD34