title: A survey on computational approaches to identifying disease biomarkers based on molecular networks.
abstract: The disease biomarkers can help make accurate diagnosis and therefore give appropriate interventions. In the past years, the accumulation of various kinds of 'omics' data, e.g. genomics and transcriptomics, makes it possible to identify disease biomarkers in a more efficient way. In particular, the molecular networks that describe the functional relationships among molecules enable the identification of disease biomarkers from a systematic perspective. In this paper, we surveyed the recent progress on the computational approaches that have been developed to identify disease biomarkers based on molecular networks. In addition, we introduced the popular resources about human interactomes and regulatomes as well as human diseasomes, whose availability makes it possible to predict the disease biomarkers with the utility of networks.
authors.affiliation: School of Electronics and Information Engineering, Tongji University, 4800 Caoan Highway, Shanghai 201804, China; School of Software, Xidian University, No. 2 South Taibai Road, Xi׳an 710071, China.
authors.forename: Guimin
authors.initials: G
authors.lastname: Qin
authors.affiliation: School of Electronics and Information Engineering, Tongji University, 4800 Caoan Highway, Shanghai 201804, China. Electronic address: xm_zhao@tongji.edu.cn.
authors.forename: Xing-Ming
authors.initials: XM
authors.lastname: Zhao
mesh_terms: D000465:Algorithms; D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D030562:Databases, Protein; D005189:False Positive Reactions; D005786:Gene Expression Regulation; D023281:Genomics; D006801:Humans; D009154:Mutation; D010641:Phenotype; D014176:Protein Biosynthesis; D025941:Protein Interaction Mapping; D012984:Software; D059467:Transcriptome
chemical_list: D015415:Biomarkers
keywords: Diseasome; Dysfunctional module; Dysregulated pathway; Interactome; Regulatome