title: [Pediatric HIV infections in developed countries: current situation and future challenges].
abstract: In 2013, approximately 1500 HIV-infected children are followed in France. Antiretroviral therapy (ART) has greatly improved the survival of these children, whose long-term clinical outcomes are encouraging in high-resources countries. However, paediatricians continue to face difficulties for these children: missed opportunities for early HIV testing (especially in immigrant children born in Sub-Saharan African countries), high rates of virological failure in ART-experienced children, lack of studies evaluating the long-term toxicity of ART in perinatally-HIV-infected patients. Future challenges will imply to study to what extent very early ART in infants may alter the establishment of HIV infection and improve the long-term immunological and virological outcome of these children.
authors.affiliation: Unité d'immunologie, hématologie et rhumatologie pédiatriques, Assistance publique-hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France - EA 3620, université Paris Descartes, Sorbonne Paris Cité, Paris, France - Laboratoire de microbiologie, Assistance publique-hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Frange
authors.affiliation: Unité d'immunologie, hématologie et rhumatologie pédiatriques, Assistance publique-hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France - EA 3620, université Paris Descartes, Sorbonne Paris Cité, Paris, France - Institut IMAGINE, université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.affiliation: EA 3620, université Paris Descartes, Sorbonne Paris Cité, Paris, France - Laboratoire de microbiologie, Assistance publique-hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Chaix
mesh_terms: D017668:Age of Onset; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002648:Child; D019049:Developed Countries / Q000706:statistics & numerical data*; D055808:Drug Discovery / Q000639:trends; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D011358:Product Surveillance, Postmarketing
chemical_list: D044966:Anti-Retroviral Agents