title: Review of preclinical studies on treatment of mucositis and associated pain.
abstract: Oral mucositis is a significant problem in cancer patients treated with radiation or chemotherapy, often hindering definitive cancer treatment. For patients with oral mucositis, pain is the most distressing symptom, leading to loss of orofacial function and poor quality of life. While oral mucositis has been well-described, its pathophysiology is poorly understood. Oral health professionals treating patients with mucositis have almost no effective therapies to treat or prevent oral mucositis. The purpose of this review is to (1) describe the current preclinical models of oral mucositis and their contribution to the understanding of mucositis pathophysiology, (2) explore preclinical studies on therapies targeting mucositis and discuss the clinical trials that have resulted from these preclinical studies, and (3) describe the proposed pathophysiology of oral mucositis pain and preclinical modeling of oral mucositis pain.
authors.affiliation: Bluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Oral and Maxillofacial Surgery, New York University, College of Dentistry, NY, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Viet
authors.affiliation: Bluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Periodontics, New York University, College of Dentistry, NY, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Corby
authors.affiliation: Bluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Akinwande
authors.affiliation: Bluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Oral and Maxillofacial Surgery, New York University, College of Dentistry, NY, USA bls322@nyu.edu.
authors.forename: B L
authors.initials: BL
authors.lastname: Schmidt
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy / Q000503:physiopathology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D013280:Stomatitis / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000700:Analgesics
keywords: cancer complications; cancer symptoms; mucositis models; mucositis treatment; oral pain; stomatitis