title: Global Burden of Severe Tooth Loss: A Systematic Review and Meta-analysis.
abstract: The goal of the Global Burden of Disease 2010 Study has been to systematically produce comparable estimates of the burden of 291 diseases and injuries and their associated 1,160 sequelae from 1990 to 2010. We aimed to report here internally consistent prevalence and incidence estimates of severe tooth loss for all countries, 20 age groups, and both sexes for 1990 and 2010. The systematic search of the literature yielded 5,618 unique citations. After titles and abstracts were screened, 5,285 citations were excluded as clearly not relevant to this systematic review, leaving 333 for full-text review; 265 publications were further excluded following the validity assessment. A total of 68 studies-including 285,746 individuals aged 12 yr or older in 26 countries-were included in the meta-analysis using modeling resources of the Global Burden of Disease 2010 Study. Between 1990 and 2010, the global age-standardized prevalence of edentate people decreased from 4.4% (95% uncertainty interval: 4.1%, 4.8%) to 2.4% (95% UI: 2.2%, 2.7%), and incidence rate decreased from 374 cases per 100,000 person-years (95% UI: 347, 406) to 205 cases (95% UI: 187, 226). No differences were found by sex in 2010. Prevalence increased gradually with age, showing a steep increase around the seventh decade of life that was associated with a peak in incidence at 65 years. Geographic differences in prevalence, incidence, and rate of improvement from 1990 to 2010 were stark. Our review of available quality literature on the epidemiology of tooth loss shows a significant decline in the prevalence and incidence of severe tooth loss between 1990 and 2010 at the global, regional, and country levels.
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA Department of Anesthesiology and Pain Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Kassebaum
authors.affiliation: Division of Population and Patient Health, King's College London, Dental Institute at Guy's, King's College, and St. Thomas' Hospitals, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Bernabé
authors.affiliation: Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Dahiya
authors.affiliation: Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Bhandari
authors.affiliation: Department of Anesthesiology and Pain Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
authors.forename: C J L
authors.initials: CJ
authors.lastname: Murray
authors.affiliation: Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK w.marcenes@qmul.ac.uk.
authors.forename: W
authors.initials: W
authors.lastname: Marcenes
mesh_terms: D000367:Age Factors; D017281:Cost of Illness; D014943:Global Health / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D009066:Mouth, Edentulous / Q000453:epidemiology; D015995:Prevalence; D016388:Tooth Loss / Q000453:epidemiology*
keywords: edentate; epidemiology; extracted teeth; global health; missing teeth; toothless