title: Novel developments in metabolic disorders of purine and pyrimidine metabolism and therapeutic applications of their analogs.
abstract: The biennial 15th symposium on Purine and Pyrimidine metabolism was held in Madrid, June 2013 (PP13). During the meeting, several novel developments on the diagnosis, pathophysiology, and treatment of several inborn errors of purine and pyrimidine metabolism were presented. These ranged from new drugs for gout to enzyme replacement therapies for mitochondrial diseases. A relatively novel aspect in this meeting was the interest in purine and pyrimidine metabolism in nonmammalian systems, such as parasites, mycoplasms, and bacteria. Development of novel analogs for parasite infections, cardiovascular diseases, inflammatory diseases, and cancer were also discussed.
authors.affiliation: a Divisions of Internal Medicine and Clinical Biochemistry, Unidad Metabólico-Vascular, Edificio de Consultas Externas, Planta SEMISÓTANO , Hospital Universitario "La Paz" , Paseo de la Castellana 261, 28046 Madrid , Spain.
authors.forename: Rosa J
authors.initials: RJ
authors.lastname: Torres
authors.forename: Godefridus J
authors.initials: GJ
authors.lastname: Peters
authors.forename: Juan G
authors.initials: JG
authors.lastname: Puig
mesh_terms: D001363:Awards and Prizes; D006801:Humans; D011686:Purine-Pyrimidine Metabolism, Inborn Errors / Q000188:drug therapy* / Q000378:metabolism*; D011687:Purines / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D011743:Pyrimidines / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D011687:Purines; D011743:Pyrimidines; C030986:pyrimidine; C030985:purine
keywords: Purines; antimetabolites; inborn errors; pyrimidines