title: [Searching for new antibiotics--inhibitors of bacterial chromosome replication].
abstract: The excessive and often unreasonable use of antibacterial drugs leads to rise of antibioticresistant strains. To overcome this problem, new antibiotics are searched and the new drug targets are investigated. The proteins involved in replication of bacterial chromosomes seem to be promising candidates for drug targets since they are involved in crucial life pathways and are structurally and/or functionally different from the eukaryotic homologues. Within last few years, a large number of newly developed methods allowed to search among thousands of molecules for the ones that specifically inhibit DNA synthesis in the prokaryotic cell. In this review, we present some of these methods.
authors.affiliation: Wydział Biotechnologii, Uniwersytet Wrocławski.
authors.forename: Damian
authors.initials: D
authors.lastname: Trojanowski
authors.affiliation: Wydział Biotechnologii, Uniwersytet Wrocławski.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Skut
authors.affiliation: Instytut Immunologii i Terapii Doświadczalnej PAN im. Ludwika Hirszfelda, we Wrocławiu.
authors.forename: Joanna
authors.initials: J
authors.lastname: Hołówka
authors.affiliation: Wydział Biotechnologii, Uniwersytet Wrocławski.
authors.forename: Marcin Jan
authors.initials: MJ
authors.lastname: Szafran
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002876:Chromosomes, Bacterial / Q000187:drug effects* / Q000235:genetics*; D004261:DNA Replication / Q000187:drug effects; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D008958:Models, Molecular
chemical_list: D000900:Anti-Bacterial Agents