title: The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes.
abstract: BACKGROUND
  To investigate the impact of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus (HBV) infection on perinatal outcomes.
  
  
  METHODS
  In the study, 200 pregnant women were divided into four groups, including 50 cases with ICP and HBV infection, 50 cases with ICP, 50 cases with HBV infection, and 50 healthy pregnancies. The delivery process and perinatal outcomes were analyzed among different groups.
  
  
  RESULTS
  When compared to the healthy pregnancy group, significantly increased rates of premature rupture of membranes, meconium-stained amniotic fluid, and cesarean section were observed in cases of ICP, HBV infection, or ICP patients with HBV (P<0.05). Specifically, the rates of HBV infection in the newborn, fetal distress, neonatal asphyxia, and birth defects in the newborn, and infant Apgar scores were higher in ICP pregnancies with HBV (56%, 48%, 16%, and 48%, respectively) than in the other groups (P<0.05).
  
  
  CONCLUSIONS
  ICP combined with HBV infection has a clear influence on perinatal infant outcomes.
authors.affiliation: Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People's Republic of China.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Ding
authors.affiliation: Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yu
keywords: Apgar scores; birth defects; cesarean section; fetal distress; meconium-stained amniotic fluid; neonatal asphyxia; premature rupture of membranes