title: Model system for targeted drug release triggered by immune-specific signals.
abstract: A new sense-and-act system was realized by integrating a biocatalytic/bioaffinity electrode responding to immune signals represented by an antibody and a polymer-modified electrode loaded with drug-mimicking species. The release of the drug-mimicking species was achieved specifically in response to a signal antibody, thus demonstrating for the first time an immune-induced drug-releasing process. The present approach promises new options for future applications in controlled drug release and personalized medicine.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, 13699-5810, USA.
authors.forename: Shay
authors.initials: S
authors.lastname: Mailloux
authors.forename: Nataliia
authors.initials: N
authors.lastname: Guz
authors.forename: Maria
authors.initials: M
authors.lastname: Gamella Carballo
authors.forename: José M
authors.initials: JM
authors.lastname: Pingarrón
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz