title: Rapid access to novel 1,2,3-triazolo-heterocyclic scaffolds via tandem Knoevenagel condensation/azide-alkyne 1,3-dipolar cycloaddition reaction in one pot.
abstract: An operationally simple, one-pot, two-step cascade method has been developed to afford biologically important fused 1,2,3-triazolo-heterocyclic scaffolds from 2-alkynyl aryl(heteroaryl) aldehydes and phenacyl azides. This unique atom economical transformation engages four reactive centers (aldehyde, alkyne, active methylene, and azide) under metal-free catalysis.
authors.affiliation: Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors.forename: Ram Awatar
authors.initials: RA
authors.lastname: Maurya
authors.forename: Praveen Reddy
authors.initials: PR
authors.lastname: Adiyala
authors.forename: D
authors.initials: D
authors.lastname: Chandrasekhar
authors.forename: Chada Narsimha
authors.initials: CN
authors.lastname: Reddy
authors.forename: Jeevak Sopanrao
authors.initials: JS
authors.lastname: Kapure
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000480:Alkynes; D001386:Azides; D006571:Heterocyclic Compounds; D014230:Triazoles
keywords: Knoevenagel condensation; azide−alkyne cycloaddition; isoquinoline; pyrazolo-pyridine; tandem reaction; triazole; β-carboline