title: Serum monocyte chemokine protein-1 levels before and after parathyroidectomy in patients with primary hyperparathyroidism.
abstract: OBJECTIVE
  To investigate the effects of parathyroidectomy on serum monocyte chemokine protein-1 (MCP-1) levels in patients with primary hyperparathyroidism (PHPT).
  
  
  METHODS
  Forty-three PHPT patients, age 56 ± 12 years, underwent minimally invasive parathyroidectomy. Serum samples were collected at 0 and 15 to 20 minutes after parathyroid adenoma removal. Serum samples were stored at -70°C until time of assay.
  
  
  RESULTS
  In 40 PHPT patients with a single adenoma, MCP-1 levels decreased from 342 ± 103 to 250 ± 77 pg/mL (P<.001) 15 to 20 minutes after parathyroid adenoma removal. MCP-1 levels were positively correlated with intact parathyroid hormone (PTH) levels (R = 0.47; P<.01). In 3 PHPT patients with double parathyroid adenoma, MCP-1 levels did not decrease after removal of the first adenoma but decreased 15 to 20 minutes after second adenoma removal.
  
  
  CONCLUSIONS
  Our results provide evidence that the decrease in serum intact PTH due to minimally invasive parathyroidectomy results in an immediate decrease in serum MCP-1 levels.
authors.affiliation: Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
authors.forename: Hemal
authors.initials: H
authors.lastname: Patel
authors.affiliation: Division of General Surgery, Departments of Medicine and Surgery, Rutgers Robert Wood Johnson Medical School.
authors.forename: Stanley
authors.initials: S
authors.lastname: Trooskin
authors.affiliation: Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
authors.forename: Sue
authors.initials: S
authors.lastname: Shapses
authors.affiliation: Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Wang