title: Transition-metal-assisted radical/radical cross-coupling: a new strategy to the oxidative C(sp3)-H/N-H cross-coupling.
abstract: A transition-metal-assisted oxidative C(sp(3))-H/N-H cross-coupling reaction of N-alkoxyamides with aliphatic hydrocarbons is described. During the reaction, nitrogen radicals were generated from the oxidation of N-alkoxyamides. Experiments and DFT calculations revealed that transition-metal catalyst could lower the reactivity of the generated nitrogen radical by the coordination of the transition metal, which allowed the selective radical/radical cross-coupling with the transient sp(3) carbon radical to construct C(sp(3))--N bonds. Various C(sp(3))-H bonds could be transformed into C(sp(3))-N bonds through this radical amidation strategy.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhou
authors.forename: Shan
authors.initials: S
authors.lastname: Tang
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Qi
authors.forename: Caitao
authors.initials: C
authors.lastname: Lin
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000577:Amides; D028561:Transition Elements; D009584:Nitrogen