title: Primary sources of pelvic serous cancer in patients with endometrial intraepithelial carcinoma.
abstract: Serous endometrial intraepithelial carcinoma is often associated with extrauterine disease. It is currently unclear where does the extrauterine disease come from. This study addressed this issue. A total of 135 samples from 21 serous endometrial intraepithelial carcinoma patients were studied. Cellular lineage relationships between intrauterine and extrauterine serous carcinomas were determined by TP53-mutation analysis and correlated to the clinicopathologic features. There were three conditions contributing the extrauterine disease: metastasis from serous endometrial intraepithelial carcinoma (n=10) showed identical TP53 mutation between intrauterine lesions and extrauterine disease, cases of adnexal origin (n=5) had discordant TP53 mutations, and the mixed cellular origin cases (n=6) with both identical and discordant mutation status. Patients with extrauterine disease from serous endometrial intraepithelial carcinoma metastasis typically had small tumor masses (<2 cm) in extrauterine sites and without finding of serous tubal intraepithelial carcinoma, while extrauterine disease with adnexal or tubal origin commonly had larger tumor masses in extrauterine sites including ovary and omentum and serous tubal intraepithelial carcinoma. The majority of extrauterine diseases associated with serous endometrial intraepithelial carcinoma are metastasized from the endometrium. Serous endometrial intraepithelial carcinoma is frequently associated with serous cancers of adnexal or tubal origin, indicating that endometrial and adnexal or tubal serous cancers may share similar etiologies. TP53-mutation analysis provides a strong linkage for cellular lineage analysis. Tumor size in extrauterine disease and presence of serous tubal intraepithelial carcinoma or not are useful clinicopathologic features to determine primary cancer site, which helps in clinical management.
authors.affiliation: 1] Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China [2] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Jia
authors.affiliation: 1] Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China [2] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: 1] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA [2] Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Henan, China.
authors.forename: Yiying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA.
authors.forename: Janiel M
authors.initials: JM
authors.lastname: Cragun
authors.affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China.
authors.forename: Beihua
authors.initials: B
authors.lastname: Kong
authors.affiliation: 1] Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China [2] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA [3] Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA [4] Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology*; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000473:pathology*; D004252:DNA Mutational Analysis; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology*; D005185:Fallopian Tube Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D061346:Laser Capture Microdissection; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53