title: Prevalence and predictors of concomitant low sexual desire/interest and new-onset erectile dysfunction - a picture from the everyday clinical practice.
abstract: Prevalence and risk factors of concomitant primary low sexual desire/interest (LSD/I) and subsequent new-onset erectile dysfunction (ED) in men have been only partially investigated. We looked at the sociodemographic and clinical predictors of the concomitant condition of primary LSD/I - defined as the reduction in the usual level of SD/I which precedes ED or another sexual dysfunction - and new-onset ED (LSD/I + ED) in a cohort of consecutive Caucasian-European patients seeking their first medical help for sexual dysfunction at a single outpatient clinic in the everyday clinical practice setting. Data from 439 sexually active patients were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients' LSD/I were evaluated according to the findings of a comprehensive sexual history. Moreover, patients completed the International Index of Erectile Function (IIEF). Descriptive statistics and logistic regression models tested the prevalence and predictors of LSD/I + ED as compared with ED only. Of the 439 men, LSD/I + ED was observed in 33 (4.2%) individuals. One of three men with LSD/I + ED was younger than 40 years. Patients complaining of LSD/I + ED or ED alone did not differ in terms of hormonal milieu. No significant differences emerged between groups in terms of sexual orientation, rates of stable sexual relationships, educational status, recreational habits and comorbid sexual dysfunctions. Patients with LSD/I + ED had significantly lower IIEF-sexual desire and IIEF-overall satisfaction scores than ED-only individuals (all p ≤ 0.003). At multivariable analysis younger age and severe CCI scores emerged as independent predictors of LSD/I + ED (all p ≤ 0.04). These findings showed that primary LSD/I is concomitant with new-onset ED in less than 5% of men seeking first medical help. Younger age and severe CCI emerged as independent predictors of LSD/I + ED. Patients with both conditions reported an impaired overall sexual satisfaction.
authors.affiliation: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Research Doctorate Program in Urology, Magna Graecia University, Catanzaro, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Salonia
authors.forename: M C
authors.initials: MC
authors.lastname: Clementi
authors.forename: E
authors.initials: E
authors.lastname: Ventimiglia
authors.forename: M
authors.initials: M
authors.lastname: Colicchia
authors.forename: P
authors.initials: P
authors.lastname: Capogrosso
authors.forename: F
authors.initials: F
authors.lastname: Castiglione
authors.forename: G
authors.initials: G
authors.lastname: Castagna
authors.forename: L
authors.initials: L
authors.lastname: Boeri
authors.forename: N
authors.initials: N
authors.lastname: Suardi
authors.forename: F
authors.initials: F
authors.lastname: Cantiello
authors.forename: R
authors.initials: R
authors.lastname: Damiano
authors.forename: F
authors.initials: F
authors.lastname: Montorsi
mesh_terms: D000367:Age Factors; D015331:Cohort Studies; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000453:epidemiology*; D006801:Humans; D007989:Libido; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012307:Risk Factors; D012725:Sexual Behavior / Q000523:psychology*; D020018:Sexual Dysfunctions, Psychological / Q000453:epidemiology*; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D044465:White People
chemical_list: D013739:Testosterone; D011388:Prolactin; D013972:Thyrotropin
keywords: International Index of Erectile Function; clinical practice; comorbidities; erectile dysfunction; health status; libido; sexual desire