title: Quality of life, body mass index, and physical activity among uterine cancer patients.
abstract: OBJECTIVE
  The purpose of this study was to assess the independent and joint effects of body mass index (BMI) and physical activity (PA) on overall quality of life (QoL) in survivors of uterine cancer.
  
  
  METHODS
  We conducted a survey among uterine cancer patients who received curative therapy at the University of Pennsylvania between 2006 and 2010. Surveys assessed the weight, height, PA (college alumnus survey), and QoL (Functional Assessment of Cancer Therapy-Gynecologic Oncology Group).
  
  
  RESULTS
  The response rate to the survey was 43%. Among 213 patients, the mean (SD) BMI was 31.1 (8.9) kg/m, and 48% reported greater than or equal to 150 min·wk of PA. Higher BMI was independently associated with poorer overall QoL (P = 0.050), including physical (P = 0.002) and functional well-being (P = 0.008). Higher min·wk of PA was not independently associated with any QoL outcome. However, among patients who engaged in greater than or equal to 150 min·wk of PA, the negative association between BMI and overall QoL was attenuated (P = 0.558), whereas among patients who engaged in less than 150 min·wk of PA, the negative association between BMI and overall QoL persisted (P = 0.025). Among patients who engaged in greater than or equal to 150 min·wk of PA, the negative association between BMI and physical and functional well-being was attenuated (P = 0.765 and P = 0.284), whereas among patients who engaged in less than 150 min·wk of PA, the negative association between BMI and physical and functional well-being persisted (P < 0.001 and P = 0.010), respectively.
  
  
  CONCLUSIONS
  Body mass index is associated with poorer QoL among uterine cancer patients. The findings from this cross-sectional study are consistent with the hypothesis that endometrial cancer survivors who are able to perform 150 min/wk of PA may be protected from the negative effects of BMI on QoL.
authors.affiliation: *University of Pennsylvania, Philadelphia PA; and †University of Medicine and Dentistry of New Jersey, New Brunswick, NJ.
authors.forename: Lilie L
authors.initials: LL
authors.lastname: Lin
authors.forename: Justin C
authors.initials: JC
authors.lastname: Brown
authors.forename: Saya
authors.initials: S
authors.lastname: Segal
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Schmitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002291:Carcinoma, Papillary / Q000523:psychology / Q000534:rehabilitation; D002296:Carcinosarcoma / Q000523:psychology / Q000534:rehabilitation; D003430:Cross-Sectional Studies; D018284:Cystadenocarcinoma, Serous / Q000523:psychology / Q000534:rehabilitation; D016889:Endometrial Neoplasms / Q000523:psychology / Q000534:rehabilitation*; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D009367:Neoplasm Staging; D011379:Prognosis; D011788:Quality of Life; D011795:Surveys and Questionnaires; D015996:Survival Rate; D017741:Survivors; D014594:Uterine Neoplasms / Q000523:psychology / Q000534:rehabilitation*