title: Clinical Value of 18F-FDG PET/CT in Detecting Adrenal Metastasis in Patients with Hepatocellular Carcinoma.
abstract: The purpose of this study was to evaluate the accuracy of (18)F-FDG PET/CT scans in detecting adrenal metastasis in liver transplant candidates with hepatocellular carcinoma (HCC). A total of 166 patients diagnosed with HCC received (18)F-FDG PET/CT imaging before liver transplantation. Of these patients, 5 patients (4 males, 1 female; median age: 51.2 y, range: 33-61 y) were found to have suspected adrenal metastases and were included in this study. Two cases (Cases 1 and 5) underwent an (18)F-FDG PET/CT scan at the initial stage, 3 cases (Cases 2-4) underwent an (18)F-FDG PET/CT scan for restaging, and one case (Case 5) underwent a second (18)F-FDG PET/CT scan for evaluating treatment response. Among the 8 lesions, there was one false-negative metastatic lesion (Lesion 4, Case 3) and one false-positive adrenal gland lesion (Lesion 7, Case 5) when compared with either histopathologic reports or established clinical and imaging follow-up results. In general, (18)F-FDG PET/CT scans have limitations that make it difficult to distinguish between malignant and benign lesions in adrenal glands that are based only on quantitative values measured using the (18)F-FDG PET/CT scan.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Yin Lin and Wan-Yu Lin contributed equally to this work.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Long-Bin
authors.initials: LB
authors.lastname: Jeng
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Shih-Chuan
authors.initials: SC
authors.lastname: Tsai
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan Yin Lin and Wan-Yu Lin contributed equally to this work.
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan d10040@mail.cmuh.org.tw.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000556:secondary; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18; D016174:Hepacivirus / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; Adrenal metastasis; Liver transplantation.