title: Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity.
abstract: Six new asterosaponins, leptasteriosides A-F (3-8), one new and one previously known asterogenins (1, 2) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of 1-8 were elucidated by extensive NMR and ESI-MS techniques. Compounds 2-8 showed slight or moderate cytotoxic activities against cancer cell lines RPMI-7951 and T-47D. The asterosaponins 3-5 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in soft agar clonogenic assay in nontoxic doses.
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
authors.forename: Timofey V
authors.initials: TV
authors.lastname: Malyarenko
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
authors.forename: Alla A
authors.initials: AA
authors.lastname: Kicha
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Ivanchina
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
authors.forename: Roman S
authors.initials: RS
authors.lastname: Popov
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
authors.forename: Olesya S
authors.initials: OS
authors.lastname: Vishchuk
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia. Electronic address: stonik@piboc.dvo.ru.
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012503:Saponins
keywords: Asterosaponins; Clonogenic assay; Cytotoxicity; Leptasterias ochotensis; Starfish