title: The effect of dietary omega-3 polyunsaturated fatty acids on plasma lipids and lipoproteins of C57BL/6 mice is age and sex specific.
abstract: There is clear evidence of the effects of sex and age on the prevalence of cardiovascular disease. We investigated the interactions of dietary omega (n)-3 polyunsaturated fatty acids (PUFA), sex, and age on plasma lipids and lipoproteins in the offspring of C57BL/6 mice exposed to high, medium, or low n-3 PUFA at weaning and 16 weeks postweaning. There was an increase in plasma triglycerides from weaning to 16 weeks in male and female offspring; however, the high n-3 PUFA group showed a reduction in triglycerides in both sexes at 16 weeks. High n-3 PUFA caused an increase in plasma LDL-cholesterol from weaning to 16 weeks in male offspring; however, the LDL particle size was significantly larger in the high n-3 PUFA group. Plasma from male mice showed higher cholesterol efflux compared to females; high n-3 PUFA increased cholesterol efflux. Thus the effects of n-3 PUFA are age and sex dependent.
authors.affiliation: Department of Biochemistry, Memorial University, St. John׳s, NL, Canada.
authors.forename: K A
authors.initials: KA
authors.lastname: Balogun
authors.affiliation: Department of Biochemistry, Memorial University, St. John׳s, NL, Canada.
authors.forename: R S
authors.initials: RS
authors.lastname: Randunu
authors.affiliation: Department of Biochemistry, Memorial University, St. John׳s, NL, Canada. Electronic address: skaur@mun.ca.
authors.forename: S K
authors.initials: SK
authors.lastname: Cheema
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001692:Biological Transport; D008078:Cholesterol, LDL / Q000097:blood*; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D005526:Food, Formulated; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008810:Mice, Inbred C57BL; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*; D014886:Weaning
chemical_list: D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D008074:Lipoproteins; D014280:Triglycerides
keywords: Age; Cholesterol efflux; Lipids and lipoproteins; Sex; n-3 PUFA