title: Valvular heart disease associated with long-term treatment by methysergide: a case report.
abstract: This case report concerns a woman treated continuously since at least 10 years by methysergide for cluster headache. The echocardiographic and histological features of the severe valve fibrosis presented by this patient are very similar to those described with 5 HT(2B) receptors agonistic drugs.
authors.affiliation: Service de Pharmacologie clinique, Centre régional de Pharmacovigilance de Picardie, Centre hospitalier universitaire Sud d'Amiens, Amiens, France - INSERM U 1088, Université de Picardie, Amiens, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Andréjak
authors.affiliation: Service de Cardiologie, Centre hospitalier universitaire Sud d'Amiens, Amiens, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Szymanski
authors.affiliation: GCS-Groupement des hôpitaux de l'Institut catholique de Lille/Faculté de médecine, Université Lille Nord de France, UC Lille, Lille, France.
authors.forename: Sylvestre
authors.initials: S
authors.lastname: Maréchaux
authors.affiliation: Service de Cardiologie, Centre hospitalier universitaire Sud d'Amiens, Amiens, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Arnalsteen
authors.affiliation: Service de Pharmacologie clinique, Centre régional de Pharmacovigilance de Picardie, Centre hospitalier universitaire Sud d'Amiens, Amiens, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gras
authors.affiliation: Service de Chirurgie cardiaque, Centre hospitalier universitaire Sud d'Amiens, Amiens, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Rémadi
authors.affiliation: INSERM U 1088, Université de Picardie, Amiens, France - Service de Cardiologie, Centre hospitalier universitaire Sud d'Amiens, Amiens, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tribouilloy
mesh_terms: D003027:Cluster Headache / Q000188:drug therapy; D005260:Female; D005355:Fibrosis; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008784:Methysergide / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D012702:Serotonin Antagonists; D008784:Methysergide