title: Appraisal of clinical practice guidelines for ischemic stroke management in Chinese medicine with appraisal of guidelines for research and evaluation instrument: A systematic review.
abstract: OBJECTIVE
  To systematically review the clinical practice guidelines (CPGs) for ischemic stroke in Chinese medicine (CM) with the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument.
  
  
  METHODS
  CM CPGs for ischemic stroke were searched in 5 online databases and hand-searches in CPGrelated handbooks published from January 1990 to December 2012. The CPGs were categorized into evidence based (EB) guideline, consensus based with no explicit consideration of evidence based (CB-EB) guideline and consensus based (CB) guideline according to the development method. Three reviewers independently appraised the CPGs based on AGREE II instrument, and compared the CPGs' recommendations on CM pattern classification and treatment.
  
  
  RESULTS
  Five CM CPGs for ischemic stroke were identified and included. Among them, one CPG was EB guideline, two were CB guidelines and two were CB-EB guidelines. The quality score of the EB guideline was higher than those of the CB-EB and CB guidelines. Five CM patterns in the CPGs were recommended in the EB CPG. The comprehensive protocol of integrative Chinese and Western medicine recommended in the EB CPG was mostly recommended for ischemic stroke in the CPGs. The recommendations varied based on the CM patterns.
  
  
  CONCLUSIONS
  The quality of EB CPG was higher than those of CB and CB-EB CPGs in CM for ischemic stroke and integrative approaches were included in CPGs as major interventions.
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Yuwen
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
authors.forename: Nan-nan
authors.initials: NN
authors.lastname: Shi
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China. xuejieh@126.com.
authors.forename: Xue-Jie
authors.initials: XJ
authors.lastname: Han
authors.affiliation: Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Jian-long
authors.initials: JL
authors.lastname: Xu
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
authors.forename: Da-sheng
authors.initials: DS
authors.lastname: Liu
authors.affiliation: Chinese Medicine Department, Hong Kong Hospital Authority, Beijing, Hong Kong SAR, China.
authors.forename: Bacon
authors.initials: B
authors.lastname: Ng
authors.affiliation: Chinese Medicine Department, Hong Kong Hospital Authority, Beijing, Hong Kong SAR, China.
authors.forename: Dora
authors.initials: D
authors.lastname: Tsui
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, SAR, China.
authors.forename: Li-dan
authors.initials: LD
authors.lastname: Zhong
authors.affiliation: Chinese Medicine Department, Hong Kong Hospital Authority, Beijing, Hong Kong SAR, China.
authors.forename: Eric
authors.initials: E
authors.lastname: Ziea
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, SAR, China.
authors.forename: Zhao-xiang
authors.initials: ZX
authors.lastname: Bian
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China. aipinglu@hkbu.edu.hk.|School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, SAR, China. aipinglu@hkbu.edu.hk.
authors.forename: Ai-ping
authors.initials: AP
authors.lastname: Lu
mesh_terms: D035843:Biomedical Research; D002545:Brain Ischemia / Q000150:complications* / Q000628:therapy; D006287:Health Planning Guidelines; D006801:Humans; D008516:Medicine, Chinese Traditional; D017410:Practice Guidelines as Topic; D020521:Stroke / Q000150:complications* / Q000628:therapy*
keywords: Appraisal of Guidelines for Research and Evaluation; clinical practice guideline; ischemic stroke; systematic review