title: Jaundice and hepatic enzyme induction during lamotrigine therapy in a bipolar II patient.
abstract: Lamotrigine is a novel mood stabiliser as well as an anti-epileptic drug that has already been used for the prevention of convulsions. Despite several known side effects, hepatic dysfunction related to the drug has not been widely reported. A few cases have been observed in neurological, especially paediatric patients, but not in psychiatric patients. We report a case of cholestatis which occurred 6 weeks after starting lamotrigine therapy and which resolved after discontinuation, during the acute phase of disease. To the best of our knowledge, this is the first case of lamotrigine associated with cholestasis reported in patients with bipolar disorder.
authors.affiliation: Psychiatry Department, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.forename: Haluk A
authors.initials: HA
authors.lastname: Savas
authors.forename: Esen
authors.initials: E
authors.lastname: Savas
authors.forename: Hasan
authors.initials: H
authors.lastname: Herken
authors.forename: Hamdi
authors.initials: H
authors.lastname: Tutkun
authors.forename: H Serdar
authors.initials: HS
authors.lastname: Gergerlioglu
keywords: Lamotrigine; bipolar II disorder; cholestasis