title: Antidepressant-like effects of the ethyl acetate soluble fraction of the root bark of Morus alba on the immobility behavior of rats in the forced swim test.
abstract: In this study, the antidepressant-like effects of Morus alba fractions in rats were investigated in the forced swim test (FST). Male Wistar rats (9-week-old) were administered orally the M. alba ethyl acetate (EtOAc 30 and 100 mg/kg) and M. alba n-butanol fractions (n-BuOH 30 and 100 mg/kg) every day for 7 consecutive days. On day 7, 1 h after the final administration of the fractions, the rats were exposed to the FST. M. alba EtOAc fraction at the dose of 100 mg/kg induced a decrease in immobility behavior (p < 0.01) with a concomitant increase in both climbing (p < 0.05) and swimming (p < 0.05) behaviors when compared with the control group, and M. alba EtOAc fraction at the dose of 100 mg/kg decreased the hypothalamic-pituitary-adrenal (HPA) axis response to the stress, as indicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippocampal and hypothalamic paraventricular nucleus (PVN) region. These findings demonstrated that M. alba EtOAc fraction have beneficial effects on depressive behaviors and restore both altered c-fos expression and HPA activity.
authors.affiliation: Food Resource Research Center, Korea Food Research Institute, Seongnam 463-746, Korea. neodw4015@kfri.re.kr.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Research Group of Food Functionality, Korea Food Research Institute, Seongnam 463-746, Korea. ytkim@kfri.re.kr.
authors.forename: Yun Tai
authors.initials: YT
authors.lastname: Kim
authors.affiliation: Graduate School of Biotechnology and Research Institute of Life Sciences & Resources, Kyung Hee University, Yongin 446-701, Korea. wlgo3411@hanmail.net.
authors.forename: Ji-Hae
authors.initials: JH
authors.lastname: Park
authors.affiliation: Graduate School of Biotechnology and Research Institute of Life Sciences & Resources, Kyung Hee University, Yongin 446-701, Korea. nibaek@khu.ac.kr.
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.affiliation: Food Resource Research Center, Korea Food Research Institute, Seongnam 463-746, Korea. imissu@kfri.re.kr.
authors.forename: Daeseok
authors.initials: D
authors.lastname: Han
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D031625:Morus; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D000085:Acetates; D000928:Antidepressive Agents; D010936:Plant Extracts; D016760:Proto-Oncogene Proteins c-fos; C007650:ethyl acetate