title: Evaluation of the role of dynamic contrast-enhanced MR imaging for patients with BI-RADS 3-4 microcalcifications.
abstract: OBJECTIVE
  The purpose of study was to prospectively evaluate the diagnostic performance of dynamic contrast-enhanced MR imaging in the differentiation of malignant lesions from benign ones in patients with BI-RADS 3-4 microcalcifications detected by mammography.
  
  
  METHODS
  93 women with 100 microcalcifications had undergone breast MRI from June 2010 to July 2013. Subsequently, 91 received open biopsy and 2 received stereotactic vacuum-assisted biopsy. All results were compared with histological findings. The PPV, NPV and area under curve (AUC) of the mammography and breast MRI were calculated.
  
  
  RESULTS
  There were 31 (31.0%) BI-RADS 3 microcalcifications and 69 (69.0%) BI-RADS 4. The PPV and NPV of mammography is 65.2% (45/69) and 90.3% (28/31). The PPV and NPV of breast MRI was 90.2% (46/51) and 95.9% (47/49). Among 31 BI-RADS 3 microcalcifications, the PPV and NPV of breast MRI was 100% (3/3) and 100% (28/28). Among 69 BI-RADS 4 microcalcifications, the PPV and NPV of breast MRI was 89.6% (43/48) and 90.5% (19/21). The AUC of mammography and breast MRI assessment were 0.738 (95% CI, 0.639-0.837) and 0.931 (95% CI, 0.874-0.988) (p<0.05).
  
  
  CONCLUSIONS
  Dynamic contrast-enhanced MR imaging of breast is able to be applied to predict the risk of malignance before follow-up for BI-RADS 3 microcalcifications and biopsy for BI-RADS 4 microcalcifications.
authors.affiliation: Division of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Yanni
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Division of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Jianjuan
authors.initials: J
authors.lastname: Lou
authors.affiliation: Division of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Division of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Division of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Dehang
authors.initials: D
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging