title: Clinical pathologies of breast cancer in the elderly and youths and their prognosis.
abstract: OBJECTIVE
  To explore the correlation between the clinical pathologies of breast cancer in the elderly and youths as well as their prognosis.
  
  
  METHODS
  Two hundred and eighty breast cancer patients were divided into a youth group (<60, n=120) and an elderly group (≥60, n=160) according to the age. Their routine clinical pathological indices and immune indices were observed and determined, and the prognosis was observed after effective treatment.
  
  
  RESULTS
  The positive expression rates of p63, CK5/6, CK14 and CK17 in the elderly group were significantly higher than those of the youth group (P<0.05). The tumor-free survival rate of the youth group (95.8%) was significantly higher than that of the elderly group (84.4%) (P<0.05). Multivariate Logistic regression analysis showed that the positive expressions of p63 and estrogen receptor, age, and postoperative chemotherapy were the independent risk factors of tumor-free survival rate (P<0.05).
  
  
  CONCLUSIONS
  The immunohistochemical typing characteristics of the elderly and youths were different, and the prognosis of young patients was better, being correlated with the typing.
authors.affiliation: Hong Ji, Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.affiliation: Ning Ai, Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ai
authors.affiliation: Qinghuai Li, Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
authors.forename: Qinghuai
authors.initials: Q
authors.lastname: Li
authors.affiliation: Kaili Zhang, Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
authors.forename: Kaili
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Wang Di, Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
authors.forename: Wang
authors.initials: W
authors.lastname: Di
keywords: Age; Breast cancer; Immunohistochemistry; Pathological characteristics; Prognosis