title: Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals.
abstract: The IL28B genotype has been found to have a strong influence on spontaneous clearance of acute HCV both in HCV mono- and HIV/ the HCV co-infected patients. Spontaneous clearance of chronic HCV without HCV treatment is rare. Here, we report on three chronic HCV cases co-infected with HIV with spontaneous clearance of their HCV infection, all with the IL28B CC genotype. These cases were derived from a surveillance of the total HIV/HCV co-infected cohort in Sweden (n =4 66). The estimated frequency of spontaneous clearance of chronic HCV infection in our cohort was calculated to be 0.6-4.7%. Our cases lend some support to the initiation of ART prior to HCV treatment in HIV/HCV co-infected patients. Furthermore, HCV-RNA testing should be recommended immediately before initiation of HCV treatment, to find the subset of HIV/HCV co-infected patients with IL28B CC that may have cleared their chronic infection spontaneously.
authors.affiliation: Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Jenny
authors.initials: J
authors.lastname: Stenkvist
authors.affiliation: Division of Virology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jessica
authors.initials: J
authors.lastname: Nyström
authors.affiliation: Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Karolin
authors.initials: K
authors.lastname: Falconer
authors.affiliation: Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Division of Virology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Sönnerborg
authors.affiliation: Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address: ola.weiland@ki.se.
authors.forename: Ola
authors.initials: O
authors.lastname: Weiland
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count / Q000379:methods; D060085:Coinfection; D005260:Female; D056726:Genetic Association Studies; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012367:RNA, Viral / Q000097:blood*; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012698:Serologic Tests / Q000379:methods; D013548:Sweden; D019562:Viral Load / Q000379:methods; D000095022:Interferon Lambda
chemical_list: D044966:Anti-Retroviral Agents; D007372:Interferons; D007378:Interleukins; D012367:RNA, Viral; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
keywords: HCV; HIV; HIV/HCV co-infection; IL28B