title: The role of type I interferons in intestinal infection, homeostasis, and inflammation.
abstract: Type I interferons are a widely expressed family of effector cytokines that promote innate antiviral and antibacterial immunity. Paradoxically, they can also suppress immune responses by driving production of anti-inflammatory cytokines, and dysregulation of these cytokines can contribute to host-mediated immunopathology and disease progression. Recent studies describe their anti-inflammatory role in intestinal inflammation and the locus containing IFNAR, a heterodimeric receptor for the type I interferons has been identified as a susceptibility region for human inflammatory bowel disease. This review focuses on the role of type I IFNs in the intestine in health and disease and their emerging role as immune modulators. Clear understanding of type I IFN-mediated immune responses may provide avenues for fine-tuning existing IFN treatment for infection and intestinal inflammation.
authors.affiliation: Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Hyeseon
authors.initials: H
authors.lastname: Cho
authors.forename: Brian L
authors.initials: BL
authors.lastname: Kelsall
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D004195:Disease Models, Animal; D006706:Homeostasis; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology / Q000821:virology; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000378:metabolism; D007370:Interferon Type I / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000276:immunology* / Q000382:microbiology / Q000473:pathology / Q000821:virology; D051379:Mice; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000821:virology
chemical_list: D007370:Interferon Type I
keywords: enteric microbial infection; intestinal inflammation; type I interferons