title: A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
abstract: A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Jia
authors.initials: J
authors.lastname: Zheng
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Li
mesh_terms: D000578:Amidines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004126:Dimethylformamide / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000578:Amidines; D007202:Indicators and Reagents; D014227:Triazines; D003300:Copper; D004126:Dimethylformamide