title: Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes.
abstract: Axially chiral biaryls were synthesized by an isoquinoline or 2-pyridine-directed Rh(III)-catalyzed dual C-H cleavage and coupling with internal alkynes in good to excellent yields. Oxidation of isoquinoline derivatives with m-CPBA furnished their corresponding N-oxides, which could be utilized as Lewis base catalysts in asymmetric reactions.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China. slyou@sioc.ac.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D002723:Chlorobenzoates / Q000737:chemistry; D003500:Cyclization; D007546:Isoquinolines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D002723:Chlorobenzoates; D007546:Isoquinolines; D016877:Oxidants; D010087:Oxides; D011725:Pyridines; D012238:Rhodium; C000433:3-chloroperbenzoic acid; C039109:isoquinoline; C023666:pyridine