title: Peroxidasins: novel players in tissue genesis.
abstract: Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.
authors.affiliation: Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
authors.forename: Zalán
authors.initials: Z
authors.lastname: Péterfi
authors.affiliation: Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary; "Lendület" Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary. Electronic address: geiszt.miklos@med.semmelweis-univ.hu.
authors.forename: Miklós
authors.initials: M
authors.lastname: Geiszt
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism*; D024141:Collagen Type IV / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D009195:Peroxidase / Q000378:metabolism*; D013457:Sulfur Compounds / Q000737:chemistry; D000097423:Peroxidasin
chemical_list: D024141:Collagen Type IV; D003432:Cross-Linking Reagents; D016326:Extracellular Matrix Proteins; D009195:Peroxidase; D013457:Sulfur Compounds; D000097423:Peroxidasin
keywords: ROS; collagen IV; extracellular matrix; peroxidase; peroxidasin; sulfilimine