title: Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China.
abstract: Breast cancer in young women is typically with higher proportion of adverse pathological features. Breast cancer with BRCA1 mutation is often early-onset, and is usually associated with triple negative phenotpe. In this study, we aim to analyze the clinicopathological characteristics and prognosis in young breast cancer patients (≤35 years old) comparing to non-young patients (>35 years old). A total of 1913 cases of primary breast carcinoma with stage I-III were enrolled, with 283 cases diagnosed as young patients. No significant difference was observed in tumor size, TNM staging, lymph node metastasis, ER, HER-2 or histological grade between young and non-young patients. Multivariate analysis demonstrated that age was an independent prognostic factor for overall survival (OS). In 70 samples of young patients available, BRCA1 was immunohistochemically positive 85.7% in cytoplasm and 41.4% in nuclear. BRCA1 nuclear expression is not significantly associated with clinicopathological characteristics in young breast cancer patients.
authors.affiliation: 1] The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China [2] [3].
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Wei
authors.affiliation: 1] The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China [2].
authors.forename: Wen-He
authors.initials: WH
authors.lastname: Huang
authors.affiliation: Department of Breast Medical Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
authors.forename: Cai-Wen
authors.initials: CW
authors.lastname: Du
authors.affiliation: The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
authors.forename: Si-Qi
authors.initials: SQ
authors.lastname: Qiu
authors.affiliation: Cancer Research Center, Shantou University Medical College, Shantou 515041, China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Wei
authors.affiliation: Cancer Research Center, Shantou University Medical College, Shantou 515041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1] The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China [2] Cancer Research Center, Shantou University Medical College, Shantou 515041, China.
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D019313:BRCA1 Protein / Q000378:metabolism*; D001943:Breast Neoplasms / Q000208:ethnology / Q000378:metabolism* / Q000473:pathology*; D002467:Cell Nucleus / Q000378:metabolism*; D002681:China; D003593:Cytoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen