title: Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma.
abstract: OBJECTIVE
  Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma.
  
  
  METHODS
  Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively.
  
  
  RESULTS
  In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036).
  
  
  CONCLUSIONS
  15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Kang
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Sang Hyuk
authors.initials: SH
authors.lastname: Seo
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Shin
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Min Sung
authors.initials: MS
authors.lastname: An
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Tae Kwun
authors.initials: TK
authors.lastname: Ha
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Ki Beom
authors.initials: KB
authors.lastname: Bae
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Choi
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Oh
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Mi Seon
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Surgery, Inje University College of Medicine, Busan, Korea.
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Kim
keywords: 15-Hydroxyprostaglandin dehydrogenase; Differentiation; Gastric neoplasms; Staging