title: A chart review based comparative study of retention rates for two dispensing regimens for buprenorphine for subjects with opioid dependence at a tertiary care substance use disorder treatment center.
abstract: OBJECTIVE
  The current study aimed at comparison of retention rates for daily dispensing (DD) and alternate-day dispensing (AD) regimens for buprenorphine over a 1-year period at a tertiary care treatment center for management of substance use disorders. Additionally, it aimed at comparison of prescription refill proportions for these two buprenorphine dispensing regimens over a 1-year period.
  
  
  METHODS
  The study was conducted at a tertiary level substance use disorder treatment center.
  
  
  METHODS
  Case records of patients satisfying the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria for opioid dependence syndrome were included in the study.
  
  
  METHODS
  Retention rates and prescription refill proportions were compared for the two buprenorphine dispensing regimens for different time intervals over a 52-week period.
  
  
  RESULTS
  Fifty-two subjects (45.61 percent) were started on DD regimen and 62 (54.38 percent) were put on AD regimen of buprenorphine. All subjects were opioid dependent. The two groups did not differ for prescription refill proportions as well as retention rates for any of the time intervals studied.
  
  
  CONCLUSIONS
  The findings of the current study support feasibility and acceptance of alternate-day dosing strategy for buprenorphine dispensing for patients with opioid dependence.
authors.affiliation: Assistant Professor of Psychiatry, Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Yatan Pal Singh
authors.initials: YP
authors.lastname: Balhara
mesh_terms: D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D063128:Tertiary Health Care
chemical_list: D009292:Narcotic Antagonists; D002047:Buprenorphine