title: Effect of type 2 diabetes mellitus on pulmonary function.
abstract: BACKGROUND
  Type 2 diabetes mellitus (T2DM) is a metabolic disease with debilitating effects on multiple organs. The alveolar-capillary network in the lung is a large microvascular unit which may be affected by T2DM-associated microangiopathy.
  
  
  METHODS
  This retrospective study investigated whether type 2 diabetes mellitus (T2DM) affected pulmonary function. Of the 584 patients enrolled in the study, 292 had T2DM and 292 did not. Forced expiratory volume in one second (FEV₁), forced vital capacity (FVC), maximum voluntary ventilation (MVV) and total lung capacity (TLC) are values as percent of predicted, as well as FEV₁/FVC ratio which were values measured.
  
  
  RESULTS
  FEV₁, FVC, FEV₁/FVC ratio, MVV, and TLC were significantly lower in T2DM than in non-T2DM (P-values < 0.010). Multiple linear regression analysis found that for the entire study population fasting plasma glucose levels was negatively associated with FEV₁, FVC, FEV₁/FVC ratio and maximum voluntary ventilation (P-values < 0.030). Patients with T2DM were negatively associated with total lung capacity (P-values = 0.025). Multiple linear regression analysis found for patients with T2DM that fasting plasma glucose was negatively associated with FEV₁, FVC, FEV₁/FVC ratio and maximum voluntary ventilation (P-values < 0.020). In T2DM patient, height was negatively correlated with FEV₁ and FVC (all P-values < 0.020), triglycerides were negatively correlated with FEV₁/FVC ratio (P-values = 0.048), and creatinine was negatively correlated with total lung capacity (P-values = 0.017).
  
  
  CONCLUSIONS
  In summary, T2DM is associated with impaired pulmonary function consistent with obstructive ventilation pattern and fasting plasma glucose is an independent risk factor of reduced pulmonary function.
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Gong
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China.
authors.forename: G
authors.initials: G
authors.lastname: Chen
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000503:physiopathology*; D012129:Respiratory Function Tests
chemical_list: D001786:Blood Glucose