title: [Molecular epidemiological characteristics of HIV-1 strains isolated from newly diagnosed MSM subjects (2006-2010) in Beijing, China].
abstract: This study aims to analyze the molecular epidemiological characteristics of HIV-1 strains prevailing among men who have sex with men (MSM) in Beijing, China. The pol gene fragments from 250 newly diagnosed HIV-1-infected MSM individuals during 2006-2010 in Beijing were amplified by RT-nested PCR, sequenced, and phylogenetically analyzed. HIV-1 pol gene from 189 individuals were amplified and analyzed; 81 (42. 9%), 3 (1. 6%), 2 (1.0%), 88 (46. 6%), and 15 (7.9%) individuals were infected with HIV-1 subtypes B, B', C, CRF01_AE, and CRF07_BC, respectively. The subtypes B and CRF01_AE could both be grouped into two clusters, and CRFO7_BC strains shared high homology and were presumed to originate from a common ancestor. The HIV-1 circulating in MSM in Beijing had a lower genetic diversity than in heterosexuals. The HIV-1 epidemic (2006-2010) in MSM in Beijing was actually a rapid spread of HIV-1 CRF01 AE and B, or rather native strains of the two viruses.
authors.forename: Jing-Rong
authors.initials: JR
authors.lastname: Ye
authors.forename: Wan-Chun
authors.initials: WC
authors.lastname: Zang
authors.forename: Xue-Li
authors.initials: XL
authors.lastname: Su
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Lu
authors.forename: Ming-Qiang
authors.initials: MQ
authors.lastname: Hao
authors.forename: Ruo-Lei
authors.initials: RL
authors.lastname: Xin
authors.forename: Guo-Min
authors.initials: GM
authors.lastname: Chen
authors.forename: Xiong
authors.initials: X
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D058872:Epidemics; D014644:Genetic Variation; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D055815:Young Adult