title: Progress and prospects for engineered T cell therapies.
abstract: Proof-of-concept studies have demonstrated the therapeutic potential of engineered T cells. Transfer of recombinant antigen-specific T cell receptors (TCR) and chimaeric antigen receptors (CARs) against tumour and viral antigens are under investigation by multiple approaches, including viral- and nonviral-mediated gene transfer into both autologous and allogeneic T cell populations. There have been notable successes recently using viral vector-mediated transfer of CARs specific for B cell antigens, but also reports of anticipated and unanticipated complications in these and other studies. We review progress in this promising area of cellular therapy, and consider developments in antigen receptor therapies including the application of emerging gene-editing technologies.
authors.affiliation: Molecular & Cellular Immunology, Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital Trust, London, UK.
authors.forename: Waseem
authors.initials: W
authors.lastname: Qasim
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Thrasher
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics; D064987:Cell- and Tissue-Based Therapy / Q000639:trends*; D002986:Clinical Trials as Topic; D005544:Forecasting; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy / Q000639:trends*; D005822:Genetic Vectors / Q000235:genetics; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000502:physiology* / Q000637:transplantation; D014162:Transfection / Q000639:trends
chemical_list: D000951:Antigens, Neoplasm; D011948:Receptors, Antigen, T-Cell
keywords: T cells; gene therapy; transplantation