title: Make your own cigarettes: toxicant exposure, smoking topography, and subjective effects.
abstract: BACKGROUND
  Despite considerable use of make your own (MYO) cigarettes worldwide and increasing use in the United States, relatively little is known about how these cigarettes are smoked and the resultant toxicant exposure.
  
  
  METHODS
  In a laboratory study, we compared two types of MYO cigarettes-roll your own (RYO) and personal machine made (PMM)-with factory-made (FM) cigarettes in three groups of smokers who exclusively used RYO (n = 34), PMM (n = 23), or FM (n = 20). Within each group, cigarettes were smoked in three conditions: (i) after confirmed overnight tobacco abstinence; (ii) in an intense smoking paradigm; and (iii) without restrictions. All cigarettes were smoked ad lib through a smoking topography unit.
  
  
  RESULTS
  Plasma nicotine significantly increased after cigarettes in all conditions except PMM in the intense smoking paradigm. Puff volume, puff duration, total puff volume, and puff velocity did not differ between cigarette types but the puffs per cigarette and time to smoke were significantly smaller for RYO compared with PMM and FM. Regardless of the cigarette, participants consumed the first three puffs more vigorously than the last three puffs.
  
  
  CONCLUSIONS
  Despite the belief of many of their consumers, smoking MYO cigarettes is not a safe alternative to FM cigarettes. Like FM, MYO cigarettes expose their users to harmful constituents of tobacco smoke. Despite differences in size and design their puffing profiles are remarkably similar.
  
  
  CONCLUSIONS
  These data are relevant to health and regulatory considerations on the MYO cigarettes.
authors.affiliation: Battelle Memorial Institute, Human Exposure Assessment Laboratory (HEAL), Baltimore, Maryland. koszowskib@battelle.org.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Koszowski
authors.affiliation: Battelle Memorial Institute, Human Exposure Assessment Laboratory (HEAL), Baltimore, Maryland.
authors.forename: Zachary R
authors.initials: ZR
authors.lastname: Rosenberry
authors.affiliation: Battelle Memorial Institute, Human Exposure Assessment Laboratory (HEAL), Baltimore, Maryland.
authors.forename: Lauren C
authors.initials: LC
authors.lastname: Viray
authors.affiliation: Battelle Memorial Institute, Human Exposure Assessment Laboratory (HEAL), Baltimore, Maryland.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Potts
authors.affiliation: Battelle Memorial Institute, Human Exposure Assessment Laboratory (HEAL), Baltimore, Maryland.
authors.forename: Wallace B
authors.initials: WB
authors.lastname: Pickworth
mesh_terms: D000328:Adult; D015142:Baltimore; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000097:blood; D012907:Smoking / Q000009:adverse effects* / Q000097:blood / Q000523:psychology; D062789:Tobacco Products / Q000032:analysis* / Q000506:poisoning*; D014029:Tobacco Use Disorder / Q000097:blood / Q000175:diagnosis / Q000209:etiology*
chemical_list: D009538:Nicotine