title: Effects of thyroid dysfunction on the severity of coronary artery lesions and its prognosis.
abstract: BACKGROUND
  Abnormal thyroid hormone metabolism influences the occurrence and progress of coronary heart disease (CHD). The aim of the present study was to analyze the severity of coronary artery lesions and the prognosis of thyroid dysfunction patients admitted for coronary angiography (CAG).
  
  
  METHODS
  From July 2011 to July 2012, 605 consecutive patients with suspected coronary heart disease admitted for CAG were selected. The patients were divided into three groups, based on their thyroid function prior to CAG: euthyroid group (n=455 patients), low T3 syndrome group (n=96 patients), and hypothyroidism group (n=54 patients). All patients underwent CAG. Then the severity of coronary artery lesions was assessed by Gensini scores. All patients were followed up for major adverse cardiac events.
  
  
  RESULTS
  The prevalence of CHD in low T3 syndrome group and hypothyroidism group was significantly higher than that in the euthyroid group (p<0.001 and p=0.004, respectively). Moreover, the severity of coronary artery lesions in low T3 syndrome group and hypothyroidism group was significantly greater than that in the euthyroid group (all p<0.001). Multinomial logistic regression analysis demonstrated that low T3 syndrome was an independent risk factor of coronary artery moderate [odds ratio (OR)=4.268, 95% CI: 3.294-7.450, p=0.016] and severe (OR=4.294, 95% CI: 2.259-9.703, p<0.001) lesions. The mean duration of follow-up was 15.3±3.8 months; patients with thyroid dysfunction had a significantly worse prognosis as compared to those in the euthyroid group for the composite end-point (p<0.01). Moreover, the incidence of the composite end-point (all-cause death, non-fatal myocardial infarction, and coronary revascularization) was significantly higher in low T3 syndrome group and hypothyroidism group compared with that of in the euthyroid group (all p<0.001).
  
  
  CONCLUSIONS
  The patients with hypothyroidism and low T3 syndrome had a high prevalence of CHD, increased severity of coronary artery lesions and poor prognosis.
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Min-fu
authors.initials: MF
authors.lastname: Bai
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China; Henan Institute of Cardiovascular Epidemiology, Zhengzhou, China. Electronic address: gaocy6802@163.com.
authors.forename: Chuan-yu
authors.initials: CY
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Henan Medical College for Staff and Workers, Xinzheng, China. Electronic address: yangchaokuan123@sina.cn.
authors.forename: Chao-kuan
authors.initials: CK
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Xian-pei
authors.initials: XP
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Da-tun
authors.initials: DT
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China; Henan Institute of Cardiovascular Epidemiology, Zhengzhou, China.
authors.forename: You
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Pei-yuan
authors.initials: PY
authors.lastname: Hao
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Mu-wei
authors.initials: MW
authors.lastname: Li
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D013959:Thyroid Diseases / Q000150:complications*
keywords: Coronary angiography; Coronary heart disease; Hypothyroidism; Low T3 syndrome