title: [Carotid intima-media thickness and estimated glomerular filtration rate in hypertensive patients].
abstract: OBJECTIVE
  To determine the association between carotid atherosclerosis and renal function in hypertensive patients.
  
  
  METHODS
  A total of 2 809 hypertensive patients aged (56.59±10.79) years were enrolled. Carotid intima-media thickness (cIMT) was derived via B-mode ultrasonography and chronic kidney disease (CKD) was evaluated by the estimated glomerular filtration rate (eGFR) with Cockcroft- Gault method. The patients were divided into 3 groups: a normal group, a thick group, and a plaque group according to the results of carotid ultrasonography.
  
  
  RESULTS
  The eGFR of the normal group was (111.09±25.61) mL/(min.1.73m(2)), that of the thick group and the plaque group was (94.45±27.14) mL/(min.1.73m(2)) and (85.98±26.92) mL/ (min.1.73m(2)). Binary logistic analysis showed that age (OR=3.590), smoking status (OR=1.543), systolic blood pressure (OR=1.018), diastolic blood pressure (OR=0.977), fasting plasma glucose (OR=1.132), triglyceride (OR=0.873) and eGFR (OR=0.986) were significantly correlated with cIMT. Subgroup analyses on different genders showed that eGFR was a significant independent risk factor in men (OR=0.991) but not in women.
  
  
  CONCLUSIONS
  The thicker the cIMT, the lower the eGFR in hypertensive patients. With the development of cIMT, eGFR gradually decreases and contributes to the occurrence and development of early-stage atherosclerosis in hypertensive patients.
authors.affiliation: Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Pingting
authors.initials: P
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Chunyan
authors.initials: C
authors.lastname: Weng
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Cao
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000368:Aged; D050197:Atherosclerosis; D001794:Blood Pressure; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases; D059168:Carotid Intima-Media Thickness; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic; D012307:Risk Factors; D012907:Smoking