title: Effects of intensive insulin therapy combined with low molecular weight heparin anticoagulant therapy on severe pancreatitis.
abstract: The current study explored the effects of intensive insulin therapy (IIT) combined with low molecular weight heparin (LMWH) anticoagulant therapy on severe acute pancreatitis (SAP). A total of 134 patients with SAP that received treatment between June 2008 and June 2012 were divided randomly into groups A (control; n=33), B (IIT; n=33), C (LMWH; n=34) and D (IIT + LMWH; n=34). Group A were treated routinely. Group B received continuous pumped insulin, as well as the routine treatment, to maintain the blood sugar level between 4.4 and 6.1 mmol/l. Group C received a subcutaneous injection of LMWH every 12 h in addition to the routine treatment. Group D received IIT + LMWH and the routine treatment. The white blood cell count, hemodiastase, serum albumin, arterial partial pressure of oxygen and prothrombin time were recorded prior to treatment and 1, 3, 5, 7 and 14 days after the initiation of treatment. The intestinal function recovery time, incidence rate of multiple organ failure (MOF), length of hospitalization and fatality rates were observed. IIT + LMWH noticeably increased the white blood cell count, hemodiastase level, serum albumin level and the arterial partial pressure of oxygen in the patients with SAP (P<0.05). It markedly shortened the intestinal recovery time and the length of stay and reduced the incidence rate of MOF, the surgery rate and the fatality rate (P<0.05). It did not aggravate the hemorrhagic tendency of SAP (P>0.05). IIT + LMWH had a noticeably improved clinical curative effect on SAP compared with that of the other treatments.
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Jun-Dong
authors.initials: JD
authors.lastname: DU
authors.affiliation: Division Three for Senior Officers, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Hepatobiliary Surgery, The General Hospital of PLA, Beijing 100853, P.R. China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Huang
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Shou-Wang
authors.initials: SW
authors.lastname: Cai
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Jing-Wang
authors.initials: JW
authors.lastname: Tan
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Zhan-Liang
authors.initials: ZL
authors.lastname: Li
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yao
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Hua-Bo
authors.initials: HB
authors.lastname: Jiao
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Hui-Nan
authors.initials: HN
authors.lastname: Yin
authors.affiliation: Departments of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China.
authors.forename: Zi-Man
authors.initials: ZM
authors.lastname: Zhu
keywords: albumin; diastase; intensive insulin therapy; intestinal function recovery time; low molecular weight heparin anticoagulant therapy; severe acute pancreatitis; white blood cell