title: ABO blood group and von Willebrand factor: biological implications.
abstract: ABO blood group antigens are complex carbohydrate molecules expressed on the surface of red blood cells and a variety of human cells and tissues. It is well known that ABO blood type exerts a profound influence on hemostasis, being a major determinant of von Willebrand factor (VWF), and consequently factor VIII, plasma levels. In this review, we will focus on the molecular mechanisms underlying the interaction between ABO blood group and VWF in normal and pathological conditions.
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Silvia
authors.initials: S
authors.lastname: Crestani
authors.forename: Francesco
authors.initials: F
authors.lastname: Frattini
authors.forename: Cinzia
authors.initials: C
authors.lastname: Sissa
authors.forename: Carlo
authors.initials: C
authors.lastname: Bonfanti
mesh_terms: D000017:ABO Blood-Group System / Q000502:physiology*; D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D006031:Glycosylation; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D010641:Phenotype; D014842:von Willebrand Diseases / Q000097:blood; D014841:von Willebrand Factor / Q000737:chemistry / Q000502:physiology*
chemical_list: D000017:ABO Blood-Group System; D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human