title: Comparative Studies of Salivary and Blood Sialic Acid, Lipid Peroxidation and Antioxidative Status in Oral Squamous Cell Carcinoma (OSCC).
abstract: Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.
authors.affiliation: Mahmood Rasool, Center of Excellence in Genomic Medicine Research (CEGMR),King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Rasool
authors.affiliation: Saima Rubab Khan, Institute of molecular biology and biotechnology,The University of Lahore, Lahore, Pakistan.
authors.forename: Saima Rubab
authors.initials: SR
authors.lastname: Khan
authors.affiliation: Arif Malik, Institute of molecular biology and biotechnology,The University of Lahore, Lahore, Pakistan.
authors.forename: Arif
authors.initials: A
authors.lastname: Malik
authors.affiliation: Khalid Mahmood Khan, Fatima Jinaah Medical College, Sir Ganga Ram Hospital, Lahore, Pakistan.
authors.forename: Khalid Mahmood
authors.initials: KM
authors.lastname: Khan
authors.affiliation: Sara Zahid, Institute of molecular biology and biotechnology,The University of Lahore, Lahore, Pakistan.
authors.forename: Sara
authors.initials: S
authors.lastname: Zahid
authors.affiliation: Abdul Manan, Institute of molecular biology and biotechnology,The University of Lahore, Lahore, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Manan
authors.affiliation: Mahmood Husain Qazi, Centre for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan.
authors.forename: Mahmood Husain
authors.initials: MH
authors.lastname: Qazi
authors.affiliation: Muhammad Imran Naseer, Center of Excellence in Genomic Medicine Research (CEGMR),King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Naseer
keywords: Lipid peroxidation; MDA; Neoplastic; Squamous Cell Carcinoma