title: The primary nitrate response: a multifaceted signalling pathway.
abstract: Nitrate (NO3(-)) application strongly affects gene expression in plants. This regulation is thought to be crucial for their adaptation in response to a changing nutritional environment. Depending on the conditions preceding or concomitant with nitrate provision, the treatment can affect up to a 10th of genome expression in Arabidopsis thaliana. The early events occurring after NO3(-) provision are often called the Primary Nitrate Response (PNR). Despite this simple definition, PNR is a complex process that is difficult to properly delineate. Here we report the different concepts related to PNR, review the different molecular components known to control it, and show, using meta-analysis, that this concept/pathway is not monolithic. We especially bring our attention to the genome-wide effects of LBD37 and LBD38 overexpression, NLP7, and CHL1/NRT1.1 mutations.
authors.affiliation: Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, Institut de Biologie Intégrative des Plantes 'Claude Grignon', UMR CNRS/INRA/SupAgro/UM2, Place Pierre Viala, 34060 Montpellier cedex, France.
authors.forename: Anna
authors.initials: A
authors.lastname: Medici
authors.affiliation: Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, Institut de Biologie Intégrative des Plantes 'Claude Grignon', UMR CNRS/INRA/SupAgro/UM2, Place Pierre Viala, 34060 Montpellier cedex, France krouk@supagro.inra.fr.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Krouk
mesh_terms: D027321:Anion Transport Proteins / Q000235:genetics / Q000378:metabolism; D017360:Arabidopsis / Q000235:genetics / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D009154:Mutation; D009566:Nitrates / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism*; D018517:Plant Roots / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
chemical_list: D027321:Anion Transport Proteins; D029681:Arabidopsis Proteins; D009566:Nitrates; D009584:Nitrogen
keywords: CHL1/NRT1.1 mutations; LBD37/38; NLP7; Primary Nitrate Response (PNR).; nitrate (NO3–); nutritional environment