title: Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
abstract: BACKGROUND
  Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
  
  
  RESULTS
  In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10-6) and 14 (IGHV1-67 p = 7.9×10-8) which indexed novel susceptibility loci.
  
  
  CONCLUSIONS
  The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Valentina
authors.initials: V
authors.lastname: Escott-Price
authors.affiliation: Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Bellenguez
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors.forename: Li-San
authors.initials: LS
authors.lastname: Wang
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
authors.forename: Seung-Hoan
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Denise
authors.initials: D
authors.lastname: Harold
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Lesley
authors.initials: L
authors.lastname: Jones
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Holmans
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Amy
authors.initials: A
authors.lastname: Gerrish
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Alexey
authors.initials: A
authors.lastname: Vedernikov
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Alexander
authors.initials: A
authors.lastname: Richards
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
authors.forename: Anita L
authors.initials: AL
authors.lastname: DeStefano
authors.affiliation: Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
authors.affiliation: Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Carla A
authors.initials: CA
authors.lastname: Ibrahim-Verbaas
authors.affiliation: Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Naj
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sims
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
authors.forename: Gyungah
authors.initials: G
authors.lastname: Jun
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Bis
authors.affiliation: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Beecham
authors.affiliation: Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Grenier-Boley
authors.affiliation: Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Russo
authors.affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Tricia A
authors.initials: TA
authors.lastname: Thornton-Wells
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Nicola
authors.initials: N
authors.lastname: Denning
authors.affiliation: University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
authors.forename: Albert V
authors.initials: AV
authors.lastname: Smith
authors.affiliation: Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
authors.forename: Vincent
authors.initials: V
authors.lastname: Chouraki
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Charlene
authors.initials: C
authors.lastname: Thomas
authors.affiliation: Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
authors.forename: M Arfan
authors.initials: MA
authors.lastname: Ikram
authors.affiliation: Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
authors.forename: Diana
authors.initials: D
authors.lastname: Zelenika
authors.affiliation: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
authors.forename: Badri N
authors.initials: BN
authors.lastname: Vardarajan
authors.affiliation: Fondation Jean Dausset- CEPH, Paris, France.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kamatani
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors.forename: Chiao-Feng
authors.initials: CF
authors.lastname: Lin
authors.affiliation: Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
authors.forename: Helena
authors.initials: H
authors.lastname: Schmidt
authors.affiliation: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
authors.forename: Brian
authors.initials: B
authors.lastname: Kunkle
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Melanie L
authors.initials: ML
authors.lastname: Dunstan
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Maria
authors.initials: M
authors.lastname: Vronskaya
authors.affiliation: NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Johnson
authors.affiliation: Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Agustin
authors.initials: A
authors.lastname: Ruiz
authors.affiliation: Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Bihoreau
authors.affiliation: Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
authors.forename: Christiane
authors.initials: C
authors.lastname: Reitz
authors.affiliation: Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Hollingworth
authors.affiliation: University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hanon
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America.
authors.forename: Annette L
authors.initials: AL
authors.lastname: Fitzpatrick
authors.affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America; Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Buxbaum
authors.affiliation: CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Crane
authors.affiliation: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America.
authors.forename: Clinton
authors.initials: C
authors.lastname: Baldwin
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Becker
authors.affiliation: University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.affiliation: Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cruchaga
authors.affiliation: Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Craig
authors.affiliation: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Najaf
authors.initials: N
authors.lastname: Amin
authors.affiliation: INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.affiliation: Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
authors.forename: Oscar L
authors.initials: OL
authors.lastname: Lopez
authors.affiliation: Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America.
authors.forename: Philip L
authors.initials: PL
authors.lastname: De Jager
authors.affiliation: Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Deramecourt
authors.affiliation: Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
authors.forename: Janet A
authors.initials: JA
authors.lastname: Johnston
authors.affiliation: Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.
authors.forename: Denis
authors.initials: D
authors.lastname: Evans
authors.affiliation: King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.affiliation: Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Letenneur
authors.affiliation: Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
authors.forename: David C
authors.initials: DC
authors.lastname: Rubinsztein
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland.
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.affiliation: Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
authors.forename: Kristel
authors.initials: K
authors.lastname: Sleegers
authors.affiliation: Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Goate
authors.affiliation: Inserm U744, Lille, France; Institut Pasteur de Lille, Lille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Fiévet
authors.affiliation: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Huentelman
authors.affiliation: Discipline of Psychiatry, Trinity College, Dublin, Ireland.
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.affiliation: Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Kristelle
authors.initials: K
authors.lastname: Brown
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
authors.forename: M Ilyas
authors.initials: MI
authors.lastname: Kamboh
authors.affiliation: Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
authors.forename: Lina
authors.initials: L
authors.lastname: Keller
authors.affiliation: King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
authors.forename: Pascale
authors.initials: P
authors.lastname: Barberger-Gateau
authors.affiliation: Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
authors.forename: Bernadette
authors.initials: B
authors.lastname: McGuinness
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health, Seattle, Washington, United States of America.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Larson
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Myers
authors.affiliation: Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.affiliation: Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Todd
authors.affiliation: CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
authors.forename: David
authors.initials: D
authors.lastname: Wallon
authors.affiliation: University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom.
authors.forename: Seth
authors.initials: S
authors.lastname: Love
authors.affiliation: Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Rogaeva
authors.affiliation: Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Gallacher
authors.affiliation: Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Peter St
authors.initials: PS
authors.lastname: George-Hyslop
authors.affiliation: Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Clarimon
authors.affiliation: Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Lleo
authors.affiliation: Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Bayer
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America.
authors.forename: Debby W
authors.initials: DW
authors.lastname: Tsuang
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.affiliation: Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Bossù
authors.affiliation: Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Spalletta
authors.affiliation: King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
authors.forename: Petra
authors.initials: P
authors.lastname: Proitsi
authors.affiliation: MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Collinge
authors.affiliation: NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.affiliation: Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
authors.forename: Florentino Sanchez
authors.initials: FS
authors.lastname: Garcia
authors.affiliation: Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.affiliation: Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
authors.forename: Maria Candida Deniz
authors.initials: MC
authors.lastname: Naranjo
authors.affiliation: IRCCS Associazione Oasi Maria SS, Troina, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bosco
authors.affiliation: Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Clarke
authors.affiliation: Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Carol
authors.initials: C
authors.lastname: Brayne
authors.affiliation: University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Galimberti
authors.affiliation: University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
authors.affiliation: Neurological Clinic, University of Pisa, Pisa, Italy.
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
authors.affiliation: Neurological Clinic, University of Pisa, Pisa, Italy.
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
authors.affiliation: Neurological Clinic, University of Pisa, Pisa, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siciliano
authors.affiliation: Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.affiliation: Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
authors.affiliation: Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
authors.forename: Maria Del
authors.initials: MD
authors.lastname: Zompo
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.affiliation: Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.); Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
authors.affiliation: Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pilotto
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto de Investigación Sanitaria "Hospital la Paz" (IdIPaz), Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Frank-García
authors.affiliation: Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.affiliation: Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
authors.affiliation: Department of Neuroscience-University of Parma, Parma, Italy; Center for Cognitive Disorders AUSL, Parma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Caffarra
authors.affiliation: NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.affiliation: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
authors.forename: William
authors.initials: W
authors.lastname: Perry
authors.affiliation: Department Of Psychiatry, University Hospital, Saarland, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Mayhaus
authors.affiliation: Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Lannfelt
authors.affiliation: Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
authors.affiliation: Department Of Psychiatry, University Hospital, Saarland, Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pichler
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
authors.forename: Minerva M
authors.initials: MM
authors.lastname: Carrasquillo
authors.affiliation: Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Ingelsson
authors.affiliation: National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America.
authors.forename: Duane
authors.initials: D
authors.lastname: Beekly
authors.affiliation: Genetica molecular-Huca-Oviedo, Oviedo, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
authors.forename: Fanggeng
authors.initials: F
authors.lastname: Zou
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors.forename: Otto
authors.initials: O
authors.lastname: Valladares
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Younkin
authors.affiliation: Genetica molecular-Huca-Oviedo, Oviedo, Spain.
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.affiliation: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
authors.forename: Kara L
authors.initials: KL
authors.lastname: Hamilton-Nelson
authors.affiliation: Department of Psychiatry, University Hospital, Saarland, Germany.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Razquin
authors.affiliation: Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Pastor
authors.affiliation: Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Mateo
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.affiliation: Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
authors.forename: Kelley M
authors.initials: KM
authors.lastname: Faber
authors.affiliation: University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Landspitali University Hospital, Reykjavik, Iceland.
authors.forename: Palmi V
authors.initials: PV
authors.lastname: Jonsson
authors.affiliation: Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
authors.forename: Onofre
authors.initials: O
authors.lastname: Combarros
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors.forename: Laura B
authors.initials: LB
authors.lastname: Cantwell
authors.affiliation: Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Deborah
authors.initials: D
authors.lastname: Blacker
authors.affiliation: MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
authors.forename: Simon
authors.initials: S
authors.lastname: Mead
authors.affiliation: Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mosley
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Laura
authors.initials: L
authors.lastname: Fratiglioni
authors.affiliation: Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom.
authors.forename: Clive
authors.initials: C
authors.lastname: Holmes
authors.affiliation: Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Renee F A G
authors.initials: RF
authors.lastname: de Bruijn
authors.affiliation: Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Passmore
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Montine
authors.affiliation: Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
authors.forename: Karolien
authors.initials: K
authors.lastname: Bettens
authors.affiliation: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France; AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.affiliation: Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Kevin
authors.initials: K
authors.lastname: Morgan
authors.affiliation: Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
authors.forename: Tatiana M
authors.initials: TM
authors.lastname: Foroud
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Kukull
authors.affiliation: CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
authors.affiliation: King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
authors.forename: John F
authors.initials: JF
authors.lastname: Powell
authors.affiliation: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Nalls
authors.affiliation: INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Imperial College, London, United Kingdom.
authors.forename: Karen
authors.initials: K
authors.lastname: Ritchie
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Lunetta
authors.affiliation: Department of Biology, Brigham Young University, Provo, Utah, United States of America.
authors.forename: John S K
authors.initials: JS
authors.lastname: Kauwe
authors.affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America; Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: Department of Psychiatry, University Hospital, Saarland, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Riemenschneider
authors.affiliation: Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain; Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Boada
authors.affiliation: Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Hiltunen
authors.affiliation: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
authors.forename: Eden R
authors.initials: ER
authors.lastname: Martin
authors.affiliation: Department of Neurology, Medical University Graz, Graz, Austria.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schmidt
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.affiliation: Inserm U897, Victor Segalen University, F-33076, Bordeaux, France; Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.affiliation: Inserm U708, Victor Segalen University, Bordeaux, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.affiliation: Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.affiliation: Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden.
authors.forename: Caroline
authors.initials: C
authors.lastname: Graff
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.affiliation: Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.affiliation: Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Fondation Jean Dausset- CEPH, Paris, France; McGill University and Génome Québec Innovation Centre, Montreal, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.affiliation: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.affiliation: Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
authors.affiliation: Netherlands Consortium for Healthy Aging, Leiden, The Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.affiliation: Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ramirez
authors.affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; The Framingham Heart Study, Framingham, Massachusetts, United States of America.
authors.forename: Sudha
authors.initials: S
authors.lastname: Seshadri
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Schellenberg
authors.affiliation: Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Centre Hospitalier Régional Universitaire de Lille, Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
authors.forename: Julie
authors.initials: J
authors.lastname: Williams
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D055106:Genome-Wide Association Study; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011947:Receptors, Antigen, B-Cell / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D011947:Receptors, Antigen, B-Cell; C429767:TP53INP1 protein, human