title: Mucormycosis Rhinosinusitis at Diagnosis of Acute Lymphoblastic Leukemia: Diagnostics and Management Challenges in a Low-Middle-income Country.
abstract: We present the case of an adolescent with mucor rhinosinusitis diagnosed concomitantly with acute lymphoblastic leukemia at a hospital in Tegucigalpa, Honduras. We also discuss the challenges faced in the dual management of hematologic malignancies and invasive fungal disease in a low-middle-income country, such as access to diagnostics, immunosuppressants, imaging, and antifungals. Despite these shortcomings, the patient was successfully treated for both the diseases. Low-middle-income country hospitals can effectively treat invasive fungal diseases by providing adequate diagnostic and support services, which can improve the outcomes of pediatric cancer patients.
authors.affiliation: *Hospital Universitario, Tegucigalpa, Honduras †Department of Infectious Diseases §International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN ‡Department of Infectious Diseases, Duke University Medical Center, Durham, NC.
authors.forename: Elham
authors.initials: E
authors.lastname: Mandegari
authors.forename: Ligia
authors.initials: L
authors.lastname: Fu
authors.forename: Carolina
authors.initials: C
authors.lastname: Arambú
authors.forename: Sandra
authors.initials: S
authors.lastname: Montoya
authors.forename: Armando
authors.initials: A
authors.lastname: Peña
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Johnson
authors.forename: John R
authors.initials: JR
authors.lastname: Perfect
authors.forename: Miguela A
authors.initials: MA
authors.lastname: Caniza
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D003906:Developing Countries; D019468:Disease Management; D006297:Health Services Accessibility; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D011379:Prognosis; D012220:Rhinitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D012852:Sinusitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents