title: A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial.
abstract: Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.
authors.affiliation: Kessler Foundation Research Center, 300 Executive Drive, Suite 70, West Orange, NJ, 07052, USA.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Dobryakova
authors.forename: Glenn R
authors.initials: GR
authors.lastname: Wylie
authors.forename: John
authors.initials: J
authors.lastname: DeLuca
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Chiaravalloti
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D020528:Multiple Sclerosis, Chronic Progressive / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D009483:Neuropsychological Tests; D010865:Pilot Projects; D016896:Treatment Outcome