title: Prostatic artery embolization for prostate volume greater than 80 cm3: results from a single-center prospective study.
abstract: OBJECTIVE
  To investigate clinical benefits and safety of prostatic artery embolization (PAE) in patients with prostate volume ≥80 cm(3) and Charlson comorbidity index (CCI) ≥2 and affected by benign prostatic obstruction (BPO).
  
  
  METHODS
  From January 2009 to January 2012, PAE was performed in 88 consecutive patients affected by clinical BPO. Inclusion criteria were symptomatic BPO refractory to medical treatment, International Prostate Symptom Score (IPSS) ≥12, total prostate volume (TPV) ≥80 cm(3), Qmax <15 mL/s, and CCI ≥2. Primary end points were the reduction of 7 points of the IPSS and the increase of Qmax. Secondary end points were the reduction of TPV, postvoid residue (PVR), prostate-specific antigen (PSA), International Index of Erectile Function 5 score, and IPSS-quality of life (QoL). Follow-up was addressed at 3 months, 6 months, and at 1 year.
  
  
  RESULTS
  The mean IPSS (10.40 vs 23.98; P <.05) and the mean Qmax (16.89 vs 7.28; P <.05) at 1 year were significantly different with respect to baseline. When considering secondary end points, we observed significant variation in terms of PVR (18.38 vs 75.25; P <.05), TPV (71.20 vs 129.31; P <.05), and PSA level (2.12 vs 3.67; P <.05) at 1 year compared with baseline. Finally, the mean IPSS-QoL significantly changed from baseline to 1 year after PAE (5.10 vs 2.20; P <.05). No minor or major complications were reported.
  
  
  CONCLUSIONS
  We showed clinical benefits of PAE for the treatment of lower urinary tract symptoms and/or BPO by reducing IPSS, TPV, PSA, PVR, and improvement in urinary flow and QoL after 1 year in patients with prostate volume ≥80 cm(3) and CCI ≥2.
authors.affiliation: Andrological and Urological Department, Endocrinological Research Center, Moscow, Russia.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Kurbatov
authors.affiliation: Department of Urology, University of Catania, Catania, Italy.
authors.forename: Giorgio Ivan
authors.initials: GI
authors.lastname: Russo
authors.affiliation: Andrological and Urological Department, Endocrinological Research Center, Moscow, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Lepetukhin
authors.affiliation: Andrological and Urological Department, Endocrinological Research Center, Moscow, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Dubsky
authors.affiliation: Andrological and Urological Department, Endocrinological Research Center, Moscow, Russia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Sitkin
authors.affiliation: Department of Urology, University of Catania, Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morgia
authors.affiliation: Andrological and Urological Department, Endocrinological Research Center, Moscow, Russia.
authors.forename: Roman
authors.initials: R
authors.lastname: Rozhivanov
authors.affiliation: Department of Urology, University of Catania, Catania, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Cimino
authors.affiliation: Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy. Electronic address: salvatore.sansalone@yahoo.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sansalone
mesh_terms: D000368:Aged; D001158:Arteries; D004621:Embolization, Therapeutic; D006801:Humans; D008297:Male; D009929:Organ Size; D011446:Prospective Studies; D011467:Prostate / Q000098:blood supply* / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology / Q000628:therapy*