title: Phytotoxic cis-clerodane diterpenoids from the Chinese liverwort Scapania stephanii.
abstract: Five cis-clerodane diterpenoids, stephanialides A-E, along with seven known cis-clerodanes, scaparvins A-C, parvitexins B and C, 3-chloro-4-hydroxy-parvitexin A, and scapanialide B, were isolated from the Chinese liverwort Scapania stephanii. Their structures were established unequivocally on the basis of spectroscopic data. The absolute configuration of stephanialide A was determined by analysis of CD data using the octant rule. Phytotoxic activity evaluation showed that this type of diterpenoids can significantly inhibit root elongation of the seeds of Arabidopsis thaliana, Lepidium sativum and Brassica pekinensis.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Li
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: National Glycoengineering Research Center, Shandong University, Jinan 250012, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Liu
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.affiliation: Guangxi Mount. Maoer National Nature Reserve, Guilin 541001, PR China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Ye
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, United States.
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China. Electronic address: louhongxiang@sdu.edu.cn.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000187:drug effects; D001937:Brassica / Q000187:drug effects; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035926:Hepatophyta / Q000737:chemistry*; D031220:Lepidium sativum / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000187:drug effects / Q000254:growth & development; D012639:Seeds / Q000187:drug effects / Q000254:growth & development; D013237:Stereoisomerism
chemical_list: D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal
keywords: Bryophytes; Liverworts; Phytotoxic activities; Scapania stephanii; Scapaniaceae; Stephanialides A−E; cis-Clerodane diterpenoids