title: Odor identification in frontotemporal lobar degeneration subtypes.
abstract: Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear palsy. Compared to the control group (n = 15), all FTLD subgroups showed significant impairment of odor identification (P < .05). The differences between the FTLD subgroups were not significant. No correlation between odor identification and neuropsychological tests results was found. Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline.
authors.affiliation: Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic magerova.hana@gmail.com.
authors.forename: Hana
authors.initials: H
authors.lastname: Magerova
authors.affiliation: Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Vyhnalek
authors.affiliation: Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Laczo
authors.affiliation: University of South Florida, School of Aging Studies, Tampa, FL, USA.
authors.forename: Ross
authors.initials: R
authors.lastname: Andel
authors.affiliation: First Department of Neurology, School of Medicine and St Anne's Hospital, Masaryk University, Brno, Czech Republic Applied Neurosciences Research Group, CEITEC, Masaryk University, Brno, Czech Republic.
authors.forename: Irena
authors.initials: I
authors.lastname: Rektorova
authors.affiliation: Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kadlecova
authors.affiliation: Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Bojar
authors.affiliation: Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Hort
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications* / Q000503:physiopathology; D057174:Frontotemporal Lobar Degeneration / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009812:Odorants; D000857:Olfaction Disorders / Q000150:complications* / Q000503:physiopathology; D057178:Primary Progressive Nonfluent Aphasia / Q000150:complications* / Q000503:physiopathology; D012720:Severity of Illness Index; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000503:physiopathology
keywords: behavioral variant frontotemporal dementia; cognitive status; odor identification; primary nonfluent aphasia; progressive supranuclear palsy; semantic dementia