title: Relationship of lipid parameters with bone mineral density in Indian population.
abstract: BACKGROUND
  Cardiovascular disease and osteoporosis share common risk factors including dyslipidemia. There are conflicting reports of differential relation of various lipid parameters on bone mineral density (BMD). Hence, we studied the correlation between lipid parameters and BMD in healthy adult.
  
  
  METHODS
  A total of 2347 participants (male 39.4%; female 60.6%) included in this cross-sectional study were divided according to sex and age. Fasting blood samples were drawn for biochemical parameters. BMD at lumbar spine, femur, and forearm were measured by dual energy X-ray absorptiometry (DXA).
  
  
  RESULTS
  In males, BMD at femur and lumbar spine decreased significantly with increasing quartiles of total cholesterol (TC) (P < 0.0001, and 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.001, and 0.01). In premenopausal women, BMD at femoral neck (P = 0.001) and lumbar spine (P = 0.029) showed declining trend with LDL-c (P = 0.007). In postmenopausal women, only BMD at total femur decreased significantly with TC (P = 0.024) and LDL-c (P = 0.036). All above findings were confirmed in correlation studies. In multiple regression analysis after adjusting for age, body mass index, ionized calcium, alkaline phosphatase, 25 hydroxy vitamin D, and parathyroid hormone levels correlation of BMD with TC and LDL-c persisted. TC, LDL-c was higher in subjects with low bone density compared those with normal bone density in both sexes.
  
  
  CONCLUSIONS
  TC and LDL-c had weak but significant negative correlation with BMD at femur and lumbar spine.
authors.affiliation: Department of Endocrinology and Metabolism, Command Hospital (Southern Command), Pune, Maharastra, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Garg
authors.affiliation: Department of Endocrinology and Metabolism, International Life Sciences Institute-India, New Delhi, India.
authors.forename: Raman K
authors.initials: RK
authors.lastname: Marwaha
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Tandon
authors.affiliation: Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
authors.forename: Kuntal
authors.initials: K
authors.lastname: Bhadra
authors.affiliation: Department of Pathology, Biochemistry Division, Deenanath Mangeshkar Hospital and Research Center, Erandawane, Pune, Maharashtra, India.
authors.forename: N
authors.initials: N
authors.lastname: Mahalle
keywords: Bone mineral density; dual energy X-ray absorptiometry; high-density lipoprotein-cholesterol; lipid Profile; low-density lipoprotein-cholesterol; total cholesterol; triglycerides