title: Mannosylation of fungal glycoconjugates in the Golgi apparatus.
abstract: Glycosylation is a crucial step in the modification of proteins or sphingolipids that then play a prominent role in fungal biology. Glycosylation controls the structure and plasticity of the fungal cell wall and fungi-host interactions. Non-pathogenic and pathogenic yeasts, such as Saccharomyces cerevisiae and Candida albicans, respectively, have been useful models for analyzing the mannosylation of proteins and sphingolipids, which mainly takes place in the Golgi apparatus. Studies of these yeasts have identified different mannosyltransferases that belong to separate families of glycosyltransferases. The characterization of mannosyltransferases and their activities is essential for deciphering cell wall biogenesis, for identifying mannosides involved in virulence and for designing inhibitors that target specific mannosylation processes.
authors.affiliation: Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, 59650 Villeneuve d'Ascq, France; CNRS, UMR 8576, 59650 Villeneuve d'Ascq, France.
authors.forename: Emeline
authors.initials: E
authors.lastname: Fabre
authors.affiliation: Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, 59650 Villeneuve d'Ascq, France; CNRS, UMR 8576, 59650 Villeneuve d'Ascq, France; Unité Inserm 995, 59000 Lille, France; Université Lille 2, Group"Candida and Candidiasis", Faculté de Médecine, 59000 Lille, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hurtaux
authors.affiliation: Unité Inserm 995, 59000 Lille, France; Université Lille 2, Group"Candida and Candidiasis", Faculté de Médecine, 59000 Lille, France. Electronic address: chantal.fradin@univ-lille2.fr.
authors.forename: Chantal
authors.initials: C
authors.lastname: Fradin
mesh_terms: D002176:Candida albicans / Q000201:enzymology / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D006001:Glycoconjugates / Q000378:metabolism*; D006031:Glycosylation; D006056:Golgi Apparatus / Q000201:enzymology / Q000378:metabolism*; D008358:Mannose / Q000378:metabolism*; D008364:Mannosyltransferases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D006001:Glycoconjugates; D013107:Sphingolipids; D008364:Mannosyltransferases; D008358:Mannose