title: Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.
abstract: TIA (T-cell intracellular antigens)-knockdown HeLa cells show an increase in ribosomes and translational machinery components. This increase correlates with specific changes in translationally up-regulated mRNAs involved in cell-cycle progression and DNA repair, as shown in polysomal profiling analysis. Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells.
authors.affiliation: *Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid (CSIC/UAM), C/ Nicolás Cabrera 1, Cantoblanco, DP 28049 Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Carrascoso
authors.affiliation: *Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid (CSIC/UAM), C/ Nicolás Cabrera 1, Cantoblanco, DP 28049 Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Sánchez-Jiménez
authors.affiliation: *Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid (CSIC/UAM), C/ Nicolás Cabrera 1, Cantoblanco, DP 28049 Madrid, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Izquierdo
mesh_terms: D020869:Gene Expression Profiling / Q000379:methods*; D055106:Genome-Wide Association Study / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D007424:Intracellular Fluid / Q000276:immunology; D039102:Poly(A)-Binding Proteins / Q000235:genetics / Q000502:physiology*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D000074019:T-Cell Intracellular Antigen-1; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D015533:Transcriptional Activation / Q000276:immunology
chemical_list: D039102:Poly(A)-Binding Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; C076751:TIAL1 protein, human