title: FAS and FAS ligand gene polymorphisms in Egyptian females with preeclampsia.
abstract: We aimed to evaluate the association of Fas polymorphism and the Fas ligand with preeclampsia, investigating whether the G 670 Fas gene variant and the Fas Ligand INV2nt 124 G variant had a differential distribution in patients with preeclampsia. The preeclamptic group consisted of 50 pregnant women who developed preeclampsia, while the control group consisted of 50 age-matched pregnant women with uncomplicated pregnancies. Fas and Fas ligand gene polymorphisms were tested using polymerase chain reaction-restriction fragment length polymorphism. Regarding the Fas 670 A>G polymorphism, statistically significant differences were found between the two groups regarding the AA and GG/AG genotypes as well as the A, G allele frequency, while no statistically significant differences were found regarding AG or GG genotypes. Regarding the FasLG IVS2nt 124 A>G polymorphism, no statistically significant differences were found between the two groups studied. Concerning the Fas 670 A>G gene, no statistically significant differences between the severe and mild preeclampsia groups regarding the A allele frequency were found. Concerning the FasLG IVS2nt 124 A>G gene, there were no statistically significant differences between the severe and mild preeclampsia groups regarding the A allele frequency or the G allele frequency. The presence of the Fas gene polymorphism Fas A670G is associated with an increased risk of preeclampsia, while the presence of FasLG IVS2nt 124 A>G gene may be protective against preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Nasr
authors.affiliation: Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Asmaa A
authors.initials: AA
authors.lastname: Abdel Aal
authors.affiliation: Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt. Electronic address: amlsoliman78@yahoo.com.
authors.forename: Aml
authors.initials: A
authors.lastname: Soliman
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Khaled A A E L
authors.initials: KA
authors.lastname: Setohy
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Mona F
authors.initials: MF
authors.lastname: Shehata
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004534:Egypt; D053222:Fas Ligand Protein / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics* / Q000276:immunology; D011247:Pregnancy; D019014:fas Receptor / Q000235:genetics* / Q000276:immunology
chemical_list: C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D019014:fas Receptor
keywords: Fas; Fas ligand genes; Gene polymorphisms; Preeclampsia