title: Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats.
abstract: BACKGROUND
  Laparoscopic appendectomy (LA) has become one of the most common surgical procedures to date. To improve and standardize this technique further, cost-effective and reliable animal models are needed.
  
  
  METHODS
  In a pilot study, 30 Wistar rats underwent laparoscopic caecum resection (as rats do not have an appendix vermiformis), to optimize the instrumental and surgical parameters. A subsequent test study was performed in another 30 rats to compare three different techniques for caecum resection and bowel closure.
  
  
  RESULTS
  Bipolar coagulation led to an insufficiency of caecal stump closure in all operated rats (Group 1, n = 10). Endoloop ligation followed by bipolar coagulation and resection (Group 2, n = 10) or resection with a LigaSure™ device (Group 3, n = 10) resulted in sufficient caecal stump closure.
  
  
  CONCLUSIONS
  We developed a LA model enabling us to compare three different caecum resection techniques in rats. In conclusion, only endoloop closure followed by bipolar coagulation proved to be a secure and cost-effective surgical approach.
authors.affiliation: Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany. philipp.lingohr@ukb.uni-bonn.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Lingohr
authors.forename: Jonas
authors.initials: J
authors.lastname: Dohmen
authors.forename: Hanno
authors.initials: H
authors.lastname: Matthaei
authors.forename: Timo
authors.initials: T
authors.lastname: Schwandt
authors.forename: Gun-Soo
authors.initials: GS
authors.lastname: Hong
authors.forename: Nils
authors.initials: N
authors.lastname: Konieczny
authors.forename: Edwin
authors.initials: E
authors.lastname: Bölke
authors.forename: Sven
authors.initials: S
authors.lastname: Wehner
authors.forename: Jörg C
authors.initials: JC
authors.lastname: Kalff
mesh_terms: D000818:Animals; D001062:Appendectomy / Q000379:methods*; D002432:Cecum / Q000601:surgery*; D003362:Cost-Benefit Analysis; D006801:Humans; D008026:Ligation / Q000379:methods; D023421:Models, Animal; D051381:Rats