title: The distinct abilities of tube-formation and migration between brain and spinal cord microvascular pericytes in rats.
abstract: Pericytes are contractile cells that wrap around the endothelial cells of capillaries throughout the body. They play an important role in regulating the blood brain barrier (BBB) and blood spinal cord barrier (BSCB). The differences between brain and spinal cord microvascular endothelial cells have been investigated. However, no report has elucidated the similarities and differences between brain microvascular pericytes (BMPs) and spinal cord microvascular pericytes (SCMPs) in vitro. The similarities were found between the two types of pericytes not only in the proliferation ability but also in the expression of toll like receptor 4. On the other hand, BMPs showed more than 2 fold in tubular length formation compared with SCMPs. The number of migratory SCMPs was larger than that of migratory BMPs. The expressions of connexin 43 and vascular endothelial growth factor (VEGF) in BMPs were increased compared with those in SCMPs, while SCMPs expressed more desmin and N-cadherin than BMPs. The abilities of tube-formation and migration between BMPs and SCMPs were markedly different, which might be mediated by VEGF, connexin 43, N-cadherin and desmin. These distinguishing features may reflect the more widespread differences between the BBB and BSCB which directly impact pathophysiological processes in various major diseases.
authors.forename: Qingbin
authors.initials: Q
authors.lastname: Wu
authors.forename: Yingli
authors.initials: Y
authors.lastname: Jing
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Yuan
authors.forename: Bingwei
authors.initials: B
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Mingming
authors.initials: M
authors.lastname: Liu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Li
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Xiu
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000166:cytology*; D001921:Brain / Q000166:cytology*; D002465:Cell Movement; D042783:Endothelial Cells / Q000378:metabolism*; D008297:Male; D020286:Pericytes / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000166:cytology*
keywords: Brain microvasular pericytes; blood brain barrier; blood spinal cord barrier; central nervous system