title: Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese population: the Takahata study.
abstract: BACKGROUND
  Adiponectin is an anti-inflammatory and cardio-protective cytokine. However, several studies have demonstrated that plasma adiponectin levels were inversely associated with pulmonary function in patients with chronic obstructive pulmonary disease, suggesting a proinflammatory or pulmonary-destructive role. It is still unclear whether adiponectin is a potent biomarker predicting declines in pulmonary function. The aim of this study was to investigate the association between adiponectin and pulmonary function among Japanese individuals who participated in an annual health check-up.
  
  
  METHODS
  Spirometry and blood sampling, including measurements of plasma adiponectin, were performed for 3,253 subjects aged 40 years or older who participated in a community-based annual health check-up in Takahata, Japan from 2004 to 2006. In 2011, spirometry was re-performed, and the data from 872 subjects (405 men and 467 women) were available for a longitudinal analysis.
  
  
  RESULTS
  Plasma adiponectin levels were found to be significantly associated with age, body mass index (BMI), and alanine aminotransferase (ALT), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-c) levels among both men and women in the study population. Plasma adiponectin levels were found to be associated with lifetime cigarette consumption (Brinkman index, BI) in men only. Plasma adiponectin levels were inversely correlated with forced expiratory volume in 1 s (FEV1) per forced vital capacity in both men and women. In addition, the annual change in FEV1 was inversely associated with plasma adiponectin levels in both genders. A multiple linear regression analysis revealed that this association was independent of other confounding factors such as age, BMI, BI, ALT, TG, and HDL-c.
  
  
  CONCLUSIONS
  The results of the present study suggest that adiponectin levels are predictive of declines in FEV1 in the general population.
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Kento
authors.initials: K
authors.lastname: Sato
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Keiko
authors.initials: K
authors.lastname: Nunomiya
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Masamichi
authors.initials: M
authors.lastname: Sato
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kimura
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Takako
authors.initials: T
authors.lastname: Nemoto
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.affiliation: 2. Global Center of Excellence Program Study Group, Yamagata University School of Medicine, 2-2-2 Iida-Nishi Yamagata 990-9585, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.affiliation: 2. Global Center of Excellence Program Study Group, Yamagata University School of Medicine, 2-2-2 Iida-Nishi Yamagata 990-9585, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.affiliation: 2. Global Center of Excellence Program Study Group, Yamagata University School of Medicine, 2-2-2 Iida-Nishi Yamagata 990-9585, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007564:Japan; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012907:Smoking; D013147:Spirometry
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL
keywords: Adiponectin; Decline in FEV1; General population; Pulmonary function; Spirometry.