title: Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs.
abstract: Multisite organic-inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation.
authors.affiliation: Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
authors.forename: Antonio
authors.initials: A
authors.lastname: Leyva-Pérez
authors.forename: Pilar
authors.initials: P
authors.lastname: García-García
authors.forename: Avelino
authors.initials: A
authors.lastname: Corma
mesh_terms: D000613:Aminobutyrates / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D018682:GABA Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D006868:Hydrolysis; D007287:Inorganic Chemicals / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000613:Aminobutyrates; D018682:GABA Agents; D007287:Inorganic Chemicals; D009930:Organic Chemicals
keywords: GABAergic drug synthesis; domino reactions; heterogeneous catalysis; organic-inorganic hybrid catalysts; γ-aminobutyric acid