title: Anaphylactic reaction to pemetrexed: a case report.
abstract: Pemetrexed is approved to treat non-small cell lung cancer and has an overall favorable toxicity profile. We describe a 58-year-old man who developped an anaphylactic shock within few minutes from the beginning of pemetrexed perfusion. Pemetrexed was discontinued and the patient's symptoms gradually resolved with administration of symptomatic treatment. Serum tryptase level remained normal and intra dermal skin tests were negative eventhough a nonspecific papule was noted. This case suggests that caution should be exercised when prescribing pemetrexed and clinicians must be warranted for the possibility of serious adverse events associated with pemetrexed use.
authors.affiliation: Oncopharma, Hôpital Nord, AP-HM, Marseille, France.
authors.forename: Héloise
authors.initials: H
authors.lastname: Capelle
authors.forename: Joelle
authors.initials: J
authors.lastname: Birnbaum
authors.forename: Pascale
authors.initials: P
authors.lastname: Tomasini
authors.forename: Céline
authors.initials: C
authors.lastname: Tummino
authors.forename: Marion
authors.initials: M
authors.lastname: Gouitaa
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ausias
authors.forename: Denis
authors.initials: D
authors.lastname: Charpin
authors.forename: Fabrice
authors.initials: F
authors.lastname: Barlesi
authors.forename: Marc
authors.initials: M
authors.lastname: Montana
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000601:surgery; D005971:Glutamates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D000068437:Pemetrexed
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine