title: [Chemotherapy and targeted therapies in the management of brain metastases].
abstract: In case of cancer dissemination to the brain, surgery and radiosurgery of all the brain metastases must be considered when possible. In other cases, whole brain radiotherapy remains the standard of care. The place of chemotherapy in this strategy remains debated. New targeted therapy, which might be even more efficient than cytotoxic chemotherapy, will probably challenge upfront radiotherapy in the next years to come.
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Carpentier
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology; D017024:Chemotherapy, Adjuvant / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008545:Melanoma / Q000556:secondary / Q000628:therapy; D016634:Radiosurgery / Q000379:methods; D018714:Radiotherapy, Adjuvant / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000473:pathology; D016896:Treatment Outcome