title: Bone densitometry by dual-energy X-ray absorptiometry (DXA) in preterm newborns compared with full-term peers in the first six months of life.
abstract: OBJECTIVE
  To longitudinally assess bone mineral content (BMC), bone mineral density (BMD), and whole-body lean mass obtained through bone densitometry by dual-energy X-ray absorptiometry (DXA) in preterm newborns (PTNs) and compare them with full-term newborns (FTNs) from birth to 6 months of corrected postnatal age.
  
  
  METHODS
  A total of 28 adequate for gestational age (AGA) newborns were studied: 14 preterm and 14 full-term newborns. DXA was used to determine BMC, BMD, and lean mass in three moments: 40 weeks corrected post-conceptual age, as well as 3 and 6 months of corrected postnatal age. PTNs had gestational age ≤ 32 weeks at birth and were fed their mother's own milk or milk from the human milk bank.
  
  
  RESULTS
  All infants had an increase in BMC, BMD, and lean body mass values during the study. PTNs had lower BMC, BMD, and lean mass at 40 weeks of corrected post-conceptual age in relation to FTNs (p<0.001, p<0.001, p=0.047, respectively). However, there was an acceleration in the mineralization process of PTNs, which was sufficient to achieve the normal values of FTNs at 6 months of corrected age.
  
  
  CONCLUSIONS
  This study suggests that bone densitometry by dual-energy X-ray absorptiometry is a good method for the assessment of body composition parameters at baseline, and at the follow-up of these PTNs.
authors.affiliation: Human Milk Bank, Hospital Universitário, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Electronic address: virginia@hu.usp.br.
authors.forename: Virginia S
authors.initials: VS
authors.lastname: Quintal
authors.affiliation: Department of Pediatrics, Hospital Universitário, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Edna M A
authors.initials: EM
authors.lastname: Diniz
authors.affiliation: Division of Rheumatology, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Valeria de F
authors.initials: Vde F
authors.lastname: Caparbo
authors.affiliation: Division of Rheumatology, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors.forename: Rosa M R
authors.initials: RM
authors.lastname: Pereira
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000469:Alkaline Phosphatase / Q000097:blood; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D001938:Brazil; D002118:Calcium / Q000097:blood; D002657:Child Development / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008895:Milk, Human; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy
chemical_list: D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Bone mineralization; Densitometria; Densitometry; Human milk; Leite humano; Mineralização óssea; Newborn; Prematuridade; Prematurity; Recém-nascido