title: The COX-2 -765 G>C polymorphism is associated with increased risk of gastric carcinogenesis in the Chinese Hui ethnic population.
abstract: BACKGROUND
  The Chinese Hui ethnic group has diverse origins, including Arab, Persian, Central Asian, and Mongol. The standardized mortality rate of gastric cancer in the Hui population is higher than the overall Chinese population. In this study, we investigated whether COX-2-765G>C polymorphism, an extensively studied polymorphism, contributes to gastric cancer and its precursor lesions (GPL) in the Chinese Hui ethnic group.
  
  
  METHODS
  COX-2-765G>C polymorphism was determined by pyrosequencing in 100 gastric cancer cases, 102 gastric cancerand its precursor lesions cases and 105 controls. Data were statistically analyzed using Chi-square tests and logistic regression models.
  
  
  RESULTS
  Among the Chinese Hui ethnic group COX-2 -765 C allele carriers were at increased risk for gastric cancer (OR=1.977, 95%CI=1.104-3.541). We also found an interaction between COX-2 -765 C carriers and Helicobacter pylori infection and eating pickled vegetables.
  
  
  CONCLUSIONS
  Our findings suggest a multi-step process of gene-environment interaction contributes to gastric carcinogenesis.
authors.affiliation: Second Hospital of Lanzhou University, Lanzhou, China E-mail : liym@lzu.edu.cn.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Xiao-Fan
authors.initials: XF
authors.lastname: Tang
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Li
mesh_terms: D001483:Base Sequence; D063646:Carcinogenesis / Q000235:genetics*; D002681:China; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004032:Diet; D005006:Ethnicity / Q000235:genetics; D005247:Feeding Behavior; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011230:Precancerous Conditions / Q000235:genetics; D012306:Risk; D017422:Sequence Analysis, DNA; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000401:mortality; D011795:Surveys and Questionnaires
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human