title: Boronic acid-based enzyme inhibitors: a review of recent progress.
abstract: Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma, various boronic acid compounds have been developed as enzyme inhibitors. This paper reviewed the progress of boronic acid-based inhibitors against enzymes including proteasome, serine protease, HDACs and other enzymes in the past decade.
authors.forename: H
authors.initials: H
authors.lastname: Fu
authors.forename: H
authors.initials: H
authors.lastname: Fang
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, 18877 Jingshi Rd., Ji'nan, Shandong 250062, China. zhongyuwu@gmail.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001897:Boronic Acids / Q000494:pharmacology / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007935:Leucine-tRNA Ligase / Q000037:antagonists & inhibitors; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D010727:Phosphoric Diester Hydrolases; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000099189:Lysophospholipase D
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D056572:Histone Deacetylase Inhibitors; D007935:Leucine-tRNA Ligase; D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases; D011480:Protease Inhibitors; D000099189:Lysophospholipase D