title: Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis.
abstract: A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK. martin.smith@chem.ox.ac.uk.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Knipe
authors.forename: Martin D
authors.initials: MD
authors.lastname: Smith
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D055664:Electrochemical Techniques; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000814:Aniline Compounds; C406944:BINOL, naphthol; D058116:Lewis Acids; D009284:Naphthols; D015363:Quinolones; D003300:Copper