title: CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis.
abstract: In higher plants, cell cycle activation in the meristems at germination is essential for the initiation of post-embryonic development. We previously identified the signaling pathways of homeobox transcription factor STIMPY and metabolic sugars as two interacting branches of the regulatory network that is responsible for activating meristematic tissue proliferation in Arabidopsis. In this study, we found that CYCP2;1 is both a direct target of STIMPY transcriptional activation and an early responder to sugar signals. Genetic and molecular studies show that CYCP2;1 physically interacts with three of the five mitotic CDKs in Arabidopsis, and is required for the G2 to M transition during meristem activation. Taken together, our results suggest that CYCP2;1 acts as a permissive control of cell cycle progression during seedling establishment by directly linking genetic control and nutritional cues with the activity of the core cell cycle machinery.
authors.affiliation: Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Peng
authors.affiliation: Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Skylar
authors.affiliation: Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Chang
authors.affiliation: Laboratory of Cell Cycles of Algae, Centre Algatech, Institute of Microbiology, Academy of Sciences of the Czech Republic, Třeboň, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Bisova
authors.affiliation: Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: xuelinwu@usc.edu.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Wu
mesh_terms: D017360:Arabidopsis / Q000196:embryology*; D029681:Arabidopsis Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division / Q000235:genetics*; D049109:Cell Proliferation; D018844:Cyclin-Dependent Kinases / Q000096:biosynthesis; D016213:Cyclins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D018398:Homeodomain Proteins / Q000235:genetics; D018519:Meristem / Q000166:cytology / Q000196:embryology*; D036226:Seedlings / Q000235:genetics; D013395:Sucrose / Q000494:pharmacology; D015533:Transcriptional Activation
chemical_list: D029681:Arabidopsis Proteins; C000592846:CYCP2;1 protein, Arabidopsis; D016213:Cyclins; C478558:D-type cyclin CDCD4.1, Arabidopsis; D018398:Homeodomain Proteins; C500834:STIMPY protein, Arabidopsis; D013395:Sucrose; C518664:CDKB2;1 protein, Arabidopsis; D018844:Cyclin-Dependent Kinases
keywords: Arabidopsis; CYCP2;1; Cell division; Meristem; STIP; Sugar signal