title: Urinary nerve growth factor in patients with detrusor overactivity.
abstract: BACKGROUND
  Detrusor overactivity (DO) is one of the most frequent bladder dysfunctions in children up to the age of 18. Nowadays, the only way to confirm DO is by urodynamic investigation, which is an invasive procedure. Among the many mediators influencing bladder function, nerve growth factor (NGF) plays an important role. The present study was designed to measure urinary NGF (uNGF) levels in patients with DO diagnosed by urodynamic study in comparison with healthy controls.
  
  
  METHODS
  The investigation was conducted on 44 children, divided into two groups (24 patients with DO, 20 healthy children). Uroflowmetry was performed in all enrolled to the study and cystometry only to patients. uNGF levels were estimated in both studied groups.
  
  
  RESULTS
  The median uNGF level in patients with DO before treatment was higher compared with healthy controls. There were no differences between uNGF levels in patients after anticholinergic treatment and the controls. We found differences in uroflowmetry parameters between the reference group and the patients. We found correlations between uroflowmetry parameters and uNGF/cr. level.
  
  
  CONCLUSIONS
  1. The uNGF level could be used for detecting DO in children and adolescents. 2. Measuring uNGF level is a simple, noninvasive procedure and very useful for choosing therapy in patients with DO in various clinical conditions.
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Bialystok, 17 Waszyngtona Street, 15-274, Bialystok, Poland. agatakozerska@poczta.onet.pl.
authors.forename: A
authors.initials: A
authors.lastname: Korzeniecka-Kozerska
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Bialystok, 17 Waszyngtona Street, 15-274, Bialystok, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Wasilewska
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020932:Nerve Growth Factor / Q000652:urine*; D053201:Urinary Bladder, Overactive / Q000503:physiopathology*; D014563:Urodynamics
chemical_list: C502240:NGF protein, human; D020932:Nerve Growth Factor
keywords: Detrusor overactivity; Nerve growth factor; Overactive bladder; Urodynamics