title: Glutathione S-transferase M1 null genotype meta-analysis on gastric cancer risk.
abstract: BACKGROUND
  Glutathione S-transferases (GSTs) have proved to be involved in the detoxifying several carcinogens and may play an important role in carcinogenesis of cancer. Previous studies on the association between Glutathione S-transferase M1 (GSTM1) polymorphism and gastric cancer (GC) risk reported inconclusive results. To get a precise result, we conducted this present meta-analysis through pooling all eligible studies.
  
  
  METHODS
  A comprehensive databases of Pubmed, Embase, Web of Science, and the Chinese Biomedical Database (CBM) were searched for case-control studies investigating the association between GSTM1 null genotype and GC risk. Odds ratios (OR) and 95% confidence intervals (95% CI) were used to assess this possible association. A χ2-based Q-test was used to examine the heterogeneity assumption. Begg's and Egger's test were used to examine the potential publication bias. The leave-one-out sensitivity analysis was conducted to determine whether our assumptions or decisions have a major effect on the results of present work. Statistical analyses were performed with the software program STATA 12.0.
  
  
  RESULTS
  A total of 47 eligible case-control studies were identified, including 6,678 cases and 12,912 controls. Our analyses suggested that GSTM1 null genotype was significantly associated with increased risk of GC (OR=1.186, 95% CI=1.057-1.329, Pheterogenetiy=0.000, P=0.004). Significant association was also found in Asians (OR=1.269, 95% CI=1.106-1.455, Pheterogenetiy=0.002, P=0.001). However, GSTM1 null genotype was not contributed to GC risk in Caucasians (OR=1.115, 95% CI=0.937-1.326, Pheterogenetiy=0.000, P=0.222). In the subgroup analysis stratified by sources of controls, significant association was detected in hospital-based studies (OR=1.355, 95% CI=1.179-1.557, Pheterogenetiy=0.001, P=0.000), while there was no significant association detected in population-based studies (OR=1.017, 95% CI=0.862-1.200, Pheterogenetiy=0.000, P=0.840).
  
  
  CONCLUSIONS
  This meta-analysis showed the evidence that GSTM1 null genotype contributed to the development of GC.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1644180505119533.
authors.forename: Xianhong
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Gastroenterology, Affiliated to the Fourth Hospital of Harbin Medical University, Harbin 150001, China. yongliu_sy@126.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Bona
authors.initials: B
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D044465:White People / Q000235:genetics
chemical_list: D005982:Glutathione Transferase