title: Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation.
abstract: BACKGROUND
  Liquisolid systems are modern formulations used to increase the bioavailability of poorly water-soluble drugs. Their preparation is based on the sorption of a drug in liquid state onto a carrier with a high adsorption capacity. The carrier particles are subsequently coated with material having a large surface area to form free-flowing powder. The main principle of bioavailability increasing is based on the presence of the dissolved drug, which is ready for immediate absorption in GI tract.
  
  
  OBJECTIVE
  Determination of capability of aluminometasilicate carrier Neusilin® US2 to adsorb different solvents.
  
  
  METHODS
  The maximum amounts of polyethylene glycol 200 (PEG 200), polyethylene glycol 400 and propylene glycol (PG), which can be sorbed by Neusilin® US2, while maintaining an acceptable flowability of the powder mixture, were evaluated using determination of the flowable liquid retention potential.
  
  
  CONCLUSIONS
  From the evaluation of liquisolid powder mixtures, it could be observed that 1 g of Neusilin® US2 can retain up to 1.00 g of PG, 1.16 g of polyethylene glycol 400 and 1.48 g of PEG 200, while maintaining acceptable flowing properties.
  
  
  CONCLUSIONS
  Large specific surface area in combination with a high absorption capacity makes Neusilin® US2 suitable carrier for liquisolid system preparation.
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Vraníková
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Vetchý
keywords: Aluminometasilicate carrier; Neusilin, sorption; bioavailability increasing; flowable liquid retention potential; liquisolid systems