title: Renalase gene polymorphism in patients after renal allograft transplantation.
abstract: OBJECTIVE
  Renalase is a recently discovered protein, which is likely involved in regulation of blood pressure in humans and animals. Previous studies suggest that renalase reflects kidney functioning. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has been described. In this study we examined the association between (Glu37Asp) polymorphism (rs2296545) in renalase gene and kidney allograft function.
  
  
  METHODS
  The study enrolled 270 Caucasian kidney allograft recipients. SNP within the renalase was genotyped using TaqMan genotyping assays.
  
  
  RESULTS
  There were no statistically significant associations between renalase gene rs2296545 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction as well as creatinine serum concentrations and blood pressure values after transplantation.
  
  
  CONCLUSIONS
  The results of this study suggest, that renalase gene rs2296545 polymorphism is not important factor determining renal allograft function.
authors.affiliation: Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
authors.forename: Maria
authors.initials: M
authors.lastname: Serdynska
authors.forename: Ewa
authors.initials: E
authors.lastname: Dabrowska-Zamojcin
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Leszek
authors.initials: L
authors.lastname: Domanski
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D000328:Adult; D064591:Allografts; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000097:blood; D005260:Female; D005838:Genotype; D006084:Graft Rejection / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies; D044465:White People / Q000235:genetics
chemical_list: D003404:Creatinine; D008995:Monoamine Oxidase; C521557:renalase