title: Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.
abstract: BACKGROUND
  Glucova Active Tablet is a proprietary Ayurvedic formulation with ingredients reported for anti-hyperglycemic, anti-hyperlipidemic activity and antioxidant properties.
  
  
  OBJECTIVE
  Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.
  
  
  METHODS
  Experimental Type I diabetes was induced in 24 albino rats with intra-peritoneal injection of streptozotocin (50 mg/kg). Type II diabetes was induced in 18 albino rats by intra-peritoneal injection of streptozotocin (35 mg/kg) along with high fat diet. The rats were divided in 5 groups for Type I model and 4 groups for Type II model. Normal control group was kept common for both experimental models. Glucova Active Tablet (108 mg/kg) treatment was provided for 28 days twice daily orally. Fasting blood glucose level, serum lipid profile and liver anti-oxidant parameters like superoxide dismutase and reduced glutathione was carried out in both experimental models. Pancreas histopathology was also done. Statistical analysis were done by 'analysis of variance' test followed by post hoc Tukey's test, with significant level of P < 0.05.
  
  
  CONCLUSIONS
  Glucova Active Tablet showed significant effect on fasting blood glucose level. It also showed significant alteration in lipid profile and antioxidant parameters. Histopathology study revealed restoration of beta cells in pancreas in Glucova Active Tablet treated group.
  
  
  CONCLUSIONS
  Finding of this study concludes that Glucova Active Tablet has shown promising anti-diabetic activity in Type I and Type II diabetic rats. It was also found showing good anti-hyperlipidemic activity and anti-oxidant property.
authors.affiliation: Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., G.I.D.C., Makarpura, India.
authors.forename: Hardik
authors.initials: H
authors.lastname: Soni
authors.affiliation: Department of Pharmacology, Baroda College of Pharmacy, Gujarat Technological University, Waghodia, Vadodara, Gujarat, India.
authors.forename: Sejal
authors.initials: S
authors.lastname: Patel
authors.affiliation: Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., G.I.D.C., Makarpura, India.
authors.forename: Ghanshyam
authors.initials: G
authors.lastname: Patel
authors.affiliation: Department of Pharmacology, Baroda College of Pharmacy, Gujarat Technological University, Waghodia, Vadodara, Gujarat, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Paranjape
keywords: Anti-hyperlipidemic; Glucova Active Tablet; Type I and Type II diabetic model; anti-oxidant