title: The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population.
abstract: The PI3K signaling pathway plays an important role in the development of colorectal cancer (CRC) and other neoplasm. Somatic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mutations and deletions or epigenetic silencing have been observed in multiple tumor types including CRC. To assess the association of PTEN polymorphisms and lifestyle habits with CRC risk in Chinese population, we carried out a case-control study which included 545 cases and 522 controls. In the present study, we genotyped eight single-nucleotide polymorphisms (SNPs) in PTEN and found that rs11202607 was associated with increased CRC risk (odds ratio (OR) = 1.40, 95 % confidence interval (CI) = 1.04-1.90). Stratification analysis by lifestyle habits showed a stronger association between rs11202607 and CRC risk among never tea drinkers than that among tea-drinkers (OR = 2.04, 95 % CI 1.29-3.22), and significant additive interaction between rs10490920 and tea drinking status was observed. Our study provided the evidence of an association between PTEN polymorphisms and the risk of CRC and significant additive interaction between PTEN polymorphism and tea drinking. Studies with larger sample size and further investigations into the mechanism are warranted to clarify the role of PTEN in colorectal carcinogenesis and the association between PTEN genetic variations, environment exposure, and CRC risk.
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Jing
authors.forename: Yingying
authors.initials: Y
authors.lastname: Mao
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Li
authors.forename: Shaofang
authors.initials: S
authors.lastname: Cai
authors.forename: Qilong
authors.initials: Q
authors.lastname: Li
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Ma
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Jin
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005247:Feeding Behavior; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking; D013662:Tea
chemical_list: D013662:Tea; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human