title: The genomic landscape underlying phenotypic integrity in the face of gene flow in crows.
abstract: The importance, extent, and mode of interspecific gene flow for the evolution of species has long been debated. Characterization of genomic differentiation in a classic example of hybridization between all-black carrion crows and gray-coated hooded crows identified genome-wide introgression extending far beyond the morphological hybrid zone. Gene expression divergence was concentrated in pigmentation genes expressed in gray versus black feather follicles. Only a small number of narrow genomic islands exhibited resistance to gene flow. One prominent genomic region (<2 megabases) harbored 81 of all 82 fixed differences (of 8.4 million single-nucleotide polymorphisms in total) linking genes involved in pigmentation and in visual perception-a genomic signal reflecting color-mediated prezygotic isolation. Thus, localized genomic selection can cause marked heterogeneity in introgression landscapes while maintaining phenotypic divergence.
authors.affiliation: Science for Life Laboratory and Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden.
authors.forename: J W
authors.initials: JW
authors.lastname: Poelstra
authors.affiliation: Science for Life Laboratory and Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Vijay
authors.affiliation: Science for Life Laboratory and Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden.
authors.forename: C M
authors.initials: CM
authors.lastname: Bossu
authors.affiliation: Bioinformatics Infrastructure for Life Sciences, Uppsala University, 75124 Uppsala, Sweden. Science for Life Laboratory and Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Lantz
authors.affiliation: Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Ryll
authors.affiliation: Max Planck Institute for Ornithology, 78315 Radolfzell, Germany. Department of Biology, University of Konstanz, 78464 Konstanz, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Müller
authors.affiliation: Departamento de Ciencias Agro-Forestales, Campus La Yutera, Universidad de Valladolid, 34004 Palencia, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Baglione
authors.affiliation: Science for Life Laboratory and Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Unneberg
authors.affiliation: Max Planck Institute for Ornithology, 78315 Radolfzell, Germany. Department of Biology, University of Konstanz, 78464 Konstanz, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Wikelski
authors.affiliation: Science for Life Laboratory and Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
authors.forename: M G
authors.initials: MG
authors.lastname: Grabherr
authors.affiliation: Science for Life Laboratory and Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden. jochen.wolf@ebc.uu.se.
authors.forename: J B W
authors.initials: JB
authors.lastname: Wolf
mesh_terms: D000818:Animals; D046368:Crows / Q000235:genetics*; D019143:Evolution, Molecular; D005241:Feathers / Q000166:cytology* / Q000201:enzymology; D051456:Gene Flow; D014644:Genetic Variation; D023281:Genomics; D006824:Hybridization, Genetic; D008544:Melanocytes / Q000201:enzymology*; D010641:Phenotype; D010858:Pigmentation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012641:Selection, Genetic