title: Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: a prospective study.
abstract: OBJECTIVE
  To investigate the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis.
  
  
  METHODS
  Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment. During HIFU treatment, 80 units of oxytocin was added in 500ml of 0.9% normal saline running at the rate of 2ml/min (0.32U/min) in the oxytocin group, while 0.9% normal saline was used in the control group. Both patients and HIFU operators were blinded to oxytocin or saline application. Treatment results, adverse effects were compared.
  
  
  RESULTS
  When using oxytocin, the non-perfused volume (NPV) ratio was 80.7±11.6%, the energy-efficiency factor (EEF) was 8.1±9.9J/mm(3), and the sonication time required to ablate 1cm(3) was 30.0±36.0s/cm(3). When not using oxytocin, the non-perfused volume ratio was 70.8±16.7%, the EEF was 15.8±19.6J/mm(3), and the sonication time required to ablate 1cm(3) was 58.2±72.7S/cm(3). Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1cm(3) between the two groups was observed. No oxytocin related adverse effects occurred.
  
  
  CONCLUSIONS
  Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU, safely enhance the treatment efficiency.
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zou
authors.affiliation: Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China.
authors.forename: Cai
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000, PR China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099, PR China.
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China; Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China; Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099, PR China.
authors.forename: Ruitao
authors.initials: R
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China. Electronic address: lianwzhang@yahoo.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
mesh_terms: D062788:Adenomyosis / Q000601:surgery*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005682:Gadolinium; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014599:Uterus / Q000473:pathology
chemical_list: D010120:Oxytocics; D010121:Oxytocin; D005682:Gadolinium
keywords: Adenomyosis; High intensity focused ultrasound (HIFU); Oxytocin