title: A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer.
abstract: An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.
authors.affiliation: Department of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, P. R. China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Miao
authors.forename: Gang
authors.initials: G
authors.lastname: Ren
authors.forename: Yingding
authors.initials: Y
authors.lastname: Xu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002460:Cell Line; D002614:Chelating Agents / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D018796:Immunoconjugates; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D061848:Optical Imaging / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D010053:Ovary / Q000473:pathology*; D011073:Polyamines / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D002614:Chelating Agents; D050091:Dendrimers; D005456:Fluorescent Dyes; D018796:Immunoconjugates; C531249:Poly(amidoamine); D011073:Polyamines