title: Stiff-person syndrome: case series.
abstract: Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases of patients with classical SPS finally confirmed by high serum level of GAD antibodies. All of our patients respond favorably to gamma amino butyric acid-enhancing drugs and immunotherapies.
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul, Korea ; Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Korea.
authors.forename: Yu Jin
authors.initials: YJ
authors.lastname: Jung
authors.affiliation: Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Korea.
authors.forename: Han G
authors.initials: HG
authors.lastname: Jeong
authors.affiliation: Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ryul
authors.initials: R
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul, Korea ; Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Korea.
authors.forename: Han-Joon
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul, Korea ; Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Korea.
authors.forename: Beom S
authors.initials: BS
authors.lastname: Jeon
keywords: Autoimmune disease; Glutamic acid decarboxylase antibody; Stiff-person syndrome