title: Correspondence Between Aberrant Intrinsic Network Connectivity and Gray-Matter Volume in the Ventral Brain of Preterm Born Adults.
abstract: Widespread brain changes are present in preterm born infants, adolescents, and even adults. While neurobiological models of prematurity facilitate powerful explanations for the adverse effects of preterm birth on the developing brain at microscale, convincing linking principles at large-scale level to explain the widespread nature of brain changes are still missing. We investigated effects of preterm birth on the brain's large-scale intrinsic networks and their relation to brain structure in preterm born adults. In 95 preterm and 83 full-term born adults, structural and functional magnetic resonance imaging at-rest was used to analyze both voxel-based morphometry and spatial patterns of functional connectivity in ongoing blood oxygenation level-dependent activity. Differences in intrinsic functional connectivity (iFC) were found in cortical and subcortical networks. Structural differences were located in subcortical, temporal, and cingulate areas. Critically, for preterm born adults, iFC-network differences were overlapping and correlating with aberrant regional gray-matter (GM) volume specifically in subcortical and temporal areas. Overlapping changes were predicted by prematurity and in particular by neonatal medical complications. These results provide evidence that preterm birth has long-lasting effects on functional connectivity of intrinsic networks, and these changes are specifically related to structural alterations in ventral brain GM.
authors.affiliation: Department of Neuroradiology, TUM-NIC Neuroimaging Center, Technische Universität München, München, Germany.
authors.forename: Josef G
authors.initials: JG
authors.lastname: Bäuml
authors.affiliation: Functional Neuroimaging Group, Department of Radiology and Department of Neonatology, University Hospital Bonn, Bonn, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Daamen
authors.affiliation: Department of Neuroradiology, TUM-NIC Neuroimaging Center, Technische Universität München, München, Germany.
authors.forename: Chun
authors.initials: C
authors.lastname: Meng
authors.affiliation: Department of Neuroradiology, TUM-NIC Neuroimaging Center, Technische Universität München, München, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Neitzel
authors.affiliation: Functional Neuroimaging Group, Department of Radiology and.
authors.forename: Lukas
authors.initials: L
authors.lastname: Scheef
authors.affiliation: Department of Psychology and Department of Developmental Psychology, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Jaekel
authors.affiliation: Department of Neonatology, University Hospital Bonn, Bonn, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Busch
authors.affiliation: Department of Psychology and.
authors.forename: Nicole
authors.initials: N
authors.lastname: Baumann
authors.affiliation: Department of Neonatology, University Hospital Bonn, Bonn, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bartmann
authors.affiliation: Department of Psychology and Warwick Medical School, University of Warwick, Coventry, UK.
authors.forename: Dieter
authors.initials: D
authors.lastname: Wolke
authors.affiliation: Functional Neuroimaging Group, Department of Radiology and.
authors.forename: Henning
authors.initials: H
authors.lastname: Boecker
authors.affiliation: Department of Neuroradiology, TUM-NIC Neuroimaging Center, Technische Universität München, München, Germany.
authors.forename: Afra M
authors.initials: AM
authors.lastname: Wohlschläger
authors.affiliation: Department of Neuroradiology, Department of Psychiatry, Klinikum rechts der Isar and TUM-NIC Neuroimaging Center, Technische Universität München, München, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000254:growth & development* / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D005260:Female; D066128:Gray Matter / Q000254:growth & development / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology*; D047928:Premature Birth / Q000473:pathology*; D055815:Young Adult
keywords: brain structure; intrinsic network; preterm birth; preterm born adults; structure–function relationship