title: Molecular epidemiology of OXA-48-producing Klebsiella pneumoniae in France.
abstract: We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST database. Most of the OXA-48-Kp isolates also produced CTX-M-15 and remained susceptible to imipenem and meropenem. The isolates were distributed into 20 STs, of which five were dominant (ST15, ST101, ST147, ST395 and ST405). All the OXA-48-Kp clustered in the major clade of K. pneumoniae KpI.
authors.affiliation: Service d'Hygiène Hospitalière, UMR 6249 Chrono-environnement, Centre Hospitalier Régional Universitaire, Université de Franche-Comté, Besançon, France.
authors.forename: E
authors.initials: E
authors.lastname: Liapis
authors.forename: A
authors.initials: A
authors.lastname: Pantel
authors.forename: J
authors.initials: J
authors.lastname: Robert
authors.forename: M-H
authors.initials: MH
authors.lastname: Nicolas-Chanoine
authors.forename: L
authors.initials: L
authors.lastname: Cavalié
authors.forename: N
authors.initials: N
authors.lastname: van der Mee-Marquet
authors.forename: C
authors.initials: C
authors.lastname: de Champs
authors.forename: N
authors.initials: N
authors.lastname: Aissa
authors.forename: C
authors.initials: C
authors.lastname: Eloy
authors.forename: V
authors.initials: V
authors.lastname: Blanc
authors.forename: C
authors.initials: C
authors.lastname: Guyeux
authors.forename: D
authors.initials: D
authors.lastname: Hocquet
authors.forename: J-P
authors.initials: JP
authors.lastname: Lavigne
authors.forename: X
authors.initials: X
authors.lastname: Bertrand
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016521:Electrophoresis, Gel, Pulsed-Field; D005602:France / Q000453:epidemiology; D005838:Genotype; D006761:Hospitals; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D000077731:Meropenem; D017720:Molecular Epidemiology; D058885:Multilocus Sequence Typing; D013845:Thienamycins / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; C108449:oxacillinase; D000077731:Meropenem
keywords: Multidrug resistance; multilocus sequence typing; phylogenetic analysis