title: Genome-wide association analysis identifies six new loci associated with forced vital capacity.
abstract: Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
authors.affiliation: 1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Health Care Inspectorate, The Hague, the Netherlands. [3].
authors.forename: Daan W
authors.initials: DW
authors.lastname: Loth
authors.affiliation: 1] Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK. [3].
authors.forename: María
authors.initials: M
authors.lastname: Soler Artigas
authors.affiliation: 1] Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, Washington, USA. [2] Department of Medicine, University of Washington, Seattle, Washington, USA. [3].
authors.forename: Sina A
authors.initials: SA
authors.lastname: Gharib
authors.affiliation: 1] Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK. [3].
authors.forename: Louise V
authors.initials: LV
authors.lastname: Wain
authors.affiliation: 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [3].
authors.forename: Nora
authors.initials: N
authors.lastname: Franceschini
authors.affiliation: 1] Department of Internal Medicine B-Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany. [2].
authors.forename: Beate
authors.initials: B
authors.lastname: Koch
authors.affiliation: 1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [2].
authors.forename: Tess D
authors.initials: TD
authors.lastname: Pottinger
authors.affiliation: 1] Iceland Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland. [3].
authors.forename: Albert Vernon
authors.initials: AV
authors.lastname: Smith
authors.affiliation: 1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [2].
authors.forename: Qing
authors.initials: Q
authors.lastname: Duan
authors.affiliation: 1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: Oldmeadow
authors.affiliation: Institute of Health and Environment, Seoul National University, Seoul, South Korea.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.affiliation: Division of Population Health Sciences and Education, St George's, University of London, London, UK.
authors.forename: David P
authors.initials: DP
authors.lastname: Strachan
authors.affiliation: 1] Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Western Australia, Australia. [2] School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia. [3] Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.
authors.forename: Alan L
authors.initials: AL
authors.lastname: James
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Huffman
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Veronique
authors.initials: V
authors.lastname: Vitart
authors.affiliation: 1] Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK. [2] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
authors.forename: Adaikalavan
authors.initials: A
authors.lastname: Ramasamy
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.affiliation: 1] Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland. [2] National Institute for Health and Welfare (THL), Helsinki, Finland. [3] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Kaprio
authors.affiliation: Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Xin-Qun
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Holly
authors.initials: H
authors.lastname: Trochet
authors.affiliation: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Flexeder
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Albrecht
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.
authors.forename: Lorna M
authors.identifier: 0000000202419783
authors.initials: LM
authors.lastname: Lopez
authors.affiliation: 1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Kim
authors.initials: K
authors.lastname: de Jong
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Bharat
authors.initials: B
authors.lastname: Thyagarajan
authors.affiliation: Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
authors.forename: Alexessander Couto
authors.initials: AC
authors.lastname: Alves
authors.affiliation: 1] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [2] Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Stefan
authors.identifier: 0000000250569137
authors.initials: S
authors.lastname: Enroth
authors.affiliation: 1] Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway. [2] Department of Clinical Sciences, University of Bergen, Bergen, Norway.
authors.forename: Ernst
authors.initials: E
authors.lastname: Omenaas
authors.affiliation: Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Joshi
authors.affiliation: 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Tove
authors.initials: T
authors.lastname: Fall
authors.affiliation: Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.
authors.forename: Ana
authors.identifier: 0000000337718537
authors.initials: A
authors.lastname: Viñuela
authors.affiliation: Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.affiliation: 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Laura R
authors.initials: LR
authors.lastname: Loehr
authors.affiliation: 1] Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA. [2] Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.affiliation: Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
authors.forename: Guo
authors.initials: G
authors.lastname: Li
authors.affiliation: Precision Medicine, Pfizer Global Research and Development, Cambridge, Massachusetts, USA.
authors.forename: Jemma B
authors.initials: JB
authors.lastname: Wilk
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Tang
authors.affiliation: 1] Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA. [2] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Ani
authors.initials: A
authors.lastname: Manichaikul
authors.affiliation: 1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: Lies
authors.initials: L
authors.lastname: Lahousse
authors.affiliation: Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.affiliation: Division of Population Health Sciences and Education, St George's, University of London, London, UK.
authors.forename: Alicja R
authors.initials: AR
authors.lastname: Rudnicka
authors.affiliation: PathWest Laboratory Medicine Washington, Nedlands, Western Australia, Australia.
authors.forename: Jennie
authors.initials: J
authors.lastname: Hui
authors.affiliation: 1] Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA. [2] Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Statistics, University of Auckland, Auckland, New Zealand.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lumley
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Alan F
authors.initials: AF
authors.lastname: Wright
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Hastie
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Campbell
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.affiliation: 1] Centre Hospitalier Universitaire de Grenoble, Grenoble, France. [2] INSERM U823, Institut Albert Bonniot, Grenoble, France. [3] Université Joseph Fourier, Grenoble, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pin
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Scott
authors.affiliation: 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. [3] Division of Internal Medicine, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Kirsi H
authors.initials: KH
authors.lastname: Pietiläinen
authors.affiliation: 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland.
authors.forename: Ida
authors.initials: I
authors.lastname: Surakka
authors.affiliation: Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Holliday
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Schulz
authors.affiliation: 1] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Comprehensive Pneumology Center Munich (CPC-M), member of the German Center for Lung Research, Munich, Germany.
authors.forename: Joachim
authors.identifier: 0000000296201629
authors.initials: J
authors.lastname: Heinrich
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Department of Psychology, University of Edinburgh, Edinburgh, UK. [3] Medical Genetics Section, Centre for Genomics and Experimental Medicine, MRC IGMM, University of Edinburgh, Edinburgh, UK. [4] MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.
authors.forename: Gail
authors.initials: G
authors.lastname: Davies
authors.affiliation: 1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Vonk
authors.affiliation: Department of Statistical Genomics, Washington University, St. Louis, Missouri, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Wojczynski
authors.affiliation: 1] National Institute for Health and Welfare, Oulu, Finland. [2] Department of Clinical Sciences/Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Oulu, Finland.
authors.forename: Anneli
authors.initials: A
authors.lastname: Pouta
authors.affiliation: 1] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [2] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [3] Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
authors.forename: Asa
authors.identifier: 0000000229154498
authors.initials: A
authors.lastname: Johansson
authors.affiliation: Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Wild
authors.affiliation: 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. [3] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
authors.forename: Erik
authors.initials: E
authors.lastname: Ingelsson
authors.affiliation: 1] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.affiliation: Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.
authors.forename: Pirro G
authors.initials: PG
authors.lastname: Hysi
authors.affiliation: Iceland Heart Association, Kopavogur, Iceland.
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.affiliation: School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Alanna C
authors.initials: AC
authors.lastname: Morrison
authors.affiliation: 1] Biomedical Research Institute, Harbor-University of California, Los Angeles (UCLA) Medical Center, Torrance, California, USA. [2] Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: 1] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Dirkje S
authors.initials: DS
authors.lastname: Postma
authors.affiliation: Tougaloo College, Jackson, Mississippi, USA.
authors.forename: Wendy B
authors.initials: WB
authors.lastname: White
authors.affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.affiliation: 1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: 1] Iceland Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland.
authors.forename: Thor
authors.initials: T
authors.lastname: Aspelund
authors.affiliation: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: David
authors.initials: D
authors.lastname: Couper
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Smith
authors.affiliation: 1] Department of Medicine, University of Washington, Seattle, Washington, USA. [2] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. [3] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [4] Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.affiliation: Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Kurt
authors.initials: K
authors.lastname: Lohman
authors.affiliation: 1] Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA. [2] Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Esteban G
authors.initials: EG
authors.lastname: Burchard
authors.affiliation: 1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [3] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Garcia
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
authors.forename: Bonnie R
authors.initials: BR
authors.lastname: Joubert
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Wendy L
authors.initials: WL
authors.lastname: McArdle
authors.affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
authors.forename: A Bill
authors.initials: AB
authors.lastname: Musk
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Nadia
authors.initials: N
authors.lastname: Hansel
authors.affiliation: 1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [3] Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA.
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
authors.affiliation: 1] Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland. [2] Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.
authors.forename: Lina
authors.initials: L
authors.lastname: Zgaga
authors.affiliation: 1] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
authors.forename: Joyce B J
authors.initials: JB
authors.lastname: van Meurs
authors.affiliation: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
authors.forename: Pau
authors.initials: P
authors.lastname: Navarro
authors.affiliation: Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: Igor
authors.identifier: 0000000169936884
authors.initials: I
authors.lastname: Rudan
authors.affiliation: 1] Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. [2] Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Yeon-Mok
authors.initials: YM
authors.lastname: Oh
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Redline
authors.affiliation: 1] Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK. [2] MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Jarvis
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Jing Hua
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
authors.forename: Taina
authors.initials: T
authors.lastname: Rantanen
authors.affiliation: 1] Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA. [2] National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
authors.forename: George T
authors.initials: GT
authors.lastname: O'Connor
authors.affiliation: 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland. [3] Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Samuli
authors.initials: S
authors.lastname: Ripatti
authors.affiliation: 1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
authors.affiliation: 1] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians Universität, Munich, Germany. [3] Institute of General Practice, University Hospital Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Karrasch
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.affiliation: Research Computing Division, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Gaddis
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
authors.forename: John M
authors.initials: JM
authors.lastname: Starr
authors.affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
authors.forename: Cisca
authors.initials: C
authors.lastname: Wijmenga
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Minster
authors.affiliation: 1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [2] Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Lederer
authors.affiliation: 1] Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland. [2] Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
authors.forename: Juha
authors.initials: J
authors.lastname: Pekkanen
authors.affiliation: 1] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [2] Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Gyllensten
authors.affiliation: Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Morris
authors.affiliation: Department of Internal Medicine B-Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Gläser
authors.affiliation: Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.
authors.forename: Christopher J
authors.identifier: 0000000232272620
authors.initials: CJ
authors.lastname: Hammond
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Burkart
authors.affiliation: PathWest Laboratory Medicine Washington, Nedlands, Western Australia, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Beilby
authors.affiliation: Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.affiliation: 1] Iceland Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland.
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.affiliation: 1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2] Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.
authors.forename: Dana B
authors.initials: DB
authors.lastname: Hancock
authors.affiliation: Florida International University, Miami, Florida, USA.
authors.forename: O Dale
authors.initials: OD
authors.lastname: Williams
authors.affiliation: Department of Public Health, Medical School, University of Split, Split, Croatia.
authors.forename: Ozren
authors.initials: O
authors.lastname: Polasek
authors.affiliation: Department of Medical Biology, Medical School, University of Split, Split, Croatia.
authors.forename: Tatijana
authors.initials: T
authors.lastname: Zemunik
authors.affiliation: Department of Public Health, Medical School, University of Split, Split, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Kolcic
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
authors.forename: Marcy F
authors.initials: MF
authors.lastname: Petrini
authors.affiliation: Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), Munich, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Wjst
authors.affiliation: 1] Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea. [2] Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Kim
authors.affiliation: Medical Genetics Section, Centre for Genomics and Experimental Medicine, MRC IGMM, University of Edinburgh, Edinburgh, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Porteous
authors.affiliation: A collaboration between the University Medical Schools and National Health Service (NHS) in Aberdeen, Dundee, Edinburgh and Glasgow, UK.
authors.forename: Generation
authors.initials: G
authors.lastname: Scotland
authors.affiliation: Medical Research Institute, University of Dundee, Dundee, UK.
authors.forename: Blair H
authors.initials: BH
authors.lastname: Smith
authors.affiliation: Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
authors.forename: Anne
authors.initials: A
authors.lastname: Viljanen
authors.affiliation: National Institute for Health and Welfare (THL), Helsinki, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Heliövaara
authors.affiliation: 1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: John R
authors.initials: JR
authors.lastname: Attia
authors.affiliation: Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Sayers
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Regina
authors.initials: R
authors.lastname: Hampel
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.affiliation: 1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Deary
authors.affiliation: 1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: H Marike
authors.initials: HM
authors.lastname: Boezen
authors.affiliation: Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Newman
authors.affiliation: 1] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. [2] Institute of Health Sciences, University of Oulu, Oulu, Finland. [3] Biocenter Oulu, University of Oulu, Oulu, Finland. [4] Unit of Primary Care, Oulu University Hospital, Oulu, Finland. [5] Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
authors.forename: Marjo-Riitta
authors.initials: MR
authors.lastname: Jarvelin
authors.affiliation: Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: James F
authors.initials: JF
authors.lastname: Wilson
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Lind
authors.affiliation: 1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Health Care Inspectorate, The Hague, the Netherlands. [3] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [4] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Stricker
authors.affiliation: Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Alexander
authors.identifier: 000000028309094X
authors.initials: A
authors.lastname: Teumer
authors.affiliation: Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Spector
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Melén
authors.affiliation: 1] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
authors.forename: Marjolein J
authors.initials: MJ
authors.lastname: Peters
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Lange
authors.affiliation: 1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [2] Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: Ken R
authors.initials: KR
authors.lastname: Bracke
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
authors.forename: Fien M
authors.initials: FM
authors.lastname: Verhamme
authors.affiliation: 1] Institute of Health and Environment, Seoul National University, Seoul, South Korea. [2] Complex Disease and Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.
authors.forename: Joohon
authors.initials: J
authors.lastname: Sung
authors.affiliation: Department of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Pieter S
authors.initials: PS
authors.lastname: Hiemstra
authors.affiliation: 1] Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA. [2] Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cassano
authors.affiliation: 1] University of New Mexico Health Sciences Center School of Medicine, Albuquerque, New Mexico, USA. [2].
authors.forename: Akshay
authors.initials: A
authors.lastname: Sood
authors.affiliation: 1] Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK. [2].
authors.forename: Caroline
authors.initials: C
authors.lastname: Hayward
authors.affiliation: 1] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. [2] National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. [3].
authors.forename: Josée
authors.initials: J
authors.lastname: Dupuis
authors.affiliation: 1] Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK. [2].
authors.forename: Ian P
authors.initials: IP
authors.lastname: Hall
authors.affiliation: 1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. [3] Department of Respiratory Medicine, Erasmus MC, Rotterdam, the Netherlands. [4].
authors.forename: Guy G
authors.initials: GG
authors.lastname: Brusselle
authors.affiliation: 1] Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK. [3].
authors.forename: Martin D
authors.initials: MD
authors.lastname: Tobin
authors.affiliation: 1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2].
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: London
mesh_terms: D015331:Cohort Studies; D030541:Databases, Genetic; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D008171:Lung Diseases / Q000235:genetics* / Q000473:pathology; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D040641:Quantitative Trait Loci / Q000235:genetics; D012129:Respiratory Function Tests; D013147:Spirometry; D014797:Vital Capacity / Q000235:genetics*