title: Cognitive impairment among elderly individuals in Shanghai suburb, China: association of C-reactive protein and its interactions with other relevant factors.
abstract: OBJECTIVE
  To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors.
  
  
  METHODS
  Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in Shanghai suburb. The associations of serum CRP concentration and other relevant factors were examined with logistic regression analysis.
  
  
  RESULTS
  The mean CRP in patients with cognitive impairment was higher than that in controls (P < .001). The highest quartile of CRP (>4.77 mg/L), abdomen obesity, hypertriglyceridemia, and hyperglycemia was associated with cognitive impairment. Significant interactions were found between increased CRP and hypertriglyceridemia as well as between increased CRP and hyperglycemia on cognitive impairment; and the attributable proportion due to interaction was 82% (P < .0001) and 37% (P = .007), respectively.
  
  
  CONCLUSIONS
  Increased CRP was associated with cognitive impairment, and additive effects of increased CRP with hypertriglyceridemia and hyperglycemia on cognitive impairment were observed among elderly individuals.
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China School of Public Health, Shanghai Jiao Tong University, China.
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Chen
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China School of Public Health, Shanghai Jiao Tong University, China.
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Cui
authors.affiliation: School of Public Health, Shanghai Jiao Tong University, China Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Jiang
authors.affiliation: Center for Disease Control and Prevention of Qingpu District, Shanghai, China.
authors.forename: Rui-Fang
authors.initials: RF
authors.lastname: Xu
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China.
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China chen_sd@medmail.com.cn.
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
authors.affiliation: School of Public Health, Shanghai Jiao Tong University, China Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China qicheng@shsmu.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Cheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003072:Cognition Disorders / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000453:epidemiology; D012307:Risk Factors; D013383:Suburban Population / Q000706:statistics & numerical data; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein
keywords: C-reactive protein; cognitive impairment; interaction; risk factor