title: Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: a longitudinal study.
abstract: Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.
authors.affiliation: Don C Gnocchi Foundation ONLUS, Piazza Morandi 3, 20100, Milano, Italy rmancuso@dongnocchi.it.
authors.forename: R
authors.initials: R
authors.lastname: Mancuso
authors.affiliation: Laboratory of Neuroimmunology, IRCCS, C Mondino National Neurological Institute, Pavia, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Franciotta
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rovaris
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Caputo
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sala
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Hernis
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Agostini
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy.
authors.forename: Mg
authors.initials: M
authors.lastname: Calvo
authors.affiliation: Don C Gnocchi Foundation, ONLUS, Milan, Italy/University of Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000473:pathology; D000069442:Natalizumab; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007074:Immunoglobulin G; D000069442:Natalizumab; D043025:Oligoclonal Bands
keywords: Cerebrospinal fluid; intrathecal IgG; multiple sclerosis; natalizumab; oligoclonal bands