title: Rh-catalyzed sequential oxidative C-H and N-N bond activation: conversion of azines into isoquinolines with air at room temperature.
abstract: A rhodium-catalyzed sequential oxidative C-H annulation reaction between ketazines and internal alkynes has been developed via C-H and N-N bond activation with air as an external oxidant, which led to an efficient approach toward isoquinolines with high atom efficiency at rt. Utilizing the distinctive reactivity of this catalysis, both N-atoms of the azines could be efficiently incorporated to the desired isoquinolines under very robust and mild reaction conditions.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, China.
authors.forename: Wenjia
authors.initials: W
authors.lastname: Han
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhang
authors.forename: Guangxing
authors.initials: G
authors.lastname: Li
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang