title: [Doxycycline or how to create new with the old?].
abstract: Tetracyclines are broad-spectrum antibiotics that interfere with protein synthesis. They were first widely prescribed by dermatologists in the early 1950s in the treatment of acne. More recently, their biological actions on inflammation, proteolysis, angiogenesis, apoptosis, metal chelation, ionophoresis, and bone metabolism were studied. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade components of the extracellular matrix (ECM). MMPs have direct or indirect effects on the vascular endothelium and the vascular relaxation/contraction system. The therapeutic effects of tetracyclines and analogues were studied in rosacea, bullous dermatoses, neutrophilic diseases, pyoderma gangrenosum, sarcoidosis, aortic aneurysms, cancer metastasis, periodontitis and autoimmune diseases autoimmune diseases such as rheumatoid arthritis and scleroderma. In addition, downregulation of MMP using doxycycline could be beneficial in reducing vascular dysfunction mediated by MMPs and progressive damage of the vascular wall. We review the nonantibiotic properties of doxycycline and its potential clinical applications.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Shehwaro
authors.forename: Anne-Lyse
authors.initials: AL
authors.lastname: Langlois
authors.forename: Victor
authors.initials: V
authors.lastname: Gueutin
authors.forename: Marion
authors.initials: M
authors.lastname: Gauthier
authors.forename: Maud
authors.initials: M
authors.lastname: Casenave
authors.forename: Hassane
authors.initials: H
authors.lastname: Izzedine
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004318:Doxycycline / Q000494:pharmacology* / Q000627:therapeutic use; D058492:Drug Repositioning; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010510:Periodontal Diseases / Q000188:drug therapy; D012216:Rheumatic Diseases / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D004318:Doxycycline