title: [Endoscopic vacuum therapy of perforations and anastomotic insufficiency of the esophagus].
abstract: BACKGROUND
  The high morbidity and mortality of esophageal defects show that the clinical challenge in the treatment of this disease still remains. An innovative method which has been developed in recent years for esophageal leakage is endoscopic vacuum therapy.
  
  
  OBJECTIVE
  A retrospective analysis of all patients treated for esophageal perforation with endoscopic vacuum therapy in our department was carried out.
  
  
  METHODS
  From November 2006 to October 2013 a total of 35 patients were treated with this method and of these 21 had anastomotic leakage, 7 had iatrogenic perforation due to flexible or rigid endoscopy and 7 patients had esophageal defects of various other origins. Drainage systems with an open pore polyurethane tip were placed using a standard endoscope. The vacuum drainage may be positioned either in the esophageal lumen onto the defect or through the defect into the extraluminal wound cavity. The intraluminal or intracavitary vacuum drainage is connected to an electronically controlled vacuum device and a continuous negative pressure of 125 mmHg is maintained for several days. The esophageal lumen or wound cavity collapses around the drainage resulting in intraluminal evacuation and closure of the defect. Under endoscopic monitoring the vacuum system is changed regularly until stable secondary healing of the intracorporeal wound or closure of the transmural defect is achieved.
  
  
  RESULTS
  In 32 out of 35 patients (91.4 %) healing of defects was achieved after median treatment duration of 11 days (range 4-78 days). The postoperative anastomotic leakage healed in 20 out of 21 patients (95.2 %) after a median of 11 days (range 4-46 days) of therapy. The defects in the 7 patients who were treated for iatrogenic perforation all healed (100 %) after a median treatment time of 5 days (range 4-7 days). There was one case of a recurrent fistula 75 days after treatment. The 90-day mortality in this series of 35 patients was 5.7 %.
  
  
  CONCLUSIONS
  The results of this retrospective study emphasize the increasing importance of endoscopic vacuum therapy in the current literature as an endoscopic treatment method in the management of esophageal perforation and anastomotic leakage.
authors.affiliation: Klinik für Allgemein-, Viszeral-, Thorax-, und Gefäßchirurgie, Katholisches Marienkrankenhaus, GmbH, Alfredstr. 9, 22087, Hamburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Schorsch
authors.forename: C
authors.initials: C
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Loske
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D057868:Anastomotic Leak / Q000175:diagnosis / Q000601:surgery*; D004939:Esophageal Perforation / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004945:Esophagoscopy / Q000009:adverse effects; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D012189:Retrospective Studies; D013529:Surgical Wound Dehiscence / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*