title: Hypoxic regulation of metabolism offers new opportunities for anticancer therapy.
abstract: Cancer metabolism now appears to be optimized for growth of tumor cells by having an increased reliance on non-oxidative processes. However, in order to exploit these findings clinically, we must determine the specific pathways and components that cancer cells rely on, but are dispensable for normal cells. Because tumors have the added stress of hypoxia, the metabolic response to low oxygen may represent such a tumor-specific metabolic program.
authors.affiliation: Department of Radiation Oncology, Ohio State University Wexner Medical Center and OSU Comprehensive Cancer Center, Columbus, OH 43210, USA.
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Denko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015687:Cell Hypoxia / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D010100:Oxygen / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D010100:Oxygen
keywords: pyruvate dehydrogenase kinase; α-ketoglutarate dehydrogenase