title: Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp(3) carbon partners.
abstract: The first examples of a Pd-catalyzed carbonylation of aryl boronic acids with sp(3) carbon partners are presented. Various boronic acids were shown to react with 1,3-diesters and 1,3-diketones to afford structurally unique carbonyl compounds. By employing 2-substituted 1,3-diesters, synthetically-challenging quaternary carbon centres were accessed. In total, 42 examples of aryl carbonyl compounds were prepared in moderate to good yields. The catalytic system features the use of a bidentated phosphine ligand and a relatively low CO pressure (5 atm), providing an easy, alternative method for the preparation of triketones.
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University, Xi'an, 710062, P. R. China. xuedong_welcome@snnu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Xue
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Chen
authors.forename: Jianliang
authors.initials: J
authors.lastname: Xiao