title: Selective functionalization and loading of biomolecules in crystalline silicon nanotube field-effect-transistors.
abstract: Crystalline silicon nanotubes (Si NTs) provide distinctive advantages as electrical and biochemical analysis scaffolds through their unique morphology and electrical tunability compared to solid nanowires or amorphous/non-conductive nanotubes. Such potential is investigated in this report. Gate-dependent four-probe current-voltage analysis reveals electrical properties such as resistivity to differ by nearly 3 orders of magnitude between crystalline and amorphous Si NTs. Analysis of transistor transfer characteristics yields a field effect mobility of 40.0 cm(2) V(-1) s(-1) in crystalline Si NTs. The hollow morphology also allows selective inner/outer surface functionalization and loading capability either as a carrier for molecular targets or as a nanofluidic channel for biomolecular assays. We present for the first time a demonstration of internalization of fluorescent dyes (rhodamine) and biomolecules (BSA) in Si NTs as long as 22 μm in length.
authors.affiliation: Materials Science and Engineering Program, University of California, San Diego, La Jolla, California 92093, USA. xiang@ece.ucsd.edu.
authors.forename: Soonshin
authors.initials: S
authors.lastname: Kwon
authors.forename: Zack C Y
authors.initials: ZC
authors.lastname: Chen
authors.forename: Hyunwoo
authors.initials: H
authors.lastname: Noh
authors.forename: Ju Hun
authors.initials: JH
authors.lastname: Lee
authors.forename: Hang
authors.initials: H
authors.lastname: Liu
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Cha
authors.forename: Jie
authors.initials: J
authors.lastname: Xiang
mesh_terms: D000818:Animals; D002417:Cattle; D003460:Crystallization; D005456:Fluorescent Dyes / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000378:metabolism; D012825:Silicon / Q000737:chemistry*; D014173:Transistors, Electronic
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; D012710:Serum Albumin, Bovine; D012825:Silicon