title: Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens.
abstract: Many genetic factors influence the growth and feed intake of birds. In the current study, we evaluated the association of 8 previously reported SNP in the chicken leptin receptor (LEPR) gene with BW, BW gain (BWG), feed intake (FI), and feed conversion ratio (FCR). Four SNP with a very low minor allele frequency were removed by genotype quality control. The experimental population consisted of 796 pedigreed males from 2 genetically unrelated yellow meat-type chicken strains, 335 chickens from N202, and 461 chickens from N301. The BW at 49 (BW49) and 70 d of age (BW70) and FI (from 49 to 70 d of age) were measured individually. The BWG and FCR were calculated based on BW and FI in the interval between 49 to 70 d. The results indicated that rs14657336, rs13684613, rs13684615, and rs13684616 were found in strong linkage disequilibrium. This linkage disequilibrium block was significantly associated with BW49 (P < 0.05), BW70 (P < 0.05), and FI (P < 0.05) in the N202 strain, and FCR (P < 0.01) in the N301 strain, respectively. In addition, the GTACGTAC diplotype had the highest BWG and FI in both strains. The association revealed in this study suggests the need for further functional study on the role of LEPR gene in regulating feed intake and FCR of chickens.
authors.affiliation: National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
authors.forename: El Mostafa
authors.initials: el M
authors.lastname: El Moujahid
authors.affiliation: National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
authors.forename: Sirui
authors.initials: S
authors.lastname: Chen
authors.affiliation: National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
authors.forename: Sihua
authors.initials: S
authors.lastname: Jin
authors.affiliation: National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Guangdong Wens Nanfang Poultry Breeding Co., Ltd., Xinxing 527439, China.
authors.forename: Dexiang
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Guangdong Wens Nanfang Poultry Breeding Co., Ltd., Xinxing 527439, China.
authors.forename: Congliang
authors.initials: C
authors.lastname: Ji
authors.affiliation: National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China nyang@cau.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002645:Chickens / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D004063:Digestion; D004435:Eating; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D054411:Receptors, Leptin / Q000235:genetics*; D015430:Weight Gain
chemical_list: D054411:Receptors, Leptin
keywords: chicken; feed conversion ratio; feed intake; growth; leptin receptor