title: Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au-ZnO hybrid nanoparticles.
abstract: We have developed multifunctional Au-ZnO hybrid nanoparticles (NPs) for targeted induction lysosomal membrane permeabilization (LMP)-dependent apoptosis in cancer cells and real-time imaging.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Synergetic Innovation Center of Chemical Imaging Functionalized Probes, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P.R. China. tangb@sdnu.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Wenhua
authors.initials: W
authors.lastname: Cao
authors.forename: Huaibin
authors.initials: H
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Kehua
authors.initials: K
authors.lastname: Xu
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
mesh_terms: D017209:Apoptosis; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007425:Intracellular Membranes / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D053768:Metal Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D006046:Gold; D015034:Zinc Oxide