title: [The influences of non-surgical periodontal treatment on gingival crevicular fluid levels of MMP-8 and tissue inhibitor of TIMP-1].
abstract: OBJECTIVE
  To compare the levels of MMP-8 and TIMP-1 in the gingival crevicular fluid (GCF)of chronic periodontitis(CP) patients before and after non-surgical periodontal therapy.
  
  
  METHODS
  Sulcus bleeding index (SBI), plaque index (PLI) and probing depth (PD) were detected before and after therapy. GCF was collected from CP patients before and after therapy. MMP-8 and TIMP-1 were determined by enzyme-linked immunoabsorbent assay. The data was analyzed using paired-sample t test and multi-correlation analysis with SSPS 19.0 software package.
  
  
  RESULTS
  The levels of MMP-8 and TIMP-1 decreased after therapy, and there was no significant difference in the MMP-8/TIMP-1 ratio. Correction analysis showed that a significant correction was found between MMP-8 and GCF weight.
  
  
  CONCLUSIONS
  MMP-8 and TIMP-1 decrease after non-surgical periodontal therapy.
authors.affiliation: Department of Oral Medicine, Shanghai Stomatological Disease Center. Shanghai 200031, China.E-mail:caiju_donglixia@163.com.
authors.forename: Li-qin
authors.initials: LQ
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Feng
authors.forename: Li
authors.initials: L
authors.lastname: Sun
mesh_terms: D055113:Chronic Periodontitis; D003774:Dental Plaque Index; D005883:Gingival Crevicular Fluid; D006801:Humans; D020784:Matrix Metalloproteinase 8; D010518:Periodontitis; D019715:Tissue Inhibitor of Metalloproteinase-1
chemical_list: C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D020784:Matrix Metalloproteinase 8