title: [Discussion on research ideas of synergistic mechanism of Epimedium fried with suet oil based on self-assembled micelles formation in vivo].
abstract: Accessories processing is a major feature of traditional pharmaceutical technology in China How to use modem science and technology to reveal the scientific connotation of accessories processing, is the core of traditional Chinese medicine processing research. As traditional beneficial Chinese medicine, Epimedium can enhance the effect of warming kidney yang after processing with suet oil However, the current literature research from two aspects of chemical constituents and pharmacological action cannot fully explain the processing mechanism of accessories suet oil. According to the characteristics of fatty acids in suet oil with long chain fatty and surface activity, and based on the theoretical basis of self-assembled drug delivery system, as well as the experimental basis of Epimedium flavonoids self-assembled micelles simulated formation and promoting absorption, this paper puts forward the research hypothesis on synergistic mechanism of Epimedium fried with suet oil based on self-assembled micelles formation in vivo. This paper also describes in detail the research ideas and methods of self-assembled micelles enhancing absorption and synergistic mechanism of Epimedium flavonoids, which has the important theory significance and application value to reveal the scientific connotation of Chinese medicine fried with oil.
authors.forename: E
authors.initials: E
authors.lastname: Sun
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism; D034181:Epimedium / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D008823:Micelles; D009821:Oils / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008823:Micelles; D009821:Oils