title: Common-path diffraction optical tomography for investigation of three-dimensional structures and dynamics of biological cells.
abstract: We present an optical holographic micro-tomographic technique for imaging both the three-dimensional structures and dynamics of biological cells. Optical light field images of a sample, illuminated by a plane wave with various illumination angles, are measured in a common-path interferometry, and thus both the three-dimensional refractive index tomogram and two-dimensional dynamics of live biological cells are measured with extremely high sensitivity. The applicability of the technique is demonstrated through quantitative and measurements of morphological, chemical, and mechanical parameters at the individual cell level.
authors.forename: Youngchan
authors.initials: Y
authors.lastname: Kim
authors.forename: Hyoeun
authors.initials: H
authors.lastname: Shim
authors.forename: Kyoohyun
authors.initials: K
authors.lastname: Kim
authors.forename: HyunJoo
authors.initials: H
authors.lastname: Park
authors.forename: Ji Han
authors.initials: JH
authors.lastname: Heo
authors.forename: Jonghee
authors.initials: J
authors.lastname: Yoon
authors.forename: Chulhee
authors.initials: C
authors.lastname: Choi
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Jang
authors.forename: YongKeun
authors.initials: Y
authors.lastname: Park
mesh_terms: D002477:Cells / Q000166:cytology*; D006696:Holography; D007368:Interferometry / Q000379:methods*; D008027:Light; D012031:Refractometry / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*; D014057:Tomography, X-Ray Computed