title: Regulation of myelopoiesis by CD137L signaling.
abstract: CD137 ligand (CD137L) has emerged as a powerful regulator of myelopoiesis that links emergency situations, such as infections, to the generation of additional myeloid cells, and to their activation and maturation. CD137L is expressed on the cell surface of hematopoietic stem and progenitor cells (HSPC) and antigen presenting cells (APC) as a transmembrane protein. The signaling of CD137L into HSPC induces their proliferation and differentiation to monocytes and macrophages, and in monocytes CD137L signaling induces differentiation to potent dendritic cells (DC). CD137L signaling is initiated by CD137 which is expressed by T cells, once they become activated. Some of these activated, CD137-expressing T cells migrate from the site of infection to the bone marrow where they interact with HSPC to induce myelopoiesis, or they induce monocyte to DC differentiation locally at the site of infection. Therapeutically, induction of CD137L signaling can be utilized to reinitiate myeloid differentiation in acute myeloid leukemia cells, and to generate potent DC for immunotherapy.
authors.affiliation: 1Department of Physiology, and.
authors.forename: Qianqiao
authors.initials: Q
authors.lastname: Tang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Jiang
authors.forename: Zulkarnain
authors.initials: Z
authors.lastname: Harfuddin
authors.forename: Kin
authors.initials: K
authors.lastname: Cheng
authors.forename: Mei Chung
authors.initials: MC
authors.lastname: Moh
authors.forename: Herbert
authors.initials: H
authors.lastname: Schwarz
mesh_terms: D053330:4-1BB Ligand / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D022423:Myeloid Cells / Q000502:physiology*; D038042:Myelopoiesis / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000378:metabolism
chemical_list: D053330:4-1BB Ligand; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9
keywords: CD137; T cells; infection; myelopoiesis