title: Genomic stability: boosting cohesion corrects CIN.
abstract: Chromosomal instability is a driving force for heterogeneity within tumours. A recent study shows that boosting sister chromatid cohesion corrects chromosomal instability in pRB-deficient cancer cells. This key finding provides an important lead to make tumours more susceptible to anti-cancer drugs.
authors.affiliation: The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Ahmed M O
authors.initials: AMO
authors.lastname: Elbatsh
authors.affiliation: The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: René H
authors.initials: RH
authors.lastname: Medema
authors.affiliation: The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: b.rowland@nki.nl.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Rowland
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D043171:Chromosomal Instability; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000235:genetics*; D006801:Humans; D016160:Retinoblastoma Protein / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D016160:Retinoblastoma Protein