title: Shedding "UV" light on endogenous opioid dependence.
abstract: Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and produces an endogenous opioid-dependent state.
authors.affiliation: Synaptic Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA.
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Tejeda
authors.affiliation: Synaptic Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Electronic address: antonello.bonci@nih.gov.
authors.forename: Antonello
authors.initials: A
authors.lastname: Bonci
mesh_terms: D000818:Animals; D016739:Behavior, Addictive; D006801:Humans; D012867:Skin / Q000528:radiation effects*; D001615:beta-Endorphin / Q000378:metabolism*
chemical_list: D001615:beta-Endorphin