title: Sesquiterpenoids from Chloranthus henryi and their anti-neuroinflammatory activities.
abstract: Five new and seven known mono-sesquiterpenoids (1-5 and 6-12, resp.) together with five known lindenane-type disesquiterpenoids, 13-17, were isolated from the whole plant of Chloranthus henryi. Based on spectroscopic methods, the new structures were established to be (5S,6R,8S,10R)-6-hydroxyeudesma-4(15),7(11)-diene-12,8-olide (1), 6α-hydroxyeudesma-4(15),7(11),8(9)-triene-12,8-olide (2), 8,12-epoxy-1β-hydroxyeudesma-4(15),7,11-trien-6-one (3), 12-oxochloraniolide A (4), and (4α)-8-hydroxy-12-norcardina-6,8,10-trien-11-one (5), respectively. Among the isolates, compound 2, zederone epoxide (8), spicachlorantin G (13), chloramultilide A (14), shizukaol B (15), and spicachlorantin B (17) showed significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, P. R. China, (phone/fax: +86 21 51980172).
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.forename: Shu-Ting
authors.initials: ST
authors.lastname: Liu
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D017628:Microglia / Q000187:drug effects* / Q000378:metabolism; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Anti-neuroinflammation; Chloranthus henryi; Lindenane dimers; Sesquiterpenes