title: Primary esophageal sclerosing mucoepidermoid carcinoma with "tissue eosinophilia".
abstract: Mucoepidermoid carcinoma (MEC) is a rare primary esophageal malignancy. It is characterized by poor clinical recognition, pre-operative diagnostic challenges and a lack of standardized therapeutic guidelines. We report the clinicopathological features of a hitherto unreported variant of esophageal MEC, sclerosing MEC with "tissue eosinophilia", in a mid-esophageal location in a 51-year-old female. The diagnosis of the initial biopsy was challenging, because of the small size, poor orientation and inadequate representation of the MEC components. Recognition of the resectability of the tumor prompted surgical resection and enabled a demonstration of the low grade foci containing intermediate cells, mucin pools and the hitherto undescribed presence of stromal sclerosis and tissue eosinophils in esophageal MEC. Heightened clinicopathological awareness of esophageal MEC facilitated a definitive diagnosis and patient management. Increased recognition and global documentation of esophageal sclerosing MEC with "tissue eosinophilia" is necessary to improve the understanding and diagnosis of this malignancy in this location and to improve management guidelines.
authors.affiliation: Suman Mewa Kinoo, Kapil Maharaj, Bhugwan Singh, Department of Surgery, Nelson R Mandela School of Medicine, University of Kwazulu Natal, Durban 4013, South Africa.
authors.forename: Suman
authors.initials: S
authors.lastname: Mewa Kinoo
authors.affiliation: Suman Mewa Kinoo, Kapil Maharaj, Bhugwan Singh, Department of Surgery, Nelson R Mandela School of Medicine, University of Kwazulu Natal, Durban 4013, South Africa.
authors.forename: Kapil
authors.initials: K
authors.lastname: Maharaj
authors.affiliation: Suman Mewa Kinoo, Kapil Maharaj, Bhugwan Singh, Department of Surgery, Nelson R Mandela School of Medicine, University of Kwazulu Natal, Durban 4013, South Africa.
authors.forename: Bhugwan
authors.initials: B
authors.lastname: Singh
authors.affiliation: Suman Mewa Kinoo, Kapil Maharaj, Bhugwan Singh, Department of Surgery, Nelson R Mandela School of Medicine, University of Kwazulu Natal, Durban 4013, South Africa.
authors.forename: Michelle
authors.initials: M
authors.lastname: Govender
authors.affiliation: Suman Mewa Kinoo, Kapil Maharaj, Bhugwan Singh, Department of Surgery, Nelson R Mandela School of Medicine, University of Kwazulu Natal, Durban 4013, South Africa.
authors.forename: Pratistadevi Kanaye
authors.initials: PK
authors.lastname: Ramdial
mesh_terms: D001706:Biopsy; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology* / Q000601:surgery; D004802:Eosinophilia / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D006801:Humans; D008875:Middle Aged; D012598:Sclerosis; D016896:Treatment Outcome
keywords: Carcinoma; Esophagus; Mucoepidermoid; Sclerosing; Tissue eosinophilia