title: MicroRNAs in cancer: glioblastoma and glioblastoma cancer stem cells.
abstract: MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their dysregulation plays major roles in many cancer types. Gliomas are cancers arising from the central nervous system. The most malignant and common glioma is glioblastoma multiforme (GBM), and even with aggressive treatment (surgical resection, chemotherapy, and radiation), average patient survival remains less than 2 years. In this review we will summarize the current findings regarding microRNAs in GBM and the biological and clinical implications of this data.
authors.affiliation: Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
authors.forename: Jeffrey V
authors.initials: JV
authors.lastname: Brower
authors.affiliation: Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Clark
authors.affiliation: Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
authors.forename: Will
authors.initials: W
authors.lastname: Lyon
authors.affiliation: Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
authors.forename: John S
authors.initials: JS
authors.lastname: Kuo
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism*; D005909:Glioblastoma / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Cancer; Cancer stem cells; Glioblastoma; Glioma; MicroRNA