title: Pharmacokinetics of liver-targeted docetaxel liposomes modified with 6-O-acyl-D-galactose esters in rabbits.
abstract: The purpose of the present study was to investigate the pharmacokinetics of docetaxel liposomes modified with 6-O-acyl-D-galactose esters (Gal-DOC-L) in rabbits. A simple, rapid and sensitive high-performance liquid chromatography (HPLC) method was developed for the determination of docetaxel. Gal-DOC-L was intravenously administered to rabbits with norethisterone as the internal standard and the blood samples were collected from ear marginal veins at 0.083, 0.25, 0.5, l, 2, 4, 6, 8, 12, 16 and 24 h after treatment. The plasma concentration of docetaxel was determined by HPLC and the pharmacokinetic parameters were calculated. Docetaxel injection (DOC-I) was studied simultaneously. The results showed that the area under the curve(0-∞), t1/2αand t1/2βof Gal-DOC-L was significantly higher, while the total body clearance was lower than that of DOC-I. The results indicated that Gal-DOC-L was able to maintain a relatively high blood concentrationin vivoand prolong the treatment time.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China ; School of Pharmacy, Guilin Medical University, Guilin, Guangxi 541004, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Bo-Hong
authors.initials: BH
authors.lastname: Guo
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
keywords: 6-O-acyl-D-galactose; docetaxel liposomes; high-performance liquid chromatography; pharmacokinetics