title: Cytotoxic mannopyranosides of indole alkaloids from Zanthoxylum nitidum.
abstract: Three new mannopyranosides of indole alkaloids, methyl 7-(β-D-mannopyranosyloxy)-1H-indole-2-carboxylate (1), methyl 7-[(3-O-acetyl-β-D-mannopyranosyl)oxy]-1H-indole-2-carboxylate (2), and 2-methyl-1H-indol-7-yl β-D-mannopyranoside (3), were isolated from an EtOH extract of the roots of Zanthoxylum nitidum. Their structures were identified as new compounds on the basis of the spectroscopic analyses. Bioactivity evaluation revealed that these alkaloids possess significant cytotoxicities against all the tested tumor cell lines with IC50 values of less than 30 μM.
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing 655011, P. R. China, (phone/fax: +86-874-8998627); Institute of Characteristic Medicinal Resource of Ethnic Minorities, Qujing Normal University, Qujing 655011, P. R. China. hujiang@ustc.edu.
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi
authors.forename: Xia
authors.initials: X
authors.lastname: Mao
authors.forename: Jiangang
authors.initials: J
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D008358:Mannose / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013329:Structure-Activity Relationship; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D008358:Mannose
keywords: Alkaloids; Cytotoxic activity; Indole alkaloids; Mannopyranosides; Zanthoxylum nitidum