title: [Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population].
abstract: OBJECTIVE
  To assess the association of neural development-related genes LIS1and TSNAX with bipolar disorder in a Chinese Han population.
  
  
  METHODS
  Three hundred and eight five patients (including 188 males and 197 females) from Guangzhou Brain Hospital with bipolar disorder meeting the Diagnostic and Statistic Manual of Bipolar Disorder (BDI) (Fourth Edition) criteria and 475 healthy controls from the local community were recruited. Ten single nucleotide polymorphisms (SNPs) of the LIS1 and TSNAX genes were genotyped by GoldenGate genotyping assay on an Illumina Beadstation 500 machine. Association analyses of SNPs and haplotypes were performed with Plink 1.07 software.
  
  
  RESULTS
  Analysis of the total sample has failed to find any association of SNP or haplotype of the two genes with BDI (P> 0.05). When patients were divided into subgroups with or without psychotic symptom, no significant association of the two genes was found with psychotic BDI or non-psychotic BDI (P> 0.05). No significant association was found between any SNP and haplotype of two genes and female BDI or male BDI, nor were significant association found between age of onset and LIS1 and TSNAX gene polymorphisms.
  
  
  CONCLUSIONS
  Our results indicated that LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.
authors.affiliation: Early Intervention Department of Guangzhou Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510370, P. R. China. Email: coolliping@hotmail.com.
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
authors.forename: Lijie
authors.initials: L
authors.lastname: Guan
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.forename: Wenhao
authors.initials: W
authors.lastname: Deng
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Yang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.forename: Guohui
authors.initials: G
authors.lastname: Lao
authors.forename: Biyu
authors.initials: B
authors.lastname: Ye
authors.forename: Weijie
authors.initials: W
authors.lastname: Huang
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Jiang
authors.forename: Guodong
authors.initials: G
authors.lastname: Miao
authors.forename: Guiyun
authors.initials: G
authors.lastname: Xu
authors.forename: Wentao
authors.initials: W
authors.lastname: Liu
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D001714:Bipolar Disorder / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D008869:Microtubule-Associated Proteins; C498305:TSNAX protein, human; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C084102:PAFAH1B1 protein, human