title: Screening tests using serum tissue transglutaminase IgA may facilitate the identification of undiagnosed celiac disease among Japanese population.
abstract: The prevalence of celiac disease (CD) among Japanese population has been unknown, whereas it has been increasingly recognized in the US and in the European countries. The aim of the present study is to identify possible cases with CD among Japanese population and clarify the relevance of screening for the disease. We conducted a serologic screening for the disease among 710 Japanese patients and 239 healthy volunteers at a local tertiary teaching hospital, using an anti-tissue transglutaminase IgA (TTG-IgA) test, and histological examination of the small intestines from the TTG-IgA positive subjects. There were no TTG-IgA positive sera among the healthy volunteers. Twenty of the patients (2.8%), including eight with malignant lymphoma, were tested positive for TTG-IgA. The histological examination of the eleven patients among those with positive TTG-IgA, seven showed villous atrophy and partial lymphocytes infiltration in the mucosa, which could be compatible to mucosal changes observed in CD. Five of them had non-Hodgkin lymphoma in the gastrointestinal tracts. Serologic tests using TTG-IgA might be relevant to screen for those with undiagnosed CD among Japanese population.
authors.affiliation: 1. Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nakazawa
authors.affiliation: 1. Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Hideki
authors.initials: H
authors.lastname: Makishima
authors.affiliation: 1. Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ito
authors.affiliation: 2. Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Ota
authors.affiliation: 1. Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Kayoko
authors.initials: K
authors.lastname: Momose
authors.affiliation: 1. Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Nodoka
authors.initials: N
authors.lastname: Sekiguchi
authors.affiliation: 3. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Kaname
authors.initials: K
authors.lastname: Yoshizawa
authors.affiliation: 4. Department of Endoscopy, Shinshu University Hospital, 3-1-1 Asahi Matsumoto, Japan 390-8621.
authors.forename: Taiji
authors.initials: T
authors.lastname: Akamatsu
authors.affiliation: 1. Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621; ; 2. Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Japan 390-8621;
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ishida
mesh_terms: D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D002446:Celiac Disease / Q000097:blood* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012698:Serologic Tests; D011503:Transglutaminases / Q000097:blood* / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D011503:Transglutaminases
keywords: anti-tissue transglutaminase IgA; celiac disease; malignant lymphoma; screening