title: Ag@4ATP-coated liposomes: SERS traceable delivery vehicles for living cells.
abstract: A liposome-Ag nanohybrid has been demonstrated as a SERS traceable intracellular drug nanocarrier. Liposomes have been introduced for their special qualities in drug delivery systems. In essence, 4-aminothiophenol (4ATP) tagged Ag nanoparticles (Ag@4ATP) were adsorbed onto the surfaces of liposomes via electrostatic interactions, in which 4ATP was used as a SERS reporter. In such a nanohybrid, the locations of the carrier can be tracked by SERS signals while those of the drugs can be monitored through their fluorescence, allowing the simultaneous investigation of the intracellular distribution of both the carriers and the drugs. Our experimental results suggest that the reported liposomal system has substantial potential for intracellular drug delivery.
authors.affiliation: Advanced Photonics Center, Southeast University, 2# Sipailou, Nanjing 210096, Jiangsu, China. cyp@seu.edu.cn wangzy@seu.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
authors.forename: Zhuyuan
authors.initials: Z
authors.lastname: Wang
authors.forename: Shenfei
authors.initials: S
authors.lastname: Zong
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Pei
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Xueqin
authors.initials: X
authors.lastname: Ma
authors.forename: Yiping
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D018613:Microscopy, Confocal; D017830:Octoxynol / Q000737:chemistry; D010316:Particle Size; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D055672:Static Electricity; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D013438:Sulfhydryl Compounds; D012834:Silver; D006046:Gold; D004317:Doxorubicin; C064316:4-aminothiophenol; D017830:Octoxynol