title: New triterpenoids from the fruiting bodies of Ganoderma lucidum and their bioactivities.
abstract: Phytochemical investigation of the AcOEt extract of G. Lucidum has led to the isolation of two new triterpenoids, 1 and 2, together with five known ones, 3-7. The structures of the new compounds were identified as 12β-acetoxy-3β,7β-dihydroxy-11,15,23-trioxolanost-8-en-26-oic acid butyl ester (1) and 12β-acetoxy-3,7,11,15,23-pentaoxolanost-8-en-26-oic acid butyl ester (2) on the basis of detailed spectroscopic analysis (mass spectrometry, and 1D- and 2D-NMR experiments). The antimicrobial activities of 1 and 2 were also evaluated.
authors.affiliation: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China. liudongze0923@sina.com.
authors.forename: Dong-Ze
authors.initials: DZ
authors.lastname: Liu
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Li
authors.forename: Wei-Gang
authors.initials: WG
authors.lastname: Shan
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Gao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D020940:Reishi / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014315:Triterpenes
keywords: Antimicrobial activity; Fungi; Ganoderma lucidum; Lanostane; Triterpenoids