title: Association between HMW adiponectin, HMW-total adiponectin ratio and early-onset coronary artery disease in Chinese population.
abstract: OBJECTIVE
  Adiponectin is an adipose-secreting protein that shows atheroprotective property and has inverse relation with coronary artery disease (CAD). High-molecular weight (HMW) adiponectin is reported as the active form of adiponectin. In the present study, we aimed to investigate the association between total adiponectin, HMW adiponectin, HMW-total adiponectin ratio and the severity of coronary atherosclerosis, and to compare their evaluative power for the risk of CAD.
  
  
  METHODS
  Serum levels of total and HMW adiponectin were measured in 382 early-onset CAD (EOCAD) patients and 305 matched controls undergoing coronary angiography by enzyme-linked immunosorbent assay (ELISA). Gensini score was used to evaluate the severity of coronary atherosclerosis.
  
  
  RESULTS
  CAD onset age was positively correlated with HMW adiponectin (r = 0.383, P < 0.001) and HMW-total adiponectin ratio (r = 0.429, P < 0.001) in EOCAD patients. Total and HMW adiponectin and HMW-total adiponectin ratio were all inversely correlated with Gensini score (r = -0.417, r = -0.637, r = -0.578, respectively; all P < 0.001). Multivariate binary logistic regression analysis demonstrated that HMW adiponectin and HMW-total adiponectin ratio were both inversely correlated with the risk of CAD (P < 0.05). ROC analysis indicated that areas under the ROC curves of HMW adiponectin and HMW-total adiponectin ratio were larger than that of total adiponectin (P < 0.05).
  
  
  CONCLUSIONS
  Adiponectin is cardioprotective against coronary atherosclerosis onset in EOCAD patients. HMW adiponectin and HMW-total adiponectin ratio show stronger negative associations with the severity of coronary atherosclerosis than total adiponectin does. HMW adiponectin and HMW-total adiponectin ratio are effective biomarkers for the risk of CAD in Chinese population.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China.
authors.forename: Qianran
authors.initials: Q
authors.lastname: Kong
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Qin
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1#Yixueyuan Road, Chongqing 400016, China. Electronic address: zdy.chris@gmail.com.
authors.forename: Dongying
authors.initials: D
authors.lastname: Zhang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D017668:Age of Onset; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood; D006801:Humans; D008970:Molecular Weight
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: Coronary atherosclerosis; Early-onset coronary artery disease; Gensini score; HMW adiponectin; HMW-total adiponectin ratio