title: Serological and molecular capsular typing, antibiotic susceptibility of Streptococcus pneumoniae isolates from invasive and non-invasive infections.
abstract: Streptococcus pneumoniae causes life threatening infections and necessitate for impediment and controlling disease; to conquer this, information is needed about serotype distribution and patterns of antibiotic resistance. The present study was to determine the serotype distribution of S. pneumoniae isolated from the entire age group individual and to correlate this distribution with susceptibility. Cases of pneumococcal infections have been reviewed for serotyping and antibiotic susceptibility. Out of 117 pneumococcal isolates 45 (39%) were penicillin-resistant, 84 (72%) were erythromycin-resistant and 100% were co-trimoxazole resistant. The most frequently isolated serotypes were 23F, 19F, 14, 6B, 5, 6A, 19A and 9V. PCV7, PCV10 and PCV13 coverage was 68%, 79%, 87%, respectively. Similarly, there was similarity in PCV7 coverage for non invasive isolates (64.5%) and invasive isolates (72.2%). The study state that common pneumococcal serotypes were present in similar ways as reported in literature. A continuous survey of pneumococcal infected population is requirement and necessity for success of vaccination.
authors.affiliation: King Saud University Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Po Box 10219 Riyadh 11433 Saudi Arabia.
authors.forename: Lakshmana Gowda
authors.initials: LG
authors.lastname: Krishnappa
authors.affiliation: King Saud University Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Po Box 10219 Riyadh 11433 Saudi Arabia.
authors.forename: Mohammed Ali M
authors.initials: MA
authors.lastname: Marie
authors.affiliation: Loyola College (Autonomous) Department of Zoology and Advance Biotechnology Chennai India.
authors.forename: James
authors.initials: J
authors.lastname: John
authors.affiliation: King Saud University Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Po Box 10219 Riyadh 11433 Saudi Arabia.
authors.forename: Khaled Homoud M
authors.initials: KH
authors.lastname: Dabwan
authors.affiliation: King Saud University Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Po Box 10219 Riyadh 11433 Saudi Arabia.
authors.forename: Pradeep Chikkabidare
authors.initials: PC
authors.lastname: Shashidhar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016667:Bacterial Capsules / Q000737:chemistry* / Q000145:classification; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology; D012529:Saudi Arabia / Q000453:epidemiology; D012703:Serotyping / Q000379:methods*; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000145:classification / Q000302:isolation & purification*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D004917:Erythromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: meningitis; pneumonia; serotyping; vaccine