title: [Research progress in human enterovirus recombination].
abstract: Complex genetic variation has been known to occur during the transmission of human enterovirus (HEV), and the HEV virulence and pathogenicity enhanced by genetic recombination also pose a serious threat to human health. In recent years, the interest in recombination mechanism of genetic plasticity has been renewed with the emergence of pathogenic recombinant circulating vaccine-derived polioviruses, which were implicated in poliomyelitis outbreaks in several regions of the world with insufficient vaccination coverage. This paper reviews recent research progress in HEV genome, including evolutionary characteristics, recombination types, and in vitro recombinant construction.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Ze-Xin
authors.initials: ZX
authors.lastname: Tao
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Zhang
authors.forename: Ai-Qiang
authors.initials: AQ
authors.lastname: Xu
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D004770:Enterovirus / Q000145:classification / Q000235:genetics*; D004769:Enterovirus Infections / Q000821:virology*; D006801:Humans; D011995:Recombination, Genetic; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins