title: Relation between ultra-sensitive C-reactive protein, diabetes and periodontal disease in patients with and without myocardial infarction.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the impact of diabetes and periodontal disease in us-CRP, an inflammatory marker in patients with and without acute myocardial infarction (AMI).
  
  
  METHODS
  A case-control study was conducted in 401 subjects aged between 30 and 75 years, living in Bogotá D.C. (Colombia). Patients arriving at the emergency room of the San Ignacio University Hospital with AMI were included into the case group. The control group was defined as those subjects without AMI. The following blood tests were performed: complete blood count (CBC), glycemia, total cholesterol, triglycerides, cHDL, cLDL, and us-CRP. Patients with infections or antibiotic treatment within the last three months, who had received periodontal treatment within the six months prior to the study entry, had oral ulcerations, or less than seven teeth were excluded from the study. Periodontal disease was diagnosed based on the 1999 Armitage's classification.
  
  
  RESULTS
  The mean us-CRP value found in diabetic patients with severe chronic periodontitis was 5.31 mg/L (SD 6.82), and 2.38 mg/L (SD 4.42) in non-diabetic patients, being statistically significant (p = 0.000).
  
  
  CONCLUSIONS
  Diabetes had an impact in periodontal disease and us-CRP. In patients with AMI, DM and PD considerably increased the us-CRP.
authors.affiliation: Periodontal Department, School of Dentistry, Pontificia Universidad Javeriana and Fundación Cardio Infantil, Bogotá, Colombia.
authors.forename: Francina Escobar
authors.initials: FE
authors.lastname: Arregoces
authors.affiliation: Periodontal Department, School of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Catalina Latorre
authors.initials: CL
authors.lastname: Uriza
authors.affiliation: Periodontal Department, School of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Juliana Velosa
authors.initials: JV
authors.lastname: Porras
authors.affiliation: Periodontal Department, School of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Maria Beatriz Ferro
authors.initials: MB
authors.lastname: Camargo
authors.affiliation: Department of Internal Medicine and Department of Clinical Epidemiology, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Alvaro Ruiz
authors.initials: AR
authors.lastname: Morales
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood* / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010510:Periodontal Diseases / Q000097:blood / Q000175:diagnosis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol