title: Biomechanical analysis of an interbody cage with three integrated cancellous lag screws in a two-level cervical spine fusion construct: an in vitro study.
abstract: BACKGROUND
  Despite an increase in the clinical use of no-profile anchored interbody cages (AIC) for anterior cervical discectomy and fusion (ACDF) procedures, there is little published biomechanical data describing its stabilizing effect relative to the traditional anterior plating technique over two contiguous levels.
  
  
  OBJECTIVE
  To biomechanically compare the acute stability conferred by a stand-alone interbody fusion device with three integrated fixation screws ("anchored cage") with a traditional six-hole rigid anterior plate in a two contiguous levels (C4-C5+C5-C6) fusion construct. We hypothesized that the anchored cage would confer comparable segmental rigidity to the cage and anterior plate construct.
  
  
  METHODS
  A biomechanical laboratory study using cadaveric human cervical spines.
  
  
  METHODS
  Seven (n=7) cadaveric human cervical spines (C3-C7) were subjected to quasistatic, pure-moment loading (±1.5 Nm) in flexion-extension (flex/ext), right/left lateral bending (RB/LB), and right/left axial rotation (RR/LR) for the following test conditions: intact; after discectomy and insertion of the AIC at C4-C5 and C5-C6 with anchoring screws engaged; after the removal of the integrated anchoring screws and instrumentation of an anterior locking plate (ALP) over both levels; and cage-only (CO) configuration with screws and anterior plate removed. Intervertebral range of motion (ROM) at the instrumented levels was the primary biomechanical outcome.
  
  
  RESULTS
  Flex/ext, RB/LB, and RR/LR ROMs were significantly reduced (p<.001) over both levels by AIC and ALP constructs relative to the CO construct. Significant reduction in flex/ext motion was achieved with the ALP (6.8±3.7) relative to the AIC (10.2°±4.6°) (p=.041) construct. No significant differences were seen in ROM reductions over the two levels between the AIC and APL groups in lateral bending or axial rotation (p>.826).
  
  
  CONCLUSIONS
  The anchored cage fusion construct conferred similar acute biomechanical stability in lateral bending and axial rotation ROMs relative to rigid anterior plating. We identified a statistically significant reduction (Δ=3.4°, combined over two levels) in sagittal plane ROM conferred by the ALP relative to the AIC construct. Our biomechanical findings may support the clinical use of no-profile integrated interbody devices over two contiguous levels in ACDF.
authors.affiliation: Phillip Spiegel Orthopaedic Research Laboratory, Foundation for Orthopaedic Research & Education, 13020 N. Telecom Parkway, Tampa, FL 33637, USA.
authors.forename: Aniruddh N
authors.initials: AN
authors.lastname: Nayak
authors.affiliation: Department of Orthopaedic & Sports Medicine, University of South Florida, 3220 USF Laurel Drive, MDC106, Tampa, FL 33612, USA.
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Stein
authors.affiliation: Phillip Spiegel Orthopaedic Research Laboratory, Foundation for Orthopaedic Research & Education, 13020 N. Telecom Parkway, Tampa, FL 33637, USA.
authors.forename: Chris R
authors.initials: CR
authors.lastname: James
authors.affiliation: Department of Orthopaedic & Sports Medicine, University of South Florida, 3220 USF Laurel Drive, MDC106, Tampa, FL 33612, USA.
authors.forename: Roger B
authors.initials: RB
authors.lastname: Gaskins
authors.affiliation: Phillip Spiegel Orthopaedic Research Laboratory, Foundation for Orthopaedic Research & Education, 13020 N. Telecom Parkway, Tampa, FL 33637, USA.
authors.forename: Andres F
authors.initials: AF
authors.lastname: Cabezas
authors.affiliation: Center for Spinal Disorders, Florida Orthopaedic Institute, 13020 N. Telecom Parkway, Tampa, FL 33637, USA.
authors.forename: Maxwell
authors.initials: M
authors.lastname: Adu-Lartey
authors.affiliation: Center for Spinal Disorders, Florida Orthopaedic Institute, 13020 N. Telecom Parkway, Tampa, FL 33637, USA.
authors.forename: Antonio E
authors.initials: AE
authors.lastname: Castellvi
authors.affiliation: Phillip Spiegel Orthopaedic Research Laboratory, Foundation for Orthopaedic Research & Education, 13020 N. Telecom Parkway, Tampa, FL 33637, USA; Department of Orthopaedic & Sports Medicine, University of South Florida, 3220 USF Laurel Drive, MDC106, Tampa, FL 33612, USA. Electronic address: bsantoni@foreonline.org.
authors.forename: Brandon G
authors.initials: BG
authors.lastname: Santoni
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D001863:Bone Screws; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D016059:Range of Motion, Articular; D013123:Spinal Fusion / Q000379:methods*
keywords: ACDF; Anterior locking plate; Biomechanics; Cervical spine; Integrated screws; Multi-level cervical arthrodesis; No-profile interbody device