title: Nanopores formed by DNA origami: a review.
abstract: Nanopores have emerged over the past two decades to become an important technique in single molecule experimental physics and biomolecule sensing. Recently DNA nanotechnology, in particular DNA origami, has been used for the formation of nanopores in insulating materials. DNA origami is a very attractive technique for the formation of nanopores since it enables the construction of 3D shapes with precise control over geometry and surface functionality. DNA origami has been applied to nanopore research by forming hybrid architectures with solid state nanopores and by direct insertion into lipid bilayers. This review discusses recent experimental work in this area and provides an outlook for future avenues and challenges.
authors.affiliation: Cavendish Laboratory, Cambridge University, J J Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
authors.forename: Nicholas A W
authors.initials: NA
authors.lastname: Bell
authors.affiliation: Cavendish Laboratory, Cambridge University, J J Thomson Avenue, Cambridge CB3 0HE, United Kingdom. Electronic address: ufk20@cam.ac.uk.
authors.forename: Ulrich F
authors.initials: UF
authors.lastname: Keyser
mesh_terms: D004247:DNA / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D058608:Nanopores; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation
chemical_list: D008051:Lipid Bilayers; D004247:DNA
keywords: DNA origami; Nanopores; Nanotechnology; Self-assembly; Single molecule