title: [Processing mechanism of Epimedium fried with suet oil based on absorption and metabolism of flavonoids].
abstract: As beneficial traditional Chinese medicine, Epimedium fried with suet oil can enhance the effect of warming kidney yang. Previous literature studies about processing of Epimedium mainly focused on changes in chemical composition and pharmacological effect. From the angle of flavonoids absorption and metabolism, our group innovatively study the processing mechanism of Epimedium based on active component transformation combined with intestinal absorption barrier. The processing effect of fried Epimedium can be divided into two key aspects of " heat" during processing and processing accessories "suet oil". Through continuous three National Natural Science Foundation items, the research group has clarified the scientific connotation of "heat" during processing with ADME, and explains the synergistic mechanism of processing accessories "suet oil" based on self-assembled micelles formation in vivo for the first time. This paper summarizes the research ideas and results of Epimedium processing mechanism of the project team for many years, and discusses the future research direction and content, in order to provide new ideas and new methods for modern Chinese medicine processing mechanism.
authors.forename: E
authors.initials: E
authors.lastname: Sun
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Wei
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Xu
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D000818:Animals; D018938:Caco-2 Cells; D004339:Drug Compounding / Q000379:methods*; D034181:Epimedium / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption; D009821:Oils / Q000737:chemistry*; D051381:Rats
chemical_list: D005419:Flavonoids; D009821:Oils