title: AKAP5 keeps L-type channels and NFAT on their toes.
abstract: In this issue of Cell Reports, Murphy et al. and Dittmer et al. present exciting new insight into the regulation of Ca2+ influx via the L-type Ca2+ channel Cav1.2 and how increased Ca2+ influx translates into localized activation of the nuclear transcription factor NFAT upon depolarization in neurons.
authors.affiliation: Department of Pharmacology, University of California, Davis, CA 95615, USA. Electronic address: mfnavedo@ucdavis.edu.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Navedo
authors.affiliation: Department of Pharmacology, University of California, Davis, CA 95615, USA. Electronic address: jwhell@ucdavis.edu.
authors.forename: Johannes W
authors.initials: JW
authors.lastname: Hell
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D049229:Dendritic Spines / Q000378:metabolism*; D006801:Humans; D050778:NFATC Transcription Factors / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D054758:A Kinase Anchor Proteins; D020746:Calcium Channels, L-Type; D050778:NFATC Transcription Factors; D017868:Cyclic AMP-Dependent Protein Kinases; D019703:Calcineurin; D002118:Calcium