title: Lofexidine and desipramine: Interaction results in breakthrough opioid withdrawal symptoms.
abstract: A patient was receiving treatment for concurrent opioid and stimulant dependency. When desipramine was added to his lofexidine regimen for treatment of stimulant withdrawal, there was an exacerbation of opioid withdrawal symptoms. With the increasing use of lofexidine for opioid withdrawal, clinicians need to be aware of the potential for interactions with tricyclic antidepressants in the treatment of concomitant stimulant users. (Int J Psych Clin Pract 2002; 6: 179-181 ).
authors.forename: Francis
authors.initials: F
authors.lastname: Keaney
authors.forename: Helen
authors.initials: H
authors.lastname: Crimlisk
authors.forename: Jennifer
authors.initials: J
authors.lastname: Bearn
keywords: Lofexidine Desipramine Drug-INTERACTION; Opioid Withdrawal