title: A retrospective study on combination therapy with ifosfamide, adriamycin and cisplatin for progressive or recurrent uterine sarcoma.
abstract: There is currently insufficient evidence to recommend a specific chemotherapeutic regimen as standard treatment for uterine sarcomas. In this study, we investigated the toxicity and effectiveness of ifosfamide, adriamycin and cisplatin (IAP therapy) in patients with progressive and recurrent uterine sarcoma. A total of 11 patients with progressive or recurrent uterine sarcoma containing leiomyosarcoma (LMS), undifferentiated endometrial sarcoma (UES) or adenosarcoma, who were diagnosed at our institution, were retrospectively investigated. We recorded the adverse events, response rate and progression-free survival in these cases. The histological types included LMS (54.5%), adenosarcoma (27.3%) and UES (18.2%). Grade ≥3 leukopenia or neutropenia were observed in all the cases, febrile neutropenia developed in 45.5% of the patients and grade 4 thrombocytopenia developed in 3 cases (27.3%). With IAP therapy, the response rate was 36.4% and the disease control rate was 90.9%. Therefore, IAP therapy may be a viable option as chemotherapy for uterine sarcoma.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamagami
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ninomiya
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Kuwahata
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Takigawa
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nomura
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Kataoka
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Tominaga
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Banno
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuda
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
keywords: adriamycin; chemotherapy; cisplatin; ifosfamide; uterine sarcoma