title: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) induced by oral metronidazole.
abstract: Baboon syndrome is a special form of systemic contact dermatitis to systemic or local administration of contact allergens. Baboon syndrome without known previous cutaneous sensitisation was also described as drug-related baboon syndrome or symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). The major drugs causing SDRIFE was beta-lactam antibiotic such as amoxicillin and ampicillin. We report a case of 16-year-old woman who developed pruritic eruptions after oral metronidazole treatment for diarrhea. She was diagnosed SDRIFE according to her clinical and histopathological findings. To our knowledge, our patient is the first case who developed SDRIFE due to metronidazole in the literature.
authors.affiliation: Department of Dermatology and.
authors.forename: Aysun
authors.initials: A
authors.lastname: Şikar Aktürk
authors.forename: Dilek
authors.initials: D
authors.lastname: Bayramgürler
authors.forename: Selma
authors.initials: S
authors.lastname: Salman
authors.forename: Kürşat Demir
authors.initials: KD
authors.lastname: Yıldız
authors.forename: Evren
authors.initials: E
authors.lastname: Odyakmaz Demirsoy
mesh_terms: D000293:Adolescent; D000994:Antitrichomonal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002081:Buttocks / Q000473:pathology; D003967:Diarrhea / Q000150:complications / Q000188:drug therapy; D003875:Drug Eruptions / Q000473:pathology*; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology
chemical_list: D000994:Antitrichomonal Agents; D008795:Metronidazole
keywords: Baboon syndrome; drug eruption; metronidazole