title: Obesity, hypertension and diabetes mellitus affect complication rate of different nephrectomy techniques.
abstract: BACKGROUND
  To investigate whether obesity, hypertension, and diabetes mellitus (DM) would increase post-nephrectomy complication rates using standardized classification method.
  
  
  METHODS
  We retrospectively included 843 patients from March 2006 to November 2012, of whom 613 underwent radical nephrectomy (RN) and 229 had partial nephrectomy (PN). Modified Clavien classification system was applied to quantify complication severity of nephrectomy. Fisher's exact or chi-square test was used to assess the relationship between complication rates and obesity, hypertension, as well as DM.
  
  
  RESULTS
  The prevalence of obesity, hypertension, and DM was 11.51%, 30.84%, 8.78%, respectively. The overall complication rate was 19.31%, 30.04%, 35.71% and 36.36% for laparoscopic radical nephrectomy (LRN), open-RN, LPN and open-PN respectively. An increasing trend of low grade complication rate as BMI increased was observed in LRN (P=.027) and open-RN (P<.001). Obese patients had greater chance to have low grade complications in LRN (OR=4.471; 95% CI: 1.290-17.422; P=0.031) and open-RN (OR=2.448; 95% CI: 1.703-3.518; P<.001). Patients with hypertension were more likely to have low grade complications, especially grade ii complications in open-RN (OR=1.526; 95% CI: 1.055-2.206; P=.026) and open PN (OR=2.032; 95% CI: 1.199-3.443; P=.009). DM was also associated with higher grade i complication rate in open-RN (OR=2.490; 95% CI: 331-4.657; P=.016) and open-PN (OR=4.425; 95% CI: 1.815-10.791; P=.013). High grade complication rates were similar in comparison.
  
  
  CONCLUSIONS
  Obesity, hypertension, and DM were closely associated with increased post-nephrectomy complication rates, mainly low grade complications.
authors.affiliation: Departamento de Urología, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: X
authors.initials: X
authors.lastname: Hua
authors.affiliation: Departamento de Nefrología, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: C
authors.initials: C
authors.lastname: Ying-Ying
authors.affiliation: Departamento de Urología, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: F
authors.initials: F
authors.lastname: Zu-Jun
authors.affiliation: Departamento de Urología, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: X
authors.initials: X
authors.lastname: Gang
authors.affiliation: Departamento de Urología, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: X
authors.initials: X
authors.lastname: Zu-Quan
authors.affiliation: Departamento de Urología, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: D
authors.initials: D
authors.lastname: Qiang
authors.affiliation: Departamento de Urología, Huashan Hospital, Fudan University, Shanghai, PR, China. Electronic address: haowen_jiang@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Hao-Wen
mesh_terms: D048909:Diabetes Complications / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects* / Q000379:methods*; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Complicación; Complication; Diabetes mellitus; Hipertensión; Hypertension; Nefrectomía; Nephrectomy; Obesidad; Obesity