title: Analysis of biologically active oxyprenylated ferulic acid derivatives in Citrus fruits.
abstract: 4'-Geranyloxyferulic (GOFA) and boropinic acid have been discovered during the last decade as interesting phytochemicals having valuable pharmacological effects as cancer chemopreventive, anti-inflammatory, neuroprotective, and anti-Helicobacter pylori agents. A reverse-phase HPLC-UV/Vis method for the separation and quantification of the title oxyprenylated ferulic acid derivatives in extracts obtained from peels of nine edible Citrus and Fortunella fruits was successfully applied. Concentration values showed a great variation between the different species, being orange (C. sinensis) the fruit richest in GOFA (0.141 ± 0.011 mg/g of exocarp fresh weight) and kumquat (Fortunella japonica) the one in which boropinic acid was recorded as the most abundant phytochemical (0.206 ± 0.002 mg/g of exocarp fresh weight). Both secondary metabolites were not detected only in three species. The set-up methodology showed limits of quantification (LOQ) values, that were able to selectively quantify both GOFA and boropinic acid. Results described herein depict a potential chemopreventive dietary feeding role for the Rutaceae spp. under investigation.
authors.affiliation: Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, (CH), Italy, s.genovese@unich.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.forename: Marcello
authors.initials: M
authors.lastname: Locatelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carlucci
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry* / Q000145:classification*; D003373:Coumaric Acids / Q000737:chemistry*; D005069:Evaluation Studies as Topic; D057230:Limit of Detection; D009682:Magnetic Resonance Spectroscopy; D064209:Phytochemicals / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry
chemical_list: C552732:4'-geranyloxyferulic acid; D003373:Coumaric Acids; D064209:Phytochemicals; D010936:Plant Extracts