title: Reversibility of retinal microvascular changes in severe falciparum malaria.
abstract: Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Maude
authors.forename: Hugh W F
authors.initials: HWF
authors.lastname: Kingston
authors.forename: Sonia
authors.initials: S
authors.lastname: Joshi
authors.forename: Sanjib
authors.initials: S
authors.lastname: Mohanty
authors.forename: Saroj K
authors.initials: SK
authors.lastname: Mishra
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Arjen M
authors.initials: AM
authors.lastname: Dondorp
mesh_terms: D015822:Eye Infections, Parasitic / Q000469:parasitology / Q000473:pathology*; D006801:Humans; D007194:India; D016779:Malaria, Cerebral / Q000150:complications / Q000473:pathology*; D016778:Malaria, Falciparum / Q000150:complications / Q000473:pathology*; D008297:Male; D011859:Radiography; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000469:parasitology / Q000473:pathology*; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult