title: A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71.
abstract: Four glutarimide-derived compounds including a new 3-[2-[2-hydroxy-3-methylphenyl-5-(hydroxymethyl)]-2-oxoethyl] glutarimide (1) and three known 3-[2-(2-hyroxy-3,5- dimethylphenyl)-2-oxoethyl] glutarimide (2, actiphenol), 3-hydroxy-3-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl] glutarimide (3) and 3-[2-[2-hydroxy-3-(hydroxymethyl)-5-methylphenyl]-2-oxoethyl] glutarimide (4), along with a known indole alkaloid 3-(hydroxyacetyl) indole (5), were isolated from ethyl acetate extract of the fermentation broth of the marine sponge-derived Streptomyces anulatus S71. Their structures were deduced by extensive studies of NMR and mass spectra.
authors.affiliation: a State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240 , P.R. China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Yinxian
authors.initials: Y
authors.lastname: Yu
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.forename: Zixin
authors.initials: Z
authors.lastname: Deng
authors.forename: Shuangjun
authors.initials: S
authors.lastname: Lin
mesh_terms: D000818:Animals; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification*; D048630:Polyketide Synthases / Q000378:metabolism; D011161:Porifera / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C000594190:3-(2-(2-hydroxy-3-methylphenyl-5-(hydroxymethyl)-2-oxoethyl)glutarimide; C511572:3-(hydroxyacetyl)indole; D007211:Indoles; D010881:Piperidones; D048630:Polyketide Synthases; C007864:glutarimide
keywords: Streptomyces anulatus S71; actinomycete; glutarimide; marine sponge; polyketide synthase