title: B cell function and influenza vaccine responses in healthy aging and disease.
abstract: Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL 33136, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Frasca
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: bblomber@med.miami.edu.
authors.forename: Bonnie B
authors.initials: BB
authors.lastname: Blomberg
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines