title: Placental pathology and neonatal thrombocytopenia: lesion type is associated with increased risk.
abstract: OBJECTIVE
  To investigate the association between thrombocytopenia and placental lesions.
  
  
  METHODS
  Cases included singleton infants admitted to the intensive care unit (2005 to 2010) with platelet counts <100 000 μl(-1). We selected a contemporaneous control group matched for gestational age: 49 cases and 63 controls. The frequency of thrombosis in fetal vessels, fetal thrombotic vasculopathy, acute chorioamnionitis, chronic villitis, infarcts, hematomas, cord insertion and increased circulating nucleated red blood cells were identified on retrospective review of placental histology. Logistic regression models were used to test for associations.
  
  
  RESULTS
  Placental lesions associated with poor maternal perfusion (odds ratio (OR) 3.36, 95% confidence interval (CI) 1.38, 8.15) or affecting fetal vasculature (OR 2.75, 95% CI 1.05, 7.23), but not inflammation, were associated with thrombocytopenia. A Pearson Chi-Square Test for Independence for fetal and maternal lesions indicated that the two are independent factors.
  
  
  CONCLUSIONS
  Poor maternal perfusion and fetal vascular lesions are independently associated with thrombocytopenia in the newborn.
authors.affiliation: Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Litt
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Hecht
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D007752:Obstetric Labor, Premature / Q000473:pathology; D010920:Placenta / Q000098:blood supply* / Q000473:pathology*; D011225:Pre-Eclampsia / Q000473:pathology; D011247:Pregnancy; D012307:Risk Factors; D013921:Thrombocytopenia / Q000453:epidemiology*