title: Lack of sunlight exposure influence on primary glioblastoma survival.
abstract: BACKGROUND
  The prognosis of primary glioblastoma (GBM) is poor. Approximately 2/3 of primary brain tumor diagnoses are GBM, of which 95% are primary lesions. In this study, we aimed to evaluate whether more sunlight exposure has an effect on survival of patients with primary GBM.
  
  
  METHODS
  A total of 111 patients with primary GBM were enrolled from Kayseri in inner Anatolia which has a cold climate (n: 40) and Mersin in Mediterranean region with a warm climate and more sunlight exposure (n: 71). The patients with primary GBM were divided into two groups as Kayseri and Mersin and compared for progression free survival (PFS) and overall survival (OS).
  
  
  RESULTS
  The PFS values were 7.0 and 4.7 months for Kayseri and Mersin groups, respectively (p=0.10) and the respective OS values were 13.3 and 9.4 months (p=0.13). We did not found any significant difference regarding age, sex, comorbidity, smoking, surgery, resurgery, adjuvant chemoradiotherapy and palliative chemotherapy between the groups.
  
  
  CONCLUSIONS
  We found that more sunlight exposure had no impact on prognosis of patients with primary GBM, adding inconsistency to the literature about the relationship between sunlight and GBM.
authors.affiliation: Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey E-mail : doktorhasanmutlu@gmail.com.
authors.forename: Hasan
authors.initials: H
authors.lastname: Mutlu
authors.forename: Zeki
authors.initials: Z
authors.lastname: Akca
authors.forename: Abdulsamet
authors.initials: A
authors.lastname: Erden
authors.forename: Tuncay
authors.initials: T
authors.lastname: Aslan
authors.forename: Kadir
authors.initials: K
authors.lastname: Ucar
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kaplan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Buyukcelik
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D059186:Chemoradiotherapy, Adjuvant; D018572:Disease-Free Survival; D004781:Environmental Exposure; D005260:Female; D005843:Geography; D005909:Glioblastoma / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013472:Sunlight; D014421:Turkey; D014807:Vitamin D
chemical_list: D000970:Antineoplastic Agents; D014807:Vitamin D