title: Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer.
abstract: Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e and miR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.
authors.affiliation: Department of Cardio-Thoracic Surgery, Zhoushan Hospital , Zhoushan, Zhejiang , China ,1.
authors.forename: Wang-Yu
authors.initials: WY
authors.lastname: Zhu
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
authors.forename: Ji-Yuan
authors.initials: JY
authors.lastname: An
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: He
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Chen
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Xu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Huang
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Liu
authors.forename: Han-Bo
authors.initials: HB
authors.lastname: Le
authors.forename: Yong-Kui
authors.initials: YK
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D054337:Cell Dedifferentiation / Q000235:genetics; D018450:Disease Progression; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C531888:MIRN125 microRNA, human; D035683:MicroRNAs; C487931:mirnlet7 microRNA, human
keywords: Early detection; NSCLC; Prognosis; miRNA