title: Tau protein, beta-amyloid₁₋₄₂ and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia.
abstract: BACKGROUND
  Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB) are synucleinopathies. PDD and DLB are sometimes considered a transition between PD and Alzheimer dementia (AD). Finding in vivo markers or their combination could help in the differential diagnosis of these neurodegenerative (ND) diseases.
  
  
  OBJECTIVE
  The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau protein, betaamyloid1-42 and clusterin and to compare these levels among patients with probable PD, PDD, DLB and AD.
  
  
  METHODS
  CSF levels of ND markers were assessed in 96 patients (27 patients with PD, 14 with PDD, 14 with DLB, 17 with AD and 24 subjects as a control group).
  
  
  RESULTS
  In all of the groups of patients, beta-amyloid1-42 levels were decreasing in the order PD>PDD>DLB>AD, whereas tau protein and the tau protein/beta-amyloid1-42 index were increasing in the same order (PD<PDD<AD), except for DLB. In paired group comparisons, higher levels of clusterin in PD patients (p=0.005) and PDD patients (p=0.052) compared to the CG were found.
  
  
  CONCLUSIONS
  The results of the present study support the role of clusterin in PD pathogenesis. The decreasing CSF beta-amyloid1-42 levels in the order PDD, DLB and AD may relate to the increasing presence of AD pathology in these disorders.
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic. Electronic address: vranovaha@seznam.cz.
authors.forename: Hana Přikrylová
authors.initials: HP
authors.lastname: Vranová
authors.affiliation: Laboratory of Growth Regulator, Palacky University, Olomouc, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Hényková
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Michaela
authors.initials: M
authors.lastname: Kaiserová
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Menšíková
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Vaštík
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Mareš
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Hluštík
authors.affiliation: Faculty of Medicine and Dentistry, Department of Medical Biophysics, Palacky University, Olomouc, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Zapletalová
authors.affiliation: Laboratory of Growth Regulator, Palacky University, Olomouc, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Strnad
authors.affiliation: Faculty of Medicine and Dentistry, Department of Biochemistry, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Stejskal
authors.affiliation: Faculty of Medicine and Dentistry, Department of Neurology, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Kaňovský
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Alzheimer disease; Biomarkers; Cerebrospinal fluid; Clusterin; Lewy body dementia; Parkinson's disease