title: Novel concepts in HDL pharmacology.
abstract: High-density lipoproteins (HDL) are a target for drug development because of their proposed anti-atherogenic properties. In this review, we will briefly discuss the currently established drugs for increasing HDL-C, namely niacin and fibrates, and some of their limitations. Next, we will focus on novel alternative therapies that are currently being developed for raising HDL-C, such as CETP inhibitors. Finally, we will conclude with a review of novel drugs that are being developed for modulating the function of HDL based on HDL mimetics. Gaps in our knowledge and the challenges that will have to be overcome for these new HDL based therapies will also be discussed.
authors.affiliation: National Heart, Lung and Blood Institute, NIH, 10 Center Drive, Bldg. 10, Rm. 2C-433, Bethesda, MD, USA aremaley1@cc.nih.gov.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Remaley
authors.affiliation: Department of Pharmacological Sciences, Università degli Studi di Milano, Milano, Italy Center for the Study of Atherosclerosis, Società Italiana Studio Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Italy The Blizard Institute, Centre for Diabetes, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, UK.
authors.forename: Giuseppe D
authors.initials: GD
authors.lastname: Norata
authors.affiliation: Department of Pharmacological Sciences, Università degli Studi di Milano, Milano, Italy IRCCS Multimedica, Milan, Italy.
authors.forename: Alberico L
authors.initials: AL
authors.lastname: Catapano
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008076:Cholesterol, HDL / Q000097:blood*; D015195:Drug Design; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D058990:Molecular Targeted Therapy; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents
keywords: Atherosclerosis; Cardiovascular disease; Cholesterol; Drugs; HDL