title: The effects of stress on glutamatergic transmission in the brain.
abstract: Stress leads to detrimental effects on brain functions and results in various diseases. Recent studies highlight the involvement of glutamatergic transmission in pathogenesis of depressive behaviors and fears. Acute stress generates different impacts on the excitatory transmission compared to chronic stress. Different neuromodulators and epigenetic factors also participate in the alteration of synaptic transmission and the regulation of synaptic plasticity. Restoration of the glutamatergic transmission in stress-affected brain areas therefore provides novel directions of therapeutic interventions against stress.
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, China, ytf0707@126.com.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
authors.forename: Gonglin
authors.initials: G
authors.lastname: Hou
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018698:Glutamic Acid