title: Inappropriate antidiuretic hormone syndrome presenting as ectopic antidiuretic hormone-secreting gastric adenocarcinoma: a case report.
abstract: BACKGROUND
  Although the syndrome of inappropriate antidiuretic hormone has connection with various malignant tumors, there are few reports associated with advanced gastric cancer.
  
  
  METHODS
  We describe the case of a 63-year-old Korean male with inappropriate antidiuretic hormone syndrome due to an ectopic antidiuretic hormone-producing advanced gastric adenocarcinoma manifested with overt serum hypo-osmolar hyponatremia and high urinary sodium concentrations. His adrenal, thyroidal, and renal functioning were normal, and the hyponatremia improved following removal of the tumor. The cancer cells were immunostained and found to be positive for the antidiuretic hormone. To our knowledge, this is the first report of an antidiuretic hormone-secreting advanced gastric adenocarcinoma associated with the syndrome of inappropriate antidiuretic hormone, showing cancer cells immunostained for the antidiuretic hormone.
  
  
  CONCLUSIONS
  Although a strong relationship between gastric cancer and the syndrome of inappropriate antidiuretic hormone remains to be established, we suggest that gastric cancer could be included as a differential diagnosis of cancer that is associated with the syndrome of antidiuretic hormone.
authors.forename: Kyungo
authors.initials: K
authors.lastname: Hwang
authors.forename: Dae-Hong
authors.initials: DH
authors.lastname: Jeon
authors.forename: Ha Nee
authors.initials: HN
authors.lastname: Jang
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Bae
authors.forename: Jong Sil
authors.initials: JS
authors.lastname: Lee
authors.forename: Hyun Seop
authors.initials: HS
authors.lastname: Cho
authors.forename: Se-Ho
authors.initials: SH
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Gyeongsang National University, College of Medicine, 816 Beongil 15 Jinju-daero, Jinju, South Korea. drpdj@korea.com.
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Park
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology; D007150:Immunohistochemistry; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis / Q000209:etiology*; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins