title: Decreased motor function is associated with poorer cognitive function in elderly with type 2 diabetes.
abstract: OBJECTIVE
  Impaired motor function has been associated with cognitive impairment and dementia, but this relationship is poorly understood in elderly with type 2 diabetes (T2D). We thus investigated it in a large sample (n = 726) of cognitively normal elderly with T2D.
  
  
  METHODS
  In this cross-sectional study, hierarchical linear regressions assessed correlations of 3 motor measures (timed walk, grip strength, and self-reported motor difficulties) with episodic memory, attention/working memory, semantic categorization, executive function, and overall cognition controlling for demographics.
  
  
  RESULTS
  Longer timed walk and weaker grip strength were associated with poorer performance in all cognitive domains except episodic memory.
  
  
  CONCLUSIONS
  Associations of motor and cognitive functions in T2D and non-T2D samples are consistent. A lack of association of motor function with episodic memory may suggest non-Alzheimer's disease-related underlying mechanisms.
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Guerrero-Berroa
authors.affiliation: The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, USA.
authors.forename: Ramit
authors.initials: R
authors.lastname: Ravona-Springer
authors.affiliation: Maccabi Healthcare Services, University of Tel Aviv, Tel-Aviv, Israel ; Sackler Faculty of Medicine, University of Tel Aviv, Tel-Aviv, Israel.
authors.forename: Anthony
authors.initials: A
authors.lastname: Heymann
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA.
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA ; James J. Peters Veterans Affairs Medical Center, Bronx, N.Y., USA.
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA ; James J. Peters Veterans Affairs Medical Center, Bronx, N.Y., USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Sano
authors.affiliation: The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, USA.
authors.forename: Keren
authors.initials: K
authors.lastname: Koifmann
authors.affiliation: Maccabi Healthcare Services, University of Tel Aviv, Tel-Aviv, Israel.
authors.forename: Rachel
authors.initials: R
authors.lastname: Preiss
authors.affiliation: Maccabi Healthcare Services, University of Tel Aviv, Tel-Aviv, Israel.
authors.forename: Hadas
authors.initials: H
authors.lastname: Hoffman
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA ; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, USA.
authors.forename: Michal
authors.initials: M
authors.lastname: Schnaider Beeri
keywords: Cognition; Dementia; Elderly; Memory; Motor function; Type 2 diabetes