title: Increased prevalence of chronic lymphocytic thyroiditis in Korean patients with papillary thyroid cancer.
abstract: BACKGROUND
  In recent years, some reports have suggested that papillary thyroid cancers are more frequently associated with lymphocytic thyroiditis or Hashimoto's thyroiditis. This study investigated a potential increase in the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients.
  
  
  METHODS
  We used national epidemiological survey data on thyroid cancer patients diagnosed in 1999, 2005, and 2008. A retrospective medical record survey was conducted by representative sampling of a national cancer incidence database. The analysis included 5,378 papillary thyroid cancer patients aged 20-79 years. We calculated the age-standardized prevalence and age-adjusted prevalence ratios using a binomial regression model with a log link for the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients by sex for each year.
  
  
  RESULTS
  The prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients was 4.0% and 12.8% for men and women in 1999, 6.5% and 24.6% in 2005, and 10.7% and 27.6% in 2008, respectively. Between 1999 and 2008, the age-standardized prevalence of chronic lymphocytic thyroiditis increased 4.1-fold in male patients and 2.0-fold in female patients with papillary thyroid cancer. The prevalence of other thyroid diseases, however, did not increase in either gender.
  
  
  CONCLUSIONS
  Among Korean papillary thyroid cancer patients, the prevalence of chronic lymphocytic thyroiditis increased between 1999 and 2008, whereas the prevalence of other thyroid disorders did not change.
authors.affiliation: National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Oh
authors.affiliation: Department of Epidemiology and Health Promotion, Yonsei University, Graduate School of Public Health, Seoul, Korea.
authors.forename: Sohee
authors.initials: S
authors.lastname: Park
authors.affiliation: National Emergency Medical Center, National Medical Center, Seoul, Korea.
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Won
authors.affiliation: Department of Preventive Medicine, Seoul National University, College of Medicine, Seoul, Korea.
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.affiliation: National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Kong
authors.affiliation: National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Kui-Sun
authors.initials: KS
authors.lastname: Choi
authors.affiliation: Center for Thyroid Cancer, National Cancer Center, Goyang, Korea.
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Division of endocrine surgery, Department of surgery, Asan Medical Center, Seoul, Korea.
authors.forename: Ki-Wook
authors.initials: KW
authors.lastname: Chung
authors.affiliation: National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Kyu-Won
authors.initials: KW
authors.lastname: Jung
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000150:complications* / Q000473:pathology; D002291:Carcinoma, Papillary; D005260:Female; D050031:Hashimoto Disease / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012737:Sex Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology; D055815:Young Adult