title: Iodine-catalyzed aromatization of tetrahydrocarbazoles and its utility in the synthesis of glycozoline and murrayafoline A: a combined experimental and computational investigation.
abstract: A new protocol for the aromatization of tetrahydrocarbazoles has been achieved using a catalytic amount of iodine, giving high yields. The role of iodine in the aromatization has been explained by DFT, and its wide scope is extended to the total synthesis of glycozoline and murrayafoline A. This method has proven to be tolerant of a broad range of functional groups.
authors.affiliation: Center for Advance Studies, Department of Chemistry, University of Pune, Pune, 411007, India. vivekhumne@rediffmail.com pdlokhande@chem.unichem.ac.in.
authors.forename: Vivek
authors.initials: V
authors.lastname: Humne
authors.forename: Yuvraj
authors.initials: Y
authors.lastname: Dangat
authors.forename: Kumar
authors.initials: K
authors.lastname: Vanka
authors.forename: Pradeep
authors.initials: P
authors.lastname: Lokhande
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003196:Computer Graphics; D007455:Iodine / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002227:Carbazoles; C443728:murrayafoline A; C034053:glycozoline; D007455:Iodine