title: Transcript maturation in apicomplexan parasites.
abstract: The complex life cycles of apicomplexan parasites are associated with dynamic changes of protein repertoire. In Toxoplasma gondii, global analysis of gene expression demonstrates that dynamic changes in mRNA levels unfold in a serial cascade during asexual replication and up to 50% of encoded genes are unequally expressed in development. Recent studies indicate transcription and mRNA processing have important roles in fulfilling the 'just-in-time' delivery of proteins to parasite growth and development. The prominence of post-transcriptional mechanisms in the Apicomplexa was demonstrated by mechanistic studies of the critical RNA-binding proteins and regulatory kinases. However, it is still early in our understanding of how transcription and post-transcriptional mechanisms are balanced to produce adequate numbers of specialized forms that is required to complete the parasite life cycle.
authors.affiliation: Center for Drug Discovery and Innovation, University South Florida, Tampa, FL 33612, United States. Electronic address: essuvorova@gmail.com.
authors.forename: Elena S
authors.initials: ES
authors.lastname: Suvorova
authors.affiliation: Department of Global Health, University South Florida, Tampa, FL 33612, United States.
authors.forename: Michael W
authors.initials: MW
authors.lastname: White
mesh_terms: D016782:Apicomplexa / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger