title: Cell-penetrating peptide-mediated topical delivery of biomacromolecular drugs.
abstract: Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.
authors.forename: Jiao
authors.initials: J
authors.lastname: Tan
authors.forename: Heesun
authors.initials: H
authors.lastname: Cheong
authors.forename: Yoon Shin
authors.initials: YS
authors.lastname: Park
authors.forename: Hangun
authors.initials: H
authors.lastname: Kim
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Cheol
authors.initials: C
authors.lastname: Moon
authors.affiliation: College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 540- 950, Republic of Korea. cheolm@sunchon.ac.kr.
authors.forename: Yongzhuo
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000818:Animals; D001692:Biological Transport; D057846:Cell-Penetrating Peptides / Q000008:administration & dosage* / Q000145:classification; D016503:Drug Delivery Systems; D006801:Humans; D046911:Macromolecular Substances / Q000008:administration & dosage*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage
chemical_list: D057846:Cell-Penetrating Peptides; D046911:Macromolecular Substances; D004364:Pharmaceutical Preparations