title: Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria.
abstract: BACKGROUND
  Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research.
  
  
  OBJECTIVE
  An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials.
  
  
  METHODS
  A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place.
  
  
  RESULTS
  The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed.
  
  
  CONCLUSIONS
  Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.
authors.affiliation: Neuroimmunology and MS Research Section, University Hospital Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Schippling
authors.affiliation: MS Centre Amsterdam, VU University Medical Centre, The Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: Balk
authors.affiliation: University of Calgary, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Costello
authors.affiliation: Medical Faculty, Heinrich-Heine University Düsseldorf, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Albrecht
authors.affiliation: New York University School of Medicine, New York, USA.
authors.forename: L
authors.initials: L
authors.lastname: Balcer
authors.affiliation: Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Calabresi
authors.affiliation: University of Copenhagen, Denmark.
authors.forename: J L
authors.initials: JL
authors.lastname: Frederiksen
authors.affiliation: University of Texas Southwestern Medical Center at Dallas, USA.
authors.forename: E
authors.initials: E
authors.lastname: Frohman
authors.affiliation: MS Center, University of California San Francisco, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Green
authors.affiliation: Save Sight Institute, University of Sydney, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Klistorner
authors.affiliation: University of Lille Nord de France, France.
authors.forename: O
authors.initials: O
authors.lastname: Outteryck
authors.affiliation: NeuroCure Clinical Research Center (NCRC) and Clinical and Experimental MS Research Center, Charite, Universitätsmedizin Berlin, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Paul
authors.affiliation: Moorfields Eye Hospital, The National Hospital for Neurology and Neurosurgery and St. Thomas' Hospital, London, UK.
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
authors.affiliation: University Hospital Zurich, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Traber
authors.affiliation: University of Lille Nord de France, France.
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
authors.affiliation: Center for Neuroimmunology, Institute of Biomedical Research August, Pi Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Villoslada
authors.affiliation: Bern University Hospital and University of Bern, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Wolf
authors.affiliation: MS Centre Amsterdam, VU University Medical Centre, The Netherlands a.petzold@vumc.nl.
authors.forename: A
authors.initials: A
authors.lastname: Petzold
mesh_terms: D001284:Atrophy / Q000473:pathology; D006801:Humans; D009103:Multiple Sclerosis / Q000473:pathology*; D011446:Prospective Studies; D011786:Quality Control; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000592:standards*
keywords: Atrophy; multiple sclerosis; outcome measurement; progressive