title: Synthesis of heterocycles through transition-metal-catalyzed isomerization reactions.
abstract: Metal-catalyzed isomerization of N- and O-allylic systems is emerging as an effective method to form synthetically useful iminium and oxocarbenium intermediates. In the presence of tethered nucleophiles, several recent examples illuminate this approach as a powerful strategy for the synthesis of structurally complex and diverse heterocycles. In this Concept article, we attempt to cover this area of research through a selection of recent versatile examples.
authors.affiliation: Department of Chemistry, Technical University of Denmark, Kemitorvet, Build. 201, 2800 Kgs. Lyngby (Denmark), Fax: (+45) 45-88-31-36.
authors.forename: Mette
authors.initials: M
authors.lastname: Ishoey
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Nielsen
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D008670:Metals / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D006571:Heterocyclic Compounds; D008670:Metals; D028561:Transition Elements
keywords: allylic compounds; dual catalysis; heterocycles; iminium; isomerization