title: A systematic analysis of miRNA-mRNA paired variations reveals widespread miRNA misregulation in breast cancer.
abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate gene expression by binding to target mRNAs and induce translation repression or RNA degradation. There have been many studies indicating that both miRNAs and mRNAs display aberrant expression in breast cancer. Previously, most researches into the molecular mechanism of breast cancer examined miRNA expression patterns and mRNA expression patterns separately. In this study, we systematically analysed miRNA-mRNA paired variations (MMPVs), which are miRNA-mRNA pairs whose pattern of regulation can vary in association with biopathological features, such as the oestrogen receptor (ER), TP53 and human epidermal growth factor receptor 2 (HER2) genes, survival time, and breast cancer subtypes. We demonstrated that the existence of MMPVs is general and widespread but that there is a general unbalance in the distribution of MMPVs among the different biopathological features. Furthermore, based on studying MMPVs that are related to multiple biopathological features, we propose a potential crosstalk mechanism between ER and HER2.
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Bioinformatics, Harbin Medical University, Harbin 150081, China.
authors.forename: Kuixi
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of Bioinformatics, Harbin Medical University, Harbin 150081, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Jin
authors.affiliation: Department of Bioinformatics, Harbin Medical University, Harbin 150081, China.
authors.forename: Deng
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Baoliang
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Zhaoqi
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Internal Medicine, Cancer Hospital Affiliated to Harbin Medical University, Harbin 150040, China.
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000096:biosynthesis; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D047628:Estrogen Receptor alpha; D035683:MicroRNAs; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53; C506487:ESR1 protein, human; C495901:TP53 protein, human; C508053:ERBB2 protein, human