title: White matter changes with age utilizing quantitative diffusion MRI.
abstract: OBJECTIVE
  To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI.
  
  
  METHODS
  Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data.
  
  
  RESULTS
  Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years.
  
  
  CONCLUSIONS
  We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN. lauriebaker@umsl.edu.
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Baker
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: David H
authors.initials: DH
authors.lastname: Laidlaw
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Conturo
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Joseph
authors.initials: J
authors.lastname: Hogan
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Xi
authors.initials: X
authors.lastname: Luo
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Stephen
authors.initials: S
authors.lastname: Correia
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Ryan
authors.initials: R
authors.lastname: Cabeen
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Lane
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Jodi M
authors.initials: JM
authors.lastname: Heaps
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Jacob
authors.initials: J
authors.lastname: Bolzenius
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Salminen
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Erbil
authors.initials: E
authors.lastname: Akbudak
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Amanda R
authors.initials: AR
authors.lastname: McMichael
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Christina
authors.initials: C
authors.lastname: Usher
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Ashley
authors.initials: A
authors.lastname: Behrman
authors.affiliation: From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Paul
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009434:Neural Pathways / Q000473:pathology; D013788:Thalamus / Q000473:pathology; D013997:Time Factors