title: Prevalence of metabolic syndrome in the family members of women with polycystic ovary syndrome from North India.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is the most complex and common endocrine disorder of women in reproductive years. In addition to irregular menstrual cycles, chronic anovulation and hyperandrogenism, it has many metabolic manifestations such as obesity, hyperlipidemia, hyperinsulinemia, insulin resistance, dysglycemia, increased risk of cardiovascular disease or possibly endometrial cancer. Familial clustering of PCOS in consistence with the genetic susceptibility has been described.
  
  
  METHODS
  The present study assessed the clinical, biochemical and hormonal parameters including prevalence of metabolic syndrome by two different criteria in the first- degree relatives of patients with PCOS.
  
  
  RESULTS
  The average age of 37 index patients was 23 ± 3.6 years, with the mean age of menarche as 13.3 ± 1.2 years. The mean age and age of menarche in mothers (n = 22) was 48.8 ± 5.1 and 13 ± 1.3 years, respectively, whereas as it was 23.5 ± 4.7 and 13.3 ± 1.2 years in sisters (n = 22), respectively. Metabolic syndrome (MS) defined by International Diabetes Federation (IDF) criteria was present in 10 index patients, 1 brother, 4 sisters, 17 mothers and 15 fathers while as by Adult Treatment Panel III (ATP III) it was in 8 index patients, 5 sisters, 16 mothers and 11 fathers.
  
  
  CONCLUSIONS
  The presence of MS or related metabolic derangements is high in the family members of women with PCOS.
authors.affiliation: PhD Scholar, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Iram
authors.initials: I
authors.lastname: Shabir
authors.affiliation: Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ganie
authors.affiliation: Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Mohd Afzal
authors.initials: MA
authors.lastname: Zargar
authors.affiliation: Department of Clinical Biochemistry, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Dilafroz
authors.initials: D
authors.lastname: Bhat
authors.affiliation: Department of Clinical Biochemistry, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Mohd Muzzafar
authors.initials: MM
authors.lastname: Mir
authors.affiliation: Department of Hematology, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Aleem
authors.initials: A
authors.lastname: Jan
authors.affiliation: Department of Immunology and Molecular Medicine, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Zaffar Amin
authors.initials: ZA
authors.lastname: Shah
authors.affiliation: Department of Cardiology, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Vicar
authors.initials: V
authors.lastname: Jan
authors.affiliation: Department of Radiodiagnosis, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Riyaz
authors.initials: R
authors.lastname: Rasool
authors.affiliation: Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Andleeb
authors.initials: A
authors.lastname: Naqati
keywords: Adult treatment panel iii; insulin resistance; international diabetes federation; metabolic syndrome; polycystic ovary syndrome