title: The prevalence of human papilloma virus (HPV) infections in oral squamous cell carcinomas: a retrospective analysis of 88 patients and literature overview.
abstract: In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains still uncertain. In this study, we analysed the HPV status in 88 consecutive patients with OSCCs localized anterior of the palatoglossal arch who were treated in the Department of Oral and Maxillofacial Surgery at the University Medical Center Mainz. The HPV status analysis was performed using DNA-PCR and immunostaining of p16 protein. The prevalence of HPV-positive OSCCs was about 6% (5 patients). In 3 patients the HPV subtypes 16/18 were found. No significant differences between the HPV positive and negative patients regarding age, gender, smoking and alcohol consumption, localization and TNM level could be detected. Contrary to other studies focussing on cancers of the lingual and palatine tonsil, the prevalence of HPV infections was much lower in the oral cavity. Therefore HPV infection might play a less important role in oral carcinogenesis.
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany. Electronic address: maximilian.krueger@unimedizin-mainz.de.
authors.forename: M
authors.initials: M
authors.lastname: Krüger
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Pabst
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Walter
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Sagheb
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Günther
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Blatt
authors.affiliation: Institute of Virology (Head: Univ. Prof. Dr. M.J. Reddehase), University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Weise
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Al-Nawas
authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Ziebart
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology; D052685:Alphapapillomavirus / Q000502:physiology*; D063646:Carcinogenesis; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000821:virology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D052162:Human papillomavirus 16 / Q000502:physiology; D052161:Human papillomavirus 18 / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000821:virology*; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult
keywords: HPV; Human papilloma virus; Oral squamous cell carcinoma; Prevalence