title: Does machine perfusion decrease ischemia reperfusion injury?
abstract: In 1990's, use of machine perfusion for organ preservation has been abandoned because of improvement of preservation solutions, efficient without perfusion, easy to use and cheaper. Since the last 15 years, a renewed interest for machine perfusion emerged based on studies performed on preclinical model and seems to make consensus in case of expanded criteria donors or deceased after cardiac death donations. We present relevant studies highlighted the efficiency of preservation with hypothermic machine perfusion compared to static cold storage. Machines for organ preservation being in constant evolution, we also summarized recent developments included direct oxygenation of the perfusat. Machine perfusion technology also enables organ reconditioning during the last hours of preservation through a short period of perfusion on hypothermia, subnormothermia or normothermia. We present significant or low advantages for machine perfusion against ischemia reperfusion injuries regarding at least one primary parameter: risk of DFG, organ function or graft survival.
authors.affiliation: Inserm U1082, Poitiers F-86021, France ; université de Poitiers, faculté de Médecine et de Pharmacie, F-86034 Poitiers, France.
authors.forename: D
authors.initials: D
authors.lastname: Bon
authors.affiliation: Inserm U1082, Poitiers F-86021, France ; université de Poitiers, faculté de Médecine et de Pharmacie, F-86034 Poitiers, France; Service d'Urologie, CHU La Miletrie, 86000 Poitiers, France.
authors.forename: P-O
authors.initials: PO
authors.lastname: Delpech
authors.affiliation: Service d'Urologie, CHU La Miletrie, 86000 Poitiers, France.
authors.forename: N
authors.initials: N
authors.lastname: Chatauret
authors.affiliation: Inserm U1082, Poitiers F-86021, France ; université de Poitiers, faculté de Médecine et de Pharmacie, F-86034 Poitiers, France. Electronic address: t.hauet@chu-poitiers.fr.
authors.forename: T
authors.initials: T
authors.lastname: Hauet
authors.affiliation: Inserm U1082, Poitiers F-86021, France ; université de Poitiers, faculté de Médecine et de Pharmacie, F-86034 Poitiers, France; Service d'Urologie, CHU Edouard Herriot, 69000 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Badet
authors.affiliation: Inserm U1082, Poitiers F-86021, France ; université de Poitiers, faculté de Médecine et de Pharmacie, F-86034 Poitiers, France; Service d'Urologie, Service de Transplantation rénale et pancréatique, CHU la Pitié Salpêtrière, AP-HP, 75013 Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Barrou
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000295:instrumentation* / Q000379:methods*; D010477:Perfusion / Q000295:instrumentation*; D015427:Reperfusion Injury / Q000517:prevention & control*
keywords: Ischemia-reperfusion; Ischémie-reperfusion; Machine de perfusion; Machine perfusion; Transplantation