title: Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters.
abstract: A series of phosphaisocoumarin amidates were synthesized for the first time via DIBAL-H-mediated direct amidation of phosphaisocoumarin esters under mild conditions in good to excellent yields. The present reaction showed high selectivity. In each case, the phostone ring was intact and only the exocyclic ethoxy group was amidated. A plausible mechanism of the reaction was provided.
authors.affiliation: School of Chemistry & Chemical Engineering, Sun Yat-sen University, 135 Xingangxi Lu, Guangzhou, 510275, China. cespay@mail.sysu.edu.cn.
authors.forename: Yu-Juan
authors.initials: YJ
authors.lastname: Guo
authors.forename: Pei-Jiang
authors.initials: PJ
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Ai-Yun
authors.initials: AY
authors.lastname: Peng
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D049934:Isocoumarins / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000588:Amines; D004952:Esters; D049934:Isocoumarins; D009942:Organometallic Compounds; D063065:Organophosphonates; C035719:diisobutylaluminum