title: [Studying of cytokine dynamics in injured persons with severe burns for estimation of severity and prognosis].
abstract: Dynamics of a blood serum concentration of tumor necrosis factor-alpha (TNF- alpha), interleukines (IL-1beta, IL-10) in 35 patients, suffering severe burn, and possibility of application of these indices as biomarkers of the severity state and the complications prognosis, were studied. During the investigation there was established, that TNF-alpha concentration on the 8 - 10th and 19 - 21th day after trauma does the best for characterization of a burn total area, while the IL-1beta concentration on the 8 - 10th day after trauma - the deep affections severity and the IL-10 concentration on the 19 - 21th day after trauma - the deep affections severity. Hyperreactivity, caused by enhanced production of TNF-alpha, IL-1beta and IL-10, witnesses the raised risk of development of the organs complications. And adversely, hypo- and areactivity in extended and deep burns witnesses about enhanced risk of lethality. The blood serum concentration of TNF-alpha, IL-1beta and IL-10 is expedient to use as a biomarkers of the patients state severity and for the course prognosis of pathological process.
authors.forename: O M
authors.initials: OM
authors.lastname: Kovalenko
authors.forename: D V
authors.initials: DV
authors.lastname: Mal'tsev
authors.forename: V Ie
authors.initials: VIe
authors.lastname: Kazmirchuk
authors.forename: A O
authors.initials: AO
authors.lastname: Kovalenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D003627:Data Interpretation, Statistical; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D007700:Kinetics; D008875:Middle Aged; D011379:Prognosis; D015599:Trauma Severity Indices; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; C508585:IL1B protein, human; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10