title: [Predictive value of HLA-DRB1 gene for the treatment of unexplained recurrent spontaneous abortion with paternal lymphocyte alloimmunization therapy in Henan Hans].
abstract: OBJECTIVE
  To explore the value of HLA-DRB1 gene in predicting the outcome of unexplained recurrent spontaneous abortion (URSA) treated with paternal lymphocyte alloimmunization therapy (PLAT) in Henan Hans.
  
  
  METHODS
  Three hundred URSA patients were recruited. Following PLAT treatment, they were divided into two groups according to the outcome of pregnancy. Polymerase chain reaction sequence specific primer (PCR-SSP) were conducted to analyze the HLA-DRB1 gene.
  
  
  RESULTS
  For those who have received PLAT treatment, the frequency of HLA-DRB1*11 was significantly lower in successfully treated cases than those with abortion (0.052 vs. 0.110, P < 0.05, OR=0448), whilst the frequency of HLA-DRB1*15 was significantly greater in the former (0.207 vs. 0.100, P < 0.05, OR=2.352).
  
  
  CONCLUSIONS
  For patients who have received PLAT treatment, those with HLA-DRB1*15 are more likely to conceive that those with HLA-DRB1*11.
authors.affiliation: Medical Genetics Institute of Henan Province, Peoples Hospital of Henan Province, Peoples Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China. Email: ykxiedi1986124@163.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Shixiu
authors.initials: S
authors.lastname: Liao
authors.forename: Miao
authors.initials: M
authors.lastname: He
authors.forename: Yan
authors.initials: Y
authors.lastname: Chu
authors.forename: Qiancheng
authors.initials: Q
authors.lastname: Li
authors.forename: Qiannan
authors.initials: Q
authors.lastname: Guo
authors.forename: Qiaofang
authors.initials: Q
authors.lastname: Hou
authors.forename: Xuebing
authors.initials: X
authors.lastname: Ding
mesh_terms: D000022:Abortion, Spontaneous / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D007167:Immunotherapy; D007519:Isoantigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D059811:HLA-DRB1 Chains; D007519:Isoantigens