title: Death by water: precautionary water submersion for intravitreal injection of retinoblastoma eyes.
abstract: There is growing interest in intravitreal injections of chemotherapy for retinoblastoma. However, concerns for potential tumor seeding through the needle track has prompted the use of risk-reducing precautionary methods. Presented here is a novel technique, which can be easily replicated, requires minimal sophisticated equipment and with laboratory data supporting its concept. Sterile distilled water submersion for 3 minutes renders retinoblastoma cells nonviable and can be employed as a precautionary method following intravitreal injection in the technique described here.
authors.affiliation: Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Jasmine H
authors.initials: JH
authors.lastname: Francis
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Xiaoliang L
authors.initials: XL
authors.lastname: Xu
authors.affiliation: Service of Interventional Neuroradiology, Departments of Neurosurgery, Neurology and Radiology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA.
authors.forename: Y Pierre
authors.initials: YP
authors.lastname: Gobin
authors.affiliation: Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA ; Department of Ophthalmology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Marr
authors.affiliation: Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Brodie
authors.affiliation: Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA ; Department of Ophthalmology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Abramson
keywords: Cancer; chemotherapy; distilled water; fine needle aspiration; intravitreal injection; melphalan; retinoblastoma; water.