title: Clinical and neuroimaging findings in neonatal herpes simplex virus infection.
abstract: In a retrospective review of infants with neonatal herpes simplex virus disease (n=29), we found bilateral multilobar (n=8), pontine (n=3), thalamic (n=6), and internal capsule and corticospinal tract (n=5) involvement on magnetic resonance imaging (MRI). Diffusion-weighted imaging (n=6) performed early revealed additional involvement than detected by conventional MRI. Neurodevelopmental sequelae were correlated with MRI abnormalities. Our findings demonstrate that MRI, including diffusion-weighted imaging, is a valuable prognostic adjunct in neonatal herpes simplex virus disease.
authors.affiliation: Carman and Ann Department of Pediatrics, Wayne State University, Detroit, MI. Electronic address: mbajaj@dmc.org.
authors.forename: Monika
authors.initials: M
authors.lastname: Bajaj
authors.affiliation: Department of Radiology, Wayne State University, Detroit, MI.
authors.forename: Swati
authors.initials: S
authors.lastname: Mody
authors.affiliation: Carman and Ann Department of Pediatrics, Wayne State University, Detroit, MI.
authors.forename: Girija
authors.initials: G
authors.lastname: Natarajan
mesh_terms: D001921:Brain / Q000473:pathology*; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis*; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies; D018139:Simplexvirus / Q000302:isolation & purification*