title: [Clinical analysis of 56 patients with cervical cancer after cold knife conization].
abstract: OBJECTIVE
  To evaluate the clinical value of conization in the diagnosis of cervical cancer to optimize its management.
  
  
  METHODS
  Fifty-six patients diagnosed with cervical cancer after conization at our hospital between 2008 and 2012 were reviewed. The pathological profiles of colposcopic multiple biopsies and treatment options were analyzed.
  
  
  RESULTS
  Among them, there were stage Ia1 (n = 39), stage Ia2 (n = 2) and stage Ib1 (n = 15). And there was not much correspondence between cervical conization and colposcopic multiple biopsies in 46 cases. Among 23 patients with stage Ia1 undergoing further surgery, 12 (52.17%) had residual diseases, including CINI (n = 5), CINII(n = 3), CINIII (n = 3). No recurrence was found in 16 cases without further surgical intervention. All cases of stages Ia2 and Ib1 underwent repeat surgery while 8 cases received preoperative chemotherapy, including stage Ia2 (n = 1) and stage Ib2 (n = 7).
  
  
  CONCLUSIONS
  Cold knife conization plays a very important role in the diagnosis and treatment of cervical diseases. Further treatment options should be selected individually and comprehensively based on such factors as patient age, degrees of dysplasia, surgical margin status, fertility requirements and so on.
authors.affiliation: Department of Obstetrics & Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynecology, Peking University People's Hospital, Beijing 100044, China. Email: wangjianliu@pkuph.edu.cn.
authors.forename: Jianliu
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D003080:Cold Temperature; D019092:Conization / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology / Q000601:surgery