title: Unlocking epigenetic codes in neurogenesis.
abstract: During embryonic and adult neurogenesis, neuronal stem cells follow a highly conserved path of differentiation to give rise to functional neurons at various developmental stages. Epigenetic regulation--including DNA modifications, histone modifications, and noncoding regulatory RNAs, such as microRNA (miRNA) and long noncoding RNA (lncRNA)--plays a pivotal role in embryonic and adult neurogenesis. Here we review the latest in our understanding of the epigenetic regulation in neurogenesis, with a particular focus on newly identified cytosine modifications and their dynamics, along with our perspective for future studies.
authors.affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Yao
authors.affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000196:embryology / Q000294:innervation; D044127:Epigenesis, Genetic; D005815:Genetic Code / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans; D055495:Neurogenesis / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional
chemical_list: D006657:Histones
keywords: DNA modifications; epigenetics; histone modifications; neurogenesis; noncoding RNAs