title: Comparison of the pharmacokinetics of linezolid in burn and non-burn rabbits.
abstract: Linezolid is effective on many resistant organisms for the treatment of severe infections in burns. However, its pharmacokinetics was difficult to predict after major burns. The study aimed to describe the pharmacokinetic properties of linezolid administered intravenously at a dose of 10 mg/kg in severely burned rabbits in comparison to that in non-burns. Linezolid concentrations were quantitatively analyzed by high-performance liquid chromatography. The direct consequence of the physiological changes after burn injury was lower plasma linezolid concentrations. In addition, burn injury induced significantly altered pharmacokinetic parameters with higher inter-individual variability. The distribution volume and clearance rate were increased (2.88 vs. 1.92 L/kg, P > 0.05; 0.28 vs. 0.20 L/h/kg, P < 0.05), and the AUC0-∞ was significantly lower (37.99 vs. 51.47 mg/L h, P < 0.05). However, there were almost no changes in half-life and mean residence time. These results suggested that therapeutic drug monitoring and dosage individualization of linezolid in patients with severe burns were necessary.
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of General Hospital of PLA, 51 Fucheng Road, Beijing, 100048, China, jianli.ma@hotmail.com.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Wan-Li
authors.initials: WL
authors.lastname: Chu
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Feng
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Wang
authors.forename: Qing-Zhe
authors.initials: QZ
authors.lastname: Zhang
mesh_terms: D061605:Administration, Intravenous / Q000379:methods; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002056:Burns / Q000378:metabolism* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D006207:Half-Life; D000069349:Linezolid / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011817:Rabbits
chemical_list: D000900:Anti-Bacterial Agents; D000069349:Linezolid