title: Reducing the incidence of chronic lung disease in very premature infants with aminophylline.
abstract: BACKGROUND
  The objective of this study is to assess the safety and preventative effects of aminophylline on the incidence of chronic lung disease (CLD) in very premature infants.
  
  
  METHODS
  This was a long follow-up randomized clinical trial. The prophylactic effect of aminophylline on the incidence of CLD was investigated in very premature infants. The study group received aminophylline for the 1(st) 10 days of life and control infants received no aminophylline during the 1(st) 10 days of life.
  
  
  RESULTS
  Fifty-two infants participated (26 aminophylline, 26 controls). Premature infants on aminophylline had clearly shorter oxygen dependency time than those in the control group. Median time of oxygen dependency was 3 (0-9.5) days and 14 (3-40.5) days in group A and C, respectively (P: 0.001). Incidence of CLD was significantly different between the two groups. Only two infants (8.7%) on aminophylline developed CLD, when compared to 11 infants (44.0%), who did not receive aminophylline (P: 0.006). No side-effects were reported in the neonates (P: 1).
  
  
  CONCLUSIONS
  This study supports the preventative effects of aminophylline on the incidence of CLD in very premature infants. In other words, the more premature the infants, the greater will be the preventative effect of aminophylline on the incidence of CLD.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Amir-Mohammad
authors.initials: AM
authors.lastname: Armanian
authors.affiliation: Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Badiee
authors.affiliation: Department of Pediatrics, Division of Neonatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Raha
authors.initials: R
authors.lastname: Afghari
authors.affiliation: Almahdi University, Isfahan, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Salehimehr
authors.affiliation: Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Hassanzade
authors.affiliation: Department of Pediatrics, Division of Neonatology, Alzahra Hospital NICU, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Soghra
authors.initials: S
authors.lastname: Sheikhzadeh
authors.affiliation: Alzahra Hospital Neonatal Unit, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Shariftehrani
authors.affiliation: Shahid Beheshti Hospital NICU, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Gohar
authors.initials: G
authors.lastname: Rezvan
keywords: Aminophylline; chronic lung disease; preterm neonates; prevention