title: Survivin suppression through STAT3/β-catenin is essential  for resveratrol-induced melanoma apoptosis.
abstract: Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell lines, we show that survivin is essential for melanoma survival in vitro and in vivo and is targeted by resveratrol. Furthermore, we identify the down regulation of survivin transcription by resveratrol through the suppression of β-catenin and STAT3. In addition, over expression of survivin protects melanoma cells from resveratrol-induced apoptosis. Collectively, these studies establish that targeting survivin could provide an opportunity to treat melanoma patients.
authors.lastname: Habibie
authors.forename: Satoru
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Sherif
authors.initials: S
authors.lastname: Abdelhamed
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakurai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saiki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D047369:Chromatin Immunoprecipitation; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D060888:Real-Time Polymerase Chain Reaction; D000077185:Resveratrol; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013267:Stilbenes / Q000494:pharmacology*; D000077022:Survivin; D023041:Xenograft Model Antitumor Assays; D051176:beta Catenin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D050796:STAT3 Transcription Factor; D013267:Stilbenes; D000077022:Survivin; D051176:beta Catenin; D000077185:Resveratrol