title: Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.
abstract: Preclinical models for colorectal cancer (CRC) are critical for translational biology and drug development studies to characterize and treat this condition. Mouse models of human cancer are particularly popular because of their relatively low cost, short life span, and ease of use. Genetically engineered mouse models (GEMMs) of CRC are engineered from germline or somatic modification of critical tumor suppressor genes and/or oncogenes that drive mutations in human disease. Detailed in this overview are the salient features of several useful colorectal cancer GEMMs and their value as tools for translational biology and preclinical drug development.
authors.affiliation: Division of Gastroenterology and Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts.
authors.forename: Jatin
authors.initials: J
authors.lastname: Roper
authors.forename: Eric S
authors.initials: ES
authors.lastname: Martin
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Hung
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics*; D004195:Disease Models, Animal; D055808:Drug Discovery; D052138:Genes, Neoplasm / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D009368:Neoplasm Transplantation / Q000379:methods; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000235:genetics*; D057170:Translational Research, Biomedical
keywords: cancer models; colorectal cancer; genetically engineered mouse models; orthotopic transplantation