title: Etiology of leukocyte adhesion deficiency-associated periodontitis revisited: not a raging infection but a raging inflammatory response.
abstract: In leukocyte adhesion deficiency type I, neutrophils fail to adhere to blood vessel walls and thus cannot transmigrate to peripheral tissues. Leukocyte adhesion deficiency type I patients invariably experience an aggressive form of generalized periodontitis, which has been historically attributed to defective neutrophil surveillance of the periodontal infection. This time-honored notion has now been challenged by a recent study, which showed that the underlying etiology involves a dysregulated host response that leads to overexpression of the proinflammatory and bone-resorptive cytokine IL-17.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.
authors.forename: George
authors.initials: G
authors.lastname: Hajishengallis
authors.forename: Niki M
authors.initials: NM
authors.lastname: Moutsopoulos
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D001862:Bone Resorption; D002633:Chemotaxis; D004195:Disease Models, Animal; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000150:complications / Q000276:immunology*; D051379:Mice; D058990:Molecular Targeted Therapy; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology; D010518:Periodontitis / Q000209:etiology / Q000276:immunology*; D057705:Transendothelial and Transepithelial Migration; D015854:Up-Regulation
chemical_list: D018836:Inflammation Mediators; D020381:Interleukin-17
keywords: IL-17; inflammation; leukocyte adhesion deficiency; neutrophils; periodontitis