title: Liquid chromatographic enantiomer separation with special focus on zwitterionic chiral ion-exchangers.
abstract: This article provides a condensed introduction to principles of chiral separation, gives a historic overview of the genesis of the most important concepts regarding chiral stationary phase (CSPs), and summarizes the state of the art in a concise manner. Some recent developments in the field of polysaccharide CSPs are outlined. Finally, the article focusses on the new concept of zwitterionic chiral stationary phases and their application profile and peculiarities. Some other trends in column technology, including sub-2 μm and core-shell CSP particles and the emerging field of (UP)SFC, are briefly discussed.
authors.affiliation: Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany, michael.laemmerhofer@uni-tuebingen.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Lämmerhofer
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D007475:Ion Exchange Resins / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification*; D011134:Polysaccharides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D007475:Ion Exchange Resins; D010455:Peptides; D011134:Polysaccharides; D011506:Proteins