title: Novel treatment options in stage I non-small-cell lung cancer.
abstract: In the last 5 years, the current management of stage I non-small-cell lung cancer has been challenged due to novel surgical approaches and advances in radiation technology. The outcome after a sublobar resection is promising, especially for tumors less than 2 cm. Other treatment opportunities are available for high risk patients with comorbidity and impaired pulmonary function. Stereotactic ablative body radiotherapy is a good alternative treatment to surgery, especially in elderly and comorbid patients. However, randomized evidence comparing sublobar resection and stereotactic radiotherapy is presently lacking. The most recent development in radiotherapy is hadron therapy with a presumed reduced toxicity because of its peculiar physical and biological effects. Promising thermal and microwave ablative techniques are in development and have specific niche indications.
authors.affiliation: Department of Thoracic Oncology, Multidisciplinary Oncology Center Antwerp University Hospital, Antwerp, Belgium.
authors.forename: Svitlana
authors.initials: S
authors.lastname: Tarasevych
authors.forename: Patrick
authors.initials: P
authors.lastname: Lauwers
authors.forename: Frederik
authors.initials: F
authors.lastname: Vandaele
authors.forename: Jan P
authors.initials: JP
authors.lastname: van Meerbeeck
mesh_terms: D055011:Ablation Techniques; D000368:Aged; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008872:Microwaves / Q000627:therapeutic use; D009367:Neoplasm Staging; D016634:Radiosurgery / Q000379:methods*; D012307:Risk Factors
keywords: cryo-ablation; hadron therapy; image-guided ablation technique; microwave ablation; non-small-cell lung cancer; proton therapy; radiofrequency ablation; stereotactic body radiation therapy; sublobar resection