title: Autologous bone marrow stem cell transplantation for the treatment of postoperative hand infection with a skin defect in diabetes mellitus: A case report.
abstract: Among stem cells, autologous mesenchymal stem cells (MSCs) are ideal for transplantation by virtue of limited rejection reactions and marked proliferative ability. This study presents a novel method by which MSCs were harvested from the bone marrow of a patient who presented with severe post-traumatic infection and a non-healing skin defect in the hand, secondary to uncontrolled diabetes mellitus (DM). An autologous MSC suspension was injected into the persistent skin defect after stabilizing the blood glucose level and appropriate infection control. During the course of a regular 18-month postoperative follow-up, the patient exhibited immediate recovery with no transplant-associated complications, as well as no evidence of tumorigenicity. Thus, transplantation of autologous MSCs may play a role in the clinical application of stem cells, particularly for treatment of skin defects following surgery in cases of DM and for those caused by various other traumas.
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China ; Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Pujie
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Haoming
authors.initials: H
authors.lastname: Tian
authors.affiliation: Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Ai
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Guo
authors.affiliation: Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
authors.forename: Shenke
authors.initials: S
authors.lastname: Yang
keywords: autotransplantation; bone marrow mesenchymal stem cell; diabetes mellitus; skin defect; tumorigenicity