title: Comparative evaluation of cariogenic and erosive potential of commonly prescribed pediatric liquid medicaments: an in vitro study.
abstract: BACKGROUND
  Liquid oral medicines being the most accepted form of medication in children are frequently prescribed. The harmful effects of these liquid medicaments on a child's dental health are not known to many. The present study aimed to evaluate and compare the cariogenic and erosive potential of 5 most commonly prescribed pediatric liquid medicaments (PLM) in Pimpri Chinchwad and Pune city, Pune district.
  
  
  METHODS
  Most commonly prescribed PLM in Pune district were selected as opined by 50 pediatricians. The selected medicaments were Syr. Augmentin® Duo, Syr. Valparin®, Syr. Combiflam®, Syr. Visyneral and Syr. Orofer®. An estimation of pH, percentage of sucrose concentration and calcium dissolving capacity of these preparations was carried out. The results as obtained were subjected to statistical analysis using SPSS v 17.0 for windows. The statistical test as undertaken was Pearson's correlation coeffcient(r).
  
  
  RESULTS
  Sucrose was seen to be present in Syr. Combiflam® (35.75% ± 0.25%) and Syr. Visyneral (18.48% ± 0.43%). Acidic pH was observed for Syr. Visyneral (mean pH 3.63 ± 0.04), Syr. Combiflam®(mean pH 5.03 ± 0.02) and Syr. Augmentin® (mean pH 6.22 ± 0.02). Highest calcium dissolution was seen with Syr. Combiflam®(295.86 mg/ml) and the least with Syr. Orofer® (25.51 mg/ml). No statistical significant correlation was observed with calcium dissolution potential of PLM in comparison with their respective pH.
  
  
  CONCLUSIONS
  Syr. Combiflam® can be regarded as the highest cariogenic and erosive potential medicament among the compared and tested PLM.
  
  
  CONCLUSIONS
  Considering syrups with high cariogenic and erosive potential should always follow with proper oral hygiene practices or search for an alternative drugs void of such detrimental effects.
authors.affiliation: Postgraduate Student, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Nankar
authors.affiliation: Reader, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
authors.forename: Hrishikesh
authors.initials: H
authors.lastname: Walimbe
authors.affiliation: Lecturer, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
authors.forename: Mohammed Nadeem
authors.initials: MN
authors.lastname: Ahmed Bijle
authors.affiliation: Professor, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
authors.forename: Ujwal
authors.initials: U
authors.lastname: Kontham
authors.affiliation: Lecturer, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
authors.forename: Ananth
authors.initials: A
authors.lastname: Kamath
authors.affiliation: Postgraduate Student, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
authors.forename: Sneha
authors.initials: S
authors.lastname: Muchandi
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000032:analysis; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000032:analysis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000032:analysis; D000927:Anticonvulsants / Q000009:adverse effects / Q000032:analysis; D058633:Antipyretics / Q000009:adverse effects / Q000032:analysis; D002118:Calcium / Q000737:chemistry; D002326:Cariogenic Agents / Q000009:adverse effects*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects; D019587:Dietary Supplements / Q000009:adverse effects / Q000032:analysis; D004338:Drug Combinations; D005290:Ferric Compounds / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000009:adverse effects / Q000032:analysis; D019999:Pharmaceutical Solutions / Q000009:adverse effects* / Q000032:analysis; D012995:Solubility; D013395:Sucrose / Q000009:adverse effects / Q000032:analysis; D013549:Sweetening Agents / Q000009:adverse effects* / Q000032:analysis; D014077:Tooth Erosion / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects / Q000032:analysis; D014815:Vitamins / Q000009:adverse effects / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D058633:Antipyretics; D002326:Cariogenic Agents; D004338:Drug Combinations; D005290:Ferric Compounds; D019999:Pharmaceutical Solutions; D013549:Sweetening Agents; D014815:Vitamins; C021024:ferric hydroxide; D000082:Acetaminophen; D013395:Sucrose; D014635:Valproic Acid; D019980:Amoxicillin-Potassium Clavulanate Combination; D002118:Calcium; D007052:Ibuprofen