title: The angiotensin II type 2 receptor for pain control.
abstract: All well-known deleterious effects of angiotensin (Ang) II, including vasoconstriction, inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) receptor. This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease. Yet, Ang II has a second receptor, the Ang II type 2 (AT2) receptor, the function of which, even after over 20 years of research, remains largely unknown. In this issue, Marion et al. provide a new chapter to the AT2 receptor story.
authors.affiliation: Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam 3015 CN, The Netherlands. Electronic address: a.danser@erasmusmc.nl.
authors.forename: A H Jan
authors.initials: AH
authors.lastname: Danser
authors.affiliation: Centre for Clinical Translation, Division of Brain Sciences, Imperial College London, London W12 0NN, UK.
authors.forename: Praveen
authors.initials: P
authors.lastname: Anand
mesh_terms: D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D054312:Buruli Ulcer / Q000473:pathology*; D006801:Humans; D018942:Macrolides / Q000302:isolation & purification*; D019911:Mycobacterium ulcerans
chemical_list: D000809:Angiotensins; D018942:Macrolides; C117218:mycolactone