title: Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma.
abstract: BACKGROUND
  The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel that has been shown to promote tumor metastasis and progression. In this study, we determined the expression of TRPM7 in ovarian carcinomas and investigated its possible prognostic value.
  
  
  METHODS
  Samples were collected from 138 patients with ovarian cancer. Expression of TRPM7 was assessed by real-time PCR and immunohistochemistry, expressed with reference to an established scoring system and related to clinical pathological factors. Kaplan-Meier survival analysis was applied to estimate disease-free survival (DFS) and overall survival (OS). Univariate and multivariate cox regression analyses were performed to correlate TRPM7 expression levels with DFS and OS.
  
  
  RESULTS
  TRPM7 was highly expressed in ovarian carcinoma and significantly associated with decreased disease-free survival (DFS: median 20 months vs. 42 months, P=0.0002) and overall survival (OS: median 27 months vs. 46 months, P<0.001).
  
  
  CONCLUSIONS
  Overexpression of TRPM7 expression is significantly associated with poor prognosis in patients with ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynaecology, Xiangya Hospital, Central South University, Changsha, China E-mail : yizhang608@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.forename: Chen-Hui
authors.initials: CH
authors.lastname: Luo
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Tang
authors.forename: Kai-Ning
authors.initials: KN
authors.lastname: Fang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality* / Q000473:pathology*; D016016:Proportional Hazards Models; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D060888:Real-Time Polymerase Chain Reaction; D050053:TRPM Cation Channels / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D050053:TRPM Cation Channels; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human