title: The effect of experimental streptococcus infection in myocarditis on some biochemical and inflammatory markers in albino rats.
abstract: BACKGROUND
  Myocarditis is an uncommon disease that presents with a wide range of symptoms in children and adults. It is histologically characterized by varying degrees of myocardialnecrosis, edema and cellular infiltration myocardial inflammation is a nonspecificresponse to many triggers such as bacterial infection, cardio toxic agents, ormechanical injury.
  
  
  OBJECTIVE
  This study was carried out to investigate the experimental Streptococcus faecalis induction of myocarditis and its effect on some blood parameters, inflammatory markers and histopathological changes in male albino rats.
  
  
  METHODS
  Rats were infected by intraperitoneal injection of 10 8 CFU/ml of Streptococcus faecalis and sacrificed after one, two and seven days post infection. Biochemical analyses of blood were carried out to investigate the serum biomarkers of inflammation, liver function tests, cardiac enzymes & kidney function tests.
  
  
  RESULTS
  All biochemical analyses showed statistically significant increase in the measured parameters due to bacterial infections except for blood urea which appear to be normal. A significant positive correlation was observed between lactate dehydrogenase enzyme (LDH) with creatinine (r =0.778, P<0.01). In the 7 days group, there were significant positive correlations between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (r=0.675, P<0.05), erythrocyte sedimentation rate (ESR) with Urea (r=0.659, P<0.05) and alkaline phosphatase (ALP) with C-reactive protein (CRP) (r=0.765, p<0.01).
  
  
  CONCLUSIONS
  Many of these biomarkers will provide important new insights into pathophysiology and aid in the diagnosis and management of cardiovascular patients.
authors.affiliation: Department of Biochemistry, Faculty of Girls Science, King Abdulaziz University, Jeddah, Saudi Arabia ; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
authors.forename: S R
authors.initials: SR
authors.lastname: Kholoud
authors.affiliation: Department of hydrobiology, National Research Center, Cairo, Egypt.
authors.forename: M K A
authors.initials: MK
authors.lastname: Iman
authors.affiliation: Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
authors.forename: E H
authors.initials: EH
authors.lastname: Rasha
authors.affiliation: Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
authors.forename: S S A
authors.initials: SS
authors.lastname: Soha
mesh_terms: D000818:Animals; D015415:Biomarkers; D002097:C-Reactive Protein; D008111:Liver Function Tests; D008297:Male; D009205:Myocarditis / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D013290:Streptococcal Infections / Q000097:blood / Q000150:complications*; D013291:Streptococcus / Q000302:isolation & purification
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: C-reactive protein; Cardiovascular diseases; Myocarditis; Rat; Streptococcus faecalis