title: Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis.
abstract: OBJECTIVE
  To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis.
  
  
  METHODS
  In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were measured, and oral glucose tolerance test (OGTT) was performed. According to OGTT results two groups of patients were formed: those with normal glucose tolerance (NGT) and those with SAGT. Patients were followed every three months. The mean follow-up was 932 d (range of 180-1925). Survival was analyzed by the Kaplan-Meyer method, and predictive factors of death were analyzed using the Cox proportional hazard regression model.
  
  
  RESULTS
  Of the included patients, 30 showed NGT and 70 SAGT. Groups were significantly different only in age, INR, FPI and HOMA2-IR. Patients with SAGT showed lower 5-year cumulated survival than NGT patients (31.7% vs 71.6%, P = 0.02). Differences in survival were significant only after 3 years of follow-up. SAGT, Child-Pugh B, and high Child-Pugh and Model for End-Stage Liver Disease (MELD) scores were independent predictors of death. The causes of death in 90.3% of cases were due to complications related to liver disease.
  
  
  CONCLUSIONS
  SAGT was associated with lower survival. SAGT, Child-Pugh B, and high Child-Pugh and MELD scores were independent negative predictors of survival.
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: Diego
authors.initials: D
authors.lastname: García-Compeán
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: Joel Omar
authors.initials: JO
authors.lastname: Jáquez-Quintana
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: Fernando Javier
authors.initials: FJ
authors.lastname: Lavalle-González
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: José Alberto
authors.initials: JA
authors.lastname: González-González
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: Linda Elsa
authors.initials: LE
authors.lastname: Muñoz-Espinosa
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: Jesús Zacarías
authors.initials: JZ
authors.lastname: Villarreal-Pérez
authors.affiliation: Diego García-Compeán, Joel Omar Jáquez-Quintana, José Alberto González-González, Héctor J Maldonado-Garza, Gastroenterology Service and Department of Internal Medicine, University Hospital "Dr. José E. Gonzalez" and Medical School, Universidad Autónoma de Nuevo León, Monterrey 64320, México.
authors.forename: Héctor J
authors.initials: HJ
authors.lastname: Maldonado-Garza
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002423:Cause of Death; D016009:Chi-Square Distribution; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin
keywords: Diabetes mellitus; Glucose metabolism disorders; Liver cirrhosis; Oral glucose tolerance test; Survival