title: Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations.
abstract: Cutaneous melanoma is an aggressive malignant tumor of melanocytes which accounts for 80% of skin cancer-related deaths. A number of driver mutations have been identified in melanoma, with the mutually exclusive BRAF V600E and NRAS Q61A mutations together accounting for roughly 70% of mutations. Simultaneous BRAF V600E and NRAS Q61A mutations in melanoma are rare, with evidence suggesting that up to 2.9% (2/69) of primary cutaneous melanomas carry both mutations. Here we describe a 42-year-old man with concurrent BRAF E586K and NRAS Q81K driver mutations. To our knowledge, this is the first description of these driver mutations occurring simultaneously in primary cutaneous melanoma.
authors.affiliation: Department of PathologyClinical Pathology Molecular Pathology Consultative Services, La., USA.
authors.forename: Rodney
authors.initials: R
authors.lastname: Shackelford
authors.affiliation: Department of PathologyClinical Pathology Molecular Pathology Consultative Services, La., USA.
authors.forename: Maressa
authors.initials: M
authors.lastname: Pollen
authors.affiliation: Department of PathologyClinical Pathology Molecular Pathology Consultative Services, La., USA.
authors.forename: Moise
authors.initials: M
authors.lastname: Vora
authors.affiliation: Clinical Pathology Molecular Pathology Consultative Services, La., USA.
authors.forename: Tamara T
authors.initials: TT
authors.lastname: Jusion
authors.affiliation: Department of PathologyClinical Pathology Molecular Pathology Consultative Services, La., USA.
authors.forename: James
authors.initials: J
authors.lastname: Cotelingam
authors.affiliation: Hematology/Oncology, LSU Health Shreveport, Shreveport, La., USA.
authors.forename: Binu
authors.initials: B
authors.lastname: Nair
keywords: Concurrent BRAF E586K and NRAS Q81K mutations; Cutaneous melanoma; Skin cancer