title: Nanovalve activation by surface-attached photoacids.
abstract: Proton transfer caused by excitation of a photoacid attached to the surface of a mesoporous silica nanoparticle activates a nanovalve and causes release of trapped molecules. The protonation of an aniline-based stalk releases a noncovalently bound cyclodextrin molecule that blocked a pore. The results show that pH-responsive molecular delivery systems can be externally controlled using light.
authors.affiliation: Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095-1569, USA. zink@chem.ucla.edu.
authors.forename: T M
authors.initials: TM
authors.lastname: Guardado-Alvarez
authors.forename: M M
authors.initials: MM
authors.lastname: Russell
authors.forename: J I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D000143:Acids / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008027:Light; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D011721:Pyrenes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
chemical_list: C545559:6,8-dihydroxy-1,3-pyrenedisulfonic acid; D000143:Acids; D000814:Aniline Compounds; D003505:Cyclodextrins; D011721:Pyrenes; D013451:Sulfonic Acids; D012822:Silicon Dioxide; C023650:aniline