title: Long-term, naturalistic treatment with olanzapine, risperidone, quetiapine, or haloperidol monotherapy: 24-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study.
abstract: Objective. To compare the effectiveness of olanzapine, risperidone, quetiapine, or haloperidol monotherapy in patients with schizophrenia who were treated in routine clinical practice settings for a period of 2 years. The incidence and persistence of adverse events encountered during long-term therapy are also reported. Method. Outpatients with schizophrenia who entered this 3-year, prospective, observational study were classified according to their initially prescribed antipsychotic monotherapy: olanzapine (n=3222), risperidone (n=1116), quetiapine (n=189), or haloperidol (n=256). Patients were included in the analysis for as long as this treatment was maintained. Results. Over 2 years, olanzapine recipients had significantly (P≤0.001) greater reduction in overall CGI-S score (and the negative, depressive, and cognitive symptoms domains), lower incidence of sexual and motor dysfunction, and greater odds of response compared to risperidone or haloperidol-treated patients. However, olanzapine patients gained more weight than patients in other treatment groups. The incidence of motor dysfunction was significantly (P≤0.001) greater in haloperidol-treated patients, relative to the atypical treatment groups. Conclusion. The results of this observational study indicate that, in these patients with schizophrenia, long-term monotherapy with olanzapine may offer benefits over risperidone and haloperidol, but the potential for weight gain should be considered in the clinical management of these patients.
authors.affiliation: Neuroscience Division, Eli Lilly and Company, Taipei, Taiwan.
authors.forename: Phil
authors.initials: P
authors.lastname: Lee
authors.forename: Chul
authors.initials: C
authors.lastname: Eung Kim
authors.forename: Chang
authors.initials: C
authors.lastname: Yoon Kim
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Lin
authors.forename: Hussain
authors.initials: H
authors.lastname: Habil
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dyachkova
authors.forename: Margaret
authors.initials: M
authors.lastname: Mcbride
authors.forename: Martin
authors.initials: M
authors.lastname: Dossenbach
keywords: Antipsychotic agents; olanzapine; risperidone; schizophrenia; treatment outcome