title: Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs.
abstract: An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.
authors.affiliation: Division of Chemistry & Biological Chemistry, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
authors.forename: P-F
authors.initials: PF
authors.lastname: Koh
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: J-M
authors.initials: JM
authors.lastname: Huang
authors.forename: T-P
authors.initials: TP
authors.lastname: Loh
mesh_terms: D018533:Biomass; D018360:Crystallography, X-Ray; D005662:Furaldehyde / Q000737:chemistry; D008968:Molecular Conformation; D064729:Neurokinin-1 Receptor Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D010881:Piperidones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D010881:Piperidones; D005662:Furaldehyde