title: Hippocampus age-related microstructural changes in schizophrenia: a case-control mean diffusivity study.
abstract: Macrostructural-volumetric abnormalities of the hippocampus have been described in schizophrenia. Here, we characterized age-related changes of hippocampal mean diffusivity as an index of microstructural damage by carrying out a neuroimaging study in 85 patients with a DSM-IV-TR diagnosis of schizophrenia and 85 age- and gender-matched healthy controls. We performed analyses of covariance, with diagnosis as fixed factor, mean diffusivity as dependent variable and age as covariate. Patients showed an early increase in mean diffusivity in the right and left hippocampus that increased with age. Thus, microstructural hippocampal changes associated with schizophrenia cannot be confined to a specific time window.
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory, Via Ardeatina 306, 00179 Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Chiapponi
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory, Via Ardeatina 306, 00179 Rome, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Piras
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory, Via Ardeatina 306, 00179 Rome, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Fagioli
authors.affiliation: NESMOS Department, Sapienza University of Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory, Via Ardeatina 306, 00179 Rome, Italy; Department of Neuroscience, Tor Vergata University of Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory, Via Ardeatina 306, 00179 Rome, Italy. Electronic address: g.spalletta@hsantalucia.it.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Spalletta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult
keywords: Age; Hippocampus; Mean diffusivity; Schizophrenia; Trajectories