title: Changes in platelet functional parameters and CD62 P expression in liver cirrhosis.
abstract: BACKGROUND
  Hepatic impairment, portal hypertension, and multi-systemic damage could occur during liver cirrhosis's late stage. Bleeding is a complication of hepatic cirrhosis along with several changes including blood platelet count (BPC), mean platelet volume (MPV), platelet crit (PCT) and expression of platelet CD62P. Blood platelet count (BPC), mean platelet volume (MPV), platelet distribution width, and other indices are indirect reflections of CD62P parameters.
  
  
  OBJECTIVE
  To investigate the changes in platelet functional parameters and CD62 P expression in liver cirrhosis as a possible guide in clinical treatments and prognoses of liver cirrhosis.
  
  
  METHODS
  CD62P was tested by flow cytometry in liver cirrhosis. BPC, MPV, and PCT in peripheral blood were tested using an auto blood cell analyzer. Data were analyzed using SPSS11.0.
  
  
  RESULTS
  The values of CD62P and MPV in patients was significantly higher than those of healthy donors (P<0.01), while the values of BPC and PCT were significantly lower than those of the control group (P<0.01).
  
  
  CONCLUSIONS
  CD62P, BPC, MPV, and platelet crit (PCT) show several changes in liver cirrhosis. It is useful to understand the relationship between hepatic cirrhosis severity and CD62P, BPC, MPV, PCT, timely monitoring of CD62P for treatment of hepatic cirrhosis in clinical treatment and prognosis.
authors.affiliation: Center Department of Clinical Laboratory Medicine, Linyi People's Hospital, Linyi 276003, China.
authors.forename: G
authors.initials: G
authors.lastname: Xianghong
authors.affiliation: Center Department of Clinical Laboratory Medicine, Linyi People's Hospital, Linyi 276003, China.
authors.forename: C
authors.initials: C
authors.lastname: Guanping
authors.affiliation: Center Department of Clinical Laboratory Medicine, Linyi People's Hospital, Linyi 276003, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fenghua
authors.affiliation: Center Department of Clinical Laboratory Medicine, Linyi People's Hospital, Linyi 276003, China.
authors.forename: W
authors.initials: W
authors.lastname: Jiayin
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000503:physiopathology; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism*; D010976:Platelet Count; D012720:Severity of Illness Index
chemical_list: D019007:P-Selectin; C546937:SELP protein, human
keywords: Liver cirrhosis; expression; granula protein; platelet parameters