title: [Influence of tapentadol retard on functional parameters in patients with severe chronic pain--is there a benefit in daily life?].
abstract: BACKGROUND
  A patient-orientated therapy management for patients with severe chronic pain includes effective analgesia, improvement of health related quality of life and improvement of functionality.
  
  
  METHODS
  In this prospective, non-interventional trial in 630 patients with severe chronic pain mostly due to chronic low back pain or gonarthrosis, treatment with tapentadol retard was evaluated with respect to its effects on analgesia, functionality and quality of life. Collected data included pain intensity, painDETECT,SF-12, FFbH-R and FFbH-OA.
  
  
  RESULTS
  Mean pain intensity decreased significantly (NRS-3: -3.2 points, p < or = 0.001) and in 47.9% of the patients the mean pain intensity was reduced by at least 50%. Health-related quality of life and functionality improved significantly. Tolerability was good. The known tolerability profile of tapentadol retard could be confirmed.
  
  
  CONCLUSIONS
  In this study in real-life-setting tapentadol was effective in terms of analgesic effect but also in terms of improvementof health-related quality of life and functionality, leading to a benefit for the patient in daily life.
authors.forename: M
authors.initials: M
authors.lastname: Strohmeier
authors.forename: S
authors.initials: S
authors.lastname: Waldmann-Rex
authors.forename: K
authors.initials: K
authors.lastname: Schwenke
mesh_terms: D000203:Activities of Daily Living / Q000145:classification / Q000523:psychology; D000368:Aged; D001416:Back Pain / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000187:drug effects; D010636:Phenols / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011788:Quality of Life; D000077432:Tapentadol
chemical_list: D003692:Delayed-Action Preparations; D010636:Phenols; D000077432:Tapentadol