title: Common variants of xeroderma pigmentosum genes and prostate cancer risk.
abstract: The genetic basis of prostate cancer (PC) is complex and appears to involve multiple susceptibility genes. A number of studies have evaluated a possible correlation between several NER gene polymorphisms and PC risk, but most of them evaluated only single SNPs among XP genes and the results remain inconsistent. Out of 94 SNPs located in seven XP genes (XPA-XPG) a total of 15 SNPs were assayed in 720 unselected patients with PC and compared to 1121 healthy adults. An increased risk of disease was associated with the XPD SNP, rs1799793 (Asp312Asn) AG genotype (OR=2.60; p<0.001) and with the AA genotype (OR=531; p<0.0001) compared to the control population. Haplotype analysis of XPD revealed one protective haplotype and four associated with an increased disease risk, which showed that the A allele (XPD rs1799793) appeared to drive the main effect on promoting prostate cancer risk. Polymorphism in XPD gene appears to be associated with the risk of prostate cancer.
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland. Electronic address: debniak@pum.edu.pl.
authors.forename: Aneta
authors.initials: A
authors.lastname: Mirecka
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Paszkowska-Szczur
authors.affiliation: School of Biomedical Sciences, University of Newcastle, Australia.
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Thierry
authors.initials: T
authors.lastname: van de Wetering
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Wokołorczyk
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gromowski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Pablo
authors.initials: P
authors.lastname: Serrano-Fernandez
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Aniruddh
authors.initials: A
authors.lastname: Kashyap
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland; Postgraduate School of Molecular Medicine, Warsaw Medical University, Poland.
authors.forename: Satish
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Urology, Pomeranian Medical University, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Gołąb
authors.affiliation: Department of Urology, Pomeranian Medical University, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Słojewski
authors.affiliation: Department of Urology, Pomeranian Medical University, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sikorski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Dębniak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004268:DNA-Binding Proteins / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C497314:XPA protein, human; D051760:Xeroderma Pigmentosum Group A Protein; C095888:xeroderma pigmentosum group F protein; C086984:XPC protein, human; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human
keywords: Cancer; Polymorphism; Prostate; SNP; Xeroderma pigmentosum