title: Modulatory effect of nano TiO₂on Pb in Hoplias malabaricus trophically exposed.
abstract: This study investigated the hepatic and neural effects of TiO₂ nanoparticle and Pb in Hoplias malabaricus trophically exposed. The alanine transaminase activity was altered at the high dose of exposed group to Pb and at the lowest doses of co-exposed groups. It may reflect the hepatic effects of TiO₂ on Pb toxicity, but the aspatate transaminase activity was not altered. The decreased injury index observed at the highest dose of co-exposed group compared to TiO₂ may be related to the increased energy demand and can explain the more pronounced toxic effects observed in this group. The liver authomethallography revealed the metals presence at high dose groups. Serotonin concentration increased at the Pb lowest dose and at the highest dose of co-exposed group compare to control. Most importantly, when associated the contaminants were able to interact and altered some biomarkers. However, further studies, about action mechanisms of this co-exposure are needed.
authors.affiliation: Department of Pharmacology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil. Electronic address: ste_bio@yahoo.com.br.
authors.forename: Stéfani C
authors.initials: SC
authors.lastname: Rossi
authors.affiliation: Department of Cellular Biology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Maritana
authors.initials: M
authors.lastname: Mela
authors.affiliation: Department of Pharmacology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Suellen Lúcio
authors.initials: SL
authors.lastname: Boschen
authors.affiliation: Department of Pharmacology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Claudio
authors.initials: C
authors.lastname: da Cunha
authors.affiliation: Department of Cellular Biology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Francisco
authors.initials: F
authors.lastname: Filipak Neto
authors.affiliation: Department of Cellular Biology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Ciro A Oliveira
authors.initials: CA
authors.lastname: Ribeiro
authors.affiliation: Department of Pharmacology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Ana Paula Perbiche
authors.initials: AP
authors.lastname: Neves
authors.affiliation: Department of Pharmacology, Federal University of Paraná, PO Box 19031 81.531-980, Curitiba, Paraná, Brazil.
authors.forename: Helena C
authors.initials: HC
authors.lastname: Silva de Assis
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D060125:Characiformes; D007854:Lead / Q000493:pharmacokinetics / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D053758:Nanoparticles / Q000633:toxicity*; D012701:Serotonin / Q000378:metabolism; D014025:Titanium / Q000493:pharmacokinetics / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; C009495:titanium dioxide; D007854:Lead; D012701:Serotonin; D014025:Titanium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Autometallography; Biochemical biomarkers; Hoplias malabaricus; Inorganic lead; TiO(2) nanoparticles; Trophic exposure