title: Long-term follow-up of intermediate-risk non-muscle invasive bladder cancer sub-classified by multi-coloured FISH.
abstract: OBJECTIVE
  To examine the long-term follow-up of patients with that previously underwent risk stratification based on multicolour FISH testing.
  
  
  METHODS
  On 81 patients with intermediate-risk urothelial carcinoma, a multicolour-FISH was performed. Patients were sub-divided into low- and high-risk groups based on chromosomal patterns. Univariate analysis, using Mantel-Cox log-rank test for disease-free, progression-free survival and overall survival, was employed to determine the prognostic significance of FISH analysis. Survival times were calculated according to the Kaplan-Meier product-limit method and multivariate analysis using Cox proportional hazards regression model.
  
  
  RESULTS
  The univariate Mantel-Cox log-rank test showed significant differences between the low-risk and the high-risk group for disease-free survival (p=0.005) and overall survival (p=0.038), but not for progression-free survival (p=0.129).
  
  
  CONCLUSIONS
  Our long-term follow-up data appear to be able to divide tumors into low and high risk groups for recurrence based on molecular/genetic changes observed with FISH.
authors.affiliation: Department of Pathology, Central Hospital of Bolzano, Bolzano, Italy christine.mian@asbz.it.
authors.forename: Christine
authors.initials: C
authors.lastname: Mian
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Evi
authors.initials: E
authors.lastname: Comploj
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Resnyak
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Trenti
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Palermo
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Lodde
authors.affiliation: Riga Stradins University, Medical School, Riga, Latvia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pycha
authors.affiliation: Department of Pathology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ambrosini-Spaltro
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Dechet
authors.affiliation: Department of Urology, Central Hospital of Bolzano, Bolzano, Italy.
authors.forename: Armin
authors.initials: A
authors.lastname: Pycha
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*
keywords: Non muscle invasive bladder cancer; risk group; transurethral resection; urothelial cancer