title: Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development.
abstract: More than 98% of eukaryotic tanscriptomes are composed of non-coding RNAs with no functional protein-coding capacity. Those transcripts also include tens of thousands of long non-coding RNAs (lncRNAs) which are emerging as key elements of cellular homeostasis, essentially tumorigenesis steps. However, we are only beginning to understand the nature and extent of the involvement of lncRNAs on tumorigeneis. Here, we highlight recent progresses that have identified a myriad of molecular functions on tumorigenesis for several lncRNAs including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1), H19, and homeobox transcript antisense intergenic RNA (HOTAIR), and several new lncRNAs for glioma development. Potential therapeutic approaches for the lncRNAs in various human diseases are also discussed.
authors.affiliation: Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, Goyang, Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Park
authors.affiliation: Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, Goyang, Korea.
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Specific Organs Cancer Branch, Research Institute, National Cancer Center, Goyang, Korea. ; Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Jong Bae
authors.initials: JB
authors.lastname: Park
authors.affiliation: Specific Organs Cancer Branch, Research Institute, National Cancer Center, Goyang, Korea. ; Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Heon
authors.initials: H
authors.lastname: Yoo
authors.affiliation: Specific Organs Cancer Branch, Research Institute, National Cancer Center, Goyang, Korea. ; Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Seung-Hoon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, Goyang, Korea. ; Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Jong Heon
authors.initials: JH
authors.lastname: Kim
keywords: Glioma; Non-coding RNA; Tumorigenesis; lncRNA