title: Morbidity in early Parkinson's disease and prior to diagnosis.
abstract: BACKGROUND
  Nonmotor symptoms are probably present prior to, early on, and following, a diagnosis of Parkinson's disease. Nonmotor symptoms may hold important information about the progression of Parkinson's disease.
  
  
  OBJECTIVE
  To evaluated the total early and prediagnostic morbidities in the 3 years before a hospital contact leading to a diagnosis of Parkinson's disease.
  
  
  METHODS
  Retrospective morbidity data from Danish National Patient Registry records (1997-2007) of 10,490 adult patients with a secondary care diagnosis of Parkinson's disease were compared with 42,505 control cases.
  
  
  RESULTS
  Parkinson's disease was associated with significantly higher morbidity rates associated with conditions in the following categories: mental and psychiatric, nervous system, gastrointestinal, musculoskeletal system and connective tissue, genitourinary, abnormal clinical and laboratory findings, injury, poisoning and certain other external causes, and other factors influencing health status and contact with health services. It was negatively associated with neoplasm, cardiovascular, and respiratory diseases.
  
  
  CONCLUSIONS
  Patients with a diagnosis of Parkinson's disease present significant differences in morbidities early on, following, and prior to, their diagnosis, compared with healthy controls.
authors.affiliation: Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Glostrup Hospital Glostrup, Denmark.
authors.forename: Rune
authors.initials: R
authors.lastname: Frandsen
authors.affiliation: Danish Institute for Health Services Research Copenhagen, Denmark.
authors.forename: Jakob
authors.initials: J
authors.lastname: Kjellberg
authors.affiliation: itracks Klosterport 4E, Aarhus, Denmark.
authors.forename: Rikke
authors.initials: R
authors.lastname: Ibsen
authors.affiliation: Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Glostrup Hospital Glostrup, Denmark ; Faculty of Health Sciences, Center for Healthy Aging, University of Copenhagen Copenhagen, Denmark.
authors.forename: Poul
authors.initials: P
authors.lastname: Jennum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis*; D062706:Prodromal Symptoms; D011788:Quality of Life; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D063189:Symptom Assessment; D055815:Young Adult
keywords: Morbidities; National Patient Registry; Parkinson's disease; prediagnostic