title: Mixed valence copper(I,II) binuclear complexes with unexpected structure: synthesis, biological properties and anticancer activity.
abstract: We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.
authors.affiliation: Department of Chemistry, Lomonosov Moscow State University , Leninskie Gory, 1/3, 119991 Moscow, Russian Federation.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Majouga
authors.forename: Maria I
authors.initials: MI
authors.lastname: Zvereva
authors.forename: Maria P
authors.initials: MP
authors.lastname: Rubtsova
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Skvortsov
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Mironov
authors.forename: Dulat M
authors.initials: DM
authors.lastname: Azhibek
authors.forename: Olga O
authors.initials: OO
authors.lastname: Krasnovskaya
authors.forename: Vasily M
authors.initials: VM
authors.lastname: Gerasimov
authors.forename: Anna V
authors.initials: AV
authors.lastname: Udina
authors.forename: Nikolay I
authors.initials: NI
authors.lastname: Vorozhtsov
authors.forename: Elena K
authors.initials: EK
authors.lastname: Beloglazkina
authors.forename: Leonid
authors.initials: L
authors.lastname: Agron
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Mikhina
authors.forename: Alla V
authors.initials: AV
authors.lastname: Tretyakova
authors.forename: Nikolay V
authors.initials: NV
authors.lastname: Zyk
authors.forename: Nikolay S
authors.initials: NS
authors.lastname: Zefirov
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kabanov
authors.forename: Olga A
authors.initials: OA
authors.lastname: Dontsova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008810:Mice, Inbred C57BL; D008958:Models, Molecular; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D003300:Copper