title: A predictive model of the dynamics of body weight and food intake in rats submitted to caloric restrictions.
abstract: Dynamics of body weight and food intake can be studied by temporally perturbing food availability. This perturbation can be obtained by modifying the amount of available food over time while keeping the overall food quantity constant. To describe food intake dynamics, we developed a mathematical model that describes body weight, fat mass, fat-free mass, energy expenditure and food intake dynamics in rats. In addition, the model considers regulation of food intake by leptin, ghrelin and glucose. We tested our model on rats experiencing temporally variable food availability. Our model is able to predict body weight and food intake variations by taking into account energy expenditure dynamics based on a memory of the previous food intake. This model allowed us to estimate this memory lag to approximately 8 days. It also explains how important variations in food availability during periods longer than these 8 days can induce body weight gains.
authors.affiliation: Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan, Villeurbanne-Cedex, France; Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, Grenoble Rhône-Alpes, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Jacquier
authors.affiliation: Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan, Villeurbanne-Cedex, France; Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, Grenoble Rhône-Alpes, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Crauste
authors.affiliation: CarMeN, INSERM U1060, Université de Lyon, INSA-Lyon, Univ. Lyon-1, Villeurbanne, France.
authors.forename: Christophe O
authors.initials: CO
authors.lastname: Soulage
authors.affiliation: CarMeN, INSERM U1060, Université de Lyon, INSA-Lyon, Univ. Lyon-1, Villeurbanne, France; Project-Team Beagle, Inria Center Grenoble Rhône-Alpes, Grenoble Rhône-Alpes, France.
authors.forename: Hédi A
authors.initials: HA
authors.lastname: Soula
mesh_terms: D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D004435:Eating; D002149:Energy Intake; D004734:Energy Metabolism; D020738:Leptin / Q000378:metabolism; D008568:Memory / Q000502:physiology*; D008962:Models, Theoretical; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
chemical_list: D020738:Leptin