title: Interaction of Pd(2+) complexes of 2,6-disubstituted pyridines with nucleoside 5'-monophosphates.
abstract: To learn more about the underlying principles of metal-ion-mediated recognition of nucleic acid bases, PdCl(+) complexes of six 2,6-disubstituted pyridines, viz. pyridine-2,6-dicarboxamide, its N(2),N(6)-dimethyl and N(2),N(6)-diisopropyl derivatives, 6-carbamoylpyridine-2-carboxylic acid, 6-aminomethylpyridine-2-carboxamide and its N(2)-methyl derivative, were prepared and their interaction with nucleoside 5'-monophosphate (NMP) was studied by (1)H NMR spectroscopy in D2O at pH7.2. The binding sites within the nucleobases were assigned on the basis of Pd(2+) induced changes in chemical shifts of the base moiety proton resonances. The mole fractions of NMPs engaged in mono- or dinuclear Pd(2+) complexes were determined at various concentrations by comparing the intensities of the aromatic and anomeric protons of the complexed and uncomplexed NMPs. Some of the pyridine complexes showed moderate discrimination between the NMPs.
authors.affiliation: University of Turku, Department of Chemistry, FIN-20014 Turku, Finland.
authors.forename: Oleg
authors.initials: O
authors.lastname: Golubev
authors.affiliation: University of Turku, Department of Chemistry, FIN-20014 Turku, Finland.
authors.forename: Tuomas
authors.initials: T
authors.lastname: Lönnberg
authors.affiliation: University of Turku, Department of Chemistry, FIN-20014 Turku, Finland. Electronic address: harlon@utu.fi.
authors.forename: Harri
authors.initials: H
authors.lastname: Lönnberg
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009711:Nucleotides; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012265:Ribonucleotides / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D009711:Nucleotides; D011725:Pyridines; D012265:Ribonucleotides; C571561:pyridine-2,6-dicarboxamide; D010165:Palladium
keywords: 2,6-Disubstituted pyridines; NMR; Nucleotides; Pd(2+) complexes