title: Mitochondrial proteostasis in the control of aging and longevity.
abstract: Mitochondria play a central role in the aging process. Studies in model organisms have started to integrate mitochondrial effects on aging with the maintenance of protein homeostasis. These findings center on the mitochondrial unfolded protein response (UPR(mt)), which has been implicated in lifespan extension in worms, flies, and mice, suggesting a conserved role in the long-term maintenance of cellular homeostasis. Here, we review current knowledge of the UPR(mt) and discuss its integration with cellular pathways known to regulate lifespan. We highlight how insight into the UPR(mt) is revolutionizing our understanding of mitochondrial lifespan extension and of the aging process.
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.
authors.forename: Martin Borch
authors.initials: MB
authors.lastname: Jensen
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA. Electronic address: hjasper@buckinstitute.org.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Jasper
mesh_terms: D000375:Aging; D000818:Animals; D008136:Longevity; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D056811:Unfolded Protein Response
chemical_list: D014157:Transcription Factors; D011494:Protein Kinases; D058570:TOR Serine-Threonine Kinases; D010447:Peptide Hydrolases