title: Hypocaloric diet associated with the consumption of jam enriched with microencapsulated fish oil decreases insulin resistance.
abstract: BACKGROUND
  The metabolic syndrome is related to the increase in cardiovascular diseases. Polyunsaturated fatty acids from fish oil help in reducing cardiovascular risk factors and are natural bindings of PPAR2.
  
  
  OBJECTIVE
  To evaluate the impact of hypocaloric diet associated with microencapsulated fish oil supplementation in women with metabolic syndrome.
  
  
  METHODS
  We conducted a randomized, single-blind and placebo-controlled clinical trial with adult women who presented metabolic syndrome (n = 30) for 90 days. The volunteers were divided into two groups: placebo group (n = 15) and microencapsulated fish oil group (n = 15) (3 g/day of microencapsulated fish oil containing 0.41 g/day of eicosapentaenoic acid and decosahexaneoic acid). Anthropometric, body composition, clinical and laboratory parameters were assessed before and after the intervention. Paired t-test was used for comparisons within groups and Student's t-test for comparison between groups. We considered p < 0.05 as significant values.
  
  
  RESULTS
  The comparison between groups revealed a significant reduction of blood glucose, insulinemia and the homeostasis model assessment in the microencapsulated fish oil group after 90 days, as opposed to the placebo group. We also observed reduction of the systolic arterial pressure in the microencapsulated fish oil group.
  
  
  CONCLUSIONS
  A hypocaloric diet associated with the consumption of microencapsulated fish oil was effective in reducing blood glucose, insulinemia and insulin resistance in women with MS.
authors.affiliation: Master's degreee candidate of the Graduate Program in Medicine/Cardiology. Federal University of Rio de Janeiro. Medical School.. glorimar@nutricao.ufrj.br.
authors.forename: Anna Paula
authors.initials: AP
authors.lastname: Soares de Oliveira Carvalho
authors.affiliation: Doctor in Nutritional Sciences at the Graduate Program in Nutrition. Josué de Castro Institute of Nutrition. Federal University of Rio de Janeiro. Brazil..
authors.forename: Sofia
authors.initials: S
authors.lastname: Kimi Uehara
authors.affiliation: Professor of Department of Physiological Sciences. Biology Institute. State University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil..
authors.forename: José Firmino
authors.initials: JF
authors.lastname: Nogueria Netto
authors.affiliation: Associate Professor of Clinical Nutrition. Department of Nutrition and Dietetic. Josué de Castro Institute of Nutrition. Federal University of Rio de Janeiro. Brazil.. glorimar@nutricao.ufrj.br.
authors.forename: Glorimar
authors.initials: G
authors.lastname: Rosa
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004038:Diet, Reducing; D019587:Dietary Supplements; D004339:Drug Compounding; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006946:Hyperinsulinism / Q000178:diet therapy / Q000378:metabolism; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000188:drug therapy*; D008875:Middle Aged; D016037:Single-Blind Method
chemical_list: D001786:Blood Glucose; D005395:Fish Oils