title: Spontaneous pneumothorax associated with talc pulmonary granulomatosis after cocaine inhalation.
abstract: We report a case of recurrent spontaneous pneumothorax in a patient with cocaine abuse through inhalation alone. He underwent thoracoscopic apical lung resection with mechanical pleurodesis. Despite the lack of significant radiological features of talc induced pulmonary granulomatosis, pathological findings showed granulomas with foreign materials suggestive of being talc. Electronic microscopy showed that the size of talc particles were <4.0 µm and thus small enough to reach the alveoli.
authors.affiliation: Thoracic Surgery Unit, Second University of Naples, Piazza Miraglia, due, 80138, Naples, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Fiorelli
authors.affiliation: Department of Morphopathology, Second University of Naples, Naples, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Accardo
authors.affiliation: Laboratory of Applied Biotechnology, Department of Anesthesiology, Surgery, and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Thoracic Surgery Unit, Second University of Naples, Piazza Miraglia, due, 80138, Naples, Italy. mario.santini@unina2.it.
authors.forename: Mario
authors.initials: M
authors.lastname: Santini
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000150:complications* / Q000175:diagnosis; D005547:Foreign Bodies / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000175:diagnosis; D008297:Male; D011030:Pneumothorax / Q000175:diagnosis / Q000209:etiology*; D012008:Recurrence; D013627:Talc / Q000008:administration & dosage / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D013627:Talc; D003042:Cocaine
keywords: Cocaine; Granulomatosis; Lung; Pneumothorax; Talc