title: Multifunctional materials for bone cancer treatment.
abstract: The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.
authors.affiliation: Department of Materials and Ceramics Engineering, Centre for Research in Ceramics and Composite Materials, University of Aveiro, Aveiro, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Marques
authors.affiliation: Department of Materials and Ceramics Engineering, Centre for Research in Ceramics and Composite Materials, University of Aveiro, Aveiro, Portugal.
authors.forename: José M F
authors.initials: JM
authors.lastname: Ferreira
authors.affiliation: Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.affiliation: Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania.
authors.forename: Denisa
authors.initials: D
authors.lastname: Ficai
authors.affiliation: National Research and Development Institute for Textiles and Leather, Bucharest, Romania.
authors.forename: Maria
authors.initials: M
authors.lastname: Sonmez
authors.affiliation: Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania.
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D018786:Bone Substitutes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004867:Equipment Design; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D054457:Tissue Scaffolds
chemical_list: D000970:Antineoplastic Agents; D018786:Bone Substitutes; D053769:Nanocapsules
keywords: bone graft; cancer; collagen; cytostatics; magnetite; silver