title: [Protective effect of Shenxiong injection on cerebral ischemia-reperfusion injury of rats].
abstract: OBJECTIVE
  To study the protective effect of Shenxiong injection on the cerebral ischemia-reperfusion injury of senile rats.
  
  
  METHODS
  Totally 108 Sprague-Dawley (SD) rats were randomly divided into the sham operation group, the model group, the Ni-modipine group and Shenxiong injection groups (low, middle, and high doses). The rat brain ischemia-reperfusion model was established by the middle cerebral artery occlusion (MCAO) method in rats, in order to observe the effect of Shenxiong injection on neurological score and brain infarct volume of rats with cerebral ischemia-reperfusion injury, and determine the contents of NOS, NO, SOD, MDA and LDH in brain tissues. The contents of TNF-alpha and IL-1beta levels in brain tissues were measured by enzyme-linked immunosorbent assay (ELISA) method.
  
  
  RESULTS
  Shenxiong injection could significantly decrease neurological score, injury degree of brain tissues and brain infarct volume of rats with cerebral ischemia-reperfusion injury, increase the vigor of SOD, decrease the levels of MDA, NO, NOS and LDH, and inhibit IL-1beta and TNF-alpha expressions.
  
  
  CONCLUSIONS
  Shenxiong injection has the obvious protective effect on the brain ischemia-reperfusion injury in rats. Its mechanism may be related to the improvement of neurological function, the reduction of free radical injury, and the inhibition of inflammation factor expression.
authors.forename: Xing-Yu
authors.initials: XY
authors.lastname: Wang
authors.forename: Yu-Yan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Hai-Tong
authors.initials: HT
authors.lastname: Wan
authors.forename: Tao
authors.initials: T
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Fu
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Zhou
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Ze-Feng
authors.initials: ZF
authors.lastname: Wang
authors.forename: Jie-Hong
authors.initials: JH
authors.lastname: Yang
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D007267:Injections; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications* / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase