title: Efficacy and tolerability of quetiapine in cluster B personality disorder: an open-label study.
abstract: Objective. The aim of this open-label 8-week study was to assess the effectiveness of quetiapine on aggressive behaviour and social dysfunctions in patients suffering from a cluster B personality disorder (DSM-IV). Methods. The visits were performed at baseline and at days 14, 28 and 56. After a standard titration schedule, the patients received a dose augmented or reduced dose, within a range from 50 to 400 mg/day during the visits, depending on efficacy and tolerance. Assessment of efficacy was based on the French version of the Social Disability and Aggression Scale SDAS (SDAS-21). Response was defined as a decrease of ≥50% reduction of the total scores compared to baseline. Tolerability was assessed with the CGI, UKU, EPS-scales. Results and conclusion. Eight of the 12 patients included received 200 mg/day quetiapine after titration (all patients: 50-400 mg/day). At week 8, five out of 12 patients were responders based on the SDAS-21 scores for the average expression of the symptoms, and six out of 12 on the basis of SDAS-21 scores for the peak expression. There was a significant correlation between weight change and total SDAS variation (Kendall's τb= -0.644; p=0.02). These findings should be reexamined in further studies.
authors.affiliation: Département Universitaire de Psychiatrie Adulte et Service Universitaire de Psychiatrie de l'Âge Avancé, Site de Cery, Prilly-Lausanne, Switzerland.
authors.forename: Yves
authors.initials: Y
authors.lastname: Le Bloc'h
authors.forename: Pierre
authors.initials: P
authors.lastname: Baumann
authors.forename: Michael
authors.initials: M
authors.lastname: Stigler
authors.forename: Chin B
authors.initials: CB
authors.lastname: Eap
authors.forename: Daniele F
authors.initials: DF
authors.lastname: Zullino
authors.forename: Yves
authors.initials: Y
authors.lastname: Le Bloc'h
authors.forename: Pierre
authors.initials: P
authors.lastname: Baumann
authors.forename: Michael
authors.initials: M
authors.lastname: Stigler
authors.forename: Chin B
authors.initials: CB
authors.lastname: Eap
authors.forename: Daniele F
authors.initials: DF
authors.lastname: Zullino
keywords: Quetiapine; SDAS; cluster B personality disorder; plasma concentrations; weight