title: Reversible corpus callosum splenial lesion due to steroid therapy.
abstract: Reversible corpus callosum splenial (CCS) lesions are rare findings and usually detected incidentally. We presented a case of 15-year-old boy with a diagnoses of nephrotic syndrome. He was referred for neuropsychiatric symptoms following dose reduction on steroid treatment. Brain magnetic resonance imaging (MRI) revealed a focal lesion in the CCS, hyperintense on T2 and FLAIR and hypointense on T1 images with diffusion restriction on apparent diffusion coefficient map. Follow-up MRI 3 weeks later showed complete resolution of the lesion. It was probably result of focal intramyelinic edema due to excytotoxic mechanisms and/or arginine-vasopressin release.
authors.affiliation: Department of Radiology, School of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Aksu
authors.forename: Serpil
authors.initials: S
authors.lastname: Kurtcan
authors.forename: Alpay
authors.initials: A
authors.lastname: Alkan
authors.forename: Ayse
authors.initials: A
authors.lastname: Aralasmak
authors.forename: Faruk
authors.initials: F
authors.lastname: Oktem
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use*; D003337:Corpus Callosum / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D011605:Psychoses, Substance-Induced / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Corpus callosum splenial lesion; diffusion weighted imaging; steroid