title: Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract.
abstract: We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Yoon Hee
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Ida
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Shuya
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Tsukamoto
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Motofumi
authors.initials: M
authors.lastname: Kumazoe
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Sumida
authors.affiliation: Branch of Ishigaki, Okinawa Prefectural Agricultural Research Center, 1178-6 Hirae-Chisokobaru, Ishigaki, Okinawa 907-0003, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kawakami
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tachibana
keywords: Kakrol; Momordica dioica Roxb.; atopic dermatitis; histamine