title: Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis.
abstract: Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT), a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the central nervous system. In 2003 we have discovered the existence of a second Tph gene, which is expressed exclusively in the brain, and, therefore, is responsible for the 5-HT synthesis in the central nervous system. In the following years several research groups have independently generated Tph2-deficient mice. In this review we will summarize the data gained from the existing mouse models with constitutive or conditional deletion of the Tph2 gene, focusing on biochemical, developmental, and behavioral consequences of Tph2-deficiency.
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Valentina
authors.initials: V
authors.lastname: Mosienko
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Beis
authors.affiliation: Department of Biology, Unit of Cell and Developmental Biology, University of Pisa, Pisa, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Pasqualetti
authors.affiliation: Laboratory of Translational Neuroscience, Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany.
authors.forename: Jonas
authors.initials: J
authors.lastname: Waider
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Susann
authors.initials: S
authors.lastname: Matthes
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Fatimunnisa
authors.initials: F
authors.lastname: Qadri
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Bader
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany. Electronic address: alenina@mdc-berlin.de.
authors.forename: Natalia
authors.initials: N
authors.lastname: Alenina
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000172:deficiency* / Q000378:metabolism*; D014365:Tryptophan Hydroxylase / Q000235:genetics / Q000378:metabolism*
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; D014365:Tryptophan Hydroxylase
keywords: Animal model; Behavior; Serotonin; Serotonin receptors; Serotonin transporter; Tryptophan hydroxylase 2