title: Insulin-like growth factor 1 treatment of MSCs attenuates inflammation and cardiac dysfunction following MI.
abstract: It has been reported that insulin-like growth factor 1 (IGF-1) promoted migration of endothelial cells and cardiac resident progenitor cells. In the previous study, we found the time-dependent and dose-dependent effects of IGF-1 treatment on the CXCR4 expression in MSCs in vitro, but it is still not clear whether IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation role in myocardial infarction. In this study, we demonstrated that IGF-1-treated MSCs' transplantation attenuate cardiac dysfunction, increase the survival of engrafted cells in the ischemic heart, decrease myocardium cells apoptosis, and inhibit protein production and gene expression of inflammation cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6. IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation roles in post-myocardial infarction.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People's Republic of China, dr.guojun@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.forename: Dong
authors.initials: D
authors.lastname: Zheng
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Li
authors.forename: Hai-rui
authors.initials: HR
authors.lastname: Li
authors.forename: Ai-dong
authors.initials: AD
authors.lastname: Zhang
authors.forename: Zi-cheng
authors.initials: ZC
authors.lastname: Li
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007334:Insulin-Like Growth Factor I