title: Vascular Endothelial Growth Factor expression in peripheral blood of patients with pregnancy induced hypertension syndrome and its clinical significance.
abstract: OBJECTIVE
  This study was conducted was to detect vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) syndrome and to investigate VEGF correlation with PIH occurrence.
  
  
  METHODS
  Double-antibody enzyme-linked immunosorbent assay and fluorescent quantitative polymerase chain reaction were used to detect VEGF levels in the peripheral blood of non-pregnant women (normal group, 30 cases), normal pregnant women (pregnancy group, 30 cases) and PIH patients (PIH group, 30 cases).
  
  
  RESULTS
  VEGF level in the pregnancy group was significantly higher than in the normal group, and the difference between these two groups was significant (P < 0.001). In the pregnancy group, VEGF reached the maximum level at the metaphase stage of pregnancy and started to decrease at advanced pregnancy. VEGF level in the PIH group was significantly lower than in the pregnancy group at advanced pregnancy (P < 0.01), and VEGF level significantly and gradually decreased with PIH aggravation (P < 0.05).
  
  
  CONCLUSIONS
  The significant decrease of VEGF level after pregnancy was possibly an important factor of PIH pathogenesis.
authors.affiliation: Yanfang Ren, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Huiling Wang, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Wang
authors.affiliation: Haixia Qin, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Qin
authors.affiliation: Jun Yang, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Yuhong Wang, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shan Jiang, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Ying Pan, The Third First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
keywords: Cardiovascular; Hypertension; Pregnancy complications; Vascular endothelial growth factor