title: Medical treatment for pyometra in dogs.
abstract: Pyometra is a reproductive disorder very common in bitches over 8 years of age in which physiological effects of progesterone on the uterus play a major role. The traditional therapy for pyometra is ovariohysterectomy. The main advantage of ovariohysterectomy over medical management is that it is both curative and preventive for recurrence of pyometra. However, surgery is associated with the risk of anaesthesia and renders the bitch sterile. During the last 10 years, numerous medical treatments have been proposed to treat both open and closed cervix pyometra. The most effective medical treatment with minor side effects seems to be the repeated administration of aglepristone with or without the additional treatment with low doses of prostaglandins.
authors.affiliation: Department of Biotechnology and Pathology of Reproduction, Oniris, Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
authors.forename: F
authors.initials: F
authors.lastname: Fieni
authors.forename: E
authors.initials: E
authors.lastname: Topie
authors.forename: A
authors.initials: A
authors.lastname: Gogny
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004963:Estrenes / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D011453:Prostaglandins / Q000008:administration & dosage / Q000627:therapeutic use; D055112:Pyometra / Q000188:drug therapy / Q000662:veterinary*; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors*
chemical_list: D004963:Estrenes; D011453:Prostaglandins; D011980:Receptors, Progesterone; C419063:aglepristone