title: Immersive audiomotor game play enhances neural and perceptual salience of weak signals in noise.
abstract: All sensory systems face the fundamental challenge of encoding weak signals in noisy backgrounds. Although discrimination abilities can improve with practice, these benefits rarely generalize to untrained stimulus dimensions. Inspired by recent findings that action video game training can impart a broader spectrum of benefits than traditional perceptual learning paradigms, we trained adult humans and mice in an immersive audio game that challenged them to forage for hidden auditory targets in a 2D soundscape. Both species learned to modulate their angular search vectors and target approach velocities based on real-time changes in the level of a weak tone embedded in broadband noise. In humans, mastery of this tone in noise task generalized to an improved ability to comprehend spoken sentences in speech babble noise. Neural plasticity in the auditory cortex of trained mice supported improved decoding of low-intensity sounds at the training frequency and an enhanced resistance to interference from background masking noise. These findings highlight the potential to improve the neural and perceptual salience of degraded sensory stimuli through immersive computerized games.
authors.affiliation: Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114;Program in Speech Hearing Bioscience and Technology, Harvard-Massachusetts Institute of Technology Division of Health, Sciences, and Technology, Cambridge, MA 02139; and jpwhit05@mit.edu daniel_polley@meei.harvard.edu.
authors.forename: Jonathon P
authors.initials: JP
authors.lastname: Whitton
authors.affiliation: Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114;Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115.
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Hancock
authors.affiliation: Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114;Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115 jpwhit05@mit.edu daniel_polley@meei.harvard.edu.
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Polley
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009622:Noise; D010465:Perception / Q000502:physiology*; D018910:Video Games
keywords: cortical; foraging; gradient search; hearing; noise suppression