title: Langerhans cell sarcoma: case report and review of world literature.
abstract: Langerhans cell sarcoma is a rare malignancy with only 1 pediatric case (less than 15 y of age) reported. Here, we report the second case of Langerhans cell sarcoma in a child who presented with cord compression. This patient was treated with extensive surgical resection, postoperative chemotherapy, and involved-field radiation therapy. She completed therapy and remains in remission for 27 months. A review and analysis of all 53 cases published in the world literature is provided to help guide physicians treating this disease. Recently discovered genetic mutation involving BRAF is also discussed.
authors.affiliation: *Miller Children's Hospital, Long Beach †Department of Pediatrics, University of California, Irvine, CA ‡Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
authors.forename: Ted
authors.initials: T
authors.lastname: Zwerdling
authors.forename: Eric
authors.initials: E
authors.lastname: Won
authors.forename: Lisa
authors.initials: L
authors.lastname: Shane
authors.forename: Ramin
authors.initials: R
authors.lastname: Javahara
authors.forename: Ronald
authors.initials: R
authors.lastname: Jaffe
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D054752:Langerhans Cell Sarcoma / Q000235:genetics / Q000601:surgery / Q000628:therapy*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000601:surgery / Q000628:therapy*; D013125:Spinal Neoplasms / Q000235:genetics / Q000601:surgery / Q000628:therapy*; D013904:Thoracic Vertebrae / Q000473:pathology
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf