title: Rapid containment of coincident outbreaks with 2 carbapenem-resistant Klebsiella pneumoniae strains in an intensive care unit.
abstract: In our intensive care unit, coincident outbreaks were caused by concomitant cross-transmission of 2 carbapenem-resistant Klebsiella pneumoniae strains harboring distinct mechanisms of resistance. One strain produced extended-spectrum ß-lactamase in combination with reduced permeability. The other produced oxacillinase-48 carbapenemase. Rapid phenotypic detection of carbapenemase production allowed timely implementation of appropriate infection control measures.
authors.affiliation: Service Universitaire des Maladies Infectieuses et du voyageur, CH Tourcoing, Tourcoing, France. Electronic address: agnesmeybeck@yahoo.fr.
authors.forename: Agnès
authors.initials: A
authors.lastname: Meybeck
authors.affiliation: Equipe Opérationnelle d'Hygiène et d'Infectiologie, CH Roubaix.
authors.forename: Caroline
authors.initials: C
authors.lastname: Laurans
authors.affiliation: Service de Réanimation, Centre Hospitalier Roubaix, Roubaix, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Broucqsault-Dedrie
authors.affiliation: Service de Réanimation, Centre Hospitalier Roubaix, Roubaix, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Vanbaelinghem
authors.affiliation: Service de Réanimation, Centre Hospitalier Roubaix, Roubaix, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Verheyde
authors.affiliation: Equipe Opérationnelle d'Hygiène et d'Infectiologie, CH Roubaix.
authors.forename: Rita
authors.initials: R
authors.lastname: Ledez
authors.affiliation: Service de Réanimation, Centre Hospitalier Roubaix, Roubaix, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Nyunga
authors.affiliation: Equipe Opérationnelle d'Hygiène et d'Infectiologie, CH Roubaix.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Nottebaert
authors.affiliation: Equipe Opérationnelle d'Hygiène et d'Infectiologie, CH Roubaix.
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Waes
authors.affiliation: Equipe Opérationnelle d'Hygiène et d'Infectiologie, CH Roubaix; Laboratoire de Biologie, Centre Hospitalier Roubaix, Roubaix, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Vachée
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004196:Disease Outbreaks; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007362:Intensive Care Units; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems
keywords: Carbapenem; Klebsiella pneumoniae; Resistance