title: Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder.
abstract: The objective of this study was to determine periplakin expression in normal urothelium and bladder cancer tissues and the relationship to clinicopathological findings. Immunohistochemical staining for periplakin was carried out in 92 archival radical cystectomy specimens, with immunoreactivity being stratified on a 0-6 scale. Immunohistochemical staining for periplakin was shown to be significantly lower in bladder cancer tissues compared to non-cancerous tissues including inflammation,hyperplasia and normal urothelium. Loss of periplakin expression was associated with pathological stage (P=0.04). In multivariate Cox regression analysis, loss of periplakin expression and positive lymph node status were independent prognostic factors for cancer-specific survival (P=0.03 and 0.015; odds ratio=2.29 and 2.66; 95% confidence interval=1.085-4.814 and 1.214-5.845, respectively). This new molecular marker may aid in identifying and selecting bladder cancer patients undergoing radical cystectomy who may potentially benefit from neoadjuvant or adjuvant therapy.
authors.affiliation: Department of Urology, School of Medicine, Kitasato University, Kitasato 1-15-1, Minami-ku, Sagamihara-shi, Kanagawa 252-0374, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Masaomi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kuruma
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kamata
authors.forename: Takanori
authors.initials: T
authors.lastname: Nishimori
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tomonaga
authors.forename: Fumio
authors.initials: F
authors.lastname: Nomura
authors.forename: Shin
authors.initials: S
authors.lastname: Egawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Iwamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D051179:Plakins / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology* / Q000628:therapy
chemical_list: C491674:PPL protein, human; D051179:Plakins