title: A cross-sectional study of polycystic ovarian syndrome among adolescent and young girls in Mumbai, India.
abstract: BACKGROUND
  Polycystic ovary disease is a common endocrine condition which is rapidly gaining epidemic proportions. No community based prevalence data is available for this syndrome in India.
  
  
  METHODS
  A cross-sectional community-based study was undertaken in a sampled census block of Mumbai to assess the prevalence of polycystic ovarian syndrome (PCOS) among 778 adolescents and young girls aged 15-24 years. Among them, 600 completed all clinical, ultrasonography (USG), and biochemical investigations.
  
  
  RESULTS
  The prevalence of PCOS among them was 22.5% by Rotterdam and 10.7% by Androgen Excess Society criteria. Nonobese comprised 71.8% of PCOS diagnosed by Rotterdam criteria. Mild PCOS (oligomenorrhea and polycystic ovaries on USG) was the most common phenotype (52.6%). History of oligomenorrhea had a positive predictive value of 93.3% and negative predictive value of 86.7% to detect a possible case of PCOS. Hyperinsulinemia (serum insulin >15 μlU/mL) was present among 19.2% of diagnosed PCOS cases. Obese girls with PCOS were more hirsute, hypertensive, and had significantly higher mean insulin and 2 h post 75 g glucose levels compared with nonobese PCOS.
  
  
  CONCLUSIONS
  To our knowledge, this is the first urban community-based study diagnosing PCOS and phenotypes among adolescent and young girls in India. This study demonstrates that PCOS is an emerging disorder during adolescence and screening could provide opportunity to target the group for promoting healthy lifestyles and early interventions to prevent future morbidities.
authors.affiliation: Department of Operational Research, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India.
authors.forename: Beena
authors.initials: B
authors.lastname: Joshi
authors.affiliation: Department of Molecular Endocrinology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India.
authors.forename: Srabani
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Operational Research, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India.
authors.forename: Anushree
authors.initials: A
authors.lastname: Patil
authors.affiliation: Consultant, Cancer Patient AIDS Association, Mumbai, India.
authors.forename: Ameya
authors.initials: A
authors.lastname: Purandare
authors.affiliation: Department of Operational Research, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Chauhan
authors.affiliation: Director, Unit of Endocrine and Metabolic Disorders, Medical Research Center-Kasturba Health Society, Vile Parle, Mumbai, Maharashtra, India.
authors.forename: Rama
authors.initials: R
authors.lastname: Vaidya
keywords: Adolescents; India; phenotypes; polycystic ovarian syndrome; prevalencte