title: [Formula: see text]evidence of neuropsychological dysfunction in Stevens-Johnson Syndrome and toxic epidermal necrolysis: case report.
abstract: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) is a potentially life-threatening critical illness affecting multiple organ systems including the peripheral and central nervous system. This case report involves a young man who was diagnosed with SJS/TEN at age 16 and underwent neuropsychological assessment at age 21. Results indicate a diffuse pattern of cerebral compromise and represent a decline from premorbid level of functioning. The etiology of the cognitive impairment in this patient is likely multifactorial with possible pathophysiologic mechanisms including hypoxemia, metabolic acid-base perturbations, hyperglycemia, and delirium, as well as sepsis and inflammation.
authors.affiliation: a Los Angeles Neuropsychology Group , CA , USA.
authors.forename: George K
authors.initials: GK
authors.lastname: Henry
mesh_terms: D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D009483:Neuropsychological Tests; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000175:diagnosis*; D055815:Young Adult
keywords: Stevens–Johnson syndrome; Toxic epidermal necrolysis.