title: DNA copy number alterations in pleomorphic leiomyosarcoma: A case report.
abstract: Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12-13.1, 13q14.2-14.3, 15q25-26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (282M15/SP6) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data.
authors.affiliation: Department of Human Science, University of Toyama, Toyama City, Toyama 930-0194, Japan ; Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kanamori
authors.affiliation: Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Yasuda
authors.affiliation: Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Nogami
authors.affiliation: Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hori
keywords: DNA; chromosome; comparative genomic hybridization; leiomyosarcoma