title: Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
abstract: Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
authors.affiliation: Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany.
authors.forename: Julie
authors.initials: J
authors.lastname: Lucifora
authors.affiliation: Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Reisinger
authors.affiliation: Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Heikenwalder
authors.affiliation: Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany. protzer@tum.de protzer@helmholtz-muenchen.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Protzer
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004270:DNA, Circular / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism*; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D053259:Lymphotoxin beta Receptor / Q000819:agonists*
chemical_list: D000998:Antiviral Agents; D004270:DNA, Circular; D004279:DNA, Viral; D016898:Interferon-alpha; D053259:Lymphotoxin beta Receptor