title: Gremlins sabotage the mechanisms of cancer stem cell differentiation.
abstract: BMP is highly expressed in glioblastoma and promotes differentiation of cancer stem cells (CSCs). Recently, Yan and colleagues found the explanation to this apparent paradox by showing that the antagonist of BMP, Gremlin1, is secreted by CSCs to protect them against the BMP-induced differentiation.
authors.affiliation: Vall d Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain; Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain. Electronic address: jseoane@vhio.net.
authors.forename: Joan
authors.initials: J
authors.lastname: Seoane
mesh_terms: D000818:Animals; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins