title: Whole genome sequence of a goose haemorrhagic polyomavirus detected in Hungary.
abstract: Goose haemorrhagic polyomavirus (GHPV) provoke haemorrhagic nephritis and enteritis of domestic geese. Outbreaks were detected in European countries and caused economic losses for goose keepers. Domestic ducks may be infected with GHPV without any signs typical for geese. The genomic organisation of some isolates was described but the gene functions and the pathomechanisms of the virus was not precisely defined. Here we describe the genome sequence and structure of GHPV of a goose from a Hungarian goose flock showing characteristics of the haemorrhagic nephritis and enteritis. The GHPV genome investigated in this study was 5252 bp long and was very similar (99% nucleotide identity) to sequences deposited in the GenBank. All the whole GHPV genomes possess the same ORFs in length, including the VP1, VP2, VP3, ORF-X, t and T tumour antigens. Amino acid changes are detected mainly in the putative ORF-X region. Data about the GHPV genome imply a conserved genomic structure among isolates from different countries. Genomic and epidemiological studies may help vaccine development efforts and identify potential heterologous reservoirs of GHPV.
authors.affiliation: Hungarian Academy of Sciences Institute for Veterinary Medical Research, Centre for Agricultural Research Budapest Hungary.
authors.forename: Enikő
authors.initials: E
authors.lastname: Fehér
authors.affiliation: Hungarian Defence Forces Military Medical Centre Budapest Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Lengyel
authors.affiliation: National Food Chain Safety Office Veterinary Diagnostic Directorate Budapest Hungary.
authors.forename: Adám
authors.initials: A
authors.lastname: Dán
authors.affiliation: Hungarian Academy of Sciences Institute for Veterinary Medical Research, Centre for Agricultural Research Budapest Hungary.
authors.forename: Szilvia L
authors.initials: SL
authors.lastname: Farkas
authors.affiliation: Hungarian Academy of Sciences Institute for Veterinary Medical Research, Centre for Agricultural Research Budapest Hungary.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bányai
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D030561:Databases, Nucleic Acid; D005777:Geese / Q000821:virology*; D016679:Genome, Viral; D006814:Hungary / Q000453:epidemiology; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011120:Polyomavirus / Q000235:genetics*; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology*; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D014764:Viral Proteins
keywords: duck; goose; haemorrhagic nephritis and enteritis; polyomaviruses; vaccine development