title: The MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes.
abstract: BACKGROUND
  Polymorphism of rs2293855 in gene MTMR9 has been associated with obesity and metabolic syndrome. We aim to study the association of rs2293855 with type 2 diabetes mellitus (T2DM) intermediate phenotypes in a Han Chinese population.
  
  
  METHODS
  The polymorphism was genotyped in 838 Han Chinese individuals using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS); all participants underwent a 75 g oral glucose tolerance test (OGTT); associations between the polymorphism and glucose tolerance, indices of insulin secretion and indices of insulin sensitivity were analyzed.
  
  
  RESULTS
  The frequency of genotypes and alleles differed significantly between normal glucose tolerance and prediabetes (P=0.043 and P=0.009, respectively). The GG homozygous presented higher fasting plasma glucose (P=0.009), higher 2-hour plasma glucose (P=0.024) and higher glucose area under the curve (AUC, P=0.01). Moreover, the G allele of rs2293855 was associated with glucose intolerance (fasting glucose, P=0.012; glucose AUC, P=0.006; 2-h glucose, P=0.024); it is also associated with decreased indices of insulin sensitivity (fasting insulin, P=0.043; insulin sensitivity index composite, P=0.009; homeostasis model assessment of insulin resistance, HOMA-IR, P=0.008) and decreased indices of insulin secretion (HOMA of beta cell function, HOMA-B, P=0.028; insulinogenic index, P=0.003). In addition, the minor allele G was also associated with increased risk of prediabetes (OR=1.463, 95%CI: 1.066-2.009, P=0.018).
  
  
  CONCLUSIONS
  Polymorphism of rs2293855 in MTMR9 is associated with measures of glucose tolerance, indices of insulin secretion and indices of insulin sensitivity. We also suggest that allele G is likely to increase the risk of prediabetes by influencing both insulin secretion and insulin sensitivity.
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Clinical Medicine, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Division of Endocrinology and Metabolism, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.
authors.forename: H
authors.initials: H
authors.lastname: Cao
authors.affiliation: Chengdu Aerospace Hospital, Chengdu, Sichuan, China.
authors.forename: S
authors.initials: S
authors.lastname: Xie
authors.affiliation: Division of Endocrinology and Metabolism, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Lü
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Chengdu Yincao Community Hospital, Chengdu, Sichuan, China.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.affiliation: Chengdu Aerospace Hospital, Chengdu, Sichuan, China.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.affiliation: Chengdu Aerospace Hospital, Chengdu, Sichuan, China.
authors.forename: C
authors.initials: C
authors.lastname: Yu
authors.affiliation: Chengdu Aerospace Hospital, Chengdu, Sichuan, China.
authors.forename: W
authors.initials: W
authors.lastname: Jin
authors.affiliation: Chengdu Aerospace Hospital, Chengdu, Sichuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address: michaelnwtong@hotmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Tong
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D002681:China; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005947:Glucose; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000235:genetics*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D007328:Insulin; C435691:MTMR9 protein, human; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D005947:Glucose
keywords: Genetic; MTMR9; OGTT; Prediabetes; rs2293855