title: Effect of Lacto-N-biose I on the Antigen-specific Immune Responses of Splenocytes.
abstract: We examined the effect of lacto-N-biose I (LNB) on Antigen (Ag)-specific responses of immune cells. LNB exposure in vitro suppressed Ag-specific Interleukin (IL)-4 secretion of mouse splenocytes significantly. However, IL-4 secretion from CD4(+) T cells stimulated with anti-CD3ε did not changed significantly with LNB exposure. Additionally, Ag-specific Th1 cytokines did not change. Therefore LNB might suppress Ag-specific IL-4 through modification of Ag-presenting cells (APCs) in a manner independent of Th1-type immune development.
authors.affiliation: National Agriculture and Food Research Organization National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Goto
authors.affiliation: National Agriculture and Food Research Organization National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takano-Ishikawa
authors.affiliation: National Agriculture and Food Research Organization National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Nishimoto
authors.affiliation: National Agriculture and Food Research Organization National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
authors.forename: Motomitsu
authors.initials: M
authors.lastname: Kitaoka
keywords: IL-4; LNB; anti-allergy; naïve immune cells