title: 18F-FLT PET/CT imaging in a Wister rabbit inflammation model.
abstract: The aim of the present study was to determine the tumour specificity of the newly developed nucleoside metabolic positron emission tomography (PET) tracer, 3'-deoxy-3'-18F-fluorothymidine (18F-FLT). Using18F-FLT PET imaging, DNA synthesis and cell proliferation were detected inStaphylococcus aureus (S. aureus)abscess and calcium sulphate models in Wister rabbits. A total of eight rabbits were implanted withS. aureusin the left tibia to induce an inflammatory process. Calcium sulphate + gentamicin was implanted in the right tibia to induce a physical stimulus without bacterial multiplication. After four weeks, the animals underwent18F-FLT PET imaging, bacterial culturing and tissue pathology. The uptake of18F-FLT was significantly higher in the abscess site compared with that in the granuloma, with maximum standardised uptake values of 5.76±0.25 and 1.15±0.32, respectively (P<0.01). This indicates that18F-FLT is not a specific tumour tracer since active inflammation also results in the uptake of this compound. However, the tumour specificity of this tracer is higher compared with that of18F-fluorodeoxyglucose. Therefore,18F-FLT may be useful in the differential diagnosis of benign and malignant tumours.
authors.affiliation: PET-CT Center, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Yeying
authors.initials: Y
authors.lastname: Tan
authors.affiliation: PET-CT Center, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: PET-CT Center, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Defeng
authors.initials: D
authors.lastname: Liu
authors.affiliation: PET-CT Center, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.affiliation: PET-CT Center, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Guanmin
authors.initials: G
authors.lastname: Wang
authors.affiliation: PET-CT Center, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Urology, The Affiliated School of Clinical Medicine of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Conghui
authors.initials: C
authors.lastname: Han
keywords: 3′-deoxy-3′-18F-fluorothymidine; Staphylococcus aureus model; gentamicin + calcium sulphate model