title: Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis.
abstract: BACKGROUND
  Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness (CIMT) in patients with non-functioning AI (NFAI).
  
  
  METHODS
  This study included data from 28 patients with NFAI (Group 1) and 41 controls (Group 2). Of the patients, 50 were female and 19 were male, and the mean age was 46.7 (range 37-65) years.
  
  
  RESULTS
  There were no significant differences between Group 1 and 2 in terms of age, sex, or BMI. Hypertension prevalence was significantly higher in the NFAI group than in the control group (p = 0.01). Both groups had similar lipid, blood glucose, homocysteine, uric acid, high-sensitivity CRP levels. Adiponectin, leptin, and resistin levels were similar in both groups. CIMTs were significantly higher in the NFAI group.
  
  
  CONCLUSIONS
  There is increasing evidence that several cardiometabolic risk factors occur with higher prevalence in non-functioning adrenal incidentaloma patients compared to age-matched healthy subjects. In our study, hypertension prevalence and CIMT were higher in the NFAI group. Serum adipokine levels were similar for both groups.
authors.affiliation: Endocrinology and Metabolism Division, Medical Faculty, Dicle University, Diyarbakır, Turkey. tunamazhar@gmail.com.
authors.forename: Mazhar Müslüm
authors.initials: MM
authors.lastname: Tuna
authors.affiliation: Endocrinology and Metabolism Division, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Narin Nasıroğlu
authors.initials: NN
authors.lastname: Imga
authors.affiliation: Endocrinology and Metabolism Division, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Berçem Ayçiçek
authors.initials: BA
authors.lastname: Doğan
authors.affiliation: Biochemistry Division, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatma Meriç
authors.initials: FM
authors.lastname: Yılmaz
authors.affiliation: Biochemistry Division, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topçuoğlu
authors.affiliation: Endocrinology and Metabolism Division, Medical Faculty, Mugla University, Muğla, Turkey.
authors.forename: Gülhan
authors.initials: G
authors.lastname: Akbaba
authors.affiliation: Endocrinology and Metabolism Division, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.affiliation: Endocrinology and Metabolism Division, Medical Faculty, Hitit University, Çorum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Güler
mesh_terms: D054392:Adipokines / Q000097:blood; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology*; D002097:C-Reactive Protein / Q000032:analysis; D059168:Carotid Intima-Media Thickness; D005260:Female; D006710:Homocysteine / Q000097:blood; D006784:Hospitals, Teaching; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D054392:Adipokines; D006710:Homocysteine; D002097:C-Reactive Protein