title: Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives.
abstract: Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4-0.5 μM are able to show in vivo activity.
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Chaparro
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Vidal
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Iñigo
authors.initials: I
authors.lastname: Angulo-Barturen
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Bueno
authors.affiliation: Medicines for Malaria Venture (MMV) , 20 route de Pré-Bois, 1215 Geneva 15, Switzerland.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Burrows
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Cammack
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Castañeda
authors.affiliation: Centro de Investigación Básica, GlaxoSmithKline , Santiago Grisolía, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Colmenarejo
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Coterón
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: de Las Heras
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Fernández
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Ferrer
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Gabarró
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Gamo
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: García
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: María B
authors.initials: MB
authors.lastname: Jiménez-Díaz
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Lafuente
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: María L
authors.initials: ML
authors.lastname: León
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: María S
authors.initials: MS
authors.lastname: Martínez
authors.affiliation: GlaxoSmithKline , 5 Moore Drive, Research Triangle Park, Durham, North Carolina 27709, United States.
authors.forename: Douglas
authors.initials: D
authors.lastname: Minick
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Prats
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Puente
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Rueda
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Sandoval
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Santos-Villarejo
authors.affiliation: Medicines for Malaria Venture (MMV) , 20 route de Pré-Bois, 1215 Geneva 15, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Witty
authors.affiliation: Tres Cantos, Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Calderón
keywords: Aminoalcoholes; TCAMS; malaria; mefloquine; tres cantos antimalarial set