title: Antitumor and wound healing properties of Rubus niveus Thunb. root.
abstract: The main objective of this study is to highlight the importance of Rubus niveus in the pharmaceutical industry for the development of cost-effective drugs. The study was undertaken to explore the HPLC profile, wound healing, antitumor, and free radical scavenging properties of R. niveus. The root of R. niveus was extracted using organic solvents and subjected to in vitro antioxidant assays. Acetone extract, which showed better in vitro antioxidant properties, was evaluated for in vivo antioxidant, wound healing, and antitumor properties. The polyphenolic acetone extract showed significant in vivo antioxidant, wound healing, and antitumor properties. In the wound healing study, complete epithelialization was noticed during the 13th to 17th days for treated groups. The 250 mg/kg group was found to prolong the life span of mice with Ehrlich ascites carcinoma (70.04%) and reduced the volume of Daltons lymphoma ascites solid tumors (2.07 cm3). The HPLC analysis of acetone extract revealed the presence of Quercetin, a natural flavonoid with the retention time of 20.89 min. The results of the current study suggest the use of R. niveus as a valuable natural antioxidant that has an immense scope as an effective source to cure skin diseases, wounds, and tumors.
authors.affiliation: Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.
authors.forename: Blassan Plackal
authors.initials: BP
authors.lastname: George
authors.affiliation: Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.
authors.forename: Thangaraj
authors.initials: T
authors.lastname: Parimelazhagan
authors.affiliation: Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.
authors.forename: Thankarajan
authors.initials: T
authors.lastname: Sajeesh
authors.affiliation: Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Saravanan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D027824:Rosaceae / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts