title: Clinical analysis of 102 cases of Epstein-Barr virus infections in Chinese children.
abstract: The purpose of this study is to investigate the clinical manifestations and disease severity, to evaluate the recent trend of clinical manifestations and differences in the clinical and laboratory findings of EBV-associated IM (infectious mononucleosis) according to the age of children. We retrospectively collected cases on hospitalized patients a majority of 7 years old with characteristic symptoms of IM and serologically diagnosed EBV-associated IM at Shaanxi Provincial Peoples University Hospital in Xi'an from Apr, 2012 to Oct, 2013. All their medical records were reviewed and analyzed. For each patient, clinical, laboratory data and outcome were collected retrospectively and compared to previous studies to evaluate the differences between the clinical and laboratory findings of patients of different ages. The clinical manifestations in children with EB virus infection varied. There were 60 (58.8%) cases of children with infectious mononucleosis, 26 (25.49%) cases of Epstein-barr virus infection,16 cases of the atypical EB virus infection, accounting for 15.67%. 78% children were under 7 years of age, 12% were 7 to 14 years of age. There are differences in the symptoms and signs among the different age groups. The clinical manifestations in children with EB virus infection involved multiple systems and produced harm is heavier and should be paid attention to during the treatment. The disease continues to occur mostly in children under 10 years of age. When compared to previous Chinese studies about 15 years ago, the age distribution was similar and the incidence of hepatosplenomegaly was lower in our study.
authors.affiliation: Department of Pediatrics, Shaanxi Provincial Peoples Hospital of Xian Jiaotong University, Xi'an, China; Class of 2011 of Postgraduate of Dept of Kunnming Medical University, PRC.
authors.forename: Fuyong
authors.initials: F
authors.lastname: Jiao
authors.affiliation: Department of Pediatrics, Shaanxi Provincial Peoples Hospital of Xian Jiaotong University, Xi'an, China; Class of 2011 of Postgraduate of Dept of Kunnming Medical University, PRC.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Pediatrics, Shaanxi Provincial Peoples Hospital of Xian Jiaotong University, Xi'an, China; Class of 2011 of Postgraduate of Dept of Kunnming Medical University, PRC.
authors.forename: Xianpeng
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Pediatrics, Shaanxi Provincial Peoples Hospital of Xian Jiaotong University, Xi'an, China; Class of 2011 of Postgraduate of Dept of Kunnming Medical University, PRC.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Shaanxi Provincial Peoples Hospital of Xian Jiaotong University, Xi'an, China; Class of 2011 of Postgraduate of Dept of Kunnming Medical University, PRC.
authors.forename: Kevin
authors.initials: K
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000473:pathology* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D007244:Infectious Mononucleosis / Q000097:blood / Q000473:pathology* / Q000821:virology; D008297:Male; D012189:Retrospective Studies