title: Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.
abstract: Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: de Mello Schier
authors.forename: Natalia P
authors.initials: NP
authors.lastname: de Oliveira Ribeiro
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Coutinho
authors.forename: Sergio
authors.initials: S
authors.lastname: Machado
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
authors.forename: Jose A
authors.initials: JA
authors.lastname: Crippa
authors.forename: Antonio W
authors.initials: AW
authors.lastname: Zuardi
authors.forename: Antonio E
authors.initials: AE
authors.lastname: Nardi
authors.affiliation: Institute of Psychiatry - Federal University of Rio de Janeiro. Laboratory of Panic and Respiration. Rua Visconde de Piraja, 407/702, Rio de Janeiro, RJ. CEP 22410-003, Brazil. alexschier@hotmail.com.
authors.forename: Adriana C
authors.initials: AC
authors.lastname: Silva
mesh_terms: D001007:Anxiety / Q000188:drug therapy*; D002186:Cannabinoids / Q000737:chemistry / Q000627:therapeutic use*; D002188:Cannabis / Q000737:chemistry; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D064086:Medical Marijuana / Q000627:therapeutic use*
chemical_list: D002186:Cannabinoids; D064086:Medical Marijuana