title: IL-17 promotes murine lupus.
abstract: The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17-deficient mice was associated with a reduced frequency of CD3(+)CD4(-)CD8(-) double-negative T cells and an expansion of CD4(+) regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE.
authors.affiliation: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; and.
authors.forename: Gil
authors.initials: G
authors.lastname: Amarilyo
authors.affiliation: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; and.
authors.forename: Elaine V
authors.initials: EV
authors.lastname: Lourenço
authors.affiliation: Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013.
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
authors.affiliation: Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; and alacava@mednet.ucla.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: La Cava
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D020381:Interleukin-17 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000235:genetics / Q000276:immunology*; D008181:Lupus Nephritis / Q000097:blood / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D013729:Terpenes; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D020381:Interleukin-17; D013729:Terpenes; C009042:pristane