title: Literature review of clinical results of total skin electron irradiation (TSEBT) of mycosis fungoides in adults.
abstract: BACKGROUND
  Mycosis fungoides (MF) is an extranodal, indolent non-Hodgkin lymphoma of T cell origin. Even with the establishment of MF staging, the initial treatment strategy often remains unclear.
  
  
  OBJECTIVE
  The aim of this study was to review the clinical results of total skin electron beam therapy (TSEBT) for MF in adults published in English language scientific journals searched in Pubmed/Medline database until December 2012.
  
  
  RESULTS
  MF is very sensitive to radiation therapy (RT) delivered either by photons or by electrons. In limited patches and/or plaques local electron beam irradiation results in good outcomes besides the fact of not being superior to other modalities. For extensive patches and/or plaques data suggest that TSEBT shows superior response rates. The cutaneous disease presentation is favorably managed with radiotherapy due to its ability to treat the full thickness of deeply infiltrated skin. For generalized erythroderma presentation, TSEBT seems to be an appropriate initial therapy. For advanced disease, palliation, or recurrence after the first radiotherapy treatment course, TSEBT may still be beneficial, with acceptable toxicity. Recommended dose is 30-36 Gy delivered in 6-10 weeks.
  
  
  CONCLUSIONS
  TSEBT can be used to treat any stage of MF. It also presents good tumor response with symptoms of relief and a palliative effect on MF, either after previous irradiation or failure of other treatment strategies.
authors.affiliation: Department of Radiation Oncology, Hospital Sírio-Libânes, São Paulo, SP, Brazil.
authors.forename: Fabio Ynoe de
authors.initials: FY
authors.lastname: Moraes
authors.affiliation: Department of Radiation Oncology, Hospital Sírio-Libânes, São Paulo, SP, Brazil ; Radiotherapy - Department of Radiology and Oncology, Radiology Institute - InRad, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Heloisa de Andrade
authors.initials: Hde A
authors.lastname: Carvalho
authors.affiliation: Department of Radiation Oncology, Hospital Sírio-Libânes, São Paulo, SP, Brazil.
authors.forename: Samir Abdallah
authors.initials: SA
authors.lastname: Hanna
authors.affiliation: Department of Radiation Oncology, Hospital Sírio-Libânes, São Paulo, SP, Brazil.
authors.forename: João Luis Fernandes da
authors.initials: JL
authors.lastname: Silva
authors.affiliation: Department of Radiation Oncology, Hospital Sírio-Libânes, São Paulo, SP, Brazil ; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo - ICESP, São Paulo, SP, Brazil.
authors.forename: Gustavo Nader
authors.initials: GN
authors.lastname: Marta
keywords: Electron beam therapy; Mycosis fungoides; Radiotherapy; Total skin irradiation