title: Protective effects of chelerythrine against lipopolysaccharide-induced endotoxic shock in mice.
abstract: Chelerythrine (CHE), a quaternary benzo[c]phenanthridine alkaloid, exhibits a wide spectrum of pharmacological effects. Although CHE has been used to treat various diseases, the protective effects of CHE on lipopolysaccharide (LPS)-induced endotoxic shock have not been explored. The aims of the study were to investigate the protective effects of CHE on LPS-induced endotoxic shock in mice and clarify the mechanism of the effects. We found that pretreatment with CHE (1, 5, and 10 mg/kg, po) at 1 and 12 h before injected intraperitoneally with 1 mg/kg LPS markedly decreased the production of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) and attenuated the lung histopathological changes. Meanwhile, the effects were dependent on the inhibition of the expression of p65 nuclear factor κB (NF-κB). The protective effects of CHE on LPS-induced endotoxic shock can be attributed to attenuating inflammatory cytokines and inhibition of the expression of NF-κB.
authors.affiliation: School of Pharmacy, Xi'an Jiaotong University, No. 76 Western Yanta Road, Xi'an, 710061, Shaanxi Province, People's Republic of China, niuxf@mail.xjtu.edu.cn.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Niu
authors.forename: Qingli
authors.initials: Q
authors.lastname: Mu
authors.forename: Weifeng
authors.initials: W
authors.lastname: Li
authors.forename: Huimin
authors.initials: H
authors.lastname: Huang
authors.forename: Huan
authors.initials: H
authors.lastname: Yao
authors.forename: Huani
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D053119:Benzophenanthridines / Q000627:therapeutic use*; D018836:Inflammation Mediators / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D011897:Random Allocation; D012772:Shock, Septic / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D053119:Benzophenanthridines; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; C016299:chelerythrine