title: Lung nodule and functional changes in smokers after smoking cessation short-term treatment.
abstract: BACKGROUND
  Tobacco smoke causes lung disfunction and inflammation.
  
  
  METHODS
  Twenty-two consecutive smokers with undetermined lung nodules were included. All underwent a baseline imaging, exhaled carbon monoxide level evaluation and spirometry, repeated at three months from smoking cessation therapy.
  
  
  RESULTS
  A significant reduction in size of the lung nodules was reported (p = .037) as a trend in number reduction (p = .11). A significant increase in blood arterial oxygen pressure (p < .0001), heart rate reduction (p < .01), and FEV1 increase (p < .0001) was recorded.
  
  
  CONCLUSIONS
  Smoking cessation reduces number and size of lung nodules and improves in lung functionality.
authors.affiliation: Department of Medical Oncology, University Campus Bio-Medico , Rome,1,2.
authors.forename: Eliana
authors.initials: E
authors.lastname: Maci
authors.forename: Francesca
authors.initials: F
authors.lastname: Comito
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Frezza
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tonini
authors.forename: Aldo
authors.initials: A
authors.lastname: Pezzuto
mesh_terms: D002248:Carbon Monoxide / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055613:Multiple Pulmonary Nodules / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012907:Smoking / Q000473:pathology* / Q000503:physiopathology; D016540:Smoking Cessation / Q000379:methods*
chemical_list: D002248:Carbon Monoxide; D010100:Oxygen
keywords: High resolution tomography; Lung nodule evolution; Smoking cessation; Tobacco