title: Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer.
abstract: OBJECTIVE
  To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed.
  
  
  METHODS
  Fifty-two GC and 23 control samples were included.
  
  
  RESULTS
  GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033).
  
  
  CONCLUSIONS
  GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.
authors.affiliation: Translational Cancer Research Department, La Coruña Biomedical Research Institute (INIBIC), Carretera del Pasaje s/n, 15006 La Coruña, Spain.
authors.forename: Moisés
authors.initials: M
authors.lastname: Blanco-Calvo
authors.forename: Nuria
authors.initials: N
authors.lastname: Tarrío
authors.forename: Margarita
authors.initials: M
authors.lastname: Reboredo
authors.forename: Mar
authors.initials: M
authors.lastname: Haz-Conde
authors.forename: Jorge
authors.initials: J
authors.lastname: García
authors.forename: María
authors.initials: M
authors.lastname: Quindós
authors.forename: Angélica
authors.initials: A
authors.lastname: Figueroa
authors.forename: Luis
authors.initials: L
authors.lastname: Antón-Aparicio
authors.forename: Lourdes
authors.initials: L
authors.lastname: Calvo
authors.forename: Manuel
authors.initials: M
authors.lastname: Valladares-Ayerbes
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D018572:Disease-Free Survival; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006801:Humans; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; C533896:MIRN200 microRNA, human; D035683:MicroRNAs; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7
keywords: GDF15; MMP7; biomarkers; diagnostic; gastric cancer; metastasis; miR-200c; prognostic