title: Evaluation of salivary total oxidant-antioxidant status and DNA damage of children undergoing fixed orthodontic therapy.
abstract: OBJECTIVE
  To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy.
  
  
  METHODS
  Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo. The salivary levels of TOS, TAS, and 8-OHdG were determined three times, as follows: before treatment (T1) and at 1 month (T2) and 3 months (T3) following appliance placement. All data were statistically analyzed.
  
  
  RESULTS
  There were no significant differences in TOS, TAS, and 8-OHdG within the same time periods among the three different orthodontic composites (P > .05). TAS in all composite groups decreased over time. These decreases were found to be significant for Kurasper F and GrenGloo at the T1-T3 and T2-T3 time periods (P < .05). In all composite groups 8-OHdG decreased between T1 and T2 (P < .05). However, 8-OHdG in all composite groups increased from T2 to T3. These differences in 8-OHdG were significant in Kurasper F and GrenGloo (P < .05).
  
  
  CONCLUSIONS
  Fixed orthodontic appliances bonded with the tested composites did not increase the cytotoxicity markers in saliva.
authors.affiliation: a Assistant Professor, Ordu University, Faculty of Dentistry, Department of Pediatric Dentistry, Ordu, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Guler
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Toy
authors.forename: Firat
authors.initials: F
authors.lastname: Ozturk
authors.forename: Dilek
authors.initials: D
authors.lastname: Gunes
authors.forename: Aysun Bay
authors.initials: AB
authors.lastname: Karabulut
authors.forename: Onder
authors.initials: O
authors.lastname: Otlu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000180:Acrylic Resins / Q000737:chemistry; D000293:Adolescent; D000975:Antioxidants / Q000032:analysis*; D002648:Child; D003188:Composite Resins / Q000737:chemistry; D004249:DNA Damage; D001840:Dental Bonding; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D008689:Methacrylates / Q000737:chemistry; D016910:Orthodontic Brackets; D016877:Oxidants / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry; D019279:Resin Cements / Q000737:chemistry*; D012463:Saliva / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000975:Antioxidants; D003188:Composite Resins; C472990:Kurasper F; D008689:Methacrylates; D016877:Oxidants; D010756:Phosphoric Acids; D019279:Resin Cements; C477790:Transbond XT; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-Hydroxy-2′-deoxyguanosine; Total antioxidant status; Total oxidant status