title: Plasma orexin-A and ghrelin levels in patients with chronic obstructive pulmonary disease: Interaction with nutritional status and body composition.
abstract: Orexin-A and ghrelin are two important polypeptides that stimulate food intake, however, there is a lack of sufficient information concerning their plasma levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the association between plasma orexin-A and ghrelin levels with food consumption and body composition in patients with stable phase COPD. In total, 40 patients (age, 44-80 years; male, 31; female 9) who were in the stable phase of COPD were included in the study. Blood samples for plasma orexin-A and ghrelin analysis were collected after 8-12 h of fasting; certain anthropometric measurements were obtained and a 24-h dietary recall was recorded. The mean plasma orexin-A levels in the male and female patients were 1.3±0.37 and 1.4±0.13 ng/ml, respectively, while the mean plasma ghrelin levels were 25.9±7.31 and 27.3±8.54 ng/ml, respectively. No significant correlation was observed between the body mass index and plasma orexin-A and ghrelin levels or between the plasma ghrelin levels and dietary nutrient intake (P>0.05). The plasma orexin-A levels were demonstrated to be higher in patients with a higher dietary total fibre intake (r=0.303, P=0.022). A similar correlation was observed between plasma orexin-A levels and dietary intake of soluble (r=0.033, P=0.029) and insoluble (r=0.335, P=0.024) fibre, as well as between the daily consumption of calcium and the levels of plasma orexin-A (r=0.065, P=0.046). Therefore, the results of the present study indicated that a positive correlation existed between dietary nutrient intake and plasma orexin-A levels in patients with COPD.
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Akbulut
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Makbule
authors.initials: M
authors.lastname: Gezmen-Karadağ
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Yasemın
authors.initials: Y
authors.lastname: Ertaş
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Banugül Barut
authors.initials: BB
authors.lastname: Uyar
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Emıne
authors.initials: E
authors.lastname: Yassibaş
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Türközü
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Ferıde
authors.initials: F
authors.lastname: Celebı
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Ozge Tuğçe
authors.initials: OT
authors.lastname: Paşaoğlu
authors.affiliation: Department of Statistics, Hacettepe University, Ankara 06800, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Toka
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Hılal
authors.initials: H
authors.lastname: Yildiran
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey.
authors.forename: Nevın
authors.initials: N
authors.lastname: Sanlier
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Gazi University, Ankara 06560, Turkey.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Köktürk
keywords: anthropometric measurements; chronic obstructive pulmonary disease; diet; ghrelin; orexin-A