title: Can mitochondrial dysfunction be a predictive factor for oxidative stress in patients with obstructive sleep apnea?
abstract: Mitochondrial dysfunction reflects a lifelong cumulative burden of cellular damage, and a decrease in mitochondrial DNA (mtDNA) copy number is associated with oxidative stress and chronic inflammation. The goal of this study was to assess whether mitochondrial dysfunction and a decrease in mtDNA copy number are common features of patients with obstructive sleep apnea syndrome (OSA). We compared mtDNA copy number between 20 healthy volunteers and 20 patients with OSA and investigated whether a significant attenuation of mtDNA copy number was observed in genomic DNA isolated from whole blood of OSA patients. Our observations lead to the hypothesis that mtDNA copy number is lower in whole blood DNA of OSA subjects and might be related to OSA severity, reflecting excessive oxidative stress in patients with OSA.
authors.affiliation: 1 Department of Otolaryngology, Ajou University School of Medicine , Suwon, Korea.
authors.forename: Yoo-Suk
authors.initials: YS
authors.lastname: Kim
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Kwak
authors.forename: Kyu Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Hyun Sang
authors.initials: HS
authors.lastname: Cho
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Lim
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Hoon Shik
authors.initials: HS
authors.lastname: Yang
authors.forename: Hyun Jik
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics; D018628:Gene Dosage / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000473:pathology*; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000235:genetics* / Q000473:pathology*
chemical_list: D004272:DNA, Mitochondrial