title: Memory-T-cell-derived interferon-γ instructs potent innate cell activation for protective immunity.
abstract: Cells of the innate immune system are essential for host defenses against primary microbial pathogen infections, yet their involvement in effective memory responses of vaccinated individuals has been poorly investigated. Here we show that memory T cells instruct innate cells to become potent effector cells in a systemic and a mucosal model of infection. Memory T cells controlled phagocyte, dendritic cell, and NK or NK T cell mobilization and induction of a strong program of differentiation, which included their expression of effector cytokines and microbicidal pathways, all of which were delayed in nonvaccinated hosts. Disruption of IFN-γ signaling in Ly6C+ monocytes, dendritic cells, and macrophages impaired these processes and the control of pathogen growth. These results reveal how memory T cells, through rapid secretion of IFN-γ, orchestrate extensive modifications of host innate immune responses that are essential for effective protection of vaccinated hosts.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Saïdi M'Homa
authors.initials: SM
authors.lastname: Soudja
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Ceena
authors.initials: C
authors.lastname: Chandrabos
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Ernest
authors.initials: E
authors.lastname: Yakob
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Mike
authors.initials: M
authors.lastname: Veenstra
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Palliser
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: gregoire.lauvau@einstein.yu.edu.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Lauvau
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000950:Antigens, Ly; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D018258:Herpesvirus 2, Human / Q000276:immunology; D007113:Immunity, Innate; D007114:Immunization; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009000:Monocytes / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D017471:Receptors, Interferon / Q000235:genetics; D000096743:Interferon gamma Receptor
chemical_list: D000950:Antigens, Ly; D016207:Cytokines; D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor; C494192:Ly-6C antigen, mouse