title: Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose.
abstract: Recent studies have proposed that light emitted by the Cherenkov effect may be used for a number of radiation therapy dosimetry applications. There is a correlation between the captured light and expected dose under certain conditions, yet discrepancies have also been observed and a complete examination of the theoretical differences has not been done. In this study, a fundamental comparison between the Cherenkov emission and absorbed dose was explored for x-ray photons, electrons, and protons using both a theoretical and Monte Carlo-based analysis. Based on the findings of where dose correlates with Cherenkov emission, it was concluded that for x-ray photons the light emission would be optimally suited for narrow beam stereotactic radiation therapy and surgery validation studies, for verification of dynamic intensity-modulated and volumetric modulated arc therapy treatment plans in water tanks, near monoenergetic sources (e.g., Co-60 and brachy therapy sources) and also for entrance and exit surface imaging dosimetry of both narrow and broad beams. For electron use, Cherenkov emission was found to be only suitable for surface dosimetry applications. Finally, for proton dosimetry, there exists a fundamental lack of Cherenkov emission at the Bragg peak, making the technique of little use, although post-irradiation detection of light emission from radioisotopes could prove to be useful.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.
authors.forename: Adam K
authors.initials: AK
authors.lastname: Glaser
authors.forename: Rongxiao
authors.initials: R
authors.lastname: Zhang
authors.forename: David J
authors.initials: DJ
authors.lastname: Gladstone
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
mesh_terms: D004583:Electrons; D008027:Light; D009010:Monte Carlo Method; D055620:Optical Phenomena; D011522:Protons; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy; D011879:Radiotherapy Dosage
chemical_list: D011522:Protons