title: [SIRT2, a multi-talented deacetylase].
abstract: Sirtuin 2 (SIRT2) is an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context. The natural polyphenol resveratrol is known to exert opposite actions on neural cells according to their normal or cancerous status. We have recently shown the involvement of SIRT2 in the antiproliferative effects of resveratrol on primary cultures of human glioblastoma stem cells. SIRT2 could become a new therapeutic target.
authors.affiliation: Équipe plasticité gliale, Neuroscience Paris Seine, CNRS U8246, Inserm U1130, université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France - Laboratoire de génétique et pathologie moléculaire, faculté de médecine et de pharmacie de Casablanca, Maroc.
authors.forename: Salwa
authors.initials: S
authors.lastname: Sayd
authors.affiliation: Équipe plasticité gliale, Neuroscience Paris Seine, CNRS U8246, Inserm U1130, université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Junier
authors.affiliation: Équipe plasticité gliale, Neuroscience Paris Seine, CNRS U8246, Inserm U1130, université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Chneiweiss
mesh_terms: D000818:Animals; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D008136:Longevity / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D056565:Sirtuin 2 / Q000737:chemistry / Q000378:metabolism*
chemical_list: C474199:SIRT2 protein, human; D056565:Sirtuin 2