title: The aetiology of acute neurological decline in multiple sclerosis: experience from an open-access clinic.
abstract: BACKGROUND
  Multiple sclerosis (MS) relapses contribute to disability and influence treatment decisions. Many centres now provide open access to specialist services for patients with new symptoms. However, there is scarce literature on the spectrum of presentations encountered in this setting.
  
  
  OBJECTIVE
  The objective of this paper is to characterise presentations to an open, rapid-access MS relapse clinic and the impact on disease management.
  
  
  METHODS
  A retrospective review of outpatient episodes over a three-year period was conducted. Demographic and service data, symptoms, disability, diagnosis and management were recorded according to a standardised proforma.
  
  
  RESULTS
  A total of 371 attendances were analysed. A new MS relapse was diagnosed in 216 (58%) episodes, of which 56 (26%) patients had an additional diagnosis which had also contributed to their presentation. Of 266 reports of non-relapse-related symptoms, 73 were unrelated to MS. Treatment interventions were made in almost all relapsing patients and in 70% of patients presenting with acute, non-relapse-related symptoms of MS. Changes to disease-modifying therapies were considered in 28% of consultations.
  
  
  CONCLUSIONS
  Diagnosing MS relapses is crucial for disease management and yet remains challenging. Clinicians should be aware of differential diagnoses and confounding factors. The high incidence of therapeutic interventions observed suggests that rapid-access clinics represent an effective platform for responsive disease management.
authors.affiliation: University Hospital of Wales, UK.
authors.forename: Emma C
authors.initials: EC
authors.lastname: Tallantyre
authors.affiliation: Cardiff University, UK.
authors.forename: Emmie G
authors.initials: EG
authors.lastname: Causon
authors.affiliation: University Hospital of Wales, UK/Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University, UK.
authors.forename: Katharine E
authors.initials: KE
authors.lastname: Harding
authors.affiliation: University Hospital of Wales, UK.
authors.forename: Trevor P
authors.initials: TP
authors.lastname: Pickersgill
authors.affiliation: University Hospital of Wales, UK/Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University, UK robertsonnp@cardiff.ac.uk.
authors.forename: Neil P
authors.initials: NP
authors.lastname: Robertson
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000628:therapy; D012008:Recurrence; D012720:Severity of Illness Index
keywords: Multiple sclerosis; acute; clinic; rapid-access; relapse; symptomatic treatment