title: HKOCl-2 series of green BODIPY-based fluorescent probes for hypochlorous acid detection and imaging in live cells.
abstract: A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.
authors.affiliation: Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong, P. R. China.
authors.forename: Jun Jacob
authors.initials: JJ
authors.lastname: Hu
authors.forename: Nai-Kei
authors.initials: NK
authors.lastname: Wong
authors.forename: Qiangshuai
authors.initials: Q
authors.lastname: Gu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Bai
authors.forename: Sen
authors.initials: S
authors.lastname: Ye
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry*; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006997:Hypochlorous Acid / Q000032:analysis* / Q000737:chemistry; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D006997:Hypochlorous Acid