title: Effect of Longbishu capsule () plus doxazosin on benign prostatic hyperplasia: a randomized controlled trial.
abstract: OBJECTIVE
  To investigate the effect of Longbishu Capsule (, LBS), doxazosin, and combination therapy on benign prostatic hyperplasia (BPH).
  
  
  METHODS
  A randomized, double-blind, multi-center parallel trial was conducted involving 360 patients in hospitals in Beijing (108 cases), Heilongjiang (90 cases), Sichuan (90 cases), Shanghai (72 cases), China. They were randomly assigned with central randomization method to group A (LBS placebo plus doxazosin), group B (LBS plus doxazosin) or group C (LBS plus doxazosin placebo), 120 cases for each group. The international prostate symptom score, maximum urinary flow rate, postvoid residual urine volume and prostate volume were measured for evaluating the efficacy of the three treatments.
  
  
  RESULTS
  At baseline, there was no significant difference in the measured variables among the three groups. After 12-month treatment, the three groups showed significant improvements in IPSS and maximum urinary flow rate from baseline (P<0.01). Although postvoid residual urine volume was not significantly different from the baseline in group A (P>0.05), it significantly decreased in group B and C (P<0.05). The incidence of adverse events were similar among the three groups.
  
  
  CONCLUSIONS
  The treatment of LBS alone or LBS plus doxazosin was able to significantly improve IPSS in patients with BPH. The treatments may reduce the increase in prostate volume and postvoid residual urine volume as well.
authors.affiliation: Graduate School of China Academy of Chinese Medical Sciences, Beijing, 100700, China, sonchun@vip.163.com.
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Song
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.forename: De-Gui
authors.initials: DG
authors.lastname: Chang
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Jia-You
authors.initials: JY
authors.lastname: Zhao
authors.forename: Fu
authors.initials: F
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D004311:Double-Blind Method; D017292:Doxazosin / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010919:Placebos; D011470:Prostatic Hyperplasia / Q000188:drug therapy*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D004365:Drugs, Chinese Herbal; D010919:Placebos; C539082:longbixiao; D017292:Doxazosin