title: Role of decidual natural killer cells, interleukin-15, and interferon-γ in placental development and preeclampsia.
abstract: Preeclampsia is a hypertensive, proteinuric disease that affects 5-10% of all pregnancies and is a leading cause of maternal and perinatal morbidity/mortality (Soto et al., J Matern Fetal Neonatal Med 25: 498-507, 2011). The primary treatment for preeclampsia still is delivery of the fetus and placenta. The underlying mechanisms remain elusive. One possibility is inadequate uterine angiogenesis/vascularity (decidualization) at the time of implantation (Torry et al., Am J Reprod Immunol 51: 257-268, 2004). Here, we review evidence for dysregulation of decidual natural killer (dNK) cells, which secrete important angiogenic factors during decidualization, as a contributing factor in preeclampsia.
authors.affiliation: Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York; and.
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Sones
authors.affiliation: Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York; and.
authors.forename: Heinrich E
authors.initials: HE
authors.lastname: Lob
authors.affiliation: Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York; and.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Isroff
authors.affiliation: Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York; and Cell and Developmental Biology, Weill Cornell Medical College, New York, New York robin.davisson@cornell.edu.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Davisson
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology; D003656:Decidua / Q000166:cytology* / Q000502:physiology; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D019409:Interleukin-15 / Q000502:physiology*; D007694:Killer Cells, Natural / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D010920:Placenta / Q000502:physiology*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000502:physiology; D014599:Uterus / Q000098:blood supply
chemical_list: D016207:Cytokines; D019409:Interleukin-15; D012333:RNA, Messenger; D007371:Interferon-gamma
keywords: decidual natural killer cells; placenta; preeclampsia