title: Association between inflammatory biomarkers and adiposity in obese patients with heart failure and metabolic syndrome.
abstract: Obesity, type 2 diabetes mellitus (DM) and metabolic syndrome (MS) are common in patients with heart failure (HF). Studies investigating the association between known biomarkers and adiposity in patient populations are limited. The aim of the present study was to investigate the association between C-reactive protein (CRP) and leptin with adiposity in a sub-group of overweight/obese patients with HF, DM and/or MS. A total of 36 patients (mean age, 56.72±9.78 years; ranging between 27 and 76 years of age; 80.6% male; 52.8% Caucasian) were enrolled and their height, weight, waist circumference and body composition (e.g. percentage body fat and lean mass), as well as the levels of CRP and leptin, were assessed. The results demonstrated that there was a significant association between CRP and leptin, CRP and body mass index (BMI) and gender and percentage body fat (P<0.05, for all associations). Analysis of leptin and CRP levels revealed that patients in the highest BMI quartile (BMI, 40.3-61.2) had higher CRP levels (4.83 μg/ml vs. 3.03 μg/ml; P=0.033) and higher leptin levels (44.97 ng/ml vs. 24.64 ng/ml; P=0.042) compared with patients in the lower BMI quartile (BMI, 28.6-32.4). In conclusion, among obese patients with HF, DM and/or MS, an association between CRP and leptin was identified, providing further evidence that metabolic and inflammatory mechanisms are involved in these diseases. Future investigation to assess the potential impact of inflammation and adiposity, and the role of dietary interventions and weight loss on clinical outcomes in this population of chronically ill patients is warranted.
authors.affiliation: Program of Nursing Science, University of California Irvine, Irvine, CA 92697, CA, USA.
authors.forename: Marjan
authors.initials: M
authors.lastname: Motie
authors.affiliation: Program of Nursing Science, University of California Irvine, Irvine, CA 92697, CA, USA.
authors.forename: Lorraine S
authors.initials: LS
authors.lastname: Evangelista
authors.affiliation: Division of Cardiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles 90095, CA, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Horwich
authors.affiliation: Division of Cardiology, Department of Medicine, University of California Irvine Medical Center, Orange 92868, CA, USA.
authors.forename: Dawn
authors.initials: D
authors.lastname: Lombardo
authors.affiliation: Institute for Clinical and Translational Science, University of California Irvine Medical Center, Orange 92868, CA, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Zaldivar
authors.affiliation: Cedars-Sinai Heart Institute, Los Angeles 90048, CA, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Hamilton
authors.affiliation: Division of Cardiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles 90095, CA, USA.
authors.forename: Gregg C
authors.initials: GC
authors.lastname: Fonarow
keywords: C-reactive protein; biomarkers; heart failure; leptin; obesity