title: Association of dolutegravir and rilpivirine, enhanced by foscarnet induction, in effective salvage antiretroviral therapy.
abstract: We report the case of a multi-experienced patient, infected with an HIV-1 strain, with selected multiple resistance mutations. We designed a novel well-tolerated and effective rescue treatment including dolutegravir, rilpivirine, and foscarnet, allowing a 60-week sustained virological response for the first time in 23 years of HIV infection.
authors.affiliation: Rouen University Hospital, Department of Infectious Diseases, F-76000 Rouen, France.
authors.forename: Jeremie
authors.initials: J
authors.lastname: Leporrier
authors.affiliation: Rouen University Hospital, Department of Infectious Diseases, F-76000 Rouen, France; Normandy University, France; University of Rouen, Institute for Research and Innovation in Biomedicine (IRIB), Research group on antimicrobial agents and microorganisms (GRAM, EA 2656), F-76000 Rouen, France.
authors.forename: Manuel
authors.initials: M
authors.lastname: Etienne
authors.affiliation: Rouen University Hospital, Department of Infectious Diseases, F-76000 Rouen, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Chapuzet
authors.affiliation: APHP, Clinical Pharmacokinetic Department, CHU Bichat-Claude Bernard, F-75018 Paris, France; Paris 7 University, IAME, Inserm UMR 1137, F-75018 Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.affiliation: Rouen University Hospital, Department of Infectious Diseases, F-76000 Rouen, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Bord
authors.affiliation: Rouen University Hospital, Department of Infectious Diseases, F-76000 Rouen, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Borsa-Lebas
authors.affiliation: Rouen University Hospital, Department of Infectious Diseases, F-76000 Rouen, France; Normandy University, France; University of Rouen, Institute for Research and Innovation in Biomedicine (IRIB), Research group on antimicrobial agents and microorganisms (GRAM, EA 2656), F-76000 Rouen, France.
authors.forename: François
authors.initials: F
authors.lastname: Caron
authors.affiliation: Normandy University, France; University of Rouen, Institute for Research and Innovation in Biomedicine (IRIB), Research group on antimicrobial agents and microorganisms (GRAM, EA 2656), F-76000 Rouen, France; Rouen University Hospital, Associate Laboratory of the National Reference Center for HIV, F-76000 Rouen, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Plantier
authors.affiliation: Normandy University, France; University of Rouen, Institute for Research and Innovation in Biomedicine (IRIB), Research group on antimicrobial agents and microorganisms (GRAM, EA 2656), F-76000 Rouen, France; Rouen University Hospital, Associate Laboratory of the National Reference Center for HIV, F-76000 Rouen, France. Electronic address: Thomas.Mourez@univ-rouen.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Mourez
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral; D017245:Foscarnet / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000627:therapeutic use*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D010078:Oxazines; D010879:Piperazines; D011728:Pyridones; D011743:Pyrimidines / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D000068696:Rilpivirine; D016879:Salvage Therapy / Q000379:methods; D055815:Young Adult; D000099226:Dolutegravir
chemical_list: D019380:Anti-HIV Agents; D017245:Foscarnet; D019428:HIV Integrase Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D009570:Nitriles; D010078:Oxazines; D010879:Piperazines; D011728:Pyridones; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; D000068696:Rilpivirine; D000099226:Dolutegravir
keywords: Dolutegravir; Foscarnet; HAART; HIV-1; Rilpivirine; Salvage therapy