title: Pineal tumours: Experience of the French National Register and the Lyon School, results and considerations.
abstract: The experience of the French National Register of pineal tumours and the experience of the Lyon School are reported. Data were collected from 26 French neurosurgical centres from 1989 in Lyons and in other centres from 1997. For radiological and pathological studies, 517 cases were considered while only 452 with sufficient clinical and follow-up data were retained for further analysis. These data highlight the importance of the initial diagnosis for a therapeutic strategy that can be completely different in cases of pineal or germ cell tumours. As regards the latter, chemotherapy and radiotherapy can avoid surgery. Pineocytomas are benign lesions and their complete removal guarantees the cure. Pineal parenchymal tumours with intermediate differentiation (PTT-ID) require complete removal and complementary treatment in cases of histological abnormalities with approximately 66% of patients who remain alive. Pineoblastomas have a poor prognosis and the rate of survival in the French National Register is only 33% of cases. Germinomas can be treated with chemotherapy or radiotherapy alone and generally the indication for surgical removal is limited to residual tumours. The rate of survival is 64% at 10 years. For papillary tumours of the pineal region (PTPR) complete removal is a good prognostic factor. Radiotherapy seems to be effective in cases of residual tumours. The experience and results with radiosurgery treatment have been limited in the French national and Lyon experience.
authors.affiliation: Neurological and Neurosurgical Hospital « P. Wertheimer », 59, boulevard Pinel, 69677 Bron, France. Electronic address: carmine.mottolese@chu-lyon.fr.
authors.forename: C
authors.initials: C
authors.lastname: Mottolese
authors.affiliation: Neurological and Neurosurgical Hospital « P. Wertheimer », 59, boulevard Pinel, 69677 Bron, France.
authors.forename: P A
authors.initials: PA
authors.lastname: Beuriat
authors.affiliation: Neurological and Neurosurgical Hospital « P. Wertheimer », 59, boulevard Pinel, 69677 Bron, France.
authors.forename: A
authors.initials: A
authors.lastname: Szathmari
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000628:therapy*; D010870:Pineal Gland / Q000473:pathology*; D010871:Pinealoma / Q000175:diagnosis / Q000628:therapy*; D016634:Radiosurgery; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Germ cell tumours; Gliomes de la glande pinéale; Papillary tumours French National Register of pineal tumours; Pineal tumours; Pineoblastomas; Pineocytomas; Pinéaloblastomes; Pinéalocytomes; Registre français des tumeurs de la pinéale; Tumeur germinales; Tumeurs papillaires; Tumeurs pinéales