title: Meta-analysis of handsewn versus stapled reversal of loop ileostomy.
abstract: BACKGROUND
  The morbidity associated with closure of loop ileostomy (LI) may be attributed to the various surgical techniques employed for the closure. The purpose of this review was to review the hand-sutured (HS) versus the stapled anastomosis (SA) techniques, used in the reversal of LI.
  
  
  METHODS
  The MEDLINE, PubMed, CINHAL, Cochrane library and Web of Knowledge databases were searched for randomized controlled trials (RCTs) and case-control trials (CCTs), evaluating HS and SA in reversal of LI. Data extraction with risk of bias assessment was followed by subgroup and pooled data meta-analysis where applicable per outcome.
  
  
  RESULTS
  Four RCTs (HS: 321, SA: 328) and 10 CCTs (HS: 2808, SA: 1044) were identified, with a total of 4508 patients. Regardless of subgroup analysis, no difference was seen between the two techniques with regard to anastomotic leaks (P = 0.24, odds ratio (OR): 1.37, 95% confidence interval (CI): 0.81-2.29) or re-operation. The stapled group showed a significantly lower rate of conservatively managed small bowel obstruction (SBO)/ ileus at 30 days (P < 0.001, OR: 2.27, 95% CI: 1.59-2.96) (P < 0.001) and SBO during combined short- and long-term follow-up (P < 0.001). The SA also showed significant shorter operative time (P = 0.02; WMD 11.52 min), time to first bowel opening (P < 0.001; WMD 0.52 days) and length of hospital stay (P = 0.03; WMD 0.70 days).
  
  
  CONCLUSIONS
  The stapled technique offers an advantage in terms of lower post-operative subacute SBO rates, a faster operative technique and shorter hospitalization times. These perceived benefits make it potentially superior to HS for the reversal of LI.
authors.affiliation: Department of Colorectal Surgery, Calderdale and Huddersfield NHS Trust, Huddersfield, UK.
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Markides
authors.forename: Imeshi U
authors.initials: IU
authors.lastname: Wijetunga
authors.forename: Steve R
authors.initials: SR
authors.lastname: Brown
authors.forename: Suhail
authors.initials: S
authors.lastname: Anwar
mesh_terms: D006801:Humans; D007081:Ileostomy; D015233:Models, Statistical; D061646:Operative Time; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000209:etiology; D012086:Reoperation; D017792:Surgical Stapling; D013536:Suture Techniques
keywords: handsewn anastomosis; ileostomy; reversal; stapled anastomosis