title: ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury.
abstract: Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, liver failure, or even death. Antimicrobials and herbal and dietary supplements are among the most common therapeutic classes to cause DILI in the Western world. DILI is a diagnosis of exclusion and thus careful history taking and thorough work-up for competing etiologies are essential for its timely diagnosis. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis and management of DILI with special emphasis on DILI due to herbal and dietary supplements and DILI occurring in individuals with underlying liver disease.
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Naga P
authors.initials: NP
authors.lastname: Chalasani
authors.affiliation: University of North Carolina, Chapel Hill, North Carolina, USA.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Hayashi
authors.affiliation: CarolinasHealthCare System, Charlotte, North Carolina, USA.
authors.forename: Herbert L
authors.initials: HL
authors.lastname: Bonkovsky
authors.affiliation: Einstein Health Care Network, Philadelphia, Pennsylvania, USA.
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Navarro
authors.affiliation: University of Texas at Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Lee
authors.affiliation: University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Fontana
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000628:therapy*; D019587:Dietary Supplements / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D028321:Plant Preparations / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D028321:Plant Preparations