title: Altered maternal proportions of long chain polyunsaturated fatty acids and their transport leads to disturbed fetal stores in preeclampsia.
abstract: Our previous cross-sectional studies have shown altered proportions of long chain polyunsaturated fatty acids (LCPUFA) in preeclampsia (PE) at the end of pregnancy when the pathology has already progressed. The present longitudinal study for the first time reports fatty acid proportions from 16th week of gestation till delivery and placental transport in PE. This is a hospital based study where women were recruited in early pregnancy. Maternal blood was collected at 3 time points i.e. T1=16-20th week, T2=26-30th week and T3=at delivery. Cord blood and placenta were collected at delivery. This study reports data on 140 normotensive control (NC) and 54 PE women. In PE we report lower proportions of DHA in maternal plasma at T1, cord plasma and placenta (p<0.05 for all). The mRNA levels of placental ∆5 desaturase, fatty acid transport proteins -1, -4, were lower (p<0.05 for all) in PE. There was also a positive association between cord and maternal plasma DHA and total omega-3 fatty acids at T1. This study demonstrates that women with PE have lower fatty acids stores at 16-20th week of gestation and lower placental synthesis and transport. It is likely that supplementation of omega-3 fatty acids during the 16-20th week of gestation may help in improving fatty acid status in infants born to mothers with PE.
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Wadhwani
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Patil
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India.
authors.forename: Hemlata
authors.initials: H
authors.lastname: Pisal
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India.
authors.forename: Asmita
authors.initials: A
authors.lastname: Joshi
authors.affiliation: Department of Obstetrics and Gynecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune 411043, India.
authors.forename: Savita
authors.initials: S
authors.lastname: Mehendale
authors.affiliation: Gupte Hospital and Research Centre, Pune, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupte
authors.affiliation: Department of Obstetrics and Gynecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune 411043, India.
authors.forename: Girija
authors.initials: G
authors.lastname: Wagh
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India. Electronic address: srjoshi62@gmail.com.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Joshi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D000090943:Delta-5 Fatty Acid Desaturase; D004281:Docosahexaenoic Acids / Q000097:blood*; D044943:Fatty Acid Desaturases / Q000235:genetics / Q000378:metabolism; D050612:Fatty Acid Transport Proteins / Q000235:genetics / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D008137:Longitudinal Studies; D010920:Placenta / Q000737:chemistry / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D050612:Fatty Acid Transport Proteins; D005227:Fatty Acids; D012333:RNA, Messenger; D004281:Docosahexaenoic Acids; D044943:Fatty Acid Desaturases
keywords: FABP3; FATP1; FATP4; LCPUFA; Δ5 desaturase; Δ6 desaturase