title: Enterocolic lymphocytic phlebitis as a newly recognized manifestation of IgG4-related disease.
abstract: Herein we present a case of a 65-year-old woman with enterocolic lymphocytic phlebitis (ELP) who presented with anemic syndrome and in whom severe stenosis of the right flexure of large bowel was detected. The microscopic examination revealed fibrosis of the submucosa and lymphoplasmacytic phlebitis of small veins and venules, whereas arteries were spared. There were 110 IgG4-positive and 160 IgG-positive plasma cells in 1 high-power field, respectively, with corresponding IgG4/IgG ratio of 0.69. The IgG4 serum level was 2.42 g/L. According to the currently proposed criteria, this ELP case is the first that may be diagnosed as definite IgG4-related disease (IgG4-RD). Although based on the sole case description, taken together with a recent review and a case report, we presume that a subset of ELPs is a manifestation of IgG4-RD.
authors.affiliation: Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic University Hospital, Hradec Kralove, Czech Republic lacoj@lfhk.cuni.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Laco
authors.affiliation: Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic University Hospital, Hradec Kralove, Czech Republic.
authors.forename: Július
authors.initials: J
authors.lastname: Örhalmi
authors.affiliation: Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic University Hospital, Hradec Kralove, Czech Republic.
authors.forename: Jolana
authors.initials: J
authors.lastname: Bártová
authors.affiliation: Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic University Hospital, Hradec Kralove, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Zimandlová
mesh_terms: D000368:Aged; D004760:Enterocolitis / Q000276:immunology*; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000150:complications*; D007074:Immunoglobulin G / Q000276:immunology*; D010689:Phlebitis / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G
keywords: IgG4; IgG4-related disease; bowel; enterocolic lymphocytic phlebitis