title: Pharmacogenetics of antiretroviral therapy.
abstract: BACKGROUND
  Human genetic testing is rapidly entering into most medical disciplines, mainly as a way to predict hereditary conditions including predisposition to cancers or degenerative diseases. Another area of interest for human genomics is to ascertain the therapeutic effect and prevent potential toxicities and/or drug-drug interactions of medication.
  
  
  METHODS
  Several human genotypes have been associated with differences in the metabolism and transport of antiretroviral agents that ultimately affect drug exposure. The accelerated discovery of new gene mutations and polymorphisms that influence the effects of antiretroviral drugs provides a unique opportunity for a personalized medicine approach in the management of lifelong HIV therapy.
  
  
  CONCLUSIONS
  Integration of human genomic screening into HIV clinical management will be cost-effective, maximizing the benefit of drugs with the lowest risk of side effects for a given patient.
authors.affiliation: Hospital Carlos III, Department of Infectious Diseases , Calle Sinesio Delgado 10, Madrid 28029 , Spain vsoriano@dragonet.es.
authors.forename: Pablo
authors.initials: P
authors.lastname: Barreiro
authors.forename: José Vicente
authors.initials: JV
authors.lastname: Fernández-Montero
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
authors.forename: Pablo
authors.initials: P
authors.lastname: Labarga
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001692:Biological Transport / Q000235:genetics; D004347:Drug Interactions / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D009154:Mutation; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D057285:Precision Medicine / Q000379:methods
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; abacavir; antiretrovirals; pharmacogenetics; pharmacogenomics; tenofovir