title: Inflammation-based score (Glasgow prognostic score) as an independent prognostic factor in colorectal cancer patients.
abstract: OBJECTIVE
  This study was conducted to evaluate the systemic inflammatory response in colorectal cancer patients, and to estimate the usefulness of the Glasgow prognostic score (GPS) as a prognostic factor.
  
  
  METHODS
  Patients with biopsy-proven colorectal adenocarcinoma who were operated between April 2005 and December 2008 were enrolled in this study. The GPS was estimated based on the measurement of CRP and serum albumin level. The GPS was compared with other clinicopathological factors. Univariate and multivariate analyses were performed to evaluate the factors affecting cancer-specific survival.
  
  
  RESULTS
  GPS was significantly higher in patients with anemia, thrombocytosis, a high neutrophil to lymphocyte ratio, tumor of the colon, and large tumor. Patient age, gender, serum CEA level, tumor gross appearance, TNM stage, and tumor differentiation were not related with the GPS. In univariate analysis, hemoglobin, CEA, gross appearance of tumor, TNM stage, tumor differentiation, and GPS were associated with cancer-specific survival. In multivariate analysis, TNM stage (III or IV : I or II; hazard ratio [HR], 12.322; P = 0.015), tumor differentiation (poorly differentiated : well or moderately differentiated; HR, 3.112; P = 0.021), and GPS (GPS 2 : GPS 0 or 1; HR, 5.168; P = 0.003) were identified as independent prognostic factors in colorectal cancer.
  
  
  CONCLUSIONS
  Our study showed that the GPS was an independent variable from tumor stage and a good and convenient prognostic factor in colorectal cancer patients.
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: Kyeong Woon
authors.initials: KW
authors.lastname: Choi
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: Seong Woo
authors.initials: SW
authors.lastname: Hong
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: Yeo Goo
authors.initials: YG
authors.lastname: Chang
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: Woo Yong
authors.initials: WY
authors.lastname: Lee
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: Byungmo
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: In Wook
authors.initials: IW
authors.lastname: Paik
authors.affiliation: Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
authors.forename: Hyucksang
authors.initials: H
authors.lastname: Lee
keywords: Colorectal neoplasms; Inflammation; Prognosis