title: Wilms' tumor--lessons and outcomes--a 25-year single center UK experience.
abstract: Wilms' tumor (WT) is a common childhood renal cancer. A 25-year single center UK experience is reported. During 1985-2010, 97 children underwent immediate nephrectomy or delayed resection of tumor after chemotherapy. Survival, morbidity, and late effects following treatment are described. Tumor distribution was: Stage I, 25.7% (n = 25); Stage II, 24.7% (n = 24); Stage III, 26.8% (n = 26); Stage IV, 17.5% (n = 17); and Stage V, 5.2% (n = 5). Immediate nephrectomy was performed in 39% (n = 38) patients with elective delayed resection in 61% (n = 59) cases. Ten patients had cavotomy to excise tumor involving vena cava territory. Two cases required cardiopulmonary bypass. Tumor rupture was recorded in eight (8.5%) total operated cases-after immediate (n = 5/37), 13.5% vs delayed nephrectomy-(n = 3/57), 5.2%; X(2) P = .154. From 2001 onwards, one case of tumor rupture was recorded at this center after the universal adoption of UKW3 and SIOP guidelines advocating preoperative chemotherapy and delayed nephrectomy for all WT. Three treatment-related deaths occurred-hepatic veno-occlusive disease (n = 2) with actinomycin D and a single WT fatality due to vascular injury. Overall survival was 84.5% (82/97 cases). Two patients developed "late malignancies" -thyroid cancer and a basal cell carcinoma. This study demonstrates excellent survival for WT comparable with national outcomes and international cooperative studies. Adverse events with chemotherapy and surgery, including "late onset," second malignancies deserve special consideration.
authors.affiliation: 1Department of Paediatric Surgery, Institute of Child Health, University of Liverpool, Liverpool, UK.
authors.forename: David W
authors.initials: DW
authors.lastname: Fawkner-Corbett
authors.forename: Lisa
authors.initials: L
authors.lastname: Howell
authors.forename: Barry L
authors.initials: BL
authors.lastname: Pizer
authors.forename: Carlo
authors.initials: C
authors.lastname: Dominici
authors.forename: Heather P
authors.initials: HP
authors.lastname: McDowell
authors.forename: Paul D
authors.initials: PD
authors.lastname: Losty
mesh_terms: D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy*; D008297:Male; D009367:Neoplasm Staging; D009392:Nephrectomy; D012189:Retrospective Studies; D015996:Survival Rate; D009396:Wilms Tumor / Q000401:mortality* / Q000473:pathology* / Q000628:therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D003609:Dactinomycin
keywords: Wilms’ tumor; chemotherapy; clinical trials; late effects; outcomes; surgery