title: Advanced technologies applied to physiopathological analysis of central nervous system aneurysms and vascular malformations.
abstract: While depiction and definition of morphological and architectural characteristics of CNS vascular disorders remains the first step of an MR analysis, emerging imaging techniques offer new functional information that might help to characterize rupture risk of CNS vascular disorders. Two main orientations are suggested by recent studies: inflammation of the vessel wall and analysis of physical constraints of blood flow using 4D flow imaging (shear parietal). This paper will focus on radiological application of 4D flow imaging and inflammation imaging, in the characterization of potential prognostic markers of CNS vascular disorders. We will review the basic technical considerations of 4D flow MRA, inflammation imaging and discuss their applications in CNS vascular disorders: aneurysms, arteriovenous malformation, dural arteriovenous fistulas. We will illustrate their potential in the development of individual rupture risk criteria in brain vascular disorders.
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France. Electronic address: m.edjlali@ch-sainte-anne.fr.
authors.forename: M
authors.initials: M
authors.lastname: Edjlali
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Roca
authors.affiliation: Département de neuroradiologie, hôpital universitaire de Montréal, Québec, Canada.
authors.forename: J-C
authors.initials: JC
authors.lastname: Gentric
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Trystram
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez-Régent
authors.affiliation: Département de neurochirurgie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Nataf
authors.affiliation: Département d'anatomopathologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Chrétien
authors.affiliation: Département de physique médicale (O.W.) et de radiologie (P.T.), université du Wisconsin, Madison, Wisconsin, United States.
authors.forename: O
authors.initials: O
authors.lastname: Wieben
authors.affiliation: Département de physique médicale (O.W.) et de radiologie (P.T.), université du Wisconsin, Madison, Wisconsin, United States.
authors.forename: P
authors.initials: P
authors.lastname: Turski
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Meder
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France; Département de neuroradiologie (O.N.), hôpital Necker, AP-HP, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Naggara
authors.affiliation: Département de neuroradiologie, hôpital Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Oppenheim
mesh_terms: D020785:Central Nervous System Vascular Malformations / Q000175:diagnosis / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D011379:Prognosis; D012422:Rupture, Spontaneous; D033081:Shear Strength
keywords: 4D flow MRI; Advanced MR techniques; Brain vascular disorders; Inflammation imaging