title: Measurement of low-density lipoprotein cholesterol in assessment and management of cardiovascular disease risk.
abstract: The deposition of cholesterol in the arterial wall by the infiltration of low-density lipoproteins (LDLs) is a key step in the development of atherosclerosis. In this Commentary, we discuss recent recommendations for clinical laboratory measurement of low-density lipoprotein cholesterol (LDL-C) and its utility both for assessing cardiovascular disease risk and as a tool in the management of patients receiving lipid-lowering therapy.
authors.affiliation: Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, and Department of Internal Medicine, University of California at Davis, Davis, California, USA.
authors.forename: I
authors.initials: I
authors.lastname: Jialal
authors.affiliation: Lipoprotein Metabolism Section, Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Remaley
mesh_terms: D000572:American Heart Association / Q000458:organization & administration*; D002309:Cardiology / Q000458:organization & administration*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors