title: Nerve regeneration and functional recovery by collagen-binding brain-derived neurotrophic factor in an intracerebral hemorrhage model.
abstract: Brain-derived neurotrophic factor (BDNF) exerts therapeutic effects following intracerebral hemorrhage (ICH). However, it is difficult to maintain sufficient concentrations in the hemorrhage hemisphere. We demonstrated previously that BDNF fused to a collagen-binding domain (CBD) could bind to collagen in the ventricular ependyma and stimulate cell proliferation in the subventricular zone (SVZ). In this study, we verified the therapeutic effects of CBD-BDNF in the rat ICH model induced by bacterial collagenase by injecting CBD-BDNF into the lateral ventricle of ICH rats. The results demonstrated that CBD-BDNF was retained at high levels in the hemorrhage hemisphere, where it promoted neural regeneration and angiogenesis, reduced tissue loss, and improved functional recovery.
authors.affiliation: 1 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, People's Republic of China .
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Wenyong
authors.initials: W
authors.lastname: Ding
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Xiao
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhu
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Han
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Weimin
authors.initials: W
authors.lastname: Tong
authors.forename: Jianwu
authors.initials: J
authors.lastname: Dai
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D001929:Brain Edema / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D003094:Collagen / Q000378:metabolism*; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism; D006406:Hematoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009416:Nerve Regeneration / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects; D049268:Positron-Emission Tomography; D011485:Protein Binding / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D011993:Recombinant Fusion Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D020127:Recovery of Function / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D011993:Recombinant Fusion Proteins; D003094:Collagen; D005947:Glucose