title: Individualizing the use of medications in children: making Goldilocks happy.
abstract: To date, implementation of precision medicine for children has been limited. Extrapolation of adult experience streamlines pediatric drug development programs, and physiologically based pharmacokinetic models aid pediatric dose selection on a population basis. To achieve clinically viable individualization of drug therapy, genotype-stratified pharmacokinetic studies can efficiently characterize the extremes of the dose-exposure relationship. Reducing variability in exposure through genotype-based dosing may improve identification of genetic factors contributing to response, ultimately improving drug therapy for children.
authors.affiliation: Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Leeder
authors.affiliation: Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Brown
authors.affiliation: Division of Developmental and Behavioral Sciences, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Soden
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D061214:Patient Safety; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D010641:Phenotype; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D004364:Pharmaceutical Preparations