title: UV spectrophotometric simultaneous determination of paracetamol and ibuprofen in combined tablets by derivative and wavelet transforms.
abstract: The application of first-order derivative and wavelet transforms to UV spectra and ratio spectra was proposed for the simultaneous determination of ibuprofen and paracetamol in their combined tablets. A new hybrid approach on the combined use of first-order derivative and wavelet transforms to spectra was also discussed. In this application, DWT (sym6 and haar), CWT (mexh), and FWT were optimized to give the highest spectral recoveries. Calibration graphs in the linear concentration ranges of ibuprofen (12-32 mg/L) and paracetamol (20-40 mg/L) were obtained by measuring the amplitudes of the transformed signals. Our proposed spectrophotometric methods were statistically compared to HPLC in terms of precision and accuracy.
authors.affiliation: Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam.
authors.forename: Vu Dang
authors.initials: VD
authors.lastname: Hoang
authors.affiliation: Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam.
authors.forename: Dong Thi Ha
authors.initials: DT
authors.lastname: Ly
authors.affiliation: College of Education-Gia Lai, 126 Le Thanh Ton, Pleiku, Gia Lai, Vietnam.
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tho
authors.affiliation: Center for Computational Science and Faculty of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
authors.forename: Hue Minh Thi
authors.initials: HM
authors.lastname: Nguyen
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D007052:Ibuprofen / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013607:Tablets / Q000737:chemistry*; D058067:Wavelet Analysis
chemical_list: D013607:Tablets; D000082:Acetaminophen; D007052:Ibuprofen