title: A rare complication of transitional cell carcinoma of the renal pelvis: parathyroid hormone-related peptide-induced hypercalcaemia.
abstract: We describe a rare occurrence of parathyroid hormone-related peptide (PTHrp) associated hypercalcaemia with a recurrence of transitional cell carcinoma of the renal pelvis. Our patient presented with serum calcium of 3.9 mmol/L, PTH of 5 ng/L and a PTHrp of 9.8 pmol/L (<2 pmol/L). He had no evidence of metastatic disease. His hypercalcaemia responded to bisphosphonate therapy. He chose to be treated conservatively and died 5 weeks after presentation. This is the seventh such case described in the literature. PTHrp-induced hypercalcaemia is associated with a grave prognosis, with a mean survival of 65 days from presentation.
authors.affiliation: Department of Medicine, Cork University Hospital, Cork, Munster, Ireland.
authors.forename: Eoin
authors.initials: E
authors.lastname: O Sullivan
authors.affiliation: Cork University Hospital, Cork, Munster, Ireland.
authors.forename: William
authors.initials: W
authors.lastname: Plant
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007680:Kidney Neoplasms / Q000150:complications*; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications*; D044162:Parathyroid Hormone-Related Protein / Q000502:physiology*
chemical_list: D044162:Parathyroid Hormone-Related Protein