title: Comparative analysis of vaspin in pregnant women with and without gestational diabetes mellitus and healthy non-pregnant women.
abstract: To explore serum vaspin, leptin, and adiponectin levels and their correlation with insulin resistance (IR) in pregnant women with and without gestational diabetes mellitus (GDM) and healthy non-pregnant women. A total of 262 individuals, including pregnant women with GDM (n = 86), those without GDM (n = 92), and age-matched healthy non-pregnant women (n = 84) were enrolled in this case-control study. Vaspin, leptin, adiponectin, glucose, insulin, hemoglobin A1C (HbA1c), and lipid parameters were measured. The homeostasis model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index, and body mass index were calculated. Data inferred higher concentrations of vaspin (2.72 ± 2.20 vs. 1.84 ± 1.57 vs. 0.81 ± 1.02) in GDM than during normal pregnancy and in non-pregnant women, higher leptin (23.42 ± 12.18 vs. 22.19 ± 10.55 vs. 12.10 ± 11.26), and lower adiponectin (4,164.83 ± 2,650.39 vs. 4,871.66 ± 2,803.51 vs. 7,202.85 ± 4,893.13) in GDM and normal pregnancy as compared to non-pregnant women (p < 0.05). Vaspin was positively correlated to leptin (r = 0.273, p = 0.012), HOMA-IR (r = 0.387, p = 0.000), and triglycerides (TG, r = 0.218, p = 0.046) in GDM. In addition, leptin was negatively correlated to adiponectin in GDM (r = -0.336, p = 0.002) and normal pregnancy (r = -0.256, p = 0.014). Furthermore, vaspin was significantly correlated to GDM and HOMA-IR, and the weight gain might play a vital role in the occurrence of GDM. During pregnancy, high vaspin concentration is significantly associated with IR in GDM.
authors.affiliation: Department of Endocrinology, Hebei Medical University, Shijiazhuang, China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Jia
authors.forename: Shuyi
authors.initials: S
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Li
authors.forename: Likui
authors.initials: L
authors.lastname: Guo
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
authors.forename: Yali
authors.initials: Y
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D015843:Serpins / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin; C507339:SERPINA12 protein, human; D015843:Serpins