title: Effects of amisulpride on the cognitive function of patients with schizophrenia who switched from risperidone.
abstract: Objectives. The aims of this 13-week study were to examine the efficacy and safety of amisulpride, and effects on cognitive function in patients with schizophrenia after they switched from risperidone. Methods. Twenty-three patients with schizophrenia whose antipsychotic was switched from risperidone to amisulpride were recruited. The efficacy, safety, and cognitive function were assessed. Results. Significant improvements were noted in the PANSS, CGI-S, and MADRS. The prolactin level, but not any of the remaining laboratory variables, increased significantly. The cognitive function improved significantly, particularly in memory subtests. Conclusions. Switching antipsychotic from risperidone to amisulpride in schizophrenia might have significantly improved not only the efficacy, but also various domains of cognitive function. However, hyperprolactinemia existed and was sometimes even worse.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Wang
authors.forename: Nan-Ying
authors.initials: NY
authors.lastname: Chiu
authors.forename: Shaw-Hwa
authors.initials: SH
authors.lastname: Jou
authors.forename: Yen
authors.initials: Y
authors.lastname: Kuang Yang
authors.forename: I
authors.initials: I
authors.lastname: Hui Lee
authors.forename: Ching-Cheng
authors.initials: CC
authors.lastname: Wang
authors.forename: Kao
authors.initials: K
authors.lastname: Ching Chen
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Liao
keywords: Amisulpride; cognitive function; hyperprolactinemia