title: Biomarkers of coronary artery disease: the promise of the transcriptome.
abstract: The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers. This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification.
authors.affiliation: Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaanes 100 Room G02.523, PO Box 85500, 3508 GA, Utrecht, The Netherlands, M.A.Siemelink@umcutrecht.nl.
authors.forename: Marten Antoon
authors.initials: MA
authors.lastname: Siemelink
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods; D023281:Genomics / Q000379:methods; D006801:Humans; D059467:Transcriptome
chemical_list: D015415:Biomarkers