title: Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells.
abstract: The airway epithelium is exposed to a range of irritants in the environment that are known to trigger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca(2+)-permeable cation channel critical for detecting noxious stimuli by sensory neurons. Recently increasing evidence suggests TRPV1 is also crucially involved in the pathophysiology of asthma on airway epithelium in human. Here we report that in airway epithelial cells TRPV1 activation potently induces allergic cytokine thymic stromal lymphopoietin (TSLP) release. TSLP induction by protease-activated receptor (PAR)-2 activation is also partially mediated by TRPV1 channels.
authors.affiliation: Department of Pathology, Peking University Health Science Center, 100191 Beijing, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Pathology, Peking University Health Science Center, 100191 Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Peking University Health Science Center, 100191 Beijing, China. Electronic address: caoxu@bjmu.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Pathology, Peking University Health Science Center, 100191 Beijing, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Pathology, Peking University Health Science Center, 100191 Beijing, China. Electronic address: zhangbo@bjmu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D001249:Asthma / Q000378:metabolism / Q000473:pathology; D001980:Bronchi / Q000166:cytology* / Q000473:pathology; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D050778:NFATC Transcription Factors / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D050778:NFATC Transcription Factors; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D002118:Calcium; D000094632:Thymic Stromal Lymphopoietin
keywords: Asthma; Nuclear factor of activated T-cells; Protease-activated receptor-2; TRP channel; Thymic stromal lymphopoietin; Transient receptor potential vanilloid 1