title: Improved metabolic response after 16 weeks of calorie-restricted low-glycaemic index diet and metformin in impaired glucose tolerance subjects.
abstract: OBJECTIVE
  This study analyzed the metabolic effects of dietary advice to follow calorie-restricted low-glycaemic index diet with metformin in overweight / obese impaired glucose tolerance subjects.
  
  
  METHODS
  Sixteen subjects with body mass index between 27-38 kg/m² were followed monthly for 16 weeks and treated with metformin (1 g/day) and dietary prescription for low-glycaemic index diet with energy reduction of 25-30% their total energy expenditure. Glucose metabolism, lipid profile, anthropometric and body composition, and food intake parameters were measured before and after the treatment. Paired t-tests/Wilcoxon tests were used to compare differences from baseline, with a statistical significance criterion of p ≤0.05.
  
  
  RESULTS
  There were significant reductions in anthropometric and body composition parameters, decrease in HOMA2-%betaand triglycerides concentrations, and increase in Cederholm index. These results show enhanced peripheral insulin sensitivity and preservation of pan - creatic beta-cell function.
  
  
  CONCLUSIONS
  Calorie-restricted low-glycaemic index diet and metformin was benefit to metabolic and anthropometric parameters in overweight/obese subjects with impaired glucose tolerance.
authors.affiliation: DPhil, Distinguished Professor. Department of Nutrition. University of Brasília. DF. Brasília. Brazil.. caioedureis@gmail.com.
authors.forename: Teresa Helena
authors.initials: TH
authors.lastname: Macedo da Costa
authors.affiliation: MSc, Dietitian. Faculty of Health Science. University of Brasília. DF. Brasília. Brazil..
authors.forename: Fábio Vinícius
authors.initials: FV
authors.lastname: Pires da Silva
authors.affiliation: MSc, Dietitian. Faculty of Health Science. University of Brasília. DF. Brasília. Brazil.. caioedureis@gmail.com.
authors.forename: Caio Eduardo
authors.initials: CE
authors.lastname: Gonçalves Reis
authors.affiliation: PhD, Endocrinologist. Section of Endocrinology. University Hospital of Brasília. DF. Brasília. Brazil..
authors.forename: Luiz
authors.initials: L
authors.lastname: Augusto Casulari
mesh_terms: D000328:Adult; D000886:Anthropometry; D001823:Body Composition; D031204:Caloric Restriction; D004435:Eating; D005260:Female; D018149:Glucose Intolerance / Q000178:diet therapy* / Q000188:drug therapy* / Q000378:metabolism; D038321:Glycemic Index; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin