title: Commentary on Kamper et. al., juvenile traumatic brain injury evolves into a chronic brain disorder: The challenges in longitudinal studies of juvenile traumatic brain injury.
abstract: Juvenile traumatic brain injury (TBI) leaves survivors facing a potential lifetime of cognitive, somatic and emotional symptoms. A recent study published in Experimental Neurology (Kamper et al., 2013) explored the chronic consequences of focal brain injury induced in the juvenile animal, extending their previous observations out to 6months post-injury. The results demonstrate transient, persistent, and late onset behavioral dysfunction, which are associated with subtle evidence for enduring histopathology. In line with investigations about chronic traumatic encephalopathy from brain injury initiated in the adult, juvenile TBI establishes signs of a chronic brain disorder, with unique considerations relative to ongoing developmental processes. This commentary discusses the challenges in evaluating aging with injury in the juvenile population, the current methods of juvenile TBI, and what can be anticipated for the future of the field.
authors.affiliation: College of Health Sciences, Midwestern University, Glendale, AZ, USA; BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, USA.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Ellis
authors.affiliation: BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, USA.
authors.forename: Jenna M
authors.initials: JM
authors.lastname: Ziebell
authors.affiliation: BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, USA; Interdisciplinary Program in Neuroscience, Arizona State University, Phoenix, AZ, USA.
authors.forename: P
authors.initials: P
authors.lastname: David Adelson
authors.affiliation: BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, USA; Phoenix Veteran Affairs Healthcare System, Phoenix, AZ, USA; Interdisciplinary Program in Neuroscience, Arizona State University, Phoenix, AZ, USA. Electronic address: jlifshitz@email.arizona.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lifshitz
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology*; D020208:Brain Injury, Chronic / Q000209:etiology* / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000473:pathology*