title: Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010.
abstract: BACKGROUND
  Our objective was to obtain contemporary lifetime estimates of congenital heart disease (CHD) prevalence using population-based data sources up to year 2010.
  
  
  RESULTS
  The Quebec CHD database contains 28 years of longitudinal data on all individuals with CHD from 1983 to 2010. Severe CHD was defined as tetralogy of Fallot, truncus arteriosus, transposition complexes, endocardial cushion defects, and univentricular hearts. We used latent class bayesian models combining case definitions from physician claims, hospitalization, and surgical data to obtain point and interval prevalence estimates of CHD in the first year of life, in children (<18 years of age) and in adults. We identified 107 559 CHD patients from 1983 to 2010. Prevalence of CHD in the first year of life was 8.21 per 1000 live births (95% confidence interval, 7.47-9.02) from 1998 to 2005. In 2010, overall prevalence of CHD was 13.11 per 1000 (95% confidence interval, 12.43-13.81) in children and 6.12 per 1000 (95% confidence interval, 5.69-6.57) in adults. CHD prevalence increased by 11% in children and 57% in adults from 2000 to 2010. Prevalence in the severe CHD subgroup increased by 19% (95% confidence interval, 17%-21%) in children and 55% (51%-62%) in adults. By 2010, adults accounted for 66% of the entire CHD population.
  
  
  CONCLUSIONS
  With an increase of >50% in CHD prevalence since 2000, by 2010 adults accounted for two thirds of patients with severe and other forms of CHD in the general population. Our findings should inform allocation of resources and the planning of workforce needs for the predominantly adult CHD population.
authors.affiliation: From the McGill Adult Unit for Congenital Heart Disease Excellence (A.J.M., R.I.-I., L.G., M.K.) and Division of Clinical Epidemiology (N.D.), McGill University Health Centre, Montreal, Canada; and Division of Cardiology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.). ariane.marelli@mcgill.ca.
authors.forename: Ariane J
authors.initials: AJ
authors.lastname: Marelli
authors.affiliation: From the McGill Adult Unit for Congenital Heart Disease Excellence (A.J.M., R.I.-I., L.G., M.K.) and Division of Clinical Epidemiology (N.D.), McGill University Health Centre, Montreal, Canada; and Division of Cardiology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.).
authors.forename: Raluca
authors.initials: R
authors.lastname: Ionescu-Ittu
authors.affiliation: From the McGill Adult Unit for Congenital Heart Disease Excellence (A.J.M., R.I.-I., L.G., M.K.) and Division of Clinical Epidemiology (N.D.), McGill University Health Centre, Montreal, Canada; and Division of Cardiology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.).
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Mackie
authors.affiliation: From the McGill Adult Unit for Congenital Heart Disease Excellence (A.J.M., R.I.-I., L.G., M.K.) and Division of Clinical Epidemiology (N.D.), McGill University Health Centre, Montreal, Canada; and Division of Cardiology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.).
authors.forename: Liming
authors.initials: L
authors.lastname: Guo
authors.affiliation: From the McGill Adult Unit for Congenital Heart Disease Excellence (A.J.M., R.I.-I., L.G., M.K.) and Division of Clinical Epidemiology (N.D.), McGill University Health Centre, Montreal, Canada; and Division of Cardiology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.).
authors.forename: Nandini
authors.initials: N
authors.lastname: Dendukuri
authors.affiliation: From the McGill Adult Unit for Congenital Heart Disease Excellence (A.J.M., R.I.-I., L.G., M.K.) and Division of Clinical Epidemiology (N.D.), McGill University Health Centre, Montreal, Canada; and Division of Cardiology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.).
authors.forename: Mohammed
authors.initials: M
authors.lastname: Kaouache
mesh_terms: D000293:Adolescent; D000328:Adult; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D015995:Prevalence; D011792:Quebec / Q000453:epidemiology; D013997:Time Factors
keywords: epidemiology; health services; heart defects, congenital; prevalence