title: Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys.
abstract: Phthalates and BPA are known endocrine disruptors and exposure in pregnant mothers and children is ubiquitous. We explored the relationship of prenatal and childhood exposures with pubertal onset and sex hormones in boys (ages 8-14). Phthalate metabolites and BPA were measured in maternal 3rd trimester or childhood urine. Sex hormones DHEAS, estradiol, inhibin B, SHBG, and total testosterone were measured in serum. Adrenarche and puberty were assessed by pediatrician. Prenatal exposure to some phthalates was associated with decreased DHEAS and inhibin B levels, and with increased SHBG. Prenatal exposure to most phthalates and BPA was associated with greatly reduced odds of adrenarche (odds ratios [OR]=0.12-0.65) and slightly reduced odds of puberty (OR=0.50-0.98). Childhood exposure was not associated with adrenarche or puberty, but some phthalates and BPA were associated with increased SHBG levels and decreased total and free testosterone levels.
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Ferguson
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Peterson
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA; Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, MI, USA; Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Joyce M
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Division of Statistics, Center for Evaluation Research and Surveys, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
authors.forename: Adriana
authors.initials: A
authors.lastname: Mercado-García
authors.affiliation: American British Chowdray (ABC) Hospital, México City, Mexico.
authors.forename: Clara
authors.initials: C
authors.lastname: Blank-Goldenberg
authors.affiliation: Division of Statistics, Center for Evaluation Research and Surveys, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Téllez-Rojo
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Meeker
mesh_terms: D000293:Adolescent; D001559:Benzhydryl Compounds / Q000652:urine*; D002648:Child; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D004958:Estradiol / Q000097:blood; D005260:Female; D005837:Genitalia, Male / Q000033:anatomy & histology; D006801:Humans; D007265:Inhibins / Q000097:blood; D008297:Male; D010636:Phenols / Q000652:urine*; D010795:Phthalic Acids / Q000652:urine*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000652:urine; D011297:Prenatal Exposure Delayed Effects; D011627:Puberty / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D019314:Dehydroepiandrosterone Sulfate; D004785:Environmental Pollutants; D004958:Estradiol; D007265:Inhibins; D010636:Phenols; D010795:Phthalic Acids; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; C422364:inhibin B; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Environment; Exposure; Puberty; Tanner stage; Testosterone