title: [Array comparative genomic hybridization analysis of early-stage arrested human embryos].
abstract: OBJECTIVE
  To investigate chromosomal euploidies in early-stage arrested human embryos.
  
  
  METHODS
  To determine the euploidy status of the 24 chromosomes, 13 embryos were analyzed, which included 5 arrested at 4-cell stage, 4 arrested at 8-cell stage, and 4 embryos at blastocyst stage regardless of their morphological scores. All embryos were subjected to biopsy, whole genome amplification, and array comparative genome hybridization analysis.
  
  
  RESULTS
  Chromosome euploidies of the arrested embryos can be normal, aberrant and chaotic. Mosaicism is prevalent in early stage cleavage, whilst most of the blastocysts, even with poor morphology, are normal diploid.
  
  
  CONCLUSIONS
  Arrested embryo may have normal chromosomes euploidy. Mosaicism is common in cleavage stage embryos. Early stage embryo arrest may not be solely attributable to chromosomal aneuploidies and needs further research.
authors.affiliation: Reproductive Center of the 6th Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510160, P. R. China. Email: fangconggd@163.com.
authors.forename: Chaomin
authors.initials: C
authors.lastname: Yue
authors.forename: Cong
authors.initials: C
authors.lastname: Fang
authors.forename: Lilin
authors.initials: L
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Minfang
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000166:cytology*; D059447:Cell Cycle Checkpoints; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D020964:Embryo Loss / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000235:genetics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy