title: Penifupyrone, a new cytotoxic funicone derivative from the endophytic fungus Penicillium sp. HSZ-43.
abstract: Penifupyrone (1), a new funicone derivative, has been isolated from the endophytic fungus Penicillium sp. HSZ-43, along with three known analogues, funicone (2), deoxyfunicone (3) and 3-O-methylfunicone (4). These structures were identified by using spectroscopic methods, including UV, MS, 1D and 2D NMR experiments. The structure of 1 was confirmed by single-crystal X-ray diffraction analysis. All the isolated compounds were evaluated for cytotoxicity against human oral epidermoid carcinoma KB cells, and compound 1 exhibited moderate cytotoxic activity with IC50 value of 4.7 μM.
authors.affiliation: a College of Chemical and Environmental Engineering, Chongqing Three Gorges University , Chongqing 404100 , P.R. China.
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Chen
authors.forename: Yang-Wu
authors.initials: YW
authors.lastname: Fu
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011753:Pyrones; D029757:Tripterygium / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones; C000594065:funicone; C000594064:penifupyrone
keywords: Penicillium sp; cytotoxic activity; endophytic fungus; secondary metabolites