title: Histopathological and immunohistochemical features of early hydatidiform mole in relation to subsequent development of persistent gestational trophoblastic disease.
abstract: OBJECTIVE
  To examine histomorphological and immunohistochemical findings in hydatidiform moles to determine whether any features can reliably predict clinical behavior.
  
  
  METHODS
  Blinded semiquantitative review of histological and immunohistochemical findings in cases of partial hydatidiform mole (PHM) (N = 50) and complete hydatidiform mole (CHM) which either spontaneously resolved (N = 50) or required chemotherapy (N = 50). Immunostains assessed included MLH1, MSH2, nm23, TERT, p53, EGFR, and CerbB2 based on previous data.
  
  
  RESULTS
  There were marked morphological differences in various criteria between CHMs and PHMs, including the proportion of villi with abnormal trophoblast hyperplasia (29% vs. 6%, respectively). However, there were no significant differences in any morphological parameters between CHMs that spontaneously resolved and those that subsequently required chemotherapy. Similarly, there were no clinically useful differences regarding any immunostaining scores between CHM groups.
  
  
  CONCLUSIONS
  Neither morphological nor immunohistochemical features can reliably predict subsequent requirement of chemotherapy in CHMs.
authors.forename: Gemma
authors.initials: G
authors.lastname: Petts
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Fisher
authors.forename: Dee
authors.initials: D
authors.lastname: Short
authors.forename: Ian
authors.initials: I
authors.lastname: Lindsay
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Sebire
mesh_terms: D000650:Amnion / Q000473:pathology; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000737:chemistry* / Q000473:pathology*; D006801:Humans; D006828:Hydatidiform Mole / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology*; D006965:Hyperplasia; D007150:Immunohistochemistry; D011247:Pregnancy; D014327:Trophoblasts / Q000473:pathology; D014594:Uterine Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology*