title: Immune and anti-oxidant functions of ethanol extracts of Scutellaria baicalensis Georgi in mice bearing U14 cervical cancers.
abstract: BACKGROUND
  The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice.
  
  
  METHODS
  U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-α, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits.
  
  
  RESULTS
  In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-α in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the higher- dose groups of SBGE.
  
  
  CONCLUSIONS
  These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects in U14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.
authors.affiliation: Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University, Qinhuangdao, China E-mail : PY81@sina.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Peng
authors.forename: Cong-Shan
authors.initials: CS
authors.lastname: Guo
authors.forename: Pan-Xia
authors.initials: PX
authors.lastname: Li
authors.forename: Zhan-Zhao
authors.initials: ZZ
authors.lastname: Fu
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Gao
authors.forename: Ya
authors.initials: Y
authors.lastname: Di
authors.forename: Ya-Kun
authors.initials: YK
authors.lastname: Ju
authors.forename: Ru
authors.initials: R
authors.lastname: Tian
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Xue
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003520:Cyclophosphamide / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D007376:Interleukin-2 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008516:Medicine, Chinese Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000097:blood; D031364:Scutellaria baicalensis / Q000378:metabolism*; D013154:Spleen / Q000502:physiology; D013482:Superoxide Dismutase / Q000097:blood; D013950:Thymus Gland / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D016209:Interleukin-8; D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen; C499814:Scutellaria baicalensis extract; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide; D013482:Superoxide Dismutase