title: The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia?
abstract: Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts.
authors.affiliation: Authors' Affiliations: Departments of Medicine; Surgery;
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Lennon
authors.affiliation: Surgery; Pathology; Oncology;
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Wolfgang
authors.affiliation: Authors' Affiliations: Departments of Medicine;
authors.forename: Marcia Irene
authors.initials: MI
authors.lastname: Canto
authors.affiliation: Pathology; Oncology; Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Alison P
authors.initials: AP
authors.lastname: Klein
authors.affiliation: Oncology; Radiation Oncology; and.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Herman
authors.affiliation: Authors' Affiliations: Departments of Medicine; Pathology; Oncology;
authors.forename: Michael
authors.initials: M
authors.lastname: Goggins
authors.affiliation: Radiology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine; and.
authors.forename: Elliot K
authors.initials: EK
authors.lastname: Fishman
authors.affiliation: Radiology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine; and.
authors.forename: Ihab
authors.initials: I
authors.lastname: Kamel
authors.affiliation: Surgery;
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Weiss
authors.affiliation: Oncology;
authors.forename: Luis A
authors.initials: LA
authors.lastname: Diaz
authors.affiliation: Oncology;
authors.forename: Nickolas
authors.initials: N
authors.lastname: Papadopoulos
authors.affiliation: Oncology;
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Kinzler
authors.affiliation: Pathology; Oncology;
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
authors.affiliation: Pathology; Oncology; rhruban@jhmi.edu.
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology / Q000628:therapy; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology / Q000628:therapy; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D008403:Mass Screening; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor