title: Hepatic decompensation in patients with HIV/Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV) triple infection versus HIV/HCV coinfection and the effect of anti-HBV nucleos(t)ide therapy.
abstract: The incidence rate of hepatic decompensation was higher in patients with human immunodeficiency virus (HIV)/hepatitis B virus (HBV)/hepatitis C virus (HCV) triple infection than in those with HIV/HCV coinfection (24.1 vs 10.8 events per 1000 person-years; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.12-3.18). Compared with HIV/HCV-infected patients, the rate of decompensation was increased among HIV/HBV/HCV-infected patients receiving no anti-HBV therapy (HR, 2.48; 95% CI, 1.37-4.49) but not among those who did receive such therapy (HR, 1.09; 95% CI, .40-2.97).
authors.affiliation: Department of Medicine and Penn Center for AIDS Research Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lo Re
authors.affiliation: Analytic Research, STATinMED Research, Dallas, Texas.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: US Outcomes Research, Merck Sharpe and Dohme Corporation, Whitehouse Station, New Jersey.
authors.forename: Scott
authors.initials: S
authors.lastname: Devine
authors.affiliation: Analytic Research, STATinMED Research, Dallas, Texas Department of Economics, Administrative, and Social Sciences, MEF University, Istanbul, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Baser
authors.affiliation: US Outcomes Research, Merck Sharpe and Dohme Corporation, Whitehouse Station, New Jersey.
authors.forename: Temitope
authors.initials: T
authors.lastname: Olufade
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D060085:Coinfection / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D017093:Liver Failure / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009711:Nucleotides / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents; D009711:Nucleotides
keywords: HIV; end-stage liver disease; hepatic decompensation; hepatitis B; hepatitis C