title: [Two cases of sinus histiocytosis with massive cervical lymphadenopathy (Destombes-Rosai-Dorfman disease)].
abstract: BACKGROUND
  Sinus histiocytosis with massive lymphadenopathy is a rare disease. Its location is ubiquitous, but the most frequent is cervical lymph nodes.
  
  
  METHODS
  We report 2 cases of sinus histiocytosis with massive lymphadenopathy. The patients were respectively 9 and 30 years of age. They both presented with bilateral cervical polylymphadenopathy with a cervical compression syndrome in the first patient. The diagnosis was made histologically by demonstrating histiocyte emperipolesis, in the first case, and by immuno-histochemistry in the second. The treatment was corticosteroids, resulting in an almost total involution.
  
  
  CONCLUSIONS
  Sinus histiocytosis with massive lymphadenopathy is a clinical and a specific pathology, but its etiopathogenesis remains to be elucidated. The cervical localization is common. The definitive diagnosis is histological. There is currently no codified treatment. The outcome is usually favorable, apart from mechanical and systemic complications that are important prognostic factors.
authors.affiliation: Service de stomatologie et chirurgie maxillo-faciale, CHU-YO, Ouagadougou, Burkina Faso.
authors.forename: T
authors.initials: T
authors.lastname: Konsem
authors.affiliation: Service d'oto-rhino-laryngologie, CHU-YO, Ouagadougou, Burkina Faso.
authors.forename: R
authors.initials: R
authors.lastname: Wend-Lasida Ouedraogo
authors.affiliation: Service de stomatologie et chirurgie maxillo-faciale, CHU-YO, Ouagadougou, Burkina Faso.
authors.forename: M
authors.initials: M
authors.lastname: Millogo
authors.affiliation: Service d'oto-rhino-laryngologie, CHU-YO, Ouagadougou, Burkina Faso.
authors.forename: Y M C
authors.initials: YM
authors.lastname: Gyebre
authors.affiliation: Service de chirurgie maxillo-faciale, chirurgie plastique esthétique et reconstructrice, chirurgie de la main, centre hospitalo-universitaire, hôpital du Bocage, université de Bourgogne, faculté de médecine, 14, rue Gaffarel, BP 77908, 21079 Dijon cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Bouaichi
authors.affiliation: Service de chirurgie maxillo-faciale, chirurgie plastique esthétique et reconstructrice, chirurgie de la main, centre hospitalo-universitaire, hôpital du Bocage, université de Bourgogne, faculté de médecine, 14, rue Gaffarel, BP 77908, 21079 Dijon cedex, France. Electronic address: nzwetyenga@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Zwetyenga
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage; D002648:Child; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009333:Neck
chemical_list: D001623:Betamethasone; D008775:Methylprednisolone
keywords: Destombes-Rosai-Dorfman disease; Histiocytose sinusale; Histiocytosis; Lymphadénopathie massive; Maladie de Destombes-Rosai-Dorfman; Massive lymphadenopathy; Sinus