title: Glucose-sensitive QCM-sensors via direct surface RAFT polymerization.
abstract: Thin, phenylboronic acid-containing polymer coatings are potentially attractive sensory layers for a range of glucose monitoring systems. This contribution presents the synthesis and properties of glucose-sensitive polymer brushes obtained via surface RAFT polymerization of 3-methacrylamido phenylboronic acid (MAPBA). This synthetic strategy is attractive since it allows the controlled growth of PMAPBA brushes with film thicknesses of up to 20 nm via direct polymerization of MAPBA without the need for additional post-polymerization modification or deprotection steps. QCM-D sensor chips modified with a PMAPBA layer respond with a linear change in the shift of the fundamental resonance frequency over a range of physiologically relevant glucose concentrations and are insensitive toward the presence of fructose, thus validating the potential of these polymer brush films as glucose sensory thin coatings.
authors.affiliation: École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, CH-1015, Lausanne, Switzerland.
authors.forename: Caroline
authors.initials: C
authors.lastname: Sugnaux
authors.forename: H-A
authors.initials: HA
authors.lastname: Klok
mesh_terms: D015374:Biosensing Techniques; D001897:Boronic Acids / Q000737:chemistry; D005947:Glucose / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D058525:Quartz Crystal Microbalance Techniques; D013499:Surface Properties
chemical_list: D001897:Boronic Acids; D008689:Methacrylates; D011108:Polymers; C087935:3-methacrylamidophenylboronic acid; D005947:Glucose
keywords: boronic acid; glucose; polymer brush; quartz crystal microbalance; sensor