title: Phenotype difference between familial and sporadic ankylosing spondylitis in Korean patients.
abstract: Clustered occurrences of ankylosing spondylitis (AS) in family have been noticed. We evaluated patients with AS confirmed by the modified New York criteria for familial history of AS (one or more first to third degree relatives). The clinical characteristics and the recurrence risks (number of AS patients/number of familial members) of the familial AS compared to sporadic AS were investigated. Out of a total of 204 AS patients, 38 patients (18.6%) reported that they had a familial history of AS. The recurrence risks in the familial AS patients for first, second and third degree family members were 14.5%, 5.2%, and 4.4% respectively. Erythrocyte sedimentation rate (ESR) (22.6 ± 22.2 vs 35.4 ± 34.4, P=0.029) and C-reactive protein (CRP) (1.24 ± 1.7 vs 2.43 ± 3.3, P=0.003) at diagnosis, body mass index (21.9 ± 2.7 vs 23.7 ± 3.3, P=0.002) and frequency of oligoarthritis (13.2% vs 33.7%, P=0.021) were significantly lower in the familial form. The presence of HLA-B27 (97.4% vs 83.1%, P=0.044) was significantly higher in familial AS. In conclusion, Korean familial AS patients show a lower frequency of oligoarthritis, lower BMI, lower ESR and CRP at diagnosis and higher presence of HLA-B27.
authors.affiliation: Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.
authors.forename: Hye Won
authors.identifier: 0000-0001-9450-3626
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hye Rim
authors.identifier: 0000-0003-0676-3546
authors.initials: HR
authors.lastname: Choe
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Su Bin
authors.identifier: 0000-0003-0394-1749
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Won Ik
authors.identifier: 0000-0002-5268-290X
authors.initials: WI
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyun Jun
authors.identifier: 0000-0002-9113-6733
authors.initials: HJ
authors.lastname: Chae
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jin Young
authors.identifier: 0000-0002-8688-2205
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jisue
authors.identifier: 0000-0002-7854-285X
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Applied Statistics, Dankook University, Yongin, Korea.
authors.forename: Sungim
authors.identifier: 0000-0001-6636-1077
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yeong Wook
authors.identifier: 0000-0002-5384-3437
authors.initials: YW
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eun Young
authors.identifier: 0000-0001-6975-8627
authors.initials: EY
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000453:epidemiology; D001799:Blood Sedimentation; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003710:Demography; D005190:Family; D005260:Female; D015796:HLA-B27 Antigen / Q000378:metabolism; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012008:Recurrence; D056910:Republic of Korea; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013167:Spondylitis, Ankylosing / Q000175:diagnosis*
chemical_list: D015796:HLA-B27 Antigen; D002097:C-Reactive Protein
keywords: Familial; Phenotype; Recurrence Risk; Spondylitis, Ankylosing; Sporadic