title: Natural killer activity: early days, advances, and seminal observations.
abstract: This manuscript describes the early history of NK cell discovery, with emphasis on the events in the first decade of NK cell studies, 1972-1982. The authors highlight some of the earliest and most important observations that would later prove to be milestones in the study of NK cells and their activity.
authors.affiliation: Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health.
authors.forename: John R
authors.initials: JR
authors.lastname: Ortaldo
authors.affiliation: Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Wiltrout
authors.affiliation: Offlce of the Director, National Cancer Institute, National Institutes of Health.
authors.forename: Craig W
authors.initials: CW
authors.lastname: Reynolds
mesh_terms: D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*