title: [Value of evaluating diastolic function with the single-beat E/(e'×s) obtained by dual doppler echocardiograph in coronary heart disease patients with preserved left ventricular systolic function].
abstract: OBJECTIVE
  To assess the value of E/(e'×s) in estimating left ventricular diastolic dysfunction in patients with coronary heart disease by dual Doppler echocardiograph.
  
  
  METHODS
  Seventy-seven consecutive coronary heart disease patients with preserved systolic function underwent echocardiographic study were included. The E, e'and s were obtained by the dual Doppler echocardiography and E/(e'×s), E/e' were calculated. All patients underwent left ventricular catheterization to measure left ventricular end diastolic pressure (LVEDP). The relationship between E/(e'×s), E/e' and LVEDP were analyzed. Patients were divided into normal diastolic function (LVEDP < 12 mmHg, 1 mmHg = 0.133 kPa) and diastolic dysfunction group (LVEDP ≥ 12 mmHg) .
  
  
  RESULTS
  (1) Pearson correlation analysis showed that both E/(e'×s) and E/e' correlated well with LVEDP (r = 0.68 and r = 0.79, both P < 0.01). (2)Using receiver operating characteristic analysis, the optimal cut-off for E/(e'×s) was 1.2(sensitivity was 80%, specificity was 77%,AUC was 0.85) and for E/e' was 9.2(sensitivity was 74%, specificity was 81%,AUC was 0.87) to predict left ventricular diastolic dysfunction. When combined cut-offs of E/(e'×s) ≥ 1.2 and E/e' ≥ 9.2, the sensitivity and specificity of predicting left ventricular diastolic dysfunction were 83% and 71% respectively, and AUC was 0.87.
  
  
  CONCLUSIONS
  E/(e'×s) can correctly reflect diastolic function status in patients with coronary artery disease. However, combined use of E/(e'×s)and E/e' does not add the prediction value on diastolic dysfunction in this patient cohort.
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email:cyundai@medmail.com.cn.
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Hui
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhi
authors.affiliation: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Mu
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003971:Diastole; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left / Q000502:physiology*