title: Targeting cancer with nano-bullets: curcumin, EGCG, resveratrol and quercetin on flying carpets.
abstract: It is becoming progressively more understandable that different phytochemicals isolated from edible plants interfere with specific stages of carcinogenesis. Cancer cells have evolved hallmark mechanisms to escape from death. Concordant with this approach, there is a disruption of spatiotemproal behaviour of signaling cascades in cancer cells, which can escape from apoptosis because of downregulation of tumor suppressor genes and over- expression of oncogenes. Genomic instability, intra-tumor heterogeneity, cellular plasticity and metastasizing potential of cancer cells all are related to molecular alterations. Data obtained through in vitro studies has convincingly revealed that curcumin, EGCG, resveratrol and quercetin are promising anticancer agents. Their efficacy has been tested in tumor xenografted mice and considerable experimental findings have stimulated researchers to further improve the bioavailability of these nutraceuticals. We partition this review into different sections with emphasis on how bioavailability of curcumin, EGCG, resveratrol and quercetin has improved using different nanotechnology approaches.
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey E-mail : ammadahmad638@yahoo.com.
authors.forename: Aliye
authors.initials: A
authors.lastname: Aras
authors.forename: Abdur Rehman
authors.initials: AR
authors.lastname: Khokhar
authors.forename: Muhammad Zahid
authors.initials: MZ
authors.lastname: Qureshi
authors.forename: Marcela Fernandes
authors.initials: MF
authors.lastname: Silva
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sobczak-Kupiec
authors.forename: Edgardo Alfonso Gomez
authors.initials: EA
authors.lastname: Pineda
authors.forename: Ana Adelina Winkler
authors.initials: AA
authors.lastname: Hechenleitner
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D003474:Curcumin / Q000494:pharmacology*; D004337:Drug Carriers / Q000494:pharmacology; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D064209:Phytochemicals / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry / Q000494:pharmacology; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011794:Quercetin / Q000494:pharmacology*; D000077185:Resveratrol; D012822:Silicon Dioxide; D013267:Stilbenes / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D004337:Drug Carriers; D064209:Phytochemicals; D013267:Stilbenes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011102:Polyhydroxyethyl Methacrylate; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012822:Silicon Dioxide; D002392:Catechin; D011794:Quercetin; C045651:epigallocatechin gallate; D003474:Curcumin; D000077185:Resveratrol