title: Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico.
abstract: Swanson's literature-based discovery focus on resurrecting previously published but neglected knowledge. In this study, we propose a two-step model of the discovery process and generate a hypothesis between anandamide and gastric cancer. Further, the potential relationship was confirmed by follow-up experimentation. The anandamide treatment resulted in cell cycle redistribution of gastric cancer cells. Most importantly, the variation of cell cycle was mediated by some genes from the B-terms of the closed discovery, indicating the potential role of the B-terms. Swanson's literature-based discovery not only collates data for possible interactions, but also provides the potential to observe the larger background behind these direct links and is an invaluable discovery tool for investigators.
authors.affiliation: Department of Oncology, General Hospital of PLA, Beijing, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Peking University Third Hospital, Peking University Health Science Center, Beijing, China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Beijing Centers for Diseases Control and Prevention (CDC) and Centers for Preventive Medical Research, Beijing, China.
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Surgery, PLA 252 Hospital, Baoding, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Mou
authors.affiliation: Department of Oncology, General Hospital of PLA, Beijing, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oncology, General Hospital of PLA, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D063388:Endocannabinoids / Q000494:pharmacology*; D006801:Humans; D063369:Knowledge Discovery / Q000379:methods*; D016239:MEDLINE; D046650:Medical Subject Headings; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology* / Q000523:psychology
chemical_list: D000970:Antineoplastic Agents; D001095:Arachidonic Acids; D063388:Endocannabinoids; D053284:Polyunsaturated Alkamides; C078814:anandamide