title: [Analysis of the causes leading to withdrawal of the treatment with triple antiviral therapy for hepatitis C patients].
abstract: OBJECTIVE
  To assess causes of suspension of hepatitis C treatment in patients receiving triple antiviral therapy (peginterferon+ ribavirin + protease inhibitor).
  
  
  METHODS
  Retrospective observational study of patients who received triple antiretroviral therapy against hepatitis C between January 2012 - March 2013 and discontinued their treatment.
  
  
  RESULTS
  Of 156 patients who initiated therapy, 41 discontinued treatment: Nineteen due to adverse events, being dermatological events in seven patients ( 36.8 %), intolerance in six(31.6%) and hematologic toxicity in four (15.8%) . Sixteen patients discontinued treatment for being ineffectiveness.Patients with higher inefficacy failure rate were "null-responders"(32.3% ) while the group of "relapsers" were the one with the highest rate of toxicity suspensions (15.6%). Two patients died during treatment for pneumonia.
  
  
  CONCLUSIONS
  Triple therapy with boceprevir and telaprevir is associated with a significant number of treatment failures due to toxicity and ineffectiveness.
authors.affiliation: Sevicio de Farmacia. Hospital Universitari i Politècnic. La Fe. Valencia. España.. jrzrms@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz Ramos
authors.affiliation: Sevicio de Farmacia. Hospital Universitari i Politècnic. La Fe. Valencia. España..
authors.forename: L
authors.initials: L
authors.lastname: Lorente Fernández
authors.affiliation: Sevicio de Farmacia. Hospital Universitari i Politècnic. La Fe. Valencia. España..
authors.forename: I
authors.initials: I
authors.lastname: Gil Gómez
authors.affiliation: Sevicio de Farmacia. Hospital Universitari i Politècnic. La Fe. Valencia. España..
authors.forename: M
authors.initials: M
authors.lastname: Cueto Sola
authors.affiliation: Sevicio de Farmacia. Hospital Universitari i Politècnic. La Fe. Valencia. España..
authors.forename: E
authors.initials: E
authors.lastname: Monte Boquet
authors.affiliation: Sevicio de Farmacia. Hospital Universitari i Politècnic. La Fe. Valencia. España..
authors.forename: J L
authors.initials: JL
authors.lastname: Poveda Andrés
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D017211:Treatment Failure; D028761:Withholding Treatment
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations