title: Alterations in cell adhesion proteins and cardiomyopathy.
abstract: Cell adhesive junction is specialized intercellular structure composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clinical and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cellular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models.
authors.affiliation: Jifen Li, Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
authors.forename: Jifen
authors.initials: J
authors.lastname: Li
keywords: Adherens junction; Arrhythmia; Cardiomyopathy; Desmosome; Intercalated disc