title: Elevated serum chemerin in Chinese women with hyperandrogenic PCOS.
abstract: OBJECTIVE
  To compare serum chemerin levels between women with classic hyperandrogenic PCOS, euandrogenic PCOS and matched control subjects.
  
  
  METHODS
  This study was carried out at the Second XiangYa Hospital between July 2012 and April 2013. Sixty-seven women with PCOS and 20 controls were included. Blood pressure, body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting plasma glucose and blood serum hormone and blood lipid were measured. Transvaginal ultrasound was performed. Serum chemerin was measured by ELISA.
  
  
  RESULTS
  Serum chemerin was significantly higher in classic hyperandrogenic PCOS compared with euandrogenic PCOS and controls (311.07 ± 141.87 ng/mL versus 228.03 ± 119.66 ng/mL and 225.87 ± 86.44 ng/mL, p < 0.05). Serum chemerin was positively related to follicle count, ovarian volume, the level of testosterone, luteinizing hormone/follicle-stimulating hormone, low-density lipoprotein, triglycerides, fasting blood insulin, insulin resistance by homeostasis model assessment, WHR and BMI, while negatively related to the level of high-density lipoprotein. Multiple linear regression analyses revealed ovarian volumes and WHR were the significant influencing factors of chemerin (p < 0.05). The area under the receiver operating characteristic curve for chemerin reached a value of 0.684 (0.572-0.796, 95% confidence interval). The best compromise between sensitivity (80.0%) and specificity (47.6%) was obtained with a cutoff value of 200.94 ng/mL.
  
  
  CONCLUSIONS
  Serum chemerin level was increased in Chinese women with classic hyperandrogenic PCOS. Serum chemerin measurement offers a relatively moderate diagnostic potency with a sensitivity of 80.0% and a specificity of 47.6% at 200.94 ng/mL. This suggested that chemerin may be involved in the development of the metabolic syndrome of classic PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, The Second XiangYa Hospital of Central South University , Hunan , China.
authors.forename: LiQiong
authors.initials: L
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhong
authors.forename: YiLing
authors.initials: Y
authors.lastname: Ding
authors.forename: XiaoBo
authors.initials: X
authors.lastname: Shi
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: FuFan
authors.initials: F
authors.lastname: Zhu
mesh_terms: D000328:Adult; D018925:Chemokines / Q000097:blood*; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000453:epidemiology; D036341:Intercellular Signaling Peptides and Proteins; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human
keywords: Chemerin; Chinese woman; hyperandrogenism; metabolic syndrome; polycystic ovary syndrome