title: Intravenous administration and abuse of bupropion: a case report and a review of the literature.
abstract: BACKGROUND
  Bupropion is an effective and well-tolerated second-generation antidepressant generally assumed to be without abuse potential. In the past years, several case reports about the recreational use of bupropion, mainly via nasal insufflation, have been published. Last year, a first case of intravenous bupropion dependence was reported.
  
  
  METHODS
  We present another case of intravenous administration of and dependence on bupropion in a 29-year-old woman with a history of polysubstance dependence, who consumed an extremely high daily dose of about 2400 mg of bupropion together with a daily oral dose of 2400 to 3600 mg of pregabalin.
  
  
  CONCLUSIONS
  The possible impact of bupropion on subjects with a history of polysubstance dependence is discussed; physicians should be careful when prescribing bupropion in these cases.
authors.affiliation: From the Department of Psychiatry and Psychotherapy (KO, GK, OP) and the Department of Neurology (AZ), Ludwig-Maximilians-University Munich, Munich, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Oppek
authors.forename: Gabriele
authors.initials: G
authors.lastname: Koller
authors.forename: Andreas
authors.initials: A
authors.lastname: Zwergal
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
mesh_terms: D000293:Adolescent; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000009:adverse effects*; D016642:Bupropion / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015819:Substance Abuse, Intravenous; D055815:Young Adult
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion