title: Age of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty.
abstract: OBJECTIVE
  Gonadotropin-releasing hormone agonist (GnRHa) is known for improving final adult height in patients with central precocious puberty (CPP). This study aimed to investigate the age of menarche and near adult height in girls with CPP who had been treated with GnRHa.
  
  
  METHODS
  In this retrospective study, we reviewed the medical records of 71 Korean girls with CPP who had started menarche or reached over 13 years of bone age after long-term GnRHa treatment. We estimated near adult height using the Bayley-Pinneau method and identified the age of menarche in girls with CPP.
  
  
  RESULTS
  Mean chronological and bone age at menarche were 11.9±0.7 and 12.8±0.4 years, respectively. The period between menarche and the end of treatment was 14.0±5.6 months. Posttreatment near adult height was 163.8±4.7 cm, which was significantly greater than pretreatment predicted adult height (158.7±4.1 cm).
  
  
  CONCLUSIONS
  GnRHa treatment in girls with CPP could improve final adult height and made the age of menarche close to that of the general population.
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Joon-Woo
authors.initials: JW
authors.lastname: Baek
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyo-Kyoung
authors.initials: HK
authors.lastname: Nam
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Dahee
authors.initials: D
authors.lastname: Jin
authors.affiliation: Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
authors.forename: Yeon Joung
authors.initials: YJ
authors.lastname: Oh
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Young-Jun
authors.initials: YJ
authors.lastname: Rhie
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Kee-Hyoung
authors.initials: KH
authors.lastname: Lee
keywords: Central; Gonadotropin-releasing hormone; Menarche; Precocious puberty