title: Repositioning monocyte TFRN into fibroblasts.
abstract: Repositioning of cell-specific Transcription Factor Regulatory Networks (TFRNs) into another cell type is a pragmatic approach to elicit desired functions in impaired cells and also to investigate transcription regulations underlying cellular functions. However, a systematic method to identify a set of transcription factors (TFs) which can efficiently promote TFRN in a foreign cell type is lacking. Here, we demonstrate a perturbation-matrix method for the identification and repositioning of monocyte TFRNs in dermal fibroblasts.
authors.affiliation: Division of Genomics Technologies, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Jay W
authors.initials: JW
authors.lastname: Shin
authors.forename: Harukazu
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D009000:Monocytes / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014161:Transduction, Genetic / Q000379:methods
chemical_list: D014157:Transcription Factors