title: A prospective randomized clinical evaluation of 3 presbyopia-correcting intraocular lenses after cataract extraction.
abstract: OBJECTIVE
  To compare contrast sensitivity, visual acuity (VA), and halos in subjects bilaterally implanted with 1 of 3 FDA-approved presbyopia-correcting intraocular lenses.
  
  
  METHODS
  Prospective, randomized, partially masked, multicenter clinical trial.
  
  
  METHODS
  Seventy-eight subjects were randomized sequentially for bilateral implantation with the Crystalens AO (Bausch & Lomb Surgical), AcrySof IQ ReSTOR +3.0 (Alcon Laboratories), or Tecnis Multifocal (Abbott Medical Optics) lenses. Subjects were evaluated through visit 4 (4 to 6 months after surgery) with the following monocular and binocular assessments: high- and low-contrast VA, contrast sensitivity without glare, halos or starbursts, defocus curves, optical scatter, retinal point spread function, and safety.
  
  
  RESULTS
  The Crystalens AO and ReSTOR +3.0 demonstrated better monocular and binocular contrast sensitivity without glare at low to mid spatial frequencies compared with the Tecnis Multifocal lens. Binocular uncorrected distance VA was not significantly different between the 3 lenses. The Crystalens AO had significantly better binocular low-contrast distance-corrected VA than the ReSTOR +3.0 and better mean monocular low-contrast DCVA than the Tecnis Multifocal lens. The Crystalens AO demonstrated significantly better monocular and binocular uncorrected and distance-corrected intermediate VA than the ReSTOR +3.0 or Tecnis Multifocal lenses. The ReSTOR+3.0 lens had significantly better monocular and binocular uncorrected and distance-corrected near VA tested at 40 cm compared with the Crystalens AO and Tecnis Multifocal lens. The Crystalens AO elicited significantly less halos than the Tecnis Multifocal lens and less optical scatter than the ReSTOR +3.0 or Tecnis Multifocal lens.
  
  
  CONCLUSIONS
  The Crystalens AO had statistically better uncorrected intermediate VA and distance-corrected intermediate VA than the ReSTOR +3.0 or Tecnis Multifocal lenses and fewer photic phenomenon than the Tecnis Multifocal lens. Both multifocals had better distance-corrected near VA and uncorrected near VA than the Crystalens AO. These findings may guide intraocular lens selection for individual patients seeking to optimize vision at specific vergences or lighting conditions.
authors.affiliation: Pepose Vision Institute and the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri. Electronic address: jpepose@peposevision.com.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Pepose
authors.affiliation: Pepose Vision Institute and the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Mujtaba A
authors.initials: MA
authors.lastname: Qazi
authors.affiliation: Chu Eye Associates, Fort Worth, Texas.
authors.forename: Richard
authors.initials: R
authors.lastname: Chu
authors.affiliation: Durrie Vision, Overland Park, Kansas.
authors.forename: Jason
authors.initials: J
authors.lastname: Stahl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D015350:Contrast Sensitivity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011305:Presbyopia / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D011474:Prosthesis Design; D012029:Refraction, Ocular; D016037:Single-Blind Method; D016896:Treatment Outcome; D014792:Visual Acuity