title: Clear cell adenocarcinoma arising in an adenomyoma of the broad ligament.
abstract: Extrauterine adenomyomas are extremely rare benign tumors of smooth muscles, endometrial glands, and endometrial stroma. Ectopic endometrial glands can undergo malignant change. The ovary is the most common site of malignant change in endometriosis. Cancer arising in extraovarian endometriosis is a rare event with limited cases in the literature. To the best of our knowledge, we present the first case of a clear cell adenocarcinoma arising from foci of ectopic endometrial tissue in an adenomyoma of the broad ligament. It supports the association between endometriomas and clear cell adenocarcinoma. Therefore, patients with a significant history of endometriosis may benefit from close follow-up or definitive surgery.
authors.affiliation: University of Louisville, Louisville, KY, USA d0torr02@louisville.edu.
authors.forename: Diogo
authors.initials: D
authors.lastname: Torres
authors.affiliation: University of Louisville, Louisville, KY, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Parker
authors.affiliation: University of Louisville, Louisville, KY, USA.
authors.forename: Mana
authors.initials: M
authors.lastname: Moghadamfalahi
authors.affiliation: University of Louisville, Louisville, KY, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Sanders
authors.affiliation: University of Louisville, Louisville, KY, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Metzinger
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D018194:Adenomyoma / Q000473:pathology*; D001956:Broad Ligament / Q000473:pathology*; D004715:Endometriosis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000473:pathology*
keywords: adenomyoma; broad ligament; clear cell adenocarcinoma; clear cell carcinoma; extraovarian endometriosis; ovarian cancer