title: Evaluation of the neuroprotective activity of stansin 6, a resin glycoside from Ipomoea stans.
abstract: Stansin 6 a tetrasaccharide resin glycoside isolated from the root of Ipomoea stans was evaluated as anticonvulsant and neuroprotective in kainic acid-induced seizures of rats. Intraperitoneal injection of kainic acid (10 mg/kg) induced typical behavioral seizures such as wet dog shakes and limbic seizures, and histopathological changes in the hippocampus (degeneration and loss of pyramidal cells in CA1 to CA4 areas). Stansin 6 (10-80 mg/kg) had no effect on the behavior of rats and did not induce hippocampal damage. Pretreatment with stansin 6 inhibited convulsions in rats from kainic acid-induced seizures, reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by kainic acid. These results suggest that stansin 6 possesses neuroprotective and anticonvulsant activities.
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico. Electronic address: ismaelr@uaem.mx.
authors.forename: Ismael
authors.initials: I
authors.lastname: León-Rivera
authors.affiliation: Laboratorio Experimental de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, MVS, SSA. Insurgentes Sur 3877, Col. La Fama 14269 Distrito Federal, Mexico.
authors.forename: Juana
authors.initials: J
authors.lastname: Villeda-Hernández
authors.affiliation: Laboratorio de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, MVS, SSA. Insurgentes Sur 3877, Col. La Fama 14269 Distrito Federal, Mexico.
authors.forename: Victoria
authors.initials: V
authors.lastname: Campos-Peña
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: Alma
authors.initials: A
authors.lastname: Aguirre-Moreno
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: Samuel
authors.initials: S
authors.lastname: Estrada-Soto
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Navarrete-Vázquez
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: María Yolanda
authors.initials: MY
authors.lastname: Rios
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: Berenice
authors.initials: B
authors.lastname: Aguilar-Guadarrama
authors.affiliation: Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Castillo-España
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
authors.forename: Julio César
authors.initials: JC
authors.lastname: Rivera-Leyva
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D027741:Ipomoea / Q000737:chemistry*; D007608:Kainic Acid / Q000008:administration & dosage; D008968:Molecular Conformation; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D006017:Glycolipids; D018696:Neuroprotective Agents; C000595767:stansin 6; D007608:Kainic Acid
keywords: Anticonvulsant; Astrocytes; Ipomoea stans; Neuroprotective; Resin glycoside