title: Splanchnic Tissue Oxygenation for Predicting Feeding Tolerance in Preterm Infants.
abstract: BACKGROUND
  Feeding intolerance is very frequent in preterm infants, and the development of an early effective biomarker for its prediction could be useful for carrying out a proper feeding strategy. Our aim was to evaluate if the measurement of splanchnic regional oxygenation (rSO2S) and splanchnic fractional oxygen extraction ratio (FOES) using near-infrared spectroscopy (NIRS) is correlated with the time needed to achieve full enteral feeding and if it can predict the development of feeding intolerance.
  
  
  METHODS
  We measured rSO2S and FOES in preterm infants 25 ± 0 to 31 ± 6 weeks of gestational age at 24-72 hours of life during continuous enteral feeding.
  
  
  RESULTS
  Linear regression analysis did not evidence any relationship between rSO2S and FOES and the time for achievement of full enteral feeding. Multivariate logistic regression analysis showed that birth weight <1000 g (relative risk [RR], 4.5; 95% confidence interval [CI], 1.23-16.45) and patent ductus arteriosus occurrence (RR, 9.3; 95% CI, 1.31-66.06) increased the risk of developing feeding intolerance in our population.
  
  
  CONCLUSIONS
  Splanchnic oxygenation and oxygen extraction measured in the first days of life are not correlated with the time needed to achieve full enteral feeding in preterm infants receiving continuous enteral nutrition.
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Children's Health, University of Florence, Italy cdani@unifi.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Dani
authors.affiliation: Careggi University Hospital of Florence, Florence, Italy.
authors.forename: Iuri
authors.initials: I
authors.lastname: Corsini
authors.affiliation: Careggi University Hospital of Florence, Florence, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Generoso
authors.affiliation: Careggi University Hospital of Florence, Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Gozzini
authors.affiliation: Careggi University Hospital of Florence, Florence, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bianconi
authors.affiliation: Careggi University Hospital of Florence, Florence, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Pratesi
mesh_terms: D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D004373:Ductus Arteriosus; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000517:prevention & control; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D008297:Male; D010100:Oxygen / Q000097:blood*; D010288:Parenteral Nutrition; D015203:Reproducibility of Results; D012307:Risk Factors; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013152:Splanchnic Circulation; D013997:Time Factors
chemical_list: D015415:Biomarkers; D010100:Oxygen
keywords: continuous feeding; feeding tolerance; near infrared spectroscopy; preterm infants