title: Determination of acetylsalicylic acid in commercial tablets by SERS using silver nanoparticle-coated filter paper.
abstract: In this work, filter paper was used as a low cost substrate for silver nanoparticles in order to perform the detection and quantification of acetylsalicylic acid by SERS in a commercial tablet. The reaction conditions were 150mM of ammonium hydroxide, 50mM of silver nitrate, 500mM of glucose, 12min of the reaction time, 45°C temperature, pretreatment with ammonium hydroxide and quantitative filter paper (1-2μm). The average size of silver nanoparticles deposited on the paper substrate was 180nm. Adsorption time of acetylsalicylic acid on the surface of the silver-coated filter paper was studied and an adsorption time of 80min was used to build the analytical curve. It was possible to obtain a calibration curve with good precision with a coefficient of determination of 0.933. The method proposed in this work was capable to quantify acetylsalicylic acid in commercial tablets, at low concentration levels, with relative error of 2.06% compared to the HPLC. The preparation of filter paper coated with silver nanoparticles using Tollen's reagent presents several advantages such as low cost of synthesis, support and reagents; minimum amount of residuals, which are easily treated, despite the SERS spectroscopy presenting fast analysis, with low sample preparation and low amount of reactants as in HPLC analysis.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970 São Carlos, SP, Brazil.
authors.forename: Loriz Francisco
authors.initials: LF
authors.lastname: Sallum
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970 São Carlos, SP, Brazil.
authors.forename: Frederico Luis Felipe
authors.initials: FL
authors.lastname: Soares
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970 São Carlos, SP, Brazil.
authors.forename: Jorge Armando
authors.initials: JA
authors.lastname: Ardila
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, C.P. 676, 13560-970 São Carlos, SP, Brazil. Electronic address: renato.lajarim@ufscar.br.
authors.forename: Renato Lajarim
authors.initials: RL
authors.lastname: Carneiro
mesh_terms: D000327:Adsorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D001241:Aspirin / Q000032:analysis*; D005374:Filtration / Q000379:methods*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008958:Models, Molecular; D010209:Paper; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D012834:Silver; D001241:Aspirin
keywords: Acetylsalicylic acid; SERS; Silver nanoparticles-coated filter paper; Tollen’s reagent