title: The role of MALAT1 correlates with HPV in cervical cancer.
abstract: Cervical cancer, the second most common type of cancer in women worldwide, is responsible for >275,100 mortalities each year and is associated with high-risk human papilloma virus (HR-HPV). HPVs have two important oncogenes, E6 and E7, which have crucial roles in malignant transformation in cervical cancer. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA originally identified in non-small cell lung cancer. Previous studies have revealed that MALAT1 is expressed in numerous tissue types, and is significant in maintaining the normal function of the body. However, it also appeared to be notably upregulated in numerous carcinoma types compared with adjacent non-cancerous tissues. In the present study, it was identified that MALAT1 expression was upregulated in cervical cancer cell lines compared with normal cervical squamous cell samples. Further study into the effect of MALAT1 on cellular phenotype revealed that MALAT1 was able to promote cell migration and proliferation. Of note, it was revealed that the expression of MALAT1 was decreased with the knockdown of HPV16 E6/E7 in CaSki cells. Furthermore, the investigations in clinical samples also revealed that MALAT1 was expressed in HPV-positive cervical squamous cells, but not in HPV-negative normal cervical squamous cells. These results indicate that HPV correlates with MALAT1 deregulation in cervical cancer.
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Fang
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Binyuan
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Changfei
authors.initials: C
authors.lastname: Qin
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Pingli
authors.initials: P
authors.lastname: Xie
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Cancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
authors.forename: Guancheng
authors.initials: G
authors.lastname: Li
keywords: cell proliferation; cervical cancer; human papilloma virus; metastasis-associated lung adenocarcinoma transcript 1