title: Elevated plasma paroxetine concentrations in a patient treated with a combination of paroxetine and pindolol.
abstract: Paroxetine and pindolol have been used in combination to augment the antidepressant response of SSEIs. The rationale given involves the prevention of a negative feedback inhibition of serotonergic neurons but few studies have addressed potential pharmacokinetic interactions. This paper reports on elevated plasma paroxetine concentrations in a 37-year-old depressed woman following the introduction of pindolol. This case study supports the possibility of competitive drug-drug interactions in combinations of paroxetine and pindolol.
authors.affiliation: Department of Psychiatry, Austin.
authors.forename: J S
authors.initials: JS
authors.lastname: Olver
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
keywords: Andole; Depression; Paroxetine; drug interactions; plasma concentrations