title: Cytotoxic compounds from the leaves of Garcinia polyantha.
abstract: A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.
authors.affiliation: Department of Organic Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon, (phone: +237-77-534830; fax: +237-22-229116); Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld. alainmeli@yahoo.com.
authors.forename: Alain Meli
authors.initials: AM
authors.lastname: Lannang
authors.forename: Simplice J N
authors.initials: SJ
authors.lastname: Tatsimo
authors.forename: Hugues
authors.initials: H
authors.lastname: Fouotsa
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Dzoyem
authors.forename: Ajit Kumar
authors.initials: AK
authors.lastname: Saxena
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings; D044004:Xanthones
keywords: Antiproliferative activity; Garcinia polyantha; Xanthones