title: Urinary biomarkers of acute kidney injury in patients with liver cirrhosis.
abstract: OBJECTIVE
  Acute kidney injury is a common complication in cirrhotic patients. Serum creatinine is a poor biomarker for detection of renal impairment in cirrhotic patients. The aim of this study was to evaluate Urinary Neutrophils Gelatinase-Associated Lipocalin (NGAL) and Urinary interleukin-18 (IL-18) as early biomarkers of acute kidney injury in cirrhotic patients.
  
  
  METHODS
  160 cirrhotic patients was enrolled in this study divided into 3 main groups according to presence or absence of ascites and renal impairment.
  
  
  RESULTS
  Significant elevation of both Urinary NGAL and Urinary IL-18 in cirrhotic patients with renal impairment especially in patients with Acute tubular necrosis (ATN) was observed. AUROC was (0.909) with (sensitivity 95.5%, specificity 76.1) for Urinary NGAL and AUROC was (0.975), with (sensitivity 95.5%, specificity 91.3%) for Urinary IL-18.
  
  
  CONCLUSIONS
  Both Urinary NGAL and Urinary IL-18 can act as urinary biomarkers of acute kidney injury in cirrhotic patient.
authors.forename: Qasem Anass
authors.initials: QA
authors.lastname: Ahmed
authors.forename: Farag Salama
authors.initials: FS
authors.lastname: El Sayed
authors.forename: Hamed
authors.initials: H
authors.lastname: Emad
authors.forename: Emara
authors.initials: E
authors.lastname: Mohamed
authors.forename: Bihery
authors.initials: B
authors.lastname: Ahmed
authors.forename: Pasha
authors.initials: P
authors.lastname: Heba
mesh_terms: D058186:Acute Kidney Injury / Q000652:urine*; D000209:Acute-Phase Proteins / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000652:urine*; D007677:Kidney Function Tests; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008103:Liver Cirrhosis / Q000652:urine*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000652:urine*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D020382:Interleukin-18; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins