title: Nuclear PI5P, Uhrf1, and the road not taken.
abstract: In this issue of Molecular Cell, Gelato et al. (2014) identify the signaling molecule phosphatidylinositol 5-phosphate (PI5P) as an allosteric regulator that determines the mode of chromatin binding for the DNA methylation maintenance factor Uhrf1. This work links nuclear lipids to chromatin signaling in the maintenance of DNA methylation and epigenetic regulation.
authors.affiliation: Department of Biology, Stanford University, Stanford, CA 94305, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Reynoird
authors.affiliation: Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: ogozani@stanford.edu.
authors.forename: Or
authors.initials: O
authors.lastname: Gozani
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins / Q000737:chemistry*; D006657:Histones / Q000737:chemistry*; D006801:Humans; D018129:Phosphatidylinositol Phosphates / Q000737:chemistry*; D044767:Ubiquitin-Protein Ligases
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D006657:Histones; D018129:Phosphatidylinositol Phosphates; C113567:phosphatidylinositol 5-phosphate; C406364:UHRF1 protein, human; D044767:Ubiquitin-Protein Ligases