title: [Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesity among children and adolescents].
abstract: OBJECTIVE
  To study the relationship between rs2228314 polymorphism in sterol regulatory element binding protein 2 gene (SREBP2) and obesity, serum lipid levels in children and adolescents.
  
  
  METHODS
  In our study, 2 030 children and adolescents aged from 7 to 18 years participated. Anthropometric measurements, including height and weight, were performed. Their serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected. The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to detect rs2228314 genotypes.
  
  
  RESULTS
  The GC/CC genotypes of rs2228314 polymorphisms had lower HDL-C levels than GG genotype [(0.10 ± 0.35) mmol/L vs. (0.14 ± 0.36) mmol/L, P=0.020]. The rs2228314 polymorphism was associated with the abnormal HDL-C level under the dominant model after adjustment for study samples, sex and age (OR=1.400, 95% CI: 1.027-1.907, P=0.033). The rs2228314 polymorphism was not associated with obesity under the dominant model after adjustment for study samples, sex, age and HDL-C level (OR=1.178,95% CI: 0.971-1.430, P=0.096).
  
  
  CONCLUSIONS
  The GC/CC genotype carriers of SREBP2 rs2228314 polymorphism have higher risk of abnormal HDL-C level than the individuals with GG genotype among children and adolescents.
authors.affiliation: Department of Child, Adolescent and Women's Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.
authors.forename: Fang-hong
authors.initials: FH
authors.lastname: Liu
authors.affiliation: Department of Child, Adolescent and Women's Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.
authors.forename: Jjie-yun
authors.initials: JY
authors.lastname: Song
authors.affiliation: Department of Child, Adolescent and Women's Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Child, Adolescent and Women's Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.
authors.forename: Xiao-rui
authors.initials: XR
authors.lastname: Shang
authors.affiliation: Department of Child, Adolescent and Women's Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.
authors.forename: Xiang-rui
authors.initials: XR
authors.lastname: Meng
authors.affiliation: Department of Child, Adolescent and Women's Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.
authors.forename: Hai-jun
authors.initials: HJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; C497390:SREBF2 protein, human; D051782:Sterol Regulatory Element Binding Protein 2; D014280:Triglycerides