title: Physiological changes in blood pressure impact peripheral endothelial function during adolescence.
abstract: Reactive hyperemia index is a measure of endothelial function used to assess subclinical atherosclerosis. When evaluated in healthy adolescents, significant changes in endothelial function were correlated with advancing age, pubertal status, and blood pressure. Blood pressure was the principal contributor to reactive hyperemia index variability independent of age, lipid profile, body mass index, and/or pubertal status. Interpretation of this peripheral vascular marker should include age and maturational changes in paediatric patients.
authors.affiliation: 1Department of Endocrinology,Hospital for Sick Children,University of Toronto,Ontario,Canada.
authors.forename: Livia
authors.initials: L
authors.lastname: Deda
authors.affiliation: 1Department of Endocrinology,Hospital for Sick Children,University of Toronto,Ontario,Canada.
authors.forename: Etienne B
authors.initials: EB
authors.lastname: Sochett
authors.affiliation: 1Department of Endocrinology,Hospital for Sick Children,University of Toronto,Ontario,Canada.
authors.forename: Farid H
authors.initials: FH
authors.lastname: Mahmud
mesh_terms: D000293:Adolescent; D000067697:Adolescent Health; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D011627:Puberty / Q000502:physiology; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: reactive hyperemia index