title: Blood biochemistry, thyroid hormones, and oxidant/antioxidant status of guinea pigs challenged with sodium arsenite or arsenic trioxide.
abstract: The present experiment aimed to compare the two most commonly used compounds of arsenic (sodium arsenite and arsenic trioxide) for their effect on blood metabolites, thyroid hormones, and oxidant/antioxidant status in guinea pigs. Twenty-one adult guinea pigs were randomly divided into three equal groups. Animals in group T1 (control) were fed a basal diet, whereas 50 ppm arsenic was added in the basal diet either as sodium arsenite (T2) or arsenic trioxide (T3) and fed for 11 weeks. Serum aspartate aminotransferase and alanine aminotransferase activities were significantly increased along with a decrease in blood hemoglobin level in both the arsenic-administered groups. The level of erythrocytic antioxidants (catalase, superoxide dismutase, reduced glutathione, glutathione-S-transferase, and glutathione reductase) was decreased and lipid peroxidation was elevated upon arsenic exposure. Serum thyroid hormone levels were reduced and arsenic levels in tissues increased in both the arsenic-exposed groups, irrespective of the arsenic compound. Thus, sodium arsenite and arsenic trioxide exerted similar adverse effects on blood metabolic profile, antioxidant status, and thyroid hormones in guinea pigs.
authors.affiliation: Animal Nutrition Division, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243 122, India, mohanta.ranjan@gmail.com.
authors.forename: Ranjan Kumar
authors.initials: RK
authors.lastname: Mohanta
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Garg
authors.forename: Ram Sharan
authors.initials: RS
authors.lastname: Dass
authors.forename: Suvendu Kumar
authors.initials: SK
authors.lastname: Behera
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology*; D018053:Arsenites / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002374:Catalase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006168:Guinea Pigs; D006454:Hemoglobins / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D016877:Oxidants / Q000378:metabolism*; D010087:Oxides / Q000494:pharmacology*; D011897:Random Allocation; D017670:Sodium Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D000975:Antioxidants; D001152:Arsenicals; D018053:Arsenites; D001786:Blood Glucose; D001798:Blood Proteins; D006454:Hemoglobins; D016877:Oxidants; D010087:Oxides; D017670:Sodium Compounds; D013963:Thyroid Hormones; C017947:sodium arsenite; D002784:Cholesterol; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D000077237:Arsenic Trioxide