title: Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension.
abstract: This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension. A total of 162 obese and 162 nonobese men with hypertension were recruited in this study. Plasma angiotensinogen levels were measured by enzyme-linked immunosorbent assay. Fasting insulin (FINS) was evaluated by radioimmunoassay. Compared with nonobese patients, obese patients exhibited higher levels of angiotensinogen, FINS, and homeostasis model assessment index-insulin resistance (HOMA-IR) (P<.001 for all). Moreover, these indexes significantly increased in obese patients in the highest tertile of SUA when compared with those in the lowest tertile of SUA (P<.001, P=.002, P=.007, respectively). In the obese group, SUA levels were significantly related to angiotensinogen, FINS, and HOMA-IR, respectively. Furthermore, it was demonstrated that obesity × uric acid was an independent contributor to angiotensinogen (β=0.257, P<.001). In conclusion, elevated SUA is strongly related to angiotensinogen in an obesity-dependent manner in hypertension.
authors.affiliation: Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wuquan
authors.initials: W
authors.lastname: Deng
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology; D000328:Adult; D000808:Angiotensinogen / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference
chemical_list: D007328:Insulin; D000808:Angiotensinogen; D014527:Uric Acid