title: Chemogenesis of an antiangiogenic glycosaminoglycan.
abstract: In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches. This work highlights the potential for industrial scale production of a therapeutic anticancer glycosaminoglycan.
authors.affiliation: Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States.
authors.forename: Karthik
authors.initials: K
authors.lastname: Raman
authors.affiliation: Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.
authors.forename: Sailaja
authors.initials: S
authors.lastname: Arungundram
authors.affiliation: Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States ; Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States ; Interdepartmental Program in Neuroscience, University of Utah , Salt Lake City, Utah 84112, United States.
authors.forename: Balagurunathan
authors.initials: B
authors.lastname: Kuberan
keywords: Acharan sulfate; angiogenesis; heparan sulfate; heparin; synthesis