title: Associations between hsa-miR-603 polymorphism, lifestyle-related factors and colorectal cancer risk.
abstract: BACKGROUND
  Accumulated studies have suggested that single nucleotide polymorphisms (SNPs) in microRNAs are associated with risk of colorectal cancer (CRC).
  
  
  OBJECTIVE
  We tested our hypothesis that rs11014002 in hsa-miR-603 may be associated with CRC risk with a crosstalk of life-related factors.
  
  
  METHODS
  We conducted a case-control study which included 102 CRC patients and 204 matched cancer-free controls in Xiaoshan County.
  
  
  RESULTS
  We observed that subjects with rs11014002 CT/TT genotype had an increased susceptibility for CRC (CT vs. CC: odds ratio (OR)=2.352, 95% confidence interval (CI): 1.142-4.840, P=0.020; CT+TT vs. CC: OR=2.031, 95% CI: 1.063-3.883, P=0.032). After stratification by lifestyle-related factors, similar results were found among nonsmokers (CT vs. CC: OR=2.753, 95% CI: 1.085-6.983, P=0.033; CT+TT vs. CC: OR=2.971, 95% CI: 1.188-7.435, P=0.020) and non-alcohol drinkers (CT+TT vs. CC: OR=3.279, 95% CI: 1.071-10.033, P=0.037).
  
  
  CONCLUSIONS
  Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility.
authors.affiliation: Center for Disease Control and Prevention of Xiaoshan, Hangzhou, Zhejiang, China.
authors.forename: Fen-Juan
authors.initials: FJ
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Mao
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Jing
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Center for Disease Control and Prevention of Xiaoshan, Hangzhou, Zhejiang, China.
authors.forename: Long-Fang
authors.initials: LF
authors.lastname: Jiang
authors.affiliation: Center for Disease Control and Prevention of Xiaoshan, Hangzhou, Zhejiang, China.
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Guo
authors.affiliation: Center for Disease Control and Prevention of Xiaoshan, Hangzhou, Zhejiang, China.
authors.forename: Xiang-Jue
authors.initials: XJ
authors.lastname: Sun
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
authors.forename: Ming-Juan
authors.initials: MJ
authors.lastname: Jin
authors.affiliation: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008019:Life Style; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D035683:MicroRNAs
keywords: colorectal cancer; hsa-miR-603; polymorphism; susceptibility