title: [Toxicity research status of benzalkonium chloride on ocular surface].
abstract: Benzalkonium chloride (BAC) is the most commonly used preservative in ophthalmic preparations.So far large bodies of clinical and experimental studies have shown that use of topical drugs containing BAC can induce a series of ocular surface diseases, such as apoptosis.However, recently, some clinical studies have shown that ocular toxicity in patients treated with eye drops containing BAC has not apparent correlated with BAC.Some scholars consider that the limitations of the research lead people to recognize the BAC toxicity exaggeratedly.Here we summarize numerous clinical and experimental studies of BAC in the past few years, and focus on reviewing recent researches of the toxic effect of BAC on ocular surface.
authors.affiliation: Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Huang
authors.affiliation: Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Chen
authors.affiliation: Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China.
authors.forename: Yongxiong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. Email: zuguoliu@xmu.edu.cn.
authors.forename: Zuguo
authors.initials: Z
authors.lastname: Liu
mesh_terms: D017209:Apoptosis; D001548:Benzalkonium Compounds / Q000009:adverse effects*; D003228:Conjunctiva / Q000187:drug effects*; D005123:Eye / Q000187:drug effects; D006801:Humans; D009883:Ophthalmic Solutions / Q000009:adverse effects* / Q000737:chemistry; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D001548:Benzalkonium Compounds; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical