title: Bone scintigraphy in osteosarcoma: a single institution experience.
abstract: Bone scintigraphy is a well-established method to evaluate for metastatic disease in osteosarcoma. We identified a patient who had a negative (cold) bone scan at skeletal relapse and consequently reviewed the frequency of cold scans in osteosarcoma at our institution. No cold scans were identified at diagnosis, and only 1 patient had a cold scan at skeletal recurrence. No correlation was identified between clinical outcomes and bone scan features, other than identification of metastatic disease. Patients with skeletal recurrence were all symptomatic, thus we suggest that bone scintigraphy is not indicated in routine postchemotherapy surveillance for patients with osteosarcoma.
authors.affiliation: Departments of *Pediatrics ∥Radiology, The University of Texas Southwestern Medical Center †Children's Medical Center, Dallas, TX ‡Department of Pediatrics, The University of Colorado, Denver §Colorado Children's Hospital, Aurora, CO.
authors.forename: Jacquelyn M
authors.initials: JM
authors.lastname: Powers
authors.forename: Carrye
authors.initials: C
authors.lastname: Cost
authors.forename: Kevin
authors.initials: K
authors.lastname: Cederberg
authors.forename: David
authors.initials: D
authors.lastname: Leonard
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Leavey
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D011877:Radionuclide Imaging; D012189:Retrospective Studies