title: Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)-H bonds with aryl halides using a removable auxiliary.
abstract: A Pd(II)-catalyzed arylation of methylene C(sp(3))-H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China. bfshi@zju.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Yin
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhao
authors.forename: Sheng-Long
authors.initials: SL
authors.lastname: Fang
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Shi
mesh_terms: D000577:Amides / Q000737:chemistry; D001965:Bromides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D001965:Bromides; D007454:Iodides; D010165:Palladium; D002244:Carbon; D006859:Hydrogen