title: Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma.
abstract: BACKGROUND
  Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is highly accurate in diagnosing mediastinal lymphadenopathies of lung cancer and benign disorders. However, the utility of EBUS-TBNA in the diagnosis of mediastinal lymphomas is unclear. The aim of this study was to determine the diagnostic value of EBUS-TBNA in patients with suspected lymphoma.
  
  
  METHODS
  Sixty-eight patients with isolated mediastinal lymphadenopathy and suspected of lymphoma were included in the study. EBUS-TBNA was performed on outpatients under moderate sedation. The sensitivity, specificity, negative predictive value and diagnostic accuracy of EBUS-TBNA were calculated.
  
  
  RESULTS
  Sixty-four patients were diagnosed by EBUS-TBNA, but four patients with non-diagnostic EBUS-TBNA required surgical procedures. Thirty-five (51.5%) patients had sarcoidosis, six (8.8%) had reactive lymphadenopathy, nine (13.3%) had tuberculosis, one (1.5%) had squamous cell carcinoma, two (2.9%) had sarcoma and fifteen (22%) had lymphoma (follicular center cell, large B-cell primary, and Hodgkin lymphomas in three, two, and ten, respectively). Of the 15 lymphoma patients, thirteen were diagnosed by EBUS and two by thoracotomy and mediastinoscopy. The sensitivity, specificity, negative predictive value, and diagnostic accuracy of EBUS-TBNA for the diagnosis of lymphoma were calculated as 86.7%, 100%, 96.4%, and 97%, respectively.
  
  
  CONCLUSIONS
  EBUS-TBNA can be employed in the diagnosis of mediastinal lymphoma, instead of more invasive surgical procedures.
authors.affiliation: Department of Pulmonary Diseases, Ataturk Training and Research Hospital, Ankara, Turkey E-mail : asenturk1967@yahoo.com.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Senturk
authors.forename: Elif
authors.initials: E
authors.lastname: Babaoglu
authors.forename: Hatice
authors.initials: H
authors.lastname: Kilic
authors.forename: Habibe
authors.initials: H
authors.lastname: Hezer
authors.forename: Hayriye Tatli
authors.initials: HT
authors.lastname: Dogan
authors.forename: Hatice Canan
authors.initials: HC
authors.lastname: Hasanoglu
authors.forename: Semra
authors.initials: S
authors.lastname: Bilaceroglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods; D001980:Bronchi / Q000473:pathology*; D001999:Bronchoscopy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008481:Mediastinoscopy; D008875:Middle Aged; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000175:diagnosis / Q000473:pathology; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult