title: The Effects of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.
abstract: BACKGROUND
  A standardized rose-hip powder produced from the seeds and husks of fruit from a subtype of Rosa canina has been reported to inhibit leukocyte functions that cause cell injury in osteoarthritis.
  
  
  OBJECTIVE
  The aim of this study was to assess the impact of standardized rose-hip powder on mobility of the hip and knee joints, activities of daily living, quality of life, and pain in patients with osteoarthritis.
  
  
  METHODS
  Patients with a diagnosis of osteoarthritis of either the hip or knee, verified on radiography, participated in this randomized, placebo-controlled, double-blind study. Half of the patients were given five 0.5-g capsules of standardized rose-hip powder twice daily for 4 months, and the other half received identical placebo capsules twice daily for the same period. Mobility of the hip or knee was measured in both groups after the initial screening and again after 4 months of therapy.
  
  
  RESULTS
  One hundred patients (65 women, 35 men; mean [SD] age, 65.2 [11.1] years) were divided into 2 treatment groups of 50 patients each. Hip joint mobility improved significantly in the treatment group compared with the placebo group (P = 0.033). Similarly, pain decreased significantly in the treatment group compared with the placebo group (P = 0.035). Two patients (4%) from each group withdrew during the early stages of the trial for reasons not related to treatment.
  
  
  CONCLUSIONS
  In this study population, standardized rose-hip powder reduced symptoms of osteoarthritis, as 64.6% of patients reported at least some reduction of pain while receiving treatment. Standardized rose-hip powder may improve hip flexion and reduce pain in patients with osteoarthritis.
authors.affiliation: Department of Orthopaedic Surgery, Vestfold Central Hospital, Tønsberg, Norway.
authors.forename: Odd
authors.initials: O
authors.lastname: Warholm
authors.affiliation: Department of Orthopaedic Surgery, Vestfold Central Hospital, Tønsberg, Norway.
authors.forename: Sigrun
authors.initials: S
authors.lastname: Skaar
authors.affiliation: Department of Orthopaedic Surgery, Vestfold Central Hospital, Tønsberg, Norway.
authors.forename: Ewa
authors.initials: E
authors.lastname: Hedman
authors.affiliation: Department of Orthopaedic Surgery, Vestfold Central Hospital, Tønsberg, Norway.
authors.forename: Hanna Maria
authors.initials: HM
authors.lastname: Mølmen
authors.affiliation: Department of Orthopaedic Surgery, Vestfold Central Hospital, Tønsberg, Norway.
authors.forename: Liv
authors.initials: L
authors.lastname: Eik
keywords: Rosa canina; osteoarthritis; pain; rose-hip powder; stiffness