title: An increased risk of ovarian cancer associated with polymorphism in BRCC5 gene in Caucasian populations.
abstract: Several reports on the association between the BRCC5 gene polymorphism and ovarian cancer risk have been published recently, but the estimates of the risk vary widely. We thus performed a meta-analysis in an effort to determine the association. To identify the eligible studies, we searched the PubMed, Embase, and CNKI databases, and reviewed all original studies retrieved as well as their citations. The risk of ovarian cancer was estimated using odds ratio (OR) and its 95 % confidence interval (CI). Meta-analysis of seven comparisons revealed an obvious rise in the risk of ovarian cancer under the CC vs. GG contrast model (OR = 1.52, 95 % CI = 1.07-2.16, P OR = 0.020). A similar increase was also indicated in the CC vs. GC + GG model (OR = 2.10, 95 % CI = 1.51-2.93, P OR < 0.001). Our meta-analysis indicates that the BRCC5 polymorphism may be a candidate modifier of ovarian cancer risk in Caucasians.
authors.affiliation: Renmin Hospital, Department of Obstetrics & Gynecology, Wuhan University, Wuhan, 430060, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Liang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Ruo-Yu
authors.initials: RY
authors.lastname: Luo
authors.forename: Fu-Jin
authors.initials: FJ
authors.lastname: Shen
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D051135:Rad51 Recombinase / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C495153:RAD51 protein, human; D051135:Rad51 Recombinase