title: Analysis of NFATc1-centered transcription factor regulatory networks in osteoclast formation.
abstract: Osteoclasts are bone-resorbing cells that differentiate from the macrophage/monocyte lineage. The master transcription factor NFATc1 has a central role in the process of this differentiation. Thus, it is important to understand the NFATc1-centered transcription factor regulatory networks (TFRNs) in terms of the mechanisms of NFATc1 expression and activation as well as the gene expression regulated by NFATc1. The Genome Network Project has provided a unique opportunity for the analysis of NFATc1-centered TFRNs in osteoclasts. Here we introduce a report on the application of the methods established by the project for osteoclast biology and a summarization of the results obtained in this project thus far.
authors.affiliation: Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8510, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinohara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation; D002469:Cell Separation / Q000379:methods; D002478:Cells, Cultured; D005260:Female; D053263:Gene Regulatory Networks; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000166:cytology* / Q000378:metabolism; D050778:NFATC Transcription Factors / Q000235:genetics / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology* / Q000378:metabolism; D060066:Protein Interaction Maps; D059467:Transcriptome
chemical_list: D050778:NFATC Transcription Factors