title: 40 GHz RF biosensor based on microwave coplanar waveguide transmission line for cancer cells (HepG2) dielectric characterization.
abstract: This paper presents a 40-GHz RF biosensor that involves using a microwave coplanar waveguide (CPW) transmission line for the dielectric characterization of cancer cells (Hepatoma G2, HepG2). In the past, conventional resonator-based biosensors were designed to operate at a specific resonant peak; however, the dielectric sensitivity of the cells was restricted to a narrow bandwidth. To provide a very wide bandwidth (1-40 GHz), biosensors were based on a microwave CPW transmission line. The proposed biosensor can rapidly measure two frequency-dependent cell-based dielectric parameters of HepG2 cells, microwave attenuation (α(f)cell) and the dielectric constant (εr(f)cell), while removing the microwave parasitic effects (including the cultured medium and substrate materials). The proposed biosensor can be applied in postoperative cancer diagnosis.
authors.affiliation: Department of Photonics, National Cheng Kung University, No. 1, University Road, Tainan City, 701, Taiwan.
authors.forename: Yu-Fu
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of Computer and Communication, Kun Shan University, No. 195, Kunda Road, YongKang District, Tainan City, 710-03, Taiwan. Electronic address: hwwu@mail.ksu.edu.tw.
authors.forename: Hung-Wei
authors.initials: HW
authors.lastname: Wu
authors.affiliation: Department of Nutrition, I-Shou University, No. 8, Yida Road, Jiaosu Village Yanchao District, Kaohsiung City, 82445, Taiwan.
authors.forename: Yong-Han
authors.initials: YH
authors.lastname: Hong
authors.affiliation: Department of Photonics, National Cheng Kung University, No. 1, University Road, Tainan City, 701, Taiwan. Electronic address: hylee@ee.ncku.edu.tw.
authors.forename: Hsin-Ying
authors.initials: HY
authors.lastname: Lee
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D049109:Cell Proliferation; D004560:Electricity; D004867:Equipment Design; D056945:Hep G2 Cells / Q000166:cytology / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis; D008872:Microwaves
keywords: Biosensor; Coplanar waveguide (CPW); Dielectric characterization; HepG2 cells; Microwave