title: PTPRT regulates high-fat diet-induced obesity and insulin resistance.
abstract: Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity.
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Xiujing
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Anthony
authors.initials: A
authors.lastname: Scott
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Doerner
authors.affiliation: Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Satake
authors.affiliation: Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, United States of America.
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Croniger
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America; Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America.
authors.forename: Zhenghe
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D001786:Blood Glucose; D059305:Diet, High-Fat; D004041:Dietary Fats; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000473:pathology; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2 / Q000235:genetics*; D050796:STAT3 Transcription Factor / Q000096:biosynthesis* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; C516866:Ptprt protein, mouse; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2