title: Mean platelet volume and platelet distribution width can be related to bone mineralization.
abstract: Platelets functions are related to bone resorption and formation. The present study aimed at studying the association between platelet function and bone mineralization. We showed that mean platelet volume (MPV) and platelet distribution width (PDW) levels in osteoporosis patients increased. The study also showed that PDW and age independently associated with bone mineralization.
  
  
  BACKGROUND
  MPV and PDW are widely used for assessing platelet function. Recently, authors argued that platelet function has an important role in bone mineralization. However, only one study has investigated the relationship between MPV and osteoporosis. We aimed to study the levels of MPV and PDW in postmenopausal osteoporosis.
  
  
  METHODS
  We investigated 320 bone mineral density (BMD) measurements between the years 2012 and 2013 retrospectively in our clinic. Eighty patients whom chronic diseases are absent and all laboratory findings are complete enrolled in this study. Patients were divided in three groups as an osteoporosis, osteopenia, and normal BMD group. MPV and PDW levels were investigated in these groups. We performed correlation test and linear regression analysis to determine whether there is a relationship between platelet function markers and BMD measurements.
  
  
  RESULTS
  Eighty patients were divided as an osteoporosis, osteopenia, and normal BMD group. MPV levels and PDW levels in the osteoporosis group were lower than the normal BMD group. PDW was positively correlated with femur total T (FTT) score and lumbar 1-4T (L1-4T) scores. Linear regression analysis showed that age and PDW were independently related to FTT and LTT scores.
  
  
  CONCLUSIONS
  Platelet functions are related to the bone mineralization. PDW and MPV have a significant role in the development of postmenopausal osteoporosis.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, draylayavuz@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Akbal
authors.forename: F
authors.initials: F
authors.lastname: Gökmen
authors.forename: M
authors.initials: M
authors.lastname: Gencer
authors.forename: B S
authors.initials: BS
authors.lastname: Inceer
authors.forename: E
authors.initials: E
authors.lastname: Kömürcü
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000097:blood; D048429:Cell Size; D005260:Female; D006801:Humans; D063847:Mean Platelet Volume; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D010979:Platelet Function Tests / Q000379:methods; D012189:Retrospective Studies