title: The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis.
abstract: The association between the rs498872 single nucleotide polymorphism (SNP) and glioma risk has been studied, but these studies have yielded conflicting results. In order to explore this association, we performed a meta-analysis. A comprehensive literature search was performed using PubMed and EMBASE database, with the last search up to August 23, 2013. Six articles including 10 case-control studies in English with 18 002 controls and 8434 cases were eligible for the meta-analysis. Subgroup analyses were conducted by source of controls and ethnicity. The combined results showed that rs498872 polymorphism was significantly associated with glioma risks (TT vs CC: OR = 1.337, 95% CI = 1.222-1.462; TC vs CC: OR = 1.173, 95% CI = 1.081-1.272; dominant model: OR = 1.199, 95% CI = 1.101-1.306; recessive model: OR = 1.237, 95% CI = 1.135-1.347; additive model: OR = 1.156, 95% CI = 1.085-1.232). Moreover, there was increased cancer risk in all genetic models after stratification of the SNP data by the source of controls and ethnicity, and no evidence of publication bias was produced. Our meta-analysis suggested that rs498872 polymorphism was associated with increased risk of glioma. However, additional studies exploring the combined effects of rs498872 polymorphisms in Asian population should be investigated.
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Xingchun
authors.initials: X
authors.lastname: Gao
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Mi
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Aili
authors.initials: A
authors.lastname: Yan
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Baoyong
authors.initials: B
authors.lastname: Sha
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Na
authors.initials: N
authors.lastname: Guo
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Fengliang
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Institute of Basic Medical Science, Xi'an Medical University, Xi'an, China.
authors.forename: Xingchun
authors.initials: X
authors.lastname: Gou
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; C487973:PHLDB1 protein, human
keywords: gliomaPHLDB1polymorphism; meta-analysis