title: Diabetes mellitus increases risk for colorectal adenomas in younger patients.
abstract: OBJECTIVE
  To determine if diabetes mellitus (DM) is associated with increased risk of colorectal adenomas in younger subjects.
  
  
  METHODS
  This was a retrospective cohort study of 375 patients undergoing index colonoscopy at a single tertiary care center in the United States. Three cohorts of patients matched for exam date and gender were compared: (1) ages 40-49 years with DM; (2) ages 40-49 years without DM; and (3) ages 50-59 years without DM. Data collected included demographics, co-morbidities, colonoscopy and pathology results. Adenoma detection rates (ADR) were calculated and compared. Conditional logistic regression analysis was performed to determine the association between each cohort and ADR.
  
  
  RESULTS
  One hundred and twenty-five patients ages 40-49 with DM met study eligibility criteria. Patients in the other two cohorts were randomly selected, matching for date of exam and gender. ADR was 14.4% in those ages 40-49 years without DM, 30.4% in those ages 40-49 years with DM, and 32.0% in those ages 50-59 years without DM. Compared to those ages 40-49 years without DM, ADR was higher in those ages 40-49 years with DM (OR = 3.1; 95%CI: 1.5-6.4; P = 0.002) and those ages 50-59 years without DM (OR = 2.9; 95%CI: 1.5-5.6; P = 0.002). There was no difference between the ADR in those ages 40-49 years with DM and those ages 50-59 years without DM (P = 0.83).
  
  
  CONCLUSIONS
  DM was associated with higher risk of colorectal adenomas in patients ages 40-49 years. These subjects harbored as many adenomas as those at the standard screening age of 50-59 years without DM.
authors.affiliation: Hongha T Vu, Nneka Ufere, Yan Yan, Jean S Wang, Dayna S Early, Jill E Elwing, Division of Gastroenterology, Washington University, St. Louis, MO 63110, United States.
authors.forename: Hongha T
authors.initials: HT
authors.lastname: Vu
authors.affiliation: Hongha T Vu, Nneka Ufere, Yan Yan, Jean S Wang, Dayna S Early, Jill E Elwing, Division of Gastroenterology, Washington University, St. Louis, MO 63110, United States.
authors.forename: Nneka
authors.initials: N
authors.lastname: Ufere
authors.affiliation: Hongha T Vu, Nneka Ufere, Yan Yan, Jean S Wang, Dayna S Early, Jill E Elwing, Division of Gastroenterology, Washington University, St. Louis, MO 63110, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Hongha T Vu, Nneka Ufere, Yan Yan, Jean S Wang, Dayna S Early, Jill E Elwing, Division of Gastroenterology, Washington University, St. Louis, MO 63110, United States.
authors.forename: Jean S
authors.initials: JS
authors.lastname: Wang
authors.affiliation: Hongha T Vu, Nneka Ufere, Yan Yan, Jean S Wang, Dayna S Early, Jill E Elwing, Division of Gastroenterology, Washington University, St. Louis, MO 63110, United States.
authors.forename: Dayna S
authors.initials: DS
authors.lastname: Early
authors.affiliation: Hongha T Vu, Nneka Ufere, Yan Yan, Jean S Wang, Dayna S Early, Jill E Elwing, Division of Gastroenterology, Washington University, St. Louis, MO 63110, United States.
authors.forename: Jill E
authors.initials: JE
authors.lastname: Elwing
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D003111:Colonic Polyps / Q000175:diagnosis / Q000453:epidemiology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers; D014861:Washington / Q000453:epidemiology
keywords: Adenoma; Colonoscopy; Colorectal cancer; Diabetes mellitus; Risk factor