title: Immunomodulation of nanoparticles in nanomedicine applications.
abstract: Nanoparticles (NPs) have promising applications in medicine. Immune system is an important protective system to defend organisms from non-self matters. NPs interact with the immune system and modulate its function, leading to immunosuppression or immunostimulation. These modulating effects may bring benefits or danger. Compositions, sizes, and surface chemistry, and so forth, affect these immunomodulations. Here we give an overview of the relationship between the physicochemical properties of NPs, which are candidates to be applied in medicine, and their immunomodulation properties.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiao
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Liwen
authors.initials: L
authors.lastname: Li
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA ; Department of Materials Science & Engineering, University of Washington, Seattle, WA 98125, USA.
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Mu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D006801:Humans; D007114:Immunization; D056747:Immunomodulation / Q000187:drug effects*; D007165:Immunosuppression Therapy; D050997:Nanomedicine; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*