title: Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory?
abstract: Associations of various histotypes in appendiceal neoplasms may help elucidate the histogenesis of such uncommon tumors. We present the fourth published case of Goblet Cell Carcinoid (GCC) associated with mucinous adenocarcinoma of the appendix. This association has been described only for GCC and not for classic appendix carcinoids which are thought to originate from neuroendocrine-committed cells. The GCC-mucinous association adds more towards the theory of a pluripotent intestinal stem cell with amphicrine possibilities of differentiation.
authors.affiliation: Department of Surgery, and Department of Histopathology, George Eliot Hospital, Nuneaton, United Kingdom. ggravante@hotmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Gravante
authors.forename: S
authors.initials: S
authors.lastname: Yahia
authors.forename: K
authors.initials: K
authors.lastname: Gopalakrishnan
authors.forename: G
authors.initials: G
authors.lastname: Mathew
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D001063:Appendiceal Neoplasms / Q000473:pathology*; D002276:Carcinoid Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology*