title: Uncommon opportunistic yeast bloodstream infections from Qatar.
abstract: Eleven uncommon yeast species that are associated with high mortality rates irrespective of antifungal therapy were isolated from 17/187 (201 episodes) pediatric and elderly patients with fungemia from Qatar. The samples were taken over a 6-year period (January 2004-December 2010). Isolated species included Kluyveromyces marxianus, Lodderomyces elongisporus, Lindnera fabianii, Candida dubliniensis, Meyerozyma guilliermondii, Candida intermedia, Pichia kudriavzevii, Yarrowia lipolytica, Clavispora lusitaniae, Candida pararugosa, and Wickerhamomyces anomalus. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry provided correct identifications compared with molecular analysis testing of the same isolates. Low minimal inhibitory concentrations were found when isavuconazole and voriconazole were used for all uncommon yeast species evaluated in this study. Resistance to antifungal drugs was low and remained restricted to a few species.
authors.affiliation: Mycology Unit, Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar stajaldeen@hmc.org.qa.
authors.forename: Saad J
authors.initials: SJ
authors.lastname: Taj-Aldeen
authors.affiliation: Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar Weill-Cornel Medical College, Qatar.
authors.forename: Atqah
authors.initials: A
authors.lastname: AbdulWahab
authors.affiliation: CBS Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: Anna
authors.initials: A
authors.lastname: Kolecka
authors.affiliation: Mycology Unit, Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Anand
authors.initials: A
authors.lastname: Deshmukh
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
authors.affiliation: CBS Fungal Biodiversity Centre, Utrecht, The Netherlands Department of Internal Medicine and Infectious Diseases, University Medical Center, Utrecht, The Netherlands Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Institute of Dermatology and Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai Institute of Microbiology, Chinese Academy of Science, Beijing, People's Republic of China.
authors.forename: Teun
authors.initials: T
authors.lastname: Boekhout
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D011780:Qatar / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D062606:Tertiary Care Centers; D016896:Treatment Outcome; D015003:Yeasts / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents
keywords: MALDI-TOF MS; antifungal susceptibility; bloodstream infections; outcome; risk factors; uncommon yeasts