title: NK₃ receptor agonism reinstates temporal order memory in the hemiparkinsonian rat.
abstract: Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged rat and to alleviate scopolamine-induced impairment, the present study aimed to assess possible promnestic effects of senktide in the hemiparkinsonian rat model. Animals received unilateral 6-ODHA microinjections into the medial forebrain bundle. Two weeks later, they were randomly assigned to treatment with vehicle, 0.2, or 0.4 mg/kg senktide. Temporal order memory and place recognition tests were conducted, locomotor activity and turning behavior were assessed in the open field and anxiety-related behavior was measured in the light-dark box. Treatments were administered 30 min prior to behavioral testing with an interval of seven days between tests. The animals treated with 0.2 mg/kg senktide exhibited temporal order memory, unlike the vehicle-treated group. No significant treatment effects were found in the open field and light-dark box. Administration of 0.2 mg/kg senktide may influence the prefrontal cortex and hippocampus, leading to compensations for deficits in memory for temporal order.
authors.affiliation: Center for Behavioral Neuroscience, University of Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany. Electronic address: owenchao@gmail.com.
authors.forename: Owen Y
authors.initials: OY
authors.lastname: Chao
authors.affiliation: Center for Behavioral Neuroscience, University of Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
authors.forename: An-Li
authors.initials: AL
authors.lastname: Wang
authors.affiliation: Clinic of Nuclear Medicine, University Hospital Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Nikolaus
authors.affiliation: Center for Behavioral Neuroscience, University of Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
authors.forename: Maria A
authors.initials: MA
authors.lastname: de Souza Silva
mesh_terms: D000818:Animals; D008297:Male; D008474:Medial Forebrain Bundle; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D009068:Movement; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000494:pharmacology*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D010446:Peptide Fragments / Q000494:pharmacology*; D011897:Random Allocation; D017208:Rats, Wistar; D018042:Receptors, Neurokinin-3 / Q000819:agonists* / Q000378:metabolism; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D013998:Time Perception / Q000187:drug effects* / Q000502:physiology
chemical_list: D018697:Nootropic Agents; D010446:Peptide Fragments; D018042:Receptors, Neurokinin-3; C054724:senktide; D013373:Substance P; D016627:Oxidopamine
keywords: 6-OHDA; NK(3) receptor; Parkinson's disease; Senktide; Temporal order memory