title: Ethoexperimental analysis of the impact of chlordiazepoxide (CDP) on social interactions in three strains of mice.
abstract: Categories of male C57BL/10, BALB/c and Swiss mice were injected s.c. with saline or 2.5, 5 or 10 mg/kg of CDP in saline 15 min prior to encounters with peripherally anosmic Swiss male 'standard opponents'. The 10-min encounters were videotaped and subsequently analysed using a microprocessor for the times allocated to 11 broad ethological categories of behaviour. The animal's genotype had a profound effect on its response to CDP, effects being evident on attack, threat, avoidance-flee, defensive-submissive behaviour, social investigation, non-social investigation, digging and exploration-from-a-distance. Only body care and immobility showed no clear strain effect. A dose-effect of CDP was only evident on defense-submission - indeed the drug progressively increased the incidence of this behaviour in all strains.
authors.affiliation: Biological Sciences, University of Wales at Swansea, Swansea, UK.
authors.forename: B
authors.initials: B
authors.lastname: Everill
authors.affiliation: Biological Sciences, University of Wales at Swansea, Swansea, UK.
authors.forename: P F
authors.initials: PF
authors.lastname: Brain
authors.affiliation: Jurusan Biologi, FMIPA-ITB, Bandung, Indonesia.
authors.forename: A
authors.initials: A
authors.lastname: Rustana
authors.affiliation: Department of Pharmacology, Duphar BV, Weesp, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Mos
authors.affiliation: Department of Pharmacology, Duphar BV, Weesp, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Olivier