title: Dietary supplementation with long chain polyunsaturated fatty acids in pregnant guinea pigs has sex-dependent effects on growth and bone outcomes in offspring.
abstract: Long chain PUFA enhance bone mass in non-pregnant mammals. We examined the effects of arachidonic (AA; 20:4n-6) and docosahexaenoic (DHA; 22:6n-3) acid on bone mass of mothers and neonates. Guinea pig sows (n=15) were fed control, DHA or AA+DHA diets from mating to weaning. Measurements included: osteocalcin (OC), deoxypyridinoline (DPD), areal bone mineral density (aBMD) in sows and neonates; and volumetric density (vBMD) in neonates. Only vertebral aBMD and OC:DPD ratio declined during reproduction and only DHA reduced OC:DPD. Male pup weight was reduced by DHA and female weight elevated by AA+DHA. Whole body and femur aBMD were reduced by DHA and AA+DHA; whereas tibia vBMD was reduced by DHA in males. Female whole body, tibia and vertebrae aBMD plus tibia vBMD were elevated by AA+DHA; and DHA elevated whole body, tibia and vertebrae aBMD. Dietary AA+DHA and DHA elicit sex-dependent effects on neonatal bone, with minimal impact on mothers.
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, Ste. Anne-de-Bellevue, Québec H9 X3V9, Canada.
authors.forename: Z
authors.initials: Z
authors.lastname: Yin
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, Ste. Anne-de-Bellevue, Québec H9 X3V9, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Agellon
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, Ste. Anne-de-Bellevue, Québec H9 X3V9, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Lavery
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, Ste. Anne-de-Bellevue, Québec H9 X3V9, Canada. Electronic address: hope.weiler@mcgill.ca.
authors.forename: H
authors.initials: H
authors.lastname: Weiler
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D016718:Arachidonic Acid / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D005260:Female; D005269:Femur / Q000187:drug effects* / Q000254:growth & development; D005333:Fetus; D006168:Guinea Pigs; D008297:Male; D015675:Osteocalcin / Q000378:metabolism; D011247:Pregnancy; D012098:Reproduction; D012737:Sex Factors; D013131:Spine / Q000187:drug effects* / Q000254:growth & development; D013977:Tibia / Q000187:drug effects* / Q000254:growth & development; D014886:Weaning
chemical_list: D000596:Amino Acids; D015675:Osteocalcin; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; C036020:deoxypyridinoline
keywords: Bone mass; Guinea pig; Long chain PUFA; Maternal; Offspring