title: Genome and transcriptome of the porcine whipworm Trichuris suis.
abstract: Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ∼140-fold coverage of adult male and female T. suis and ∼80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Jex
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Nejsum
authors.affiliation: 1] Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia. [2] Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
authors.forename: Erich M
authors.initials: EM
authors.lastname: Schwarz
authors.affiliation: BGI-Shenzhen, Shenzen, China.
authors.forename: Li
authors.initials: L
authors.lastname: Hu
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Young
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Ross S
authors.initials: RS
authors.lastname: Hall
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Pasi K
authors.initials: PK
authors.lastname: Korhonen
authors.affiliation: BGI-Shenzhen, Shenzen, China.
authors.forename: Shengguang
authors.initials: S
authors.lastname: Liao
authors.affiliation: University of Copenhagen, Copenhagen, Denmark.
authors.forename: Stig
authors.initials: S
authors.lastname: Thamsborg
authors.affiliation: BGI-Shenzhen, Shenzen, China.
authors.forename: Jinquan
authors.initials: J
authors.lastname: Xia
authors.affiliation: BGI-Shenzhen, Shenzen, China.
authors.forename: Pengwei
authors.initials: P
authors.lastname: Xu
authors.affiliation: BGI-Shenzhen, Shenzen, China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Wang
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Jean-Pierre Y
authors.initials: JP
authors.lastname: Scheerlinck
authors.affiliation: Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland, Australia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofmann
authors.affiliation: 1] Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA. [2] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Sternberg
authors.affiliation: 1] BGI-Shenzhen, Shenzen, China. [2] Department of Biology, University of Copenhagen, Copenhagen, Denmark. [3] Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia. [4] Macau University of Science and Technology, Taipa, Macau, China. [5] Department of Medicine, University of Hong Kong, Hong Kong.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
mesh_terms: D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D049751:Genome, Helminth; D059014:High-Throughput Nucleotide Sequencing; D006790:Host-Parasite Interactions / Q000235:genetics*; D006801:Humans; D008297:Male; D013552:Swine / Q000235:genetics / Q000469:parasitology*; D014257:Trichuriasis / Q000235:genetics* / Q000469:parasitology; D014258:Trichuris / Q000235:genetics*