title: Oxidation of hydrogen sulfide by human liver mitochondria.
abstract: Hydrogen sulfide (H2S) is the third gasotransmitter discovered. Sulfide shares with the two others (NO and CO) the same inhibiting properties towards mitochondrial respiration. However, in contrast with NO or CO, sulfide at concentrations lower than the toxic (μM) level is an hydrogen donor and a substrate for mitochondrial respiration. This is due to the activity of a sulfide quinone reductase found in a large majority of mitochondria. An ongoing study of the metabolic state of liver in obese patients allowed us to evaluate the sulfide oxidation capacity with twelve preparations of human liver mitochondria. The results indicate relatively high rates of sulfide oxidation with a large variability between individuals. These observations made with isolated mitochondria appear in agreement with the main characteristics of sulfide oxidation as established before with the help of cellular models.
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France; Service de chirurgie digestive et métabolique, APHP, Hôpitaux universitaires de Seine Saint Denis Hôpital Jean Verdier, 93143 Bondy Cedex, France; Université Paris 13, Bobigny, France.
authors.forename: Nada
authors.initials: N
authors.lastname: Helmy
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.
authors.forename: Carina
authors.initials: C
authors.lastname: Prip-Buus
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France; Service de chirurgie digestive et métabolique, APHP, Hôpitaux universitaires de Seine Saint Denis Hôpital Jean Verdier, 93143 Bondy Cedex, France; Université Paris 13, Bobigny, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Vons
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Lenoir
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.
authors.forename: Abbas
authors.initials: A
authors.lastname: Abou-Hamdan
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.
authors.forename: Hala
authors.initials: H
authors.lastname: Guedouari-Bounihi
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Lombès
authors.affiliation: Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France. Electronic address: frederic.bouillaud@inserm.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bouillaud
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D006862:Hydrogen Sulfide
keywords: Bioenergetics; Blood pressure; Liver; Mitochondria; Obesity; Oxygen consumption; Respiration; Sulfide