title: Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericum perforatum extract on induced oral mucositis in golden hamsters.
abstract: Oral mucositis is a common and irritating complication of chemotherapy and radiotherapy for malignancies. Current treatments have failed to achieve complete remission of this complication. The St. John's wort plant (Hypericum perforatum) has long been known for its anti-inflammatory and antibacterial effects. The current study was designed to investigate the therapeutic efficacy of the topical and systemic administration of H. perforatum extract on oral mucositis. Oral mucositis was induced in 72 male golden hamsters by administration of 5-fluorouracil (60mg/kg), on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, H. perforatum extract topical gel 10%, oral H. perforatum extract (300mg/kg), and gel base groups were treated and then compared with a control group. Weights and blood samples were evaluated, biopsies from buccal lesions were examined histopathologically, and tissue malondialdehyde (MDA) was measured. Both of the H. perforatum extract treatment groups saw a significant relief in oral mucositis compared to the control and base gel groups; the systemic form was superior to the topical form. H. perforatum extract, administered orally or topically, expedited the healing of chemotherapy-induced oral mucositis in hamsters.
authors.affiliation: Stem Cell and Transgenic Technology Research Centre and Pharmacology Department, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Tanideh
authors.affiliation: Students' Research Committee, School of Dentistry, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Namazi
authors.affiliation: Oral and Dental Health Care Research Center and Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Andisheh Tadbir
authors.affiliation: Oral Medicine Department, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: hooman.ebrahimi@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Ebrahimi
authors.affiliation: Laboratory Animal Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: O
authors.initials: O
authors.lastname: Koohi-Hosseinabadi
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity; D005472:Fluorouracil / Q000633:toxicity; D020902:Hypericum; D008297:Male; D008647:Mesocricetus; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D013280:Stomatitis / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D010936:Plant Extracts; D005472:Fluorouracil
keywords: Hypericum perforatum; animal model; chemotherapy; oral mucositis