title: Gastrointestinal stromal tumor: analysis of outcome and correlation with c-kit status in Indian population.
abstract: OBJECTIVE
  The aim of the present study is to analyse the outcome and genotypic pattern of metastatic GIST patients which is largely unknown in India.
  
  
  METHODS
  The present study was a retrospective analysis of 24 patients of metastatic GIST. The case records were analysed for clinical profile, treatment response and prognostic factors. The archival samples were retrieved for c-kit mutation analysis in all but 5 patients for mutation analysis.
  
  
  RESULTS
  The median age of the study population was 56 years. At a median follow up of 29 months, the PFS was 45% at 2 years. Activating c-kit mutations were detected in 10 cases (52.6%). 80% of the mutations were located in Exon 11.
  
  
  CONCLUSIONS
  The outcome of metastatic GIST patients has definitely improved from a virtually incurable state to a disease where median OS has reached 60 months. The genotype of Indian patients with GIST may be different from the western population which needs to be confirmed in a larger study.
authors.affiliation: Medical and Pediatric Oncologist, Caritas Cancer Institute, Kottayam, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Cyriac
authors.forename: R
authors.initials: R
authors.lastname: Rajendranath
authors.forename: T G
authors.initials: TG
authors.lastname: Sagar
mesh_terms: D000328:Adult; D000368:Aged; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000556:secondary; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D019009:Proto-Oncogene Proteins c-kit