title: Relationship between fatty liver disease and intracranial main artery stenosis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the relationship between fatty liver disease (FLD) and cerebrovascular disease.
  
  
  METHODS
  We conducted a cross-sectional study of 76 consecutive healthy subjects who participated in a two-day hospitalized health checkup program. The maximal intima-media thickness (IMT) of the common carotid artery and bifurcation of the carotid artery as well as the plaque score (PS) were evaluated on carotid artery ultrasonography. Fluid attenuated inversion recovery brain MRI was used to determine the presence of asymptomatic cerebral lesions and periventricular hyperintensity. Brain MR angiography was used to evaluate the degree of intracranial main artery stenosis (ICAS). FLD was diagnosed based on the ultrasonographic pattern.
  
  
  RESULTS
  The PS and IMT did not differ between the FLD (n=24) and non-FLD (n=52) groups. There was a tendency toward a higher percentage of multiple lacunar lesions in the non-FLD group than in the FLD group. ICAS was significantly more frequent in subjects in the FLD group than those in the non-FLD group (25.0% vs. 5.8%). A logistic regression analysis revealed that age and FLD were significant determinants of ICAS.
  
  
  CONCLUSIONS
  Our study findings suggest a significant association between ICAS and FLD.
authors.affiliation: Stroke Division, Department of Neurology, Dokkyo Medical University, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Asakawa
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Takekawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishii
authors.forename: Masami
authors.initials: M
authors.lastname: Ohrui
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000209:etiology; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged