title: A retrospective clinicopathological study of 131 cases with endometrial cancers--is it possible to define the role of retroperitoneal lymphadenectomy in low-resource settings?
abstract: OBJECTIVE
  The study objectives were evaluation of clinicopathological characteristics, correlations between the preoperative and postoperative tumor grades, and their implications on lymph node metastasis.
  
  
  METHODS
  We conducted a retrospective descriptive study of 131 cases of endometrial cancer examined and treated at a tertiary regional cancer institute between the years 2003 and 2009. We reviewed the oncology database as well as the clinical records and surgico-pathological registry of all these patients. Statistical Methods Used: All the summary measure computation and Chi-square test for comparing more than one proportion was done in spreadsheet (Excel).
  
  
  RESULTS
  The multiparity association with endometrial cancer was commonly seen 113/131 (86.2%). Twelve (9.7%) patients preoperatively diagnosed as Grade 1 tumors upgraded to Grade 3 changes in postoperative specimens and six of these 12 patients (50%) had lymph node metastasis. A total of 14/131 (10.6%) cases had lymph nodes metastasis.
  
  
  CONCLUSIONS
  There is a poor correlation between the preoperative and the postoperative tumor grades. Routine pelvic lymphadenectomy may be a valuable method in low-risk cases and para-aortic lymphadenectomy may be limited to high-risk endometrial cancers.
authors.affiliation: Department of Gynecologic Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India.
authors.forename: P S
authors.initials: PS
authors.lastname: Rathod
authors.forename: P V
authors.initials: PV
authors.lastname: Reddihalli
authors.forename: S
authors.initials: S
authors.lastname: Krishnappa
authors.forename: U K
authors.initials: UK
authors.lastname: Devi
authors.forename: U D
authors.initials: UD
authors.lastname: Bafna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000191:economics / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006295:Health Resources / Q000191:economics*; D006801:Humans; D007044:Hysterectomy / Q000191:economics*; D008197:Lymph Node Excision / Q000191:economics*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000191:economics / Q000556:secondary / Q000601:surgery*; D012189:Retrospective Studies