title: An uncommon case of Marine-Lenhart syndrome.
abstract: The term Marine-Lenhart syndrome describes the association between Graves' disease and autonomously functioning thyroid nodules (AFTN), such as toxic adenoma or toxic multinodular goiter. The two diseases may coexist or may be present at different moments in the same patient. In the literature, there are many reports on the development of Graves' disease after radioiodine treatment for AFTN, but very little information may be found on the occurrence of AFTN after radioiodine therapy for Graves' disease. We describe here the case of a female patient with Graves' disease who was successfully treated with radioiodine for Graves' disease, returning to normal thyroid function. Three years later, biochemical analysis and ultrasound examination identified a thyroid nodule that progressively increased in size. The 99mTc-pertechnetate scintigraphy showed avid uptake in the right lobule, which corresponded to a nodular lesion consistent with AFTN.
authors.affiliation: Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giuffrida
authors.affiliation: Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Giovinazzo
authors.affiliation: Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Certo
authors.affiliation: Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Italy.
authors.forename: Teresa Manuela
authors.initials: TM
authors.lastname: Vicchio
authors.affiliation: Department of Biomedical Sciences and of Morphological and Functional Images, Unit of Nuclear Medicine, University of Messina, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Baldari
authors.affiliation: Department of Biomedical Sciences and of Morphological and Functional Images, Unit of Nuclear Medicine, University of Messina, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Campennì
authors.affiliation: Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Italy.
authors.forename: Rosaria Maddalena
authors.initials: RM
authors.lastname: Ruggeri
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D035583:Rare Diseases / Q000209:etiology; D013670:Sodium Pertechnetate Tc 99m; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D016606:Thyroid Nodule / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013972:Thyrotropin; D013670:Sodium Pertechnetate Tc 99m