title: Association of Lhermitte-Duclos disease and split cord malformation in a child.
abstract: Lhermitte-Duclos disease (LDD) or cerebellar gangliocytoma is a rare pathological entity, the etiology of which remains controversial. Numerous developmental anomalies are known to be associated with LDD, but the association between LDD and split cord malformation (SCM) has not been reported to our knowledge. We report LDD in a 3-year-old girl in whom repetitive urinary tract infections led to the diagnosis of a neurogenic bladder. Thorough screening revealed a SCM at the thoracic level which was surgically repaired. The pathogenesis of this entity and management strategies are discussed in this paper.
authors.affiliation: Department of Neurosurgery, Division of Spine Surgery, Paris Descartes University and Sainte-Anne University Hospital, Paris, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Abi Lahoud
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA.
authors.forename: Nohra
authors.initials: N
authors.lastname: Chalouhi
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Zanaty
authors.affiliation: Department of Neurosurgery, Hotel Dieu de France, Beirut, Lebanon.
authors.forename: Tony
authors.initials: T
authors.lastname: Rizk
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA. Electronic address: pascal.jabbour@jefferson.edu.
authors.forename: Pascal
authors.initials: P
authors.lastname: Jabbour
mesh_terms: D002528:Cerebellar Neoplasms / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005729:Ganglioneuroma / Q000175:diagnosis; D006223:Hamartoma Syndrome, Multiple / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D019635:Neurosurgical Procedures; D013116:Spinal Cord / Q000002:abnormalities* / Q000601:surgery*; D013904:Thoracic Vertebrae; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000209:etiology; D014552:Urinary Tract Infections / Q000209:etiology* / Q000382:microbiology
keywords: Cowden syndrome; Dysplastic cerebellar gangliocytoma; Lhermitte–Duclos disease; Split cord malformation