title: Endoscopic ultrasound-guided fine needle aspiration cytology and biopsy in the evaluation of lymphoma.
abstract: Accurate diagnosis and subtyping of lymphoma have important prognostic implications and are generally required for treatment planning. Histological assessment, immunophenotyping, and genetic studies are usually necessary. Endoscopic ultrasound guided-fine needle aspiration cytology (EUS-FNAC) is a minimally invasive technique widely used for the evaluation of deep-seated benign and malignant lesions. However, the value of cytological samples in lymphoma diagnosis is still a matter of debate. Endoscopic ultrasound guided-fine needle biopsy (EUS-FNAB) can provide tissue core samples that may help overcome the limitations of cytology. The aim of this review is to summarize the available literature regarding EUS-FNAC and EUS-FNAB for the diagnosis and subtyping of lymphoma. In addition, we discuss its usefulness in the management of primary extra-nodal lymphomas, as well as technical issues that may influence sample quality.
authors.affiliation: Gastroenterology Department, University Hospital of Canary Islands, La Laguna, Tenerife, Spain.
authors.forename: Antonio Z
authors.initials: AZ
authors.lastname: Gimeno-García
authors.affiliation: Internal Medicine Department, Gastroenterology Unit, Alhossien Hospital, Alazhar University, Cairo, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elwassief
authors.affiliation: Gastroenterology Department, Saint Luc Hospital, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Sarto C
authors.initials: SC
authors.lastname: Paquin
authors.affiliation: Gastroenterology Department, Saint Luc Hospital, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Anand V
authors.initials: AV
authors.lastname: Sahai
keywords: biopsy; cytology; endoscopic ultrasound; fine needle aspiration; lymphoma