title: Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma.
abstract: We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms was performed in a 384-well plate format on the Sequenom MassARRAY platform. We found that individuals with the XRCC1 399AA genotype had a higher risk of HCC compared with the GG genotype (odds ratio, OR = 1.85, 95% confidence interval, CI = 1.03-3.23). Similarly, individuals carrying the XPD 751GG genotype showed a greatly increased risk of HCC (OR = 2.97, 95%CI = 126- 7.38). Cox regression analysis showed that individuals carrying XPD 751Gln/Gln genotypes had a 0.30-fold increased risk of death from HCC. These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in HCC.
authors.affiliation: Oncology Department, Hainan Province Nongken Nada Hospital, Danzhou, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Wu
authors.affiliation: Department of Digestive System, Hainan Province Nongken Nada Hospital, Danzhou, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Hainan Province Nongken Sanya Hospital, Danzhou, China.
authors.forename: L C
authors.initials: LC
authors.lastname: Wang
authors.affiliation: Department of Digestive System, Hainan Province Nongken Sanya Hospital, Danzhou, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Oncology Department, Hainan Province Nongken Nada Hospital, Danzhou, China.
authors.forename: C W
authors.initials: CW
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Hainan Province Nongken Sanya Hospital, Danzhou, China houbenxin2010@sina.com.
authors.forename: B X
authors.initials: BX
authors.lastname: Hou
authors.affiliation: Department of General Surgery, Ninth People's Hospital, Chongqing, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: He
authors.affiliation: Department of General Surgery, Ninth People's Hospital, Chongqing, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Chen
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human