title: Postsynthetic modification of an amino-tagged MOF using peptide coupling reagents: a comparative study.
abstract: The suitability of four peptide coupling reagents for postsynthetic modification (PSM) of amino-tagged metal-organic frameworks (MOFs) with carboxylic acids was investigated. Mild reaction conditions at room temperature allow effective covalent attachment of drugs and biomolecules inside the pores of MOFs with moderate chemical stability.
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany. stefan.wuttke@cup.uni-muenchen.de.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hintz
authors.forename: Stefan
authors.initials: S
authors.lastname: Wuttke
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000535:Aluminum / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013696:Temperature
chemical_list: D002264:Carboxylic Acids; D008670:Metals; D010455:Peptides; D004364:Pharmaceutical Preparations; D000535:Aluminum; D019342:Acetic Acid