title: Highly enantioselective synthesis of chiral cyclic allylic amines via Rh-catalyzed asymmetric hydrogenation.
abstract: Highly regioselective and enantioselective asymmetric hydrogenation of cyclic dienamides catalyzed by an Rh-DuanPhos complex has been developed, which provides a readily accessible method for the synthesis of chiral cyclic allylic amines in excellent enantioselectivities (up to 99% ee). The products are valuable chiral building blocks and could be easily transformed to multisubstituted cyclohexane derivatives.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Tang-Lin
authors.initials: TL
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.forename: Zejian
authors.initials: Z
authors.lastname: Xue
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001555:Benzene Derivatives; D012238:Rhodium