title: Dynamic contrast-enhanced magnetic resonance imaging: applications in oncology.
abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) allows functional characterisation of tissue perfusion characteristics and acts as a biomarker for tumour angiogenesis. It involves serial acquisition of MRI images before and after injection of contrast, as such, tissue perfusion and permeability can be assessed based on the signal enhancement kinetics. The ability to evaluate whole tumour volumes in a non-invasive manner makes DCE MRI especially attractive for potential oncological applications. Here we provide an overview of the current research involving DCE MRI as a biomarker for the diagnosis and characterisation of malignancies, prediction of the therapeutic response and survival outcomes, as well as radiation therapy planning.
authors.affiliation: Duke NUS Graduate Medical School Singapore, Singapore.
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Teo
authors.affiliation: Department of Oncologic Imaging, National Cancer Centre Singapore, Singapore.
authors.forename: C H
authors.initials: CH
authors.lastname: Thng
authors.affiliation: Department of Oncologic Imaging, National Cancer Centre Singapore, Singapore.
authors.forename: T S
authors.initials: TS
authors.lastname: Koh
authors.affiliation: Department of Medical Oncology, National Cancer Centre Singapore, Singapore. Electronic address: Ng.Q.S@nccs.com.sg.
authors.forename: Q S
authors.initials: QS
authors.lastname: Ng
mesh_terms: D000818:Animals; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis*
chemical_list: D003287:Contrast Media
keywords: Angiogenesis; dynamic contrast-enhanced imaging; functional imaging; magnetic resonance imaging; perfusion imaging