title: Risk factors for anaplastic thyroid cancer.
abstract: Background. Anaplastic thyroid cancer (ATC) is a form of thyroid cancer with very poor prognosis, but is fortunately quite rare. Its aetiology is unknown and not well researched. Aim. The aim of this study was to identify potential risk factors for ATC. Material and Method. Case-control study of 126 ATC patients (77 females and 49 males) and 252 controls individually matched by gender, age, and place of abode. In statistical analysis we used a Cox regression model. Results. Univariate logistic regression showed that the risk factors for ATC are low education level, type B blood group, goitre, other nonthyroid malignancies, diabetes, late menarche, and an early first pregnancy. Multivariate logistic regression analysis showed that independent risk factors for ATC are low education level (OR = 1.42, 95% CI = 1.09-1.86), type B blood group (OR = 2.41, 95% CI = 1.03-5.66), and goitre (OR = 25-33, 95% CI = 5.66-126.65). Conclusion. Independent risk factors for ATC are: low education level, type B blood group, and goitre.
authors.affiliation: Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
authors.forename: V
authors.initials: V
authors.lastname: Zivaljevic
authors.affiliation: Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia.
authors.forename: N
authors.initials: N
authors.lastname: Slijepcevic
authors.affiliation: Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
authors.forename: I
authors.initials: I
authors.lastname: Paunovic
authors.affiliation: Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
authors.forename: A
authors.initials: A
authors.lastname: Diklic
authors.affiliation: Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
authors.forename: N
authors.initials: N
authors.lastname: Kalezic
authors.affiliation: School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia ; Institute of Medical Statistics and Informatics, School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
authors.forename: J
authors.initials: J
authors.lastname: Marinkovic
authors.affiliation: Clinical Centre "Dr Dragisa Misovic", Heroja Milana Tepica 1, 11000 Belgrade, Serbia.
authors.forename: R
authors.initials: R
authors.lastname: Zivic
authors.affiliation: Clinical Centre "Dr Dragisa Misovic", Heroja Milana Tepica 1, 11000 Belgrade, Serbia.
authors.forename: B
authors.initials: B
authors.lastname: Vekic
authors.affiliation: School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia ; Institute of Epidemiology, School of Medicine, University of Belgrade, Visegradska 26A, 11000 Belgrade, Serbia.
authors.forename: S
authors.initials: S
authors.lastname: Sipetic