title: The Effects of 6 Isocaloric Meals on Body Weight, Lipid Profiles, Leptin, and Adiponectin in Overweight Subjects (BMI > 25).
abstract: BACKGROUND
  It seems that meal frequency is negatively related to body weight, but the relationship between meal frequency and weight loss is not clearly known yet.
  
  
  OBJECTIVE
  The present study aimed to investigate whether 6 isocaloric meals affected body weight, lipid profiles, leptin, and adiponectin in overweight subjects.
  
  
  METHODS
  The present randomized controlled trial was conducted on 90 overweight subjects in 3 months. The subjects were randomly divided into two groups. The control group continued their normal diet, while the intervention group was required to follow a 6 isocaloric meal diet instead of their previous meal pattern (3 meals and 2 snacks). The planned reduced calorie diets for both groups were identical, except for meal pattern. Blood samples were analyzed prior to and at the end of the study for total cholesterol, triglyceride, HDL-C, LDL-C, leptin, and adiponectinn concentrations. Paired t-test was used for comparison of the measurements before and after the study in each group. Besides, independent t-test was used for comparison of the measurements between the groups. P value less than 0.05 was considered as statistically significant.
  
  
  RESULTS
  The mean age of the participants was 36.38 ± 9.7 in the intervention group and 37.6 ± 10.9 in the control group. In comparison to the control group, the intervention group showed a significant decrease in total cholesterol (P < 0.001), LDL-C (P < 0.001), BMI (P < 0.001), triglyceride (P < 0.001), and leptin (P = 0.002) and a significant increase in HDL (P < 0.001) and adiponectin (P = 0.031).
  
  
  CONCLUSIONS
  The 6 isocaloric meal pattern led to a reduction in BMI, lipid profiles (total cholesterol, LDL-C, triglyceride), and leptin concentrations and an increase in HDL and adiponectin compared to the normal diet.
authors.affiliation: Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Zeynab
authors.initials: Z
authors.lastname: Hatami Zargaran
authors.affiliation: Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Moosa
authors.initials: M
authors.lastname: Salehi
authors.affiliation: Research Center for Cardiovascular Atherosclerosis, Jahrom University of Medical Sciences, Jahrom, IR Iran.
authors.forename: Seyed Taghi
authors.initials: ST
authors.lastname: Heydari
authors.affiliation: Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Siavash
authors.initials: S
authors.lastname: Babajafari
keywords: Adiponectin; Leptin; Meal; Obesity