title: Regulation of crp gene expression by the catabolite repressor/activator, Cra, in Escherichia coli.
abstract: Growth of E. coli on several carbon sources is dependent on the catabolite repressor/activator (Cra) protein although a Cra consensus DNA-binding site is not present in the control regions of the relevant catabolic operons. We show that Cra regulates growth by activating expression of the crp gene. It thereby mediates catabolite repression of catabolic operons by an indirect mechanism.
authors.affiliation: Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, Calif., USA.
authors.forename: Zhongge
authors.initials: Z
authors.lastname: Zhang
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aboulwafa
authors.forename: Milton H
authors.initials: MH
authors.lastname: Saier
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D002373:Cyclic AMP Receptor Protein / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D012097:Repressor Proteins / Q000378:metabolism*; D056968:Lac Repressors
chemical_list: D001426:Bacterial Proteins; D002373:Cyclic AMP Receptor Protein; D029968:Escherichia coli Proteins; D012097:Repressor Proteins; C481662:crp protein, E coli; C068837:FruR protein, Bacteria; D056968:Lac Repressors