title: Capecitabine induced colitis.
abstract: Capecitabine is an oral prodrug to 5-fluorouracil and is commonly used in the treatment of advanced breast, colon and stomach cancer. While gastrointestinal toxicity is common, enterocolitis and ischemic colitis are uncommon complications and the histologic features of capecitabine in the colonic mucosa have not been previously described. We present a case of colitis attributed to capecitabine toxicity in a 45-year-old man undergoing treatment of metastatic gastroesophageal adenocarcinoma. Possible pathophysiologic mechanisms of capecitabine toxicity are discussed and the histologic effects on the colon are described.
authors.affiliation: Saba University School of Medicine, Dutch Caribbean, Bonaire, Sint Eustatius and Saba.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Maggo
authors.affiliation: Division of Gastroenterology, St. Michael's Hospital, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.
authors.forename: Samir C
authors.initials: SC
authors.lastname: Grover
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. Electronic address: grina@smh.ca.
authors.forename: Andrea
authors.initials: A
authors.lastname: Grin
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000069287:Capecitabine; D003092:Colitis / Q000139:chemically induced*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil
keywords: Adverse effects; Capecitabine; Chemotherapy; Ischemic colitis