title: RNA-seq permits a closer look at normal skin and psoriasis gene networks.
abstract: Psoriasis is a chronic inflammatory skin disease driven by aberrant signals from the immune system. In this issue, Li et al. present the first large RNA-seq analysis of gene expression in normal skin and psoriasis lesions, providing a more comprehensive view of mRNA expression than earlier microarray studies. This study's size enables gene co-expression analysis, a method illustrating which pathways are altered by the presence of disease.
authors.affiliation: Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA; Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway; Faculty of Medicine, K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: dquigley@cc.ucsf.edu.
authors.forename: David
authors.initials: D
authors.lastname: Quigley
mesh_terms: D004817:Epidermis / Q000502:physiology*; D006801:Humans; D011565:Psoriasis / Q000235:genetics*; D059467:Transcriptome / Q000235:genetics*