title: A new cyclopeptide metabolite of marine gut fungus from Ligia oceanica.
abstract: A new cyclopeptide, together with three known amino acid derivatives, was isolated from marine-derived fungus Aspergillus flavipes, which was found in the gut of isopod Ligia oceanica. The novel peptide contains four amino acid units, proline, 5-methoxyanthranilic acid, isoleucine and 3-aminoacrylic acid. Its structure was determined on the basis of NMR, HR-MS and MS(n) spectral data analysis. The two unusual amino acid residues, 5-methoxyanthranilic acid and 3-aminoacrylic acid, were first found in natural product. The known compound N-benzoyl-phenylalanine methyl ester was first found as fungal metabolite. This is the first report of natural products isolated from marine gut fungi.
authors.affiliation: a Institute of Marine Biology, Ocean College, Zhejiang University , Hangzhou 310058 , P.R. China.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Xu
authors.forename: Shizhe
authors.initials: S
authors.lastname: Zhao
authors.forename: Xianwen
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D002681:China; D033321:Isopoda / Q000382:microbiology*; D008386:Marine Biology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D062368:meta-Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C582649:5-methoxyanthranilic acid; D010456:Peptides, Cyclic; D062368:meta-Aminobenzoates
keywords: 3-aminoacrylic acid; 5-methoxyanthranilic acid; Aspergillus flavipes; cyclopeptide; gut fungus