title: Endoscopic Ultrasound-Guided Fine Needle Aspiration versus Percutaneous Ultrasound-Guided Fine Needle Aspiration in Diagnosis of Focal Pancreatic Masses.
abstract: OBJECTIVE
  Pancreatic carcinoma is one of the leading cancer morbidity and mortality world-wide. Controversy has arisen about whether the percutaneous approach with computed tomography/ultrasonography-guidance fine needle aspiration (US-FNA) or endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the preferred method to obtain diagnostic tissue. Our purpose of this study is to compare between the diagnostic accuracy of EUS-FNA and percutaneous US-FNA in diagnosis of pancreatic cancer.
  
  
  METHODS
  A total of 197 patients with pancreatic masses were included in the study, 125 patients underwent US-FNA (Group 1) and 72 patients underwent EUS-FNA (Group 2).
  
  
  RESULTS
  EUS-FNA has nearly the same accuracy (88.9%) as US-FNA (87.2%) in diagnosis of pancreatic cancer. The sensitivity, specificity, positive predictive value and negative predictive value for EUS-FNA was 84%, 100%, 100%, 73.3% respectively. It was 85.5%, 90.4%, 94.7%, 76% respectively for US-FNA. EUS-FNA had a lower complication rate (1.38%) than US-FNA (5.6%).
  
  
  CONCLUSIONS
  EUS-FNA has nearly the same accuracy as US-FNA of pancreatic masses with a lower complication rate.
authors.affiliation: Internal Medicine and Gastroenterology Department, Cairo University, Egypt.
authors.forename: Hussein Hassan
authors.initials: HH
authors.lastname: Okasha
authors.affiliation: Internal Medicine and Gastroenterology Department, Cairo University, Egypt.
authors.forename: Mazen Ibrahim
authors.initials: MI
authors.lastname: Naga
authors.affiliation: Internal Medicine and Gastroenterology Department, Cairo University, Egypt.
authors.forename: Serag
authors.initials: S
authors.lastname: Esmat
authors.affiliation: Internal Medicine and Gastroenterology Department, Cairo University, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Naguib
authors.affiliation: National Hepatology and Tropical Medicine Research Institute (NHTMRI); Assiut, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hassanein
authors.affiliation: National Hepatology and Tropical Medicine Research Institute (NHTMRI); Assiut, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hassani
authors.affiliation: National Hepatology and Tropical Medicine Research Institute (NHTMRI); Assiut, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Kassas
authors.affiliation: Internal Medicine and Gastroenterology Department, Assiut University, Egypt.
authors.forename: Reem Ezzat
authors.initials: RE
authors.lastname: Mahdy
authors.affiliation: Pathology Department, National Cancer Institute (NCI), Egypt.
authors.forename: Emad
authors.initials: E
authors.lastname: El-Gemeie
authors.affiliation: Internal Medicine and Gastroenterology Department, Cairo University, Egypt.
authors.forename: Ali Hassan
authors.initials: AH
authors.lastname: Farag
authors.affiliation: Internal Medicine and Gastroenterology Department, Cairo University, Egypt.
authors.forename: Ayman Mohamed
authors.initials: AM
authors.lastname: Foda
keywords: endoscopic ultrasound; fine needle aspiration; pancreatic cancer; ultrasound