title: Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population.
abstract: BACKGROUND
  The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.
  
  
  RESULTS
  A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls.
  
  
  CONCLUSIONS
  Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.
authors.affiliation: Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. francesca.megiorni@uniroma1.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Megiorni
authors.forename: Serena
authors.initials: S
authors.lastname: Resta
authors.forename: Deliar
authors.initials: D
authors.lastname: Yazdanian
authors.forename: Gabriele
authors.initials: G
authors.lastname: Cavaggioni
authors.forename: Claudia
authors.initials: C
authors.lastname: Lia
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Benedetti Panici
authors.forename: Antonio
authors.initials: A
authors.lastname: Pizzuti
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Porpora
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods*; D011401:Promoter Regions, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins