title: The lectin pathway of complement: advantage or disadvantage in HIV pathogenesis?
abstract: The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.
authors.affiliation: Viro-Immunology, Department of Infectious Diseases, Rigshospitalet (Copenhagen University Hospital), Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Ballegaard
authors.affiliation: Viro-Immunology, Department of Infectious Diseases, Rigshospitalet (Copenhagen University Hospital), Denmark.
authors.forename: A K
authors.initials: AK
authors.lastname: Haugaard
authors.affiliation: Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet (Copenhagen University Hospital), Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Garred
authors.affiliation: Viro-Immunology, Department of Infectious Diseases, Rigshospitalet (Copenhagen University Hospital), Denmark. Electronic address: sdn@dadlnet.dk.
authors.forename: S D
authors.initials: SD
authors.lastname: Nielsen
authors.affiliation: Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet (Copenhagen University Hospital), Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Munthe-Fog
mesh_terms: D037582:Complement Pathway, Mannose-Binding Lectin / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D011110:Polymorphism, Genetic
keywords: Collectin-11; Ficolin-1, -2 and -3; HIV; Innate immunity; Lectin pathway; Mannose-binding lectin (MBL)