title: The ins and outs of angiotensin processing within the kidney.
abstract: The kidney is a key target organ for bioactive components of the renin-angiotensin system (RAS); however, various renal cells such as the tubular epithelium contain an intrinsic RAS. The renal RAS can be functionally divided into ANG II-AT1 receptor and ANG-(1-7)-AT7/Mas receptor arms that functionally oppose one another. The current review considers both extracellular and intracellular pathways that potentially govern the formation and metabolism of angiotensin peptides within the renal proximal tubules.
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Wilson
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
authors.forename: Allyson C
authors.initials: AC
authors.lastname: Marshall
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
authors.forename: Ebaa M
authors.initials: EM
authors.lastname: Alzayadneh
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina mchappel@wakehealth.edu.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Chappell
mesh_terms: D000803:Angiotensin I / Q000502:physiology; D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D010446:Peptide Fragments / Q000502:physiology; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: D000809:Angiotensins; D010446:Peptide Fragments; D044140:Receptor, Angiotensin, Type 1; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: angiotensin II; angiotensin-(1–7); fetal programming; kidney; metabolism; peptidase