title: Expression of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in response to environmental gut conditions.
abstract: Cell surface pili have recently been found in many different bifidobacterial species, including the infant gut commensal Bifidobacterium bifidum PRL2010. Pili produced by PRL2010 have been shown to be important molecular mediators for bacterial interaction with its human host. However, nothing is known about the modulation of their expression in response to cues that reflect the gastro intestinal environment, such as thermal, acidic, and osmotic challenges, or the presence of other gut microorganisms. Here, we investigated how different stress conditions that simulate the gastrointestinal niche influence the expression of PRL2010 sortase-dependent pili, and how this may impact on the coexistence and interaction with other human gut commensals.
authors.affiliation: Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland.
authors.forename: Francesca
authors.initials: F
authors.lastname: Turroni
authors.forename: Fausta
authors.initials: F
authors.lastname: Serafini
authors.forename: Marta
authors.initials: M
authors.lastname: Mangifesta
authors.forename: Stefania
authors.initials: S
authors.lastname: Arioli
authors.forename: Diego
authors.initials: D
authors.lastname: Mora
authors.forename: Douwe
authors.initials: D
authors.lastname: van Sinderen
authors.forename: Marco
authors.initials: M
authors.lastname: Ventura
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D001644:Bifidobacterium / Q000235:genetics*; D004777:Environment; D010861:Fimbriae, Bacterial / Q000235:genetics*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D015870:Gene Expression / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans
chemical_list: D001426:Bacterial Proteins
keywords: Bifidobacteria; genomics; host-microorganism interaction; microorganism-microorganism interaction