title: Modulation of CD6 function through interaction with Galectin-1 and -3.
abstract: CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Escoda-Ferran
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Carrasco
authors.affiliation: Servei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, 08036 Barcelona, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Caballero-Baños
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Miró-Julià
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Martínez-Florensa
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Consuegra-Fernández
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain.
authors.forename: Vanesa G
authors.initials: VG
authors.lastname: Martínez
authors.affiliation: Department of Dermatology, UC Davis School of Medicine, Sacramento, CA 95816, United States.
authors.forename: Fu-Tong
authors.initials: FT
authors.lastname: Liu
authors.affiliation: From Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, 08036 Barcelona, Spain; Servei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, 08036 Barcelona, Spain; Departament de Biologia Cel lular, Immunologia i Neurociències, Facultat de Medicina Universitat de Barcelona, 08036 Barcelona, Spain. Electronic address: flozano@clinic.ub.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
mesh_terms: D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000378:metabolism*; D015703:Antigens, CD / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology; D050260:Carbohydrate Metabolism; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D037483:Galectin 1 / Q000378:metabolism*; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D018089:Superantigens / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D020410:Activated-Leukocyte Cell Adhesion Molecule; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C062279:CD6 antigen; D037483:Galectin 1; D037502:Galectin 3; D018089:Superantigens
keywords: ALCAM/CD166; Apoptosis; CD6; Cell adhesion; Galectin; T-cell activation