title: Mosaic Turner syndrome associated with schizophrenia.
abstract: Turner syndrome is a sex-chromosome disorder; occurring in 1 in 2,500 female births. There are sporadic few case reports of concomitant Turner syndrome with schizophrenia worldwide. Most Turner females had a 45,X monosomy, whereas the majority of comorbidity between Turner syndrome and schizophrenia had a mosaic karyotype (45,X/46,XX). We present a case of a 21-year-old woman with Turner syndrome, mosaic karyotype (45,X/46,XX), showing mental retardation, hypothyroidism, and schizophrenia. HOPA gene within Xq13 is related to mental retardation, hypothyroidism, and schizophrenia. Our case may be a potential clue which supports the hypothesis for involvement of genes on X chromosome in development of schizophrenia. Further studies including comorbid cases reports are need in order to discern the cause of schizophrenia in patients having Turner syndrome.
authors.affiliation: Department of Pediatrics, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
authors.forename: Sook Young
authors.initials: SY
authors.lastname: Jung
authors.affiliation: Inha University School of Medicine, Incheon, Korea.
authors.forename: Joo Won
authors.initials: JW
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
authors.forename: Yong Hoon
authors.initials: YH
authors.lastname: Jun
authors.affiliation: Department of Psychiatry, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
authors.forename: Jeong Seop
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
keywords: Mosaicism; Schizophrenia; Turner syndrome; X chromosome