title: Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.
abstract: To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. The median follow-up was 24 months. The cumulative incidence of neutrophil recovery at 60 days was 80%. Fifteen patients relapsed after UCBT. The 2-year overall survival and event-free-survival (EFS) rates were 44% and 30%, respectively. All patients given TCF achieved neutrophil and platelet recovery, and the use of TCF was associated with superior EFS in the RIC population (44% versus 0%, P = .001). Patients with transformation to AML had similar outcomes to patients with less advanced stages. In conclusion, despite graft failure remaining a major concern, the role of UCBT in the management of MF, especially using RIC TCF-based regimens, deserves further investigation to improve results.
authors.affiliation: Hematology-Bone Marrow Transplantation, Saint-Louis Hospital, Paris, France. Electronic address: marie.robin@paris7.jussieu.fr.
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.affiliation: Eurocord International Registry, Hôpital Saint-Louis, Paris, France.
authors.forename: Federica
authors.initials: F
authors.lastname: Giannotti
authors.affiliation: Service d'Hématologie, CHU de Besançon, INSERM U-645, Université de Franche-Comté, Besançon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deconinck
authors.affiliation: Hematologie, CHU Saint-Antoine, Paris, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Hematology Department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France.
authors.forename: Mauricette
authors.initials: M
authors.lastname: Michallet
authors.affiliation: Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Sanz
authors.affiliation: Hematology, Nantes University Hospital, Nantes, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Chevallier
authors.affiliation: Department of Hematology, University Hospital, Grenoble, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Cahn
authors.affiliation: Hematology, Nice University Hospital, Nice, France.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Legrand
authors.affiliation: Hematology, Hospital Clínic, IDIBAPS, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rovira
authors.affiliation: Hematology Department, Basel University Hospital, Basel, Switzerland.
authors.forename: Jakob
authors.initials: J
authors.lastname: Passweg
authors.affiliation: Clinical Hematology, Hospital De Sant Pau, Barcelona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Sierra
authors.affiliation: Hematology, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Nguyen
authors.affiliation: CHU Hematology, Poitiers, France.
authors.forename: Natacha
authors.initials: N
authors.lastname: Maillard
authors.affiliation: Hematology, CHRU de Lille, Lille, France.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
authors.affiliation: Medical University Graz, Graz, Austria.
authors.forename: Werner
authors.initials: W
authors.lastname: Linkesch
authors.affiliation: Hematology, Royal Perth Hospital, Perth, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Cannell
authors.affiliation: Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Magda
authors.initials: M
authors.lastname: Marcatti
authors.affiliation: Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, Hotel-Dieu, Clermont-Ferrand, France.
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Bay
authors.affiliation: Hôpitaux universitaires de Genève, Suisse.
authors.forename: Yves
authors.initials: Y
authors.lastname: Chalandon
authors.affiliation: University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg, Germany.
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Kröger
authors.affiliation: Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Monacord, Centre scientifique de Monaco, Monaco.
authors.forename: Eliane
authors.initials: E
authors.lastname: Gluckman
authors.affiliation: Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Department of Clinical Haematology, Bone Marrow Transplant Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.
authors.forename: Vanderson
authors.initials: V
authors.lastname: Rocha
authors.affiliation: Hospital de Navarra, Chairman of MPN Subcommittee of the CMWP-EBMT, Pamplona, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Olavarria
authors.affiliation: Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Hematologie, CHU Saint-Antoine, Paris, France.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Ruggeri
mesh_terms: D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005312:Fetal Blood; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome; D061349:Unrelated Donors
keywords: Myelofibrosis; Umbilical cord blood transplantation