title: Neuroimaging to investigate multisystem involvement and provide biomarkers in amyotrophic lateral sclerosis.
abstract: Neuroimaging allows investigating the extent of neurological systems degeneration in amyotrophic lateral sclerosis (ALS). Advanced MRI methods can detect changes related to the degeneration of upper motor neurons but have also demonstrated the participation of other systems such as the sensory system or basal ganglia, demonstrating in vivo that ALS is a multisystem disorder. Structural and functional imaging also allows studying dysfunction of brain areas associated with cognitive signs. From a biomarker perspective, numerous studies using diffusion tensor imaging showed a decrease of fractional anisotropy in the intracranial portion of the corticospinal tract but its diagnostic value at the individual level remains limited. A multiparametric approach will be required to use MRI in the diagnostic workup of ALS. A promising avenue is the new methodological developments of spinal cord imaging that has the advantage to investigate the two motor system components that are involved in ALS, that is, the lower and upper motor neuron. For all neuroimaging modalities, due to the intrinsic heterogeneity of ALS, larger pooled banks of images with standardized image acquisition and analysis procedures are needed. In this paper, we will review the main findings obtained with MRI, PET, SPECT, and nuclear magnetic resonance spectroscopy in ALS.
authors.affiliation: Sorbonne Universités, UPMC Universités Paris 06, UMR 7371, UMR-S 1146, LIB, 75005 Paris, France ; CNRS, UMR 7371, LIB, 75005 Paris, France ; INSERM, UMR-S 1146, LIB, 75005 Paris, France ; Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière (AP-HP), 75005 Paris, France.
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Pradat
authors.affiliation: Sorbonne Universités, UPMC Universités Paris 06, UMR 7371, UMR-S 1146, LIB, 75005 Paris, France ; CNRS, UMR 7371, LIB, 75005 Paris, France ; INSERM, UMR-S 1146, LIB, 75005 Paris, France.
authors.forename: Mohamed-Mounir
authors.initials: MM
authors.lastname: El Mendili
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D015415:Biomarkers / Q000737:chemistry; D001921:Brain / Q000000981:diagnostic imaging; D056324:Diffusion Tensor Imaging / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D009046:Motor Neurons / Q000000981:diagnostic imaging; D059906:Neuroimaging; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: D015415:Biomarkers