title: Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery.
abstract: Liposomes are widely used as drug delivery systems and several liposome-based nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have been decorated onto nanoparticulated vesicle such as liposomes to further improve the intracellular delivery efficiency. However, the poor selectivity of CPPs hindered their application, especially in the in vivo application. To resolve this issue, several strategies have been developed, including shielding and environment-triggered deshielding of CPPs as well as designing of environment-responsive CPPs and specific- targeting CPPs and last but not least, combination strategy. In this review, the abovementioned strategies were discussed.
authors.forename: Huile
authors.initials: H
authors.lastname: Gao
authors.forename: Qianyu
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China. qinhe@scu.edu.cn.
authors.forename: Qin
authors.initials: Q
authors.lastname: He
mesh_terms: D000818:Animals; D057846:Cell-Penetrating Peptides / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D008081:Liposomes
chemical_list: D057846:Cell-Penetrating Peptides; D008081:Liposomes