title: Nod-like receptors have a grip on stem cells.
abstract: Two reports in this issue of Cell Host & Microbe establish that Nod-like receptor proteins NOD1 and NOD2 regulate stem cell function. Burberry et al. (2014) demonstrate that NOD1 and NOD2 synergize with TLRs to mobilize hematopoietic stem cells. Nigro et al. (2014) report that NOD2 provides cytoprotection to intestinal stem cells.
authors.affiliation: Department of Microbiology and Immunology, Department of Physiology, Complex Traits Group, McGill University, Bellini Pavilion Room 371, 3649 Promenade Sir-William Osler, Montreal, QC H3G 0B1, Canada. Electronic address: jorg.fritz@mcgill.ca.
authors.forename: Jörg H
authors.initials: JH
authors.lastname: Fritz
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D004927:Escherichia coli Infections / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006412:Hematopoietic Stem Cells / Q000382:microbiology*; D053474:Nod1 Signaling Adaptor Protein / Q000378:metabolism*; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D053474:Nod1 Signaling Adaptor Protein; C507873:Nod1 protein, mouse; D053473:Nod2 Signaling Adaptor Protein; C495945:Nod2 protein, mouse; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D000119:Acetylmuramyl-Alanyl-Isoglutamine