title: Intercellular adhesion molecule-1 K469E and angiotensinogen T207M polymorphisms in coronary slow flow.
abstract: OBJECTIVE
  To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF).
  
  
  METHODS
  The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ICAM1 (rs5498) and the T207M polymorphism of AGT (rs4762) were determined using the polymerase chain reaction amplification method.
  
  
  RESULTS
  Baseline demographic parameters were similar in both groups. The mean thrombolysis in myocardial infarction frame count was significantly higher in patients with CSF (23.8 ± 5.1) compared to the controls (13.3 ± 2.6, p < 0.001). A significant association was found between the ICAM1 K allele and CSF (OR: 1.96, 95% CI: 1.15-3.35, p = 0.013). There was no difference in the frequency of AGT T207M genotypes in the patients with CSF and the control subjects.
  
  
  CONCLUSIONS
  This study showed that K469E polymorphisms of ICAM1 that play a role in atherosclerotic pathogenesis are related to CSF.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Gazi
authors.forename: Ahmet
authors.initials: A
authors.lastname: Barutcu
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.forename: Adem
authors.initials: A
authors.lastname: Bekler
authors.forename: Mine
authors.initials: M
authors.lastname: Urfali
authors.forename: Fatma
authors.initials: F
authors.lastname: Silan
authors.forename: Yucel
authors.initials: Y
authors.lastname: Colkesen
authors.forename: Ozturk
authors.initials: O
authors.lastname: Ozdemir
mesh_terms: D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology; D003326:Coronary Circulation / Q000235:genetics*; D003331:Coronary Vessels / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D000808:Angiotensinogen; D018799:Intercellular Adhesion Molecule-1