title: [Association of red blood cell and platelet allo-antibodies in platelet alloimmunized patients].
abstract: OBJECTIVE
  Use of matched red blood cell (RBC) concentrates is imperative in patients with RBC allo-antibodies (Abs) and when platelet (PLT) specific allo-Abs are present additional difficulties occur for PLT transfusions. In order to evaluate the prevalence of the PLT and RBC allo-Abs association, a study on patients with PLT specific allo-Acs was performed. This association is not a rare event.
  
  
  METHODS
  In the database of a PLT immunohaematology laboratory, patients with PLT specific allo-Abs were selected and the presence and specificity of RBC allo-Abs was evaluated.
  
  
  RESULTS
  Six hundred and eighty seven patients (673 females, 14 males) with PLT specific allo-Abs were found. Six hundred and seventy-five patients (98.3%) had PLT specific allo-Abs with only one specificity. Anti-HPA-5b was the most frequent (539 cases). Twenty-nine (4.2%) patients had also RBC allo-Abs, including 27 females (93.1%) and two males. Seventy (58.6%) had RBC allo-Abs with only one specificity, 10 several and two unknown. Among the first, RBC allo-Abs directed against Rhesus blood group antigens were predominant (11 cases [64.7%]). Among the 29 patients with associated PLT and RBC allo-Abs, 15 (51.7%) were 50 or more years old and 14 (48.3%) under 50.
  
  
  CONCLUSIONS
  In PLT specific alloimmunized patients, detection of RBC alloimmunization is not a rare event. When RBC and PLT transfusions are required, the supply of matched RBC and PLT concentrates is more difficult.
authors.affiliation: Laboratoire d'immunologie plaquettaire, Établissement français du sang Rhône-Alpes, site de Lyon Gerland, 1-3, rue du Vercors, 69364 Lyon cedex 07, France. Electronic address: pierre.moncharmont@efs.sante.fr.
authors.forename: P
authors.initials: P
authors.lastname: Moncharmont
authors.affiliation: Laboratoire d'immunologie plaquettaire, Établissement français du sang Rhône-Alpes, site de Lyon Gerland, 1-3, rue du Vercors, 69364 Lyon cedex 07, France.
authors.forename: D
authors.initials: D
authors.lastname: Rigal
mesh_terms: D000328:Adult; D000918:Antibody Specificity; D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects; D012204:Rh-Hr Blood-Group System / Q000276:immunology
chemical_list: D016824:Antigens, Human Platelet; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System
keywords: Allo-immunisation; Alloimmunization; Plaquette; Platelet; Receveur; Recipient; Red blood cell; Transfusion; Érythrocyte