title: No detection of 'high-risk' human papillomaviruses in a group of Iranian women with breast cancer.
abstract: The presence of viral DNA in breast cancer cells is controversial. However, some studies have revealed a possible role for the human papillomavirus in the pathogenesis of breast cancer. The aim of the present study was to investigate the presence of HPV-DNA in breast tissue in a group of Iranian women with and without breast cancer and identification of the detected HPV types. Paraffin-embedded specimens from 65 malignant breast cancer cases and 65 cases with benign breast lesions were investigated for presence of HPV-DNA by nested polymerase chain reaction. We found HPV-DNA in 22 (33.8%) of the breast cancer specimens. All non-cancerous specimens were negative. Low and high-risk HPV types, including HPV-6 (26.2%), HPV-16 (1.5%), HPV-35 (1.5%), HPV-52 (1.5%), and HPV-11 (1.5%) were detected in our study. HPV-6 was the most prevalent type in the breast cancer specimens. Although high-risk HPV types have been shown to have a major role in cervix cancer, there have been no data that support the same relevance for other types of malignancies. Furthermore, presence of low-risk HPV types in malignancies still is a matter of debate. The data presented in this study indicates a strong need for epidemiological studies correlating different HPV types in human breast cancer.
authors.affiliation: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran E-mail : shahmahmoodi@tums.ac.ir.
authors.forename: Mahin
authors.initials: M
authors.lastname: Ahangar-Oskouee
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahmahmoodi
authors.forename: Somayeh
authors.initials: S
authors.lastname: Jalilvand
authors.forename: Mahmood
authors.initials: M
authors.lastname: Mahmoodi
authors.forename: Abed Ali
authors.initials: AA
authors.lastname: Ziaee
authors.forename: Heidar-Ali
authors.initials: HA
authors.lastname: Esmaeili
authors.forename: Maryam
authors.initials: M
authors.lastname: Keshtvarz
authors.forename: Leila
authors.initials: L
authors.lastname: Pishraft-Sabet
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.forename: Yaghoob
authors.initials: Y
authors.lastname: Mollaei-Kandelous
authors.forename: Talat
authors.initials: T
authors.lastname: Mokhtari-Azad
authors.forename: Rakhshandeh
authors.initials: R
authors.lastname: Nategh
mesh_terms: D000328:Adult; D001483:Base Sequence; D001940:Breast / Q000473:pathology / Q000821:virology; D001943:Breast Neoplasms / Q000235:genetics / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D052140:Human papillomavirus 11 / Q000235:genetics*; D052162:Human papillomavirus 16 / Q000235:genetics*; D052163:Human papillomavirus 6 / Q000235:genetics*; D006801:Humans; D007492:Iran; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000821:virology; D017422:Sequence Analysis, DNA; D014021:Tissue Preservation
chemical_list: D004279:DNA, Viral