title: Paraneoplastic downbeat nystagmus associated with cerebellar hypermetabolism especially in the nodulus.
abstract: A 52-year-old man with vertigo and imbalance for two weeks showed spontaneous downbeat (DBN), horizontal gaze-evoked, and positional apogeotropic nystagmus along with severe limb and truncal ataxia. Gadolinium-enhanced brain MRI was normal, but whole body and brain 2-deoxy-2-[F18]fluoro-d-glucose-positron emission tomography revealed hypermetabolism in the right lower lobe of the lung and the cerebellum, especially in the nodulus. The lesion in the lung was confirmed as mixed cell carcinoma. Paraneoplastic DBN may be associated with cerebellar hypermetabolism, especially in the nodulus.
authors.affiliation: Department of Neurology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
authors.forename: Seo Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Republic of Korea.
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Biomedical Laboratory Science, Kyungdong University, Goseong, Republic of Korea.
authors.forename: Hyo-Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Republic of Korea. Electronic address: jisookim@snu.ac.kr.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Kim
mesh_terms: D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology*; D005133:Eye Movements / Q000502:physiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000209:etiology* / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Ataxia; Downbeat nystagmus; Paraneoplastic syndrome; Vertigo