title: TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.
abstract: High-throughput analyses of RNA and protein expression are increasingly used for better understanding of vaccine-induced immunity and protection against infectious disease. With an increasing number of vaccine candidates in clinical development, it is timely to consider standardisation and harmonisation of sample collection, storage and analysis to ensure results of highest quality from these precious samples. These challenges were discussed by a group of international experts during a workshop organised by TRANSVAC, a European Commission-funded Research Infrastructure project. The main conclusions were: Platforms are rarely standardised for use in preclinical and clinical studies. Coordinated efforts should continue to harmonise the experimental set up of these studies, as well as the establishment of internal standards and controls. This will ensure comparability, efficiency and feasibility of the global analyses performed on preclinical and clinical data sets.
authors.affiliation: European Vaccine Initiative, Heidelberg University Hospital, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. Electronic address: celine.dutruel@euvaccine.eu.
authors.forename: Céline
authors.initials: C
authors.lastname: Dutruel
authors.affiliation: Tuberculosis Vaccine Initiative, Runderweg 6, 8219 PK Lelystad, The Netherlands. Electronic address: jelle.thole@intravacc.nl.
authors.forename: Jelle
authors.initials: J
authors.lastname: Thole
authors.affiliation: European Vaccine Initiative, Heidelberg University Hospital, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. Electronic address: mjgeels@gmail.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Geels
authors.affiliation: Core Facility Microarray, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: mollenkopf@mpiib-berlin.mpg.de.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Mollenkopf
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Center, Bldg. 1, Rm # C-05-44, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address: t.h.m.ottenhoff@lumc.nl.
authors.forename: Tom
authors.initials: T
authors.lastname: Ottenhoff
authors.affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany. Electronic address: carlos.guzman@helmholtz-hzi.de.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Guzman
authors.affiliation: Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Electronic address: helen.fletcher@lshtm.ac.uk.
authors.forename: Helen A
authors.initials: HA
authors.lastname: Fletcher
authors.affiliation: European Vaccine Initiative, Heidelberg University Hospital, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. Electronic address: odile.leroy@euvaccine.eu.
authors.forename: Odile
authors.initials: O
authors.lastname: Leroy
authors.affiliation: Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: kaufmann@mpiib-berlin.mpg.de.
authors.forename: Stefan H E
authors.initials: SHE
authors.lastname: Kaufmann
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000592:standards*; D035843:Biomedical Research / Q000592:standards; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology* / Q000592:standards*; D032581:Tuberculosis Vaccines / Q000276:immunology* / Q000592:standards*; D014611:Vaccination / Q000379:methods / Q000592:standards*
chemical_list: D016915:AIDS Vaccines; D017780:Malaria Vaccines; D032581:Tuberculosis Vaccines
keywords: Biomarkers; HIV; Harmonisation; Malaria; Molecular analyses; Standardisation; TRANSVAC; Tuberculosis; Vaccination