title: The antidiabetic therapeutic potential of dietary polyphenols.
abstract: Type-2 diabetes (T2D) is a complex metabolic syndrome that is characterized by persistent hyperglycemia due to either lack of insulin secretion and/or insulin resistance. The prevalence of T2D along with its major risk factor, obesity, has been increasing with an epidemic proportion in recent years. To date, there is no drug of cure for diabetes and the existing therapeutic approaches have serious drawbacks including side effects and loss of efficacy during prolonged use. Dietary polyphenols are one group of natural products that have shown promise as potential antidiabetic agents. In this review, their molecular mechanisms of action including, antioxidant, anti-inflammatory, receptor agonist/antagonist effect and modulation of key signal transduction cascades, glucose transport, enzyme activity, receptor agonistic/antagonist effect, etc. in major insulin-sensitive cells are discussed.
authors.forename: Solomon
authors.initials: S
authors.lastname: Habtemariam
authors.affiliation: Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK. s.habtemariam@gre.ac.uk.
authors.forename: George K
authors.initials: GK
authors.lastname: Varghese
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D005227:Fatty Acids; D007004:Hypoglycemic Agents; D059808:Polyphenols; D005947:Glucose