title: Intestinal adaptations in chronic kidney disease and the influence of gastric bypass surgery.
abstract: Studies have shown that compensatory adaptations in gastrointestinal oxalate transport can impact the amount of oxalate excreted by the kidney. Hyperoxaluria is a major risk factor in the formation of kidney stones, and oxalate is derived from both the diet and the liver metabolism of glyoxylate. Although the intestine generally absorbs oxalate from dietary sources and can contribute as much as 50% of urinary oxalate, enteric oxalate elimination plays a significant role when renal function is compromised. While the mechanistic basis for these changes in the direction of intestinal oxalate movements in chronic renal failure involves an upregulation of angiotensin II receptors in the large intestine, enteric secretion/excretion of oxalate can also occur by mechanisms that are independent of angiotensin II. Most notably, the commensal bacterium Oxalobacter sp. interacts with the host enterocyte and promotes the movement of oxalate from the blood into the lumen, resulting in the beneficial effect of significantly lowering urinary oxalate excretion. Changes in the passive permeability of the intestine, such as in steatorrhoea and following gastric bypass, also promote oxalate absorption and hyperoxaluria. In summary, this report highlights the two-way physiological signalling between the gut and the kidney, which may help to alleviate the consequences of certain kidney diseases.
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, FL, 32610, USA hatchma@ufl.edu.
authors.forename: Marguerite
authors.initials: M
authors.lastname: Hatch
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D015390:Gastric Bypass; D006801:Humans; D006959:Hyperoxaluria / Q000378:metabolism / Q000503:physiopathology; D007408:Intestinal Absorption; D066237:Intestinal Elimination; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007669:Kidney Calculi / Q000378:metabolism / Q000503:physiopathology; D019815:Oxalic Acid / Q000378:metabolism* / Q000652:urine; D010539:Permeability; D065667:Renal Elimination; D051436:Renal Insufficiency, Chronic / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D019815:Oxalic Acid