title: Sequestered fulvinol-related polyacetylenes in Peltodoris atromaculata.
abstract: The Mediterranean dorid nudibranch Peltodoris atromaculata that had been collected while feeding on Haliclona fulva was shown to sequester long-chain fulvinol-like polyacetylene metabolites (compounds 2-5) from the prey. They were isolated along with previously reported bromorenierins from the diethyl ether extracts of both the mollusk and the sponge. Their structures were elucidated by NMR spectroscopy and tandem FABMS analysis. Compound 5 exhibited in vitro growth inhibitory effects against the SKMEL-28 melanoma cell line.
authors.affiliation: Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB) , Via Campi Flegrei, 34, 80078 Pozzuoli, Naples, Italy.
authors.forename: M Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Nuzzo
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takada
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Guido
authors.initials: G
authors.lastname: Villani
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D049851:Gastropoda / Q000737:chemistry*; D047129:Haliclona / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D053279:Polyynes