title: Establishment and maintenance of a standardized glioma tissue bank: Huashan experience.
abstract: Cerebral glioma is the most common brain tumor as well as one of the top ten malignant tumors in human beings. In spite of the great progress on chemotherapy and radiotherapy as well as the surgery strategies during the past decades, the mortality and morbidity are still high. One of the major challenges is to explore the pathogenesis and invasion of glioma at various "omics" levels (such as proteomics or genomics) and the clinical implications of biomarkers for diagnosis, prognosis or treatment of glioma patients. Establishment of a standardized tissue bank with high quality biospecimens annotated with clinical information is pivotal to the solution of these questions as well as the drug development process and translational research on glioma. Therefore, based on previous experience of tissue banks, standardized protocols for sample collection and storage were developed. We also developed two systems for glioma patient and sample management, a local database for medical records and a local image database for medical images. For future set-up of a regional biobank network in Shanghai, we also founded a centralized database for medical records. Hence we established a standardized glioma tissue bank with sufficient clinical data and medical images in Huashan Hospital. By September, 2013, tissues samples from 1,326 cases were collected. Histological diagnosis revealed that 73 % were astrocytic tumors, 17 % were oligodendroglial tumors, 2 % were oligoastrocytic tumors, 4 % were ependymal tumors and 4 % were other central nervous system neoplasms.
authors.affiliation: Glioma Surgery Division, Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
authors.forename: Abudumijiti
authors.initials: A
authors.lastname: Aibaidula
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Lu
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Wu
authors.forename: He-jian
authors.initials: HJ
authors.lastname: Zou
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Yu-qian
authors.initials: YQ
authors.lastname: Wang
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Qin
authors.forename: Yu
authors.initials: Y
authors.lastname: Yao
authors.forename: Ye
authors.initials: Y
authors.lastname: Gong
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Che
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.forename: Shi-qi
authors.initials: SQ
authors.lastname: Li
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Bao
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Liang-fu
authors.initials: LF
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018070:Biological Specimen Banks / Q000592:standards*; D035843:Biomedical Research / Q000592:standards*; D002648:Child; D002675:Child, Preschool; D002681:China; D016208:Databases, Factual / Q000592:standards; D005260:Female; D005910:Glioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D013048:Specimen Handling; D057170:Translational Research, Biomedical / Q000592:standards; D055815:Young Adult