title: Epigenetic regulation of persistent pain.
abstract: Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.
authors.affiliation: Program in Neuroscience, Department of Neural and Pain Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD. Electronic address: baigliangy@hotmail.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Bai
authors.affiliation: Program in Neuroscience, Department of Neural and Pain Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD.
authors.forename: Ke
authors.initials: K
authors.lastname: Ren
authors.affiliation: Program in Neuroscience, Department of Neural and Pain Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD.
authors.forename: Ronald
authors.initials: R
authors.lastname: Dubner
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D059350:Chronic Pain / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006657:Histones / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009437:Neuralgia / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D057170:Translational Research, Biomedical; D059265:Visceral Pain / Q000235:genetics / Q000378:metabolism
chemical_list: D056572:Histone Deacetylase Inhibitors; D006657:Histones; D022661:RNA, Untranslated