title: Mixed lineage leukemia-septin 5 fusion transcript inde novoadult acute myeloid leukemia with t(11;22)(q23;q11.2): A case report.
abstract: The current report presents a case ofde novoacute myeloid leukemia (AML) in a 32-year-old male. Cytogenetic analysis showed that the karyotype of the bone marrow cells was as follows: 46,XY,t(11;22)(q23;q11.2)[13]/46,X,-Y,+10,t(11;22)(q23;q11.2)[7]/47,XY,+10,t(11;22)(q23;q11.2)[1]/46,XY[1]. Fluorescence in situ hybridization analysis using a mixed lineage leukemia (MLL)-specific probe showed a split in the MLL gene. Reverse transcription polymerase chain reaction (PCR) analysis demonstrated an MLL-septin 5 (SEPT5) fusion transcript in the patient. Nucleotide sequencing analysis of the PCR product confirmed the fusion between the MLL exon 9 and SEPT5 exon 3, and the product was 521 bp in length. The present study reviewed the clinical and molecular features of the AML with an MLL-SEPT5 fusion gene.
authors.affiliation: Department of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.affiliation: Center of Lu Dao-Pei Hematology Neoplasm, He-Bei Yan Da Hospital, Langfang, Hebei 065201, P.R. China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Center of Lu Dao-Pei Hematology Neoplasm, He-Bei Yan Da Hospital, Langfang, Hebei 065201, P.R. China.
authors.forename: Hong Xing
authors.initials: HX
authors.lastname: Liu
authors.affiliation: Department of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Yan Chen
authors.initials: YC
authors.lastname: Li
authors.affiliation: Department of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
authors.forename: Wen Ming
authors.initials: WM
authors.lastname: Chen
keywords: 11q23; acute myeloid leukemia; mixed lineage leukemia; septin; septin 5