title: Efficacy of growth factor in promoting early osseointegration.
abstract: A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.
authors.affiliation: 1  Department of Periodontology, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Hezaimi
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Soo-Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Ardavan
authors.initials: A
authors.lastname: Fateh
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D000077214:Becaplermin; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008334:Mandible / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D016300:Radiography, Bitewing; D011897:Random Allocation; D011994:Recombinant Proteins; D013499:Surface Properties; D013997:Time Factors; D014783:Viscosity; D014945:Wound Healing / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin
keywords: bone regeneration; dental implant; histology; osseointegration; recombinant human platelet-derived growth factor-BB