title: Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars.
abstract: The aim of this study was compare the efficacies of two oral sprays in reducing swelling, pain, and trismus after the extraction of impacted mandibular third molars. This prospective double-blind, randomized, crossover clinical trial included 34 patients with bilateral symmetrically impacted mandibular third molars of similar surgical difficulty. Hyaluronic acid or benzydamine hydrochloride spray was applied (two pumps) to the extraction area, three times daily for 7 days. Swelling was evaluated using a tape measure method, pain with a visual analogue scale (VAS), and trismus by measuring the maximum inter-incisal opening. Assessments were made on the day of surgery and on days 2 and 7 after surgery. Statistically significant differences were detected for the swelling and trismus values between the two treatment groups on the second postoperative day (P=0.002 and P=0.03, respectively). However, there was no statistically significant difference in VAS scores between the two groups. The administration of hyaluronic acid spray was more effective than benzydamine hydrochloride spray in reducing swelling and trismus. Although no evidence of a reduction in pain levels was detected, hyaluronic acid appears to offer a beneficial effect in the management of swelling and trismus during the immediate postoperative period following impacted third molar surgery.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Koray
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Ofluoglu
authors.affiliation: Department of Public Health, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: E A
authors.initials: EA
authors.lastname: Onal
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozgul
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. Electronic address: ersev@istanbul.edu.tr.
authors.forename: H
authors.initials: H
authors.lastname: Ersev
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yaltirik
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Tanyeri
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001591:Benzydamine / Q000008:administration & dosage; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004487:Edema / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008297:Male; D008334:Mandible / Q000601:surgery; D008964:Molar, Third / Q000601:surgery*; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery*; D016896:Treatment Outcome; D014313:Trismus / Q000188:drug therapy* / Q000209:etiology; D055675:Viscosupplements / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D055675:Viscosupplements; D001591:Benzydamine; D006820:Hyaluronic Acid
keywords: benzydamine hydrochloride; hyaluronic acid; impacted third molar; pain; swelling; trismus