title: A comprehensive rehabilitation program improves disease severity in patients with obstructive sleep apnea syndrome: a pilot randomized controlled study.
abstract: BACKGROUND
  Exercise training may improve components of metabolic syndrome and obstructive sleep apnea syndrome (OSAS). The objective of our pilot randomized controlled study was to determine the benefits of a short intensive inpatient individualized exercise training (IET) program in sedentary untreated OSAS patients.
  
  
  METHODS
  Twenty-two sedentary patients with moderate to severe OSAS were randomly assigned either to one-month education activity sessions (n=11; control group) or to inpatient rehabilitation program (n=11), including IET, education activities sessions, and dietary management. Full polysomnography (PSG), OSLER (Oxford Sleep Resistance test), body composition, anthropometric measurements, metabolic syndrome components, and questionnaires were performed at baseline and at study end point.
  
  
  RESULTS
  No changes occurred in the control group in all variables. Compared to controls, participants randomized to the IET group presented a significant decrease in apnea-hypopnea index (AHI) (40.6±19.4 vs. 28.0±19.3; P<0.001), oxygen desaturation index (ODI), and arousal index, which occurred in conjunction with significant decrease in body mass index (BMI), neck circumference, fat mass, fasting glucose, and diastolic blood pressure. Increased sleep latency was found in participants in the IET group with altered values at baseline.
  
  
  CONCLUSIONS
  IET reduced OSAS severity with improvement of metabolic syndrome components with concomitant loss in body fat in sedentary adults. If confirmed on a larger scale, a comprehensive rehabilitation program could constitute an additional or alternative treatment for moderate to severe OSAS patients.
authors.affiliation: Université MONTPELLIER 1 and INSERM, U1046 "Physiology and Experimental Medicine of Heart and Muscle", Montpellier, France; Clinical Physiology, CHU Montpellier, Montpellier, France; Clinique du souffle "La Solane", Avenue des casteillets, 66230 Osseja, France; Department of Neurology, Hôpital Gui de Chauliac, CHU Montpellier, National Reference Network for Orphan Diseases (Narcolepsy), France. Electronic address: m-desplan@chu-montpellier.fr.
authors.forename: M
authors.initials: M
authors.lastname: Desplan
authors.affiliation: Université MONTPELLIER 1 and INSERM, U1046 "Physiology and Experimental Medicine of Heart and Muscle", Montpellier, France; Clinical Physiology, CHU Montpellier, Montpellier, France.
authors.forename: J
authors.initials: J
authors.lastname: Mercier
authors.affiliation: Clinique du souffle "La Solane", Avenue des casteillets, 66230 Osseja, France.
authors.forename: M
authors.initials: M
authors.lastname: Sabaté
authors.affiliation: Université MONTPELLIER 1, Laboratory Epsylon, EA4556 Dynamics of Human Abilities and Health Behaviors, Montpellier F-34000, France.
authors.forename: G
authors.initials: G
authors.lastname: Ninot
authors.affiliation: Université MONTPELLIER 1 and INSERM, U1046 "Physiology and Experimental Medicine of Heart and Muscle", Montpellier, France; Clinical Physiology, CHU Montpellier, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Prefaut
authors.affiliation: Department of Neurology, Hôpital Gui de Chauliac, CHU Montpellier, National Reference Network for Orphan Diseases (Narcolepsy), France; Inserm U1061, Montpellier, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Dauvilliers
mesh_terms: D000328:Adult; D000368:Aged; D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D017286:Polysomnography; D057185:Sedentary Behavior; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000534:rehabilitation* / Q000628:therapy; D016896:Treatment Outcome
keywords: Diet; Individualized exercise training; Metabolic syndrome; Osler; Rehabilitation; Sleep apnea syndrome; Sleepiness