title: Use of hyaluronidase for pharmacokinetic increase in bioavailability of intracutaneously applied substances.
abstract: Endogenous hyaluronidases in the human body have physiological and pathophysiological significance due to their enzymatic activity during the cleavage of hyaluronan. The potential of therapeutic use of testicular and recombinant hyaluronidase has been increasingly acknowledged and developed in recent years. Most relevant in practice is the co-application of hyaluronidase and other active substances in order to enhance their bioavailability within the tissue.
authors.affiliation: Department of Dermatology and Venereology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Wohlrab
authors.forename: David
authors.initials: D
authors.lastname: Wohlrab
authors.forename: Lukas
authors.initials: L
authors.lastname: Wohlrab
authors.forename: Christiane
authors.initials: C
authors.lastname: Wohlrab
authors.forename: Angelika
authors.initials: A
authors.lastname: Wohlrab
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001682:Biological Availability; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010599:Pharmacokinetics; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase