title: 9q33.3, a stress-related chromosome region, contributes to reducing lung squamous cell carcinoma risk.
abstract: Human chromosome 9q33.3 is one of the most important loci for pathophysiological stresses with complex genetic traits. We hypothesized that the common single-nucleotide polymorphisms on this region may affect non-small-cell lung cancer risk.
  
  
  
  We genotyped 43 single-nucleotide polymorphisms that span 13 genes on 9q33.3 in two independent cohorts: the discovery study including 485 cases and 532 controls (North China) and the replicative study including 1063 cases and 1247 controls (South China). Both of the discovery cohort and the replicative cohort were included in the combined study.
  
  
  
  In the discovery study, we identified a potential protective locus rs10118570 in mitogen-activated protein kinase associated protein 1 with a lower population attributable risk under logistical regression adjusted by age, gender, smoking, and drinking status (adjusted odds ratio [OR] 0.26, 95% confidence interval [CI] 0.10-0.71, p = 1.138 × 10 for genotype GG in lung squamous cell carcinoma). This protective quality increased in a dose-dependent manner as genotype GG decreased (ptrend = 9.675 × 10). Replicative and combined studies showed consistent association for this genotype (replicative: adjusted OR 0.36, 95% CI 0.20-0.66, p = 6.109 × 10, ptrend = 7.386 × 10; combined: adjusted OR 0.33, 95% CI 0.18-0.55, p = 1.259 × 10, ptrend = 7.725 × 10).
  
  
  
  We concluded that mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
authors.affiliation: Department of Biochemistry, Key Laboratory of Molecular Diagnosis, Guangdong Medical College, Dongguan, China; Department of Transfusion, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen. Electronic address: qin_xiao_sz@163.com.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: School of Computer Science and Technology, Tianjin University, Tianjin.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Biochemistry, Key Laboratory of Molecular Diagnosis, Guangdong Medical College, Dongguan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Luo
authors.affiliation: Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wenguo
authors.initials: W
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Guo
authors.affiliation: Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.affiliation: Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong; Department of Human Anatomy, Guangzhou Medical University, Guangzhou, China.
authors.forename: Shuilong
authors.initials: S
authors.lastname: Leng
authors.affiliation: Department of Cancer Biology, Cancer Cell Biology Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Center for Clinical Medical Research, Department of Cancer, Shandong Provincial Zibo Central Hospital, Zibo, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Tao
authors.affiliation: Department of Biochemistry, Key Laboratory of Molecular Diagnosis, Guangdong Medical College, Dongguan, China.
authors.forename: Xingyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jingfang
authors.affiliation: Center for Clinical Medical Research, Department of Cancer, Shandong Provincial Zibo Central Hospital, Zibo, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, GA. Electronic address: dli@gru.edu.
authors.forename: Dongpei
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Transfusion, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002681:China; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C493277:MAPKAP1 protein, human