title: Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease.
abstract: Multilevel item response theory models have been increasingly used to analyze the multivariate longitudinal data of mixed types (e.g., continuous and categorical) in clinical studies. To address the possible correlation between multivariate longitudinal measures and time to terminal events (e.g., death and dropout), joint models that consist of a multilevel item response theory submodel and a survival submodel have been previously developed. However, in multisite studies, multiple patients are recruited and treated by the same clinical site. There can be a significant site correlation because of common environmental and socioeconomic status, and similar quality of care within site. In this article, we develop and study several hierarchical joint models with the hazard of terminal events dependent on shared random effects from various levels. We conduct extensive simulation study to evaluate the performance of various models under different scenarios. The proposed hierarchical joint models are applied to the motivating deprenyl and tocopherol antioxidative therapy of Parkinsonism study to investigate the effect of tocopherol in slowing Parkinson's disease progression.
authors.affiliation: Division of Biostatistics, The University of Texas Health Science Center, Houston, 1200 Pressler St, Houston, TX 77030, U.S.A.
authors.forename: Sheng
authors.initials: S
authors.lastname: Luo
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
mesh_terms: D001499:Bayes Theorem; D002986:Clinical Trials as Topic / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008137:Longitudinal Studies; D015233:Models, Statistical; D015337:Multicenter Studies as Topic / Q000379:methods*; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000188:drug therapy*; D012642:Selegiline / Q000627:therapeutic use; D016019:Survival Analysis; D024505:Tocopherols / Q000627:therapeutic use
chemical_list: D012642:Selegiline; D024505:Tocopherols
keywords: MCMC; clinical trial; failure time; item-response theory; latent variable; nested random effects