title: Calcitonin gene- and parathyroid hormone-related peptides in normotensive and preeclamptic pregnancies: a nested case-control study.
abstract: OBJECTIVE
  To identify whether CGRP and PTHrP serve as screening biomarkers for early detection of preeclampsia or even before the development of preeclampsia in early pregnancy.
  
  
  METHODS
  It was a nested case-control study. The subjects were divided into normotensive (controls) and preeclamptic (cases) groups. Serum samples of 132 cases and 132 controls were collected during pregnancy at three different gestational periods and one sample post delivery, from within the cohort of pregnant women reporting to antenatal clinic. Circulating levels of CGRP and PTHrP were analyzed by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Maternal serum concentrations of CGRP and PTHrP increased with the advancement of gestation age in both normotensive and preeclamptic pregnancies but the significantly less increased levels were observed in preeclamptic pregnancies as compared with normotensive pregnancies. In postpartum period level of CGRP significantly falls in both groups although level of PTHrP continues to increase even after delivery. Maternal serum CGRP and PTHrP concentrations were positively correlated with the infant's birth weights.
  
  
  CONCLUSIONS
  Maternal circulating CGRP and PTHrP concentrations were significantly lower in women with preeclampsia, which may contribute to the development of preeclampsia.
authors.affiliation: Department of Pathology, King George's Medical University, Lucknow, 226003, Uttar Pradesh, India.
authors.forename: Sonali
authors.initials: S
authors.lastname: Yadav
authors.forename: Yogendra Singh
authors.initials: YS
authors.lastname: Yadav
authors.forename: Madhu Mati
authors.initials: MM
authors.lastname: Goel
authors.forename: Urmila
authors.initials: U
authors.lastname: Singh
authors.forename: Shankar Madhav
authors.initials: SM
authors.lastname: Natu
authors.forename: Mahendra Pal Singh
authors.initials: MP
authors.lastname: Negi
mesh_terms: D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure; D015992:Body Mass Index; D015740:Calcitonin Gene-Related Peptide / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005865:Gestational Age; D006801:Humans; D044162:Parathyroid Hormone-Related Protein / Q000097:blood / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D049590:Postpartum Period / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy / Q000097:blood*; D011256:Pregnancy Outcome; D012959:Socioeconomic Factors
chemical_list: D044162:Parathyroid Hormone-Related Protein; D015740:Calcitonin Gene-Related Peptide