title: High diagnostic accuracy and reproducibility of fine-needle aspiration cytology for diagnosing salivary gland tumors: cytohistologic correlation in 182 cases.
abstract: OBJECTIVE
  The purpose of this study was to assess the efficacy and reproducibility of the cytologic diagnosis of salivary gland tumors (SGTs) using fine-needle aspiration cytology (FNAC). The study aimed to determine diagnostic accuracy, sensitivity, and specificity and to evaluate the extent of interobserver agreement.
  
  
  METHODS
  We retrospectively evaluated SGTs from the files of the Division of Pathology at the Clinics Hospital of São Paulo and Piracicaba Dental School between 2000 and 2006.
  
  
  RESULTS
  We performed cytohistologic correlation in 182 SGTs. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 94%, 100%, 100%, 100%, and 99%, respectively. The interobserver cytologic reproducibility showed significant statistical concordance (P < .0001).
  
  
  CONCLUSIONS
  FNAC is an effective tool for performing a reliable preoperative diagnosis in SGTs and shows high diagnostic accuracy and consistent interobserver reproducibility. Further FNAC studies analyzing large samples of malignant SGTs and reactive salivary lesions are needed to confirm their accuracy.
authors.affiliation: Department of Oral Diagnosis and Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
authors.forename: Katya Pulido
authors.initials: KP
authors.lastname: Díaz
authors.affiliation: Division of Anatomic Pathology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP), São Paulo, São Paulo, Brazil.
authors.forename: Renê
authors.initials: R
authors.lastname: Gerhard
authors.affiliation: Division of Anatomic Pathology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP), São Paulo, São Paulo, Brazil.
authors.forename: Regina Barros
authors.initials: RB
authors.lastname: Domingues
authors.affiliation: Division of Anatomic Pathology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP), São Paulo, São Paulo, Brazil.
authors.forename: Leandro Liporoni
authors.initials: LL
authors.lastname: Martins
authors.affiliation: Department of Oral Diagnosis and Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Prado Ribeiro
authors.affiliation: Department of Oral Diagnosis and Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
authors.forename: Márcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
authors.affiliation: Division of Anatomic Pathology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP), São Paulo, São Paulo, Brazil.
authors.forename: Paulo Campos
authors.initials: PC
authors.lastname: Carneiro
authors.affiliation: Department of Oral Diagnosis and Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address: pavargas@fop.unicamp.br.
authors.forename: Pablo Agustin
authors.initials: PA
authors.lastname: Vargas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012680:Sensitivity and Specificity