title: [The study of hormonal status in children with gastroesophageal reflux disease].
abstract: The aim of this work is to study the level of some hormones and their role in the pathogenesis of gastroesophagal reflux disease (GERD) in children.
  
  
  METHODS
  40 children with GERD at the age 9 till 17 years of them 17 boys (42.5%) and 23 girls (57.5%) were examined. Content of somatostatin, gastrin, insulin, cortisol in the blood was studied by immunofermental method. Motor function of the sthomach was studied using the apparatus EGC-4M.
  
  
  RESULTS
  The investigations which were performed revealed the fact that children with GERD have different concentration of somatostatin and gastrin depending on their age. In disturbances of interrelations of somatostatin and gastrin impairment of the stomach motility occurs. High level of insulin and cortisol is found in children with GERD. High level of insulin indicates of stimulation of protective and adaptative mechanisms. High level of cortisol intensifies catabolic processes, leads to disturbances of dynamic equilibration of aggressive-protective factors in the gastroduodenal zone.
  
  
  CONCLUSIONS
  The results of our study revealed vital role of hormonal factors in the pathogenesis of GERD in children.
authors.forename: N V
authors.initials: NV
authors.lastname: Butorina
authors.forename: A M
authors.initials: AM
authors.lastname: Zaprudnov
authors.forename: Ia M
authors.initials: IaM
authors.lastname: Vakhrushev
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D005260:Female; D005746:Gastric Emptying; D005764:Gastroesophageal Reflux / Q000097:blood* / Q000503:physiopathology*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D013270:Stomach / Q000503:physiopathology*
chemical_list: D006728:Hormones