title: Effect of combination therapy on cardiovascular risk in the pit miners with hypertension, metabolic syndrome and depression.
abstract: BACKGROUND
  Higher cardiovascular (CV) morbidity and mortality in depressed patient has demonstrated repeatedly.
  
  
  OBJECTIVE
  Determine the degree of occurrence of hypertension, metabolic syndrome (MetS) and depression in the pit miners and the impact of the six-month holistic treatment of all CV risk factors and depression in the overall CV risk in miners with hypertension, MetS and depression.
  
  
  METHODS
  From 492 pit miners was taken smoking status, measured blood pressure, waist circumference and body mass index. Analysis was done using the concentration of sugar in blood, triglycerides, total cholesterol, HDL, LDL cholesterol and determined total CV risk. All respondents filled self-assessment Beck's depression scale. Prevalence MetS hypertension and depression were determined. Group of 67 patients with joint hypertension, MetS and depression that is treated six months with psychotropic and somatotropin medication, was singled out. After six months, the effect of therapy on the risk factors and total CV was assessed.
  
  
  RESULTS
  Among 492 miners 67 (13,61%) of them had hypertension, MetS and depression. After six months treatment, it showed statistically significant reduction in blood pressure (p=0,0001), waist circumference (p=0,0001) ,total (p=0,002), HDL (p=0,007) and LDL cholesterol (p=0,003), smoking (p=0,002), Beck's scale results (p=0,007) and reduction in total CV risk.
  
  
  CONCLUSIONS
  After six month of combine therapy in respondents has led to reduced CV risk and level of all factors, except BMI and triglycerides.
authors.affiliation: Public Health Centre Banovici, Department of Occupational Medicine, Banovici, Bosnia and Herzegovina.
authors.forename: Munevera
authors.initials: M
authors.lastname: Becarevic
authors.affiliation: Internal Diseases Clinic, University and Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Fahir
authors.initials: F
authors.lastname: Barakovic
authors.affiliation: Department for Family Medicine, Public Health Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Olivera
authors.initials: O
authors.lastname: Batic-Mujanovic
authors.affiliation: Department for Family Medicine, Public Health Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Azijada
authors.initials: A
authors.lastname: Beganlic
keywords: cardiovascular risk; depression; hypertension; metabolical syndrome; risk factor