title: A single nucleotide polymorphism in the stromal cell-derived factor 1 gene is associated with coronary heart disease in Chinese patients.
abstract: Coronary heart disease (CHD) is highly prevalent globally and a major cause of mortality. Genetic predisposition is a non-modifiable risk factor associated with CHD. Eighty-four Chinese patients with CHD and 253 healthy Chinese controls without CHD were recruited. Major clinical data were collected, and a single nucleotide polymorphism (SNP) in the stromal cell-derived factor 1 (SDF-1) gene at position 801 (G to A, rs1801157) in the 3'-untranslated region was identified. The correlation between rs1801157 genotypes and CHD was evaluated by a multivariate logistic regression analysis. The allele frequency in the CHD and control groups was in Hardy-Weinberg equilibrium (HWE) (p>0.05). The frequency of the GG genotype in the CHD group (59.5%) was significantly higher than that in the control group (49.8%) (p=0.036). A number of variables, including male sex, age, presence of hypertension, and the levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), uric acid, and total bilirubin, were associated with CHD in a primary univariate analysis. In a multivariable logistic regression analysis, the GG genotype (GG:AA, odds ratio (OR)=2.31, 95% confidence interval (CI)=1.21-5.23), male sex, advanced age (≥60 years), presence of hypertension, LDL-C level≥3.33 mg/dL, HDL-C level<1.03 mg/dL, and TG level≥1.7 mg/dL were independent risk factors for CHD.
authors.affiliation: Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengleii@kmmu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: Intensive Care Unit, People's Hospital of Yuxi City, Yuxi 653100, China. lili580923@kmmu.edu.cn.
authors.forename: Shi-Yan
authors.initials: SY
authors.lastname: Nian
authors.affiliation: Department of Cardiology, People's Hospital of Yuxi City, Yuxi 653100, China. haoyinglu@kmmu.edu.cn.
authors.forename: Ying-Lu
authors.initials: YL
authors.lastname: Hao
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi 653100, China. xwb103196@sina.com.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Xu
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi 653100, China. yedan16@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Ye
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi 653100, China. zxf1027zxf@163.com.
authors.forename: Xing-Feng
authors.initials: XF
authors.lastname: Zhang
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi 653100, China. lidan1224@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. nfyyzhenglei@smu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D054377:Chemokine CXCL12 / Q000235:genetics*; D002681:China; D003327:Coronary Disease / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D054377:Chemokine CXCL12