title: Polyethylene glycols and organ protection against I/R injury.
abstract: During the organ transplantation process, conservation solutions must address responses to the physiologic organ preservation and prevent ischemia-reperfusion injuries. The use of colloids seems beneficial especially for long ischemia time compared to the impermeant molecules used for short time. The colloids family includes molecules as hydroxyethyl starch (HES), albumin, dextran or polyethylene glycol (PEG). In this review, the authors describe the rational for PEG use, its potential immunomodulatory effect and the main results of its experimental and clinical use.
authors.affiliation: Inserm U1082, 86000 Poitiers, France ; université de Poitiers, faculté de Médecine et de Pharmacie, 86000 Poitiers, France; Service de Biochimie, CHU de Poitiers, 86000 Poitiers, France. Electronic address: sebastien.giraud@chu-poitiers.fr.
authors.forename: S
authors.initials: S
authors.lastname: Giraud
authors.affiliation: Inserm U1082, 86000 Poitiers, France ; université de Poitiers, faculté de Médecine et de Pharmacie, 86000 Poitiers, France; Service d'Urologie, CHU Edouard Herriot, université de Lyon, 69000 Lyon, France.
authors.forename: R
authors.initials: R
authors.lastname: Codas
authors.affiliation: Inserm U1082, 86000 Poitiers, France ; université de Poitiers, faculté de Médecine et de Pharmacie, 86000 Poitiers, France; Service de Biochimie, CHU de Poitiers, 86000 Poitiers, France.
authors.forename: T
authors.initials: T
authors.lastname: Hauet
authors.affiliation: Inserm U1082, 86000 Poitiers, France ; université de Poitiers, faculté de Médecine et de Pharmacie, 86000 Poitiers, France; Service Explorations fonctionnelles, CHU de Poitiers, 86000 Poitiers, France.
authors.forename: M
authors.initials: M
authors.lastname: Eugene
authors.affiliation: Inserm U1082, 86000 Poitiers, France ; université de Poitiers, faculté de Médecine et de Pharmacie, 86000 Poitiers, France; Service d'Urologie, CHU Edouard Herriot, université de Lyon, 69000 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Badet
mesh_terms: D006801:Humans; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation; D019188:Organ Preservation Solutions / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000276:immunology / Q000517:prevention & control*
chemical_list: D019188:Organ Preservation Solutions; D011092:Polyethylene Glycols
keywords: Immunomodulation; Ischémie-reperfusion; Polyethylène glycol; Preservation solution; Solution de preservation; ischemia-Reperfusion injuries; polyethylene glycol