title: Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer.
abstract: The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 breast cancer patients enrolled between January 2000 and December 2010. The expression levels of ERα, ERβ and Her-2 were determined by immunohistochemistry. The differences in expression and molecular subtype distribution between Uygur and Han patients with breast cancer were analyzed using a Pearson's χ2test. Statistically significant differences were observed in the expression levels of ERβ, ERα and Her-2 between the Uygur and Han patients with breast cancer (P<0.05). The expression levels of ERβ (++), ERβ (+++) and Her-2 (+++) in Uygur patients were significantly higher, while the expression levels of ERα (+++) in Uygur patients were significantly lower when compared with Han patients. The percentage of luminal A type breast cancer in Uygur patients was significantly lower when compared with the Han patients, whereas the percentages of basal-like and Her-2 overexpression types were significantly higher than those in Han patients (P<0.05). Therefore, expression levels of ERβ, ERα and Her-2, and molecular subtypes of breast cancer were significantly different between the Uygur and Han populations.
authors.affiliation: Department of Breast Cancer, Digestive and Vascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China.
authors.forename: Liying
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Breast Cancer, Digestive and Vascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Breast Cancer, Digestive and Vascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China.
authors.forename: Yilamu
authors.initials: Y
authors.lastname: Dilimina
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xingjiang 830054, P.R. China.
authors.forename: Bowei
authors.initials: B
authors.lastname: Wang
keywords: breast cancer; estrogen receptor α; estrogen receptor β; ethnicity; human epidermal growth factor receptor-2; molecular subtypes