title: The fetal safety of statins: a systematic review and meta-analysis.
abstract: Although an initial case series suggested that use of statins in pregnancy carried teratogenic risk, a recent meta-analysis of controlled observational studies has failed to corroborate this. A large number of potentially beneficial uses of statins in pregnant women have prompted a new evaluation of the risk-benefit ratio of these agents in pregnancy.
authors.affiliation: The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto ON.
authors.forename: Judith
authors.initials: J
authors.lastname: Zarek
authors.affiliation: The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto ON.
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D011247:Pregnancy
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: cholesterol; congenital malformations; pregnancy; statins