title: Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers.
abstract: An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self-assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.
authors.affiliation: Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323 (USA) http://percec02.chem.upenn.edu/
authors.forename: Shaodong
authors.initials: S
authors.lastname: Zhang
authors.forename: Ralph-Olivier
authors.initials: RO
authors.lastname: Moussodia
authors.forename: Hao-Jan
authors.initials: HJ
authors.lastname: Sun
authors.forename: Pawaret
authors.initials: P
authors.lastname: Leowanawat
authors.forename: Adam
authors.initials: A
authors.lastname: Muncan
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Nusbaum
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Chelling
authors.forename: Paul A
authors.initials: PA
authors.lastname: Heiney
authors.forename: Michael L
authors.initials: ML
authors.lastname: Klein
authors.forename: Sabine
authors.initials: S
authors.lastname: André
authors.forename: René
authors.initials: R
authors.lastname: Roy
authors.forename: Hans-J
authors.initials: HJ
authors.lastname: Gabius
authors.forename: Virgil
authors.initials: V
authors.lastname: Percec
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D037102:Lectins / Q000737:chemistry; D008024:Ligands; D050997:Nanomedicine; D011134:Polysaccharides / Q000737:chemistry*; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D050091:Dendrimers; D037102:Lectins; D008024:Ligands; D011134:Polysaccharides; D053835:Unilamellar Liposomes
keywords: agglutinins; biomembrane glycans; dendrimers; lectins; vesicles