title: Highly selective turn-on fluorescent sensor for nanomolar detection of biologically important Zn2+ based on isonicotinohydrazide derivative: application in cellular imaging.
abstract: A new Zn(2+) selective chemosensor (3) was synthesized by condensation of commercially available substituted salicylaldehyde and isonicotinohydrazide, and characterized by single crystal X-ray crystallography. Receptor 3 with Zn(2+) exhibited a highly selective and pronounced enhancement in the fluorescence emission among different cations by forming a 2:1 complex. The receptor can detect Zn(2+) up to nanomolar level (6.75 nM) with good tolerance of other metal ions and can be used for in vitro cellular imaging.
authors.affiliation: School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, Maharashtra, India.
authors.forename: Kundan
authors.initials: K
authors.lastname: Tayade
authors.affiliation: Department of Applied Chemistry, SV National Institute Technology, Surat, Gujrat, India.
authors.forename: Suban K
authors.initials: SK
authors.lastname: Sahoo
authors.affiliation: Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India.
authors.forename: Banashree
authors.initials: B
authors.lastname: Bondhopadhyay
authors.affiliation: Department of Chemistry, Indian Institute Technology, Ropar 140001, Punjab, India.
authors.forename: Vimal K
authors.initials: VK
authors.lastname: Bhardwaj
authors.affiliation: Department of Chemistry, Indian Institute Technology, Ropar 140001, Punjab, India.
authors.forename: Narinder
authors.initials: N
authors.lastname: Singh
authors.affiliation: Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Basu
authors.affiliation: School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, Maharashtra, India. Electronic address: bendrers@rediffmail.com.
authors.forename: Ratnamala
authors.initials: R
authors.lastname: Bendre
authors.affiliation: School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, Maharashtra, India. Electronic address: kuwaras@gmail.com.
authors.forename: Anil
authors.initials: A
authors.lastname: Kuwar
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002413:Cations, Divalent / Q000032:analysis; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007538:Isoniazid / Q000031:analogs & derivatives*; D008856:Microscopy, Fluorescence / Q000379:methods; D061848:Optical Imaging / Q000379:methods*; D015032:Zinc / Q000032:analysis*
chemical_list: D000447:Aldehydes; D002413:Cations, Divalent; D005456:Fluorescent Dyes; C013243:salicylaldehyde; D015032:Zinc; D007538:Isoniazid
keywords: Cellular imaging; Fluorescent sensor; Nanomolar detection; Zn(2+) detection