title: Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article.
abstract: Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovasculardeaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysmformation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin hasbeen shown to be increased in aneurysm tissue and expression of plasmin, membrane-type matrix metalloproteinase-1(MT1-MMP), and matrix metalloproteinase-2 (MMP-2) in aneurysmal wall is more than what we observein normal cerebral arteries. MMP inhibitors such as doxycycline and statins may prohibit aneurysm formationand growth. MMPs are important in tissue remodeling associated with various physiological and pathologicalprocesses such as morphogenesis, angiogenesis, apoptosis and tissue repair. In this article we review therole of MMPs and MMP inhibitors in formation of aneurysm.
authors.affiliation: General practitioner, Brain and spinal injury repair research center (BASIR), Tehran University of Medical Sciences, Tehran, Iran. azam.mardani@yahoo.com.
authors.forename: Azam
authors.initials: A
authors.lastname: Maradni
authors.affiliation: Assistant Professor, Department of Neurosurgery, Brain and spinal injury repair research center, Tehran University of medical sciences, Tehran, Iran. akhoshnevisan@tums.ac.ir.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khoshnevisan
authors.affiliation: Assistant of Surgery, Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran. shm135978@yahoo.com.
authors.forename: Seyed Hamzeh
authors.initials: SH
authors.lastname: Mousavi
authors.affiliation: Professor, Department of Surgery, Brain and spinal injury repair research center (BASIR), Tehran University of Medical Sciences, Tehran, Iran. emami_r@health.gov.ir.
authors.forename: Seyed Hasan
authors.initials: SH
authors.lastname: Emamirazavi
authors.affiliation: Assistant Professor, Brain and spinal injury repair research center, Tehran University of Medical Sciences, Tehran, Iran. noroozi@tums.ac.ir.
authors.forename: Abbas
authors.initials: A
authors.lastname: Noruzijavidan
keywords: Cerebral aneurysm; Doxycycline; MMP inhibitors; MMPs; Statins