title: A novel highly sensitive and selective fluorescent sensor for imaging copper (II) in living cells.
abstract: In this work, we designed and synthesized a novel quinolin-based derivative which exhibited signaling behaviors for Cu(2+). Upon the addition of Cu(2+) to the solution of the molecule, it displayed an obvious fluorescence quenching in a linear fashion due to the formation of a 1:1 metal-ligand complex. This fluorescent sensor exhibited a rare sensitivity toward Cu(II) (the level of magnitude could be 6 × 10(-8)), a rapid response (<10 s) and also high selectivity toward Cu(2+) over other metal ions such as Na(+), K(+), Ca(2+), Mg(2+), Ba(2+), Fe(3+), Mn(2+), Hg(2+), Pb(2+), Cd(2+), Cr(3+), Co(2+), Zn(2+) and Al(3+). Simultaneously, the cell imaging experiments and filter paper test demonstrated its extensive applicability.
authors.affiliation: Department of Chemistry, Jilin University, Changchun, 130021, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Ning
authors.initials: N
authors.lastname: Xiao
authors.forename: Yapeng
authors.initials: Y
authors.lastname: Li
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Xu
mesh_terms: D002470:Cell Survival; D003300:Copper / Q000032:analysis*; D005456:Fluorescent Dyes / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D003300:Copper