title: Magnetic solid sulfonic acid decorated with hydrophobic regulators: a combinatorial and magnetically separable catalyst for the synthesis of α-aminonitriles.
abstract: A three-component, Strecker reaction of a series of aldehydes or ketones, amines, and trimethylsilyl cyanide for the synthesis of α-aminonitriles in the presence of a catalytic amount of a magnetic solid sulfonic acid catalyst, Fe3O4@SiO2@Me&Et-PhSO3H under solvent-free conditions have been investigated. This catalyst, with a combination of hydrophobicity and acidity on the Fe3O4@SiO2 core-shell of the magnetic nanobeads, as well as its water-resistant property, enabled easy mass transfer and catalytic activity in the Strecker reaction. The catalyst was easily separated by an external magnet and the recovered catalyst was reused in 6 successive reaction cycles without any significant loss of activity.
authors.affiliation: Department of Chemistry, K. N. Toosi University of Technology , P.O. Box 16315-1618, Tehran, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Mobaraki
authors.forename: Barahman
authors.initials: B
authors.lastname: Movassagh
authors.forename: Babak
authors.initials: B
authors.lastname: Karimi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007659:Ketones / Q000737:chemistry; D060328:Magnetic Phenomena; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D003486:Cyanides; D007659:Ketones; D009570:Nitriles; D009942:Organometallic Compounds; D013451:Sulfonic Acids; D014297:Trimethylsilyl Compounds; C058010:trimethylsilyl cyanide