title: Epidemiology of hemoglobinopathies and thalassemias in individuals referred to the haematology research centre, Shiraz University of Medical Sciences, Shiraz, Iran from 2006 to 2011.
abstract: Hemoglobinopathies and thalassemias are the most frequent genetic hereditary disorders with an increasing global health burden, especially in low- and middle-income countries. We aimed to determine the epidemiologic pattern of hemoglobinopathies and thalassemias in individuals referred to the Haematology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran, which is the most important referral center in Southern Iran during 2006 to 2011. The most frequent abnormality was β-thalassemia (β-thal) minor (24.0%), followed by α-thalassemia (α-thal) trait (10.0%), hemoglobin (Hb) S trait (4.0%) and Hb D-Punjab trait (4.0%). Because this center is a referral center, we detected a higher prevalence compared to the normal population; however, these data could help policymakers and health service providers to better programming for prevention of births affected with Hb disorders.
authors.affiliation: Haematology Research Centre, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Sezaneh
authors.initials: S
authors.lastname: Haghpanah
authors.forename: Mani
authors.initials: M
authors.lastname: Ramzi
authors.forename: Maryam
authors.initials: M
authors.lastname: Zakerinia
authors.forename: Habib
authors.initials: H
authors.lastname: Nourani Khojasteh
authors.forename: Mansour
authors.initials: M
authors.lastname: Haghshenas
authors.forename: Narges
authors.initials: N
authors.lastname: Rezaei
authors.forename: Vida
authors.initials: V
authors.lastname: Moayed
authors.forename: Alireza
authors.initials: A
authors.lastname: Rezaei
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003430:Cross-Sectional Studies; D006453:Hemoglobinopathies / Q000453:epidemiology* / Q000266:history; D049674:History, 21st Century; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D013789:Thalassemia / Q000453:epidemiology* / Q000266:history; D055815:Young Adult
keywords: Epidemiology; hemoglobinopathies; thalassemias