title: ⁶⁸Ge content quality control of ⁶⁸Ge/⁶⁸Ga-generator eluates and ⁶⁸Ga radiopharmaceuticals--a protocol for determining the ⁶⁸Ge content using thin-layer chromatography.
abstract: (68)Ge breakthrough from a (68)Ge/(68)Ga-generator appears to be one of the most critical parameters for the routine clinical application of this generator and (68)Ga-radiopharmaceuticals. We report a TLC-based (thin-layer chromatography) protocol which allows the (68)Ge breakthrough of a generator to be determined within 1 h post-initial elution. The protocol can also be adapted to allow the (68)Ge content of a (68)Ga-radiopharmaceutical preparation to be determined prior to in vivo application.
authors.affiliation: Institute of Nuclear Chemistry, University of Mainz, D-55128 Mainz, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Eppard
authors.affiliation: Institute of Nuclear Chemistry, University of Mainz, D-55128 Mainz, Germany.
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Loktionova
authors.affiliation: Institute of Nuclear Chemistry, University of Mainz, D-55128 Mainz, Germany. Electronic address: frank.roesch@uni-mainz.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Rösch
mesh_terms: D002855:Chromatography, Thin Layer / Q000379:methods*; D005710:Gallium Radioisotopes / Q000737:chemistry*; D005857:Germanium / Q000032:analysis / Q000737:chemistry*; D016014:Linear Models; D011786:Quality Control; D011868:Radioisotopes / Q000032:analysis / Q000737:chemistry*; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000737:chemistry*
chemical_list: D005710:Gallium Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D005857:Germanium
keywords: (68)Ge/(68)Ga-generator; Breakthrough; Ga-68-DOTATOC; Ga-68-radiopharmaceutical; Separation; TLC