title: Levels of oestrogen receptor, progesterone receptor and αB-crystallin in eutopic endometrium in relation to pregnancy in women with endometriosis.
abstract: Endometriosis affects fertility in many women and may partly be due to decreased endometrial receptivity. Several mechanisms have been suggested, notably, progesterone resistance for which a number of candidate biomarkers have been suggested. Here we demonstrate aberrant levels of steroid hormone receptors and the small heat shock protein αB-crystallin in eutopic endometrial epithelium from 38 women with peritoneal endometriosis diagnosed during investigation for secondary infertility. Spontaneous pregnancies within 1 year after medical and surgical treatment for endometriosis were recorded and semi-quantitative immunohistochemistry data compared between women with endometriosis who did or did not become pregnant and healthy controls. Stronger immunostaining for ER-α was detected in luminal and glandular endometrial epithelium from women with endometriosis who did not become pregnant during the post-treatment observation period versus endometriosis patients who became pregnant and controls. Staining levels of PR and PR-B were lower in patients without subsequent pregnancies than in the two other groups. Endometrial levels of αB-crystallin in endometriosis patients similar to those in controls were strongly correlated with the chance of becoming pregnant, whereas higher or lower levels were not.
authors.affiliation: Department of Women's and Children's Health, Uppsala University , Uppsala , Sweden.
authors.forename: Christian
authors.initials: C
authors.lastname: Moberg
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bourlev
authors.forename: Natalia
authors.initials: N
authors.lastname: Ilyasova
authors.forename: Matts
authors.initials: M
authors.lastname: Olovsson
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D010532:Peritoneal Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000378:metabolism*; D012720:Severity of Illness Index; D038203:alpha-Crystallin B Chain / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C059215:CRYAB protein, human; C506487:ESR1 protein, human; C000600034:ESR2 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011980:Receptors, Progesterone; D038203:alpha-Crystallin B Chain
keywords: Endometriosis; oestrogen receptor; pregnancy; progesterone receptor; αB-crystallin