title: Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study.
abstract: OBJECTIVE
  Compared with western populations, the consumption of soy foods among Japanese is very high and the incidence of endometrial cancer very low. We evaluated the association of soy food and isoflavone intake with endometrial cancer risk in Japanese women.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Ten public health centre areas in Japan.
  
  
  METHODS
  Forty nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey questionnaire.
  
  
  METHODS
  Intakes of soy foods as well as other covariates were assessed in 1995-1998 by a self-administered food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).
  
  
  METHODS
  Incidence of endometrial cancer.
  
  
  RESULTS
  During an average of 12.1 years of follow up, 112 newly diagnosed endometrial cancer cases were identified. Energy-adjusted intakes of soy food and isoflavone were not associated with the risk of endometrial cancer. The multivariate-adjusted HR per 25 g/day increase in the intake of soy food was 1.02 (95% CI 0.94-1.10), and the corresponding value for isoflavone intake per 15 mg/day was 1.01 (95% CI 0.84-1.22).
  
  
  CONCLUSIONS
  In this population-based prospective cohort study of Japanese women, we observed no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk.
authors.affiliation: Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Budhathoki
authors.forename: M
authors.initials: M
authors.lastname: Iwasaki
authors.forename: N
authors.initials: N
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Yamaji
authors.forename: T
authors.initials: T
authors.lastname: Shimazu
authors.forename: S
authors.initials: S
authors.lastname: Sasazuki
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000368:Aged; D015992:Body Mass Index; D004034:Diet Surveys; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007529:Isoflavones / Q000009:adverse effects; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D048789:Phytoestrogens / Q000009:adverse effects; D011159:Population Surveillance; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011634:Public Health; D012307:Risk Factors; D045730:Soy Foods / Q000009:adverse effects; D013025:Glycine max; D011795:Surveys and Questionnaires
chemical_list: D007529:Isoflavones; D048789:Phytoestrogens
keywords: Endometrial cancer risk; epidemiology; isoflavone; prospective study; soy food