title: A new pathological scoring method for adrenal injury in rats with severe acute pancreatitis.
abstract: These studies investigated the appearance and function of adrenal glands in rats with severe acute pancreatitis (SAP) and established a new histopathological score to evaluate adrenal histopathological changes. Severe acute pancreatitis relied on retrograde infusion of 5% sodium taurocholate into the bile-pancreatic duct. The damage of SAP was estimated by serum amylase, secretory phospholipase A2 and pancreatic histopathology. Light and electron microscopy of adrenal gland, and the levels of serum corticosterone were investigated. These results showed that the generally ascending trend of adrenal pathological score was inversely proportional to the generally descending trend of serum corticosterone levels, but parallel with the changes of pancreatic histopathology. Herein, the new adrenal histopathological score was effective in the evaluation of adrenal injury following SAP. It may indirectly reflect the variation of serum cortisol levels and the severity of pancreatitis to a certain extent.
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, 430060, Hubei Province, People's Republic of China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Taihe Hospital of Hubei Medical University, Shiyan 442000, Hubei Province, People's Republic of China.
authors.forename: Yuanjian
authors.initials: Y
authors.lastname: Hui
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, 430060, Hubei Province, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, 430060, Hubei Province, People's Republic of China. Electronic address: sate.llite@163.com.
authors.forename: Weixing
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of General Surgery, People's Hospital of Guangxi Zhuang Autonomous Region, 530021, Nanning Province, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, 430060, Hubei Province, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, 430060, Hubei Province, People's Republic of China.
authors.forename: Xincheng
authors.initials: X
authors.lastname: Xiong
mesh_terms: D000311:Adrenal Glands / Q000473:pathology*; D000681:Amylases / Q000097:blood; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000097:blood / Q000473:pathology*; D054497:Phospholipases A2, Secretory / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012107:Research Design; D012720:Severity of Illness Index
chemical_list: D054497:Phospholipases A2, Secretory; D000681:Amylases
keywords: Acute pancreatitis; Adrenal glands; Corticosterone level; Pathological Scoring