title: Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.
abstract: Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.
authors.affiliation: Inserm, U991, université de Rennes 1, 35000 Rennes, France. Electronic address: bernard.fromenty@inserm.fr.
authors.forename: B
authors.initials: B
authors.lastname: Fromenty
mesh_terms: D019297:2,4-Dinitrophenol / Q000627:therapeutic use*; D000818:Animals; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy* / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats; D014475:Uncoupling Agents / Q000627:therapeutic use*
chemical_list: D014475:Uncoupling Agents; D019297:2,4-Dinitrophenol