title: Clinical characteristics of craniomaxillofacial fibrous dysplasia.
abstract: BACKGROUND
  The clinical characteristics of craniomaxillofacial fibrous dysplasia (FD) have not been clearly identified. The objective of this meta-analysis is to assess the predominance of the monostotic form of FD using an evidence-based review. Furthermore, we examined the laterality and sex dominance of FD in patients from international study populations.
  
  
  METHODS
  We performed a systematic search of PubMed, Embase, Cochrane Central Register of Systematic Reviews, Cochrane Central Register of Controlled Trials and EBSCO for trials published through August 2013. Data extracted from the literature were analysed with Review manager 5.0.24.
  
  
  RESULTS
  The results of this study showed that unilateral FD occurred more frequently than bilateral FD (RR, 12.37; 95% CI, 2.92-61.24; P = 0.008, N = 263 patients). For unilateral FD, there was no significant difference between cases involving the left or right side of the face (RR, 0.98; 95% CI, 0.66-1.44; P = 0.91; N = 201 patients). There were no significant sex-dependent differences for monostotic and polyostotic forms of craniomaxillofacial FD.
  
  
  CONCLUSIONS
  There is a significantly higher percentage of the unilateral form than the bilateral form in the craniomaxillofacial FD studies analysed, and an almost equal distribution of left- and right-sided unilateral FD. These proportions were maintained among males and females and there were nearly equal frequencies of monostotic and polyostotic FD.
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Wu
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Liya
authors.initials: L
authors.lastname: Yang
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Li
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Jin
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Jiajie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Jianjian
authors.initials: J
authors.lastname: Lu
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Cranio-maxillo-facial Surgery Department 2, Plastic Surgery Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China. Electronic address: zhengxingwuke@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Teng
mesh_terms: D005147:Facial Bones / Q000473:pathology*; D005260:Female; D005358:Fibrous Dysplasia, Monostotic / Q000175:diagnosis*; D005359:Fibrous Dysplasia, Polyostotic / Q000175:diagnosis*; D006801:Humans; D008297:Male; D012737:Sex Factors; D012886:Skull / Q000473:pathology*
keywords: Clinical characteristics; Craniomaxillofacial fibrous dysplasia; Meta-analysis