title: Transcranial Doppler to assess sepsis-associated encephalopathy in critically ill patients.
abstract: BACKGROUND
  Transcranial Doppler can detect cerebral perfusion alteration in septic patients. We correlate static Transcranial Doppler findings with clinical signs of sepsis-associated encephalopathy.
  
  
  METHODS
  Forty septic patients were examined with Transcranial Doppler on the first and third day of sepsis diagnosis. The pulsatility index (PI) and cerebral blood flow index (CBFi) were calculated by blood velocity in the middle cerebral artery (cm/sec). Patients underwent a daily cognitive assessment with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) test.
  
  
  RESULTS
  Twenty-one patients (55%) were found to present confusion. The majority of the patients presented a PI > 1.1 (76%). PI on the first day (but not the third day) could predict a positive CAM-ICU test in septic patients (PI cut-off: 1.3, AUC: 0.905, p < 0.01, sensitivity: 95%, specificity: 88%, AUC: 0.618, p = 0.24). Multivariable analysis showed that PI on the first day is related to a positive CAM-ICU test independent of age and APACHE II score (OR: 5.6, 95% CI: 1.1-29, p = 0.03). A decrease of the PI on the third day was observed in the group that presented initially high PI (>1.3) (2.2 ± 0.71 vs. 1.81 ± 0.64; p = 0.02). On the other hand, an increase in PI was observed in the other patients (1.01 ± 0.15 vs. 1.58 ± 0.57; p < 0.01). On only the first day, the mean blood velocity in the middle cerebral artery and CBFi were found to be lower in those patients with a high initial PI (36 ± 21 vs. 62 ± 28 cm/sec; p < 0.01, 328 ± 101 vs. 581 ± 108; p < 0.01, respectively).
  
  
  CONCLUSIONS
  Cerebral perfusion disturbance observed with Transcranial Doppler could explain clinical symptoms of sepsis-associated encephalopathy.
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Pierrakos
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: Rachid
authors.initials: R
authors.lastname: Attou
authors.affiliation: Departments of Geriatrics, Brugmann University Hospital, Université Libre de Bruxelles, Bruxelles, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Decorte
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kolyviras
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: Stefano
authors.initials: S
authors.lastname: Malinverni
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gottignies
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: Jacques
authors.initials: J
authors.lastname: Devriendt
authors.affiliation: Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Place Van Gehuchten 4, 1020 Bruxelles, Belgium.
authors.forename: David
authors.initials: D
authors.lastname: De Bels
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D003221:Confusion / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D016638:Critical Illness; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D015999:Multivariate Analysis; D011446:Prospective Studies; D065166:Sepsis-Associated Encephalopathy / Q000000981:diagnostic imaging*; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*