title: Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.
abstract: Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identification of novel genetic regulators.
authors.affiliation: Department of Pathology, University of Utah Salt Lake City, UT, USA.
authors.forename: Kenneth K C
authors.initials: KK
authors.lastname: Bramwell
authors.affiliation: Department of Medicine, University of Vermont Burlington, VT, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Teuscher
authors.affiliation: Department of Pathology, University of Utah Salt Lake City, UT, USA.
authors.forename: Janis J
authors.initials: JJ
authors.lastname: Weis
mesh_terms: D000818:Animals; D025065:Borrelia burgdorferi / Q000276:immunology*; D004198:Disease Susceptibility; D006801:Humans; D008193:Lyme Disease / Q000235:genetics* / Q000473:pathology*
keywords: Lyme arthritis; Lyme disease; beta-Glucuronidase; forward genetics; genome-wide association studies; inflammation; innate immunity and responses; pathogenesis