title: Physical activity in the management of patients with coronary artery disease: a review.
abstract: Cardiovascular diseases remain the leading cause of death in the Western world despite advances in therapeutics and interventions. The prescription of physical activity is a key component of cardiac rehabilitation following myocardial infarction. This review aims to outline the impact of physical activity in particular patient cohorts with coronary artery disease. The current understanding of the mechanisms involved in atherosclerosis, plaque rupture and thrombosis, and how these can be modified by physical activity, are also discussed. There is the potential for future research to investigate the clinical and mechanistic effects of different exercise types, intensities, duration, and frequencies in patients hospitalized for coronary artery disease.
authors.affiliation: From the *Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, United Kingdom; †Institute for Ageing and Health, Newcastle University, United Kingdom; and ‡Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom.
authors.forename: James
authors.initials: J
authors.lastname: Backshall
authors.forename: Gary A
authors.initials: GA
authors.lastname: Ford
authors.forename: Bilal
authors.initials: B
authors.lastname: Bawamia
authors.forename: Louise
authors.initials: L
authors.lastname: Quinn
authors.forename: Mike
authors.initials: M
authors.lastname: Trenell
authors.forename: Vijay
authors.initials: V
authors.lastname: Kunadian
mesh_terms: D000367:Age Factors; D000368:Aged; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy*; D003863:Depression / Q000150:complications; D019468:Disease Management; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D012307:Risk Factors; D012737:Sex Factors; D016896:Treatment Outcome