title: Natural products as source of potential dengue antivirals.
abstract: Dengue is a neglected disease responsible for 22,000 deaths each year in areas where it is endemic. To date, there is no clinically approved dengue vaccine or antiviral for human beings, even though there have been great efforts to accomplish these goals. Several approaches have been used in the search for dengue antivirals such as screening of compounds against dengue virus enzymes and structure-based computational discovery. During the last decades, researchers have turned their attention to nature, trying to identify compounds that can be used as dengue antivirals. Nature represents a vast reservoir of substances that can be explored with the aim of discovering new leads that can be either used directly as pharmaceuticals or can serve as lead structures that can be optimized towards the development of new antiviral agents against dengue. In this review we describe an assortment of natural products that have been reported as possessing dengue antiviral activity. The natural products are organized into classes of substances. When appropriate, structure-activity relationships are outlined. The biological assays used to assess antiviral activity are briefly described.
authors.affiliation: Departamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil. robsonr.teixeira@ufv.br.
authors.forename: Róbson Ricardo
authors.initials: RR
authors.lastname: Teixeira
authors.affiliation: Departamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
authors.forename: Wagner Luiz
authors.initials: WL
authors.lastname: Pereira
authors.affiliation: Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil.
authors.forename: Ana Flávia Costa da Silveira
authors.initials: AF
authors.lastname: Oliveira
authors.affiliation: Departamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
authors.forename: Adalberto Manoel
authors.initials: AM
authors.lastname: da Silva
authors.affiliation: Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil.
authors.forename: André Silva
authors.initials: AS
authors.lastname: de Oliveira
authors.affiliation: Departamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
authors.forename: Milene Lopes
authors.initials: ML
authors.lastname: da Silva
authors.affiliation: Departamento de Microbiologia, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.
authors.forename: Cynthia Cânedo
authors.initials: CC
authors.lastname: da Silva
authors.affiliation: Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil. depaula@ufv.br.
authors.forename: Sérgio Oliveira
authors.initials: SO
authors.lastname: de Paula
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D003716:Dengue Virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001688:Biological Products