title: Intestinal ischemia after allogeneic stem cell transplantation: a report of four cases.
abstract: Gastrointestinal ischemia after allogeneic bone marrow transplantation is a rare complication not well-described in the literature. Herein we retrospectively review charts of four patients who developed intestinal ischemia after allogeneic bone marrow transplantation at our institution. The patients were found to be predominately younger males who presented with nonspecific abdominal pain. Graft-versus-host disease was a common finding among all patients. Laboratory values suggestive of microangiopathy were present in two patients. Obesity and hypertriglyceridemia were cardiovascular risk factors found in these patients. The development of thrombotic microangiopathy and cardiovascular risk factors after allogeneic bone marrow transplantation may predispose patients to gastrointestinal ischemia and may portend a poor prognosis.
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: L
authors.initials: L
authors.lastname: Prochaska
authors.affiliation: Cardiology and Cardiovascular Research, Mid America Cardiology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: J
authors.initials: J
authors.lastname: Vacek
authors.affiliation: Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: R
authors.initials: R
authors.lastname: Madan
authors.affiliation: Division of Hematology/Oncology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: S
authors.initials: S
authors.lastname: Abhyankar
authors.affiliation: Division of Hematology/Oncology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: S
authors.initials: S
authors.lastname: Ganguly
authors.affiliation: Division of Hematology/Oncology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: J P
authors.initials: JP
authors.lastname: McGuirk
authors.affiliation: Division of Hematology/Oncology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: T L
authors.initials: TL
authors.lastname: Lin
authors.affiliation: Division of Hematology/Oncology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas. Electronic address: oaljitawi@kumc.edu.
authors.forename: O S
authors.initials: OS
authors.lastname: Aljitawi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D055815:Young Adult