title: Fertility-sparing partial hysterectomy for gestational trophoblastic neoplasia: an analysis of 36 cases.
abstract: OBJECTIVE
  To evaluate the success of partial hysterectomy in treating gestational trophoblastic neoplasia (GTN) and preserving fertility.
  
  
  METHODS
  A retrospective review was conducted on 36 patients with GTN who underwent adjuvant fertility-sparing partial hysterectomy at the Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, China, between 1991 and 2008.
  
  
  RESULTS
  Of 36 patients, 34 had fertility-sparing partial hysterectomy; 2 required full hysterectomy due to excessive bleeding during surgery. All women went into remission from their disease. Twenty-five subsequently achieved clinical pregnancy, resulting in a total of 23 live births.
  
  
  CONCLUSIONS
  Partial hysterectomy with chemotherapy can be effective in treating GTN while preserving future fertility. This should be considered as an option for women who wish to pursue pregnancy in the future.
authors.forename: Bei
authors.initials: B
authors.lastname: Cheng
authors.forename: Zhi Xia
authors.initials: ZX
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Jian Hua
authors.initials: JH
authors.lastname: Qian
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002681:China; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D031901:Gestational Trophoblastic Disease / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate