title: Diterpenoids from the Chinese liverwort Heteroscyphus tener and their antiproliferative effects.
abstract: Four new ent-labdane diterpenoids, heteroscyphins A-D (1-4), and four known diterpenoids (5-8) were isolated from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn. The absolute configuration of compound 1 was defined by single-crystal X-ray diffraction using Cu Kα radiation. Cytotoxicity tests revealed that compounds 3 and 5 exhibited modest activity against seven cancer cell lines. Compound 5 showed inhibitory effects on prostate cancer (PCa) cell proliferation but with less inhibition on non-neoplastic prostate epithelial cells. Compound 5 markedly caused cell growth arrest at the G0/G1 phase and induced cellular apoptosis through ROS-mediated DNA damage in PCa cells.
authors.affiliation: Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
authors.forename: Zhao-Min
authors.initials: ZM
authors.lastname: Lin
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Guo
authors.forename: Shu-Qi
authors.initials: SQ
authors.lastname: Wang
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Chang
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.forename: Huiqing
authors.initials: H
authors.lastname: Yuan
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D017382:Reactive Oxygen Species / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D017382:Reactive Oxygen Species; C433017:labdane