title: Snake venom L-amino acid oxidases: an overview on their antitumor effects.
abstract: The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.
authors.affiliation: Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
authors.forename: Tássia R
authors.initials: TR
authors.lastname: Costa
authors.affiliation: Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Burin
authors.affiliation: Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
authors.forename: Danilo L
authors.initials: DL
authors.lastname: Menaldo
authors.affiliation: Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
authors.forename: Fabíola A
authors.initials: FA
authors.lastname: de Castro
authors.affiliation: Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil ; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, B. Monte Alegre, Ribeirão Preto, SP CEP 14040-903, Brasil.
authors.forename: Suely V
authors.initials: SV
authors.lastname: Sampaio
keywords: Antitumor effects; Apoptosis; L-amino acid oxidases; Snake venoms