title: Efficient C(sp3alkyl)-SCF3 bond formations via copper-mediated trifluoromethylthiolation of alkyl halides.
abstract: A general and convenient copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described. Variation of the solvent, additives and time allowed optimization of the reaction. A wide range of alkyl halides were explored to give a set of alkyl trifluoromethyl thioethers in moderate to excellent yields. A variety of functional groups, including ethers, thioether, esters, nitriles, amides, and ketal groups, were well tolerated in the electrophilic partner.
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou 350108, China. zweng@fzu.edu.cn.
authors.forename: Quanfu
authors.initials: Q
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Huang
authors.forename: Mingguang
authors.initials: M
authors.lastname: Rong
authors.forename: Yaofeng
authors.initials: Y
authors.lastname: Yuan
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Weng