title: The microbiota-gut-brain axis in functional gastrointestinal disorders.
abstract: Functional gastrointestinal disorders (FGIDs) are highly prevalent and pose a significant burden on health care and society, and impact patients' quality of life. FGIDs comprise a heterogeneous group of disorders, with unclear underlying pathophysiology. They are considered to result from the interaction of altered gut physiology and psychological factors via the gut-brain axis, where brain and gut symptoms are reciprocally influencing each other's expression. Intestinal microbiota, as a part of the gut-brain axis, plays a central role in FGIDs. Patients with Irritable Bowel Syndrome, a prototype of FGIDs, display altered composition of the gut microbiota compared with healthy controls and benefit, at the gastrointestinal and psychological levels, from the use of probiotics and antibiotics. This review aims to recapitulate the available literature on FGIDs and microbiota-gut-brain axis.
authors.affiliation: Farncombe Family Digestive Health Research Institute; McMaster University; Hamilton, Canada.
authors.forename: Giada
authors.initials: G
authors.lastname: De Palma
authors.affiliation: Farncombe Family Digestive Health Research Institute; McMaster University; Hamilton, Canada.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Collins
authors.affiliation: Farncombe Family Digestive Health Research Institute; McMaster University; Hamilton, Canada.
authors.forename: Premysl
authors.initials: P
authors.lastname: Bercik
mesh_terms: D001921:Brain / Q000502:physiology*; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000502:physiology*; D006801:Humans; D064307:Microbiota; D015995:Prevalence
keywords: IBS; anxiety; depression; functional gastrointestinal disorders; gut-brain axis; microbiota