title: [Correlation of serum adropin level with coronary artery disease].
abstract: OBJECTIVE
  To explore the correlation of serum adropin level with coronary artery disease (CAD).
  
  
  METHODS
  According to coronary angiography, 356 consecutive patients with chest complaints from January 2011 to July 2012 were divided into 2 groups of CAD (n = 264, with CAD) and control (n = 92, without CAD). The serum adropin level and other CAD related metabolic parameters were measured and SYNTAX score was calculated.
  
  
  RESULTS
  Serum adropin level was significantly lower in group CAD than that in control group ((56 ± 15) vs (83 ± 10) ng/L, P < 0.01).Serum adropin levels in high, mild, low SYNTAX score group were (60 ± 22),(56 ± 12),(54 ± 10) ng/L respectively, and there was no significant difference among 3 groups(P = 0.116). Multivariate regression analysis revealed that adropin was an independent risk factor for CAD (OR = 0.849, 95%CI:0.817-0.882, P < 0.01).
  
  
  CONCLUSIONS
  Lower serum adropin level is significantly associated with CAD. Thus it indicates a possible role of adropin in the prevention of CAD.
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
authors.forename: Chengjia
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China. Email: xuwt1968@aliyun.com.
authors.forename: Weiting
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
authors.forename: Jianchang
authors.initials: J
authors.lastname: Chen
mesh_terms: D000368:Aged; D001798:Blood Proteins; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*
chemical_list: D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides