title: High volumetric breast density predicts risk for breast cancer in postmenopausal, but not premenopausal, Korean Women.
abstract: OBJECTIVE
  We investigated the association between mammographic breast density and breast cancer risk in Korean women according to menopausal status and breast cancer subtypes.
  
  
  METHODS
  We enrolled 677 patients diagnosed with breast cancer and 1,307 healthy controls who participated in screening mammography at the National Cancer Center. Breast density was estimated using volumetric breast composition measurement.
  
  
  RESULTS
  Of the total population, 1,156 (58.3 %) women were postmenopausal. The risk of breast cancer increased progressively with the increment of volumetric density grade (VDG) in postmenopausal women (p < 0.001). High breast density (VDG 4) was significantly associated with breast cancer compared with low breast density (VDG 1/2) regardless of body mass index. However, the association with parity and history of hormone replacement therapy (HRT) was only found in those with ≥2 children and those not receiving HRT. Breast density was positively associated with breast cancer risk regardless of histologic grade, tumor size, lymph node involvement, Ki67 index, and hormone receptor status. The association was more prominent in human epidermal growth factor receptor 2 (HER2)-positive tumors (VDG 1/2 vs. VDG 4 for HER2 normal, odds ratio [OR] 2.21, 95 % confidence interval [CI] 1.28-3.83, p < 0.001; for HER2 positive, OR 8.63, 95 % CI 3.26-22.83, p = 0.001; P heterogeneity = 0.030). However, no significant association was found between breast density and breast cancer risk in premenopausal women except for those with large-sized tumors (>2 cm) and a Ki67 index >15 %.
  
  
  CONCLUSIONS
  High volumetric breast density is significantly associated with the risk of breast cancer in postmenopausal women; however, these relationships were not found in premenopausal women.
authors.affiliation: Center For Breast Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, Korea.
authors.forename: In Hae
authors.initials: IH
authors.lastname: Park
authors.forename: Kyungran
authors.initials: K
authors.lastname: Ko
authors.forename: Jungnam
authors.initials: J
authors.lastname: Joo
authors.forename: Boram
authors.initials: B
authors.lastname: Park
authors.forename: So-Youn
authors.initials: SY
authors.lastname: Jung
authors.forename: Seeyoun
authors.initials: S
authors.lastname: Lee
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Kwon
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Kang
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Lee
authors.forename: Keun Seok
authors.initials: KS
authors.lastname: Lee
authors.forename: Jungsil
authors.initials: J
authors.lastname: Ro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data; D015992:Body Mass Index; D000071060:Breast Density; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000473:pathology; D016022:Case-Control Studies; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000002:abnormalities*; D008327:Mammography; D008875:Middle Aged; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D056910:Republic of Korea / Q000453:epidemiology; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires