title: Jumonji family histone demethylases in neural development.
abstract: Central nervous system (CNS) development is driven by coordinated actions of developmental signals and chromatin regulators that precisely regulate gene expression patterns. Histone methylation is a regulatory mechanism that controls transcriptional programs. In the last 10 years, several histone demethylases (HDM) have been identified as important players in neural development, and their implication in cell fate decisions is beginning to be recognized. Identification of the physiological roles of these enzymes and their molecular mechanisms of action will be necessary for completely understanding the process that ultimately generates different neural cells in the CNS. In this review, we provide an overview of the Jumonji family of HDMs involved in neurodevelopment, and we discuss their roles during neural fate establishment and neuronal differentiation.
authors.affiliation: Department of Molecular Genomics, Instituto de Biología Molecular de Barcelona (IBMB), Consejo Superior de Investigaciones Científicas (CSIC), Parc Científic de Barcelona (PCB), Barcelona, 08028, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Fueyo
authors.forename: María Alejandra
authors.initials: MA
authors.lastname: García
authors.forename: Marian A
authors.initials: MA
authors.lastname: Martínez-Balbás
mesh_terms: D000818:Animals; D056466:Histone Demethylases / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family; D009420:Nervous System / Q000254:growth & development* / Q000473:pathology; D009422:Nervous System Diseases / Q000201:enzymology / Q000473:pathology; D055495:Neurogenesis
chemical_list: D056466:Histone Demethylases