title: [Terpenoids and sterols from Ricinus communis and their activities against diabetes].
abstract: Seven terpenoids and three sterols were isolated from the methanol extracts of the aerial parts of Ricinus communis by chromatography methods and their structures were identified by spectra analysis as ficusic acid( 1), phytol(2), callyspinol(3) , lupeol(4), 30-norlupan-3beta-ol-20-one(5) , lup-20(29)-en-3beta,15alpha-diol(6) , acetylaleuritolic acid( 7), stigmast4-en-3-one(8) , stig-mast-4-en-6beta-ol-3-one(9) , and stigmast4-en-3,6-dione(10). Compounds 1-3 and 5-10 were obtained from this species for the first time and 5 and 6 showed significant inhibitive activity and good selectivity against 11beta-HSD of mouse and human in vitro. [Key words] Ricinus communis; terpenoids; sterols; 11beta-HSD
authors.forename: Shen-Hua
authors.initials: SH
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lai
authors.forename: Heng-Shan
authors.initials: HS
authors.lastname: Wang
authors.forename: Qin-Gang
authors.initials: QG
authors.lastname: Tan
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000037:antagonists & inhibitors; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D051379:Mice; D012278:Ricinus / Q000737:chemistry*; D013261:Sterols / Q000494:pharmacology* / Q000627:therapeutic use; D013729:Terpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007004:Hypoglycemic Agents; D013261:Sterols; D013729:Terpenes; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2