title: Inhibitory effect of sodium houttuyfonate on synovial proliferationin vitroin cells from a patient with rheumatoid arthritis.
abstract: The aim of the present study was to investigate the inhibitory effect of sodium houttuyfonate (SH) on synovial cell proliferationin vitro. Primary cells were obtained from the synovial tissue of a patient with rheumatoid arthritis (RA). The cells were divided into five treatment groups as follows: the control group (group 1), 25 μg/ml SH-treated group (group 2), 50 μg/ml SH-treated group (group 3), 100 μg/ml SH-treated group (group 4) and the 200 μg/ml SH-treated group (group 5). Following seven days of treatment, the proliferation rate of the synovial cells was then detected using an MTT assay. The expression level of proliferative synovial cells markedly decreased in the SH-treated groups in a dose-dependent manner compared with the control group. In conclusion, the present study demonstrated that SH was able to inhibit the proliferation of synovial cells obtained from a patient with RA. These results provide a potential theoretical basis for the development of a safe and effective treatment against RA in the future.
authors.affiliation: Department of Rheumatology and Immunology, Shanghai Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Immunology, Huainan First People's Hospital, Huainan, Anhui 232000, P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Rheumatology and Immunology, Shanghai Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, P.R. China.
authors.forename: Futao
authors.initials: F
authors.lastname: Zhao
keywords: MTT assay; rheumatoid arthritis; sodium houttuyfonate; synovial proliferation