title: Concurrent subcutaneous candidal abscesses and pulmonary cryptococcosis in a patient with diabetes mellitus and a history of corticosteroid therapy.
abstract: A 50-year-old man with a history of long-term corticosteroid treatment following adrenalectomy for Cushing's syndrome and uncontrolled diabetes mellitus was admitted for an examination of an abnormal thoracic shadow. Cryptococcal serum antigens were positive, and the histopathology of a lung biopsy showed encapsulated yeast resembling Cryptococcus neoformans. On admission, the serum β-D-glucan level was approximately twice the cutoff value, several nodules were observed on both legs and magnetic resonance imaging revealed subcutaneous abscesses. Candida albicans was identified from needle aspirates, and the patient was successfully treated with fluconazole and flucytosine. We herein report the first case of concurrent C. albicans skin abscesses and pulmonary cryptococcosis.
authors.affiliation: Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kakeya
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamada
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Narita
authors.forename: Tomoya
authors.initials: T
authors.lastname: Nishino
authors.forename: Yoko
authors.initials: Y
authors.lastname: Obata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takazono
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kurihara
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kosai
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Morinaga
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Imamura
authors.forename: Taiga
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Misuzu
authors.initials: M
authors.lastname: Tsukamoto
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Motoi
authors.initials: M
authors.lastname: Takenaka
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000209:etiology*; D000315:Adrenalectomy; D002176:Candida albicans; D002179:Candidiasis, Cutaneous / Q000175:diagnosis / Q000209:etiology*; D003453:Cryptococcosis / Q000175:diagnosis / Q000209:etiology*; D003480:Cushing Syndrome / Q000150:complications / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged
chemical_list: D005938:Glucocorticoids