title: Intraosseous angiolipoma of the frontal bone with a unique location: a clinical and pathological case illustration and review of the literature.
abstract: Here, we report a case of a 16-year-old female patient was referred with scalp swelling and headache. Her neurological examination was normal and imaging of the skull revealed a well-defined lytic lesion measuring 15 mm × 6 mm to the right of the frontal bone. She was operated on with a prediagnosis of Langerhans cell histiocytosis. A wide excision with negative margins was made and the defect was reconstructed with a titanium plate. Subsequently, the lesion was histopathologically diagnosed as an angiolipoma of the frontal bone. The postoperative period was uneventful and she remained well during 1-year follow-up with no evidence of recurrence. Angiolipomas are rare benign lipomatous lesions located mostly in subcutaneous tissue of the forearm or trunk and frequently occur before puberty or in young adults. They are not common in bones. To the best of our knowledge, this is the first angiolipoma of the frontal bone reported.
authors.affiliation: Department of Pathology, Baskent University, School of Medicine, Ankara, Turkey.
authors.forename: Alev Ok
authors.initials: AO
authors.lastname: Atilgan
authors.forename: Aysen
authors.initials: A
authors.lastname: Terzi
authors.forename: Muhtesem
authors.initials: M
authors.lastname: Agildere
authors.forename: Hakan
authors.initials: H
authors.lastname: Caner
authors.forename: B Handan
authors.initials: BH
authors.lastname: Ozdemir
mesh_terms: D000293:Adolescent; D018206:Angiolipoma / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D018952:Antigens, CD34 / Q000032:analysis; D005260:Female; D005624:Frontal Bone / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008853:Microscopy; D012886:Skull / Q000000981:diagnostic imaging; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A