title: Effects of obstetric complications on volume and functional connectivity of striatum in anorexia nervosa patients.
abstract: OBJECTIVE
  To investigate the volume and functional connectivity of dorsal and ventral striatal nuclei in anorexia nervosa (AN) and their relationship with early exposure to obstetric complications.
  
  
  METHODS
  Fifty-one patients with lifetime AN (35 acute, 16 recovered) and 34 healthy controls underwent high-resolution and resting-state functional magnetic resonance imaging.
  
  
  RESULTS
  The AN group showed reduced functional connectivity of the putamen compared with healthy women, and this reduction was more evident in patients with lifetime binge eating/purging. Both acute and recovered AN groups showed a larger left accumbens area compared with that of healthy women. The functional connectivity of bilateral nucleus accumbens and putamen showed significant negative correlations with number of obstetric complications in the AN group.
  
  
  CONCLUSIONS
  This study supports the hypothesis that AN is associated with structural and functional alterations of striatal networks, and reveals the possible role of obstetric complications in the pathogenesis of striatal dysfunction.
authors.affiliation: Department of Neurosciences, University of Padova, Padova, Italy; Centro di Neuroscienze Cognitive, Università di Padova.
authors.forename: Angela
authors.initials: A
authors.lastname: Favaro
authors.forename: Elena
authors.initials: E
authors.lastname: Tenconi
authors.forename: Daniela
authors.initials: D
authors.lastname: Degortes
authors.forename: Renzo
authors.initials: R
authors.lastname: Manara
authors.forename: Paolo
authors.initials: P
authors.lastname: Santonastaso
mesh_terms: D000328:Adult; D017668:Age of Onset; D000856:Anorexia Nervosa / Q000473:pathology / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009714:Nucleus Accumbens / Q000196:embryology / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology / Q000503:physiopathology*; D011699:Putamen / Q000196:embryology / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult
keywords: anorexia nervosa; fMRI; functional connectivity; obstetric complications; striatum