title: Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells.
abstract: A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ, 08854, USA.
authors.forename: Perry T
authors.initials: PT
authors.lastname: Yin
authors.forename: Birju P
authors.initials: BP
authors.lastname: Shah
authors.forename: Ki-Bum
authors.initials: KB
authors.lastname: Lee
mesh_terms: D017209:Apoptosis; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D006979:Hyperthermia, Induced; D008280:Magnetics; D035683:MicroRNAs / Q000008:administration & dosage*; D053758:Nanoparticles
chemical_list: D035683:MicroRNAs
keywords: drug delivery; hyperthermia; magnetic nanoparticles; microRNA; nanotechnology