title: Pharmacological and behavioral management of some often-overlooked clozapine-induced side effects.
abstract: This article reviews four of the milder but still bothersome side effects of clozapine that are fairly frequent and may have a negative impact on patients' compliance with the treatment regime. We reviewed the available literature on the rate and management of four non-life-threatening side effects of clozapine, including hypersalivation, constipation, tachycardia, and nocturnal enuresis. We found a variety of pharmacological and behavioral strategies to manage these four side effects. There is, however, no consensus on a preferred strategy to control these distressing side effects and there are no guidelines. Psychiatrists should be aware of the relatively high rate of hypersalivation, constipation, tachycardia, and nocturnal enuresis in clozapine-treated patients, of the impact that these side effects may have on patients' quality of life, and should be able to suggest management strategies to the patients.
authors.affiliation: aResearch Unit, Geha Mental Health Center bFelsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva cSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Roi
authors.initials: R
authors.lastname: Sagy
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Nachum
authors.initials: N
authors.lastname: Katz
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D003248:Constipation / Q000139:chemically induced / Q000178:diet therapy / Q000188:drug therapy*; D006801:Humans; D053206:Nocturnal Enuresis / Q000139:chemically induced / Q000188:drug therapy*; D012798:Sialorrhea / Q000139:chemically induced / Q000188:drug therapy* / Q000628:therapy; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine