title: ATP signaling in skeletal muscle: from fiber plasticity to regulation of metabolism.
abstract: Tetanic electrical stimulation releases adenosine triphosphate (ATP) from muscle fibers through pannexin-1 channels in a frequency-dependent manner; extracellular ATP activates signals that ultimately regulate gene expression and is able to increase glucose transport through activation of P2Y receptors, phosphatidylinositol 3-kinase, Akt, and AS160. We hypothesize that this mechanism is an important link between exercise and the regulation of muscle fiber plasticity and metabolism.
authors.affiliation: 1Center for Molecular Studies of the Cell, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile; and 2Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
authors.forename: Mariana
authors.initials: M
authors.lastname: Casas
authors.forename: Sonja
authors.initials: S
authors.lastname: Buvinic
authors.forename: Enrique
authors.initials: E
authors.lastname: Jaimovich
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D001692:Biological Transport; D020746:Calcium Channels, L-Type / Q000378:metabolism; D017630:Connexins / Q000378:metabolism; D004558:Electric Stimulation; D015444:Exercise / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020746:Calcium Channels, L-Type; D017630:Connexins; D020690:GTPase-Activating Proteins; D009419:Nerve Tissue Proteins; D009711:Nucleotides; C492764:PANX1 protein, human; D018048:Receptors, Purinergic P2; C518767:TBC1D4 protein, human; D015544:Inositol 1,4,5-Trisphosphate; D000255:Adenosine Triphosphate; D058539:Phosphatidylinositol 3-Kinase; D005947:Glucose