title: Breast cancer and pregnancy: a comparative analysis of a Chilean cohort.
abstract: BACKGROUND
  Recent reports show that pregnancy-associated breast cancer (PABC) survival is similar to that of non-pregnant young patients. We evaluate the characteristics and prognosis of PABC patients treated in our cancer centre.
  
  
  METHODS
  We identified patients with invasive PABC who were treated between 1999 and May 2013 and compared their characteristics with a no PABC cohort of similar age.
  
  
  RESULTS
  The prevalence of PABC was 1% (n = 17). The median age was 35 years (range: 29- 42 years). The initial tumour was suspected clinically in 93% of the cases. Total mastectomy rates were higher in women with PABC (78.6% versus 40.5%, p = 0.02), and more tumours in the PABC group were triple negative, epidermal growth factor type 2 (HER2)-positive, and at advanced stages; however, these differences were not statistically significant. While estimated overall survival at ten years was higher in the non-PABC group (75.5% versus 80.5%, p = 0.043), disease-specific survival (DSS) rate at ten years was not statistically different between groups (83.9% for PABC and 75.5% for unrelated pregnancy BC, p = 0.37).
  
  
  CONCLUSIONS
  PABC is a rare event. In our cohort, it tended to be more aggressive. Compared with a similar age cohort, the DSS was not worse.
authors.affiliation: Haematology-Oncology Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: César
authors.initials: C
authors.lastname: Sánchez
authors.affiliation: Haematology-Oncology Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Acevedo
authors.affiliation: Haematology-Oncology Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: Lidia
authors.initials: L
authors.lastname: Medina
authors.affiliation: Haematology-Oncology Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Ibáñez
authors.affiliation: Radiology Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: Dravna
authors.initials: D
authors.lastname: Razmilic
authors.affiliation: Radiology Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Elena Navarro
authors.affiliation: Oncology-Surgery Department, Cancer Programme, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Camus
keywords: breast cancer; pregnancy; prognosis