title: Does Teno Torque Virus Induce Autoimmunity After Hematopoietic Stem Cell Transplantation? A Case Report.
abstract: Teno Torque virus, member of the family of Anelloviridae, has been associated with many autoimmune diseases such as idiopathic hepatitis, systemic lupus erythematosus, and multiple sclerosis. Its viral load tends to be higher in the bone marrow and in tissues with high turnover rate. We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis. Extremely high-cytokine IP-10 and eotaxin levels were found in her sera, and serological tests and RT-PCR for viruses showed positive results exclusively for Teno Torque virus.
authors.affiliation: *Department of Pediatric Hemato Oncology ‡Pharmacy and Clinical Pharmacology, Institute for Maternal and Child Health IRCCS "Burlo Garofolo" †Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy.
authors.forename: Natalia
authors.initials: N
authors.lastname: Maximova
authors.forename: Antonio
authors.initials: A
authors.lastname: Pizzol
authors.forename: Giovanna
authors.initials: G
authors.lastname: Ferrara
authors.forename: Alessandra
authors.initials: A
authors.lastname: Maestro
authors.forename: Paolo
authors.initials: P
authors.lastname: Tamaro
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D015551:Autoimmunity / Q000276:immunology*; D004266:DNA Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006505:Hepatitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000628:therapy / Q000821:virology; D011379:Prognosis; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D019562:Viral Load
chemical_list: D004279:DNA, Viral