title: Identification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people.
abstract: BACKGROUND
  Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks.
  
  
  METHODS
  Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C.
  
  
  RESULTS
  The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes.
  
  
  CONCLUSIONS
  Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies.
authors.affiliation: Department of Clinical Chemistry, University and University Hospital of Liège, Liège, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Le Goff
authors.affiliation: Department of Motility Sciences, University and University Hospital of Liège, Liège, Belgium.|Multidisciplinary Department of Sports Medicine and Traumatology - SPORTS2, University Hospital of Liège, Liège, Belgium.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Kaux
authors.affiliation: Department of Motility Sciences, University and University Hospital of Liège, Liège, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Couffignal
authors.affiliation: Department of Motility Sciences, University and University Hospital of Liège, Liège, Belgium.
authors.forename: Romain
authors.initials: R
authors.lastname: Coubard
authors.affiliation: Multidisciplinary Department of Sports Medicine and Traumatology - SPORTS2, University Hospital of Liège, Liège, Belgium.|Cardiology Department, University Hospital of Liège, Liège, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Mélon
authors.affiliation: Department of Clinical Chemistry, University and University Hospital of Liège, Liège, Belgium.
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.affiliation: Department of Motility Sciences, University and University Hospital of Liège, Liège, Belgium.|Multidisciplinary Department of Sports Medicine and Traumatology - SPORTS2, University Hospital of Liège, Liège, Belgium.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Croisier
mesh_terms: D015444:Exercise / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D007155:Immunologic Factors / Q000097:blood*; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000097:blood*; D055815:Young Adult
chemical_list: D007155:Immunologic Factors; D017382:Reactive Oxygen Species
keywords: cardiac biomarkers; isokinetic; maximal concentric exercise; oxidative stress