title: Photoacoustic resonance spectroscopy for biological tissue characterization.
abstract: By "listening to photons," photoacoustics allows the probing of chromosomes in depth beyond the optical diffusion limit. Here we report the photoacoustic resonance effect induced by multiburst modulated laser illumination, which is theoretically modeled as a damped mass-string oscillator and a resistor-inductor-capacitor (RLC) circuit. Through sweeping the frequency of multiburst modulated laser, the photoacoustic resonance effect is observed experimentally on phantoms and porcine tissues. Experimental results demonstrate different spectra for each phantom and tissue sample to show significant potential for spectroscopic analysis, fusing optical absorption and mechanical vibration properties. Unique RLC circuit parameters are extracted to quantitatively characterize phantom and biological tissues.
authors.affiliation: Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Feng
authors.affiliation: Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore.
authors.forename: Yuanjin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Nanyang Technological University, School of Physical and Mathematical Sciences, 50 Nanyang Avenue, 639798 Singapore.
authors.forename: Claus-Dieter
authors.initials: CD
authors.lastname: Ohl
mesh_terms: D000162:Acoustics; D000818:Animals; D025802:Electric Capacitance; D017097:Electric Impedance; D004867:Equipment Design; D007091:Image Processing, Computer-Assisted; D055095:Optics and Photonics; D009991:Oscillometry; D010100:Oxygen / Q000737:chemistry; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques; D013057:Spectrum Analysis / Q000379:methods*; D013314:Stress, Mechanical; D013552:Swine; D014159:Transducers; D014465:Ultrasonics
chemical_list: D010100:Oxygen