title: Design of a breath analysis system for diabetes screening and blood glucose level prediction.
abstract: It has been reported that concentrations of several biomarkers in diabetics' breath show significant difference from those in healthy people's breath. Concentrations of some biomarkers are also correlated with the blood glucose levels (BGLs) of diabetics. Therefore, it is possible to screen for diabetes and predict BGLs by analyzing one's breath. In this paper, we describe the design of a novel breath analysis system for this purpose. The system uses carefully selected chemical sensors to detect biomarkers in breath. Common interferential factors, including humidity and the ratio of alveolar air in breath, are compensated or handled in the algorithm. Considering the intersubject variance of the components in breath, we build subject-specific prediction models to improve the accuracy of BGL prediction. A total of 295 breath samples from healthy subjects and 279 samples from diabetic subjects were collected to evaluate the performance of the system. The sensitivity and specificity of diabetes screening are 91.51% and 90.77%, respectively. The mean relative absolute error for BGL prediction is 21.7%. Experiments show that the system is effective and that the strategies adopted in the system can improve its accuracy. The system potentially provides a noninvasive and convenient method for diabetes screening and BGL monitoring as an adjunct to the standard criteria.
authors.forename: Ke
authors.initials: K
authors.lastname: Yan
authors.forename: David
authors.initials: D
authors.lastname: Zhang
authors.forename: Darong
authors.initials: D
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis*; D001944:Breath Tests / Q000295:instrumentation* / Q000379:methods; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D062609:Electronic Nose; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
chemical_list: D001786:Blood Glucose