title: Oral 4-week and 13-week toxicity studies of polyvinyl acetate vinyl laurate copolymer in rats.
abstract: Polyvinyl acetate vinyl laurate copolymer (PVAcVL) is a useful component of gum base for chewing gum production. The safety of PVAcVL was examined in a 4-week and a 13-week oral toxicity study in rats. Finely powdered PVAcVL was administered with the diet at levels of 1.25%, 2.0% and 5% in the 4-week study and 1.25%, 2.5% and 5% in the 13-week study. There were no treatment related effects on mortality, bodyweight gains feed efficiency, ophthalmoscopic findings, hematological and clinical chemical parameters, neurobehavioral observations as well as gross and histopathological changes of standard organs and tissues. The highest dose tested in the 13-week study (3783 and 4396mg/kgbw/d for males and females, respectively) proved to be a NOAEL.
authors.affiliation: Bioresco Ltd., Bundesstrasse 29, 4054 Basel, Switzerland.
authors.forename: Horst
authors.initials: H
authors.lastname: Messinger
authors.affiliation: Bioresco Ltd., Bundesstrasse 29, 4054 Basel, Switzerland. Electronic address: contact@bioresco.ch.
authors.forename: Albert
authors.initials: A
authors.lastname: Bär
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007848:Laurates / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D011108:Polymers / Q000737:chemistry / Q000633:toxicity*; D011145:Polyvinyls / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013997:Time Factors; D018675:Toxicity Tests
chemical_list: D007848:Laurates; D011108:Polymers; D011145:Polyvinyls; C013215:polyvinyl acetate
keywords: CAS 108-05-4; CAS 2146-71-6; CAS 26354-30-3; Polyvinyl acetate vinyl laurate copolymer; Repeated dose toxicity; Vinyl acetate; Vinyl laurate