title: Clinical Raman measurements under special ambient lighting illumination.
abstract: One challenge in facing the application of biomedical Raman spectroscopy is that the Raman signal is acquired in a dark operation room. It is inconvenient for both the operator and the patient because it is difficult for the operator to accurately and precisely locate the target in the dark environment, and the patient feels uncomfortable in such a setting. In this note, we propose a method to implement biomedical Raman measurement with an illumination source, by multiple filtering of the illumination and the collection optics. Experimental results are demonstrated on skin Raman measurement under 785-nm excitation.
authors.affiliation: British Columbia Cancer Research Center, Imaging Unit-Integrative Oncology Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, CanadabUniversity of British Columbia and Vancouver Coastal Health Research Institute, Photomedicine Institute, Department.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
authors.affiliation: British Columbia Cancer Research Center, Imaging Unit-Integrative Oncology Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Short
authors.affiliation: Verisante Technology Inc., Vancouver, BC V6M 2A3, Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Braun
authors.affiliation: University of British Columbia and Vancouver Coastal Health Research Institute, Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver, BC V5Z 4E8, Canada.
authors.forename: Harvey
authors.initials: H
authors.lastname: Lui
authors.affiliation: University of British Columbia and Vancouver Coastal Health Research Institute, Photomedicine Institute, Department of Dermatology and Skin Science, Vancouver, BC V5Z 4E8, Canada.
authors.forename: David
authors.initials: D
authors.lastname: McLean
authors.affiliation: British Columbia Cancer Research Center, Imaging Unit-Integrative Oncology Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, CanadabUniversity of British Columbia and Vancouver Coastal Health Research Institute, Photomedicine Institute, Department.
authors.forename: Haishan
authors.initials: H
authors.lastname: Zeng
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008029:Lighting / Q000379:methods*; D017060:Patient Satisfaction; D012867:Skin / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*