title: Primary relapse site pattern in women with triple-negative breast cancer.
abstract: Despite the remarkable improvements in breast cancer (BC) characterization, accurate prediction of BC clinical behavior is often still difficult to achieve. Some studies have investigated the association between the molecular subtype, namely the basal-like BC and the pattern of relapse, however only few investigated the association between relapse pattern and immunohistochemical defined triple-negative breast cancers (TNBCs). The aim of this study was to evaluate the pattern of relapse in patients with TNBC, namely the primary distant relapse site. One-hundred twenty nine (129) invasive breast carcinomas with follow-up information were classified according to the molecular subtype using immunohistochemistry for ER, PgR and Her2. The association between TNBC and distant relapse primary site was analyzed by logistic regression. Using multivariate logistic regression analysis patients with TNBC displayed only 0.09 (95% CI: 0.00-0.74; p=0.02) the odds of the non-TNBC patients of developing bone primary relapse. Regarding visceral and lymph-node relapse, no differences between in this cohort were found. Though classically regarded as aggressive tumors, TNBCs rarely development primary relapse in bone when compared to non-TNBC, a clinical relevant fact when investigating a metastasis of an occult or non-sampled primary BC.
authors.affiliation: IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal; Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA, USA.
authors.forename: Francisco
authors.initials: F
authors.lastname: Beca
authors.affiliation: Faculty of Medicine, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Santos
authors.affiliation: Department of Pathology, Faculty of Medicine, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.
authors.forename: Daniella
authors.initials: D
authors.lastname: Vieira
authors.affiliation: Department of Obstetrics and Gynaecology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Luiz
authors.initials: L
authors.lastname: Zeferino
authors.affiliation: Department of Pathology, Faculty of Medicine of Botucatu, São Paulo State University (UNESP), Botucatu, SP, Brazil.
authors.forename: Rozany
authors.initials: R
authors.lastname: Dufloth
authors.affiliation: IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal; Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, University Health Network, Toronto, ON, Canada. Electronic address: fernando.schmitt@uhn.ca.
authors.forename: Fernando
authors.initials: F
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D064726:Triple Negative Breast Neoplasms / Q000473:pathology*
keywords: Breast cancer; Metastasis; Recurrence; Relapse; Triple-negative