title: Sonographic findings during and after Platelet Rich Plasma injections in tendons.
abstract: Platelet rich plasma has been used in the treatment of tendinopathies, but the sonographic modifications of tendons have received less attention. In this paper we report the results of an ultrasound evaluation, performed during and after plasma injection, in patients with tendinopathy. The sonographic abnormalities and neovascularization were registered in twenty tendons. Three plasma injections (once a week) were performed, and a rehabilitation program was recommended. Pain and patients' satisfaction were evaluated. During the injections plasma spread along the collagen fibers, and an intratendineous cleft produced by the injected volume was observed. At 12 months two tendons regained a normal echotexture, while neovessels were absent in seven. The remaining tendons showed less abnormalities and neovascularization in comparison with baseline. The clinical improvement was earlier and more consistent. The discrepancy between the ultrasound and clinical results may be explained by the peculiar modalities of tendon healing induced by plasma administration.
authors.affiliation: Department of Medicine and Science of Aging, University G. D'Annunzio, Chieti-Pescara, Chieti Scalo, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Abate
authors.affiliation: Immunohaematology and Transfusional Medicine Service, "SS. Annunziata" Hospital, Chieti Scalo, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Verna
authors.affiliation: Immunohaematology and Transfusional Medicine Service, "SS. Annunziata" Hospital, Chieti Scalo, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Di Gregorio
authors.affiliation: Department of Medicine and Science of Aging, University G. D'Annunzio, Chieti-Pescara, Chieti Scalo, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Salini
authors.affiliation: Department of Medicine and Science of Aging, University G. D'Annunzio, Chieti-Pescara, Chieti Scalo, Italy.
authors.forename: Cosima
authors.initials: C
authors.lastname: Schiavone
keywords: neovascularization; platelet rich plasma; tendinopathy; ultrasound