title: Simultaneous solvent and J-modulation suppression in PGSTE-based diffusion experiments.
abstract: The most favourable solvent suppression methods that have been applied to PGSTE experiments for the measurement of diffusion are WATERGATE and excitation sculpting. However, both methods come with significant J-modulation line-shape distortions on multiplets, a phenomenon that is known to be of particular concern for DOSY data processing. Here, two new PGSTE experiments are proposed that suppress both the solvent peak and J-modulation based on the perfect echo WATERGATE sequence. This allows narrow suppression bandwidths and thus measurement of diffusion on peaks close to the solvent peak. Both sequences perform admirably and the better option depends on the priority one puts on the quality of the solvent suppression or signal loss due to T2 weighting. Gradient-based solvent suppression in PGSTE experiments can often be compromised by the variable, diffusion-encoding gradient pulses. Special emphasis is put on how to maximise the robustness of the solvent suppression.
authors.affiliation: NMR and Structure Analysis Unit, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B-9000 Gent, Belgium. Electronic address: Davy.Sinnaeve@UGent.be.
authors.forename: Davy
authors.initials: D
authors.lastname: Sinnaeve
keywords: DOSY; Diffusion; J-modulation; PGSTE; Perfect echo; Solvent suppression; WATERGATE