title: Alterations of the daily rhythms of HPT axis induced by chronic unpredicted mild stress in rats.
abstract: The relationship between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. However, the daily rhythm alteration of the functions of the hypothalamus pituitary thyroid axis (HPT) is uncertain. In the present study, we investigated the effects of chronic unpredictable mild stress (CUMS) on the daily rhythm alterations of triiodothyronine (T3), thyroxine (T4), and Thyroid Stimulating Hormone (TSH) in the plasma. We found that CUMS led to depressive-like behavior and the daily rhythm of T3, T4, and TSH in the plasma being disturbed, as well the plasma levels of T3 and T4 decreased compared to control group. Our findings indicate that CUMS not only induce hypofunction of HPT axis but also the disturbance of daily rhythm of PHT axis in rats.
authors.affiliation: Department of Psychology, Normal College, Shenzhen University, Shenzhen, 518060, China.
authors.forename: Tian-You
authors.initials: TY
authors.lastname: Guo
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Liu
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Xu
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Zhang
authors.forename: Su-Xia
authors.initials: SX
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Li-Guo
authors.initials: LG
authors.lastname: He
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Han-Dan
authors.initials: HD
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004195:Disease Models, Animal; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism*; D013959:Thyroid Diseases / Q000209:etiology / Q000378:metabolism*