title: Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in-vivo dual-modality PET/MR imaging.
abstract: Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of (69) Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful utilization of a (69) Ge-based agent for PET/MR imaging.
authors.affiliation: Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA; Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
authors.forename: Rubel
authors.initials: R
authors.lastname: Chakravarty
authors.forename: Hector F
authors.initials: HF
authors.lastname: Valdovinos
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Christina M
authors.initials: CM
authors.lastname: Lewis
authors.forename: Paul A
authors.initials: PA
authors.lastname: Ellison
authors.forename: Haiming
authors.initials: H
authors.lastname: Luo
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Meyerand
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Nickles
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis / Q000493:pharmacokinetics; D005240:Feasibility Studies; D005857:Germanium / Q000737:chemistry / Q000493:pharmacokinetics; D007553:Isotope Labeling / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics; D013194:Staining and Labeling / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D011868:Radioisotopes; D005857:Germanium
keywords: chelator-free radiolabeling; germanium-69; iron oxide nanoparticles; multimodality imaging; positron emission tomography/magnetic resonance (PET/MR) imaging