title: Hepatotoxicity, leucopenia and neutropenia associated with olanzapine therapy.
abstract: Hepatotoxicity, leukopenia and neutropenia are rarely associated with atypical antipsychotic drug therapy. The authors describe a case of a schizophrenic patient, who was treated twice with olanzapine, and who developed an increase of hepatic enzymes, jaundice, reduced WBC, neutropenia, and a high temperature. The patient was diagnosed as suffering from hepatocellular hepatitis, neutropenia and leucopenia. Neuroleptic treatment was discontinued immediately and the patient exhibited consequential clinical improvement. A review of the literature is included.
authors.affiliation: Abarbanel Mental Health Center, Bat-Yam and Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tchernichovsky
authors.forename: Pinkhas
authors.initials: P
authors.lastname: Sirota
keywords: drug-induced hepatitis; leucopenia; neutropenia; olanzapine