title: RNAi therapies: drugging the undruggable.
abstract: RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.
authors.affiliation: Departments of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
authors.forename: Sherry Y
authors.initials: SY
authors.lastname: Wu
authors.affiliation: Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Lopez-Berestein
authors.affiliation: Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.affiliation: Departments of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. asood@mdanderson.org.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
mesh_terms: D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D034622:RNA Interference / Q000502:physiology; D034741:RNA, Small Interfering / Q000235:genetics / Q000502:physiology
chemical_list: D034741:RNA, Small Interfering