title: Anti-tuberculosis drugs adverse reactions: a review of the Iranian literature.
abstract: BACKGROUND
  Tuberculosis (TB) treatment, in particular therapy for multidrug-resistant TB (MDR-TB), is associated with toxicities and adverse drug reactions (ADRs).
  
  
  METHODS
  This paper reviews Iranian literature reporting ADRs which occurred during tuberculosis treatment. English language papers were sourced from PubMed, ScienceDirect, Wiley, Ovid and Proquest, with Google Scholar searched for Persian language articles. Reported ADRs, proportion of patients with ADRs, risk factors and determinants, as well as the characteristics of the studies were reviewed. 21 articles were included; about 60% of them were in English and three included patients with MDR-TB. The ratio of ADR per capita was 1.9 (in 6 studies) and 33.63% of patients developed an ADR (in 7 studies). Hepatitis (2.5 - 45.3%) was reported in nearly all of the studies. The mean time from initiation of medication to development of hepatitis ranged from 4.67 to 25.25 days (in 6 studies). Most cases of mortality were due to hepatotoxicity. Except for comorbidities and female gender, other risk factors such as HIV and length of hospitalization were only reported in one article.
  
  
  CONCLUSIONS
  The pattern of ADRs in Iranian articles was found to be similar to many other studies in the present review. We suggest that future studies resolve the confounding factors in this area that are mentioned in this review.
authors.affiliation: Research Center for Rational Use of Drugs, Tehran University of Medical Sciences , Tehran , Iran kheirollah_gholami_2000@yahoo.com.
authors.forename: Mona
authors.initials: M
authors.lastname: Kargar
authors.forename: Ava
authors.initials: A
authors.lastname: Mansouri
authors.forename: Molouk
authors.initials: M
authors.lastname: Hadjibabaie
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Javadi
authors.forename: Mania
authors.initials: M
authors.lastname: Radfar
authors.forename: Kheirollah
authors.initials: K
authors.lastname: Gholami
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology*; D006801:Humans; D007492:Iran; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
keywords: Iran; adverse drug reaction; drug induced hepatotoxicity; multidrug-resistant tuberculosis; side effect; tuberculosis