title: Neural circuit assembly: economically wired by a single cadherin.
abstract: Neurons are thought to acquire shapes and configurations consistent with the wiring optimization principle. A new study sheds light on the underlying molecular mechanisms by demonstrating that N-cadherin-mediated differential adhesion determines relative neurite positioning in developing columnar synaptic modules.
authors.affiliation: MRC National Institute for Medical Research, Division of Molecular Neurobiology, London, NW7 1AA, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Kaschula
authors.affiliation: MRC National Institute for Medical Research, Division of Molecular Neurobiology, London, NW7 1AA, UK. Electronic address: isaleck@nimr.mrc.ac.uk.
authors.forename: Iris
authors.initials: I
authors.lastname: Salecker
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000502:physiology*; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology*
chemical_list: D015820:Cadherins; D029721:Drosophila Proteins