title: [Serotonin hypothesis and pulmonary artery hypertension].
abstract: Pulmonary arterial hypertension (PAH) is a progressive, complex disease leading to the right ventricular failure and premature death. PAH is characterized by increased pulmonary arterial pressure, increased vascular resistance, pulmonary vascular remodeling and endothelial dysfunction. Pathomechanism of this disease is still unknown. It has been suggested, that endothelial dysfunction is caused by unbalance between vasodilators and vasoconstrictors e.g. serotonin (5-HT). Previously, serotonin hypothesis was linked to the anorexigens, derivatives of fenfluramine, which are serotonin transporter (SERT) substrates. Nowadays, it has been proved that all elements of serotonergic system within pulmonary circulation participate in the developement of PAH. The tryptophan hydroxylase 1 (Tph-1) catalyses synthesis of 5-HT from tryptophan in the pulmonary arterial endothelial cells. 5-HT mediates contraction of pulmonary vessels via 5-HT1B and 5-HT2A receptors. 5-HT is also transported into pulmonary arterial smooth muscle cells via SERT and through activation of reactive oxygen species and Rho-kinase may contribute to contraction or/and, via stimulation of transcription factors, lead to proliferation and remodelling. There is also increasing number of evidence about functional interaction between 5-HT1B receptor and SERT in modulation of vasoconstriction and proliferation in pulmonary arteries. This review discusses the role of 5-HT in the development of PAH and highlights possible therapeutic targets within serotonergic system.
authors.affiliation: Zakład Fizjologii i Patofizjologii Doświadczalnej Uniwersytetu Medycznego w Białymstoku.
authors.forename: Monika
authors.initials: M
authors.lastname: Kloza
authors.affiliation: Zakład Fizjologii i Patofizjologii Doświadczalnej Uniwersytetu Medycznego w Białymstoku; Zakład Farmacji Klinicznej Uniwersytetu Medycznego w Białymstoku.
authors.forename: Marta
authors.initials: M
authors.lastname: Baranowska-Kuczko
authors.affiliation: Zakład Fizjologii i Patofizjologii Doświadczalnej Uniwersytetu Medycznego w Białymstoku.
authors.forename: Anna
authors.initials: A
authors.lastname: Pędzińska-Betiuk
authors.affiliation: Zakład Fizjologii i Patofizjologii Doświadczalnej Uniwersytetu Medycznego w Białymstoku.
authors.forename: Konrad
authors.initials: K
authors.lastname: Jackowski
authors.affiliation: Zakład Fizjologii i Patofizjologii Doświadczalnej Uniwersytetu Medycznego w Białymstoku.
authors.forename: Hanna
authors.initials: H
authors.lastname: Kozłowska
mesh_terms: D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism*; D009130:Muscle, Smooth / Q000378:metabolism; D032389:Myocytes, Smooth Muscle; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014365:Tryptophan Hydroxylase / Q000378:metabolism*; D066253:Vascular Remodeling / Q000502:physiology*
chemical_list: D044302:Receptor, Serotonin, 5-HT1B; D050486:Serotonin Plasma Membrane Transport Proteins; D014157:Transcription Factors; D012701:Serotonin; D014365:Tryptophan Hydroxylase