title: Antifungal and antibacterial activity of Haliclona sp. from the Persian Gulf, Iran.
abstract: In this study, antifungal and antibacterial activities of diethyl ether, methanol and aqueous extracts of Haliclona sp. were assessed (in vitro). The antibacterial activity of the extracts was determined by broth dilution methods against clinical Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa and Gram-positive bacteria: Staphylococcus aureus aureus, Bacillus subtilis spizizenii. The antifungal activity of the extracts was determined by using a broth microdilution test against clinical fungi Candida albicans and Aspergillus fumigatus. Our results showed diethyl ether extract of Haliclona sp. was active on Gram-positive bacteria. In addition, methanol extract in comparison with diethyl ether extract had better activity against C. albicans (MIC: 0.75 mg/mL, MFC: 1.5mg/mL) and A. fumigatus (MIC: 2mg/mL, MFC: 3mg/mL). Aqueous extract had neither antifungal nor antibacterial activities. Based our results, Haliclona sp. can be considered as a source of novel antibiotic and antifungal.
authors.affiliation: Persian Gulf and Oman Sea Ecological Research Institute, Bandar Abbas, Iran. Electronic address: Melikanazemi@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Nazemi
authors.affiliation: Young Researchers and Elites club, North Tehran Branch, Islamic Azad University, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Alidoust Salimi
authors.affiliation: Young Researchers and Elites club, North Tehran Branch, Islamic Azad University, Tehran, Iran.
authors.forename: P
authors.initials: P
authors.lastname: Alidoust Salimi
authors.affiliation: Iranian Fisheries Research Organization, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Motallebi
authors.affiliation: Persian Gulf and Oman Sea Ecological Research Institute, Bandar Abbas, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Tamadoni Jahromi
authors.affiliation: Maritime of Hormozgan State, Hormozgan, Iran.
authors.forename: O
authors.initials: O
authors.lastname: Ahmadzadeh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000254:growth & development; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002457:Cell Extracts / Q000494:pharmacology; D047129:Haliclona / Q000737:chemistry; D006801:Humans; D019156:Indian Ocean; D007492:Iran; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002457:Cell Extracts
keywords: Activité biologique; Biological activity; Golfe Persique; Haliclona sp.; Marine sponge; Persian Gulf; Qeshm Island; Éponge marine; Île de Qeshm