title: Reward for food odors: an fMRI study of liking and wanting as a function of metabolic state and BMI.
abstract: Brain reward systems mediate liking and wanting for food reward. Here, we explore the differential involvement of the following structures for these two components: the ventral and dorsal striatopallidal area, orbitofrontal cortex (OFC), anterior insula and anterior cingulate. Twelve healthy female participants were asked to rate pleasantness (liking of food and non-food odors) and the desire to eat (wanting of odor-evoked food) during event-related functional magnetic resonance imaging (fMRI). The subjective ratings and fMRI were performed in hunger and satiety states. Activations of regions of interest were compared as a function of task (liking vs wanting), odor category (food vs non-food) and metabolic state (hunger vs satiety). We found that the nucleus accumbens and ventral pallidum were differentially involved in liking or wanting during the hunger state, which suggests a reciprocal inhibitory influence between these structures. Neural activation of OFC subregions was correlated with either liking or wanting ratings, suggesting an OFC role in reward processing magnitude. Finally, during the hunger state, participants with a high body mass index exhibited less activation in neural structures underlying food reward processing. Our results suggest that food liking and wanting are two separable psychological constructs and may be functionally segregated within the cortico-striatopallidal circuit.
authors.affiliation: Olfaction: From coding to memory team. INSERM, U1028, UMR 5292 CNRS, Lyon Neuroscience Research Center, University of Lyon, 69366 Lyon, France, Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS (UMR 6265), Université de Bourgogne-Inra, Dijon, France and CERMEP, Neurological Hospital, 69003 Lyon, France Olfaction: From coding to memory team. INSERM, U1028, UMR 5292 CNRS, Lyon Neuroscience Research Center, University of Lyon, 69366 Lyon, France, Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS (UMR 6265), Université de Bourgogne-Inra, Dijon, France and CERMEP, Neurological Hospital, 69003 Lyon, France.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Olfaction: From coding to memory team. INSERM, U1028, UMR 5292 CNRS, Lyon Neuroscience Research Center, University of Lyon, 69366 Lyon, France, Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS (UMR 6265), Université de Bourgogne-Inra, Dijon, France and CERMEP, Neurological Hospital, 69003 Lyon, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Soussignan
authors.affiliation: Olfaction: From coding to memory team. INSERM, U1028, UMR 5292 CNRS, Lyon Neuroscience Research Center, University of Lyon, 69366 Lyon, France, Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS (UMR 6265), Université de Bourgogne-Inra, Dijon, France and CERMEP, Neurological Hospital, 69003 Lyon, France.
authors.forename: Benoist
authors.initials: B
authors.lastname: Schaal
authors.affiliation: Olfaction: From coding to memory team. INSERM, U1028, UMR 5292 CNRS, Lyon Neuroscience Research Center, University of Lyon, 69366 Lyon, France, Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS (UMR 6265), Université de Bourgogne-Inra, Dijon, France and CERMEP, Neurological Hospital, 69003 Lyon, France Olfaction: From coding to memory team. INSERM, U1028, UMR 5292 CNRS, Lyon Neuroscience Research Center, University of Lyon, 69366 Lyon, France, Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS (UMR 6265), Université de Bourgogne-Inra, Dijon, France and CERMEP, Neurological Hospital, 69003 Lyon, France royet@olfac.univ-lyon1.fr.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Royet
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001931:Brain Mapping; D005260:Female; D005502:Food; D005518:Food Preferences; D005917:Globus Pallidus / Q000502:physiology; D006801:Humans; D006815:Hunger; D008279:Magnetic Resonance Imaging; D008297:Male; D008660:Metabolism / Q000502:physiology*; D009714:Nucleus Accumbens / Q000502:physiology; D009812:Odorants; D017397:Prefrontal Cortex / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012201:Reward; D012528:Satiety Response; D055815:Young Adult
keywords: body mass index; brain reward systems; food odors; liking and wanting; metabolic state