title: Rhodococcus equi (Prescottella equi) vaccines; the future of vaccine development.
abstract: For decades researchers have been targeting prevention of Rhodococcus equi (Rhodococcus hoagui/Prescottella equi) by vaccination and the horse breeding industry has supported the ongoing efforts by researchers to develop a safe and cost effective vaccine to prevent disease in foals. Traditional vaccines including live, killed and attenuated (physical and chemical) vaccines have proved to be ineffective and more modern molecular-based vaccines including the DNA plasmid, genetically attenuated and subunit vaccines have provided inadequate protection of foals. Newer, bacterial vector vaccines have recently shown promise for R. equi in the mouse model. This article describes the findings of key research in R. equi vaccine development and looks at alternative methods that may potentially be utilised.
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Giles
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Vanniasinkam
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Ndi
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
authors.forename: M D
authors.initials: MD
authors.lastname: Barton
mesh_terms: D000193:Actinomycetales Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D006734:Horse Diseases / Q000382:microbiology / Q000517:prevention & control*; D006736:Horses; D016929:Rhodococcus equi
chemical_list: D001428:Bacterial Vaccines
keywords: Prescottella equi; Rhodococcus equi; Rhodococcus hoagui; foal; horse; respiratory disease; vaccine