title: Pulsed electromagnetic field improves cardiac function in response to myocardial infarction.
abstract: Extracorporeal pulsed electromagnetic field (PEMF) has been shown the ability to improve regeneration in various ischemic episodes. Here, we examined whether PEMF therapy facilitate cardiac recovery in rat myocardial infarction (MI), and the cellular/molecular mechanisms underlying PEMF-related therapy was further investigated. The MI rats were exposed to active PEMF for 4 cycles per day (8 minutes/cycle, 30 ± 3 Hz, 5 mT) after MI induction. The data demonstrated that PEMF treatment significantly inhibited cardiac apoptosis and improved cardiac systolic function. Moreover, PEMF treatment increased capillary density, the levels of vascular endothelial growth factor (VEGF) and hypoxic inducible factor-1α in infarct border zone. Furthermore, the number and function of circulating endothelial progenitor cells were advanced in PEMF treating rats. In vitro, PEMF induced the degree of human umbilical venous endothelial cells tubulization and increased soluble pro-angiogenic factor secretion (VEGF and nitric oxide). In conclusion, PEMF therapy preserves cardiac systolic function, inhibits apoptosis and trigger postnatal neovascularization in ischemic myocardium.
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China ; Department of Cardiology, Nagoya University Graduate School of Medicine 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Chang-Ning
authors.initials: CN
authors.lastname: Hao
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China ; Department of Cardiology, Hua Dong Hospital, Fudan University West Yan'an Road 221, Shanghai 200040, China.
authors.forename: Jing-Juan
authors.initials: JJ
authors.lastname: Huang
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China ; Department of Cardiology, Nagoya University Graduate School of Medicine 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Yi-Qin
authors.initials: YQ
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Xian-Wu
authors.initials: XW
authors.lastname: Cheng
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China.
authors.forename: Hao-Yun
authors.initials: HY
authors.lastname: Li
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Hua Dong Hospital, Fudan University West Yan'an Road 221, Shanghai 200040, China.
authors.forename: Xin-Gui
authors.initials: XG
authors.lastname: Guo
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China ; Department of Cardiology, Hua Dong Hospital, Fudan University West Yan'an Road 221, Shanghai 200040, China.
authors.forename: Rui-Lin
authors.initials: RL
authors.lastname: Li
authors.affiliation: National Lab for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences Yu-Tian Road 500, Shanghai 200083, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University Zhang-Heng Road 826, Shanghai 201203, China.
authors.forename: Yi-Zhun
authors.initials: YZ
authors.lastname: Zhu
authors.affiliation: Department of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University Kongjiang Road 1665, Shanghai 200092, China ; Department of Cardiology, Hua Dong Hospital, Fudan University West Yan'an Road 221, Shanghai 200040, China.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Duan
keywords: Pulsed electromagnetic field; angiogenesis; apoptosis; cardiac function; ischemic myocardium