title: Selection response to DNA testing for canine ceroid lipofuscinosis in Tibetan terriers.
abstract: A late onset form of canine ceroid lipofuscinosis (CCL) is prevalent in Tibetan terriers. The disease is inherited as a monogenic recessive trait caused by aberrant exon skipping in ATP13A2. The aim of the present study was to analyse the frequencies of this mutation in Tibetan terriers registered with the German club for Tibetan dog breeds (Internationaler Klub für Tibetische Hunderassen, KTR) from 1987 to 2012 and to determine responses to selection following the introduction of DNA testing in 2010. The study included DNA extracted from blood samples from 1120/1240 (90.3%) Tibetan terriers registered with the KTR, including 405/420 (96.4%) registered breeding dogs. Mutant allele frequencies before the introduction of DNA testing were 0.20-0.28 in the registered and breeding dog populations, respectively, decreasing to 0.09 and 0.14, respectively, following the introduction of DNA testing.
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kluth
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Eckardt
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany. Electronic address: ottmar.distl@tiho-hannover.de.
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D004247:DNA / Q000097:blood*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005858:Germany; D009154:Mutation; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics*; D012641:Selection, Genetic; D013045:Species Specificity
chemical_list: D004247:DNA
keywords: ATP13A2; Canine ceroid lipofuscinosis; Selection; Tibetan terrier