title: Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population.
abstract: Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. Five hundred ESCC cases and 500 cancer-free controls of the Chinese Han population were involved in this study. The IGFBP-3 single-nucleotide polymorphism (SNP) rs2270628 was genotyped and the estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for its association with the risk of ESCC were determined using unconditional logistic regression analysis. Compared with the rs2270628 CC genotype, TT genotype was associated with a significantly increased ESCC risk with OR (95%CI) of 2.07 (1.05-4.09), but CT genotype was not (OR = 1.25, 95%CI =0.94-1.66). IGFBP-3 SNP rs2270628 may contribute to the risk of ESCC in the Chinese Han population.
authors.affiliation: Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China.
authors.forename: H-P
authors.initials: HP
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China junfengliucn@163.com.
authors.forename: J-F
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Institute of Molecular Genetics, Hebei United University, Tangshang, Hebei Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Rao
authors.affiliation: Institute of Molecular Genetics, Hebei United University, Tangshang, Hebei Province, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: H-L
authors.initials: HL
authors.lastname: Qian
authors.affiliation: Department of Thoracic Surgery, Cixian People's Hospital, Handan, Hebei Province, China.
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Niu
authors.affiliation: Department of Cardiothoracic, Zhongshan Hospital, Dalian University, Dalian, Liaoning Province, China.
authors.forename: Z-L
authors.initials: ZL
authors.lastname: Zhao
mesh_terms: D000368:Aged; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3