title: [Storing succinylcholine in prehospital settings following the recommendations of the French National Agency for the safety of medicines].
abstract: OBJECTIVE
  The French National Pharmaceuticals Agency (ANSM) has recommanded in July 2012 not to break the cold chain before using succinylcholine (Celocurine®).
  
  
  OBJECTIVE
  to understand the pre-clinical evolution of the conservation modes of this curare.
  Descriptive study before (year 2011) and after (year 2012).
  
  
  METHODS
  Online survey to French Samu/Smur.
  
  
  METHODS
  SMUR location, conservation method at clinical base, in the mobile unit (UMH) and at the patient. Principal decision criteria: evolution of the conservation modes before and after the recommendation (qualitatives variables compared with a Fisher test).
  
  
  RESULTS
  Out of 101 SAMU/SMUR, 62 answered. Conservation modes of succinylcholine vials were significantly different (P<0.001). Proper conservation was observed in 26 % of the cases before and 43 % after. Mobile units (UMH) equipped with a fridge increased from one out of two to 77 %. The lack of conservation modes passive or active on UMH went from 31 % to 3.4 % with isotherms bags with ice when a fridge was not available. The destruction of capsules at current temperature in a 24-hour period increased: 22 % before, 47 % after (P=0.04).
  
  
  CONCLUSIONS
  After recommendations from ANSM, conservation modes and destruction of succinylcholine in a prehospital environment were significantly impacted.
authors.affiliation: Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France. Electronic address: hdlefort@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Lefort
authors.affiliation: Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mendibil
authors.affiliation: Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Margerin
authors.affiliation: Pharmacie centrale, hôpital d'Instruction des Armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Cuquel
authors.affiliation: Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Jost
authors.affiliation: Samu Smur de Melun, rue Fréteau-de-Pény, 77011 Melun, France.
authors.forename: K
authors.initials: K
authors.lastname: Tazarourte
authors.affiliation: Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Domanski
authors.affiliation: Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Tourtier
mesh_terms: D003080:Cold Temperature; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D004632:Emergency Medical Services; D019538:Health Care Surveys; D006801:Humans; D009467:Neuromuscular Depolarizing Agents / Q000737:chemistry*; D012034:Refrigeration / Q000592:standards; D012449:Safety; D013390:Succinylcholine / Q000737:chemistry*
chemical_list: D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine
keywords: Celocurine; Conservation; Crash induction; Célocurine; Effets secondaires; Induction en séquence rapide; Out-of-hospital; Préhospitalier; Side effects; Storage temperatures; Succinylcholine; Suxamethonium; Suxaméthonium