title: [Treatment of antipsychotics induced mild hepatic damage by Dangfei Liganning Tablet: an efficacy observation].
abstract: OBJECTIVE
  To observe the therapeutic efficacy of Dangfei Liganning Tablet (DLT) in the treatment of antipsychotics induced mild hepatic damage.
  
  
  METHODS
  Totally 80 mental inpatients with antipsychotics induced mild liver injury were randomly assigned to two groups, the treatment group (40 cases) and the control group (40 cases). Patients in the treatment group took DLT, two tablets each time, three times per day, while those in the control group took Liver-protecting Tablet (LT), four tablets each time, three times per day. The treatment course was 4 weeks for all. Changes of glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminase (AST) were observed before treatment, week 1, 2, and 4 after treatment. The therapeutic efficacy was compared between the two groups.
  
  
  RESULTS
  Compared with the former time point, ALT and AST gradually decreased in the two groups at week 1, 2, and 4 (P <0. 05). The cured rate was 72. 5% and the total effective rate was 97. 5% in the treatment group. They were 62. 5% and 90. 0% respectively in the control group. There was no statistical difference in the two indices between the two group (P >0.05). No obvious adverse reaction occurred in the two groups.
  
  
  CONCLUSIONS
  DLT could treat antipsychotics induced mild hepatic damage in a safe and effective way.
authors.forename: Wei-Ti
authors.initials: WT
authors.lastname: Wu
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Chen
authors.forename: Xiao-Ye
authors.initials: XY
authors.lastname: Chen
mesh_terms: D006801:Humans; D000410:Alanine Transaminase / Q000378:metabolism; D014150:Antipsychotic Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D013607:Tablets / Q000627:therapeutic use
chemical_list: D000410:Alanine Transaminase; D014150:Antipsychotic Agents; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D013607:Tablets