title: Successful lung transplant in a child with cystic fibrosis and persistent Blastobotrys rhaffinosifermentans infection.
abstract: Fungal respiratory infections in patients with CF are a significant concern both pre- and post-lung transplantation (LTx). Fungal infection is associated with increased mortality post-LTx, and in the past decade, the prevalence of fungal colonization in Canadian pediatric patients with CF has increased. The emergence of novel fungal pathogens is particularly challenging to the transplant community, as little is known regarding their virulence and optimal management. We present a case of a successful double-lung transplant in a pediatric patient with CF who was infected pretransplantation with a novel yeast, Blastobotrys rhaffinosifermentans. This patient was treated successfully with aggressive antifungal therapy post-transplantation, followed by extended fungal prophylaxis. The significance of fungal colonization and infection in children with CF pre- and post-LTx is reviewed.
authors.affiliation: University of Alberta, Edmonton, AB, Canada.
authors.forename: J Y
authors.initials: JY
authors.lastname: Wong
authors.forename: A L
authors.initials: AL
authors.lastname: Chambers
authors.forename: J
authors.initials: J
authors.lastname: Fuller
authors.forename: A
authors.initials: A
authors.lastname: Lacson
authors.forename: J
authors.initials: J
authors.lastname: Mullen
authors.forename: D
authors.initials: D
authors.lastname: Lien
authors.forename: A
authors.initials: A
authors.lastname: Humar
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota; D001999:Bronchoscopy; D002170:Canada; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000628:therapy*; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation; D008168:Lung / Q000382:microbiology / Q000473:pathology; D016040:Lung Transplantation; D008297:Male; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000150:complications / Q000628:therapy*; D011183:Postoperative Complications; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents
keywords: fungal infection; fungal infections - cystic fibrosis; lung transplantation; pediatric lung transplantation; pediatric transplantation