title: Evaluation of physiological FDG uptake in the skeleton in adults: is it uniformly distributed?
abstract: OBJECTIVE
  The aim of this study was to study whether FDG was uniformly distributed throughout the skeleton and whether age and gender affected this biodistribution.
  
  
  METHODS
  A total of 158 patients were included in this retrospective study. None of the patients had received prior treatment that had affected the bone marrow and patients with bone metastases, trauma, benign and/or malignant hematologic disorders were excluded from the study. The SUVmax from the 24 different locations in the skeleton was obtained and all the values were compared with each other.
  
  
  RESULTS
  FDG uptake in the skeleton was not uniform in both sexes. While the highest FDG uptake was seen in the L3 vertebra, the lowest glucose metabolism was observed in the diaphysis of the femur. Concerning the vertebral column, FDG uptakes were also non-uniform and the SUVmax gradually increased from the cervix to the lumbar spine. The mean skeletal SUVmax was decreased in accordance with age in both genders.
  
  
  CONCLUSIONS
  FDG was not uniformly distributed throughout the skeleton in both sexes. It had a tendency to increase from the appendicular to axial skeleton and from cervical to lumbar spine in the vertebral column that may be related with the normal distribution of the red bone marrow. Additionally, the glycolytic metabolism of the whole skeleton was gradually decreased in accordance with the age in both sexes.
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey. Electronic address: drmustafa.aras@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aras
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Dede
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Tunc
authors.initials: T
authors.lastname: Ones
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Sabahat
authors.initials: S
authors.lastname: Inanır
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Tanju Yusuf
authors.initials: TY
authors.lastname: Erdıl
authors.affiliation: Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: Halil Turgut
authors.initials: HT
authors.lastname: Turoglu
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Bone marrow; Esqueleto; FDG; Glycolytic metabolism; Metabolismo glucolítico; Médula ósea; PET/CT; PET/TC; Skeleton