title: The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcet's disease.
abstract: OBJECTIVE
  Behçet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behçet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated.
  
  
  METHODS
  Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method.
  
  
  RESULTS
  There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD.
  
  
  CONCLUSIONS
  The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.
authors.affiliation: Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dursun
authors.affiliation: Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Cicek
authors.affiliation: Istanbul Training and Research Hospital, Medical Genetics Department, Istanbul, Turkey.
authors.forename: Fatih M
authors.initials: FM
authors.lastname: Keni
authors.affiliation: Bulent Ecevit University, Medical Faculty, Medical Genetics Dept., Zonguldak, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Karakas-Celik
authors.affiliation: Bulent Ecevit University, Medical Faculty, Dermatology Department, Zonguldak, Turkey.
authors.forename: Tuna
authors.initials: T
authors.lastname: Sezer
authors.affiliation: Selcuk University, Selcuklu Medical Faculty, Dermatology Department, Konya, Turkey.
authors.forename: Cevdet H
authors.initials: CH
authors.lastname: Altinyazar
mesh_terms: D000328:Adult; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001528:Behcet Syndrome / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology; D005123:Eye / Q000378:metabolism / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007596:Joints / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012720:Severity of Illness Index; D014421:Turkey
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human