title: Multidrug-resistant Staphylococcus hominis subsp. novobiosepticus causing septicemia in patients with malignancy.
abstract: A new subspecies of Staphylococcus hominis described by Kloos et al. in 1998 and named S. hominis subsp. novobiosepticus (SHN) has been implicated in nosocomial outbreaks. Multidrug resistance, including resistance to novobiocin and oxacillin, is a particularly important feature of SHN. In our institute, we encountered 13 cases of S. hominis subsp. hominis in cancer patients with septicemia, of which seven were methicillin resistant. The isolates were identified by VITEK ® 2 compact automated system, using GP REF 21342 identification card and antimicrobial susceptibility testing card P-628. The biochemical reactions and antibiotic susceptibility pattern of the seven methicillin-resistant isolates were re-analyzed and patient details were re-checked to finally identify them as SHN. The increasing number of cases reporting isolation of SHN from biological specimens point to potential virulence and clinical importance of this bacterium.
authors.forename: Priyamvada
authors.initials: P
authors.lastname: Roy
authors.affiliation: Department of Laboratory Medicine, Delhi State Cancer Institute, Dilshad Garden, New Delhi, India.
authors.forename: Nishat Hussain
authors.initials: NH
authors.lastname: Ahmed
authors.forename: Indu
authors.initials: I
authors.lastname: Biswal
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Grover
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D057205:Automation, Laboratory / Q000379:methods; D015373:Bacterial Typing Techniques; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D041181:Staphylococcus hominis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents