title: Interaction Between Hippocampus and Cerebellum Crus I in Sequence-Based but not Place-Based Navigation.
abstract: To examine the cerebellar contribution to human spatial navigation we used functional magnetic resonance imaging and virtual reality. Our findings show that the sensory-motor requirements of navigation induce activity in cerebellar lobules and cortical areas known to be involved in the motor loop and vestibular processing. By contrast, cognitive aspects of navigation mainly induce activity in a different cerebellar lobule (VIIA Crus I). Our results demonstrate a functional link between cerebellum and hippocampus in humans and identify specific functional circuits linking lobule VIIA Crus I of the cerebellum to medial parietal, medial prefrontal, and hippocampal cortices in nonmotor aspects of navigation. They further suggest that Crus I belongs to 2 nonmotor loops, involved in different strategies: place-based navigation is supported by coherent activity between left cerebellar lobule VIIA Crus I and medial parietal cortex along with right hippocampus activity, while sequence-based navigation is supported by coherent activity between right lobule VIIA Crus I, medial prefrontal cortex, and left hippocampus. These results highlight the prominent role of the human cerebellum in both motor and cognitive aspects of navigation, and specify the cortico-cerebellar circuits by which it acts depending on the requirements of the task.
authors.affiliation: Collège de France, LPPA, Paris 75005, France Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, Sorbonne Universités, UPMC Univ Paris 06, UMR-S 8246/ UM CR18, Paris F-75005, France Neuroscience Paris Seine, INSERM, UMR-S 1130, Cerebellum, Navigation and Memory Team, Paris F-75005, France Neuroscience Paris Seine, CNRS, UMR 8246, Cerebellum, Navigation and Memory Team, Paris F-75005, France Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience, University of Geneva, Geneva, Switzerland Current address: Fundamental Neuroscience Department, Geneva 1211, Switzerland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Iglói
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Doeller
authors.affiliation: Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, Sorbonne Universités, UPMC Univ Paris 06, UMR-S 8246/ UM CR18, Paris F-75005, France Neuroscience Paris Seine, INSERM, UMR-S 1130, Cerebellum, Navigation and Memory Team, Paris F-75005, France Neuroscience Paris Seine, CNRS, UMR 8246, Cerebellum, Navigation and Memory Team, Paris F-75005, France.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Paradis
authors.affiliation: Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, Sorbonne Universités, UPMC Univ Paris 06, UMR-S 8246/ UM CR18, Paris F-75005, France Neuroscience Paris Seine, INSERM, UMR-S 1130, Cerebellum, Navigation and Memory Team, Paris F-75005, France Neuroscience Paris Seine, CNRS, UMR 8246, Cerebellum, Navigation and Memory Team, Paris F-75005, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Benchenane
authors.affiliation: Collège de France, LPPA, Paris 75005, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Berthoz
authors.affiliation: UCL Institute of Cognitive Neuroscience and UCL Institute of Neurology, University College London, London WC1N 3AR, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Burgess
authors.affiliation: Collège de France, LPPA, Paris 75005, France Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, Sorbonne Universités, UPMC Univ Paris 06, UMR-S 8246/ UM CR18, Paris F-75005, France Neuroscience Paris Seine, INSERM, UMR-S 1130, Cerebellum, Navigation and Memory Team, Paris F-75005, France Neuroscience Paris Seine, CNRS, UMR 8246, Cerebellum, Navigation and Memory Team, Paris F-75005, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Rondi-Reig
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000098:blood supply / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D018782:Maze Learning / Q000502:physiology; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D065854:Spatial Navigation / Q000502:physiology*; D014584:User-Computer Interface; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: fMRI; functional connectivity; sequence learning; spatial memory; virtual reality