title: The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq.
abstract: In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6). All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC50 29.53 ± 0.19 μ g/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50 163.30 ± 0.32 μ g/mL). Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.
authors.affiliation: School of Pharmacy, Faculty of Science, Center for Natural and Medicinal Products Research, University of Nottingham (Malaysia Campus), Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: R
authors.initials: R
authors.lastname: Mogana
authors.affiliation: HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University Calcutta, West Bengal 700032, India.
authors.forename: S
authors.initials: S
authors.lastname: Debnath
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University Calcutta, West Bengal 700032, India.
authors.forename: S
authors.initials: S
authors.lastname: Hazra
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University Calcutta, West Bengal 700032, India.
authors.forename: B
authors.initials: B
authors.lastname: Hazra
authors.affiliation: School of Pharmacy, Faculty of Science, Center for Natural and Medicinal Products Research, University of Nottingham (Malaysia Campus), Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: K
authors.initials: K
authors.lastname: Teng-Jin
authors.affiliation: School of Pharmacy, Faculty of Science, Center for Natural and Medicinal Products Research, University of Nottingham (Malaysia Campus), Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
authors.forename: C
authors.initials: C
authors.lastname: Wiart
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D029403:Burseraceae / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry; D006801:Humans; D007891:Leishmania / Q000187:drug effects* / Q000201:enzymology; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D065947:Rainforest; D012603:Scopoletin / Q000008:administration & dosage
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase; D012603:Scopoletin