title: New cholinesterase inhibitors from Garcinia atroviridis.
abstract: A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
authors.forename: Wen-Nee
authors.initials: WN
authors.lastname: Tan
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. Electronic address: melati@usm.my.
authors.forename: Melati
authors.initials: M
authors.lastname: Khairuddean
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
authors.forename: Keng-Chong
authors.initials: KC
authors.lastname: Wong
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
authors.forename: Kooi-Yeong
authors.initials: KY
authors.lastname: Khaw
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
authors.forename: Murugaiyah
authors.initials: M
authors.lastname: Vikneswaran
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification*; D029760:Garcinia / Q000737:chemistry*; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D002800:Cholinesterase Inhibitors; D044950:Flavanones; D044948:Flavonols; C000596999:garcineflavanone A; C000597000:garcineflavonol A
keywords: Cholinesterase enzymes inhibitory activity; Clusiaceae; Garcinia atroviridis; Stem bark