title: [Pathomorphological peculiarities of hemomicrocirculatory bed of the small and large intestine in acute peritonitis].
abstract: Experimental comparative morphological investigation of hemomicrocirculation bed (HMCB) of the small and large bowel wall was performed in dynamics of an acute serous peritonitis. Spreaded aseptic peritonitis was simulated using injection of 5 ml of gamma-caraginen (Sigma, USA) in 1 ml of isotonic solution of sodium chloride. On the early stage of peritonitis (in 12 h from beginning of the experiment) in mucosa of small bowel nonsignificant venuls dilatation and the capillary lumen reduction were observed. In 1 day (reactive stage of peritonitis) in mucosa the quantity of capillars have had reduced significantly, comparing with such observed previously. On the 2-nd day (toxic stage of peritonitis) some capillary dilatation in intestinal villi and crypts coexistant with the blood rheology disorders in a form of stasis, change in permeability of the vessels walls, predominantly of the venous, was noted. On the 3-d day (late stage) the arteriol's spasm have had reduced, capillary paralytic dilatation was revealed. The staged course of experimental peritonitis with the HMCB changes, characteristic for every stage, was confirmed, basing on analysis of the investigation result.
authors.forename: V A
authors.initials: VA
authors.lastname: Siplivyĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Grinchenko
authors.forename: N I
authors.initials: NI
authors.lastname: Gorgol'
authors.forename: V V
authors.initials: VV
authors.lastname: Dotsenko
authors.forename: A V
authors.initials: AV
authors.lastname: Evtushenko
mesh_terms: D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000098:blood supply / Q000503:physiopathology; D007420:Intestine, Large / Q000098:blood supply* / Q000503:physiopathology; D007421:Intestine, Small / Q000098:blood supply* / Q000503:physiopathology; D008833:Microcirculation / Q000502:physiology*; D055806:Microvessels / Q000473:pathology / Q000503:physiopathology*; D010538:Peritonitis / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014664:Vasodilation / Q000502:physiology