title: Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.
abstract: Receptor tyrosine kinases are involved in regulation of key processes in endothelial biology, including proliferation, migration, and angiogenesis. It is now generally accepted that receptor tyrosine kinase signaling occurs intracellularly and on the plasma membrane, although many important details remain to be worked out. Endocytosis and subsequent intracellular trafficking spatiotemporally regulate receptor tyrosine kinase signaling, whereas signaling endosomes provide a platform for the compartmentalization of signaling events. This review summarizes recent advances in our understanding of endothelial receptor tyrosine kinase endocytosis and signaling using vascular endothelial growth factor receptor-2 as a paradigm.
authors.affiliation: From the Department of Cell Biology, and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: From the Department of Cell Biology, and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. michael.simons@yale.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Simons
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000502:physiology; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000503:physiopathology; D066246:ErbB Receptors / Q000502:physiology; D006801:Humans; D019899:Paracrine Communication; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000502:physiology; D019061:src-Family Kinases / Q000502:physiology
chemical_list: D066246:ErbB Receptors; D051057:Proto-Oncogene Proteins c-akt; D020794:Receptor Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1; D040301:Vascular Endothelial Growth Factor Receptor-2; D019061:src-Family Kinases; C064740:epidermal growth factor receptor-neu receptor
keywords: endocytosis; fibroblast growth factor receptor 1; myosin-VI; neuropilin; receptor, epidermal growth factor; synectin; vascular endothelial growth factor receptor-2