title: Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α.
abstract: OBJECTIVE
  We studied the effect of thalidomide on NFκB-induced TNF-α in acute pancreatitis-associated lung injury in the rat.
  
  
  METHODS
  Rats were intragastrically administered thalidomide (100mg/kg) daily for 8 days and then acute pancreatitis was induced by retrograde infusion of 5% sodium taurocholate into the rat biliopancreatic duct. Serum amylase (AMY), blood oxygen partial pressure (PaO2), ratios of lung wet/dry weight, and cytoplasmic IκBα and TNF-α protein and nuclear NFκBp65 protein were measured. Also, lung NFκBp65 and TNF-α mRNA were measured.
  
  
  RESULTS
  Compared with the model group, the pathological score of the pancreas and lung, serum AMY, ratios of lung wet/dry weight, and lung NFκBp65 and TNF-α mRNA and protein of rats given thalidomide were decreased significantly (P<0.01), but PaO2 and IκBα protein was elevated significantly (P<0.01).
  
  
  CONCLUSIONS
  Thalidomide may inhibit TNF-α expression via down-regulation of the NFκB signaling pathway to alleviate acute pancreatitis-associated lung injury in rats.
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, Jining, China. Electronic address: jnlvpeng@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, Jining, China.
authors.forename: Hong-Yun
authors.initials: HY
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, Jining, China.
authors.forename: Shu-Sheng
authors.initials: SS
authors.lastname: Ji
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, Jining, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, Jining, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Fan
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013792:Thalidomide / Q000494:pharmacology / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007166:Immunosuppressive Agents; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide
keywords: Acute pancreatitis; Lung injury; NFκB; TNF-α; Thalidomide