title: Reprogramming of mesenchymal stem cells by oncogenes.
abstract: Mesenchymal stem cells (MSCs) originate from embryonic mesoderm and give rise to the multiple lineages of connective tissues. Transformed MSCs develop into aggressive sarcomas, some of which are initiated by specific chromosomal translocations that generate fusion proteins with potent oncogenic properties. The sarcoma oncogenes typically prime MSCs through aberrant reprogramming. They dictate commitment to a specific lineage but prevent mature differentiation, thus locking the cells in a state of proliferative precursors. Deregulated expression of lineage-specific transcription factors and controllers of chromatin structure play a central role in MSC reprogramming and sarcoma pathogenesis. This suggests that reversing the epigenetic aberrancies created by the sarcoma oncogenes with differentiation-related reagents holds great promise as a beneficial addition to sarcoma therapies.
authors.affiliation: Department of Cancer Biology, Vanderbilt University Medical Center, 771 Preston, Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA. Electronic address: josiane.eid@vanderbilt.edu.
authors.forename: Josiane E
authors.initials: JE
authors.lastname: Eid
authors.affiliation: Department of Pediatrics-Nutrition, Baylor College of Medicine, BCM320, Huston, TX 77030, USA.
authors.forename: Christina B
authors.initials: CB
authors.lastname: Garcia
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D059630:Mesenchymal Stem Cells; D009857:Oncogenes / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors
keywords: Mesenchymal; Oncogene; Reprogramming; Sarcoma; Stem