title: Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta.
abstract: The widespread human exposure to Bisphenol A (BPA), an endocrine disruptor interfering with developmental processes, raises the question of the risk for human health of BPA fetal exposure. In humans, highly variable BPA concentrations have been reported in the feto-placental compartment. However the human fetal exposure to BPA still remains unclear. The aim of the study was to characterize placental exchanges of BPA and its main metabolite, Bisphenol A-Glucuronide (BPA-G) using the non-recirculating dual human placental perfusion. This high placental bidirectional permeability to the lipid soluble BPA strongly suggests a transport by passive diffusion in both materno-to-fetal and feto-to-maternal direction, leading to a calculated ratio between fetal and maternal free BPA concentrations of about 1. In contrast, BPA-G has limited placental permeability, particularly in the materno-to-fetal direction. Thus the fetal exposure to BPA conjugates could be explained mainly by its limited capacity to extrude BPA-G.
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: t.corbel@envt.fr.
authors.forename: T
authors.initials: T
authors.lastname: Corbel
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: v.gayrard@envt.fr.
authors.forename: V
authors.initials: V
authors.lastname: Gayrard
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: s.puel@envt.fr.
authors.forename: S
authors.initials: S
authors.lastname: Puel
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: m.lacroix@envt.fr.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Lacroix
authors.affiliation: Hôpital Paule de Viguier, Service de Gynécologie Obstétrique, CHU Toulouse, F-31059 Toulouse, France. Electronic address: berrebi.a@chu-toulouse.fr.
authors.forename: A
authors.initials: A
authors.lastname: Berrebi
authors.affiliation: INSERM, UMR-S 767 "Grossesse normale et pathologique", Faculté de Pharmacie, Université Paris Descartes, F-75006 Paris, France. Electronic address: sophie.gil@parisdescartes.fr.
authors.forename: S
authors.initials: S
authors.lastname: Gil
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: c.viguie@envt.fr.
authors.forename: C
authors.initials: C
authors.lastname: Viguié
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: pltoutain@wanadoo.fr.
authors.forename: P-L
authors.initials: PL
authors.lastname: Toutain
authors.affiliation: INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: n.hagen-picard@envt.fr.
authors.forename: N
authors.initials: N
authors.lastname: Picard-Hagen
mesh_terms: D001559:Benzhydryl Compounds / Q000378:metabolism*; D052244:Endocrine Disruptors / Q000378:metabolism*; D005260:Female; D020719:Glucuronides / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010636:Phenols / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D020719:Glucuronides; D010636:Phenols; C512161:bisphenol A glucuronide; D000098826:Bisphenol A Compounds; C006780:bisphenol A
keywords: Bisphenol A; Bisphenol A-Glucuronide; Endocrine disruptor; Fetal exposure; Human placenta