title: CGBayesNets: conditional Gaussian Bayesian network learning and inference with mixed discrete and continuous data.
abstract: Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous variables. Existing free BN software packages either discretize continuous variables, which can lead to information loss, or do not include inference routines, which makes prediction with the BN impossible. We present CGBayesNets, a BN package focused around prediction of a clinical phenotype from mixed discrete and continuous variables, which fills these gaps. CGBayesNets implements Bayesian likelihood and inference algorithms for the conditional Gaussian Bayesian network (CGBNs) formalism, one appropriate for predicting an outcome of interest from, e.g., multimodal genomic data. We provide four different network learning algorithms, each making a different tradeoff between computational cost and network likelihood. CGBayesNets provides a full suite of functions for model exploration and verification, including cross validation, bootstrapping, and AUC manipulation. We highlight several results obtained previously with CGBayesNets, including predictive models of wood properties from tree genomics, leukemia subtype classification from mixed genomic data, and robust prediction of intensive care unit mortality outcomes from metabolomic profiles. We also provide detailed example analysis on public metabolomic and gene expression datasets. CGBayesNets is implemented in MATLAB and available as MATLAB source code, under an Open Source license and anonymous download at http://www.cgbayesnets.com.
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McGeachie
authors.affiliation: Harvard Medical School, Boston, Massachusetts, United States of America; Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America.
authors.forename: Hsun-Hsien
authors.initials: HH
authors.lastname: Chang
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; Partners Health Care Center for Personalized Medicine, Boston, Massachusetts, United States of America.
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods*; D006801:Humans; D007362:Intensive Care Units; D020407:Internet; D007938:Leukemia / Q000235:genetics; D008954:Models, Biological; D016011:Normal Distribution; D010641:Phenotype; D012984:Software; D014934:Wood / Q000235:genetics