title: Two new butenolides produced by an Actinomycete Streptomyces sp.
abstract: Two new butenolides, (4S)-4,10-dihydroxydodec-2-en-1,4-olide (1) and (4S)-4,8,10-trihydroxy-10-methyldodec-2-en-1,4-olide (2), together with three known compounds, MKN-003B (3), MKN-003C (4), and cyclo(Ala-Leu) (5), were isolated from the culture broth of a bacterium of the genus Streptomyces derived from soil environment. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The inhibitory activities of the butenolides against eight pathogenic fungi were evaluated. All of the butenolides showed moderate-or-weak antifungal activities in a broth microdilution assay.
authors.affiliation: Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China (phone: +86-871-65032423).
authors.forename: Tang
authors.initials: T
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Kai-Xia
authors.initials: KX
authors.lastname: Ma
authors.forename: Yi-Qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Xie
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D039903:Actinobacteria / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; C004511:butenolide; D015107:4-Butyrolactone
keywords: Antifungal activity; Butenolides; Streptomyces