title: Intestinal IgA production and its role in host-microbe interaction.
abstract: Complex and diverse communities of bacteria establish mutualistic and symbiotic relationships with the gut after birth. The intestinal immune system responds to bacterial colonization by acquiring a state of hypo-responsiveness against commensals and active readiness against pathogens. The resulting homeostatic balance involves a continuous dialog between the microbiota and lymphocytes with the intermediation of epithelial and dendritic cells. This dialog causes massive production of immunoglobulin A (IgA), a non-inflammatory antibody specialized in mucosal protection. Here, we discuss recent advances on the regulation of intestinal IgA responses and their role in host-microbe interaction.
authors.affiliation: Immunology Institute, Department of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Gutzeit
authors.forename: Giuliana
authors.initials: G
authors.lastname: Magri
authors.forename: Andrea
authors.initials: A
authors.lastname: Cerutti
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007107:Immune System; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology*; D064307:Microbiota / Q000276:immunology*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D007070:Immunoglobulin A
keywords: B cells; T cells; class switching; dendritic cells; epithelial cells; immunoglobulin; mucosal immunity