title: ParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures.
abstract: ParaPep is a repository of antiparasitic peptides, which provides comprehensive information related to experimentally validated antiparasitic peptide sequences and their structures. The data were collected and compiled from published research papers, patents and from various databases. The current release of ParaPep holds 863 entries among which 519 are unique peptides. In addition to peptides having natural amino acids, ParaPep also consists of peptides having d-amino acids and chemically modified residues. In ParaPep, most of the peptides have been evaluated for growth inhibition of various species of Plasmodium, Leishmania and Trypanosoma. We have provided comprehensive information about these peptides that include peptide sequence, chemical modifications, stereochemistry, antiparasitic activity, origin, nature of peptide, assay types, type of parasite, mode of action and hemolytic activity. Structures of peptides consisting of natural, as well as modified amino acids have been determined using state-of-the-art software, PEPstr. To facilitate users, various user-friendly web tools, for data fetching, analysis and browsing, have been integrated. We hope that ParaPep will be advantageous in designing therapeutic peptides against parasitic diseases. Database URL: http://crdd.osdd.net/raghava/parapep/
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Mehta
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Anand
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Vineet
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Anshika
authors.initials: A
authors.lastname: Joshi
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Mathur
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Tuknait
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Kumardeep
authors.initials: K
authors.lastname: Chaudhary
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Shailendra K
authors.initials: SK
authors.lastname: Gautam
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India grish@imtech.res.in.
authors.forename: Grish C
authors.initials: GC
authors.lastname: Varshney
authors.affiliation: Cell biology and Immunology Division and Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India raghava@imtech.res.in.
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000494:pharmacology; D030562:Databases, Protein; D020407:Internet; D008969:Molecular Sequence Data; D010271:Parasites / Q000187:drug effects; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D015203:Reproducibility of Results; D014584:User-Computer Interface
chemical_list: D000977:Antiparasitic Agents; D010455:Peptides