title: Human stem cell models of dementia.
abstract: Positive predictions were made in the aftermath of the development of induced pluripotent stem cell technology for the use of patient-specific iPSCs to model neurological diseases, including dementia. Here, we review the current state of the field and explore how close we are to the goal of in vitro models that capture all aspects of the cell and molecular biology of dementia.
authors.affiliation: Gurdon Institute, Cambridge Stem Cell Institute & Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK rick@gurdon.cam.ac.uk.
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Livesey
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008957:Models, Genetic; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology; D016548:Prosencephalon / Q000166:cytology; D033581:Stem Cell Transplantation