title: A prospective randomized single-blind, multicenter trial comparing the efficacy and safety of paroxetine with and without quetiapine therapy in depression associated with anxiety.
abstract: OBJECTIVE To evaluate quetiapine as an adjunct to paroxetine in patients with comorbid depression and anxiety. METHOD Prospective, multicenter, single-blind trial of patients with DSM-IV major depression and associated anxiety, who were randomized to an 8-week treatment with paroxetine alone (n=54) or paroxetine+quetiapine (n=58). Quetiapine was dosed to 200 mg/day and paroxetine to 60 mg/day, as required. RESULTS Decrease in HAM-A scores was significantly greater in the combined therapy group than with paroxetine alone at weeks 2, 4, 6 and LOCF (P<0.008). Decrease in HAM-D scores was significantly greater in the combined therapy group than with paroxetine alone throughout the study period (P<0.008). Regarding adverse events, it was found that increases in anxiety and insomnia were more prevalent in the paroxetine only group, while increased appetite was more prevalent when quetiapine was added (P<0.05). CONCLUSION Quetiapine added to paroxetine is well tolerated and may speed up and improve response in patients with comorbid depression and anxiety.
authors.affiliation: Department of Psychiatry, Istanbul University Istanbul School of Medicine, Istanbul, Turkey.
authors.forename: L Ilhan
authors.initials: LI
authors.lastname: Yargic
authors.forename: Aytul
authors.initials: A
authors.lastname: Corapcioglu
authors.forename: Nese
authors.initials: N
authors.lastname: Kocabasoglu
authors.forename: Ayten
authors.initials: A
authors.lastname: Erdogan
authors.forename: Gulsah
authors.initials: G
authors.lastname: Koroglu
authors.forename: Dilek
authors.initials: D
authors.lastname: Yilmaz
keywords: anxiety; atypical antipsychotic; depression; paroxetine; quetiapine