title: Noncontinuous use of antidepressant in adults with major depressive disorders - a retrospective cohort study.
abstract: BACKGROUND
  Noncontinuous antidepressant use is frequently observed in clinical practice despite the standard recommendation of at least 6-9 months of continuous treatment. The problem may be more serious in Chinese populations where stigmatization is common. This retrospective cohort study investigated the rate of noncontinuous antidepressant use and subsequent rate of relapse and recurrence in psychiatric Chinese outpatients by examining the prescription records, electronic medical records, and written medical records. Factors associated with noncontinuous antidepressant use were also identified.
  
  
  METHODS
  We reviewed the medical records of 189 patients newly dispensed with an antidepressant in the psychiatric outpatient clinic during year 2006 and 2007. Primary outcome was the rate of noncontinuous antidepressant use within 6 months of therapy. Secondary outcomes included the factors associated with noncontinuous antidepressant use and the rate of subsequent depression relapse and recurrence within 1 year of starting treatment.
  
  
  RESULTS
  Among the 189 subjects included in this study, 46% were noncontinuous users of the newly prescribed antidepressant therapy. The noncontinuous users were found to have an eightfold increase (OR: 8.42, 95% CI: 3.30-21.47) in the risks of relapse/recurrence depressive episodes within 1 year after treatment initiation. Younger age (P = 0.008), female, (P = 0.029), residency in public housing estate (P = 0.029), experiencing side effects (P = 0.024), infrequent follow-ups (P = 0.006), and earlier onset of diagnosis (P = 0.034) were factors significantly associated with noncontinuous antidepressant use.
  
  
  CONCLUSIONS
  Noncontinuous antidepressant use is common in the local Chinese depressive patients and associated with a high rate of relapse and recurrence. Collaborative multidisciplinary approaches that target patient education and enhancement of follow-up adherence are needed.
authors.affiliation: Department of Pharmacy, Prince of Wales Hospital Shatin, Hong Kong.
authors.forename: Wai-Yin
authors.initials: WY
authors.lastname: Yau
authors.affiliation: Department of Pharmacy, Prince of Wales Hospital Shatin, Hong Kong.
authors.forename: Man-Chi
authors.initials: MC
authors.lastname: Chan
authors.affiliation: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong Shatin, Hong Kong.
authors.forename: Yun-Kwok
authors.initials: YK
authors.lastname: Wing
authors.affiliation: Department of Psychiatry, Prince of Wales Hospital Shatin, Hong Kong.
authors.forename: Ho-Bun
authors.initials: HB
authors.lastname: Lam
authors.affiliation: Department of Psychiatry, Prince of Wales Hospital Shatin, Hong Kong.
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.affiliation: Department of Psychiatry, Prince of Wales Hospital Shatin, Hong Kong.
authors.forename: Siu-Ping
authors.initials: SP
authors.lastname: Lam
authors.affiliation: Faculty of Medicine, School of Pharmacy, The Chinese University of Hong Kong Shatin, Hong Kong.
authors.forename: Chui-Ping
authors.initials: CP
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D000928:Antidepressive Agents
keywords: Adherence; antidepressant; depression; pharmacotherapy; treatment