title: Local treatment of the axilla in early breast cancer: concepts from the national surgical adjuvant breast and bowel project B-04 to the planned intergroup sentinel mamma trial.
abstract: Local treatment of the axilla in clinically node-negative, early-stage breast cancer patients has been hotly debated after the release of the American College of Surgeons Oncology Group (ACOSOG) Z0011 findings. However, this review does not focus on the 'Z0011-eligible' patients alone, because this subgroup represents a minority of our patients undergoing breast-conserving surgery (BCS) and sentinel lymph node biopsy (SLNB). The following topics are discussed: axillary diagnostics, timing of axillary procedures in the neoadjuvant setting, long-term follow-up of SLNB trials, omission of axillary surgery in randomized trials, management of the involved axilla with low tumor volume, positive sentinel lymph nodes and BCS, involved sentinel lymph nodes and mastectomy, and axillary radiotherapy. Finally, the current innovative study concepts (i.e. Sentinel Node versus Observation after Axillary Ultrasound (SOUND) and Intergroup Sentinel Mamma (INSEMA)) including patients with axillary observation alone in clinically node-negative women are presented.
authors.affiliation: Department of Obstetrics and Gynecology, University of Rostock, Germany.
authors.forename: Toralf
authors.initials: T
authors.lastname: Reimer
authors.affiliation: Department of Obstetrics and Gynecology, University of Rostock, Germany.
authors.forename: Steffi
authors.initials: S
authors.lastname: Hartmann
authors.affiliation: Department of Obstetrics and Gynecology, University of Rostock, Germany.
authors.forename: Angrit
authors.initials: A
authors.lastname: Stachs
authors.affiliation: Department of Obstetrics and Gynecology, University of Rostock, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Gerber
keywords: Axilla; Breast cancer; INSEMA; Radiotherapy; Surgery