title: Compounds from marine-derived Verrucosispora sp. FIM06054 and their potential antitumour activities.
abstract: Strain FIM06054 was isolated from a marine sponge sample collected from the East China Sea and was characterised as a strain of Verrucosispora genus on the basis of its 16S rRNA gene sequence. One new compound, FW054-1 (1), together with a known aminofuran compound proximicin A (2), was isolated from the culture broth of Verrucosispora sp. FIM06054. Their structures were elucidated on the basis of spectral analysis. 1 and 2 showed antiproliferative activity against several human tumour cell lines.
authors.affiliation: a School of Pharmacy, Fujian Medical University , Fuzhou 350004 , P.R. China.
authors.forename: Nie
authors.initials: N
authors.lastname: Yi-Lei
authors.forename: Wu
authors.initials: W
authors.lastname: Yun-Dan
authors.forename: Wang
authors.initials: W
authors.lastname: Chuan-Xi
authors.forename: Lin
authors.initials: L
authors.lastname: Ru
authors.forename: Xie
authors.initials: X
authors.lastname: Yang
authors.forename: Fang
authors.initials: F
authors.lastname: Dong-Sheng
authors.forename: Jiang
authors.initials: J
authors.lastname: Hong
authors.forename: Lian
authors.initials: L
authors.lastname: Yun-Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D008848:Micromonosporaceae / Q000737:chemistry*; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012266:Ribose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000595390:4-((4-((3,6-dimethyl-2-(hydroxyl)benzoyl)amino)-4-deoxy-3-C-methyl-ribopyranose; D000970:Antineoplastic Agents; D012336:RNA, Ribosomal, 16S; C529559:proximicin A; D009429:Netropsin; D012266:Ribose
keywords: Verrucosispora; antitumour activity; proximicin A