title: APOE polymorphisms and cognitive functions in patients with brain tumors.
abstract: OBJECTIVE
  The goal of this study was to assess whether the APOE ε4 allele and other APOE single nucleotide polymorphisms (SNPs) influence neuropsychological and neuroimaging outcomes in patients with brain tumors.
  
  
  METHODS
  Two hundred eleven patients with brain tumors participated in the study. All patients completed standardized neuropsychological tests and provided a blood sample for APOE genotyping. Ratings of white matter abnormalities were performed on MRI scans. Patients were classified into 2 groups based on the presence (n = 50) or absence (n = 161) of at least one APOE ε4 allele. Additional APOE SNPs were genotyped in a subset of 150 patients.
  
  
  RESULTS
  Patients with at least one APOE ε4 allele had significantly lower scores in verbal learning and delayed recall, and marginally significant lower scores in executive function, in comparison to noncarriers of an ε4 allele. Patients with at least one ε4 allele and history of cigarette smoking had significantly higher scores in working memory and verbal learning than ε4 carriers who never smoked. Nine additional APOE SNPs were significantly associated with attention and executive and memory abilities. There were no significant differences between ε4 carriers and noncarriers on the extent of white matter abnormalities on MRI.
  
  
  CONCLUSIONS
  The findings suggest that patients with brain tumors who are carriers of the APOE ε4 allele may have increased vulnerability to developing memory and executive dysfunction, and that additional SNPs in the APOE gene may be associated with cognitive outcome.
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY. corread@mskcc.org.
authors.forename: Denise D
authors.initials: DD
authors.lastname: Correa
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Jaya
authors.initials: J
authors.lastname: Satagopan
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Baser
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Cheung
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Richards
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Michael
authors.initials: M
authors.lastname: Lin
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Sasan
authors.initials: S
authors.lastname: Karimi
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: John
authors.initials: J
authors.lastname: Lyo
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: DeAngelis
authors.affiliation: From the Departments of Neurology (D.D.C., E.R., L.M.D.), Epidemiology and Biostatistics (J.S., R.E.B., K.C., I.O.), and Radiology (S.K., J.L.), Memorial Sloan-Kettering Cancer Center, New York; and Department of Neurology (D.D.C., M.L., L.M.D.), Weill Cornell Medical College, New York, NY.
authors.forename: Irene
authors.initials: I
authors.lastname: Orlow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D056344:Executive Function; D005260:Female; D060005:Genotyping Techniques; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000235:genetics; D008875:Middle Aged; D015999:Multivariate Analysis; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000009:adverse effects
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E