title: β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
abstract: Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have shown that an optimized cocktail of curcumin and β-cyclodextrin, at appreciably low concentrations, not only inhibited aggregation but also broke up the preformed aggregates almost completely. We propose that these compounds exhibit synergy in their action and thus provide us with the exciting prospect of working toward the development of a suitable drug candidate for prevention and treatment of PD.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Delhi , Hauz Khas, New Delhi 110016, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Gautam
authors.forename: Sandip
authors.initials: S
authors.lastname: Karmakar
authors.forename: Abhik
authors.initials: A
authors.lastname: Bose
authors.forename: Pramit K
authors.initials: PK
authors.lastname: Chowdhury
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D052160:Benzothiazoles; D002942:Circular Dichroism; D003474:Curcumin / Q000737:chemistry*; D004357:Drug Synergism; D005456:Fluorescent Dyes; D013844:Thiazoles; D051844:alpha-Synuclein / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000682:Amyloid; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D013844:Thiazoles; D051844:alpha-Synuclein; D047392:beta-Cyclodextrins; C009462:thioflavin T; D003474:Curcumin; C031215:betadex