title: MITA/STING: a central and multifaceted mediator in innate immune response.
abstract: The recognition of nucleic acids is a general strategy used by the host to detect invading pathogens. Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. MITA can act both as a direct sensor of cyclic dinucleotides (CDNs) and as an adaptor for the recruitment of downstream signaling components. In both roles, MITA is part of signaling cascades that orchestrate innate immune defenses against various pathogens, including viruses, bacteria and parasites. Here, we highlight recent studies that have uncovered the molecular mechanisms of MITA-mediated signal transduction and regulation, and discuss some notable issues that remain elusive.
authors.affiliation: Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, Wuhan 430072, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ran
authors.affiliation: College of Life Sciences, Wuhan University, Wuhan 430072, China.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Shu
authors.affiliation: Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address: wangyy@wh.iov.cn.
authors.forename: Yan-Yi
authors.initials: YY
authors.lastname: Wang
mesh_terms: D000818:Animals; D004247:DNA / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008565:Membrane Proteins / Q000276:immunology*; D012313:RNA / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D000099197:STING Protein
chemical_list: D004247:DNA; D008565:Membrane Proteins; D012313:RNA; C532857:STING1 protein, human; D000099197:STING Protein
keywords: DNA sensor; Innate immune response; MITA; cGAMP