title: Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides.
abstract: We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used to modulate their function or introduce useful side-chains such as fluorophores and photo-crosslinking groups.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056, Basel, Switzerland. dennis.gillingham@unibas.ch.
authors.forename: Na
authors.initials: N
authors.lastname: Fei
authors.forename: Daniel
authors.initials: D
authors.lastname: Häussinger
authors.forename: Seraina
authors.initials: S
authors.lastname: Blümli
authors.forename: Benoît-Joseph
authors.initials: BJ
authors.lastname: Laventie
authors.forename: Lorenzo D
authors.initials: LD
authors.lastname: Bizzini
authors.forename: Kaspar
authors.initials: K
authors.lastname: Zimmermann
authors.forename: Urs
authors.initials: U
authors.lastname: Jenal
authors.forename: Dennis
authors.initials: D
authors.lastname: Gillingham
mesh_terms: D002384:Catalysis; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D011687:Purines / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*
chemical_list: D015226:Dinucleoside Phosphates; D011687:Purines; C030011:carbene; D012211:Rhenium; D008697:Methane