title: Correlation of clinico-pathologic and radiologic parameters of response to neoadjuvant chemotherapy in breast cancer.
abstract: BACKGROUND
  As of today, there is no validated standard method to assess clinical response of breast cancer to neo- adjuvant chemotherapy (NACT). Some centers use clinical dimensions while others use radiological measurements to evaluate response according to RECIST criteria.
  
  
  OBJECTIVE
  The aim was to correlate and compare the clinical, radiological, and pathological parameters for assessing the tumor response in patients of breast cancer receiving NACT.
  
  
  METHODS
  Single institution, prospective nonrandomized study conducted over a 2-year period.
  
  
  METHODS
  Patients with diagnosed breast cancer were assessed for response to NACT prior to surgery using clinical and radiological techniques. This was correlated with pathological reponse which was assessed by measuring gross dimensions and Miller-Payne grading of response to chemotherapy.
  
  
  METHODS
  Spearman's rho nonparametric.
  
  
  RESULTS
  Fifty two patients completed the evaluation (out of 313 cases of ca breast treated during the same period) with a median age of 52.5 years. We noted a 26.9% clinical complete response (CR) and 19.2% had pathological CR. Clinical evaluation had a sensitivity and specificity of 73.5% and 88.5% respectively compared to 14.2% and 100% respectively for radiological assessment.
  
  
  CONCLUSIONS
  Clinical assessment of response to NACT shows a higher sensitivity compared to radiological assessment. However the overall low sensitivity and specificity rates of clinical assessment mandate a search for a better method of evaluation.
authors.forename: P
authors.initials: P
authors.lastname: Mukherjee
authors.affiliation: Department of Surgical Oncology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: Z A
authors.initials: ZA
authors.lastname: Sheikh
authors.forename: D K
authors.initials: DK
authors.lastname: Vijaykumar
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D011859:Radiography; D012074:Remission Induction