title: Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.
abstract: The use of anesthetics and sedatives has been suggested to be a contributor to Alzheimer's disease neuropathogenesis. We wanted to address the in vivo relevance of those substances in the Tg2576 Alzheimer's mouse model. Tg7526 mice were anesthesia-sedated for 90 min once a week for 4 weeks. Y maze, Congo Red, and amyloid beta (Aβ) immunochemistry were performed. We did not find any significant change in the navigation behavior of the exposed mice compared to the controls. Significantly less deposition of Aβ in the CA1 area of the hippocampus and frontal cortex of mice exposed to isoflurane, propofol, diazepam, ketamine, and pentobarbital was observed. In the dentate gyrus, Aβ deposition was significantly greater in the group treated with pentobarbital. Congo Red staining evidenced significantly fewer fibrils in the cortex of mice exposed to diazepam, ketamine, or pentobarbital. The adopted repetitive exposure did not cause a significant detriment in Tg7526 mouse.
authors.affiliation: Department of Molecular Pharmacology and Physiology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Quiroga
authors.forename: Rafael E
authors.initials: RE
authors.lastname: Chaparro
authors.forename: Rachel
authors.initials: R
authors.lastname: Karlnoski
authors.forename: Diana
authors.initials: D
authors.lastname: Erasso
authors.forename: Marcia
authors.initials: M
authors.lastname: Gordon
authors.forename: David
authors.initials: D
authors.lastname: Morgan
authors.forename: Gerardo
authors.initials: G
authors.lastname: Bosco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rubini
authors.forename: Andrea
authors.initials: A
authors.lastname: Parmagnani
authors.forename: Antonio
authors.initials: A
authors.lastname: Paoli
authors.forename: Devanand
authors.initials: D
authors.lastname: Mangar
authors.forename: Enrico M
authors.initials: EM
authors.lastname: Camporesi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000700:Analgesics / Q000494:pharmacology*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D003975:Diazepam / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008822:Mice, Transgenic; D010424:Pentobarbital / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D065854:Spatial Navigation / Q000187:drug effects / Q000502:physiology
chemical_list: C545487:APP protein, human; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000700:Analgesics; D000777:Anesthetics; D007649:Ketamine; D007530:Isoflurane; D010424:Pentobarbital; D003975:Diazepam; D015742:Propofol