title: [Progress in early pancreas development and reprogramming of terminally differentiated cells into β cells].
abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the immune system attacks insulin-secreting β cells, thus leading to an absolute deficiency of insulin. Patients must rely on exogenous insulin, which cannot effectively prevent diabetes complications. Generation of insulin-secreting cells by reprogramming of pluripotent stem cells or somatic cells is a potential approach for the treatment of T1DM. These cells can be used for cell therapy and drug screening, and may eventually provide a cure for the disease. Significant progress has been made in generating insulin-secreting cells through the expression of β cell specific transcription factors in stem cells or somatic cells. In this review, we summarize recent research progress in early pancreas development, β cell specific transcription factors and reprogramming of terminally differentiated cells into β cells.
authors.affiliation: College of Animal Science, Qingdao Agricultural University, Qingdao 266109, China.
authors.forename: Cao
authors.initials: C
authors.lastname: Mingjun
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Huansheng
authors.affiliation: College of Animal Science, Qingdao Agricultural University, Qingdao 266109, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Qingjie
authors.affiliation: College of Animal Science, Qingdao Agricultural University, Qingdao 266109, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Hongjun
authors.affiliation: College of Life Science, Qingdao Agricultural University, Qingdao 266109, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000637:transplantation; D010179:Pancreas / Q000166:cytology / Q000254:growth & development*