title: Assessment of sleep-related disorders in children with sickle cell disease.
abstract: Sleep-related disorders (SRDs) are common in sickle cell disease, however, identification may be time-consuming. Simultaneous survey of multiple SRDs utilizing a simplified instrument would facilitate screening. A simplified questionnaire investigating SRDs [sleep-disordered breathing (SDB), restless legs syndrome (RLS), insomnia, parasomnias, and daytime effects of disrupted sleep] was administered to 2-18-year-old children with sickle cell disease. One hundred participants completed this 5-7 minute survey without difficulties: 54 awoke unrefreshed, 41 had short-term insomnia, 30 had sleep-maintenance insomnia, 21 had chronic sleep-onset insomnia, 54 had chronic habitual snoring and 11 met the criteria for RLS. Sleep-maintenance insomnia was associated with increased body mass index (BMI) (p = 0.001), and chronic sleep-onset insomnia was associated with higher hemoglobin (Hb) levels (p = 0.04). Survey-reported symptoms of SRDs were significantly higher than that reported in the general pediatric population. A fast and simplified SRD survey is feasible and suggests a high prevalence of SRDs in children with sickle cell disease.
authors.affiliation: Department of Hematology, St. Jude Children's Research Hospital , Memphis, Tennessee , USA .
authors.forename: Jane S
authors.initials: JS
authors.lastname: Hankins
authors.forename: Nina I
authors.initials: NI
authors.lastname: Verevkina
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Smeltzer
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.forename: Banu
authors.initials: B
authors.lastname: Aygun
authors.forename: Dave F
authors.initials: DF
authors.lastname: Clarke
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*
keywords: Insomnia; obstructive sleep apnea (OSA); parasomnia; restless legs syndrome (RLS)