title: Development of microRNA therapeutics is coming of age.
abstract: MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.
authors.affiliation: Hubrecht Institute, KNAW and University Medical Center, Utrecht, The Netherlands e.vanrooij@hubrecht.eu sk@bio.aau.dk.
authors.forename: Eva
authors.initials: E
authors.lastname: van Rooij
authors.affiliation: Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Department of Haematology, Aalborg University Hospital, Aalborg, Denmark e.vanrooij@hubrecht.eu sk@bio.aau.dk.
authors.forename: Sakari
authors.initials: S
authors.lastname: Kauppinen
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000628:therapy*; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D016174:Hepacivirus / Q000502:physiology; D006526:Hepatitis C / Q000235:genetics / Q000628:therapy*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D035683:MicroRNAs; D016376:Oligonucleotides, Antisense
keywords: antimiR; miRNA; mimic; therapeutics