title: Synthesis and characterization of metal complexes of Schiff base ligand derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine.
abstract: The Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine were synthesized. These compounds were characterized by elemental analysis, IR, mass, (1)H NMR, electronic spectra, magnetic moment, molar conductance, thermal analysis, powder XRD and SEM. The analytical data show that the metal to ligand ratio is 1:1. The IR results show that the ligand acts as a bidentate donor coordinating through the azomethine nitrogen and imidazole nitrogen atoms. From the electronic spectra and magnetic moment value predicts the geometry of the complexes. The surface morphology of the compounds was studied by SEM. The compounds were screened for their antibacterial activity and antifungal activity using Kirby Bayer disc diffusion method. The DNA cleavage and superoxide dismutase activities of the compounds were investigated. The anticancer activities of the complexes have been carried out towards HeLa and HCT116 cancer cells.
authors.affiliation: Department of Chemistry, St. John's College, Anchal, Kollam 691 306, India. Electronic address: rsjoseyphus@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Selwin Joseyphus
authors.affiliation: Department of Chemistry, St. John's College, Anchal, Kollam 691 306, India.
authors.forename: C
authors.initials: C
authors.lastname: Shiju
authors.affiliation: Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil 629 180, India.
authors.forename: J
authors.initials: J
authors.lastname: Joseph
authors.affiliation: Department of Chemistry, University College of Engineering, Anna University, Nagercoil 629 004, India.
authors.forename: C
authors.initials: C
authors.lastname: Justin Dhanaraj
authors.affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli 627 012, India.
authors.forename: D
authors.initials: D
authors.lastname: Arish
mesh_terms: D000675:Ampyrone / Q000737:chemistry* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D019216:Metals, Heavy / Q000737:chemistry* / Q000494:pharmacology; D009181:Mycoses / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D012545:Schiff Bases / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007093:Imidazoles; D019216:Metals, Heavy; D012545:Schiff Bases; D000675:Ampyrone; C029899:imidazole
keywords: Anticancer; DNA cleavage; Electronic; IR; SEM; Schiff base