title: Mannose metabolism: more than meets the eye.
abstract: Mannose is a simple sugar with a complex life. It is a welcome therapy for genetic and acquired human diseases, but it kills honeybees and blinds baby mice. It could cause diabetic complications. Mannose chemistry, metabolism, and metabolomics in cells, tissues and mammals can help explain these multiple systemic effects. Mannose has good, bad or ugly outcomes depending on its steady state levels and metabolic flux. This review describes the role of mannose at cellular level and its impact on organisms.
authors.affiliation: Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. Electronic address: vsharma@sanfordburnham.org.
authors.forename: Vandana
authors.initials: V
authors.lastname: Sharma
authors.affiliation: Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
authors.forename: Mie
authors.initials: M
authors.lastname: Ichikawa
authors.affiliation: Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
authors.forename: Hudson H
authors.initials: HH
authors.lastname: Freeze
mesh_terms: D000818:Animals; D018981:Congenital Disorders of Glycosylation / Q000178:diet therapy / Q000235:genetics / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D008358:Mannose / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008359:Mannose-6-Phosphate Isomerase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D064688:Metabolic Flux Analysis; D053858:Metabolic Networks and Pathways; D055432:Metabolomics; D051379:Mice; D017875:Phosphotransferases (Phosphomutases) / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism; D011247:Pregnancy; D015027:Zebrafish
chemical_list: D004040:Dietary Carbohydrates; D011134:Polysaccharides; D008359:Mannose-6-Phosphate Isomerase; D017875:Phosphotransferases (Phosphomutases); D008358:Mannose
keywords: Congenital disorders of glycosylation; Mannose; Metabolism; N-glycosylation; Phosphomannomutase; Phosphomannose isomerase