title: CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients.
abstract: Colorectal cancer (CRC) is an epidemiological problem of a great importance in Poland; each year approximately 14,600 new cases of the disease are diagnosed. Mortality associated with CRC reaches approximately 10,400 cases per year (according to the National Cancer Registry). The 5-year survival rate is approximately 25 %, which is one of the lowest rates in Europe. The etiology of sporadic colorectal cancer (CRC) is multifactorial and has been attributed to an interplay between both environmental and genetic risk factors. In addition, there is a general consensus that genetic factors may modulate the influence of environmental insults. Following these assumptions, we performed a study on widely described polymorphisms in xenobiotic-metabolizing enzymes and DNA repair genes which may influence individual susceptibility to cancer. We selected five candidate polymorphisms in following genes: ERCC1 Asp118Asn (rs11615), XPC i11C/A (rs2279017), XRCC3 Met241Thr (rs861539) CYP1A1 Ile462Val (rs1048943) and NAT2 A803G (rs1208) and assessed the importance of chosen SNPs on groups consisting of 478 CRC patients and 404 controls. Only CYP1A1 Ile462Val was statistically significant in CRC patients over 50 years old: OR 2.05 (1.29-3.28); p = 1.25E-02 and this association was more pronounced in the female group of CRC patients after the age of 50: OR 2.72 (1.43-5.14); p = 1.14E-02.
authors.affiliation: Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1, 50-368, Wroclaw, Poland, justyna.gil@umed.wroc.pl.
authors.forename: Justyna
authors.initials: J
authors.lastname: Gil
authors.forename: Paweł
authors.initials: P
authors.lastname: Gaj
authors.forename: Błażej
authors.initials: B
authors.lastname: Misiak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Ostrowski
authors.forename: Pawel
authors.initials: P
authors.lastname: Karpinski
authors.forename: Alicja
authors.initials: A
authors.lastname: Jarczyńska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kielan
authors.forename: Maria Malgorzata
authors.initials: MM
authors.lastname: Sasiadek
mesh_terms: D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D004720:Endonucleases / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3; C086984:XPC protein, human; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human; C071447:ERCC1 protein, human; D004720:Endonucleases