title: Effects of lateral amygdala lesions on the responses to novelty in mice.
abstract: Bilateral electrolytic lesions restricted to the lateral, basolateral and basomedial amygdaloid nuclei in mice produced a lack of avoidance responses towards novel stimuli. While controls showed avoidance and burying reactions to a novel object introduced into their familiar environment, lesioned mice displayed a high number of approach responses and a low level of burying reactions. Furthermore, when given the opportunity to move around freely in simultaneously presented novel and familiar places, control mice at first exhibited avoidance reactions to the novel environment before showing novelty preference. There were no avoidance reactions in lesioned mice. These data are consistent with the hypothesis that amygdala plays a specific role in the regulation of defensive reactions.
authors.affiliation: Laboratoire de Psychophysiologie, 7, rue de l'Université, 67000 Strasbourg France.
authors.forename: R
authors.initials: R
authors.lastname: Misslin
authors.forename: P
authors.initials: P
authors.lastname: Ropartz