title: Pancreatic cancer stroma: friend or foe?
abstract: Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that responds to checkpoint blockade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.
authors.affiliation: Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN 46202, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Gore
authors.affiliation: Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN 46202, USA. Electronic address: mkorc@iu.edu.
authors.forename: Murray
authors.initials: M
authors.lastname: Korc
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology*