title: Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS).
abstract: OBJECTIVE
  Although adiponectin is a major adipocytokine that affects the pathogenesis of various cardiovascular diseases, its clinical significance in stroke remains controversial. We investigated the clinical significance of plasma adiponectin for the diagnosis, neurological severity and functional outcomes of patients with ischemic stroke.
  
  
  METHODS
  We prospectively enrolled 171 patients with ischemic stroke and 171 age- and sex-matched healthy controls. Blood samples and clinical information were obtained at day 0, 3, 7, 14 and 90 after stroke onset.
  
  
  RESULTS
  Average adiponectin values at day 0 did not significantly differ between the controls and the patients, but were significantly lower and higher in patients with atherothrombotic brain (ATBI) (p=0.047) and cardioembolic (CE) (p=0.008) infarction, respectively, than in the controls. Multivariate logistic regression analyses showed that the adiponectin value at day 0 could predict ATBI (odds ratio, 0.75; 95% confidence interval, 0.58 to 0.91, p=0.009, per 1-μg/mL increase). Adiponectin values at day 0 were positively associated with neurological severity as evaluated by the National Institute of Health Stroke Scale upon admission (r=0.420, p=0.003) and were higher in the groups with poor outcomes (modified Rankin Scale (mRS) ≥ 3 on day 90) than in those with good ones (mRS ≤ 2) in all stroke subtypes, with statistical significance in ATBI (p=0.015).
  
  
  CONCLUSIONS
  Plasma adiponectin values may help to classify stroke subtypes and predict neurological severity and functional outcome in ischemic stroke patients.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; Department of Cerebrovascular Medicine and Neurology, Cerebrovascular Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka. Electronic address: kuwashiro@kyumed.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kuwashiro
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka. Electronic address: agou@intmed2.med.kyushu-u.ac.jp.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kamouchi
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Ryu
authors.initials: R
authors.lastname: Matsuo
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Jun
authors.initials: J
authors.lastname: Hata
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.affiliation: Department of Cerebrovascular Disease, St. Mary's Hospital, Fukuoka.
authors.forename: Kenji
authors.initials: K
authors.lastname: Fukuda
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugimori
authors.affiliation: Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Masayo
authors.initials: M
authors.lastname: Fukuhara
authors.affiliation: Molecuence Corporation, Tokyo, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Awano
authors.affiliation: Molecuence Corporation, Tokyo, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Isomura
authors.affiliation: Molecuence Corporation, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Cerebrovascular Medicine and Neurology, Cerebrovascular Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasaka
authors.affiliation: Department of Cerebrovascular Medicine and Neurology, Cerebrovascular Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
authors.affiliation: Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000503:physiopathology; D020520:Brain Infarction / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D059409:Stroke, Lacunar / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; Biomarkers; Functional outcome; Ischemic stroke; Stroke subtype