title: A systems biology approach to study the biology characteristics of esophageal squamous cell carcinoma by integrating microRNA and messenger RNA expression profiling.
abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors. The aim of this study was to investigate the biology characteristics of ESCC by analyzing microRNA and mRNA expression profile. We used BRB-array tools to analyze the deregulated microRNA and mRNA between esophageal squamous cell carcinomas and paired normal adjacent tissues. We used miRTrail and protein-protein interaction methods to explore the related pathways and networks of deregulated microRNA and mRNA. By combining the results of pathways and networks, we found that the deregulated microRNA and their deregulated target mRNA are enriched in the following pathways: DNA replication, cell cycle, ECM-receptor interaction, focal adhesion, mismatch repair, and pathways in cancer. The results showed that many deregulated microRNAs and mRNAs may play a vital role in the pathogenesis of ESCC, and the systems biology approach is very helpful to explore molecular mechanism of ESCC.
authors.affiliation: Oncology Center, ZhuJiang Hospital, Southern Medical University, Guangzhou, 510282, China.
authors.forename: Xufeng
authors.initials: X
authors.lastname: Li
authors.forename: Chunyu
authors.initials: C
authors.lastname: Jiang
authors.forename: Xiaocong
authors.initials: X
authors.lastname: Wu
authors.forename: Yao
authors.initials: Y
authors.lastname: Sun
authors.forename: Junguo
authors.initials: J
authors.lastname: Bu
authors.forename: Jiqiang
authors.initials: J
authors.lastname: Li
authors.forename: Mingxing
authors.initials: M
authors.lastname: Xiao
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jiren
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D025941:Protein Interaction Mapping; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D049490:Systems Biology
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger