title: Detection of white matter injury in concussion using high-definition fiber tractography.
abstract: Over the last few decades, structural imaging techniques of the human brain have undergone significant strides. High resolution provided by recent developments in magnetic resonance imaging (MRI) allows improved detection of injured regions in patients with moderate-to-severe traumatic brain injury (TBI). In addition, diffusion imaging techniques such as diffusion tensor imaging (DTI) has gained much interest recently due to its possible utility in detecting structural integrity of white matter pathways in mild TBI (mTBI) cases. However, the results from recent DTI studies in mTBI patients remain equivocal. Also, there are important shortcomings for DTI such as limited resolution in areas of multiple crossings and false tract formation. The detection of white matter damage in concussion remains challenging, and development of imaging biomarkers for mTBI is still in great need. In this chapter, we discuss our experience with high-definition fiber tracking (HDFT), a diffusion spectrum imaging-based technique. We also discuss ongoing developments and specific advantages HDFT may offer concussion patients.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pa., USA.
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Shin
authors.forename: Sudhir
authors.initials: S
authors.lastname: Pathak
authors.forename: Nora
authors.initials: N
authors.lastname: Presson
authors.forename: William
authors.initials: W
authors.lastname: Bird
authors.forename: Lauren
authors.initials: L
authors.lastname: Wagener
authors.forename: Walter
authors.initials: W
authors.lastname: Schneider
authors.forename: David O
authors.initials: DO
authors.lastname: Okonkwo
authors.forename: Juan C
authors.initials: JC
authors.lastname: Fernandez-Miranda
mesh_terms: D001924:Brain Concussion / Q000473:pathology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D066127:White Matter / Q000293:injuries / Q000473:pathology*