title: Effect of glatiramer acetate on peripheral blood brain-derived neurotrophic factor and phosphorylated TrkB levels in relapsing-remitting multiple sclerosis.
abstract: Glatiramer acetate (GA) is one of the most widely used disease-modifying drugs for the treatment of relapsing-remitting multiple sclerosis; is assumed to have inductor effects on neurotrophic factor expression. One of these neurotrophic factor systems is the brain-derived neurotrophic factor (BDNF)/receptor tyrosine kinase B (TrkB) pathway. Peripheral blood is thought to contain soluble BDNF, and some blood cells express TrkB. We attempted to determine whether GA treatment leads to changes in plasma BDNF levels and TrkB activation. Such a phenomenon are relapsing-remitting multiple sclerosis patients is significantly reduced; GA treatment is not influencing peripheral BDNF levels, after one year of sustained therapy, not from the point of view of total free BDNF nor the phosphorylated TrkB.
authors.forename: Vitalie
authors.initials: V
authors.lastname: Vacaras
authors.forename: Zsigmond Z
authors.initials: ZZ
authors.lastname: Major
authors.forename: Dafin F
authors.initials: DF
authors.lastname: Muresanu
authors.forename: Tibor L
authors.initials: TL
authors.lastname: Krausz
authors.forename: Ioan
authors.initials: I
authors.lastname: Marginean
authors.affiliation: Department of Clinical Neurosciences, University of Medicine and Pharmacy "Iuliu Hatieganu", Victor Babeș Street No. 8, 400012 Cluj-Napoca, Romania. dafinm@ssnn.ro.
authors.forename: Dana A
authors.initials: DA
authors.lastname: Buzoianu
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use*; D010766:Phosphorylation / Q000187:drug effects; D011505:Protein-Tyrosine Kinases / Q000097:blood*; D020813:Receptor, trkB; D013997:Time Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D010455:Peptides; D000068717:Glatiramer Acetate; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human