title: Titanium dioxide-montmorillonite nanocomposite as photoprotective agent against ultraviolet B radiation-induced mutagenesis in Saccharomyces cerevisiae: a potential candidate for safer sunscreens.
abstract: Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2 ), and montmorillonite (MMT) upon ultraviolet B (UVB) irradiation, alone and in different associations [physical mixtures (PMs)], were evaluated using a Saccharomyces cerevisiae ogg1 mutant (deficient) strain. In addition, we developed and characterized a delaminated TiO2-pillared MMT, called the TiO2 -MMT nanocomposite (NC), which was also investigated in terms of its photoprotective and mutagenic potential. Overall, our results revealed an interesting TiO2 -MMT NC endowed with antimutagenic activity that can be associated to organic sunscreen molecule (ODP) and still maintain its positive effect, whereas its respective PM is unable to grant antimutagenic protection against UVB.
authors.affiliation: Laboratório de Radiobiologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil; Laboratório de Microbiologia e Avaliação Genotóxica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil.
authors.forename: Juliana P
authors.initials: JP
authors.lastname: Paiva
authors.forename: Bianca A M C
authors.initials: BA
authors.lastname: Santos
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Kibwila
authors.forename: Tula C W
authors.initials: TC
authors.lastname: Gonçalves
authors.forename: A Viviana
authors.initials: AV
authors.lastname: Pinto
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Rodrigues
authors.forename: Alvaro C
authors.initials: AC
authors.lastname: Leitão
authors.forename: Lúcio M
authors.initials: LM
authors.lastname: Cabral
authors.forename: Marcelo
authors.initials: M
authors.lastname: De Pádula
mesh_terms: D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D001546:Bentonite / Q000737:chemistry / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D053761:Nanocomposites / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects*; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology*; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D016587:Antimutagenic Agents; D013473:Sunscreening Agents; D001546:Bentonite; C009495:titanium dioxide; D014025:Titanium
keywords: UVB; X-ray diffraction; cerevisiae; clays; layered compounds; montmorillonite; mutagenesis; nanocomposite; nanostructures, nanotechnology; titanium dioxide