title: Sirolimus-related systemic thrombotic microangiopathy after renal transplantation.
abstract: We describe the case of a renal transplant patient who developed de novo biopsy-proven thrombotic microangiopathy (TMA) and deep venous thrombosis after treatment with sirolimus (SRL). We discuss the clinical course, diagnosis and therapeutics of this patient in the context of the literature.
authors.affiliation: Centre de Recherche clinique Paris-Sud, Le Kremlin-Bicêtre, France.
authors.forename: Simone
authors.initials: S
authors.lastname: Negrini
authors.affiliation: Service de Néphrologie, Dialyse et Transplantation, IFRNT, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Durrbach
authors.affiliation: Centre de Recherche clinique Paris-Sud, Le Kremlin-Bicêtre, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
mesh_terms: D000368:Aged; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D020123:Sirolimus / Q000008:administration & dosage / Q000009:adverse effects*; D057049:Thrombotic Microangiopathies / Q000139:chemically induced* / Q000175:diagnosis; D019172:Transplantation Conditioning / Q000009:adverse effects; D020246:Venous Thrombosis / Q000139:chemically induced / Q000175:diagnosis
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus