title: Quantifying cerebellum grey matter and white matter perfusion using pulsed arterial spin labeling.
abstract: To facilitate quantification of cerebellum cerebral blood flow (CBF), studies were performed to systematically optimize arterial spin labeling (ASL) parameters for measuring cerebellum perfusion, segment cerebellum to obtain separate CBF values for grey matter (GM) and white matter (WM), and compare FAIR ASST to PICORE. Cerebellum GM and WM CBF were measured with optimized ASL parameters using FAIR ASST and PICORE in five subjects. Influence of volume averaging in voxels on cerebellar grey and white matter boundaries was minimized by high-probability threshold masks. Cerebellar CBF values determined by FAIR ASST were 43.8 ± 5.1 mL/100 g/min for GM and 27.6 ± 4.5 mL/100 g/min for WM. Quantitative perfusion studies indicated that CBF in cerebellum GM is 1.6 times greater than that in cerebellum WM. Compared to PICORE, FAIR ASST produced similar CBF estimations but less subtraction error and lower temporal, spatial, and intersubject variability. These are important advantages for detecting group and/or condition differences in CBF values.
authors.affiliation: Department of Radiology and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, MN 55455, USA.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Subhendra N
authors.initials: SN
authors.lastname: Sarkar
authors.affiliation: Siemens Healthcare, Malvern, PA 19355, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Purdy
authors.affiliation: Department of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USA ; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA ; Department of Physics & Astronomy, Georgia State University, Atlanta, GA 30302, USA.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Briggs
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002531:Cerebellum / Q000098:blood supply / Q000000981:diagnostic imaging; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D011673:Pulsatile Flow / Q000502:physiology; D011859:Radiography; D013113:Spin Labels
chemical_list: D013113:Spin Labels