title: Glyaderm(®) dermal substitute: clinical application and long-term results in 55 patients.
abstract: BACKGROUND
  Glycerol preserved acellular dermis (Glyaderm(®)) consists of collagen and elastin fibers and is the first non-profit dermal substitute derived from glycerol-preserved, human allogeneic skin. It is indicated for bi-layered skin reconstruction of full thickness wounds.
  
  
  METHODS
  A protocol for clinical application and optimal interval before autografting with split thickness skin graft (STSG) was developed in a pilot study. A phase III randomized, controlled, paired, intra-individual study compared full thickness defects engrafted with Glyaderm(®) and STSG versus STSG alone. Outcome measures included percentage of Glyaderm(®) take, STSG take, and scar quality assessment.
  
  
  RESULTS
  Pilot study (27 patients): Mean take rates equaled 91.55% for Glyaderm(®) and 96.67% for STSG. The optimal autografting interval was 6 days (±1 day). Randomized trial (28 patients): Mean Glyaderm(®) take rate was 88.17%. STSG take rates were comparable for both research groups (p=0.588). One year after wound closure, Glyaderm(®)+STSG was significantly more elastic (p=0.003) than STSG alone. Blinded observers scored Glyaderm(®) treated wounds better in terms of scar quality.
  
  
  CONCLUSIONS
  The efficacy of Glyaderm(®) as a suitable dermal substitute for full thickness wounds is attested. Currently a procedure for simultaneous application of Glyaderm(®) and STSG is adopted, allowing for further widespread use of Glyaderm(®).
authors.affiliation: Department of Plastic and Reconstructive Surgery, Burn Center, Ghent University Hospital, Ghent, Belgium.
authors.forename: Ali
authors.initials: A
authors.lastname: Pirayesh
authors.affiliation: Department of Plastic and Reconstructive Surgery, Burn Center, Ghent University Hospital, Ghent, Belgium.
authors.forename: Henk
authors.initials: H
authors.lastname: Hoeksema
authors.affiliation: Department of Molecular Cell Biology and Immunology, Medical Faculty, Vrije Universiteit Medical Center, Amsterdam, The Netherlands; Euro Skin Bank, Beverwijk, The Netherlands.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Richters
authors.affiliation: Department of Plastic and Reconstructive Surgery, Burn Center, Ghent University Hospital, Ghent, Belgium.
authors.forename: Jozef
authors.initials: J
authors.lastname: Verbelen
authors.affiliation: Department of Plastic and Reconstructive Surgery, Burn Center, Ghent University Hospital, Ghent, Belgium. Electronic address: Stan.Monstrey@UGent.be.
authors.forename: Stan
authors.initials: S
authors.lastname: Monstrey
mesh_terms: D062088:Acellular Dermis; D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix; D004548:Elasticity; D006801:Humans; D007223:Infant; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D010865:Pilot Projects; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D016038:Skin Transplantation; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
keywords: Acellular dermal matrix; Dermal substitute; Full thickness burn; Glyaderm(®); Skin substitute