title: The search for antiaging interventions: from elixirs to fasting regimens.
abstract: The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.
authors.affiliation: Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. Electronic address: decabora@mail.nih.gov.
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria.
authors.forename: Didac
authors.initials: D
authors.lastname: Carmona-Gutierrez
authors.affiliation: Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: Michel
authors.initials: M
authors.lastname: Bernier
authors.affiliation: Biozentrum, University of Basel, Basel 4056, Switzerland.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Hall
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria. Electronic address: frank.madeo@uni-graz.at.
authors.forename: Frank
authors.initials: F
authors.lastname: Madeo
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001343:Autophagy; D004032:Diet; D015444:Exercise; D006801:Humans; D008136:Longevity / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D000975:Antioxidants