title: Psychological states, serum markers and survival: associations and predictors of survival in patients with renal cell carcinoma.
abstract: This study sought to determine if there was an association between prognostic-based serum biomarkers, survival, and psychosocial factors in patients with metastatic renal cell carcinoma. Associations were found between psychosocial factors and biomarker levels (hemoglobin with depressive symptoms (r = -0.29), positive affect (r = 0.30), social support (r = 0.19), and perceived stress (r = -0.27); albumin with depressive symptoms (r = -0.19), positive affect (r = 0.22), and social support (r = 0.20); alkaline phosphatase with depressive symptoms (r = 0.21), all p values <0.05. After adjustment for disease-related risk factors, only the associations between positive affect and perceived stress with hemoglobin remained significant (p's < 0.05). Positive affect (HR = 0.90; 95% CI = 0.83, 0.97; p = 0.009) and depressive symptom total scores (HR = 1.03; 95% CI = 1.01, 1.06; p = 0.013), and alkaline phosphatase (HR 2.72; 95% CI = 1.41, 5.24; p = 0.003) were associated with survival. This study suggests that measures of positive and negative psychological outlook may contribute differently to health, well-being, and survival.
authors.affiliation: Unit 410, Department of General Oncology and the Integrative Medicine Program, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77230, USA, SPrinsloo@mdanderson.org.
authors.forename: Sarah
authors.initials: S
authors.lastname: Prinsloo
authors.forename: Qi
authors.initials: Q
authors.lastname: Wei
authors.forename: Shellie M
authors.initials: SM
authors.lastname: Scott
authors.forename: Nizar
authors.initials: N
authors.lastname: Tannir
authors.forename: Eric
authors.initials: E
authors.lastname: Jonasch
authors.forename: Louis
authors.initials: L
authors.lastname: Pisters
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000523:psychology*; D003863:Depression / Q000097:blood; D005260:Female; D006454:Hemoglobins; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D012944:Social Support; D013315:Stress, Psychological / Q000097:blood; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D012709:Serum Albumin; D000469:Alkaline Phosphatase