title: Predictive role of the neutrophil lymphocyte ratio for invasion with gestational trophoblastic disease.
abstract: OBJECTIVE
  The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR) for invasion of gestational trophoblastic disease (GTD).
  
  
  METHODS
  A retrospective analysis was conducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion according to histological examination. The clinical parameters of patients with invasive GTD (Group 1; n=8) were compared with patients who showed no invasion (Group 2; n=119). All underwent a prior uterine evacuation and followed up by regular assessment of β-hCG titers.
  
  
  RESULTS
  Demographic and obstetric history and pre-evacuation hCG levels of the patients showed no statistically significantly difference between the groups (p>0.05). The mean gestational weeks (GW), size of the GTD and NLR levels were statistically significantly higher in the invasive GTD group (p<0.05). Correlations between invasion and gestational weeks, size of GTD, post-evacuation chemotherapy and NLR were evident. ROC curve analysis demonstrated that GW, size of GTD and NLR may be discriminative parameters in predicting invasion of GTD.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first study evaluating the predictive role of NLR in invasion of GTD. In conclusion, we think that pretreatment NLR can be used as a biomarker of invasion in GTD.
authors.affiliation: Department of Obstetrics and Gynecology; Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital, Ankara, Turkey E-mail : aliirfanguzel77@gmail.com.
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Guzel
authors.forename: Mahmut Kuntay
authors.initials: MK
authors.lastname: Kokanali
authors.forename: Selcuk
authors.initials: S
authors.lastname: Erkilinc
authors.forename: Hasan Onur
authors.initials: HO
authors.lastname: Topcu
authors.forename: Murat
authors.initials: M
authors.lastname: Oz
authors.forename: Emre
authors.initials: E
authors.lastname: Ozgu
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000473:pathology*; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D009504:Neutrophils; D011247:Pregnancy; D011248:Pregnancy Complications; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers