title: Comparative genomics of Mycobacterium tuberculosis drug efflux pumps and their transcriptional regulators.
abstract: Efflux pump systems are important in general drug resistance. Understanding efflux pumps can inform drug target selection and novel antibiotics designs. In this review, we have summarized the physiological roles, types, and mechanisms of drug efflux pumps. Mycobacterium tuberculosis is the causative agent of tuberculosis, a global threat to public health, and the increasing resistance of this mycobacterium to antibiotics is alarming. Therefore, we have focused on the comparative genomics of efflux pumps and relevant transcriptional regulators of M. tuberculosis.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Southwest University.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D023281:Genomics; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D014158:Transcription, Genetic; D014376:Tuberculosis / Q000188:drug therapy / Q000235:genetics* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins