title: Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease.
abstract: Inflammatory bowel diseases (IBD) are chronic, relapsing conditions of multifactorial etiology. The two primary diseases of IBD are Crohn's disease (CD) and ulcerative colitis (UC). Both entities are hypothesized to occur in genetically susceptible individuals due to microbial alterations and environmental contributions. The exact etiopathogenesis, however, is not known for either disease. A variety of mouse models of CD and UC have been developed to investigate the pathogenesis of these diseases and evaluate treatment modalities. Broadly speaking, the mouse models can be divided into 4 categories: genetically engineered, immune manipulated, spontaneous and erosive/chemically induced. No one mouse model completely recapitulates the immunopathology of CD or UC, however each model possesses particular similarities to human IBD and offers advantageous for specific details of IBD pathogenesis. Here we discuss the more commonly used models in each category and critically evaluate how the immunopathology induced compares to CD or UC, as well as the advantages and disadvantages associated with each model.
authors.affiliation: Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47906, United States. Electronic address: yljones@purdue.edu.
authors.forename: Yava L
authors.initials: YL
authors.lastname: Jones-Hall
authors.affiliation: Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, United States.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Grisham
keywords: Colitis; Crohn's disease; Inflammatory bowel disease; Mouse model; Mouse pathology; Ulcerative colitis