title: Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies.
abstract: Lung cancer is responsible for over one million deaths worldwide each year. Smoking cessation for lung cancer prevention remains key, but it is increasingly acknowledged that prevention strategies also need to focus on high-risk groups, including ex-smokers, and patients who have undergone resection of a primary tumor. Models for chemoprevention of lung cancer often present conflicting results, making rational design of lung cancer chemoprevention trials challenging. There has been much focus on use of dietary bioactive compounds in lung cancer prevention strategies, primarily due to their favorable toxicity profile and long history of use within the human populace. One such compound is curcumin, derived from the spice turmeric. This review summarizes and stratifies preclinical evidence for chemopreventive efficacy of curcumin in models of lung cancer, and adjudges the weight of evidence for use of curcumin in lung cancer chemoprevention strategies.
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom lh28@le.ac.uk.
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Howells
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
authors.forename: Jagdish
authors.initials: J
authors.lastname: Mahale
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
authors.forename: Stewart
authors.initials: S
authors.lastname: Sale
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
authors.forename: Laura
authors.initials: L
authors.lastname: McVeigh
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
authors.forename: William P
authors.initials: WP
authors.lastname: Steward
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
authors.forename: Anne
authors.initials: A
authors.lastname: Thomas
authors.affiliation: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
authors.forename: Karen
authors.initials: K
authors.lastname: Brown
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D045744:Cell Line, Tumor; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*; D019317:Evidence-Based Medicine / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D011322:Primary Prevention / Q000379:methods*; D055502:Secondary Prevention / Q000379:methods*; D016540:Smoking Cessation / Q000379:methods; D055512:Tertiary Prevention / Q000379:methods*; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D003474:Curcumin