title: Adipose tissue changes in obesity and the impact on metabolic function.
abstract: Obesity is associated with adverse alterations in adipose tissue that predispose to metabolic dysregulation. These adverse alterations include accumulation of inflammatory macrophages leading to the activation of inflammation pathways, reduction in lipid turnover, and deposition of fat in ectopic locations. These alterations are precursors to the development of insulin resistance and metabolic dysfunction.
authors.affiliation: Department of Medicine, Section of Endocrinology, Pritzker School of Medicine, University of Chicago, Chicago, Ill. Electronic address: ssam@medicine.bsd.uchicago.edu.
authors.forename: Susan
authors.initials: S
authors.lastname: Sam
authors.affiliation: Department of Medicine, NorthShore University Health System, Pritzker School of Medicine, University of Chicago, Chicago, Ill.
authors.forename: Theodore
authors.initials: T
authors.lastname: Mazzone
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009765:Obesity / Q000378:metabolism*