title: Functional gene variants of CYP3A4.
abstract: Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for patients. This review article highlights the functional consequences of all CYP3A4 variants recognized by the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
authors.affiliation: Institute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
authors.forename: A N
authors.initials: AN
authors.lastname: Werk
authors.affiliation: Institute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Cascorbi
mesh_terms: D051544:Cytochrome P-450 CYP3A / Q000235:genetics* / Q000378:metabolism*; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000201:enzymology / Q000235:genetics; D005838:Genotype; D006801:Humans; D061214:Patient Safety; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human