title: Circadian regulation of metabolism.
abstract: In association with sleep-wake and fasting-feeding cycles, organisms experience dramatic oscillations in energetic demands and nutrient supply. It is therefore not surprising that various metabolic parameters, ranging from the activity status of molecular energy sensors to circulating nutrient levels, oscillate in time-of-day-dependent manners. It has become increasingly clear that rhythms in metabolic processes are not simply in response to daily environmental/behavioral influences, but are driven in part by cell autonomous circadian clocks. By synchronizing the cell with its environment, clocks modulate a host of metabolic processes in a temporally appropriate manner. The purpose of this article is to review current understanding of the interplay between circadian clocks and metabolism, in addition to the pathophysiologic consequences of disruption of this molecular mechanism, in terms of cardiometabolic disease development.
authors.affiliation: Division of Molecular and Cellular PathologyDepartment of PathologyDivision of Cardiovascular DiseasesDepartment of Medicine, University of Alabama at Birmingham, 703 19th Street South, ZRB 308, Birmingham, Alabama 35294, USA.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Bailey
authors.affiliation: Division of Molecular and Cellular PathologyDepartment of PathologyDivision of Cardiovascular DiseasesDepartment of Medicine, University of Alabama at Birmingham, 703 19th Street South, ZRB 308, Birmingham, Alabama 35294, USA.
authors.forename: Uduak S
authors.initials: US
authors.lastname: Udoh
authors.affiliation: Division of Molecular and Cellular PathologyDepartment of PathologyDivision of Cardiovascular DiseasesDepartment of Medicine, University of Alabama at Birmingham, 703 19th Street South, ZRB 308, Birmingham, Alabama 35294, USA meyoung@uab.edu.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Young
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000117:Acetylglucosamine / Q000378:metabolism; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000428:Alcohol Drinking / Q000009:adverse effects; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism / Q000502:physiology; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D003920:Diabetes Mellitus / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D006418:Heme / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008027:Light; D050356:Lipid Metabolism / Q000502:physiology; D008928:Mitochondria / Q000502:physiology; D009243:NAD / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology; D011506:Proteins / Q000378:metabolism; D012890:Sleep; D020178:Sleep Disorders, Circadian Rhythm / Q000503:physiopathology; D013493:Suprachiasmatic Nucleus / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
chemical_list: D000596:Amino Acids; D011506:Proteins; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D006418:Heme; D055372:AMP-Activated Protein Kinases; D000117:Acetylglucosamine
keywords: circadian rhythms; glucose metabolism; lipid; metabolism