title: Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.
abstract: Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.
authors.affiliation: Discovery Chemistry and ‡Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
authors.forename: Olivier
authors.initials: O
authors.lastname: René
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Fauber
authors.forename: Sushant
authors.initials: S
authors.lastname: Malhotra
authors.forename: Herbert
authors.initials: H
authors.lastname: Yajima
mesh_terms: D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006847:Hydrocarbons, Iodinated; D013449:Sulfonamides; D010165:Palladium