title: Severe enterocolitis associated with antiepileptic-induced drug reaction with eosinophilia and systemic symptoms.
abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious drug-induced reaction with cutaneous, hematologic, and solid-organ injury. Antiepileptic drugs are one of the most common classes of drugs implicated in DRESS. A high morbidity and mortality may result, especially if the offending drug is not withdrawn promptly. Although DRESS may involve many organs, severe involvement of the gastrointestinal tract in DRESS and/or in association with antiepileptic drugs has rarely been reported. We report detailed clinical and histopathologic findings of a fatal case of DRESS syndrome resulting from antiepileptic drug treatment that was accompanied by severe enterocolitis, malabsorption, and cachexia.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Swanson
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Low
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095.
authors.forename: Bita V
authors.initials: BV
authors.lastname: Naini
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002100:Cachexia / Q000139:chemically induced; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis*; D004760:Enterocolitis / Q000139:chemically induced*; D004802:Eosinophilia / Q000139:chemically induced*; D017809:Fatal Outcome; D005260:Female; D041981:Gastrointestinal Tract / Q000473:pathology; D006801:Humans; D008286:Malabsorption Syndromes / Q000139:chemically induced; D012640:Seizures / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants
keywords: Antiepileptic drugs; Colitis; Drug reaction with eosinophilia and systemic symptoms; Enteritis; Hypersensitivity