title: Synthesis and antioxidant activity evaluation of new compounds from hydrazinecarbothioamide and 1,2,4-triazole class containing diarylsulfone and 2,4-difluorophenyl moieties.
abstract: In the present investigation, new hydrazinecarbothioamides 4-6 were synthesized by reaction of 4-(4-X-phenylsulfonyl)benzoic acids hydrazides (X=H, Cl, Br) 1-3 with 2,4-difluorophenyl isothiocyanate and further these were treated with sodium hydroxide to obtain 1,2,4-triazole-3-thione derivatives 7-9. The reaction of 7-9 with α-halogenated ketones, in basic media, afforded new S-alkylated derivatives 10-15. The structures of the synthesized compounds have been established on the basis of 1H-NMR, 13C-NMR, IR, mass spectral studies and elemental analysis. The antioxidant activity of all compounds has been screened. Hydrazinecarbothioamides 4-6 showed excellent antioxidant activity and 1,2,4-triazole-3-thiones 7-9 showed good antioxidant activity using the DPPH method.
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania. sbarbuceanu@gmail.com.
authors.forename: Stefania-Felicia
authors.initials: SF
authors.lastname: Barbuceanu
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania. ilies_diana@hotmail.com.
authors.forename: Diana Carolina
authors.initials: DC
authors.lastname: Ilies
authors.affiliation: Pharmaceutical Technology Department, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania. gsaramet@gmail.com.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Saramet
authors.affiliation: General and Inorganic Chemistry Department, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania. valentina_uivarosi@yahoo.com.
authors.forename: Valentina
authors.initials: V
authors.lastname: Uivarosi
authors.affiliation: Nenitescu" Institute of Organic Chemistry, Romanian Academy, 202B Splaiul Independenţei, 060023 Bucharest, Romania. cst_drag@yahoo.com.
authors.forename: Constantin
authors.initials: C
authors.lastname: Draghici
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania. valeria_radulescu@yahoo.com.
authors.forename: Valeria
authors.initials: V
authors.lastname: Radulescu
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D013450:Sulfones / Q000737:chemistry; D013854:Thioamides / Q000138:chemical synthesis / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D006834:Hydrazines; D013450:Sulfones; D013854:Thioamides; D014230:Triazoles; C045575:1,2,4-triazole