title: Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling.
abstract: Oligodendrocytes are myelin-forming glia that ensheath the axons of neurons in the CNS. Recent studies have revealed that Wnt/β-catenin signaling plays important roles in oligodendrocyte development and myelin formation. However, there are conflicting reports on the specific function of Wnt signaling components in oligodendrocyte specification and differentiation. In the present study, we demonstrate that activation of β-catenin in neural progenitor cells before gliogenesis inhibits the generation of oligodendrocyte progenitors (OLPs) in mice. Once OLPs are formed, β-catenin becomes necessary for oligodendrocyte differentiation. Disruption of β-catenin signaling instead leads to a significant delay of oligodendrocyte maturation. These findings suggest that Wnt/β-catenin pathway regulates oligodendrocyte development in a stage-dependent manner.
authors.affiliation: Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of China.
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Dai
authors.affiliation: Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of China.
authors.forename: Shuhui
authors.initials: S
authors.lastname: Sun
authors.affiliation: Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40292, and.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Hu
authors.affiliation: Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of China.
authors.forename: Zunyi
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
authors.forename: Qing Richard
authors.initials: QR
authors.lastname: Lu
authors.affiliation: Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of China, Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40292, and m0qiu001@yahoo.com.
authors.forename: Mengsheng
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009836:Oligodendroglia / Q000502:physiology*; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology*
chemical_list: C495267:CTNNB1 protein, mouse; D051153:Wnt Proteins; D051176:beta Catenin
keywords: OLPs; Wnt; oligodendrocyte differentiation; spinal cord; β-catenin