title: Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy.
abstract: Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.
authors.affiliation: Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jtome@ua.pt.
authors.forename: Leandro M O
authors.initials: LM
authors.lastname: Lourenço
authors.forename: Patrícia M R
authors.initials: PM
authors.lastname: Pereira
authors.forename: Elisabete
authors.initials: E
authors.lastname: Maciel
authors.forename: Mónica
authors.initials: M
authors.lastname: Válega
authors.forename: Fernando M J
authors.initials: FM
authors.lastname: Domingues
authors.forename: Maria R M
authors.initials: MR
authors.lastname: Domingues
authors.forename: Maria G P M S
authors.initials: MG
authors.lastname: Neves
authors.forename: José A S
authors.initials: JA
authors.lastname: Cavaleiro
authors.forename: Rosa
authors.initials: R
authors.lastname: Fernandes
authors.forename: João P C
authors.initials: JP
authors.lastname: Tomé
mesh_terms: D002460:Cell Line; D002467:Cell Nucleus / Q000737:chemistry / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003505:Cyclodextrins / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D008027:Light; D008856:Microscopy, Fluorescence; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D003505:Cyclodextrins; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; C013647:phthalocyanine