title: Isocitrate dehydrogenase mutation is associated with tumor location and magnetic resonance imaging characteristics in astrocytic neoplasms.
abstract: The molecular subsets of glioma behave in biologically distinct ways. The present study detected isocitrate dehydrogenase(IDH) 1 andIDH2mutations in glioma to analyze whetherIDH-mutated gliomas are situated in certain preferential areas and to investigate their correlation with magnetic resonance imaging (MRI) characteristics. A series of 193 patients with astrocytic neoplasms (111 diffuse and 82 anaplastic astrocytomas), grouped according to prelabeled anatomical structures and the risk of surgery, were retrospectively reviewed forIDH1 andIDH2 mutations to compare the tumor location and MRI features. A total of 111IDH1 mutations at codon 132 (57.5%) and sixIDH2mutations at codon 172 (3.1%) were detected. TheIDH1/2mutations were found to predict longer survival, independent of the histological type in this series of patients. TheIDH-mutated gliomas were predominantly located in a single lobe, such as the frontal lobe, temporal lobe or cerebellum and rarely in the diencephalon or brain stem. Furthermore, according to the risk of surgery, theIDH-mutated tumors were rarely located in the high-risk regions of the brain, where surgery exhibits a high mortality rate intraoperatively and postoperatively. In addition, gliomas withIDHmutations were significantly more likely to exhibit a unilateral pattern of growth, sharp tumor margins, homogeneous signal intensity and less contrast enhancement on MRI. The results of the current study suggested that the prolonged survival of patients withIDH-mutated gliomas is primarily due to a less aggressive biological behavior according to tumor site and MRI features.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Hezhen
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Yanghui
authors.initials: Y
authors.lastname: Ou
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Huixia
authors.initials: H
authors.lastname: Han
authors.affiliation: Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Zhang
keywords: astrocytoma; isocitrate dehydrogenase; magnetic resonance imaging; prognosis; tumor location