title: Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis.
abstract: Multiple sclerosis (MS) is an autoimmune disease characterized by a triad of inflammation, demyelination and gliosis. Because the suppressors of cytokine signaling (Socs) regulate the immune response, we quantified SOCS1 and SOCS3 transcription in peripheral blood leukocytes of patients with MS. SOCS1 transcription decreased significantly in MS patients compared with neurologically healthy persons (0.08±0.02 vs. 1.02±0.23; p=0.0001); while SOCS3 transcription increased in MS patients compared with controls (2.76±0.66 vs. 1.03±0.27; p=0.0008). Our results showed an imbalance of SOCS1 and SOCS3 transcription in MS patients, and a moderated negative correlation between them (Spearman's r=-0.57; p=0.0003).
authors.affiliation: Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Puebla, México. Electronic address: virginia.sedeno@upaep.mx.
authors.forename: Virginia
authors.initials: V
authors.lastname: Sedeño-Monge
authors.affiliation: Servicio de Neurología, UMAE, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Puebla, México.
authors.forename: Raúl
authors.initials: R
authors.lastname: Arcega-Revilla
authors.affiliation: Universidad Politécnica de Puebla, Puebla, México.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Rojas-Morales
authors.affiliation: Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Santos-López
authors.affiliation: Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Perez-García
authors.affiliation: Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México.
authors.forename: Francisca
authors.initials: F
authors.lastname: Sosa-Jurado
authors.affiliation: Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México.
authors.forename: Verónica
authors.initials: V
authors.lastname: Vallejo-Ruiz
authors.affiliation: Current address: Department of Psychiatry, Idar-Oberstein GmbH Hospital, Rheinland-Palatinate, Germany.
authors.forename: Casandra Lucrecia
authors.initials: CL
authors.lastname: Solis-Morales
authors.affiliation: Departamento de Ciencias Biológicas, Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
authors.forename: Salvador
authors.initials: S
authors.lastname: Aguilar-Rosas
authors.affiliation: Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México.
authors.forename: Julio
authors.initials: J
authors.lastname: Reyes-Leyva
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D012189:Retrospective Studies; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: C108944:SOCS1 protein, human; C106644:SOCS3 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins
keywords: IFN-β; Multiple sclerosis; SOCS1; SOCS3