title: Prevalence of coeliac disease among adult patients with autoimmune hypothyroidism in Jordan.
abstract: The prevalence of coeliac disease among patients with autoimmune hypothyroidism has not been studied before in Jordan and other Arab countries. A cross-sectional record-based review was made of all adult autoimmune hypothyroidism patients who attended a referral centre in Jordan, during an 8-month period. Coeliac disease in these patients was diagnosed by the attending physician based on positive serological tests for anti-endomysial antibodies IgA and IgG followed by duodenal biopsy to confirm the diagnosis of coeliac disease. Of 914 patients recruited, 117 (12.8%) were seropositive for coeliac disease. Of 87 seropositive patients who underwent duodenal biopsy, 39 had positive histological findings of coeliac disease (44.8%). Extrapolating from these findings the overall rate of coeliac disease among autoimmune hypothyroidism patients was estimated to be 5.7%. In multivariate logistic regression coeliac disease was significantly associated with older age (> 40 years), presence of other autoimmune diseases, vitamin B12 deficiency and anaemia.
authors.affiliation: National Centre for Diabetes, Endocrinology and Genetics, Amman, Jordan.
authors.forename: O H
authors.initials: OH
authors.lastname: Farahid
authors.affiliation: National Centre for Diabetes, Endocrinology and Genetics, Amman, Jordan.
authors.forename: N
authors.initials: N
authors.lastname: Khawaja
authors.affiliation: Department of Gastroenterology and Liver Disease, Faculty of Medicine, University of Jordan, Amman, Jordan.
authors.forename: M M
authors.initials: MM
authors.lastname: Shennak
authors.affiliation: Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
authors.forename: A
authors.initials: A
authors.lastname: Batieha
authors.affiliation: National Centre for Diabetes, Endocrinology and Genetics, Amman, Jordan.
authors.forename: M
authors.initials: M
authors.lastname: El-Khateeb
authors.affiliation: National Centre for Diabetes, Endocrinology and Genetics, Amman, Jordan.
authors.forename: K
authors.initials: K
authors.lastname: Ajlouni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002446:Celiac Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000453:epidemiology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007597:Jordan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012044:Regression Analysis; D013967:Thyroiditis, Autoimmune
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G