title: Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy.
abstract: Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.
authors.affiliation: College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
authors.forename: Mina
authors.initials: M
authors.lastname: Elahy
authors.affiliation: College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
authors.forename: Swati
authors.initials: S
authors.lastname: Baindur-Hudson
authors.affiliation: College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, AustraliaCollege of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
authors.forename: Vinicius F
authors.initials: VF
authors.lastname: Cruzat
authors.affiliation: College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, AustraliaCollege of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
authors.forename: Philip
authors.initials: P
authors.lastname: Newsholme
authors.affiliation: College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, AustraliaCollege of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia Crispin.Dass@curtin.edu.au.
authors.forename: Crispin R
authors.initials: CR
authors.lastname: Dass
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis; D003929:Diabetic Neuropathies / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D042783:Endothelial Cells / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D008954:Models, Biological; D009249:NADP / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism; D018384:Oxidative Stress; D020286:Pericytes / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*; D015398:Signal Transduction; D051028:bcl-2-Associated X Protein / Q000378:metabolism; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D000975:Antioxidants; D005136:Eye Proteins; D009249:NADP; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D015843:Serpins; D051028:bcl-2-Associated X Protein; D000099174:Pigment Epithelium-Derived Factor; C494826:BAX protein, human
keywords: PEDF; diabetes; oxidative stress; pericyte; redox balance; signal transduction