title: Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma.
abstract: Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.
authors.affiliation: Department of Pediatric Hematology and Oncology, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel ; Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Elad
authors.initials: E
authors.lastname: Jacoby
authors.affiliation: Department of Pediatric Hematology and Oncology, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel ; Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Yalon
authors.affiliation: Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Leitner
authors.affiliation: Department of Neurosurgery, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Zvi R
authors.initials: ZR
authors.lastname: Cohen
authors.affiliation: Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Yehudit
authors.initials: Y
authors.lastname: Cohen
authors.affiliation: Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Tamar
authors.initials: T
authors.lastname: Fisher
authors.affiliation: Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Sarit
authors.initials: S
authors.lastname: Eder
authors.affiliation: Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Ninette
authors.initials: N
authors.lastname: Amariglio
authors.affiliation: Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Gideon
authors.initials: G
authors.lastname: Rechavi
authors.affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Simona
authors.initials: S
authors.lastname: Cazacu
authors.affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Cunli
authors.initials: C
authors.lastname: Xiang
authors.affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Mikkelsen
authors.affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA ; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Tel Aviv 52900, Israel.
authors.forename: Chaya
authors.initials: C
authors.lastname: Brodie
authors.affiliation: Department of Pediatric Hematology and Oncology, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel ; Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
authors.forename: Amos
authors.initials: A
authors.lastname: Toren
keywords: glioblastoma; glioma pathogenesis-related protein 1; methylation; related to testes-specific vespid and pathogenesis protein-1