title: Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.
abstract: A central hallmark of epigenetic inheritance is the parental transmission of changes in patterns of gene expression to progeny without modification of DNA sequence. Although, the trans-generational conveyance of this molecular memory has been traditionally linked to covalent modification of histone and/or DNA, recent studies suggest a role for proteins that persist or remain bound within chromatin to "bookmark" specific loci for enhanced or potentiated responses in daughter cells immediately following cell division. In this report we describe a role for p300 in enabling gene bookmarking by pre-initiation complexes (PICs) containing RNA polymerase II (pol II), Mediator and TBP. Once formed these complexes require p300 to enable reacquisition of protein complex assemblies, chromatin modifications and long range chromatin interactions that facilitate post-mitotic transmission of transcriptional memory of prior environmental stimuli.
authors.affiliation: Genetics Branch, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Madeline M
authors.initials: MM
authors.lastname: Wong
authors.affiliation: Genetics Branch, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Jung S
authors.initials: JS
authors.lastname: Byun
authors.affiliation: Genetics Branch, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Maria
authors.initials: M
authors.lastname: Sacta
authors.affiliation: Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America.
authors.forename: Qihuang
authors.initials: Q
authors.lastname: Jin
authors.affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: SongJoon
authors.initials: S
authors.lastname: Baek
authors.affiliation: Genetics Branch, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Kevin
authors.initials: K
authors.lastname: Gardner
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D050881:E1A-Associated p300 Protein / Q000172:deficiency / Q000235:genetics*; D044127:Epigenesis, Genetic; D055786:Gene Knockout Techniques; D045325:HCT116 Cells; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D040582:Inheritance Patterns; D019169:Jurkat Cells; D056892:Mediator Complex / Q000235:genetics / Q000378:metabolism; D008938:Mitosis; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D035181:TATA-Box Binding Protein / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D000097722:Cohesins; D000092468:Bromodomain Containing Proteins
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D050881:E1A-Associated p300 Protein; D006657:Histones; D056892:Mediator Complex; D009687:Nuclear Proteins; D012319:RNA Polymerase II; D035181:TATA-Box Binding Protein; D014157:Transcription Factors; D000097722:Cohesins; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C509817:TBP protein, human; C494360:EP300 protein, human