title: Lynx web services for annotations and systems analysis of multi-gene disorders.
abstract: Lynx is a web-based integrated systems biology platform that supports annotation and analysis of experimental data and generation of weighted hypotheses on molecular mechanisms contributing to human phenotypes and disorders of interest. Lynx has integrated multiple classes of biomedical data (genomic, proteomic, pathways, phenotypic, toxicogenomic, contextual and others) from various public databases as well as manually curated data from our group and collaborators (LynxKB). Lynx provides tools for gene list enrichment analysis using multiple functional annotations and network-based gene prioritization. Lynx provides access to the integrated database and the analytical tools via REST based Web Services (http://lynx.ci.uchicago.edu/webservices.html). This comprises data retrieval services for specific functional annotations, services to search across the complete LynxKB (powered by Lucene), and services to access the analytical tools built within the Lynx platform.
authors.affiliation: Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, IL 60637, USA sulakhe@mcs.anl.gov.
authors.forename: Dinanath
authors.initials: D
authors.lastname: Sulakhe
authors.affiliation: Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Taylor
authors.affiliation: Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Balasubramanian
authors.affiliation: Department of Computer Science, Illinois Institute of Technology, Chicago, IL 60616, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.affiliation: Department of Computer Science, Illinois Institute of Technology, Chicago, IL 60616, USA.
authors.forename: Bingqing
authors.initials: B
authors.lastname: Xie
authors.affiliation: Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA Toyota Technological Institute at Chicago, Chicago, IL 60637, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Börnigen
authors.affiliation: Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, IL 60637, USA.
authors.forename: Utpal J
authors.initials: UJ
authors.lastname: Dave
authors.affiliation: Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, IL 60637, USA.
authors.forename: Ian T
authors.initials: IT
authors.lastname: Foster
authors.affiliation: Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, IL 60637, USA Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
authors.forename: T Conrad
authors.initials: TC
authors.lastname: Gilliam
authors.affiliation: Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, IL 60637, USA Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Natalia
authors.initials: N
authors.lastname: Maltsev
mesh_terms: D016208:Databases, Factual; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D012984:Software; D049490:Systems Biology