title: A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes.
abstract: We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that is sensitive to redox changes within living cells.
authors.affiliation: School of Chemistry, The University of Sydney, New South Wales 2006, Australia. elizabeth.new@sydney.edu.au.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Yeow
authors.forename: Amandeep
authors.initials: A
authors.lastname: Kaur
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Anscomb
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: New
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D015374:Biosensing Techniques; D005415:Flavins / Q000737:chemistry*; D005453:Fluorescence; D005947:Glucose / Q000494:pharmacology*; D051379:Mice; D018613:Microscopy, Confocal; D015394:Molecular Structure; D053644:Naphthalimides / Q000737:chemistry*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D005415:Flavins; D053644:Naphthalimides; D005947:Glucose