title: [Thermolabile drugs: pharmacist intervention as a guarantee of cold chain maintenance].
abstract: OBJECTIVE
  To determine whether pharmacist is able to guarantee cold chain maintenance of thermolabile drugs during transport using the available information in the reception process and to compare these results with those obtained in a subsequent intervention phase, in which the manufacturing laboratories were contacted.
  
  
  METHODS
  Intervention study, prospective and comparative"before-after". It was analyzed the storage conditions during transport of all thermolabile drugs received in a 400-bed hospital for 3 months, excluding those from clinical trials.
  
  
  RESULTS
  The intervention allowed to ensure cold chain maintenance in 76,5% (n = 488) of received drugs, representing an increase of 41,8% (IC 95% 36,7-46,6%; p < 0,001) compared with the percentage obtained before the intervention.
  
  
  CONCLUSIONS
  The pharmacist isn't able to ensure the cold chain maintenance of received thermolabile drugs without temperature monitoring device (64,6%). Reports requested from laboratories allowed to increase significantly that percentage.
authors.affiliation: Residente de Farmacia Hospitalaria. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. España.. isabel_rlobera@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Ricote-Lobera
authors.affiliation: Residente de Farmacia Hospitalaria. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. España..
authors.forename: B
authors.initials: B
authors.lastname: Santos-Mena
authors.affiliation: FEA Farmacia. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. España..
authors.forename: S
authors.initials: S
authors.lastname: Fraile-Gil
authors.affiliation: Residente de Farmacia Hospitalaria. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. España..
authors.forename: B
authors.initials: B
authors.lastname: Ortiz-Martín
authors.affiliation: FEA Farmacia. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. España..
authors.forename: F J
authors.initials: FJ
authors.lastname: Hidalgo-Correas
authors.affiliation: Jefe de Servicio. Servicio de Farmacia. Hospital Universitario Severo Ochoa. Leganés. Madrid. España..
authors.forename: B
authors.initials: B
authors.lastname: García-Díaz
mesh_terms: D003080:Cold Temperature; D004355:Drug Stability; D008510:Medication Systems, Hospital / Q000458:organization & administration*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010595:Pharmacists; D010607:Pharmacy Service, Hospital / Q000458:organization & administration*; D011446:Prospective Studies; D012034:Refrigeration
chemical_list: D004364:Pharmaceutical Preparations