title: No association between genetic markers in BDNF gene and lithium prophylaxis in a Greek sample.
abstract: Abstract Lithium efficacy is, at least partially, under genetic control. We investigated the association between markers in BDNF and lithium prophylactic efficacy. A set of 10 SNPs within BDNF were genotyped in a sample of 83 bipolar patients. Response to lithium was assessed by presence or absence of any illness phases during a period of 3 years of longitudinal observation. No significant association was detected between the genetic variants tested in BDNF and lithium prophylaxis. Despite the negative association, limitations including small sample size suggest that larger scale genetic associations studies of these genes and lithium prophylaxis are nonetheless indicated.
authors.affiliation: Institute of Psychiatry, University of Bologna, Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Drago
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Rebecca
authors.initials: R
authors.lastname: Smith
authors.forename: Patricia
authors.initials: P
authors.lastname: Huezo-Diaz
authors.forename: Petros
authors.initials: P
authors.lastname: Malitas
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Diana De
authors.initials: DD
authors.lastname: Ronchi
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Aitchison
keywords: BDNF; bipolar disorder; genes; lithium; prevention and control