title: Silver carboxylate metal-organic frameworks with highly antibacterial activity and biocompatibility.
abstract: Two novel Ag-based metal-organic frameworks (MOFs) [Ag2(O-IPA)(H2O)·(H3O)] (1) and [Ag5(PYDC)2(OH)] (2) were synthesized under the hydrothermal conditions using aromatic-carboxylic acids containing hydroxyl and pyridyl groups as ligands (HO-H2IPA=5-hydroxyisophthalic acid and H2PYDC=pyridine-3, 5-dicarboxylic acid). Single crystal X-ray diffraction indicated that two compounds exhibit three-dimensional frameworks constructed from different rod-shaped molecular building blocks. Both compounds favor slow release of Ag(+) ions leading to excellent and long-term antimicrobial activities towards Gram-negative bacteria, Escherichia coli (E. coli) and Gram-positive bacteria, Staphylococcus aureus (S. aureus). Their antibacterial potency was evaluated by using a minimal inhibition concentration (MIC) benchmark and an inhibition zone testing. High-resolution transmission electron microscope images indicate that the Ag-based MOFs could rupture the bacterial membrane resulting in cell death. Hematological study showed that these MOFs exhibit good biocompatibility in mice. In addition, good thermal stability and optical stability under UV-visible and visible light are beneficial for their antibacterial application.
authors.affiliation: State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116012, PR China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116012, PR China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department Gastroenterology, The Second Hospital of Lanzhou University, Lanzhou University, PR China. Electronic address: sczdk1972@163.com.
authors.forename: Dekui
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department Gastroenterology, The Second Hospital of Lanzhou University, Lanzhou University, PR China.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116012, PR China.
authors.forename: Raji Feyisa
authors.initials: RF
authors.lastname: Bogale
authors.affiliation: State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116012, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116012, PR China.
authors.forename: Limei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Division of Mechanical Engineering, University of Dundee, UK.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116012, PR China. Electronic address: ninggl@dlut.edu.cn.
authors.forename: Guiling
authors.initials: G
authors.lastname: Ning
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D009942:Organometallic Compounds; D012834:Silver
keywords: Ag(+) release; Antibacterial activity; Biocompatibility; Metal–organic frameworks; Silver