title: Preconditioning with hyperbaric oxygen in pancreaticoduodenectomy: a randomized double-blind pilot study.
abstract: In a prospective randomized double-blind study, we evaluated the post-operative biological and clinical effects of a single preoperative hyperbaric-treatment the day before surgery for pancreatic ductal adenocarcinoma.
  
  
  METHODS
  Twenty one patients were randomized and divided into two groups: group-A (10 patients, 48%) were exposed to a HyperBaric Oxygen (HBO) session the day before intervention [Pre-Intervention Day (PID)], group-B (11 patients, 52%) breathed air for 40 min in a hyperbaric chamber pressurized to 1.15 ATA (placebo group). For all patients blood samples were obtained before HBO treatment or the placebo procedure (T0); at the end of HBO session or placebo procedure (T1); on the first post-operative day (POD)(T2) and on seventh POD(T3) day, measuring interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12 and TNF-α, recording postoperative pancreatic fistula (POPF), biliary-fistula, fever, intra-abdominal abscess, bleeding, pulmonary complications, delayed gastric emptying and requirement for post-operative antibiotics. The results of the present pilot study suggest that a single preoperative hyperbaric oxygen treatment on the day before surgery may reduce the complication rate in pancreatic resection.
authors.affiliation: Physiology Laboratory, Department of Biomedical Sciences, University of Padova, Padova, Italy ATIP Hyperbaric Medical Center, Padova, Italy vincenzo.zanon@gmail.com gerardo.bosco@unipd.it.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Bosco
authors.affiliation: Laboratory of Translational Surgery, University Laboratory for Medical Research, University of Verona, Verona, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Casarotto
authors.affiliation: Hyperbaric Medical Center Villafranca, Verona, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nasole
authors.affiliation: Anesthesiology FGTBA, Tampa General Hospital, Tampa, FL, U.S.A.
authors.forename: Enrico
authors.initials: E
authors.lastname: Camporesi
authors.affiliation: Laboratory of Translational Surgery, University Laboratory for Medical Research, University of Verona, Verona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvia
authors.affiliation: Laboratory of Translational Surgery, University Laboratory for Medical Research, University of Verona, Verona, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Giovinazzo
authors.affiliation: Laboratory of Translational Surgery, University Laboratory for Medical Research, University of Verona, Verona, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Zanini
authors.affiliation: Laboratory of Translational Surgery, University Laboratory for Medical Research, University of Verona, Verona, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Malleo
authors.affiliation: Physiology Laboratory, Department of Biomedical Sciences, University of Padova, Padova, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Tano
authors.affiliation: Physiology Laboratory, Department of Biomedical Sciences, University of Padova, Padova, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rubini
authors.affiliation: Physiology Laboratory, Department of Biomedical Sciences, University of Padova, Padova, Italy vincenzo.zanon@gmail.com gerardo.bosco@unipd.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Zanon
authors.affiliation: Anesthesiology FGTBA, Tampa General Hospital, Tampa, FL, U.S.A.
authors.forename: Devanand
authors.initials: D
authors.lastname: Mangar
authors.affiliation: Laboratory of Translational Surgery, University Laboratory for Medical Research, University of Verona, Verona, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D016207:Cytokines / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006931:Hyperbaric Oxygenation; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D010865:Pilot Projects; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: HBO; Pancreaticoduodenectomy; hyperbaric; pre-conditioning; surgery