title: Breast cancer recurrence after nipple-sparing mastectomy: one institution's experience.
abstract: BACKGROUND
  Nipple-sparing mastectomy (NSM) has been increasingly used to treat women with breast cancer who wish to preserve the overlying breast skin, but concern remains regarding tumor recurrence. We report our experience performing NSM for breast cancer treatment and prophylaxis over a 6-year period.
  
  
  METHODS
  A retrospective chart review on patients undergoing NSM or skin-sparing mastectomy (SSM) from 2005 to 2011 was performed.
  
  
  RESULTS
  NSM patients were younger (P < .001), had a lower body mass index (P < .001), and were associated with a family cancer risk (P = .01) but not genetic risk (P = .83). There was no difference in the distance between the tumor and the nipple-areola complex when comparing NSM and SSM (P = .47). There was no significant difference in recurrence (P = .08) or survival (P = .38) when comparing NSM and SSM after controlling for age, stage, and surgery laterality.
  
  
  CONCLUSIONS
  There was no difference in survival or cancer recurrence for NSM or SSM. NSM does not increase the risk of recurrence or decrease survival.
authors.affiliation: Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Poruk
authors.affiliation: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Ying
authors.affiliation: Department of Plastic and Reconstructive Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA.
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Chidester
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, 30 North 1900 East 3B 400, Salt Lake City, UT 84132, USA.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Olson
authors.affiliation: Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Cindy B
authors.initials: CB
authors.lastname: Matsen
authors.affiliation: Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Leigh
authors.initials: L
authors.lastname: Neumayer
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, 30 North 1900 East 3B 400, Salt Lake City, UT 84132, USA. Electronic address: Jay.Agarwal@hsc.utah.edu.
authors.forename: Jayant
authors.initials: J
authors.lastname: Agarwal
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015414:Mastectomy, Subcutaneous; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000401:mortality; D011183:Postoperative Complications / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Breast cancer; Cancer recurrence; NSM; Nipple-areola complex; Nipple-sparing mastectomy