title: Synthesis, crystal structure, DFT studies and evaluation of the antioxidant activity of 3,4-dimethoxybenzenamine schiff bases.
abstract: Schiff bases of 3,4-dimethoxybenzenamine 1-25 were synthesized and evaluated for their antioxidant activity. All the synthesized compounds were characterized by various spectroscopic techniques. In addition, the characterizations of compounds 13, 15 and 16 were supported by crystal X-ray determinations and their geometrical parameters were compared with theoretical DFT calculations at the B3LYP level of theory. Furthermore, the X-ray crystal data of two non-crystalline compounds 8 and 18 were theoretically calculated and compared with the practical values of compounds 13, 15, 16 and found a good agreement. The compounds showed good DPPH scavenging activity ranging from 10.12 to 84.34 μM where compounds 1-4 and 6 showed stronger activity than the standard n-propyl gallate. For the superoxide anion radical assay, compounds 1-3 showed better activity than the standard.
authors.affiliation: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, 42300 Puncak Alam Campus, Malaysia. nazif_umt@yahoo.com.
authors.forename: Ahmad Nazif
authors.initials: AN
authors.lastname: Aziz
authors.affiliation: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, 42300 Puncak Alam Campus, Malaysia. taha_hej@yahoo.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.affiliation: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, 42300 Puncak Alam Campus, Malaysia. noriz118@salam.uitm.edu.my.
authors.forename: Nor Hadiani
authors.initials: NH
authors.lastname: Ismail
authors.affiliation: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, 42300 Puncak Alam Campus, Malaysia. anouarelhassane@yahoo.fr.
authors.forename: El Hassane
authors.initials: el H
authors.lastname: Anouar
authors.affiliation: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270 Karachi, Pakistan. dr.sammer.yousuf@gmail.com.
authors.forename: Sammer
authors.initials: S
authors.lastname: Yousuf
authors.affiliation: Institute of Advance Research Studies in Chemical Sciences, University of Sindh Jamshoro, Hyderabad 76080, Pakistan. waqas143kh@yahoo.com.
authors.forename: Waqas
authors.initials: W
authors.lastname: Jamil
authors.affiliation: Department of Chemistry, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my.
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.affiliation: Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia. noriz118@salam.uitm.edu.my.
authors.forename: Norizan
authors.initials: N
authors.lastname: Ahmat
authors.affiliation: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270 Karachi, Pakistan. khalid.khan@iccs.edu.
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.affiliation: Institute of Advance Research Studies in Chemical Sciences, University of Sindh Jamshoro, Hyderabad 76080, Pakistan. hope_cancer@yahoo.com.
authors.forename: Syed Muhammad
authors.initials: SM
authors.lastname: Kashif
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D016166:Free Radical Scavengers / Q000737:chemistry; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D012545:Schiff Bases; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl