title: Primary testicular lymphoma with subcutaneous masses as the sole manifestation of the first relapse and central nervous system lymphoma as the second relapse: A case report and literature review.
abstract: Primary testicular lymphoma (PTL) accounts for ~1% of all non-Hodgkin's lymphomas and has a marked tendency for systemic relapse. The current study presents a unique case of testicular diffuse large B-cell lymphoma of non-germinal center B-cell subtype, with subcutaneous masses as the sole manifestation of the first relapse and central nervous system lymphoma as the second relapse. Subcutaneous relapse and subsequent brain relapse are extremely rare signs of PTL dissemination. The patient received methotrexate-based combined chemotherapy and achieved a partial response. This case presents a rare pattern of treatment failure in this malignant clinical entity.
authors.affiliation: Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Zunguo
authors.initials: Z
authors.lastname: DU
authors.affiliation: Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Leng
authors.affiliation: Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tang
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Zi
authors.initials: Z
authors.lastname: Chen
keywords: primary testicular lymphoma; relapse; subcutaneous soft tissue