title: Renin release: role of SNAREs.
abstract: Little is known about the molecular mechanism mediating renin granule exocytosis and the identity of proteins involved. We previously showed that soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNAREs), a family of proteins required for exocytosis, mediate the stimulated release of renin from juxtaglomerular cells. This minireview focuses on the current knowledge of the proteins that facilitate renin-granule exocytosis. We discuss the identity of potential candidates that mediate the signaling and final steps of exocytosis of the renin granule.
authors.affiliation: Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan mmendez1@hfhs.org.
authors.forename: Mariela
authors.initials: M
authors.lastname: Mendez
mesh_terms: D000818:Animals; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000378:metabolism; D008561:Membrane Fusion / Q000502:physiology; D012083:Renin / Q000378:metabolism*; D050600:SNARE Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D050600:SNARE Proteins; D012083:Renin
keywords: SNAREs; cAMP; exocytosis; hypertension; renin