title: Rapid and ultrasensitive electrochemical detection of multidrug-resistant bacteria based on nanostructured gold coated ITO electrode.
abstract: Rapid and ultrasensitive detection of pathogenic bacteria and their relevant multidrug resistance is particularly important in clinical diagnosis, disease control, and environmental monitoring. In this contribution, we have explored the possibility to rapidly detect some important disease related bacteria based on a nanostructured Au modified indium tin oxide electrode through the antibiotic agents such as doxorubicin. The rapid and real-time electrochemical detection of multidrug resistant bacteria like Escherichia coli and Staphylococcus aureus could be readily realized through the nanostructured Au based biosensor with high sensitivity. The observations of surface-enhanced Raman spectroscopy and laser confocal fluorescence microscopy also demonstrate the effectiveness of the relevant new strategy for the rapid and ultrasensitive electrochemical detection of some disease related bacteria.
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Department of Biological Science and Medical Engineering, Southeast University , Nanjing 210096, China.
authors.forename: Xiayi
authors.initials: X
authors.lastname: Lv
authors.forename: Wei
authors.initials: W
authors.lastname: Ge
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Li
authors.forename: Yueli
authors.initials: Y
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D024901:Drug Resistance, Multiple, Bacterial; D004566:Electrodes; D004926:Escherichia coli; D006046:Gold / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D012680:Sensitivity and Specificity; D013211:Staphylococcus aureus
chemical_list: D007204:Indium; C047711:indium oxide; D006046:Gold