title: Perceived barriers to the implementation of Isoniazid preventive therapy for people living with HIV in resource constrained settings: a qualitative study.
abstract: BACKGROUND
  Isoniazid preventive therapy (IPT) reduces the risk of active TB. IPT is a key public health intervention for the prevention of TB among people living with HIV and has been recommended as part of a comprehensive HIV and AIDS care strategy. However, its implementation has been very slow and has been impeded by several barriers.
  
  
  OBJECTIVE
  The Objective of the study is to assess the perceived barriers to the implementation of Isoniazid preventive therapy for people living with HIV in resource constrained settings in Addis Ababa, Ethiopia in 2010.
  
  
  METHODS
  A qualitative study using a semi-structured interviewed guide was used for the in-depth interview. A total of 12 key informants including ART Nurse, counselors and coordinators found in four hospitals were included in the interview. Each session of the in-depth interview was recorded via audio tape and detailed notes. The interview was transcribed verbatim. The data was analyzed manually.
  
  
  RESULTS
  The findings revealed that poor patient adherence was a major factor; with the following issues cited as the reasons for poor adherence; forgetfulness; lack of understanding of condition and patient non- disclosure of HIV sero-status leading to insubstantial social support; underlying mental health issues resulting in missed or irregular patient appointments; weak patient/healthcare provider relationship due to limited quality interaction; lack of patient information, patient empowerment and proper counseling on IPT; and the deficient reinforcement by health officials and other stakeholders on the significance of IPT medication adherence as a critical for positive health outcomes.
  
  
  CONCLUSIONS
  Uptake of the implementation of IPT is facing a challenge in resource limited settings. This recalled provision of training/capacity building and awareness creation mechanism for the health workers, facilitating disclosure and social support for the patients is recommended.
authors.affiliation: Department of General Public Health, College of Public Health and Medical Science, Jimma University, Ethiopia.
authors.forename: Mesele
authors.initials: M
authors.lastname: Mindachew
authors.affiliation: Department of Epidemiology, College of Public Health and Medical Science, Jimma University, Jimma, Ethiopia.
authors.forename: Amare
authors.initials: A
authors.lastname: Deribew
authors.affiliation: University of Maryland School of Medicine-Institute of Human Virology, Baltimore, MD.
authors.forename: Peter
authors.initials: P
authors.lastname: Memiah
authors.affiliation: Department of Epidemiology, College of Public Health and Medical Science, Jimma University, Jimma, Ethiopia.
authors.forename: Sibhatu
authors.initials: S
authors.lastname: Biadgilign
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000191:economics / Q000523:psychology; D003144:Communication Barriers; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D015497:HIV-1; D006284:Health Plan Implementation / Q000191:economics; D006295:Health Resources / Q000191:economics; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010465:Perception; D011204:Poverty Areas
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid
keywords: Isoniazid preventive therapy; People Living with HIV; TB