title: Remote-controlled drug release from graphene oxide-capped mesoporous silica to cancer cells by photoinduced pH-jump activation.
abstract: Remote light control of drug release enhances our ability to address the complexity of biological systems because of its remarkable spatial/temporal resolution. Here, a new class of remote-controlled release system by incorporating photoacid generator (PAG) into graphene oxide-capped mesoporous silica was designed for delivering drug payloads to cancer cells via photoinduced pH-jump activation. PAG was immobilized on pore wall of the boronic acid-grafted mesoporous silica via strong physical adsorption, and then the nanoparticle was capped with graphene oxide sheet by an acid-labile boroester bond, leading to the formation of nanogated ensemble (MSP-BA-GO). Illuminating with a UV light, PAG generated a pH jump, which induced cleavage of the boroester linkers and thus resulted in the uncapping of pore gates. Moreover, folic acid-modified, doxorubicin (DOX)-loaded MSP-BA-GO (DOX@MSP-BA-GOF) showed selective cell internalization via receptor-mediated endocytosis and subsequent released DOX by the remote illumination. We envisioned that this remote-controlled drug delivery system could find potential applications for cancer therapy.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University , Changsha 410082, P. R. China.
authors.forename: Dinggeng
authors.initials: D
authors.lastname: He
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: He
authors.forename: Kemin
authors.initials: K
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zou
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Xuecai
authors.initials: X
authors.lastname: Li
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D005434:Flow Cytometry; D005492:Folic Acid / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D003692:Delayed-Action Preparations; D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin; D005492:Folic Acid