title: Correlation analysis of EV71 detection and case severity in hand, foot, and mouth disease in the Hunan Province of China.
abstract: An increase in the incidence of hand, foot and mouth disease (HFMD) cases has been observed in the Hunan province of mainland China since 2009 with a particularly higher level of severe cases in 2010-2012. Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71) and Coxsackievirus A16 (Cox A16) being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively). For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression.
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Gao
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Shi-Xiong
authors.initials: SX
authors.lastname: Hu
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Kai-Wei
authors.initials: KW
authors.lastname: Luo
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Yun-Zhi
authors.initials: YZ
authors.lastname: Liu
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Qiao-Hua
authors.initials: QH
authors.lastname: Xu
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Deng
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Shuai-Feng
authors.initials: SF
authors.lastname: Zhou
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Liu
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Hunan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000821:virology; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000821:virology; D006801:Humans; D015994:Incidence; D012720:Severity of Illness Index; D016019:Survival Analysis