title: Determinants of brachial-ankle pulse wave velocity and carotid-femoral pulse wave velocity in healthy Koreans.
abstract: The aim of this study was to determine the normal value of brachial-ankle pulse wave velocity (baPWV) and carotid-femoral pulse wave velocity (cfPWV) according to age group, gender, and the presence of cardiovascular risk factors in healthy Koreans, and to investigate the association between PWV and risk factors such as prehypertension, dyslipidemia, smoking, and obesity. We measured an arterial stiffness in 110 normal subjects who were 20 to 69 yr-old with no evidence of cardiovascular disease, cerebrovascular accident or diabetes mellitus. The mean values of baPWV and cfPWV were 12.6 (± 2.27) m/sec (13.1 ± 1.85 in men, 12.1 ± 2.51 in women; P=0.019) and 8.70 (± 1.99) m/sec (9.34 ± 2.13 in men, 8.15 ± 1.69 in women; P=0.001), respectively. The distribution of baPWV (P<0.001) and cfPWV (P=0.006) by age group and gender showed an increase in the mean value with age. Men had higher baPWV and cfPWV than women (P<0.001). There was a difference in baPWV and cfPWV by age group on prehypertension, dyslipidemia, current smoking, or obesity (P<0.001). In multiple linear regression, age and prehypertension were highly associated with baPWV and cfPWV after adjustment for confounding factors (P<0.001). The present study showed that baPWV and cfPWV are associated with age, gender, and prehypertension in healthy Koreans.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Vascular Center, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Shin Yi
authors.identifier: 0000-0003-4319-7029
authors.initials: SY
authors.lastname: Jang
authors.affiliation: Graduate School of Public Health, Seoul National University, Seoul, Korea.
authors.forename: Eun Young
authors.identifier: 0000-0003-4263-9120
authors.initials: EY
authors.lastname: Ju
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Vascular Center, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Eun Hee
authors.identifier: 0000-0002-1180-6566
authors.initials: EH
authors.lastname: Huh
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Vascular Center, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jung Hyun
authors.identifier: 0000-0002-2965-0942
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Vascular Center, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Duk-Kyung
authors.identifier: 0000-0001-9227-4196
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D055109:Ankle Brachial Index; D001794:Blood Pressure; D001916:Brachial Artery / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002339:Carotid Arteries / Q000502:physiology*; D005260:Female; D005263:Femoral Artery / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D058246:Prehypertension / Q000503:physiopathology; D011673:Pulsatile Flow; D063177:Pulse Wave Analysis; D056910:Republic of Korea; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D059289:Vascular Stiffness / Q000502:physiology
keywords: Age Groups; Ankle Brachial Index; Carotid-Femoral; Gender Identity; Prehypertension; Pulse Wave Analysis