title: The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme.
abstract: The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.
authors.affiliation: Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Messori
authors.forename: Tiziano
authors.initials: T
authors.lastname: Marzo
authors.forename: Antonello
authors.initials: A
authors.lastname: Merlino
mesh_terms: D001665:Binding Sites; D016190:Carboplatin / Q000737:chemistry / Q000378:metabolism; D002945:Cisplatin / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D009113:Muramidase / Q000737:chemistry* / Q000378:metabolism; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism; D000077150:Oxaliplatin; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D016190:Carboplatin; C421864:hen egg lysozyme; D009113:Muramidase; D002945:Cisplatin