title: UCbase 2.0: ultraconserved sequences database (2014 update).
abstract: UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it.
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Lomonaco
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Martoglia
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Mandreoli
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Anderlucci
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy.
authors.forename: Warren
authors.initials: W
authors.lastname: Emmett
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Bicciato
authors.affiliation: Computer Engineering Department, University of Modena, Via Campi 213/b, 44100, Modena, Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, 40126, Bologna, Italy, Department of Genetics, Environment and Evolution, Genetics Institute, University College London, London, WC1E 6BT, UK and Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy cristian.taccioli@unimore.it taccioli@gmail.com.
authors.forename: Cristian
authors.initials: C
authors.lastname: Taccioli
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D030541:Databases, Genetic; D006801:Humans; D051379:Mice; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051381:Rats; D057386:Search Engine; D012984:Software; D014584:User-Computer Interface