title: Association of CDC25 phosphatase family polymorphisms with the efficacy/toxicity of platinum-based chemotherapy in Chinese advanced NSCLC patients.
abstract: OBJECTIVE
  To explore relationships between single nucleotide polymorphisms (SNPs) of the CDC25 protein family and the survival and chemotherapy responses of patients with advanced non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  We genotyped 14 SNPs of the CDC25 family in 663 Chinese patients with advanced NSCLC who were treated with first-line platinum-based chemotherapy and, in evaluable patients, analyzed relationships between the CDC25 family and the efficacy of platinum-based chemotherapy.
  
  
  RESULTS
  CDC25A rs3731513 and rs1380053, CDC25C rs6861656, CDC25A haplotype T/A/A/A/C and CDC25C haplotype A/G/G/G/C were significantly associated with the patients' progression-free survival. In addition, CDC25B rs3761218 and haplotype G/T/G/G were associated with the occurrence of severe toxicity with platinum-based chemotherapy, especially gastrointestinal and hematological toxicity.
  
  
  CONCLUSIONS
  These findings reveal a relationship between genetic variations of the CDC25 family and the efficacy and toxicity of platinum-based chemotherapy in patients with advanced NSCLC, especially in those with non-squamous-cell carcinoma.
authors.affiliation: Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507, Zheng Min Road, Shanghai, 200433, P.R. China.
authors.forename: Weijing
authors.initials: W
authors.lastname: Cai
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.forename: Xinzheng
authors.initials: X
authors.lastname: Li
authors.forename: Jinyun
authors.initials: J
authors.lastname: Shi
authors.forename: Qian
authors.initials: Q
authors.lastname: Sun
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Sun
authors.forename: Likun
authors.initials: L
authors.lastname: Hou
authors.forename: Xueying
authors.initials: X
authors.lastname: Zhao
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gu
authors.forename: Qihan
authors.initials: Q
authors.lastname: Wu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: Ke
authors.initials: K
authors.lastname: Fei
authors.forename: Bo
authors.initials: B
authors.lastname: Su
authors.forename: Ji
authors.initials: J
authors.lastname: Qian
mesh_terms: D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D020687:cdc25 Phosphatases / Q000235:genetics*
chemical_list: D009944:Organoplatinum Compounds; D020687:cdc25 Phosphatases
keywords: CDC25 family; chemotherapy; lung cancer; platinum; single nucleotide polymorphism