title: Single-nucleotide polymorphisms of LIG1 associated with risk of lung cancer.
abstract: To investigate the association of LIG1 with the risk of lung cancer, all subjects of unrelated ethnic Han Chinese in Liaoning Province were involved in a hospital-based case-control study. The case group consisted of 370 histologically diagnosed lung cancer patients; 314 controls were selected from cancer-free patients during Dec. 2009 to Dec. 2011. LIG1 rs1050298SNP were analyzed by TaqMan real-time PCR method. All statistical analyses were performed with Statistical Product and Service Solution sv13.0 (SPSS). The genotype distribution frequency of LIG1 rs1050298 SNP displayed significant difference between the case and the control group. Individuals carrying the LIG1 rs1050298 T genotype had higher risks of lung cancer, especially those with squamous cell carcinoma.
authors.affiliation: Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Chongshan East Street No. 4, Yuhong District, Shenyang, 110032, People's Republic of China.
authors.forename: Yan-Zhi
authors.initials: YZ
authors.lastname: Chen
authors.forename: Zeng-Hui
authors.initials: ZH
authors.lastname: Fan
authors.forename: Yu-Xia
authors.initials: YX
authors.lastname: Zhao
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
authors.forename: Bao-Shen
authors.initials: BS
authors.lastname: Zhou
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C000607892:LIG1 protein, human; D011088:DNA Ligases; D000072481:DNA Ligase ATP