title: The Effect of Lactic Acid Bacteria-fermented Soybean Milk Products on Carrageenan-induced Tail Thrombosis in Rats.
abstract: Thrombosis is characterized by congenital and acquired procatarxis. Lactic acid bacteria-fermented soybean milk products (FS-LAB) inhibit hepatic lipid accumulation and prevent atherosclerotic plaque formation. However, the therapeutic efficacy of FS-LAB against thrombosis has yet to be investigated. In this study, FS-LAB were administered subcutaneously into the tails of rats, with the subsequent intravenous administration of κ-carrageenan 12 hr after the initial injection. In general, administration of κ-carrageenan induces thrombosis. The length of the infarcted tail regions was significantly shorter in the rats administered a single-fold or double-fold concentration of the FS-LAB solution compared with the region in control rats. Therefore, FS-LAB exhibited significant antithrombotic effects. Our study is the first to characterize the properties of FS-LAB and, by testing their efficacy on an in vivo rat model of thrombosis, demonstrate the potency of their antithrombotic effect.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis ten bosch, Sasebo 859-3298, Japan.
authors.forename: Seitaro
authors.initials: S
authors.lastname: Kamiya
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis ten bosch, Sasebo 859-3298, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ogasawara
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis ten bosch, Sasebo 859-3298, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Arakawa
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis ten bosch, Sasebo 859-3298, Japan.
authors.forename: Masayori
authors.initials: M
authors.lastname: Hagimori
keywords: fermented soybean milk products; lactic acid bacteria; rat tail; thrombosis; κ-carrageenan