title: Analysis of TFRNs associated with steroid hormone-related cancers.
abstract: Estrogen and androgen are important endocrine hormones that control physiological functions in reproductive organs and play roles in the generation and/or progression of steroid hormone-related cancers. Their cognate receptors function as hormone-dependent transcription factors, which directly regulate the expression of their target genes. Genome-wide analysis of hormone receptor-related networks will provide new insights into the understanding of the molecular mechanism orchestrated by estrogen and androgen receptors, and will enable the development of new methods for the diagnosis and treatment of steroid hormone-related cancers.
authors.affiliation: Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ikeda
authors.forename: Kuniko
authors.initials: K
authors.lastname: Horie-Inoue
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
mesh_terms: D001940:Breast / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D018929:Cell Culture Techniques / Q000379:methods; D002465:Cell Movement; D049109:Cell Proliferation; D047369:Chromatin Immunoprecipitation / Q000379:methods; D018076:DNA, Complementary / Q000235:genetics; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D061986:MCF-7 Cells; D011401:Promoter Regions, Genetic; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D018076:DNA, Complementary; D004967:Estrogens; D011960:Receptors, Estrogen; D014157:Transcription Factors