title: Diarylheptanoids from green alder bark and their potential for DNA protection.
abstract: Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 16, RS-11000 Belgrade (phone: +381-11-2630474; fax: +381-11-2636061). mironov76@yahoo.com.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Novaković
authors.forename: Miroslava
authors.initials: M
authors.lastname: Stanković
authors.forename: Ivan
authors.initials: I
authors.lastname: Vučković
authors.forename: Nina
authors.initials: N
authors.lastname: Todorović
authors.forename: Snežana
authors.initials: S
authors.lastname: Trifunović
authors.forename: Danijela
authors.initials: D
authors.lastname: Apostolović
authors.forename: Boris
authors.initials: B
authors.lastname: Mandić
authors.forename: Milan
authors.initials: M
authors.lastname: Veljić
authors.forename: Petar
authors.initials: P
authors.lastname: Marin
authors.forename: Vele
authors.initials: V
authors.lastname: Tešević
authors.forename: Vlatka
authors.initials: V
authors.lastname: Vajs
authors.forename: Slobodan
authors.initials: S
authors.lastname: Milosavljević
mesh_terms: D029661:Alnus / Q000737:chemistry*; D002869:Chromosome Aberrations / Q000187:drug effects*; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D015162:Micronucleus Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D036381:Diarylheptanoids; D004247:DNA
keywords: Cytokinesis-block micronucleus (CBMN) assay; Green alder; Heptanoids, diaryl-