title: CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations.
abstract: It is reported that CLU rs2279590 polymorphism is significantly associated with Alzheimer's disease (AD) in European ancestry. Recent studies investigated rs2279590 polymorphism in Asian population (Chinese, Japanese and Korean). Four studies showed negative association and two studies showed weak association between rs2279590 and AD. We believe that the weak association or no association may be caused by the relatively small sample size in Asian population. Here, we reinvestigated the association in Asian population. Meanwhile, to investigate the genetic heterogeneity of the rs2279590 polymorphism in Asian and Caucasian populations, we searched the PubMed and AlzGene databases and selected 11 independent studies (6 studies in Asian population and 5 studies in Caucasian population) including 20,655 individuals (8,605 cases and 12,050 controls) for meta-analysis. Our results showed significant association between rs2279590 polymorphism and AD in Asian population with P = 2.00E-04 and P = 2.00E-04 using additive and recessive models, respectively. We observed no significant heterogeneity between Asian and Caucasian populations. We believe that our results may be helpful to understand the mechanisms of CLU in AD pathogenesis and will be useful for future genetic studies in AD.
authors.affiliation: Department of Neurology, The Forth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Shuyan
authors.initials: S
authors.lastname: Zhang
authors.forename: Donghui
authors.initials: D
authors.lastname: Zhang
authors.forename: Yongshuai
authors.initials: Y
authors.lastname: Jiang
authors.forename: Lina
authors.initials: L
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Liu
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
authors.forename: Liangcai
authors.initials: L
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D051152:Clusterin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D039781:PubMed / Q000706:statistics & numerical data; D012680:Sensitivity and Specificity; D044465:White People
chemical_list: C495242:CLU protein, human; D051152:Clusterin