title: Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis.
abstract: Influenza vaccination is recommended in cystic fibrosis patients. The objective of this study was to assess the immunogenicity of vaccination against 2009 pandemic A/H1N1 influenza and to study the factors associated with the immune response in patients with cystic fibrosis. 122 patients with cystic fibrosis were enrolled in a prospective study and received 1 dose of 2009/H1N1v adjuvanted vaccine, or for children <2 years and lung-transplanted patients, two doses of non-adjuvanted 2009/H1N1v vaccine administered 21 days apart. Hemagglutination inhibition antibodies were assessed before and 21 days after vaccination and at least 6 months after vaccination. After vaccination, 85% of the patients had an influenza antibody titer ≥1:40 and 69% seroconverted. 13% of the transplanted patients seroconverted compared with 72% of the non-transplanted patients. In this latter group, non-adjuvanted vaccine and low body mass index were independently associated with lower response to vaccination. 86% of the non-transplanted patients with normal BMI and receiving adjuvanted vaccine seroconverted. Persistence of seroprotection 10 months after vaccination was found in 50% of the patients. In patients with cystic fibrosis, malnutrition and receipt of non-adjuvanted vaccine were associated with lower immune response to pandemic influenza vaccination. Our data also suggest a potential defect in the immune response to influenza vaccination of patients with cystic fibrosis and raise the question of whether a different immunization strategy is needed.
authors.affiliation: Inserm, CIC 1417, Paris, France; Université Paris Descartes, Paris Sorbonne Cité, Paris, France; Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, CIC Cochin-Pasteur, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Launay
authors.affiliation: INSERM, U707, Paris, France.
authors.forename: P Y
authors.initials: PY
authors.lastname: Boelle
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, Service de Virologie, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Krivine
authors.affiliation: Hôpital Foch, Service de Pneumologie, Suresnes, France.
authors.forename: D
authors.initials: D
authors.lastname: Grenet
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Chirurgie Thoracique, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Boussaud
authors.affiliation: Centre Hospitalier Intercommunal de Créteil, Centre de Ressources et de Compétences en Mucoviscidose, Créteil, France.
authors.forename: N
authors.initials: N
authors.lastname: Rémus
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Trousseau, Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Corvol
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie- Allergologie Pediatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Chedevergne
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, Service de Pneumologie, Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Hubert
authors.affiliation: Université Paris Descartes, Paris Sorbonne Cité, Paris, France; Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie- Allergologie Pediatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France; INSERM U 1151, Paris, France. Electronic address: isabelle.sermet@nck.aphp.fr.
authors.forename: I
authors.initials: I
authors.lastname: Sermet-Gaudelus
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines
keywords: Adjuvanted vaccine; Cystic fibrosis; Influenza; Malnutrition; Pandemic; Vaccine