title: Synchronous bladder and prostate cancers in the specimens of radical cystoprostatectomy: a multicenter retrospective analysis.
abstract: The purpose of this study was to evaluate the features of prostate cancer that have been incidentally detected in radical cystoprostatectomy specimens of bladder cancer patients. The researchers of the current study retrospectively evaluated the data from 119 men who underwent radical cystoprostatectomy at four referral institutions in Ankara, Turkey. Of the 21 prostate cancer patients, 17 (81%) were aged ≥ 60 years; 10 (47.6%) had clinically significant diseases; three had a Gleason score of 6, three had a Gleason score of 7, three had a Gleason score of 8, one had a positive surgical margin along with extracapsular invasion of the tumor and a high Gleason score, and three patients had a tumor volume of ≥ 0.5 cm(3), of which two also had a high Gleason score. Patients were followed-up for a mean of 29 ± 10.2 months; the overall survival was 96.6% (n = 115) during that period. Preoperative digital rectal examination and prostate-specific antigen values did not differ between the benign and prostate cancer groups. There was no survival advantage in the insignificant prostate cancer and benign prostate groups. No additional benefit for predicting prostate cancer was found with digital rectal examination and prostate-specific antigen tests, although some clinicians advised such. In patients aged < 60 years, organ-sparing cystectomy seems reasonable. In prostate-sparing surgery, candidates who are aged >60 years, the preoperative work-up may routinely include prostate biopsy, especially the apex. Preoperative findings of multifocality of bladder cancers and the presence of carcinoma in situ have the risk of prostatic involvement.
authors.affiliation: Department of Urology, Ankara Research And Training Hospital, Ankara, Turkey. Electronic address: bcemozgur@hotmail.com.
authors.forename: Berat Cem
authors.initials: BC
authors.lastname: Ozgür
authors.affiliation: Department of Urology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Köseoğlu
authors.affiliation: Department of Urology, Ankara Onkoloji Research and Training Hospital, Ankara, Turkey.
authors.forename: Ali İhsan
authors.initials: Aİ
authors.lastname: Arık
authors.affiliation: Department of Urology, Ankara Research And Training Hospital, Ankara, Turkey.
authors.forename: Haşmet
authors.initials: H
authors.lastname: Sarıcı
authors.affiliation: Department of Urology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors.forename: Ovünç
authors.initials: O
authors.lastname: Bilgin
authors.affiliation: Department of Urology, Ankara Research And Training Hospital, Ankara, Turkey.
authors.forename: Cem Nedim
authors.initials: CN
authors.lastname: Yücetürk
authors.affiliation: Department of Pathology, Ankara Research and Training Hospital, Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Ozer
authors.affiliation: Department of Urology, Ankara Onkoloji Research and Training Hospital, Ankara, Turkey.
authors.forename: Eşref Oğuz
authors.initials: EO
authors.lastname: Güven
authors.affiliation: Department of Urology, Ankara Research And Training Hospital, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Telli
authors.affiliation: Department of Urology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Atan
authors.affiliation: Department of Urology, Ankara Research And Training Hospital, Ankara, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Eroğlu
mesh_terms: D000368:Aged; D015653:Cystectomy; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000601:surgery*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000601:surgery*
keywords: Bladder cancer; Incidental prostate cancer; Radical cystoprostatectomy