title: Plant phytochemicals: potential anticancer agents against gastric cancer.
abstract: Isothiocyanates (ITCs) are plant phytochemicals derived from vegetables consumed by human. ITCs comprise potent anti-carcinogenic agents of which the consumption has been linked to a reduced risk of cancer at several locations in the body. However, the studies on coping with gastric cancer remain unsatisfied. In the present review, ITCs are discussed in this context as ITCs may target gastric tumorigenesis at multiple levels. ITCs are taken up in the stomach, exposing mucosal and muscle layer cells as well as affecting Helicobacter pylori residing in the stomach. The natural and potent anti-cancer ITCs from vegetables have a great potential against gastric cancer, a disease in need of new treatment or preventive modalities.
authors.affiliation: Department of Biology, Norwegian University of Science and Technology, Høgskoleringen 5, N-7491 Trondheim, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7034 Trondheim, Norway. Electronic address: anders.overby@bio.ntnu.no.
authors.forename: Anders
authors.initials: A
authors.lastname: Øverby
authors.affiliation: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7034 Trondheim, Norway.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Zhao
authors.affiliation: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7034 Trondheim, Norway.
authors.forename: Duan
authors.initials: D
authors.lastname: Chen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology / Q000627:therapeutic use*; D064209:Phytochemicals / Q000494:pharmacology / Q000627:therapeutic use*; D013270:Stomach / Q000382:microbiology; D013274:Stomach Neoplasms / Q000517:prevention & control*; D014675:Vegetables
chemical_list: D000900:Anti-Bacterial Agents; D016588:Anticarcinogenic Agents; D017879:Isothiocyanates; D064209:Phytochemicals; C037152:isothiocyanic acid