title: Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms.
abstract: Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA. Electronic address: gtang@mdanderson.org.
authors.forename: Guilin
authors.initials: G
authors.lastname: Tang
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Sa A
authors.initials: SA
authors.lastname: Wang
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Lu
authors.affiliation: Department of Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Hans Chulhee
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Department of Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Muzaffar H
authors.initials: MH
authors.lastname: Qazilbash
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Xiaohong I
authors.initials: XI
authors.lastname: Wang
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: C Cameron
authors.initials: CC
authors.lastname: Yin
authors.affiliation: Department of Lymphoma/Myeloma, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Orlowski
authors.affiliation: Department of Biostatistics, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Ankita
authors.initials: A
authors.lastname: Patel
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
authors.affiliation: Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000139:chemically induced*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced; D016609:Neoplasms, Second Primary / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents
keywords: Bone marrow; Clonal cytogenetic abnormalities; Cytotoxic therapy; Silent; Therapy-related myeloid neoplasms