title: A facility for magnetic resonance-guided radiation therapy.
abstract: Magnetic resonance (MR) imaging is routinely employed in the design of radiotherapy (RT) treatment plans for many disease sites. It is evident that tighter integration of MR imaging into the RT process would increase confidence in dose placement and facilitate the integration of new MR imaging information (including anatomical and functional imaging) into the therapy process. To this end, a dedicated MR-guided RT (MRgRT) facility has been created that integrates a state-of-the-art linear accelerator delivery system, high-dose rate brachytherapy afterloader, and superconducting MR scanner to allow MR-based online treatment guidance, adaptive replanning, and response monitoring while maintaining the clinical functionality of the existing delivery systems. This system is housed within a dedicated MRgRT suite and operates in a coordinated fashion to assure safe and efficient MRgRT treatments.
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada. Electronic address: David.Jaffray@rmp.uhn.on.ca.
authors.forename: David A
authors.initials: DA
authors.lastname: Jaffray
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Marco C
authors.initials: MC
authors.lastname: Carlone
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Milosevic
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Breen
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada.
authors.forename: Teodor
authors.initials: T
authors.lastname: Stanescu
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rink
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Hamideh
authors.initials: H
authors.lastname: Alasti
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Anna
authors.initials: A
authors.lastname: Simeonov
authors.affiliation: Varian Medical Systems, Palo Alto, CA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Sweitzer
authors.affiliation: IMRIS, Minneapolis, MN.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Winter
mesh_terms: D005160:Facility Design and Construction; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D053783:Magnetic Resonance Imaging, Interventional; D018787:Radiation Oncology / Q000295:instrumentation*; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation*