title: Hyperuricemia in hematologic malignancies is caused by an insufficient urinary excretion.
abstract: In order to elucidate the mechanism of hyperuricemia in hematologic malignancies, we have retrospectively investigated the uric acid metabolism in 418 chemotherapy-naïve patients with hematologic malignancies. Hyperuricemia was present in 116 (27.8%) of these patients on initial hospitalization. Among 65 hyperuricemic patients analyzed uric acid metabolism, six (9.2%) had overproduction type, 52 (80.0%) had underexcretion type, and seven (10.8%) had a mixed type. Fourteen patients (3.3%) developed tumor lysis syndrome in 418 patients.
authors.affiliation: a Department of Internal Medicine , Teikyo University, School of Medicine , Kaga Itabashiku , Tokyo , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Oka
authors.forename: Haruko
authors.initials: H
authors.lastname: Tashiro
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Sirasaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Nobu
authors.initials: N
authors.lastname: Akiyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawasugi
authors.forename: Naoki
authors.initials: N
authors.lastname: Shirafuji
authors.forename: Shin
authors.initials: S
authors.lastname: Fujimori
mesh_terms: D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000473:pathology; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000503:physiopathology / Q000652:urine*; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D047368:Tumor Burden; D015275:Tumor Lysis Syndrome / Q000150:complications; D014527:Uric Acid / Q000378:metabolism / Q000652:urine
chemical_list: D014527:Uric Acid
keywords: Hematologic malignancies; tumor lysis syndrome; uric acid