title: A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice.
abstract: BACKGROUND
  Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization.
  
  
  METHODS
  Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP.
  
  
  RESULTS
  Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression.
  
  
  CONCLUSIONS
  Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.
authors.forename: Chiou-Yueh
authors.initials: CY
authors.lastname: Yeh
authors.forename: Chiau-Jing
authors.initials: CJ
authors.lastname: Jung
authors.forename: Ching-Ning
authors.initials: CN
authors.lastname: Huang
authors.forename: Ying-Che
authors.initials: YC
authors.lastname: Huang
authors.forename: Huei-Ting
authors.initials: HT
authors.lastname: Lien
authors.forename: Won-Bo
authors.initials: WB
authors.lastname: Wang
authors.affiliation: Graduate Institute of Immunology, College of Medicine, National Taiwan University, No, 1, Jen Ai Road 1st Section, Taipei City 10051, Taiwan. lifangwa@ntu.edu.tw.
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Wang
authors.forename: Jean-San
authors.initials: JS
authors.lastname: Chia
mesh_terms: D000485:Allergens / Q000276:immunology / Q000378:metabolism; D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D004768:Enterotoxins / Q000276:immunology / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D005285:Fermentation; D007155:Immunologic Factors / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D007378:Interleukins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D012867:Skin / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D000485:Allergens; D004768:Enterotoxins; D007155:Immunologic Factors; D007378:Interleukins; D010936:Plant Extracts; C031818:enterotoxin B, staphylococcal