title: A comparative study on phenolic components and biological activity of some Senecio species in Turkey.
abstract: OBJECTIVE
  The phenolic components and biological activity of nine Senecio species growing in Turkey were investigated.
  
  
  METHODS
  Senecio species were extracted with methanol. The content of total phenols was determined using Folin-Ciocalteu method, while individual phenolic acids and flavonoids were detected using HPLC analysis. Also, to determine the antioxidant capacity, phosphomolybdenum assay and 1,1-diphenyl picrylhydrazyl (DPPH) radical-scavenging activity assay were used. Antimicrobial activity of extract was determined using agar diffusion and broth microdilution method.
  
  
  RESULTS
  The total phenolic contents of the extracts were found to be highest in Senecio cilicius and Senecio mollis extracts (117.45 and 113.40 mg equivalent to gallic acid/g, respectively). S. salsuginea showed the strongest free radical-scavenging activity with IC50 (the concentration providing 50% inhibition) = 26.23 μg/ml and S. mollis showed the highest antioxidant capacity in the phosphomolybdenum method (434.48 mg equivalent to ascorbic acid/g). The extracts exerted promising antibacterial activity against most of the test bacteria (minimal inhibitory concentration = 6.25-12.5 mg/ml), but no activity was observed against Candida albicans.
  
  
  CONCLUSIONS
  The results demonstrated that nine Senecio species possess high antioxidant and antimicrobial activity in accordance with the high amount of phenolic contents in the extracts that might be natural agencies used in many areas such as food, pharmacy and alternative medicine.
authors.affiliation: Science Faculty, Department of Biology, Erciyes University, Kayseri, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Albayrak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aksoy
authors.forename: Lutfiye
authors.initials: L
authors.lastname: Yurtseven
authors.forename: Abit
authors.initials: A
authors.lastname: Yaşar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology*; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism; D018515:Plant Leaves; D012674:Senecio / Q000737:chemistry*; D014421:Turkey
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D010636:Phenols; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Senecio; antimicrobial activity; antioxidant activity; phenolic