title: [Role of genes and their cis-regulatory elements during animal morphological evolution].
abstract: Cis-regulatory hypothesis is one of the most important theories in evolutionary developmental biology (evo-devo), which claims that evolution of cis-regulatory elements (CREs) plays a key role during evolution of morphology. However, an increasing number of experimental results show that cis-regulatory hypothesis alone is not far enough to explain the complexity of evo-devo processes. Other modifications, including mutations of protein coding, gene and genome duplications, and flexibility of homeodomains and CREs, also cause the morphological changes in animals. In this review, we retrospect the recent results of evolution of CREs and genes associated with CREs and discuss new methods and trends for research in evo-devo.
authors.affiliation: Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Boyuan
authors.initials: B
authors.lastname: Sun
authors.affiliation: Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Tu
authors.affiliation: Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China.
authors.forename: Mingyao
authors.initials: M
authors.lastname: Yang
mesh_terms: D000818:Animals; D005075:Biological Evolution; D056890:Eukaryota / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009024:Morphogenesis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D011506:Proteins