title: Comparison of salivary IgA secretion rate collected by the aspiration method and swab method.
abstract: Salivary immunoglobulin A (IgA) is used as an immunity marker, as saliva can be easily collected, noninvasively with little stress. However, several saliva collection methods can be used. Our comparison between samples collected using different methods demonstrated that the salivary IgA secretion rate in samples collected using an aspiration method was significantly correlated with that in samples collected using a swab method. Moreover, the significant circadian variation in salivary IgA secretion rate in the aspirated saliva suggested that the aspiration method does not suppress salivary IgA secretion rate variability compared with the swab method. Therefore, the aspiration method should be considered as the preferable saliva collection method.
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., 3-31-13 Saigawa Otsu, Shiga 520-0002, Japan ; Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., 3-31-13 Saigawa Otsu, Shiga 520-0002, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hamuro
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., 3-31-13 Saigawa Otsu, Shiga 520-0002, Japan ; Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., 3-31-13 Saigawa Otsu, Shiga 520-0002, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kotani
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., 3-31-13 Saigawa Otsu, Shiga 520-0002, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Toba
authors.affiliation: Information Management Office, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kakumoto
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., 3-31-13 Saigawa Otsu, Shiga 520-0002, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kohda
keywords: IgA; Saliva collection; aspiration; swab