title: Current understanding of HIV-1 and T-cell adaptive immunity: progress to date.
abstract: The cellular immune response to human immunodeficiency virus (HIV) has different components originating from both the adaptive and innate immune systems. HIV cleverly utilizes the host machinery to survive by its intricate nature of interaction with the host immune system. HIV evades the host immune system at innate ad adaptive, allows the pathogen to replicate and transmit from one host to another. Researchers have shown that HIV has multipronged effects especially on the adaptive immunity, with CD4(+) cells being the worst effect T-cell populations. Various analyses have revealed that, the exposure to HIV results in clonal expansion and excessive activation of the immune system. Also, an abnormal process of differentiation has been observed suggestive of an alteration and blocks in the maturation of various T-cell subsets. Additionally, HIV has shown to accelerate immunosenescence and exhaustion of the overtly activated T-cells. Apart from causing phenotypic changes, HIV has adverse effects on the functional aspect of the immune system, with evidences implicating it in the loss of the capacity of T-cells to secrete various antiviral cytokines and chemokines. However, there continues to be many aspects of the immune- pathogenesis of HIV that are still unknown and thus required further research in order to convert the malaise of HIV into a manageable epidemic.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences (A.I.I.M.S.), Ansari Nagar, New Delhi 110029, India. Electronic address: mohan.teena@gmail.com.
authors.forename: Teena
authors.initials: T
authors.lastname: Mohan
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences (A.I.I.M.S.), Ansari Nagar, New Delhi 110029, India.
authors.forename: Santwana
authors.initials: S
authors.lastname: Bhatnagar
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences (A.I.I.M.S.), Ansari Nagar, New Delhi 110029, India.
authors.forename: Dablu L
authors.initials: DL
authors.lastname: Gupta
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences (A.I.I.M.S.), Ansari Nagar, New Delhi 110029, India. Electronic address: dnrao311@rediffmail.com.
authors.forename: D N
authors.initials: DN
authors.lastname: Rao
mesh_terms: D056704:Adaptive Immunity; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D013601:T-Lymphocytes / Q000276:immunology*
keywords: CD4(+)/CD8(+) T-cells; Differentiation; Immune activation; Immune exhaustion; Proliferation