title: MUC5B promoter polymorphisms and risk of coal workers' pneumoconiosis in a Chinese population.
abstract: Coal workers' pneumoconiosis (CWP) is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Genetic variations have been recognized to be involved in the multi-factorial susceptibility to CWP, and MUC5B is a candidate lung fibrosis susceptibility gene. In the present study, we investigated possible genetic associations between three single nucleotide polymorphisms in MUC5B promoter region and CWP in a case-control study including 686 CWP patients and 680 controls. Genotyping was carried out by TaqMan method. Only rs2672794 allele and genotype frequencies distributions were significantly different between CWP patients and controls (P = 0.017 and 0.046 for allele and genotype, respectively). The MUC5B rs2672794 CC genotype was associated with a significantly increased risk of CWP, compared with the TT genotype. Moreover, individuals with TC/CC genotype had an obviously increased risk of CWP than those with TT genotype, particularly among subgroups of dust exposure <27 years and smokers. This is the first report showing an association between the MUC5B rs2672794 polymorphism and CWP, and our results suggest that MUC5B rs2672794 CC genotype could increase the risk of CWP. Further studies are warranted to confirm our findings.
authors.affiliation: Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Ji
authors.forename: Baiqun
authors.initials: B
authors.lastname: Wu
authors.forename: Kexin
authors.initials: K
authors.lastname: Jin
authors.forename: Chen
authors.initials: C
authors.lastname: Luo
authors.forename: Ruhui
authors.initials: R
authors.lastname: Han
authors.forename: Minjuan
authors.initials: M
authors.lastname: Chen
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Hou
authors.forename: Jingjing
authors.initials: J
authors.lastname: Fan
authors.forename: Chunhui
authors.initials: C
authors.lastname: Ni
mesh_terms: D000368:Aged; D000483:Alleles; D055008:Anthracosis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003032:Coal Mining; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D055257:Mucin-5B / Q000235:genetics*; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D012907:Smoking
chemical_list: C524578:MUC5B protein, human; D055257:Mucin-5B