title: Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer.
abstract: Androgens were at one time a therapeutic mainstay in the treatment of advanced breast cancer. Despite comparable efficacy, SERMs and aromatase inhibitors eventually became the therapies of choice due to in part to preferred side-effect profiles. Molecular characterization of breast tumors has revealed an abundance of androgen receptor expression but the choice of an appropriate androgen receptor ligand (agonist or antagonist) has been confounded by multiple conflicting reports concerning the role of the receptor in the disease. Modern clinical efforts have almost exclusively utilized antagonists. However, the recent clinical development of selective androgen receptor modulators with greatly improved side-effect profiles has renewed interest in androgen agonist therapy for advanced breast cancer.
authors.affiliation: GTx, Inc., Memphis, TN 38103, United States.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Coss
authors.affiliation: GTx, Inc., Memphis, TN 38103, United States.
authors.forename: Amanda
authors.initials: A
authors.lastname: Jones
authors.affiliation: GTx, Inc., Memphis, TN 38103, United States. Electronic address: jdalton@gtxinc.com.
authors.forename: James T
authors.initials: JT
authors.lastname: Dalton
mesh_terms: D000728:Androgens / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
chemical_list: D000728:Androgens; D020845:Selective Estrogen Receptor Modulators
keywords: Androgen; Breast; Cancer; Nonsteroidal; Receptor