title: Anisometropia in children with neurofibromatosis type 1 and unilateral optic nerve glioma.
abstract: BACKGROUND
  Optic nerve glioma (ONG) occurs in 5% to 25% of individuals with neurofibromatosis type 1 (NF1). Recently an association between this lesion and unilateral myopia was reported in a series of 4 pediatric patients. The purpose of this study was to determine whether unilateral ONG is associated with an increased prevalence of anisometropia.
  
  
  METHODS
  The medical records of children <16 years of age with NF1 disease and unilateral ONG or normal neuroimaging examined at Tel-Aviv Medical Center between April 2008 and July 2013 were retrospectively reviewed to determine the prevalence of anisometropia and anisoastigmatism.
  
  
  RESULTS
  A total of 75 children with NF1 disease were included. Of these, 25 (11 boys) had a unilateral ONG (mean age, 7.2 years; range, 2-16 years) and 50 (29 boys) had normal neuroimaging (mean age, 8.3 years; range, 1-15 years). The mean refraction (spherical equivalent) of eyes with ONG did not differ significantly from that of the contralateral eyes (0.74 ± 1.41 D vs 0.71 ± 1.19 D; P = 0.935; 95% CI, -0.710 to 0.770); moreover, there was a high correlation between the refraction of eyes with ONG and contralateral eyes (r = 0.946, P < 0.001). The prevalence of anisometropia in children with ONG and in NF1 children with no orbital pathology did not differ significantly (8% vs 16%; P = 0.480), and the prevalence of anisoastigmatism was also similar in both groups (4% vs 14%, P = 0.255).
  
  
  CONCLUSIONS
  ONG in children with NF1 is not associated with increased prevalence of anisometropia.
authors.affiliation: Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Maccabi Healthcare Services, Ramat Hsharon, Israel. Electronic address: gaddotan@hotmail.com.
authors.forename: Gad
authors.initials: G
authors.lastname: Dotan
authors.affiliation: Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shay
authors.initials: S
authors.lastname: Keren
authors.affiliation: Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Chaim
authors.initials: C
authors.lastname: Stolovitch
authors.affiliation: Gilbert Israeli Neurofibromatosis Center, Pediatric Neurology and Child development Center Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Hagit
authors.initials: H
authors.lastname: Toledano-Alhadef
authors.affiliation: Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Kesler
mesh_terms: D000293:Adolescent; D015858:Anisometropia / Q000150:complications* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D020339:Optic Nerve Glioma / Q000150:complications*; D015995:Prevalence; D012189:Retrospective Studies