title: Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents.
abstract: Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 µM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 µM) when compared to galantamine (IC50 = 211.8 ± 9.5 µM).
authors.affiliation: DCTD, University of Azores, Rua Mãe de Deus, Ponta Delgada 9501-801, Portugal.
authors.forename: Ana M L
authors.initials: AM
authors.lastname: Seca
authors.affiliation: Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago, Aveiro 3810-193, Portugal.
authors.forename: Stephanie B
authors.initials: SB
authors.lastname: Leal
authors.affiliation: Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago, Aveiro 3810-193, Portugal. diana@ua.pt.
authors.forename: Diana C G A
authors.initials: DC
authors.lastname: Pinto
authors.affiliation: DCTD, University of Azores, Rua Mãe de Deus, Ponta Delgada 9501-801, Portugal.
authors.forename: Maria Carmo
authors.initials: MC
authors.lastname: Barreto
authors.affiliation: Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago, Aveiro 3810-193, Portugal. artur.silva@ua.pt.
authors.forename: Artur M S
authors.initials: AM
authors.lastname: Silva
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005290:Ferric Compounds