title: Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.
abstract: IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.
authors.affiliation: Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Tedder
authors.affiliation: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 208921674, USA.
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Leonard
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology* / Q000628:therapy; D015551:Autoimmunity; D060151:B-Lymphocytes, Regulatory / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D000098546:Interleukin-21
chemical_list: D015415:Biomarkers; D007378:Interleukins; C532417:interleukin-35, human; D016753:Interleukin-10; D000098546:Interleukin-21