title: The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil.
abstract: OBJECTIVE
  To evaluate the association of the PTPN2 rs1893217 polymorphism with T1DM and/or its clinical and laboratory characteristics in a Caucasian population from Southern Brazil.
  
  
  METHODS
  Four hundred and eighty six patients with T1DM and 484 non-diabetic subjects were included in the study. Genotyping of the PTPN2 rs1893217 was performed by real-time PCR.
  
  
  RESULTS
  Genotype frequencies did not differ between T1DM patients and non-diabetic subjects (P = 0.265). The C allele was observed in 14.5% of the T1DM sample and 12.2% of the non-diabetic group (P = 0.152). Moreover, the frequencies of this variant did not differ statistically between T1DM patients and non-diabetic subjects when assuming recessive, dominant, or additive inheritance models. The clinical and laboratory characteristics of T1DM patients did not differ significantly among the three genotypes of the rs1893217 polymorphism, either.
  
  
  CONCLUSIONS
  The PTPN2 rs1893217 polymorphism is not significantly associated with T1DM in Caucasian subjects from Southern Brazil.
authors.affiliation: Laboratory of Biology of Human Pancreatic Islets, Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Jakeline
authors.initials: J
authors.lastname: Rheinheimer
authors.affiliation: Laboratory of Biology of Human Pancreatic Islets, Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Fernanda dos Santos de
authors.initials: Fdos S
authors.lastname: Oliveira
authors.affiliation: Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Luís Henrique
authors.initials: LH
authors.lastname: Canani
authors.affiliation: Laboratory of Biology of Human Pancreatic Islets, Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Daisy
authors.initials: D
authors.lastname: Crispim
mesh_terms: D000328:Adult; D000419:Albuminuria; D000483:Alleles; D000704:Analysis of Variance; D001938:Brazil; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D014280:Triglycerides / Q000097:blood; D044465:White People / Q000235:genetics*
chemical_list: D002784:Cholesterol; D008076:Cholesterol, HDL; D003404:Creatinine; D006442:Glycated Hemoglobin; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2; D014280:Triglycerides; C516649:PTPN2 protein, human