title: [Malignant peripheral nerve sheath tumour of the infra-orbital nerve].
abstract: A malignant peripheral nerve sheath tumour (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. It is even more infrequent for these tumours to affect cranial nerves. We report the case of a 53-year-old man who presented a MPNST involving the infra-orbital nerve, which extended through the orbit and the base of the skull, progressing intracranially. Histological studies identified the tumour as an MPNST. Response to radiotherapy was not complete and radical surgical resection was impossible, so the patient died 10months later. This rare case of MPNST with intracranial involvement illustrates the dismal prognosis for patients with these lesions. Prognosis is poor because of the difficulty of performing radical surgery with free margins in these locations.
authors.affiliation: Servicio de Otorrinolaringología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: ricardomorujo@hotmail.com.
authors.forename: Ricardo
authors.initials: R
authors.lastname: González-Orús Álvarez-Morujo
authors.affiliation: Servicio de Neurocirugía, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: Roberto
authors.initials: R
authors.lastname: García Leal
authors.affiliation: Servicio de Cirugía Plástica y Reparadora, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Lasso Vázquez
authors.affiliation: Servicio de Otorrinolaringología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: Barolomé
authors.initials: B
authors.lastname: Scola Yurrita
mesh_terms: D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008297:Male; D008442:Maxillary Nerve; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis / Q000601:surgery
keywords: Cranial nerve; Infraorbital nerve; Malignant peripheral nerve sheath tumour; Malignant schwannoma; Nervio craneal; Nervio infraorbitario; Neurosarcoma; Schwannoma maligno; Tumor maligno de vaina de nervio periférico