title: Of worms and men: HLH-30 and TFEB regulate tolerance to infection.
abstract: In this issue of Immunity, Visvikis et al. (2014) use the model host Caenorhabditis elegans to discover a role in innate immunity for the basic helix-loop-helix transcription factor, HLH-30. The finding inspires study of the mammalian ortholog TFEB, in which a similar role in immune response is ascertained.
authors.affiliation: University of Texas Health Science Center, Houston Department of Microbiology and Molecular Genetics, 6431 Fannin Street, MSB 1.168, Houston, TX 77030, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Tiller
authors.affiliation: University of Texas Health Science Center, Houston Department of Microbiology and Molecular Genetics, 6431 Fannin Street, MSB 1.168, Houston, TX 77030, USA. Electronic address: danielle.a.garsin@uth.tmc.edu.
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Garsin
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000276:immunology*; D051792:Basic Helix-Loop-Helix Proteins / Q000276:immunology*; D017173:Caenorhabditis elegans / Q000276:immunology* / Q000382:microbiology*; D029742:Caenorhabditis elegans Proteins / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D029742:Caenorhabditis elegans Proteins; C583069:HLH-30 protein, C elegans; C484068:Tcfeb protein, mouse