title: Does hyoscine butylbromide really improve polyp detection during colonoscopy? A meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To investigate the benefits of hyoscine butylbromide in polyp detection during colonoscopy by a meta-analysis of available randomized controlled trials (RCTs).
  
  
  METHODS
  Databases, including PubMed, EMBASE, the Cochrane Library, and the Science Citation Index up to September 2013, were searched. The primary outcome was polyp detection rate, and the secondary outcome was adenoma detection rate. The meta-analysis was performed using the free software Review Manager. Differences observed between the treated and the control groups were expressed as odds ratio (OR) with a 95% confidence interval (CI). A fixed-effects model was used to pool data when statistical heterogeneity was absent. If statistical heterogeneity was present (P < 0.05), a random-effects model was used.
  
  
  RESULTS
  The initial search identified nine articles. After screening, five RCTs with a total of 1998 patients were included in this meta-analysis. Of the five studies, all described a comparison of baseline patient characteristics and showed that there was no statistically significant difference between the two groups. Among the 1998 patients, 1006 received hyoscine butylbromide and 992 were allocated to the control group, and the polyp detection rate was reported. There were no signiﬁcant differences between the treated and the control group (OR = 1.09, 95%CI: 0.91-1.31, P = 0.33). Four RCTs included 1882 patients, of whom 948 received hyoscine butylbromide, and the adenoma detection rate was reported. There were no signiﬁcant differences between the treated and the control group (OR = 1.13, 95%CI: 0.92-1.38, P = 0.24).
  
  
  CONCLUSIONS
  The use of hyoscine butylbromide did not significantly improve the polyp detection rate during colonoscopy.
authors.affiliation: Pei-Jing Cui, Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Pei-Jing
authors.initials: PJ
authors.lastname: Cui
authors.affiliation: Pei-Jing Cui, Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yao
authors.affiliation: Pei-Jing Cui, Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Hua-Zhong
authors.initials: HZ
authors.lastname: Han
authors.affiliation: Pei-Jing Cui, Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Pei-Jing Cui, Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D002086:Butylscopolammonium Bromide; D016009:Chi-Square Distribution; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003111:Colonic Polyps / Q000175:diagnosis* / Q000473:pathology; D003113:Colonoscopy / Q000379:methods*; D006801:Humans; D016017:Odds Ratio; D010276:Parasympatholytics; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic
chemical_list: D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide
keywords: Adenoma detection; Colonoscopy; Hyoscine butylbromide; Polyp detection