title: Systems biology of synaptic plasticity: a review on N-methyl-D-aspartate receptor mediated biochemical pathways and related mathematical models.
abstract: Synaptic plasticity, an emergent property of synaptic networks, has shown strong correlation to one of the essential functions of the brain, memory formation. Through understanding synaptic plasticity, we hope to discover the modulators and mechanisms that trigger memory formation. In this paper, we first review the well understood modulators and mechanisms underlying N-methyl-D-aspartate receptor dependent synaptic plasticity, a major form of synaptic plasticity in hippocampus, and then comment on the key mathematical modelling approaches available in the literature to understand synaptic plasticity as the integration of the established functionalities of synaptic components.
authors.affiliation: Centre for Advanced Computational Solutions (C-fACS), Molecular Biosciences Department, Lincoln University, Christchurch, New Zealand.
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.affiliation: Centre for Advanced Computational Solutions (C-fACS), Molecular Biosciences Department, Lincoln University, Christchurch, New Zealand. Electronic address: don.kulasiri@lincoln.ac.nz.
authors.forename: D
authors.initials: D
authors.lastname: Kulasiri
authors.affiliation: Centre for Advanced Computational Solutions (C-fACS), Molecular Biosciences Department, Lincoln University, Christchurch, New Zealand.
authors.forename: S
authors.initials: S
authors.lastname: Samarasinghe
mesh_terms: D001921:Brain / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D006801:Humans; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*; D017470:Receptors, Glutamate / Q000235:genetics / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology / Q000379:methods* / Q000639:trends
chemical_list: D002147:Calmodulin; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C492973:alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, human; D002118:Calcium
keywords: LTD; LTP; Memory formation; Synaptic plasticity; Systems biology